MCID: DFF036
MIFTS: 52

Differentiated Thyroid Carcinoma

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Differentiated Thyroid Carcinoma

MalaCards integrated aliases for Differentiated Thyroid Carcinoma:

Name: Differentiated Thyroid Carcinoma 58 17
Papillary or Follicular Thyroid Carcinoma 58
Differentiated Thyroid Gland Carcinoma 71
Well-Differentiated Thyroid Carcinoma 58

Characteristics:

Orphanet epidemiological data:

58
differentiated thyroid carcinoma
Inheritance: Not applicable; Prevalence: 1-9/100000 (Worldwide),1-9/100000 (Europe); Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare endocrine diseases


External Ids:

ICD10 via Orphanet 33 C73
UMLS via Orphanet 72 C0238463
Orphanet 58 ORPHA146
UMLS 71 C1337013

Summaries for Differentiated Thyroid Carcinoma

MalaCards based summary : Differentiated Thyroid Carcinoma, also known as papillary or follicular thyroid carcinoma, is related to thyroid carcinoma and goiter. An important gene associated with Differentiated Thyroid Carcinoma is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are Nanog in Mammalian ESC Pluripotency and Parkinson disease. The drugs Hormones and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and bone, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Differentiated Thyroid Carcinoma

Diseases related to Differentiated Thyroid Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 282)
# Related Disease Score Top Affiliating Genes
1 thyroid carcinoma 31.7 RET PCM1 NTRK1 NCOA4 HRAS CCDC6
2 goiter 31.2 RET PAX8 HRAS
3 thyroid cancer, nonmedullary, 2 31.2 PPARG PAX8 NRAS HRAS BRAF
4 thyroiditis 31.2 RET NCOA4 HRAS BRAF
5 nodular goiter 30.8 RET HRAS BRAF
6 papillary carcinoma 30.7 RET PPARG PAX8 NTRK1 NCOA4 CCDC6
7 thyroid tumor 30.7 RET NRAS KRAS HRAS BRAF
8 multinodular goiter 30.7 RET PAX8 HRAS
9 thyroid carcinoma, familial medullary 30.6 RET NTRK1 KRAS BRAF
10 thyroid gland disease 30.5 RET PPARG PAX8 NCOA4
11 histiocytosis 30.3 NRAS BRAF ALK
12 struma ovarii 30.2 RET NCOA4 KRAS BRAF
13 thyroid gland medullary carcinoma 30.2 RET PAX8 NTRK1 NCOA4 CCDC6
14 follicular adenoma 29.9 RET PPARG PAX8 NTRK1 HRAS BRAF
15 myeloid leukemia 29.7 PCM1 NRAS KRAS HRAS ETV6
16 thyroid gland anaplastic carcinoma 29.3 RET PPARG PAX8 NTRK1 NRAS NCOA4
17 renal cell carcinoma, papillary, 1 29.3 RET PAX8 NTRK1 NRAS HRAS BRAF
18 thyroid gland cancer 29.2 RET PPARG PAX8 NTRK1 NRAS NCOA4
19 neuroblastoma 29.2 RET PPARG NTRK3 NTRK1 NRAS HRAS
20 lung cancer susceptibility 3 28.9 RET NTRK3 NTRK1 NRAS KRAS HRAS
21 thyroid cancer, nonmedullary, 1 10.7
22 urachal adenocarcinoma 10.6 KRAS BRAF
23 hyperplastic polyposis syndrome 10.6 KRAS BRAF
24 melphalan allergy 10.6 NRAS BRAF
25 apocrine adenoma 10.6 KRAS BRAF
26 hypothyroidism 10.6
27 spitz nevus 10.6 HRAS BRAF
28 signet ring basal cell carcinoma 10.6 KRAS HRAS
29 hyperthyroidism 10.6
30 trachea carcinoma in situ 10.6 KRAS HRAS
31 cobblestone retinal degeneration 10.6 KRAS HRAS
32 nasal cavity adenocarcinoma 10.6 KRAS HRAS
33 hypoparathyroidism 10.5
34 pulmonic stenosis 10.5 KRAS HRAS BRAF
35 ampulla of vater neoplasm 10.5 KRAS HRAS
36 villous adenoma 10.5 KRAS HRAS BRAF
37 syringocystadenoma papilliferum 10.5 KRAS BRAF
38 descending colon cancer 10.5 KRAS HRAS
39 costello syndrome 10.5 KRAS HRAS BRAF
40 periampullary adenoma 10.5 KRAS HRAS
41 nodular malignant melanoma 10.5 NRAS HRAS BRAF
42 transverse colon cancer 10.5 KRAS HRAS
43 pregnancy adenoma 10.5 NTRK3 ETV6
44 acral lentiginous melanoma 10.5 NRAS HRAS BRAF
45 malignant anus melanoma 10.5 NRAS HRAS
46 appendiceal neoplasm 10.5 KRAS HRAS
47 gallbladder benign neoplasm 10.5 KRAS HRAS
48 adenosquamous lung carcinoma 10.5 KRAS HRAS ALK
49 malignant dermis tumor 10.5 NRAS HRAS
50 cellular congenital mesoblastic nephroma 10.5 NTRK3 ETV6

