MCID: DLF001
MIFTS: 31

Dieulafoy Lesion

Categories: Blood diseases, Cardiovascular diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Dieulafoy Lesion

MalaCards integrated aliases for Dieulafoy Lesion:

Name: Dieulafoy Lesion 12 20 15
Dieulafoy Lesion of Stomach and Duodenum 12
Dieulafoy's Vascular Malformation 71
Dieulafoy Lesion of Intestine 12
Exulceratio Simplex Dieulafoy 20
Dieulafoy's Lesion 20
Dieulafoy Disease 20

Classifications:



External Ids:

Disease Ontology 12 DOID:12070
ICD9CM 34 537.84
ICD10 32 K31.82
UMLS 71 C0341217 C1135229

Summaries for Dieulafoy Lesion

GARD : 20 Dieulafoy lesion is an abnormally large artery (a vessel that takes blood from the heart to other areas of the body) in the lining of the gastrointestinal system. It is most common in the stomach but can occur in other locations, including the small and large intestine. Dieulafoy lesions can cause severe and sudden gastrointestinal bleeding. The condition occurs in people of all ages, but is more common in males than in females. Depending upon the site of the bleeding, symptoms may include vomiting up blood (hematemesis); sticky, dark-colored stools (melena); passage of fresh blood in the stool (hematochezia); or coughing up blood (hemoptysis). Some affected individuals may only present with blood pressure problems. Treatment may include endoscopic and/or surgical techniques. Though treatment can be effective, Dieulafoy lesions and the associated blood loss can be fatal, especially if not diagnosed and treated promptly.

MalaCards based summary : Dieulafoy Lesion, also known as dieulafoy lesion of stomach and duodenum, is related to peptic ulcer disease and varicose veins. An important gene associated with Dieulafoy Lesion is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways is Platelet Aggregation Inhibitor Pathway, Pharmacodynamics. Affiliated tissues include colon, small intestine and appendix, and related phenotype is digestive/alimentary.

Related Diseases for Dieulafoy Lesion

Diseases related to Dieulafoy Lesion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 224)
# Related Disease Score Top Affiliating Genes
1 peptic ulcer disease 30.2 ATP4A ATP12A
2 varicose veins 30.2 VWF F2
3 diverticulitis 30.1 ATP4A ATP12A
4 dysentery 30.1 ATP4A ATP12A
5 esophageal varix 30.1 F2 ATP4A ATP12A
6 purpura 29.8 VWF F2
7 portal hypertension 29.8 VWF F2
8 angiodysplasia 29.8 VWF ATP4A ATP12A
9 volvulus of midgut 29.7 F2 ATP4A ATP12A
10 active peptic ulcer disease 29.5 VWF F2 CYGB ATP4A ATP12A
11 heart valve disease 29.4 VWF F2
12 deficiency anemia 29.4 CYGB ATP4A ATP12A
13 vagus nerve disease 10.2 ATP4A ATP12A
14 necrotizing gastritis 10.2 ATP4A ATP12A
15 scalp dermatosis 10.2 ATP4A ATP12A
16 hemangioma of intra-abdominal structure 10.2 ATP4A ATP12A
17 acquired gastric outlet stenosis 10.2 ATP4A ATP12A
18 lingual goiter 10.2 ATP4A ATP12A
19 displacement of cardia through esophageal hiatus 10.2 ATP4A ATP12A
20 bacterial esophagitis 10.2 ATP4A ATP12A
21 cascade stomach 10.2 ATP4A ATP12A
22 benzylpenicillin allergy 10.2 ATP4A ATP12A
23 median arcuate ligament syndrome 10.2 ATP4A ATP12A
24 afferent loop syndrome 10.2 ATP4A ATP12A
25 cervix erosion 10.2 ATP4A ATP12A
26 angiodysplasia of intestine 10.2 ATP4A ATP12A
27 granulomatous gastritis 10.2 ATP4A ATP12A
28 laryngeal tuberculosis 10.2 ATP4A ATP12A
29 fungal esophagitis 10.2 ATP4A ATP12A
30 esophagus melanoma 10.2 ATP4A ATP12A
31 cefuroxime allergy 10.2 ATP4A ATP12A
32 gastric gastrinoma 10.2 ATP4A ATP12A
33 superior mesenteric artery syndrome 10.2 ATP4A ATP12A
34 pneumatosis cystoides intestinalis 10.2 ATP4A ATP12A
35 chronic laryngitis 10.2 ATP4A ATP12A
36 laryngitis 10.2 ATP4A ATP12A
37 peptic ulcer perforation 10.2 ATP4A ATP12A
38 viral laryngitis 10.2 ATP4A ATP12A
39 gastroduodenal crohn's disease 10.2 ATP4A ATP12A
40 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 ATP4A ATP12A
41 rumination disorder 10.2 ATP4A ATP12A
42 acute laryngitis 10.2 ATP4A ATP12A
43 gastroduodenitis 10.2 ATP4A ATP12A
44 duodenitis 10.2 ATP4A ATP12A
45 chronic intestinal vascular insufficiency 10.2 ATP4A ATP12A
46 barbiturate abuse 10.2 ATP4A ATP12A
47 duodenal gastrinoma 10.2 ATP4A ATP12A
48 gastric dilatation 10.2 ATP4A ATP12A
49 blind loop syndrome 10.2 ATP4A ATP12A
50 polycystic echinococcosis 10.2 ATP4A ATP12A

