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MCID: DLF001
MIFTS: 32

Dieulafoy Lesion

Categories: Blood diseases, Cardiovascular diseases, Gastrointestinal diseases, Rare diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Dieulafoy Lesion

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MalaCards integrated aliases for Dieulafoy Lesion:

Name: Dieulafoy Lesion 12 52 15
Dieulafoy Lesion of Stomach and Duodenum 12
Dieulafoy's Vascular Malformation 71
Dieulafoy Lesion of Intestine 12
Exulceratio Simplex Dieulafoy 52
Dieulafoy's Lesion 52
Dieulafoy Disease 52

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Gastrointestinal diseases Cardiovascular diseases Blood diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12070
ICD9CM 34 537.84
ICD10 32 K31.82
UMLS 71 C0341217 C1135229
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Summaries for Dieulafoy Lesion

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NIH Rare Diseases : 52 Dieulafoy lesion is an abnormally large artery (a vessel that takes blood from the heart to other areas of the body) in the lining of the gastrointestinal system. It is most common in the stomach but can occur in other locations, including the small and large intestine . Dieulafoy lesions can cause severe and sudden gastrointestinal bleeding . The condition occurs in people of all ages, but is more common in males than in females. Depending upon the site of the bleeding, symptoms may include vomiting up blood (hematemesis); sticky, dark-colored stools (melena); passage of fresh blood in the stool (hematochezia); or coughing up blood (hemoptysis). Some affected individuals may only present with blood pressure problems. Treatment may include endoscopic and/or surgical techniques. Though treatment can be effective, Dieulafoy lesions and the associated blood loss can be fatal, especially if not diagnosed and treated promptly.

MalaCards based summary : Dieulafoy Lesion, also known as dieulafoy lesion of stomach and duodenum, is related to active peptic ulcer disease and angiodysplasia. An important gene associated with Dieulafoy Lesion is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit). The drugs Dalteparin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include heart, colon and small intestine.

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Related Diseases for Dieulafoy Lesion

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Diseases related to Dieulafoy Lesion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 active peptic ulcer disease 31.3 ATP4A ATP12A
2 angiodysplasia 30.7 ATP4A ATP12A
3 esophageal varix 30.7 ATP4A ATP12A
4 peptic ulcer disease 30.4 ATP4A ATP12A
5 intestinal volvulus 29.8 ATP4A ATP12A APOLD1
6 diverticulitis 29.8 ATP4A ATP12A APOLD1
7 constipation 29.7 ATP4A ATP12A APOLD1
8 pancreatic vasoactive intestinal peptide producing tumor 10.3 ATP4A ATP12A
9 hemangioma of intra-abdominal structure 10.3 ATP4A ATP12A
10 displacement of cardia through esophageal hiatus 10.3 ATP4A ATP12A
11 gastric hemangioma 10.3 ATP4A ATP12A
12 acquired gastric outlet stenosis 10.3 ATP4A ATP12A
13 benzylpenicillin allergy 10.3 ATP4A ATP12A
14 median arcuate ligament syndrome 10.3 ATP4A ATP12A
15 granulomatous gastritis 10.3 ATP4A ATP12A
16 bacterial esophagitis 10.3 ATP4A ATP12A
17 lingual goiter 10.3 ATP4A ATP12A
18 cascade stomach 10.3 ATP4A ATP12A
19 gastrojejunal ulcer 10.3 ATP4A ATP12A
20 fungal esophagitis 10.3 ATP4A ATP12A
21 gastric gastrinoma 10.3 ATP4A ATP12A
22 fungal gastritis 10.3 ATP4A ATP12A
23 superior mesenteric artery syndrome 10.3 ATP4A ATP12A
24 cervix erosion 10.3 ATP4A ATP12A
25 pneumatosis cystoides intestinalis 10.3 ATP4A ATP12A
26 esophagus sarcoma 10.3 ATP4A ATP12A
27 esophagus melanoma 10.3 ATP4A ATP12A
28 polyposis, skin pigmentation, alopecia, and fingernail changes 10.3 ATP4A ATP12A
29 necrotizing gastritis 10.3 ATP4A ATP12A
30 central nervous system origin vertigo 10.3 ATP4A ATP12A
31 chronic laryngitis 10.3 ATP4A ATP12A
32 laryngitis 10.3 ATP4A ATP12A
33 cefuroxime allergy 10.3 ATP4A ATP12A
34 gastroduodenitis 10.3 ATP4A ATP12A
35 duodenitis 10.3 ATP4A ATP12A
36 chronic intestinal vascular insufficiency 10.3 ATP4A ATP12A
37 peptic ulcer perforation 10.3 ATP4A ATP12A
38 rumination disorder 10.3 ATP4A ATP12A
39 blind loop syndrome 10.3 ATP4A ATP12A
40 crab allergy 10.3 ATP4A ATP12A
41 acute laryngitis 10.3 ATP4A ATP12A
42 duodenal gastrinoma 10.3 ATP4A ATP12A
43 esophageal tuberculosis 10.3 ATP4A ATP12A
44 gastric dilatation 10.3 ATP4A ATP12A
45 diclofenac allergy 10.3 ATP4A ATP12A
46 lymphocytic gastritis 10.3 ATP4A ATP12A
47 duodenal obstruction 10.3 ATP4A ATP12A
48 pancreatic gastrinoma 10.3 ATP4A ATP12A
49 functional diarrhea 10.3 ATP4A ATP12A
50 gastritis, familial giant hypertrophic 10.3 ATP4A ATP12A