Graphical network of the top 20 diseases related to Differentiated Thyroid Carcinoma:



Diseases related to Differentiated Thyroid Carcinoma

Symptoms & Phenotypes for Differentiated Thyroid Carcinoma

GenomeRNAi Phenotypes related to Differentiated Thyroid Carcinoma according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 10.64 HRAS KRAS BRAF
2 Decreased viability GR00055-A-2 10.64 HRAS KRAS BRAF
3 Decreased viability GR00055-A-3 10.64 KRAS
4 Decreased viability GR00106-A-0 10.64 KRAS
5 Decreased viability GR00221-A-1 10.64 HRAS KRAS PPARG RET ALK NRAS
6 Decreased viability GR00221-A-2 10.64 HRAS KRAS NTRK3 PPARG RET
7 Decreased viability GR00221-A-3 10.64 HRAS PPARG NTRK1 NRAS
8 Decreased viability GR00221-A-4 10.64 NTRK3 PPARG RET BRAF ALK
9 Decreased viability GR00249-S 10.64 BRAF NTRK1 ALK
10 Decreased viability GR00301-A 10.64 KRAS RET BRAF NTRK1
11 Decreased viability GR00381-A-1 10.64 KRAS BRAF
12 Decreased viability GR00386-A-1 10.64 PPARG
13 Decreased viability GR00402-S-2 10.64 RET
14 Decreased cell migration GR00055-A-1 9.46 ALK NTRK1
15 Decreased cell migration GR00055-A-3 9.46 BRAF HRAS
16 Reduced mammosphere formation GR00396-S 9.28 BRAF CCDC6 EIF1AX ETV6 HRAS KRAS

MGI Mouse Phenotypes related to Differentiated Thyroid Carcinoma:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.37 ALK BRAF ETV6 GOLGA5 HRAS KRAS
2 behavior/neurological MP:0005386 10.34 ALK BRAF GOLGA5 HRAS KRAS NRAS
3 mortality/aging MP:0010768 10.31 ALK BRAF CCDC6 ERC1 ETV6 GOLGA5
4 homeostasis/metabolism MP:0005376 10.27 ALK BRAF ERC1 ETV6 HRAS KRAS
5 cardiovascular system MP:0005385 10.25 BRAF ETV6 HRAS KRAS LPAR4 NRAS
6 embryo MP:0005380 10.22 BRAF ETV6 GOLGA5 KRAS LPAR4 NDUFA13
7 endocrine/exocrine gland MP:0005379 10.16 ALK BRAF ETV6 HRAS KRAS NRAS
8 craniofacial MP:0005382 10.14 BRAF GOLGA5 HRAS KRAS LPAR4 NRAS
9 integument MP:0010771 10.13 ALK BRAF ETV6 HRAS KRAS LPAR4
10 no phenotypic analysis MP:0003012 10.02 ERC1 ETV6 HRAS KRAS NRAS NTRK1
11 normal MP:0002873 10 BRAF ERC1 ETV6 HRAS KRAS NRAS
12 neoplasm MP:0002006 9.97 ALK BRAF ETV6 HRAS KRAS NRAS
13 hearing/vestibular/ear MP:0005377 9.95 BRAF KRAS NTRK1 NTRK3 PAX8 PPARG
14 pigmentation MP:0001186 9.63 ALK BRAF KRAS NRAS NTRK1 PCM1
15 reproductive system MP:0005389 9.61 ALK BRAF GOLGA5 KRAS NTRK3 PAX8
16 skeleton MP:0005390 9.32 ALK BRAF GOLGA5 HRAS KRAS LPAR4