Graphical network of the top 20 diseases related to Dieulafoy Lesion:



Diseases related to Dieulafoy Lesion

Symptoms & Phenotypes for Dieulafoy Lesion

MGI Mouse Phenotypes related to Dieulafoy Lesion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 ATP12A ATP4A F2 VWF

Drugs & Therapeutics for Dieulafoy Lesion

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRXâ„¢ Anorectal Wand Unknown status NCT03302858 Phase 2

Search NIH Clinical Center for Dieulafoy Lesion

Genetic Tests for Dieulafoy Lesion

Anatomical Context for Dieulafoy Lesion

MalaCards organs/tissues related to Dieulafoy Lesion:

40
Colon, Small Intestine, Appendix

Publications for Dieulafoy Lesion

Articles related to Dieulafoy Lesion:

(show top 50) (show all 192)
# Title Authors PMID Year
1
Dieulafoy lesion: CT diagnosis of this lesser-known cause of gastrointestinal bleeding. 20 61
25782338 2015
2
Dieulafoy disease of stomach--an uncommon cause of gastrointestinal system bleeding. 20
25856921 2014
3
Dieulafoy lesions as cause of upper gastrointestinal bleeding in a patient with portal hypertension. 61
33552426 2021
4
Dieulafoy disease with gastric MALT lymphoma: A case report. 61
33031327 2020
5
The Final Illness of Herbert Hoover. 61
33111564 2020
6
Dieulafoy lesion in the colon: a rare cause of lower gastrointestinal bleeding. 61
33032351 2020
7
Radio-endoscopic diagnosis of Dieulafoy's lesion in a duodenal diverticulum. 61
32954778 2020
8
Dieulafoy lesion in a Hartmann stump. 61
31943868 2020
9
Gastric Dieulafoy Lesion. 61
32712391 2020
10
Dieulafoy lesions and gastrointestinal bleeding. 61
33100551 2020
11
Rectal Dieulafoy Lesion-a Rare Cause of Lower Gastrointestinal Bleeding. 61
32671803 2020
12
Dieulafoy Lesion: Predictive Factors of Early Relapse and Long-Term Follow-Up. 61
32775545 2020
13
Dieulafoy lesion in the jejunum: a rare cause of massive gastrointestinal bleeding. 61
32850049 2020
14
A Tale of Three Dieulafoy Lesions: A Case Report and Review of the Literature. 61
32617236 2020
15
Dieulafoy lesion: two pediatric case reports. 61
32306992 2020
16
Colonic Dieulafoy lesion successfully treated by endoclips: a rare cause of lower gastrointestinal bleeding. 61
31499536 2020
17
A Jejunal Dieulafoy Lesion: Rare Case Necessitating Surgical Intervention. 61
32698284 2020
18
Neonatal Dieulafoy Lesion Requiring Massive Transfusion Protocol and Surgical Intervention. 61
32325456 2020
19
Heyde Syndrome Complicated by a Dieulafoy Lesion. 61
33071670 2020
20
Dieulafoy lesion of the gallbladder: A rare cause of hemobilia and acute pancreatitis - Case report. 61
31865234 2020
21
Risk Factors for Rebleeding after Emergency Endoscopic Treatment of Dieulafoy Lesion. 61
32908851 2020
22
Introducing GIST and Dieulafoy - Think of Them in GI Bleeding and Anemia. 61
31985905 2019
23
A Rare Cause of Gastrointestinal Bleeding in a 65-Year-Old Man with History of Polycythemia Vera. 61
31824626 2019
24
Dieulafoy Lesion: An Unusual Cause of Excessive Gastric Bleeding in a Neonate. 61
31201025 2019
25
Massive Gastrointestinal Bleeding from a Jejunal Dieulafoy Lesion: An Extraordinary Presentation. 61
31911763 2019
26
Colonoscopy-assisted application of a 14/6t over-the-scope clip for treatment of a bleeding Dieulafoy lesion in the distal jejunum. 61
30736088 2019
27
Successful endoscopic diagnosis and treatment of a Dieulafoy lesion in a large periampullary diverticulum. 61
31021163 2019
28
Massive hemoptysis due to recurrence of bronchial to pulmonary vascular malformation: A case report. 61
30788209 2019
29
