MCID: DCN001
MIFTS: 27

Dic in Newborn

Categories: Blood diseases

Aliases & Classifications for Dic in Newborn

MalaCards integrated aliases for Dic in Newborn:

Name: Dic in Newborn 12 15
Disseminated Intravascular Coagulation in Newborn 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11246
ICD9CM 34 776.2
NCIt 50 C111856
SNOMED-CT 67 34417008
ICD10 32 P60
UMLS 70 C0158992

Summaries for Dic in Newborn

MalaCards based summary : Dic in Newborn, also known as disseminated intravascular coagulation in newborn, is related to disseminated intravascular coagulation and platelet aggregation, spontaneous. An important gene associated with Dic in Newborn is SERPINF2 (Serpin Family F Member 2), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. Affiliated tissues include heart, spinal cord and liver, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Dic in Newborn

Diseases related to Dic in Newborn via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 197)
# Related Disease Score Top Affiliating Genes
1 disseminated intravascular coagulation 28.2 SERPINF2 SERPINE1 SERPINC1 F7 F3 F2
2 platelet aggregation, spontaneous 10.2 SERPINF2 SERPINC1
3 cold urticaria 10.2 SERPINF2 SERPINC1
4 spinal cord infarction 10.1 SERPINC1 F2
5 lateral sinus thrombosis 10.1 SERPINC1 F2
6 respiratory distress syndrome in premature infants 10.1
7 newborn respiratory distress syndrome 10.1
8 thoracic outlet syndrome 10.1 SERPINC1 F2
9 abducens nerve disease 10.1 SERPINC1 F2
10 prothrombin deficiency, congenital 10.1 SERPINC1 F2
11 mastoiditis 10.1 SERPINC1 F2
12 anterior cerebral artery infarction 10.1 SERPINC1 F2
13 central retinal artery occlusion 10.1 SERPINC1 F2
14 plasminogen activator inhibitor-1 deficiency 10.1 SERPINF2 SERPINE1
15 fibrinolytic defect 10.1 SERPINE1 SERPINC1
16 sneddon syndrome 10.1 SERPINC1 F2
17 sticky platelet syndrome 10.1 SERPINE1 SERPINC1
18 dysfibrinogenemia, congenital 10.1 SERPINC1 F2
19 antithrombin iii deficiency 10.1 SERPINC1 F2
20 hypersplenism 10.1 SERPINC1 F2
21 meningococcemia 10.1 SERPINE1 SERPINC1
22 argentine hemorrhagic fever 10.1 SERPINE1 SERPINC1
23 placental abruption 10.0 SERPINC1 F2
24 legg-calve-perthes disease 10.0 SERPINE1 SERPINC1
25 vertical talus, congenital 10.0 SERPINC1 F2
26 cryptogenic cirrhosis 10.0 SERPINE1 F2
27 korean hemorrhagic fever 10.0 SERPINF2 F3
28 malignant secondary hypertension 10.0 SERPINE1 F7
29 heparin-induced thrombocytopenia 10.0 SERPINC1 F3
30 vulvar angiokeratoma 10.0 SERPINC1 F3
31 nonarteritic anterior ischemic optic neuropathy 10.0 SERPINC1 F2
32 leech infestation 10.0 SERPINC1 F3
33 coronary heart disease 1 9.9 SERPINE1 F7
34 vulvar benign neoplasm 9.9 SERPINC1 F3
35 chronic venous insufficiency 9.9 SERPINE1 F2
36 venous insufficiency 9.9 SERPINE1 F2
37 achenbach syndrome 9.9 F3 F2
38 renal pelvis squamous cell carcinoma 9.9 F3 F2
39 papillary adenofibroma 9.9 F3 F2
40 femoral neuropathy 9.9 F3 F2
41 emphysematous cholecystitis 9.9 F3 F2
42 hemopneumothorax 9.9 F3 F2
43 cerebral falx meningioma 9.9 F3 F2
44 ankylosing spondylitis 1 9.9 F3 F2
45 acute pulmonary heart disease 9.9 F3 F2
46 epidural abscess 9.9 F3 F2
47 lemierre's syndrome 9.9 F3 F2
48 acute cor pulmonale 9.9 F3 F2
49 posterior cerebral artery infarction 9.9 F3 F2
50 gastric hemangioma 9.9 F3 F2

Graphical network of the top 20 diseases related to Dic in Newborn:



Diseases related to Dic in Newborn

Symptoms & Phenotypes for Dic in Newborn

MGI Mouse Phenotypes related to Dic in Newborn:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.43 ANXA2 F2 F3 F7 SERPINC1 SERPINE1
2 homeostasis/metabolism MP:0005376 9.17 ANXA2 F2 F3 F7 SERPINC1 SERPINE1