Drugs & Therapeutics for Differentiated Thyroid Carcinoma

Drugs for Differentiated Thyroid Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Phase 3
2 Hormone Antagonists Phase 3
3
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
4
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
5
Everolimus Approved Phase 2 159351-69-6 70789204 6442177
6
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
7
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
8
Lithium carbonate Approved Phase 2 554-13-2
9
Ipilimumab Approved Phase 2 477202-00-9
10
nivolumab Approved Phase 2 946414-94-4
11
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
12
Lenalidomide Approved Phase 1, Phase 2 191732-72-6 216326
13
Iodine Approved, Investigational Phase 2 7553-56-2 807
14
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
15
Folic acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
16
Cediranib Investigational Phase 1, Phase 2 288383-20-0 9933475
17
Maleic acid Experimental, Investigational Phase 1, Phase 2 110-17-8, 110-16-7 444972
18
Liposomal doxorubicin Phase 2 31703
19 Micronutrients Phase 2
20 Trace Elements Phase 2
21 Alpha-lipoic Acid Phase 2
22 Vitamins Phase 2
23 Vitamin B Complex Phase 2
24 Antioxidants Phase 2
25 Thioctic Acid Phase 2
26 Folate Phase 2
27 Nutrients Phase 2
28 Vitamin B9 Phase 2
29 Protective Agents Phase 2
30 Immunosuppressive Agents Phase 2
31 Radiopharmaceuticals Phase 2
32 Analgesics, Non-Narcotic Phase 2
33 Cyclooxygenase 2 Inhibitors Phase 2
34 Analgesics Phase 2
35 Cyclooxygenase Inhibitors Phase 2
36 Antirheumatic Agents Phase 2
37 Anti-Inflammatory Agents Phase 2
38 Anti-Inflammatory Agents, Non-Steroidal Phase 2
39 Mitogens Phase 2
40 Fluorides Phase 2
41 Endothelial Growth Factors Phase 2
42 Anti-Infective Agents Phase 2
43 Antiviral Agents Phase 2
44 Antimetabolites Phase 2
45 Psychotropic Drugs Phase 2
46 Antidepressive Agents Phase 2
47
Apatinib Phase 2 811803-05-1
48 Antibodies, Monoclonal Phase 2
49 Antineoplastic Agents, Immunological Phase 2
50 Angiogenesis Inhibitors Phase 2

Interventional clinical trials:

(show top 50) (show all 52)
# Name Status NCT ID Phase Drugs
1 Total Thyroidectomy With Harmonic Scalpel® Versus Standard Surgery. Open Multicentric Randomized Controlled Trial Unknown status NCT00385983 Phase 4
2 Medico-Economic Comparison of Four Strategies of Radioiodine Ablation in Thyroid Carcinoma Patients - Estimabl Unknown status NCT00435851 Phase 3 Thyrogen, thyroid hormone withdrawal, iode 131
3 Phase 3 Trial of Adjuvant External Beam Radiotherapy for Locally Invasive Differentiated Thyroid Carcinoma Completed NCT00144079 Phase 3
4 A Prospective, Multicenter, Open Label Phase Ⅱ Clinical Trial of Doxorubicin Hydrochloride Liposome Injection Combined With Cisplatin in the Treatment of Advanced Poorly Differentiated Thyroid Carcinoma Unknown status NCT03387943 Phase 2 PLD;Cisplatin
5 Clinical Trial to Evaluate Efficacy of Redifferentiation Therapy Using Alpha-lipoic Acid in Thyroid Cancer Patients With Decreased Radioactive Iodine Uptake Unknown status NCT01396733 Phase 2 alpha-lipoic acids
6 A Phase II Study to Investigate the Efficacy of RAD001 (Afinitor®, Everolimus) in Patients With Irresectable Recurrent or Metastatic Differentiated, Undifferentiated (Anaplastic) and Medullary Thyroid Carcinoma Unknown status NCT01118065 Phase 2 everolimus
7 Phase II Study of Sunitinib in Iodine Refractory Differentiated Thyroid Cancer and Metastatic Medullary Carcinoma of Thyroid With Functional Imaging Correlation Completed NCT00519896 Phase 2 sunitinib malate
8 A Multi-center , Opened, Phase II Study of Safety and Efficacy of Sulfatinib in Advanced Medullary Thyroid Carcinoma ( MTC) and Iodine-refractory Differentiated Thyroid Carcinoma (DTC) Completed NCT02614495 Phase 2 Surufatinib
9 Preliminary Study of the Interest of Diffusion-weighted Magnetic Resonance Imaging in the Early Detection of Differentiated Thyroid Carcinoma Cervical Recurrence. Comparison with18F-FDG PET/CT Completed NCT02515084 Phase 2
10 Phase II Study Of Celecoxib In Metastatic Differentiated Thyroid Carcinoma Completed NCT00061906 Phase 2 celecoxib
11 Phase II Study of Cabozantinib in Patients With Radioiodine-Refractory Differentiated Thyroid Cancer Who Progressed on Prior VEGFR-Targeted Therapy Completed NCT01811212 Phase 2 Cabozantinib S-malate
12 A Phase II Study of Bortezomib in Metastatic Papillary Thyroid Carcinoma or Follicular Thyroid Carcinoma Completed NCT00104871 Phase 2 Bortezomib
13 A Phase II Trial of 17-Allylaminogeldanamycin (17AAG) in Advanced Medullary and Differentiated Thyroid Carcinoma Completed NCT00118248 Phase 2 tanespimycin
14 A Randomized, Multicenter, Open-label, Phase II Study of the Optimal Scheme of Administration of Pazopanib in Thyroid Carcinoma Completed NCT01813136 Phase 2 Continuous pazopanib (Arm A);Intermittent pazopanib (Arm B)
15 Sorafenib as Adjuvant to Radioiodine Therapy in Non-Medullary Thyroid Carcinoma Completed NCT00887107 Phase 2 Sorafenib (nexavar)
16 A Phase II Study of External Beam Radiotherapy for Locoregionally Advanced or Recurrent Differentiated Thyroid Carcinoma Completed NCT01173289 Phase 2
17 A Phase II Study of Single Agent Intravenous (IV) VEGF Trap in Patients With Poor Prognostic Recurrent and/or Metastatic Thyroid Cancer After RAI Therapy Completed NCT00729157 Phase 2
18 The Effects of Lithium Carbonate on Low Dose Radioiodine Ablation in Early Thyroid Cancer Treatment Completed NCT00251316 Phase 2 Lithium Carbonate;Placebo
19 Phase 2 of Sunitinib (Sutent) in Patients With Locally Advanced or Metastatic Anaplastic, Differentiated or Medullar Thyroid Cancer Completed NCT00510640 Phase 2 Sunitinib
20 A Phase 2 Study of Lenvatinib in Combination With Radioactive Iodine Therapy in Patients With Progressive RAI-Sensitive Differentiated Thyroid Cancer Recruiting NCT03506048 Phase 2 Lenvatinib
21 The Effectiveness and Safety of Apatinib Mesylate in Locally Advanced/Metastatic Differentiated Thyroid Carcinoma: a Phase 2 Trial. Recruiting NCT03167385 Phase 2 Apatinib Mesylate
22 Phase II Study of XL184 (Cabozantinib) in Combination With Nivolumab and Ipilimumab (CaboNivoIpi) in Patients With Radioiodine-Refractory Differentiated Thyroid Cancer Whose Cancer Progressed After One Prior VEGFR-Targeted Therapy Recruiting NCT03914300 Phase 2 Cabozantinib S-malate
23 A Randomized, Double Blind, Placebo-controlled Phase II, Multi-Centre Study to Assess the Efficacy and Safety of Vandetanib (ZD6474) in Patients With Locally Advanced or Metastatic Papillary or Follicular Thyroid Carcinoma Failing or Unsuitable for Radioiodine Therapy Active, not recruiting NCT00537095 Phase 2 Vandetanib