[Ovesco clip as a rescue treatment of duodenal Dieulafoy lesion with active bleeding]. 61
30860510 2018
30
Gastric Arteriovenous Malformation with Characteristic Endoscopic Findings. 61
29526928 2018
31
A novel, duodenoscope-friendly endoscopic clip for treating massive upper-GI bleeding secondary to a Dieulafoy lesion. 61
30128389 2018
32
A Dieulafoy's lesion in a duodenal diverticulum. An infrequent cause of UGIB. 61
29421917 2018
33
Gastric Dieulafoy lesion: a rare cause of massive haematemesis in an elderly woman. 61
29545438 2018
34
Two cases of Dieulafoy lesions of the bronchus with novel comorbid associations and endobronchial ablative management. 61
29465555 2018
35
Multidetector-Row Computed Tomography and Colonoscopy for Detecting a Rectal Dieulafoy Lesion as a Source of Lower Gastrointestinal Hemorrhage. 61
29805367 2018
36
Endoscopic Doppler Probe in the Diagnosis and Management of Upper Gastrointestinal Hemorrhage. 61
30280108 2018
37
Atypical appearance of a rectal Dieulafoy lesion. 61
28720476 2018
38
[Gastrointestinal bleeding due to arteriovenous malformation of the jejunum]. 61
29459812 2017
39
Hepatic artery aneurysm: an unusual cause of upper gastrointestinal bleed. 61
28838922 2017
40
Dieulafoy's disease of the bronchial tree: a case report. 61
28562735 2017
41
Acute Gastrointestinal Bleeding Caused by Dieulafoy Lesion of the Esophagus. 61
28865509 2017
42
Minimal Resection of Jejuna Dieulafoy's Lesion Using an Intraoperative Fluoroscopic Localization of the Metallic Coils Used in Angiography. 61
28239082 2017
43
Bronchial Dieulafoy Lesion. A 20-Year History of Unexplained Hemoptysis. 61
27925465 2017
44
Rectal Dieulafoy lesion. 61
26186876 2017
45
Postural Syncope and Constipation: An Unusual Presentation of a Duodenal Dieulafoy's Lesion. 61
28367340 2017
46
Three Year Old Male with Multiple Dieulafoy Lesions Treated with Epinephrine Injections via Therapeutic Endoscopy. 61
28090473 2016
47
Dieulafoy lesion: the little known sleeping giant of gastrointestinal bleeds. 61
27342971 2016
48
Efficacy and safety of TC-325 (HemosprayTM) for non-variceal upper gastrointestinal bleeding at Middlemore Hospital: the early New Zealand experience. 61
27906917 2016
49
Dieulafoy lesion in a two-year-old boy: a case report. 61
27756373 2016
50
Endoscopic submucosal dissection for silent gastric Dieulafoy lesions mimicking gastrointestinal stromal tumors: Report of 7 cases-a case report series. 61
27603399 2016

Variations for Dieulafoy Lesion

Expression for Dieulafoy Lesion

Search GEO for disease gene expression data for Dieulafoy Lesion.

Pathways for Dieulafoy Lesion

Pathways related to Dieulafoy Lesion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.33 VWF F2

GO Terms for Dieulafoy Lesion

Biological processes related to Dieulafoy Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to wounding GO:0009611 9.43 VWF F2
2 hemostasis GO:0007599 9.4 VWF F2
3 potassium ion import across plasma membrane GO:1990573 9.37 ATP4A ATP12A
4 cellular sodium ion homeostasis GO:0006883 9.32 ATP4A ATP12A
5 blood coagulation, intrinsic pathway GO:0007597 9.26 VWF F2
6 sodium ion export across plasma membrane GO:0036376 9.16 ATP4A ATP12A
7 cellular potassium ion homeostasis GO:0030007 8.96 ATP4A ATP12A
8 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP4A ATP12A

Molecular functions related to Dieulafoy Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Dieulafoy Lesion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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