MCID: DNC009
MIFTS: 23

Diencephalic Astrocytoma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Diencephalic Astrocytoma

MalaCards integrated aliases for Diencephalic Astrocytoma:

Name: Diencephalic Astrocytoma 12 15
Astrocytoma of Diencephalon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4855
NCIt 50 C5128
UMLS 70 C1333284

Summaries for Diencephalic Astrocytoma

MalaCards based summary : Diencephalic Astrocytoma, also known as astrocytoma of diencephalon, is related to isolated growth hormone deficiency type iii and partial third-nerve palsy. An important gene associated with Diencephalic Astrocytoma is GHRL (Ghrelin And Obestatin Prepropeptide), and among its related pathways/superpathways are Peptide hormone metabolism and Tight junction.

Related Diseases for Diencephalic Astrocytoma

Diseases related to Diencephalic Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 isolated growth hormone deficiency type iii 10.3 GH2 GH1
2 partial third-nerve palsy 10.3 SALL4 GH1
3 central precocious puberty 10.2 LEP GH1
4 predominantly cortical thymoma 10.2 CD1E CD1A
5 tolosa-hunt syndrome 10.2 CD1E CD1A
6 dendritic cell thymoma 10.2 CD1E CD1A
7 postgastrectomy syndrome 10.2 INS GHRL
8 multifocal motor neuropathy 10.2 CD1E CD1A
9 oral hairy leukoplakia 10.2 CD1E CD1A
10 pityriasis rosea 10.1 CD1E CD1A
11 kimura disease 10.1 CD1E CD1A
12 hypothalamic obesity 10.1 LEP INS
13 marasmus 10.1 INS GH1
14 short bowel syndrome 10.1 LEP GHRL GH1
15 hypothalamic disease 10.1 INS GH1
16 nutritional deficiency disease 10.1 LEP GHRL GH1
17 eating disorder 10.1 LEP GHRL GH1
18 pica disease 10.1 LEP INS
19 juvenile xanthogranuloma 10.1 CD1E CD1A
20 pituitary apoplexy 10.1 INS GH1
21 mite infestation 10.1 CD1B CD1A
22 functional gastric disease 10.1 INS GHRL
23 fetal macrosomia 10.1 LEP INS
24 alzheimer disease 9 10.1 INS GHRL
25 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.1 LEP INS
26 empty sella syndrome 10.1 INS GH1
27 complete generalized lipodystrophy 10.1 LEP INS
28 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 10.1 LEP INS
29 skin sarcoidosis 10.1 CD1C CD1B
30 skin tag 10.1 LEP INS
31 dumping syndrome 10.1 INS GHRL
32 protein-deficiency anemia 10.0 INS GH2 GH1
33 hyperpituitarism 10.0 INS GH2 GH1
34 pituitary gland disease 10.0 INS GH2 GH1
35 craniopharyngioma 10.0 INS GHRL GH1
36 apnea, obstructive sleep 10.0 LEP INS GHRL
37 anovulation 10.0 LEP INS GHRL
38 bulimia nervosa 10.0 LEP INS GHRL
39 amenorrhea 10.0 LEP INS GHRL
40 persistent fetal circulation syndrome 10.0 LEP INS GH2
41 ovarian primitive germ cell tumor 10.0 SALL4 POU5F1
42 ovarian endodermal sinus tumor 10.0 SALL4 POU5F1
43 sleep apnea 10.0 LEP INS GHRL
44 sleep disorder 10.0 LEP INS GHRL
45 abdominal obesity-metabolic syndrome 1 10.0 LEP INS GHRL
46 acanthosis nigricans 10.0 LEP INS GH1
47 central nervous system germ cell tumor 10.0 SALL4 POU5F1
48 intratubular embryonal carcinoma 10.0 TCF4 POU5F1
49 insulin-like growth factor i 10.0 LEP INS GH1
50 uremia 10.0 LEP INS GH1

Graphical network of the top 20 diseases related to Diencephalic Astrocytoma:



Diseases related to Diencephalic Astrocytoma

Symptoms & Phenotypes for Diencephalic Astrocytoma

Drugs & Therapeutics for Diencephalic Astrocytoma

Search Clinical Trials , NIH Clinical Center for Diencephalic Astrocytoma

Genetic Tests for Diencephalic Astrocytoma

Anatomical Context for Diencephalic Astrocytoma

Publications for Diencephalic Astrocytoma

Articles related to Diencephalic Astrocytoma:

# Title Authors PMID Year
1
The role of leptin in diencephalic syndrome. 61
24366994 2014
2
Spontaneous involution of a diencephalic astrocytoma. 61
9838268 1998
3
[Diagnosis and follow-up of Russel's diencephalic cachexia by echography, x-ray computed tomography and nuclear magnetic resonance]. 61
3330195 1987

Variations for Diencephalic Astrocytoma

Expression for Diencephalic Astrocytoma

Search GEO for disease gene expression data for Diencephalic Astrocytoma.

Pathways for Diencephalic Astrocytoma

GO Terms for Diencephalic Astrocytoma

Cellular components related to Diencephalic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 9.72 CD1E CD1D CD1C CD1B CD1A
2 lysosome GO:0005764 9.67 CD1E CD1D CD1C CD1B
3 endosome membrane GO:0010008 9.56 CD1D CD1C CD1B CD1A
4 external side of plasma membrane GO:0009897 9.55 CD1E CD1D CD1C CD1B CD1A
5 extracellular space GO:0005615 9.32 LEP INS GHRL GH2 GH1 CD1E
6 endosome lumen GO:0031904 9.13 INS GH2 GH1

Biological processes related to Diencephalic Astrocytoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.95 CD1E CD1D CD1C CD1B CD1A
2 adaptive immune response GO:0002250 9.88 CD1E CD1C CD1B CD1A
3 immune response GO:0006955 9.8 CD1E CD1D CD1C CD1B CD1A
4 regulation of immune response GO:0050776 9.73 CD1D CD1C CD1B CD1A
5 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.69 LEP INS GH1
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 LEP GH2 GH1
7 glucose metabolic process GO:0006006 9.63 LEP INS GHRL
8 response to nutrient levels GO:0031667 9.62 LEP GHRL GH2 GH1
9 positive regulation of multicellular organism growth GO:0040018 9.58 GHRL GH1
10 positive regulation of insulin receptor signaling pathway GO:0046628 9.57 LEP INS
11 animal organ development GO:0048513 9.56 GH2 GH1
12 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1E CD1D CD1C CD1B CD1A
13 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.54 GH2 GH1
14 positive regulation of JAK-STAT cascade GO:0046427 9.54 LEP GH2 GH1
15 growth hormone receptor signaling pathway GO:0060396 9.52 GH2 GH1
16 adult feeding behavior GO:0008343 9.49 LEP GHRL
17 positive regulation of growth GO:0045927 9.43 GHRL GH2 GH1
18 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1E CD1D CD1C CD1B CD1A
19 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Diencephalic Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.65 LEP INS GHRL GH2 GH1
2 lipopeptide binding GO:0071723 9.55 CD1E CD1D CD1C CD1B CD1A
3 exogenous lipid antigen binding GO:0030884 9.35 CD1E CD1D CD1C CD1B CD1A
4 growth hormone receptor binding GO:0005131 9.32 GH2 GH1
5 endogenous lipid antigen binding GO:0030883 9.02 CD1E CD1D CD1C CD1B CD1A

Sources for Diencephalic Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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