MCID: DCR010
MIFTS: 30

Dicer1 Tumor Predisposition

Categories: Cancer diseases, Endocrine diseases, Genetic diseases, Nephrological diseases

Aliases & Classifications for Dicer1 Tumor Predisposition

MalaCards integrated aliases for Dicer1 Tumor Predisposition:

Name: Dicer1 Tumor Predisposition 25
Dicer1 Syndrome 25 43 6 17
Dicer1 Pleuropulmonary Blastoma Familial Tumor Predisposition Syndrome 25
Dicer1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome 43
Pleuropulmonary Blastoma Familial Tumor and Dysplasia Syndrome 43
Pleuropulmonary Blastoma Family Tumor Susceptibility Syndrome 43

Characteristics:

GeneReviews:

25
Penetrance The penetrance of heterozygous germline dicer1 pathogenic variants is reduced and age dependent. in a longitudinal natural history study of 145 individuals with a germline dicer1 pathogenic variant and 135 family controls, the cumulative incidence of mng or thyroidectomy by age 40 years was 75% in women and 17% in men versus 8% and 0% in control women and men [khan et al 2017b]....

Classifications:



External Ids:

Summaries for Dicer1 Tumor Predisposition

MedlinePlus Genetics : 43 DICER1 syndrome is an inherited disorder that increases the risk of a variety of cancerous and noncancerous (benign) tumors, most commonly certain types of tumors that occur in the lungs, kidneys, ovaries, and thyroid (a butterfly-shaped gland in the lower neck). Affected individuals can develop one or more types of tumors, and members of the same family can have different types. However, the risk of tumor formation in individuals with DICER1 syndrome is only moderately increased compared with tumor risk in the general population; most individuals with genetic changes associated with this condition never develop tumors.People with DICER1 syndrome who develop tumors most commonly develop pleuropulmonary blastoma, which is characterized by tumors that grow in lung tissue or in the outer covering of the lungs (the pleura). These tumors occur in infants and young children and are rare in adults. Pleuropulmonary blastoma is classified as one of three types on the basis of tumor characteristics: in type I, the growths are composed of air-filled pockets called cysts; in type II, the growths contain both cysts and solid tumors (or nodules); and in type III, the growth is a solid tumor that can fill a large portion of the chest. Pleuropulmonary blastoma is considered cancerous, and types II and III can spread (metastasize), often to the brain, liver, or bones. Individuals with pleuropulmonary blastoma may also develop an abnormal accumulation of air in the chest cavity that can lead to the collapse of a lung (pneumothorax).Cystic nephroma, which involves multiple benign fluid-filled cysts in the kidneys, can also occur; in people with DICER1 syndrome, the cysts develop early in childhood.DICER1 syndrome is also associated with tumors in the ovaries known as Sertoli-Leydig cell tumors, which typically develop in affected women in their teens or twenties. Some Sertoli-Leydig cell tumors release the male sex hormone testosterone; in these cases, affected women may develop facial hair, a deep voice, and other male characteristics. Some affected women have irregular menstrual cycles. Sertoli-Leydig cell tumors usually do not metastasize.People with DICER1 syndrome are also at risk of multinodular goiter, which is enlargement of the thyroid gland caused by the growth of multiple fluid-filled or solid tumors (both referred to as nodules). The nodules are generally slow-growing and benign. Despite the growths, the thyroid's function is often normal. Rarely, individuals with DICER1 syndrome develop thyroid cancer (thyroid carcinoma).

MalaCards based summary : Dicer1 Tumor Predisposition, also known as dicer1 syndrome, is related to dicer1-related pleuropulmonary blastoma cancer predisposition syndrome and tumor predisposition syndrome. An important gene associated with Dicer1 Tumor Predisposition is DICER1 (Dicer 1, Ribonuclease III). Affiliated tissues include thyroid, lung and pituitary.