24 A Phase II Trial of Cabozantinib for the Treatment of Radioiodine (RAI)-Refractory Differentiated Thyroid Carcinoma (DTC) in the First-line Setting Active, not recruiting NCT02041260 Phase 2 Cabozantinib
25 Phase II Trial of Sunitinib (SU11248) in Iodine-131 Refractory, Unresectable Differentiated Thyroid Cancers and Medullary Thyroid Cancers Active, not recruiting NCT00381641 Phase 2 Sunitinib;Sunitinib Malate
26 Phase I/II Trial of Cediranib Alone or Cediranib and Lenalidomide in Iodine 131-Refractory Differentiated Thyroid Cancer Active, not recruiting NCT01208051 Phase 1, Phase 2 Cediranib;Cediranib Maleate;Lenalidomide
27 Sorafenib in Patients With Hepatopulmonary Syndrome: A Double-Blind Randomized Clinical Trial Terminated NCT02021929 Phase 2 Sorafenib;Placebo
28 A Phase I Study of Cyclotron-produced Tc-99m Pertechnetate (CPERT) in Patients With Thyroid Cancer Completed NCT01437254 Phase 1 CPERT;GPERT
29 A Phase I Clinical Trial of Pazopanib in Combination With Escalating Doses of Radioactive 131I in Patients With Well-Differentiated Thyroid Carcinoma Refractory to Radioiodine, Despite Having Some Uptake Completed NCT01413113 Phase 1 pazopanib hydrochloride
30 Cognitive Functions and Mood During Thyrotropin Suppressive Therapy in Patients With Differentiated Thyroid Carcinoma Unknown status NCT02665325 TSH-suppressive therapy
31 Lacrimal Drainage System Obstruction Associated to Radioactive Iodine Therapy for Thyroid Carcinoma Unknown status NCT01579344 Radioiodine therapy
32 Clinical Evaluation of a I-124 PET/CT Based Remnant Radioiodine Ablation Decision Concept in Differentiated Thyroid Cancer Using PROBE Design Unknown status NCT01704586
33 Effectiveness of [124I]-PET/CT and [18F]-FDG-PET/CT for Localizing Recurrence in Patients With Differentiated Thyroid Carcinoma Who Have Elevated Serum Thyroglobulin Levels But Are Tumor-negative on Conventional Imaging Studies Unknown status NCT01374659
34 Brown Adipose Tissue Activity and Thyroid Hormone Completed NCT02499471
35 Clinical Evaluation of a New Highly Sensitive Thyroglobulin Assay in Differentiated Thyroid Carcinoma Completed NCT00148213
36 A Study to Evaluate and Compare the Surgical Outcomes, Aesthetic Effects and Incision Length of Different Access Procedures in Patients With DTC Completed NCT03239769
37 Is the Thyroglobulin Measurement Under Thyroxine of Prognostic Value Before rhTSH-Aided Radioiodine Ablation in Differentiated Thyroid Carcinoma? Completed NCT00439127
38 Recombinant Human TSH (rhTSH)-Aided Radioiodine (131) Therapy for Thyroid Remnant Ablation in Differentiated Thyroid Cancer Patients: a Comparison Between 1850 MBq and 3700 MBq Activities Completed NCT00454077
39 Re-differentiation of Radioiodine-Refractory BRAF V600E-mutant Papillary Thyroid Carcinoma With GSK2118436 Completed NCT01534897 GSK2118436
40 Post-Marketing Surveillance of Lenvima in Korean Patients Recruiting NCT02764554
41 Clinical Application of Continuous Monitoring Data for Biosignals by Commercially Available Wearable Devices in the Patients With Hypothyroidism Recruiting NCT04332770
42 Significance of Single Center, Open and Prospective Evaluation of Contralateral Central Lymph Node Dissection in Unilateral cN0 Differentiated Thyroid Carcinoma. Recruiting NCT03845647
43 The Role of Central Neck Dissection in Stage N0 Papillary Thyroid Carcinoma Recruiting NCT04076514
44 Relationship Between Estimated Glomerular Filtration Rate and Biological Half-life of 131I. Prospective Analysis in Patients With Differentiated Thyroid Carcinoma. Recruiting NCT02773667
45 Distinct Shifts in the Microbiota Are Associated With Iodine-131 Therapy and Hypothyroidism Recruiting NCT03574051 Early Phase 1 Probiotic
46 RIFTOS MKI - Radioactive Iodine reFractory Asymptomatic Patients in Differentiated Thyroid Cancer - an Observational Study to Assess the Use of Multikinase Inhibitors Active, not recruiting NCT02303444 Sorafenib (Nexavar, BAY43-9006);Other Multikinase inhibitors
47 Drug Use Investigation of Sorafenib/ NEXAVAR® for Unresectable Differentiated Thyroid Carcinoma (DTC) Active, not recruiting NCT02185560 Sorafenib (Nexavar, BAY43-9006)
48 Effects of Tyrosine Kinase Inhibitors on Body Composition in Endocrine Tumors -- A Pilot Study Active, not recruiting NCT02592356 Cabozantinib;Lenvatinib
49 Effect of Radioiodine Therapy on Ovarian Reserve in Female Patients With Differentiated Thyroid Cancer Not yet recruiting NCT04396158
50 Role of of F-18-fluoro-deoxy-glucose (FDG) PET/CT in Thyroid Cancer Patients With Negative I-131whole Body Scan and Elevated Thyroglobulin Level or Positive Anti Thyroglobulin Antibodies Not yet recruiting NCT04128631