Graphical network of the top 20 diseases related to Dieulafoy Lesion:



Diseases related to Dieulafoy Lesion
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Symptoms & Phenotypes for Dieulafoy Lesion

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Drugs & Therapeutics for Dieulafoy Lesion

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Drugs for Dieulafoy Lesion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dalteparin Approved Phase 4 9005-49-6
2
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
3
Warfarin Approved Phase 4 81-81-2 6691 54678486
4 Bemiparin Approved, Investigational Phase 4 91449-79-5
5
Acenocoumarol Approved, Investigational Phase 4 152-72-7 9052 54676537
6
Thrombin Approved, Investigational Phase 4
7
Phylloquinone Approved, Investigational Phase 4 84-80-0
8
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
9 Menaquinone Investigational Phase 4 1182-68-9
10 Fibrinolytic Agents Phase 4
11 Anticoagulants Phase 4
12 naphthoquinone Phase 4
13 Vitamin K Phase 4
14 calcium heparin Phase 4
15 Heparin, Low-Molecular-Weight Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial to Compare Treatment With Oral Anticoagulation With Antagonists of vitaminK vs Low Molecular Weight Heparin(Bemiparin) in Patients With Anticoagulation Criteria and an Episode of Gastrointestinal Bleeding. Completed NCT01727453 Phase 4 warfarin;Bemiparina

Search NIH Clinical Center for Dieulafoy Lesion

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Genetic Tests for Dieulafoy Lesion

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Anatomical Context for Dieulafoy Lesion

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MalaCards organs/tissues related to Dieulafoy Lesion:

40
Heart, Colon, Small Intestine, Liver, Appendix
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Publications for Dieulafoy Lesion

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Articles related to Dieulafoy Lesion:

(show top 50) (show all 172)
# Title Authors PMID Year
1
Dieulafoy lesion: CT diagnosis of this lesser-known cause of gastrointestinal bleeding. 61 52
25782338 2015
2
Dieulafoy disease of stomach--an uncommon cause of gastrointestinal system bleeding. 52
25856921 2014
3
A Rare Cause of Gastrointestinal Bleeding in a 65-Year-Old Man with History of Polycythemia Vera. 61
31824626 2019
4
Dieulafoy Lesion: An Unusual Cause of Excessive Gastric Bleeding in a Neonate. 61
31201025 2019
5
Colonic Dieulafoy lesion successfully treated by endoclips: a rare cause of lower gastrointestinal bleeding. 61
31499536 2019
6
Successful endoscopic diagnosis and treatment of a Dieulafoy lesion in a large periampullary diverticulum. 61
31021163 2019
7
Colonoscopy-assisted application of a 14/6t over-the-scope clip for treatment of a bleeding Dieulafoy lesion in the distal jejunum. 61
30736088 2019
8
Massive hemoptysis due to recurrence of bronchial to pulmonary vascular malformation: A case report. 61
30788209 2019
9
[Ovesco clip as a rescue treatment of duodenal Dieulafoy lesion with active bleeding]. 61
30860510 2018
10
Gastric Arteriovenous Malformation with Characteristic Endoscopic Findings. 61
29526928 2018
11
A novel, duodenoscope-friendly endoscopic clip for treating massive upper-GI bleeding secondary to a Dieulafoy lesion. 61
30128389 2018
12
A Dieulafoy's lesion in a duodenal diverticulum. An infrequent cause of UGIB. 61
29421917 2018
13
Gastric Dieulafoy lesion: a rare cause of massive haematemesis in an elderly woman. 61
29545438 2018
14
Two cases of Dieulafoy lesions of the bronchus with novel comorbid associations and endobronchial ablative management. 61
29465555 2018
15
Atypical appearance of a rectal Dieulafoy lesion. 61
28720476 2018
16
Multidetector-Row Computed Tomography and Colonoscopy for Detecting a Rectal Dieulafoy Lesion as a Source of Lower Gastrointestinal Hemorrhage. 61
29805367 2018
17
Endoscopic Doppler Probe in the Diagnosis and Management of Upper Gastrointestinal Hemorrhage. 61
30280108 2018
18
[Gastrointestinal bleeding due to arteriovenous malformation of the jejunum]. 61
29459812 2017
19
Hepatic artery aneurysm: an unusual cause of upper gastrointestinal bleed. 61
28838922 2017
20
Dieulafoy's disease of the bronchial tree: a case report. 61
28562735 2017
21
Acute Gastrointestinal Bleeding Caused by Dieulafoy Lesion of the Esophagus. 61
28865509 2017
22
Bronchial Dieulafoy Lesion. A 20-Year History of Unexplained Hemoptysis. 61
27925465 2017
23
Rectal Dieulafoy lesion. 61
26186876 2017
24
Minimal Resection of Jejuna Dieulafoy's Lesion Using an Intraoperative Fluoroscopic Localization of the Metallic Coils Used in Angiography. 61
28239082 2017
25
Postural Syncope and Constipation: An Unusual Presentation of a Duodenal Dieulafoy's Lesion. 61
28367340 2017
26
Three Year Old Male with Multiple Dieulafoy Lesions Treated with Epinephrine Injections via Therapeutic Endoscopy. 61
28090473 2016
27
Dieulafoy lesion: the little known sleeping giant of gastrointestinal bleeds. 61
27342971 2016
28
Efficacy and safety of TC-325 (HemosprayTM) for non-variceal upper gastrointestinal bleeding at Middlemore Hospital: the early New Zealand experience. 61
27906917 2016
29
Dieulafoy lesion in a two-year-old boy: a case report. 61
27756373 2016
30
Endoscopic submucosal dissection for silent gastric Dieulafoy lesions mimicking gastrointestinal stromal tumors: Report of 7 cases-a case report series. 61
27603399 2016
31
Use of the over-the-scope clip to treat massive bleeding at the transitional zone of the anal canal: a case series. 61
26808814 2016
32
Dieulafoy lesion of the gallbladder presenting with bleeding and a pseudo-mirizzi syndrome: A case report and review of the literature. 61
26878358 2016
33
Lower gastrointestinal tract bleeding caused by dieulafoy-like lesion synchronous meckel diverticulum: A rare case report. 61
26601102 2015
34
A single-center United States experience with bleeding Dieulafoy lesions of the small bowel: diagnosis and treatment with single-balloon enteroscopy. 61
26356602 2015
35
Risk Factors for Dieulafoy Lesions in the Upper Gastrointestinal Tract. 61
26064823 2015
36
Appendiceal Dieulafoy lesion: an unusual cause of massive lower gastrointestinal bleeding. 61
25569049 2015
37
Collagenous gastroduodenitis coexisting repeated Dieulafoy ulcer: A case report and review of collagenous gastritis and gastroduodenitis without colonic involvement. 61
26184019 2014
38
Dieulafoy lesion of the appendix. 61
24791666 2014
39
Education and Imaging. Gastroenterology: a bleeding colonic Dieulafoy lesion successfully detected by colonoscopy using a transparent hood. 61
25073630 2014
40
Application of endoscopic hemoclips for nonvariceal upper gastrointestinal bleeding in children. 61
25003673 2014
41
Lethal gastric hemorrhage from a caliber-persistent artery of the antrum - a branch of the right gastric artery. 61
25336884 2014
42
Over-the-scope clip placement is effective rescue therapy for severe acute upper gastrointestinal bleeding. 61
26134611 2014
43
Dieulafoy lesion presenting as severe anaemia in a soldier. 61
24535978 2014
44
Endoscopic ultrasound-guided therapy of a rectal Dieulafoy lesion. 61
24676828 2014
45
Massive lower gastrointestinal bleeding from a jejunal Dieulafoy lesion. 61
25931935 2014
46
Dieulafoy lesion in the ascending colon presenting with gastrointestinal bleeding and severe anemia complicated by a coexisting severe resistant chronic idiopathic thrombocytopenic purpura. 61
25405040 2014
47
Rectal dieulafoy lesions: a rare etiology of chronic lower gastrointestinal bleeding. 61
25349614 2014
48
[A case of cholecysto-gastro-colonic fistula with upper gastrointestinal bleeding]. 61
23756673 2013
49
[A case of Dieulafoy lesion of the jejunum presented with massive hemorrhage]. 61
23756670 2013
50
Adult female with hematemesis-Dieulafoy lesion. 61
23602090 2013
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Variations for Dieulafoy Lesion

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Expression for Dieulafoy Lesion

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Search GEO for disease gene expression data for Dieulafoy Lesion.
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Pathways for Dieulafoy Lesion

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GO Terms for Dieulafoy Lesion

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Biological processes related to Dieulafoy Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.32 ATP4A ATP12A
2 cellular sodium ion homeostasis GO:0006883 9.26 ATP4A ATP12A
3 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.16 ATP4A ATP12A
4 sodium ion export across plasma membrane GO:0036376 8.96 ATP4A ATP12A
5 cellular potassium ion homeostasis GO:0030007 8.62 ATP4A ATP12A

Molecular functions related to Dieulafoy Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A
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Sources for Dieulafoy Lesion

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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