GeneReviews: NBK196157

Related Diseases for Dicer1 Tumor Predisposition

Diseases related to Dicer1 Tumor Predisposition via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 dicer1-related pleuropulmonary blastoma cancer predisposition syndrome 11.6
2 tumor predisposition syndrome 10.4
3 differentiated thyroid carcinoma 10.1
4 rare tumor 10.1
5 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.0
6 pleuropulmonary blastoma 10.0
7 multinodular goiter 10.0
8 nephroma 10.0
9 goiter 10.0
10 pineoblastoma 10.0
11 leydig cell tumor 10.0
12 sertoli-leydig cell tumor 10.0
13 embryonal rhabdomyosarcoma 10.0
14 rhabdomyosarcoma 10.0
15 embryoma 10.0
16 medulloepithelioma 10.0
17 gynandroblastoma 10.0
18 thyroid carcinoma 10.0
19 sarcoma 10.0
20 spindle cell sarcoma 10.0
21 neuroblastoma 10.0
22 overgrowth syndrome 10.0
23 basal cell nevus syndrome 9.8
24 pilomatrixoma 9.8
25 medulloblastoma 9.8
26 cystic disease of lung 9.8
27 lymphoma, hodgkin, classic 9.8
28 papilloma of choroid plexus 9.8
29 retinitis pigmentosa 9.8
30 rhabdomyosarcoma, embryonal, 1 9.8
31 alacrima, achalasia, and mental retardation syndrome 9.8
32 global developmental delay, lung cysts, overgrowth, and wilms tumor 9.8
33 familial adenomatous polyposis 9.8
34 lymphoma 9.8
35 ovarian sex-cord stromal tumor 9.8
36 neuroretinitis 9.8
37 nephrocalcinosis 9.8
38 squamous cell papilloma 9.8
39 amenorrhea 9.8
40 thyroid gland cancer 9.8
41 basal cell carcinoma 9.8
42 papilloma 9.8
43 fibrosarcoma 9.8
44 atypical choroid plexus papilloma 9.8
45 retinitis 9.8
46 kidney sarcoma 9.8
47 ovarian cyst 9.8
48 nephrolithiasis 9.8
49 adenoma 9.8
50 47,xyy 9.8

Graphical network of the top 20 diseases related to Dicer1 Tumor Predisposition:



Diseases related to Dicer1 Tumor Predisposition

Symptoms & Phenotypes for Dicer1 Tumor Predisposition

Drugs & Therapeutics for Dicer1 Tumor Predisposition

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 DICER1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study Recruiting NCT01247597

Search NIH Clinical Center for Dicer1 Tumor Predisposition

Genetic Tests for Dicer1 Tumor Predisposition

Anatomical Context for Dicer1 Tumor Predisposition

MalaCards organs/tissues related to Dicer1 Tumor Predisposition:

40
Thyroid, Lung, Pituitary, Cervix, Eye, Ovary, Fetal Lung

Publications for Dicer1 Tumor Predisposition

Articles related to Dicer1 Tumor Predisposition:

(show top 50) (show all 170)
# Title Authors PMID Year
1
Poorly differentiated thyroid carcinoma of childhood and adolescence: a distinct entity characterized by DICER1 mutations. 25 61
31937902 2020
2
An update on the central nervous system manifestations of DICER1 syndrome. 61 25
30953130 2020
3
Mesenchymal Hamartoma of the Liver and DICER1 Syndrome. 61 25
31390509 2019
4
Mesenchymal Hamartoma of the Liver and DICER1 Syndrome. 61 25
31067372 2019
5
Neoplasm Risk Among Individuals With a Pathogenic Germline Variant in DICER1. 61 25
30715996 2019
6
The prevalence of germline DICER1 pathogenic variation in cancer populations. 25 61
30672147 2019
7
DICER1 Syndrome: Characterization of the Ocular Phenotype in a Family-Based Cohort Study. 61 25
30339877 2019
8
Clinical and Molecular Characteristics May Alter Treatment Strategies of Thyroid Malignancies in DICER1 Syndrome. 25 61
30260442 2019
9
Structural renal abnormalities in the DICER1 syndrome: a family-based cohort study. 61 25
30178239 2018
10
[DICER1 mutated, solid/trabecular thyroid papillary carcinoma in an 11-year-old child]. 61 25
29884466 2018
11
Multiple DICER1-related tumors in a child with a large interstitial 14q32 deletion. 61 25
29315962 2018
12
Anaplastic sarcomas of the kidney are characterized by DICER1 mutations. 61 25
28862265 2018
13
The prevalence of DICER1 pathogenic variation in population databases. 61 25
28748527 2017
14
Quantification of Thyroid Cancer and Multinodular Goiter Risk in the DICER1 Syndrome: A Family-Based Cohort Study. 25 61
28323992 2017
15
Macrocephaly associated with the DICER1 syndrome. 61 25
27441995 2017
16
DICER1 Mutations and Differentiated Thyroid Carcinoma: Evidence of a Direct Association. 25 61
26555935 2016
17
High-sensitivity sequencing reveals multi-organ somatic mosaicism causing DICER1 syndrome. 25 61
26475046 2016
18
Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in pleuropulmonary blastoma / DICER1 syndrome: a unique variant of the two-hit tumor suppression model. 61 25
26925222 2015
19
Pituitary blastoma: a pathognomonic feature of germ-line DICER1 mutations. 61 25
24839956 2014
20
Exploring the association Between DICER1 mutations and differentiated thyroid carcinoma. 25 61
24617712 2014
21
DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome. 61 25
21266384 2011
22
DICER1-associated central nervous system sarcoma in children: comprehensive clinicopathologic and genetic analysis of a newly described rare tumor. 25
32291395 2020
23
Hotspot Mutations in DICER1 Causing GLOW Syndrome-Associated Macrocephaly via Modulation of Specific microRNA Populations Result in the Activation of PI3K/ATK/mTOR Signaling. 25
31232238 2020
24
Presacral malignant teratoid neoplasm in association with pathogenic DICER1 variation. 25
31296931 2019
25
Dental abnormalities in individuals with pathogenic germline variation in DICER1. 25
31313479 2019
26
Germline DICER1-mutant intracranial sarcoma with dual chondroid and spindle cell morphology and pulmonary metastases treated with multimodal therapy. 25
30989777 2019
27
Intraocular medulloepithelioma - A review of clinical features, DICER 1 mutation, and management. 25
31124483 2019
28
Successful treatment of metastatic cerebral recurrence of pleuropulmonary blastoma. 25
30677214 2019
29
DICER1 mutations are frequent in müllerian adenosarcomas and are independent of rhabdomyosarcomatous differentiation. 25
30266945 2019
30
Plaque Radiotherapy for Medulloepithelioma in 6 Cases From a Single Center. 25
30375203 2019
31
ETMR-like infantile cerebellar embryonal tumors in the extended morphologic spectrum of DICER1-related tumors. 25
30446821 2019
32
Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations. 25
29881993 2018
33
DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies. 25
29343557 2018
34
DICER1 Mutations Are Frequent in Adolescent-Onset Papillary Thyroid Carcinoma. 25
29474644 2018
35
A rare malignant thyroid carcinosarcoma with aggressive behavior and DICER1 gene mutation: a case report with literature review. 25
30083234 2018
36
DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry. 25
29037807 2017
37
The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies. 25
28349240 2017
38
Evaluation of age-dependent treatment strategies for children and young adults with pineoblastoma: analysis of pooled European Society for Paediatric Oncology (SIOP-E) and US Head Start data. 25
28011926 2017
39
Mixed Epithelial and Stromal Tumor of the Kidney: Mutation Analysis of the DICER 1 Gene in 29 Cases. 25
26509905 2017
40
Timing, rates and spectra of human germline mutation. 25
26656846 2016
41
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer. 25
25900731 2015
42
Nasal Chondromesenchymal Hamartoma (NCMH): a systematic review of the literature with a new case report. 25
26138824 2015
43
Pleuropulmonary blastoma: a report on 350 central pathology-confirmed pleuropulmonary blastoma cases by the International Pleuropulmonary Blastoma Registry. 25
25209242 2015
44
Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA hairpin loop sequences. 25
24909177 2014
45
DICER1 mutations in childhood cystic nephroma and its relationship to DICER1-renal sarcoma. 25
24481001 2014
46
Expanding the phenotype of mutations in DICER1: mosaic missense mutations in the RNase IIIb domain of DICER1 cause GLOW syndrome. 25
24676357 2014
47
Germ-line deletion in DICER1 revealed by a novel MLPA assay using synthetic oligonucleotides. 25
24065110 2014
48
Germ-line and somatic DICER1 mutations in a pleuropulmonary blastoma. 25
23868280 2013
49
Ciliary body medulloepithelioma: analysis of 41 cases. 25
23796765 2013
50
Ciliary body medulloepithelioma associated with pleuropulmonary blastoma. 25
23613510 2013