Search NIH Clinical Center for Differentiated Thyroid Carcinoma

Genetic Tests for Differentiated Thyroid Carcinoma

Anatomical Context for Differentiated Thyroid Carcinoma

MalaCards organs/tissues related to Differentiated Thyroid Carcinoma:

40
Thyroid, Lymph Node, Bone, Lung, Testes, Salivary Gland, Brain

Publications for Differentiated Thyroid Carcinoma

Articles related to Differentiated Thyroid Carcinoma:

(show top 50) (show all 3172)
# Title Authors PMID Year
1
Codon-specific translation reprogramming promotes resistance to targeted therapy. 6
29925953 2018
2
A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease. 6
28854169 2017
3
eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies. 6
25079330 2014
4
Copper is required for oncogenic BRAF signalling and tumorigenesis. 6
24717435 2014
5
Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma. 6
24670642 2014
6
Germline mutations in oncogene-induced senescence pathways are associated with multiple sessile serrated adenomas. 6
24512911 2014
7
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence. 6
23685455 2013
8
Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance. 6
23302800 2013
9
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. 6
22281684 2012
10
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). 6
22113612 2011
11
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. 6
21107320 2010
12
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. 6
21107323 2010
13
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. 6
20823850 2010
14
Inhibition of mutated, activated BRAF in metastatic melanoma. 6
20818844 2010
15
BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas. 6
18398503 2008
16
Association of BRAF V600E mutation with poor clinicopathological outcomes in 500 consecutive cases of papillary thyroid carcinoma. 6
17785355 2007
17
BRAF mutations in papillary thyroid carcinomas inhibit genes involved in iodine metabolism. 6
17488796 2007
18
BRAF V600E maintains proliferation, transformation, and tumorigenicity of BRAF-mutant papillary thyroid cancer cells. 6
17374713 2007
19
Influence of the BRAF V600E mutation on expression of vascular endothelial growth factor in papillary thyroid cancer. 6
16772349 2006
20
BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer. 6
16174717 2005
21
High prevalence and possible de novo formation of BRAF mutation in metastasized papillary thyroid cancer in lymph nodes. 6
15998781 2005
22
BRAF mutations in colorectal carcinoma suggest two entities of microsatellite-unstable tumors. 6
16015629 2005
23
High incidence of thyroid cancer in long-standing goiters with thyroglobulin mutations. 6
16187918 2005
24
Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid. 6
15841082 2005
25
Silencing of the tumor suppressor gene SLC5A8 is associated with BRAF mutations in classical papillary thyroid carcinomas. 6
15687339 2005
26
Mutations of BRAF and RAS are rare events in germ cell tumours. 6
15386408 2005
27
BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing. 6
15342696 2004
28
Low frequency of BRAFT1796A mutations in childhood thyroid carcinomas. 6
15356022 2004
29
Detection of BRAF mutation on fine needle aspiration biopsy specimens: a new diagnostic tool for papillary thyroid cancer. 6
15181070 2004
30
BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas. 6
15126572 2004
31
BRAF T1796A transversion mutation in various thyroid neoplasms. 6
15001635 2004
32
Mutational analysis of BRAF and K-ras in gastric cancers: absence of BRAF mutations in gastric cancers. 6
14513361 2003
33
BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas. 6
14602780 2003
34
Exclusion of BRAFV599E as a melanoma susceptibility mutation. 6
12794760 2003
35
BRAF mutations in metastatic melanoma: a possible association with clinical outcome. 6
12960123 2003
36
High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. 6
12670889 2003
37
Absence of exon 15 BRAF germline mutations in familial melanoma. 6
12619120 2003
38
Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. 6
12644542 2003
39
High frequency of BRAF mutations in nevi. 6
12447372 2003
40
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. 6
12198537 2002
41
Mutations of the BRAF gene in human cancer. 6
12068308 2002
42
Clinical features may help to identify children and adolescents with greatest risk for thyroid nodules. 61
31927747 2020
43
Does Obesity Cause Thyroid Cancer? A Mendelian Randomization Study. 61
32392279 2020
44
The effect of iatrogenic subclinical hyperthyroidism on anxiety, depression and quality of life in differentiated thyroid carcinoma. 61
32490648 2020
45
Falsely decreased thyroglobulin levels in a patient with differentiated thyroid carcinoma. 61
32561346 2020
46
Clinical considerations for the treatment of secondary differentiated thyroid carcinoma in childhood cancer survivors. 61
32508309 2020
47
New paradigms in the treatment of low-risk thyroid cancer. 61
32511023 2020
48
Pulmonary and overall healthcare utilization after childhood and young adult thyroid cancer. 61
32252026 2020
49
TNM 8th edition in thyroid cancer staging: is there an improvement in predicting recurrence? 61
32229701 2020
50
An indirect high iodine (131 I) effective dose used for thyroid ablation in patients with thyroid cancer. Is the method of measurement important? 61
32573916 2020

