MCID: DNC002
MIFTS: 26

Diencephalic Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Diencephalic Neoplasm

MalaCards integrated aliases for Diencephalic Neoplasm:

Name: Diencephalic Neoplasm 12 15 70
Malignant Diencephalic Neoplasm 12 70
Malignant Diencephalic Tumor 12
Tumor of Diencephalon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3843
NCIt 50 C5125 C5126
UMLS 70 C1333286 C1334576

Summaries for Diencephalic Neoplasm

MalaCards based summary : Diencephalic Neoplasm, also known as malignant diencephalic neoplasm, is related to adult oligodendroglioma and protein-deficiency anemia. An important gene associated with Diencephalic Neoplasm is TRPC6 (Transient Receptor Potential Cation Channel Subfamily C Member 6), and among its related pathways/superpathways are Peptide hormone metabolism and Tight junction. Affiliated tissues include pituitary, thymus and bone, and related phenotype is behavior/neurological.

Related Diseases for Diencephalic Neoplasm

Diseases related to Diencephalic Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 adult oligodendroglioma 10.4 MYBL1 KIAA1549
2 protein-deficiency anemia 10.3 GH2 GH1
3 syphilitic encephalitis 10.3 TGM1 FLNA
4 childhood oligodendroglioma 10.3 MYBL1 KIAA1549
5 central precocious puberty 10.2 LEP GH1
6 predominantly cortical thymoma 10.2 CD1E CD1A
7 tolosa-hunt syndrome 10.2 CD1E CD1A
8 partial third-nerve palsy 10.2 SALL4 GH1
9 isolated growth hormone deficiency type iii 10.2 GH2 GH1
10 dendritic cell thymoma 10.2 CD1E CD1A
11 adermatoglyphia 10.2 LEP GH2 GH1
12 adenohypophysitis 10.2 POMC GH1
13 lymphocytic hypophysitis 10.2 POMC GH1
14 ovarian primitive germ cell tumor 10.2 SALL4 POU5F1
15 nutritional deficiency disease 10.2 LEP GHRL GH1
16 multifocal motor neuropathy 10.2 CD1E CD1A
17 ovarian endodermal sinus tumor 10.2 SALL4 POU5F1
18 prediabetes syndrome 10.2 LEP GHRL GH1
19 chromophobe adenoma 10.2 POMC GH1
20 syndromic obesity 10.1 POMC LEP
21 oral hairy leukoplakia 10.1 CD1E CD1A
22 intratubular embryonal carcinoma 10.1 TCF4 POU5F1
23 tsh producing pituitary tumor 10.1 POMC GH1
24 hypothyroidism, congenital, nongoitrous, 4 10.1 POMC GH1
25 central nervous system germ cell tumor 10.1 SALL4 POU5F1
26 pituitary-dependent cushing's disease 10.1 POMC GH1
27 pityriasis rosea 10.1 CD1E CD1A
28 skin sarcoidosis 10.1 CD1C CD1B
29 kimura disease 10.1 CD1E CD1A
30 hypothalamic disease 10.1 POMC GH1
31 classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency 10.1 POMC LEP
32 gangliocytoma 10.1 POMC KIAA1549
33 hyperpituitarism 10.1 POMC GH2 GH1
34 sick building syndrome 10.1 POMC LEP
35 short bowel syndrome 10.1 LEP GHRL GH1 FLNA
36 atypical depressive disorder 10.1 POMC LEP
37 pituitary gland disease 10.0 POMC GH2 GH1
38 amenorrhea 10.0 POMC LEP GHRL
39 sleep disorder 10.0 POMC LEP GHRL
40 mixed type thymoma 10.0 CD1E CD1B CD1A
41 abdominal obesity-metabolic syndrome 1 10.0 POMC LEP GHRL
42 encapsulated thymoma 10.0 CD1E CD1B CD1A
43 sphenoid sinusitis 10.0 CD1E CD1B CD1A
44 epithelial malignant thymoma 10.0 CD1E CD1B CD1A
45 necrobiosis lipoidica 10.0 CD1E CD1B CD1A
46 hypothalamic neoplasm 10.0 TRPC6 TGM1 POMC FLNA
47 hypopituitarism 10.0 POMC LEP GH1
48 granulomatous dermatitis 10.0 CD1E CD1C CD1B
49 mite infestation 9.9 CD1B CD1A
50 eating disorder 9.9 POMC LEP GHRL GH1