Variations for Dicer1 Tumor Predisposition

ClinVar genetic disease variations for Dicer1 Tumor Predisposition:

6 (show top 50) (show all 2118)
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 DICER1 NM_177438.2(DICER1):c.489C>G (p.Tyr163Ter) SNV Pathogenic 220675 rs864622626 14:95596479-95596479 14:95130142-95130142
2 DICER1 NM_177438.2(DICER1):c.2236A>G (p.Arg746Gly) SNV Pathogenic 254305 rs886037686 14:95577674-95577674 14:95111337-95111337
3 DICER1 NM_177438.2(DICER1):c.832C>T (p.Leu278Phe) SNV Pathogenic 254354 rs768248216 14:95592988-95592988 14:95126651-95126651
4 DICER1 NM_177438.2(DICER1):c.2437-2A>G SNV Pathogenic 412146 rs1060503640 14:95574432-95574432 14:95108095-95108095
5 DICER1 NM_030621.4(DICER1):c.1706_1710del (p.Ile569fs) Deletion Pathogenic 412198 rs1060503665 14:95582832-95582836 14:95116495-95116499
6 DICER1 NM_030621.4(DICER1):c.4130del (p.Pro1377fs) Deletion Pathogenic 412050 rs34678453 14:95566193-95566193 14:95099856-95099856
7 DICER1 NM_030621.4(DICER1):c.1747del (p.Glu583fs) Deletion Pathogenic 412131 rs1060503633 14:95582795-95582795 14:95116458-95116458
8 DICER1 NM_030621.4(DICER1):c.1767del (p.Lys589fs) Deletion Pathogenic 412191 rs1060503662 14:95582144-95582144 14:95115807-95115807
9 DICER1 NM_030621.4(DICER1):c.2953del (p.Gln985fs) Deletion Pathogenic 412122 rs1060503627 14:95572412-95572412 14:95106075-95106075
10 DICER1 NM_177438.2(DICER1):c.3349G>T (p.Glu1117Ter) SNV Pathogenic 412104 rs1060503617 14:95570384-95570384 14:95104047-95104047
11 DICER1 NM_177438.2(DICER1):c.5494C>T (p.Gln1832Ter) SNV Pathogenic 412037 rs1060503583 14:95557573-95557573 14:95091236-95091236
12 DICER1 NM_030621.4(DICER1):c.2507_2508del (p.Phe836fs) Deletion Pathogenic 412123 rs1060503628 14:95574359-95574360 14:95108022-95108023
13 DICER1 NM_030621.4(DICER1):c.459dup (p.Val154fs) Duplication Pathogenic 477209 rs1555375978 14:95596508-95596509 14:95130171-95130172
14 DICER1 NM_177438.2(DICER1):c.901C>T (p.Gln301Ter) SNV Pathogenic 477292 rs781144010 14:95592919-95592919 14:95126582-95126582
15 DICER1 NM_030621.4(DICER1):c.1137del (p.Lys379fs) Deletion Pathogenic 477023 rs1555374734 14:95590772-95590772 14:95124435-95124435
16 DICER1 NM_001195573.1(DICER1):c.5365-142del Deletion Pathogenic 477261 rs1555366197 14:95557588-95557588 14:95091251-95091251
17 DICER1 NM_030621.4(DICER1):c.256del (p.Arg86fs) Deletion Pathogenic 477107 rs1555376375 14:95598903-95598903 14:95132566-95132566
18 DICER1 NM_177438.2(DICER1):c.823G>T (p.Glu275Ter) SNV Pathogenic 477290 rs1555375333 14:95592997-95592997 14:95126660-95126660
19 DICER1 NM_177438.2(DICER1):c.4638C>A (p.Tyr1546Ter) SNV Pathogenic 477210 rs773822569 14:95562619-95562619 14:95096282-95096282
20 DICER1 NM_030621.4(DICER1):c.1694del (p.Asp565fs) Deletion Pathogenic 477053 rs1555372851 14:95582848-95582848 14:95116511-95116511
21 DICER1 NM_030621.4(DICER1):c.1417del (p.Tyr473fs) Deletion Pathogenic 477039 rs1555373228 14:95584051-95584051 14:95117714-95117714
22 DICER1 NM_177438.2(DICER1):c.1029dup (p.Phe344fs) Duplication Pathogenic 477022 rs1555374772 14:95590879-95590880 14:95124542-95124543
23 DICER1 NM_030621.4(DICER1):c.535del (p.Ala180fs) Deletion Pathogenic 477257 rs1555375946 14:95596433-95596433 14:95130096-95130096
24 DICER1 NM_030621.4(DICER1):c.2197_2198GA[3] (p.Thr734fs) Microsatellite Pathogenic 477091 rs1555371596 14:95577709-95577710 14:95111372-95111373
