MCID: DLF001
MIFTS: 35

Dieulafoy Lesion

Categories: Blood diseases, Cardiovascular diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Dieulafoy Lesion

MalaCards integrated aliases for Dieulafoy Lesion:

Name: Dieulafoy Lesion 12 53 15
Dieulafoy Lesion of Stomach and Duodenum 12
Dieulafoy's Vascular Malformation 72
Dieulafoy Lesion of Intestine 12
Exulceratio Simplex Dieulafoy 53
Dieulafoy's Lesion 53
Dieulafoy Disease 53

Classifications:



External Ids:

Disease Ontology 12 DOID:12070
ICD9CM 35 537.84
ICD10 33 K31.82
UMLS 72 C0341217 C1135229

Summaries for Dieulafoy Lesion

NIH Rare Diseases : 53 Dieulafoy lesion is an abnormally large artery (a vessel that takes blood from the heart to other areas of the body) in the lining of the gastrointestinal system. It is most common in the stomach but can occur in other locations, including the small and large intestine. Dieulafoy lesions can cause severe and sudden gastrointestinal bleeding. The condition occurs in people of all ages, but is more common in males than in females. Depending upon the site of the bleeding, symptoms may include vomiting up blood (hematemesis); sticky, dark-colored stools (melena); passage of fresh blood in the stool (hematochezia); or coughing up blood (hemoptysis). Some affected individuals may only present with blood pressure problems. Treatment may include endoscopic and/or surgical techniques. Though treatment can be effective, Dieulafoy lesions and the associated blood loss can be fatal, especially if not diagnosed and treated promptly.

MalaCards based summary : Dieulafoy Lesion, also known as dieulafoy lesion of stomach and duodenum, is related to esophageal varix and peptic ulcer disease. An important gene associated with Dieulafoy Lesion is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways is Ion channel transport. The drugs Thrombin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include heart, colon and small intestine, and related phenotype is digestive/alimentary.

Related Diseases for Dieulafoy Lesion

Diseases related to Dieulafoy Lesion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 esophageal varix 29.9 ATP4A ATP12A
2 peptic ulcer disease 29.8 PTGS2 ATP4A
3 active peptic ulcer disease 29.8 PTGS2 ATP4A ATP12A
4 varicose veins 10.2
5 gastric cancer 10.2
6 gastric ulcer 10.1
7 angiodysplasia 10.1
8 purpura 10.1
9 liver disease 10.1
10 von willebrand's disease 10.1
11 syncope 10.1
12 alcohol dependence 10.0
13 alagille syndrome 1 10.0
14 intussusception 10.0
15 thrombocytopenic purpura, autoimmune 10.0
16 pyloric atresia 10.0
17 gastrointestinal stromal tumor 10.0
18 cholangitis, primary sclerosing 10.0
19 portal hypertension 10.0
20 arteriovenous malformation 10.0
21 splenic artery aneurysm 10.0
22 sclerosing cholangitis 10.0
23 hyperuricemia 10.0
24 autoimmune hepatitis 10.0
25 iron metabolism disease 10.0
26 hemangioma 10.0
27 liver cirrhosis 10.0
28 ulcerative colitis 10.0
29 cholangitis 10.0
30 47,xyy 10.0
31 mirizzi syndrome 10.0
32 phace syndrome 10.0
33 thyroid carcinoma 10.0
34 leukemia, acute myeloid 10.0
35 lung disease 10.0
36 meckel diverticulum 10.0
37 myelodysplastic syndrome 10.0
38 mitral valve insufficiency 10.0
39 alcoholic hepatitis 10.0
40 telangiectasis 10.0
41 dilated cardiomyopathy 10.0
42 hellp syndrome 10.0
43 typhoid fever 10.0
44 alcohol use disorder 10.0
45 thrombocytopenia 10.0
46 cholecystitis 10.0
47 constipation 10.0
48 dyspepsia 10.0
49 glomerulonephritis 10.0
50 gastric adenocarcinoma 10.0

Graphical network of the top 20 diseases related to Dieulafoy Lesion:



Diseases related to Dieulafoy Lesion

Symptoms & Phenotypes for Dieulafoy Lesion

MGI Mouse Phenotypes related to Dieulafoy Lesion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.8 ATP12A ATP4A PTGS2