Graphical network of the top 20 diseases related to Diencephalic Neoplasm:



Diseases related to Diencephalic Neoplasm

Symptoms & Phenotypes for Diencephalic Neoplasm

MGI Mouse Phenotypes related to Diencephalic Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.44 CD1D FLNA GHRL KIAA1549 LEP MYBL1

Drugs & Therapeutics for Diencephalic Neoplasm

Search Clinical Trials , NIH Clinical Center for Diencephalic Neoplasm

Genetic Tests for Diencephalic Neoplasm

Anatomical Context for Diencephalic Neoplasm

MalaCards organs/tissues related to Diencephalic Neoplasm:

40
Pituitary, Thymus, Bone, Skin

Publications for Diencephalic Neoplasm

Articles related to Diencephalic Neoplasm:

# Title Authors PMID Year
1
[Russell syndrome. Report of a case]. 61
7349011 1980

Variations for Diencephalic Neoplasm

Expression for Diencephalic Neoplasm

Search GEO for disease gene expression data for Diencephalic Neoplasm.

Pathways for Diencephalic Neoplasm

GO Terms for Diencephalic Neoplasm

Cellular components related to Diencephalic Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome GO:0005768 9.73 TLR3 CD1E CD1D CD1C CD1B CD1A
2 external side of plasma membrane GO:0009897 9.55 CD1E CD1D CD1C CD1B CD1A
3 endosome membrane GO:0010008 9.43 TLR3 TBK1 CD1D CD1C CD1B CD1A
4 extracellular space GO:0005615 9.36 TLR3 POMC LEP GHRL GH2 GH1
5 endosome lumen GO:0031904 9.32 GH2 GH1

Biological processes related to Diencephalic Neoplasm according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10 TLR3 TCF4 TBK1 SALL4 POU5F1 POMC
2 immune system process GO:0002376 9.91 TLR3 TBK1 CD1E CD1D CD1C CD1B
3 immune response GO:0006955 9.88 TLR3 CD1E CD1D CD1C CD1B CD1A
4 regulation of immune response GO:0050776 9.78 CD1D CD1C CD1B CD1A
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.67 LEP GH2 GH1
6 response to nutrient levels GO:0031667 9.62 LEP GHRL GH2 GH1
7 positive regulation of JAK-STAT cascade GO:0046427 9.61 LEP GH2 GH1
8 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1E CD1D CD1C CD1B CD1A
9 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.54 GH2 GH1
10 growth hormone receptor signaling pathway GO:0060396 9.52 GH2 GH1
11 adult feeding behavior GO:0008343 9.51 LEP GHRL
12 positive regulation of growth GO:0045927 9.43 GHRL GH2 GH1
13 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1E CD1D CD1C CD1B CD1A
14 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Diencephalic Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.65 POMC LEP GHRL GH2 GH1
2 lipopeptide binding GO:0071723 9.55 CD1E CD1D CD1C CD1B CD1A
3 G protein-coupled receptor binding GO:0001664 9.5 POMC GHRL FLNA
4 growth hormone receptor binding GO:0005131 9.37 GH2 GH1
5 exogenous lipid antigen binding GO:0030884 9.35 CD1E CD1D CD1C CD1B CD1A
6 endogenous lipid antigen binding GO:0030883 9.02 CD1E CD1D CD1C CD1B CD1A

Sources for Diencephalic Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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