25 DICER1 NM_030621.4(DICER1):c.282_283dup (p.Arg95fs) Duplication Pathogenic 477120 rs1555376368 14:95598875-95598876 14:95132538-95132539
26 DICER1 NM_030621.4(DICER1):c.757dup (p.Ile253fs) Duplication Pathogenic 543554 rs1555375356 14:95593062-95593063 14:95126725-95126726
27 DICER1 NM_177438.2(DICER1):c.100C>T (p.Gln34Ter) SNV Pathogenic 543565 rs1555376548 14:95599696-95599696 14:95133359-95133359
28 DICER1 NM_177438.3(DICER1):c.4401_4402CT[2] (p.Leu1469fs) Microsatellite Pathogenic 422631 rs1064795904 14:95562851-95562852 14:95096514-95096515
29 DICER1 NM_030621.4(DICER1):c.4212del (p.Asp1405fs) Deletion Pathogenic 543615 rs1555367927 14:95563045-95563045 14:95096708-95096708
30 DICER1 NM_030621.4(DICER1):c.2955delinsTT (p.Gln985fs) Indel Pathogenic 543648 rs1555370268 14:95572410-95572410 14:95106073-95106073
31 DICER1 NM_030621.4(DICER1):c.2370_2373dup (p.Leu792fs) Duplication Pathogenic 543649 rs1555370915 14:95574723-95574724 14:95108386-95108387
32 DICER1 NM_030621.4(DICER1):c.947G>A (p.Trp316Ter) SNV Pathogenic 543605 rs1555374839 14:95590962-95590962 14:95124625-95124625
33 DICER1 NM_030621.4(DICER1):c.4762del (p.Gly1587_Leu1588insTer) Deletion Pathogenic 570976 rs1566754840 14:95562495-95562495 14:95096158-95096158
34 DICER1 NM_177438.2(DICER1):c.1376+1G>A SNV Pathogenic 573393 rs886037670 14:95590532-95590532 14:95124195-95124195
35 DICER1 NM_177438.2(DICER1):c.2988-1G>T SNV Pathogenic 429116 rs1131691192 14:95572121-95572121 14:95105784-95105784
36 DICER1 NM_177438.2(DICER1):c.3688C>T (p.Gln1230Ter) SNV Pathogenic 576876 rs1566767799 14:95570045-95570045 14:95103708-95103708
37 DICER1 NM_177438.2(DICER1):c.4031C>G (p.Ser1344Ter) SNV Pathogenic 582884 rs1566766572 14:95569702-95569702 14:95103365-95103365
38 DICER1 NM_177438.2(DICER1):c.1501C>T (p.Gln501Ter) SNV Pathogenic 643405 rs1595414962 14:95583967-95583967 14:95117630-95117630
39 DICER1 NM_030621.4(DICER1):c.3957dup (p.Asp1320fs) Duplication Pathogenic 575211 rs1566766788 14:95569775-95569776 14:95103438-95103439
40 DICER1 NM_177438.2(DICER1):c.5103C>G (p.Tyr1701Ter) SNV Pathogenic 523888 rs875989780 14:95560486-95560486 14:95094149-95094149
41 DICER1 NM_177438.2(DICER1):c.1847T>A (p.Leu616Ter) SNV Pathogenic 574836 rs771634025 14:95582064-95582064 14:95115727-95115727
42 DICER1 NM_177438.2(DICER1):c.3591C>A (p.Cys1197Ter) SNV Pathogenic 576410 rs1566768212 14:95570142-95570142 14:95103805-95103805
43 DICER1 NM_030621.4(DICER1):c.238G>T (p.Glu80Ter) SNV Pathogenic 649946 rs1595466234 14:95598921-95598921 14:95132584-95132584
44 DICER1 NM_030621.4(DICER1):c.3909_3910del (p.Ser1304fs) Deletion Pathogenic 652078 rs1595364159 14:95569823-95569824 14:95103486-95103487
45 DICER1 NM_030621.4(DICER1):c.5261_5364+79del Deletion Pathogenic 580813 rs1566749829 14:95560146-95560328 14:95093809-95093991
46 DICER1 NC_000014.9:g.(?_95090488)_(95133468_?)del Deletion Pathogenic 655753 14:95556825-95599805 14:95090488-95133468
47 DICER1 NM_030621.4(DICER1):c.4458dup (p.Ser1487fs) Duplication Pathogenic 429122 rs1131691197 14:95562798-95562799 14:95096461-95096462
48 DICER1 NM_177438.2(DICER1):c.2988-20_2988del Deletion Pathogenic 660444 rs1595372924 14:95572120-95572140 14:95105783-95105803
49 DICER1 NM_030621.4(DICER1):c.3402del (p.Gln1135fs) Deletion Pathogenic 663671 rs1595367266 14:95570331-95570331 14:95103994-95103994
50 DICER1 NM_030621.4(DICER1):c.1280_1283del (p.Lys427fs) Deletion Pathogenic 658250 rs1595438347 14:95590626-95590629 14:95124289-95124292