Variations for Differentiated Thyroid Carcinoma

ClinVar genetic disease variations for Differentiated Thyroid Carcinoma:

6 ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 BRAF NM_001374258.1(BRAF):c.1919T>A (p.Val640Glu)SNV Pathogenic,drug response 13961 rs113488022 7:140453136-140453136 7:140753336-140753336
2 LIG4 NM_002312.3(LIG4):c.1673A>C (p.Gln558Pro)SNV Likely pathogenic 620632 rs751409106 13:108861944-108861944 13:108209596-108209596
3 CDH1 NM_004360.5(CDH1):c.2351G>C (p.Arg784Pro)SNV Uncertain significance 620631 rs763203357 16:68863612-68863612 16:68829709-68829709
4 MSH2 NM_000251.2(MSH2):c.1706A>G (p.Glu569Gly)SNV Uncertain significance 183783 rs786201077 2:47698148-47698148 2:47471009-47471009
5 PALB2 NM_024675.3(PALB2):c.2147A>G (p.Asn716Ser)SNV Uncertain significance 232654 rs148335539 16:23641328-23641328 16:23630007-23630007
6 RUNX1 NM_001754.4(RUNX1):c.749G>A (p.Arg250His)SNV Uncertain significance 239055 rs771614642 21:36206763-36206763 21:34834466-34834466

Expression for Differentiated Thyroid Carcinoma

Search GEO for disease gene expression data for Differentiated Thyroid Carcinoma.

