MCID: DCL001
MIFTS: 25

Diclofenac Allergy

Categories: Immune diseases

Aliases & Classifications for Diclofenac Allergy

MalaCards integrated aliases for Diclofenac Allergy:

Name: Diclofenac Allergy 12 15
Voltaren Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040031
SNOMED-CT 67 293613006
UMLS 70 C0570540

Summaries for Diclofenac Allergy

Disease Ontology : 12 A drug allergy that has allergic trigger diclofenac.

MalaCards based summary : Diclofenac Allergy, also known as voltaren allergy, is related to chlorhexidine allergy and crab allergy. An important gene associated with Diclofenac Allergy is CD63 (CD63 Molecule), and among its related pathways/superpathways are NF-kappaB Signaling and Kit receptor signaling pathway. Affiliated tissues include bone, bone marrow and heart, and related phenotype is digestive/alimentary.

Related Diseases for Diclofenac Allergy

Diseases related to Diclofenac Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 chlorhexidine allergy 10.3 ENPP3 CD63
2 crab allergy 10.3 ENPP3 CD63
3 apricot allergy 10.3 PTGDR2 ENPP3
4 chronic inducible urticaria 10.3 ENPP3 CD63
5 dermatographia 10.3 ENPP3 CD63
6 nut allergy 10.3 ENPP3 CD63
7 physical urticaria 10.3 ENPP3 CD63
8 cefaclor allergy 10.2 CD63 ALB
9 vagus nerve disease 10.2 ATP4A ATP12A
10 necrotizing gastritis 10.2 ATP4A ATP12A
11 scalp dermatosis 10.2 ATP4A ATP12A
12 hemangioma of intra-abdominal structure 10.2 ATP4A ATP12A
13 acquired gastric outlet stenosis 10.2 ATP4A ATP12A
14 lingual goiter 10.2 ATP4A ATP12A
15 displacement of cardia through esophageal hiatus 10.2 ATP4A ATP12A
16 bacterial esophagitis 10.2 ATP4A ATP12A
17 cascade stomach 10.2 ATP4A ATP12A
18 benzylpenicillin allergy 10.2 ATP4A ATP12A
19 median arcuate ligament syndrome 10.2 ATP4A ATP12A
20 legume allergy 10.2 ENPP3 CD63
21 cervix erosion 10.2 ATP4A ATP12A
22 angiodysplasia of intestine 10.2 ATP4A ATP12A
23 angiodysplasia 10.2 ATP4A ATP12A
24 granulomatous gastritis 10.2 ATP4A ATP12A
25 laryngeal tuberculosis 10.2 ATP4A ATP12A
26 fruit allergy 10.2 ENPP3 CD63
27 fungal esophagitis 10.2 ATP4A ATP12A
28 dieulafoy lesion 10.2 ATP4A ATP12A
29 esophagus melanoma 10.2 ATP4A ATP12A
30 cefuroxime allergy 10.2 ATP4A ATP12A
31 emphysematous cholecystitis 10.2 ATP4A ATP12A
32 gastric gastrinoma 10.2 ATP4A ATP12A
33 superior mesenteric artery syndrome 10.2 ATP4A ATP12A
34 pneumatosis cystoides intestinalis 10.2 ATP4A ATP12A
35 chronic laryngitis 10.2 ATP4A ATP12A
36 laryngitis 10.2 ATP4A ATP12A
37 viral laryngitis 10.2 ATP4A ATP12A
38 gastroduodenal crohn's disease 10.2 ATP4A ATP12A
39 central nervous system origin vertigo 10.2 ATP4A ATP12A
40 rumination disorder 10.2 ATP4A ATP12A
41 internal hemorrhoid 10.2 ATP4A ATP12A
42 acute laryngitis 10.2 ATP4A ATP12A
43 gastroduodenitis 10.2 ATP4A ATP12A
44 barbiturate abuse 10.2 ATP4A ATP12A
45 duodenal gastrinoma 10.2 ATP4A ATP12A
46 gastric dilatation 10.2 ATP4A ATP12A
47 gastric hemangioma 10.2 ATP4A ATP12A
48 polycystic echinococcosis 10.2 ATP4A ATP12A
49 lymphocytic gastritis 10.2 ATP4A ATP12A
50 x-linked chondrodysplasia punctata 1 10.2 ATP4A ATP12A

Graphical network of the top 20 diseases related to Diclofenac Allergy:



Diseases related to Diclofenac Allergy

Symptoms & Phenotypes for Diclofenac Allergy

MGI Mouse Phenotypes related to Diclofenac Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.1 ALB ATP12A ATP4A CD63 ENPP3 PTPRC

Drugs & Therapeutics for Diclofenac Allergy

Search Clinical Trials , NIH Clinical Center for Diclofenac Allergy

Genetic Tests for Diclofenac Allergy

Anatomical Context for Diclofenac Allergy

MalaCards organs/tissues related to Diclofenac Allergy:

40
Bone, Bone Marrow, Heart, Skin, Cervix, Myeloid

Publications for Diclofenac Allergy

Articles related to Diclofenac Allergy:

# Title Authors PMID Year
1
Anaphylaxis to diclofenac: nine cases reported to the Allergy Vigilance Network in France. 61
24931488 2014
2
Suppression of gastric acid increases the risk of developing immunoglobulin E-mediated drug hypersensitivity: human diclofenac sensitization and a murine sensitization model. 61
19817752 2010
3
Diclofenac induces basophil degranulation without increasing CD63 expression in sensitive patients. 61
17177968 2007

Variations for Diclofenac Allergy

Expression for Diclofenac Allergy

Search GEO for disease gene expression data for Diclofenac Allergy.

Pathways for Diclofenac Allergy

Pathways related to Diclofenac Allergy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.97 PTPRC IL3 ENPP3 CD63
2
Show member pathways
11.46 IL3RA IL3 ENPP3 CCR3
3
Show member pathways
11.28 IL3RA IL3
4 11.09 PTPRC PTGDR2 IL3RA IL3 CCR3

GO Terms for Diclofenac Allergy

Cellular components related to Diclofenac Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.86 PTPRC PTGDR2 IL3RA ENPP3 CD63 CCR3
2 plasma membrane GO:0005886 9.56 PTPRC PTGDR2 IL3RA ENPP3 CD63 CCR3
3 integral component of plasma membrane GO:0005887 9.55 PTPRC PTGDR2 CD63 CCR3 ATP4A
4 external side of plasma membrane GO:0009897 8.92 PTPRC IL3RA ENPP3 CCR3

Biological processes related to Diclofenac Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.32 ATP4A ATP12A
2 cellular sodium ion homeostasis GO:0006883 9.26 ATP4A ATP12A
3 sodium ion export across plasma membrane GO:0036376 9.16 ATP4A ATP12A
4 cellular potassium ion homeostasis GO:0030007 8.96 ATP4A ATP12A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP4A ATP12A

Molecular functions related to Diclofenac Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Diclofenac Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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