Cosmic variations for Dicer1 Tumor Predisposition:

9 (show top 50) (show all 492)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM87996646 TP53 lung,NS,carcinoma,blastoma c.454C>A p.P152T 17:7675158-7675158 3
2 COSM144141681 TP53 lung,NS,carcinoma,blastoma c.-26C>T p.? 17:7675160-7675160 3
3 COSM143944155 TP53 lung,NS,carcinoma,blastoma c.367C>T p.R123W 17:7673776-7673776 3
4 COSM87898723 TP53 lung,NS,carcinoma,blastoma c.817C>T p.R273C 17:7673803-7673803 3
5 COSM112336073 TP53 lung,NS,carcinoma,blastoma c.454C>A p.P152T 17:7675158-7675158 3
6 COSM112319842 TP53 lung,NS,carcinoma,blastoma c.452C>T p.P151L 17:7675160-7675160 3
7 COSM122278092 TP53 lung,NS,carcinoma,blastoma c.121G>T p.V41L 17:7675095-7675095 3
8 COSM143215096 TP53 lung,NS,carcinoma,blastoma c.-26C>T p.? 17:7675160-7675160 3
9 COSM144013682 TP53 lung,NS,carcinoma,blastoma c.811C>T p.R271W 17:7673776-7673776 3
10 COSM143946931 TP53 lung,NS,carcinoma,blastoma c.58C>G p.H20D 17:7675077-7675077 3
11 COSM122347785 TP53 lung,NS,carcinoma,blastoma c.58C>A p.P20T 17:7675158-7675158 3
12 COSM122271827 TP53 lung,NS,carcinoma,blastoma c.448C>T p.R150W 17:7673776-7673776 3
13 COSM111827058 TP53 lung,NS,carcinoma,blastoma c.452C>T p.P151L 17:7675160-7675160 3
14 COSM106134013 TP53 lung,NS,carcinoma,blastoma c.454C>A p.P152T 17:7675158-7675158 3
15 COSM144658526 TP53 lung,NS,carcinoma,blastoma c.400G>T p.V134L 17:7675095-7675095 3
16 COSM121876472 TP53 lung,NS,carcinoma,blastoma c.448C>T p.R150W 17:7673776-7673776 3
17 COSM111758883 TP53 lung,NS,carcinoma,blastoma c.817C>T p.R273C 17:7673803-7673803 3
18 COSM142852638 TP53 lung,NS,carcinoma,blastoma c.713G>T p.C238F 17:7674250-7674250 3
19 COSM144156961 TP53 lung,NS,carcinoma,blastoma c.-24C>A p.? 17:7675158-7675158 3
20 COSM106072690 TP53 lung,NS,carcinoma,blastoma c.713G>T p.C238F 17:7674250-7674250 3
21 COSM143159516 TP53 lung,NS,carcinoma,blastoma c.58C>G p.H20D 17:7675077-7675077 3
22 COSM144016688 TP53 lung,NS,carcinoma,blastoma c.502C>G p.H168D 17:7675077-7675077 3
23 COSM122734401 TP53 lung,NS,carcinoma,blastoma c.448C>T p.R150W 17:7673776-7673776 3
24 COSM143449537 TP53 lung,NS,carcinoma,blastoma c.337C>A p.P113T 17:7675158-7675158 3
25 COSM142566746 TP53 lung,NS,carcinoma,blastoma c.400G>T p.V134L 17:7675095-7675095 3
26 COSM144672287 TP53 lung,NS,carcinoma,blastoma c.596G>T p.C199F 17:7674250-7674250 3
