MCID: DLF001
MIFTS: 32

Dieulafoy Lesion

Categories: Blood diseases, Cardiovascular diseases, Gastrointestinal diseases, Rare diseases

Aliases & Classifications for Dieulafoy Lesion

MalaCards integrated aliases for Dieulafoy Lesion:

Name: Dieulafoy Lesion 12 52 15
Dieulafoy Lesion of Stomach and Duodenum 12
Dieulafoy's Vascular Malformation 71
Dieulafoy Lesion of Intestine 12
Exulceratio Simplex Dieulafoy 52
Dieulafoy's Lesion 52
Dieulafoy Disease 52

Classifications:



External Ids:

Disease Ontology 12 DOID:12070
ICD9CM 34 537.84
ICD10 32 K31.82
UMLS 71 C0341217 C1135229

Summaries for Dieulafoy Lesion

NIH Rare Diseases : 52 Dieulafoy lesion is an abnormally large artery (a vessel that takes blood from the heart to other areas of the body) in the lining of the gastrointestinal system. It is most common in the stomach but can occur in other locations, including the small and large intestine . Dieulafoy lesions can cause severe and sudden gastrointestinal bleeding . The condition occurs in people of all ages, but is more common in males than in females. Depending upon the site of the bleeding, symptoms may include vomiting up blood (hematemesis); sticky, dark-colored stools (melena); passage of fresh blood in the stool (hematochezia); or coughing up blood (hemoptysis). Some affected individuals may only present with blood pressure problems. Treatment may include endoscopic and/or surgical techniques. Though treatment can be effective, Dieulafoy lesions and the associated blood loss can be fatal, especially if not diagnosed and treated promptly.

MalaCards based summary : Dieulafoy Lesion, also known as dieulafoy lesion of stomach and duodenum, is related to active peptic ulcer disease and esophageal varix. An important gene associated with Dieulafoy Lesion is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit). The drugs Heparin and Phylloquinone have been mentioned in the context of this disorder. Affiliated tissues include heart, colon and small intestine.

Related Diseases for Dieulafoy Lesion

Diseases related to Dieulafoy Lesion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 active peptic ulcer disease 31.2 ATP4A ATP12A
2 esophageal varix 30.6 ATP4A ATP12A
3 angiodysplasia 30.6 ATP4A ATP12A
4 peptic ulcer disease 30.3 ATP4A ATP12A
5 dysentery 30.1 ATP4A ATP12A
6 constipation 29.8 ATP4A ATP12A APOLD1
7 volvulus of midgut 29.8 ATP4A ATP12A APOLD1
8 diverticulitis 29.8 ATP4A ATP12A APOLD1
9 vagus nerve disease 10.3 ATP4A ATP12A
10 hemangioma of intra-abdominal structure 10.3 ATP4A ATP12A
11 acquired gastric outlet stenosis 10.3 ATP4A ATP12A
12 displacement of cardia through esophageal hiatus 10.3 ATP4A ATP12A
13 angiodysplasia of intestine 10.3 ATP4A ATP12A
14 benzylpenicillin allergy 10.3 ATP4A ATP12A
15 penicillin allergy 10.3 ATP4A ATP12A
16 granulomatous gastritis 10.3 ATP4A ATP12A
17 bacterial esophagitis 10.3 ATP4A ATP12A
18 lingual goiter 10.3 ATP4A ATP12A
19 cascade stomach 10.3 ATP4A ATP12A
20 gastrojejunal ulcer 10.3 ATP4A ATP12A
21 median arcuate ligament syndrome 10.3 ATP4A ATP12A
22 laryngeal tuberculosis 10.3 ATP4A ATP12A
23 fungal esophagitis 10.3 ATP4A ATP12A
24 esophagus melanoma 10.3 ATP4A ATP12A
25 emphysematous cholecystitis 10.3 ATP4A ATP12A
26 necrotizing gastritis 10.3 ATP4A ATP12A
27 cervix erosion 10.3 ATP4A ATP12A
28 pneumatosis cystoides intestinalis 10.3 ATP4A ATP12A
29 gastric gastrinoma 10.3 ATP4A ATP12A
30 superior mesenteric artery syndrome 10.3 ATP4A ATP12A
31 chronic laryngitis 10.3 ATP4A ATP12A
32 laryngitis 10.3 ATP4A ATP12A
33 cefuroxime allergy 10.3 ATP4A ATP12A
34 polyposis, skin pigmentation, alopecia, and fingernail changes 10.3 ATP4A ATP12A
35 chronic intestinal vascular insufficiency 10.3 ATP4A ATP12A
36 peptic ulcer perforation 10.3 ATP4A ATP12A
37 rumination disorder 10.3 ATP4A ATP12A
38 blind loop syndrome 10.3 ATP4A ATP12A
39 acute laryngitis 10.3 ATP4A ATP12A
40 gastroduodenitis 10.3 ATP4A ATP12A
41 duodenitis 10.3 ATP4A ATP12A
42 duodenal gastrinoma 10.3 ATP4A ATP12A
43 gastric hemangioma 10.3 ATP4A ATP12A
44 pancreatic gastrinoma 10.3 ATP4A ATP12A
45 gastric dilatation 10.3 ATP4A ATP12A
46 scalp dermatosis 10.3 ATP4A ATP12A
47 central nervous system origin vertigo 10.3 ATP4A ATP12A
48 diclofenac allergy 10.3 ATP4A ATP12A
49 lymphocytic gastritis 10.3 ATP4A ATP12A
50 x-linked chondrodysplasia punctata 1 10.3 ATP4A ATP12A