Drugs & Therapeutics for Dic in Newborn

Search Clinical Trials , NIH Clinical Center for Dic in Newborn

Genetic Tests for Dic in Newborn

Anatomical Context for Dic in Newborn

MalaCards organs/tissues related to Dic in Newborn:

40
Heart, Spinal Cord, Liver, Placenta, Pituitary

Publications for Dic in Newborn

Articles related to Dic in Newborn:

# Title Authors PMID Year
1
Diagnosis of DIC in very low birth weight infants. 61
9834015 1998
2
[New approach to the diagnosis of disseminated intravascular coagulation in childhood]. 61
8433530 1993
3
[Disseminated intravascular coagulation in newborn infants with infection]. 61
2762053 1989
4
[Results of treatment of disseminated intravascular coagulation in newborn infants with septicemia]. 61
6634257 1983
5
Diagnosis of DIC in newborn infants. 61
6421273 1983
6
Therapy for DIC in newborn infants. 61
6667253 1983
7
Disseminated intravascular coagulation in newborn infants. Prevalence in autopsies and significance as a cause of death. 61
7134058 1982
8
[Disseminated intravascular coagulation in newborn and other infants]. 61
5066386 1972

Variations for Dic in Newborn

Expression for Dic in Newborn

Search GEO for disease gene expression data for Dic in Newborn.

Pathways for Dic in Newborn

GO Terms for Dic in Newborn

Cellular components related to Dic in Newborn according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 SERPINF2 SERPINE1 SERPINC1 F2 ANXA2
2 extracellular region GO:0005576 9.7 SERPINF2 SERPINE1 SERPINC1 F7 F3 F2
3 endoplasmic reticulum lumen GO:0005788 9.54 SERPINC1 F7 F2
4 blood microparticle GO:0072562 9.5 SERPINF2 SERPINC1 F2
5 extracellular space GO:0005615 9.5 SERPINF2 SERPINE1 SERPINC1 F7 F3 F2
6 platelet alpha granule lumen GO:0031093 9.43 SERPINF2 SERPINE1
7 serine-type peptidase complex GO:1905286 9.26 F7 F3
8 collagen-containing extracellular matrix GO:0062023 9.17 SERPINF2 SERPINE1 SERPINC1 F7 F3 F2

Biological processes related to Dic in Newborn according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of peptidase activity GO:0010466 9.67 SERPINF2 SERPINE1 SERPINC1
2 blood coagulation GO:0007596 9.67 SERPINC1 F7 F3 F2
3 negative regulation of endopeptidase activity GO:0010951 9.62 SERPINF2 SERPINE1 SERPINC1 ANXA2
4 positive regulation of interleukin-8 production GO:0032757 9.57 SERPINE1 F3
5 collagen fibril organization GO:0030199 9.56 SERPINF2 ANXA2
6 acute-phase response GO:0006953 9.55 SERPINF2 F2
7 positive regulation of collagen biosynthetic process GO:0032967 9.54 SERPINF2 F2
8 regulation of blood coagulation GO:0030193 9.52 SERPINC1 F2
9 positive regulation of positive chemotaxis GO:0050927 9.51 F7 F3
10 response to thyroid hormone GO:0097066 9.48 F7 ANXA2
11 negative regulation of plasminogen activation GO:0010757 9.46 SERPINF2 SERPINE1
12 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.43 F7 F3
13 positive regulation of blood coagulation GO:0030194 9.43 SERPINE1 F7 F2
14 blood coagulation, extrinsic pathway GO:0007598 9.4 F7 F3
15 negative regulation of fibrinolysis GO:0051918 9.33 SERPINF2 SERPINE1 F2
16 hemostasis GO:0007599 9.26 SERPINC1 F7 F3 F2
17 fibrinolysis GO:0042730 8.92 SERPINF2 SERPINE1 F2 ANXA2

Molecular functions related to Dic in Newborn according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.5 SERPINE1 F7 F2
2 serine-type endopeptidase activity GO:0004252 9.43 F7 F3 F2
3 peptidase inhibitor activity GO:0030414 9.33 SERPINF2 SERPINE1 SERPINC1
4 serine-type endopeptidase inhibitor activity GO:0004867 9.26 SERPINF2 SERPINE1 SERPINC1 ANXA2
5 protease binding GO:0002020 9.02 SERPINF2 SERPINE1 SERPINC1 F3 ANXA2

Sources for Dic in Newborn

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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