Drugs & Therapeutics for Dieulafoy Lesion

Drugs for Dieulafoy Lesion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 4
2
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
3
Acenocoumarol Approved, Investigational Phase 4 152-72-7 9052 54676537
4
Phylloquinone Approved, Investigational Phase 4 84-80-0
5
Warfarin Approved Phase 4 81-81-2 6691 54678486
6
Dalteparin Approved Phase 4 9005-49-6
7 Bemiparin Approved, Investigational Phase 4 91449-79-5
8
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
9 Menaquinone Investigational Phase 4 1182-68-9
10 Fibrinolytic Agents Phase 4
11 naphthoquinone Phase 4
12 Heparin, Low-Molecular-Weight Phase 4
13 Vitamin K Phase 4
14 Anticoagulants Phase 4
15 calcium heparin Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial to Compare Treatment With Oral Anticoagulation With Antagonists of vitaminK vs Low Molecular Weight Heparin(Bemiparin) in Patients With Anticoagulation Criteria and an Episode of Gastrointestinal Bleeding. Completed NCT01727453 Phase 4 warfarin;Bemiparina

Search NIH Clinical Center for Dieulafoy Lesion

Genetic Tests for Dieulafoy Lesion

Anatomical Context for Dieulafoy Lesion

MalaCards organs/tissues related to Dieulafoy Lesion:

41
Heart, Colon, Small Intestine, Liver, Appendix

Publications for Dieulafoy Lesion

Articles related to Dieulafoy Lesion:

(show top 50) (show all 170)
# Title Authors PMID Year
1
Dieulafoy lesion: CT diagnosis of this lesser-known cause of gastrointestinal bleeding. 38 6
25782338 2015
2
Dieulafoy disease of stomach--an uncommon cause of gastrointestinal system bleeding. 6
25856921 2014
3
Dieulafoy Lesion: An Unusual Cause of Excessive Gastric Bleeding in a Neonate. 38
31201025 2019
4
Successful endoscopic diagnosis and treatment of a Dieulafoy lesion in a large periampullary diverticulum. 38
31021163 2019
5
Colonoscopy-assisted application of a 14/6t over-the-scope clip for treatment of a bleeding Dieulafoy lesion in the distal jejunum. 38
30736088 2019
6
Massive hemoptysis due to recurrence of bronchial to pulmonary vascular malformation: A case report. 38
30788209 2019
7
[Ovesco clip as a rescue treatment of duodenal Dieulafoy lesion with active bleeding]. 38
30860510 2018
8
Gastric Arteriovenous Malformation with Characteristic Endoscopic Findings. 38
29526928 2018
9
A novel, duodenoscope-friendly endoscopic clip for treating massive upper-GI bleeding secondary to a Dieulafoy lesion. 38
30128389 2018
10
A Dieulafoy's lesion in a duodenal diverticulum. An infrequent cause of UGIB. 38
29421917 2018
11
Gastric Dieulafoy lesion: a rare cause of massive haematemesis in an elderly woman. 38
29545438 2018
12
Two cases of Dieulafoy lesions of the bronchus with novel comorbid associations and endobronchial ablative management. 38
29465555 2018
13
Atypical appearance of a rectal Dieulafoy lesion. 38
28720476 2018
14
Multidetector-Row Computed Tomography and Colonoscopy for Detecting a Rectal Dieulafoy Lesion as a Source of Lower Gastrointestinal Hemorrhage. 38
29805367 2018
15
Endoscopic Doppler Probe in the Diagnosis and Management of Upper Gastrointestinal Hemorrhage. 38
30280108 2018
16
[Gastrointestinal bleeding due to arteriovenous malformation of the jejunum]. 38
29459812 2017
17
Hepatic artery aneurysm: an unusual cause of upper gastrointestinal bleed. 38
28838922 2017
18
Dieulafoy's disease of the bronchial tree: a case report. 38
28562735 2017
19
Acute Gastrointestinal Bleeding Caused by Dieulafoy Lesion of the Esophagus. 38
28865509 2017
20
Bronchial Dieulafoy Lesion. A 20-Year History of Unexplained Hemoptysis. 38
27925465 2017
21
Rectal Dieulafoy lesion. 38
26186876 2017
22
Minimal Resection of Jejuna Dieulafoy's Lesion Using an Intraoperative Fluoroscopic Localization of the Metallic Coils Used in Angiography. 38
28239082 2017
23
Postural Syncope and Constipation: An Unusual Presentation of a Duodenal Dieulafoy's Lesion. 38
28367340 2017
24
Three Year Old Male with Multiple Dieulafoy Lesions Treated with Epinephrine Injections via Therapeutic Endoscopy. 38
28090473 2016
25
Dieulafoy lesion: the little known sleeping giant of gastrointestinal bleeds. 38
27342971 2016
26
Efficacy and safety of TC-325 (HemosprayTM) for non-variceal upper gastrointestinal bleeding at Middlemore Hospital: the early New Zealand experience. 38
27906917 2016
27
Dieulafoy lesion in a two-year-old boy: a case report. 38
27756373 2016
28
Endoscopic submucosal dissection for silent gastric Dieulafoy lesions mimicking gastrointestinal stromal tumors: Report of 7 cases-a case report series. 38
27603399 2016
29
Use of the over-the-scope clip to treat massive bleeding at the transitional zone of the anal canal: a case series. 38
26808814 2016
30
Dieulafoy lesion of the gallbladder presenting with bleeding and a pseudo-mirizzi syndrome: A case report and review of the literature. 38
26878358 2016
31
Lower gastrointestinal tract bleeding caused by dieulafoy-like lesion synchronous meckel diverticulum: A rare case report. 38
26601102 2015
32
A single-center United States experience with bleeding Dieulafoy lesions of the small bowel: diagnosis and treatment with single-balloon enteroscopy. 38
26356602 2015
33
Risk Factors for Dieulafoy Lesions in the Upper Gastrointestinal Tract. 38
26064823 2015
34
Appendiceal Dieulafoy lesion: an unusual cause of massive lower gastrointestinal bleeding. 38
25569049 2015
35
Collagenous gastroduodenitis coexisting repeated Dieulafoy ulcer: A case report and review of collagenous gastritis and gastroduodenitis without colonic involvement. 38
26184019 2014
36
Dieulafoy lesion of the appendix. 38
24791666 2014
37
Education and Imaging. Gastroenterology: a bleeding colonic Dieulafoy lesion successfully detected by colonoscopy using a transparent hood. 38
25073630 2014
38
Application of endoscopic hemoclips for nonvariceal upper gastrointestinal bleeding in children. 38
25003673 2014
39
Lethal gastric hemorrhage from a caliber-persistent artery of the antrum - a branch of the right gastric artery. 38
25336884 2014
40
Over-the-scope clip placement is effective rescue therapy for severe acute upper gastrointestinal bleeding. 38
26134611 2014
41
Dieulafoy lesion presenting as severe anaemia in a soldier. 38
24535978 2014
42
Endoscopic ultrasound-guided therapy of a rectal Dieulafoy lesion. 38
24676828 2014
43
Massive lower gastrointestinal bleeding from a jejunal Dieulafoy lesion. 38
25931935 2014
44
Dieulafoy lesion in the ascending colon presenting with gastrointestinal bleeding and severe anemia complicated by a coexisting severe resistant chronic idiopathic thrombocytopenic purpura. 38
25405040 2014
45
Rectal dieulafoy lesions: a rare etiology of chronic lower gastrointestinal bleeding. 38
25349614 2014
46
[A case of cholecysto-gastro-colonic fistula with upper gastrointestinal bleeding]. 38
23756673 2013
47
[A case of Dieulafoy lesion of the jejunum presented with massive hemorrhage]. 38
23756670 2013
48
Adult female with hematemesis-Dieulafoy lesion. 38
23602090 2013
49
Role of endoscopic band ligation in management of non-variceal upper gastrointestinal bleeding. 38
24377156 2013
50
Treatment of a colonic Dieulafoy lesion with endoscopic hemoclipping. 38
23608878 2013

Variations for Dieulafoy Lesion

Expression for Dieulafoy Lesion

Search GEO for disease gene expression data for Dieulafoy Lesion.

Pathways for Dieulafoy Lesion

Pathways related to Dieulafoy Lesion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.12 ATP4A ATP12A

GO Terms for Dieulafoy Lesion

Biological processes related to Dieulafoy Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion transport GO:0006813 9.4 ATP4A ATP12A
2 potassium ion import across plasma membrane GO:1990573 9.37 ATP4A ATP12A
3 ATP hydrolysis coupled proton transport GO:0015991 9.32 ATP4A ATP12A
4 cellular sodium ion homeostasis GO:0006883 9.26 ATP4A ATP12A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP4A ATP12A
6 sodium ion export across plasma membrane GO:0036376 8.96 ATP4A ATP12A
7 cellular potassium ion homeostasis GO:0030007 8.62 ATP4A ATP12A

Molecular functions related to Dieulafoy Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP4A ATP12A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Dieulafoy Lesion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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