Graphical network of the top 20 diseases related to Dieulafoy Lesion:



Diseases related to Dieulafoy Lesion

Symptoms & Phenotypes for Dieulafoy Lesion

Drugs & Therapeutics for Dieulafoy Lesion

Drugs for Dieulafoy Lesion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
2
Phylloquinone Approved, Investigational Phase 4 84-80-0
3
Acenocoumarol Approved, Investigational Phase 4 152-72-7 9052 54676537
4
Thrombin Approved, Investigational Phase 4
5
Warfarin Approved Phase 4 81-81-2 6691 54678486
6
Tinzaparin Approved Phase 4 9041-08-1, 9005-49-6 25244225
7
Dalteparin Approved Phase 4 9005-49-6
8 Bemiparin Approved, Investigational Phase 4 91449-79-5
9
Menadione Approved, Nutraceutical Phase 4 58-27-5 4055
10 Menaquinone Investigational Phase 4 1182-68-9
11 Anticoagulants Phase 4
12 Heparin, Low-Molecular-Weight Phase 4
13 Vitamin K Phase 4
14 naphthoquinone Phase 4
15 calcium heparin Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial to Compare Treatment With Oral Anticoagulation With Antagonists of vitaminK vs Low Molecular Weight Heparin(Bemiparin) in Patients With Anticoagulation Criteria and an Episode of Gastrointestinal Bleeding. Completed NCT01727453 Phase 4 warfarin;Bemiparina
2 Role of Balloon-Assisted Enteroscopy (BAE) in Diagnosis and Treatment of Small Intestinal Disorders Not yet recruiting NCT04288882

Search NIH Clinical Center for Dieulafoy Lesion

Genetic Tests for Dieulafoy Lesion

Anatomical Context for Dieulafoy Lesion

MalaCards organs/tissues related to Dieulafoy Lesion:

40
Heart, Colon, Small Intestine, Liver, Appendix

Publications for Dieulafoy Lesion

Articles related to Dieulafoy Lesion:

(show top 50) (show all 178)
# Title Authors PMID Year
1
Dieulafoy lesion: CT diagnosis of this lesser-known cause of gastrointestinal bleeding. 52 61
25782338 2015
2
Dieulafoy disease of stomach--an uncommon cause of gastrointestinal system bleeding. 52
25856921 2014
3
Dieulafoy lesion: two pediatric case reports. 61
32306992 2020
4
Neonatal Dieulafoy Lesion Requiring Massive Transfusion Protocol and Surgical Intervention. 61
32325456 2020
5
Colonic Dieulafoy lesion successfully treated by endoclips: a rare cause of lower gastrointestinal bleeding. 61
31499536 2020
6
Dieulafoy lesion of the gallbladder: A rare cause of hemobilia and acute pancreatitis - Case report. 61
31865234 2020
7
Dieulafoy lesion in a Hartmann stump. 61
31943868 2020
8
Introducing GIST and Dieulafoy - Think of Them in GI Bleeding and Anemia. 61
31985905 2019
9
A Rare Cause of Gastrointestinal Bleeding in a 65-Year-Old Man with History of Polycythemia Vera. 61
31824626 2019
10
Dieulafoy Lesion: An Unusual Cause of Excessive Gastric Bleeding in a Neonate. 61
31201025 2019
11
Massive Gastrointestinal Bleeding from a Jejunal Dieulafoy Lesion: An Extraordinary Presentation. 61
31911763 2019
12
Successful endoscopic diagnosis and treatment of a Dieulafoy lesion in a large periampullary diverticulum. 61
31021163 2019
13
Colonoscopy-assisted application of a 14/6t over-the-scope clip for treatment of a bleeding Dieulafoy lesion in the distal jejunum. 61
30736088 2019
14
Massive hemoptysis due to recurrence of bronchial to pulmonary vascular malformation: A case report. 61
30788209 2019
15
[Ovesco clip as a rescue treatment of duodenal Dieulafoy lesion with active bleeding]. 61
30860510 2018
16
Gastric Arteriovenous Malformation with Characteristic Endoscopic Findings. 61
29526928 2018
17
A novel, duodenoscope-friendly endoscopic clip for treating massive upper-GI bleeding secondary to a Dieulafoy lesion. 61
30128389 2018
18
A Dieulafoy's lesion in a duodenal diverticulum. An infrequent cause of UGIB. 61
29421917 2018
19
Gastric Dieulafoy lesion: a rare cause of massive haematemesis in an elderly woman. 61
29545438 2018
20
Two cases of Dieulafoy lesions of the bronchus with novel comorbid associations and endobronchial ablative management. 61
29465555 2018
21
Atypical appearance of a rectal Dieulafoy lesion. 61
28720476 2018
22
Multidetector-Row Computed Tomography and Colonoscopy for Detecting a Rectal Dieulafoy Lesion as a Source of Lower Gastrointestinal Hemorrhage. 61
29805367 2018
23
Endoscopic Doppler Probe in the Diagnosis and Management of Upper Gastrointestinal Hemorrhage. 61
30280108 2018
24
[Gastrointestinal bleeding due to arteriovenous malformation of the jejunum]. 61
29459812 2017
25
Hepatic artery aneurysm: an unusual cause of upper gastrointestinal bleed. 61
28838922 2017
26
Dieulafoy's disease of the bronchial tree: a case report. 61
28562735 2017
27
Acute Gastrointestinal Bleeding Caused by Dieulafoy Lesion of the Esophagus. 61
28865509 2017
28
Bronchial Dieulafoy Lesion. A 20-Year History of Unexplained Hemoptysis. 61
27925465 2017
29
Rectal Dieulafoy lesion. 61
26186876 2017
30
Minimal Resection of Jejuna Dieulafoy's Lesion Using an Intraoperative Fluoroscopic Localization of the Metallic Coils Used in Angiography. 61
28239082 2017
31
Postural Syncope and Constipation: An Unusual Presentation of a Duodenal Dieulafoy's Lesion. 61
28367340 2017
32
Dieulafoy lesion: the little known sleeping giant of gastrointestinal bleeds. 61
27342971 2016
33
Three Year Old Male with Multiple Dieulafoy Lesions Treated with Epinephrine Injections via Therapeutic Endoscopy. 61
28090473 2016
34
Efficacy and safety of TC-325 (HemosprayTM) for non-variceal upper gastrointestinal bleeding at Middlemore Hospital: the early New Zealand experience. 61
27906917 2016
35
Dieulafoy lesion in a two-year-old boy: a case report. 61
27756373 2016
36
Endoscopic submucosal dissection for silent gastric Dieulafoy lesions mimicking gastrointestinal stromal tumors: Report of 7 cases-a case report series. 61
27603399 2016
37
Use of the over-the-scope clip to treat massive bleeding at the transitional zone of the anal canal: a case series. 61
26808814 2016
38
Dieulafoy lesion of the gallbladder presenting with bleeding and a pseudo-mirizzi syndrome: A case report and review of the literature. 61
26878358 2016
39
Lower gastrointestinal tract bleeding caused by dieulafoy-like lesion synchronous meckel diverticulum: A rare case report. 61
26601102 2015
40
A single-center United States experience with bleeding Dieulafoy lesions of the small bowel: diagnosis and treatment with single-balloon enteroscopy. 61
26356602 2015
41
Risk Factors for Dieulafoy Lesions in the Upper Gastrointestinal Tract. 61
26064823 2015
42
Appendiceal Dieulafoy lesion: an unusual cause of massive lower gastrointestinal bleeding. 61
25569049 2015
43
Collagenous gastroduodenitis coexisting repeated Dieulafoy ulcer: A case report and review of collagenous gastritis and gastroduodenitis without colonic involvement. 61
26184019 2014
44
Dieulafoy lesion of the appendix. 61
24791666 2014
45
Education and Imaging. Gastroenterology: a bleeding colonic Dieulafoy lesion successfully detected by colonoscopy using a transparent hood. 61
25073630 2014
46
Lethal gastric hemorrhage from a caliber-persistent artery of the antrum - a branch of the right gastric artery. 61
25336884 2014
47
Application of endoscopic hemoclips for nonvariceal upper gastrointestinal bleeding in children. 61
25003673 2014
48
Over-the-scope clip placement is effective rescue therapy for severe acute upper gastrointestinal bleeding. 61
26134611 2014
49
Dieulafoy lesion presenting as severe anaemia in a soldier. 61
24535978 2014
50
Massive lower gastrointestinal bleeding from a jejunal Dieulafoy lesion. 61
25931935 2014

Variations for Dieulafoy Lesion

Expression for Dieulafoy Lesion

Search GEO for disease gene expression data for Dieulafoy Lesion.

Pathways for Dieulafoy Lesion

GO Terms for Dieulafoy Lesion

Biological processes related to Dieulafoy Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.32 ATP4A ATP12A
2 cellular sodium ion homeostasis GO:0006883 9.26 ATP4A ATP12A
3 sodium ion export across plasma membrane GO:0036376 9.16 ATP4A ATP12A
4 cellular potassium ion homeostasis GO:0030007 8.96 ATP4A ATP12A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP4A ATP12A

Molecular functions related to Dieulafoy Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Dieulafoy Lesion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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