27 COSM145024750 TP53 lung,NS,carcinoma,blastoma c.400G>T p.V134L 17:7675095-7675095 3
28 COSM112256417 TP53 lung,NS,carcinoma,blastoma c.535C>G p.H179D 17:7675077-7675077 3
29 COSM121884280 TP53 lung,NS,carcinoma,blastoma c.121G>T p.V41L 17:7675095-7675095 3
30 COSM112253888 TP53 lung,NS,carcinoma,blastoma c.844C>T p.R282W 17:7673776-7673776 3
31 COSM142560558 TP53 lung,NS,carcinoma,blastoma c.727C>T p.R243W 17:7673776-7673776 3
32 COSM105627506 TP53 lung,NS,carcinoma,blastoma c.517G>T p.V173L 17:7675095-7675095 3
33 COSM122290992 TP53 lung,NS,carcinoma,blastoma c.317G>T p.C106F 17:7674250-7674250 3
34 COSM144364665 TP53 lung,NS,carcinoma,blastoma c.335C>T p.P112L 17:7675160-7675160 3
35 COSM106117301 TP53 lung,NS,carcinoma,blastoma c.452C>T p.P151L 17:7675160-7675160 3
36 COSM143371151 TP53 lung,NS,carcinoma,blastoma c.727C>T p.R243W 17:7673776-7673776 3
37 COSM142907856 TP53 lung,NS,carcinoma,blastoma c.454C>A p.P152T 17:7675158-7675158 3
38 COSM144310437 TP53 lung,NS,carcinoma,blastoma c.727C>T p.R243W 17:7673776-7673776 3
39 COSM105623950 TP53 lung,NS,carcinoma,blastoma c.535C>G p.H179D 17:7675077-7675077 3
40 COSM93190437 TP53 lung,NS,carcinoma,blastoma c.517G>T p.V173L 17:7675095-7675095 3
41 COSM143374265 TP53 lung,NS,carcinoma,blastoma c.418C>G p.H140D 17:7675077-7675077 3
42 COSM143162405 TP53 lung,NS,carcinoma,blastoma c.40G>T p.V14L 17:7675095-7675095 3
43 COSM143949547 TP53 lung,NS,carcinoma,blastoma c.40G>T p.V14L 17:7675095-7675095 3
44 COSM143371158 TP53 lung,NS,carcinoma,blastoma c.700C>T p.R234C 17:7673803-7673803 3
45 COSM111762163 TP53 lung,NS,carcinoma,blastoma c.535C>G p.H179D 17:7675077-7675077 3
46 COSM143433713 TP53 lung,NS,carcinoma,blastoma c.335C>T p.P112L 17:7675160-7675160 3
47 COSM112253896 TP53 lung,NS,carcinoma,blastoma c.817C>T p.R273C 17:7673803-7673803 3
48 COSM93184004 TP53 lung,NS,carcinoma,blastoma c.844C>T p.R282W 17:7673776-7673776 3
49 COSM143157023 TP53 lung,NS,carcinoma,blastoma c.367C>T p.R123W 17:7673776-7673776 3
50 COSM87922049 TP53 lung,NS,carcinoma,blastoma c.713G>T p.C238F 17:7674250-7674250 3

Expression for Dicer1 Tumor Predisposition

Search GEO for disease gene expression data for Dicer1 Tumor Predisposition.

Pathways for Dicer1 Tumor Predisposition

GO Terms for Dicer1 Tumor Predisposition

Sources for Dicer1 Tumor Predisposition

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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