Pathways for Differentiated Thyroid Carcinoma

Pathways related to Differentiated Thyroid Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 NTRK3 NTRK1 NRAS KRAS HRAS BRAF
2
Show member pathways
13.17 PPARG NRAS NDUFA13 KRAS HRAS BRAF
3
Show member pathways
13.08 NTRK3 NTRK1 NRAS KRAS HRAS BRAF
4
Show member pathways
13.06 NTRK3 NTRK1 NRAS KRAS HRAS ALK
5
Show member pathways
12.91 PAX8 NRAS KRAS HRAS BRAF
6
Show member pathways
12.89 PPARG NRAS KRAS HRAS BRAF
7
Show member pathways
12.89 NRAS NCOA4 KRAS HRAS BRAF
8
Show member pathways
12.88 NTRK3 NTRK1 NRAS KRAS HRAS BRAF
9
Show member pathways
12.82 NRAS KRAS HRAS EIF1AX BRAF
10 12.78 NTRK1 NRAS KRAS HRAS BRAF
11
Show member pathways
12.73 NTRK1 NRAS LPAR4 KRAS HRAS BRAF
12
Show member pathways
12.71 NTRK3 NTRK1 NRAS KRAS HRAS BRAF
13
Show member pathways
12.68 NRAS KRAS HRAS BRAF ALK
14 12.64 NRAS LPAR4 KRAS HRAS BRAF
15
Show member pathways
12.51 NRAS KRAS HRAS BRAF
16
Show member pathways
12.5 NRAS KRAS HRAS BRAF
17
Show member pathways
12.45 NTRK3 NTRK1 NRAS KRAS HRAS
18
Show member pathways
12.43 NRAS KRAS HRAS BRAF
19
Show member pathways
12.42 NRAS KRAS HRAS BRAF
20
Show member pathways
12.41 NRAS LPAR4 KRAS HRAS
21
Show member pathways
12.4 RET PPARG PAX8 NTRK1 NRAS NCOA4
22
Show member pathways
12.35 NRAS KRAS HRAS BRAF
23
Show member pathways
12.33 NRAS KRAS HRAS BRAF
24 12.32 NRAS KRAS HRAS BRAF
25
Show member pathways
12.31 NRAS KRAS HRAS BRAF
26
Show member pathways
12.29 NRAS KRAS HRAS BRAF
27
Show member pathways
12.29 PPARG NRAS KRAS HRAS BRAF
28 12.28 PPARG PAX8 NTRK1 ETV6
29
Show member pathways
12.27 NTRK3 NTRK1 NRAS KRAS HRAS BRAF
30
Show member pathways
12.21 RET NRAS KRAS HRAS
31 12.19 NDUFA13 KRAS HRAS BRAF
32
Show member pathways
12.17 NTRK3 NTRK1 NRAS KRAS HRAS BRAF
33
Show member pathways
12.15 PPARG NRAS KRAS HRAS
34
Show member pathways
12.13 PPARG NRAS KRAS HRAS BRAF
35 12.13 RET PPARG PAX8 NTRK1 NRAS NCOA4
36
Show member pathways
12.11 NRAS KRAS HRAS BRAF
37
Show member pathways
12.1 NRAS KRAS HRAS BRAF
38
Show member pathways
12.1 NRAS KRAS HRAS BRAF
39
Show member pathways
12.06 NTRK1 NRAS KRAS HRAS BRAF
40 12.02 NRAS KRAS HRAS BRAF
41 12 NRAS KRAS HRAS BRAF
42 11.98 NRAS KRAS HRAS BRAF
43
Show member pathways
11.97 NRAS KRAS HRAS BRAF
44 11.91 NRAS KRAS HRAS
45 11.89 PPARG KRAS BRAF
46
Show member pathways
11.87 NRAS KRAS HRAS
47
Show member pathways
11.86 NRAS KRAS HRAS
48 11.85 NRAS KRAS HRAS
49 11.75 NRAS KRAS HRAS BRAF
50 11.72 NRAS KRAS HRAS

GO Terms for Differentiated Thyroid Carcinoma

Cellular components related to Differentiated Thyroid Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.92 RET NTRK3 NTRK1 ALK

Biological processes related to Differentiated Thyroid Carcinoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.08 RET PPARG PAX8 NTRK3 NTRK1 ERC1
2 positive regulation of gene expression GO:0010628 9.97 RET NTRK3 KRAS HRAS BRAF
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.85 NTRK3 NTRK1 HRAS BRAF
4 positive regulation of protein phosphorylation GO:0001934 9.81 NTRK3 NTRK1 KRAS HRAS
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.78 NTRK1 KRAS ERC1 ALK
6 negative regulation of neuron apoptotic process GO:0043524 9.76 NTRK1 KRAS HRAS BRAF
7 ephrin receptor signaling pathway GO:0048013 9.75 NTRK3 NTRK1 HRAS
8 Ras protein signal transduction GO:0007265 9.73 NRAS KRAS HRAS
9 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.71 RET NTRK3 NTRK1 ALK
10 MAPK cascade GO:0000165 9.65 RET NRAS KRAS HRAS BRAF
11 positive regulation of MAPK cascade GO:0043410 9.62 RET NTRK3 NTRK1 HRAS
12 cellular response to nerve growth factor stimulus GO:1990090 9.61 NTRK3 NTRK1 BRAF
13 positive regulation of phospholipase C activity GO:0010863 9.58 NTRK3 HRAS
14 response to isolation stress GO:0035900 9.52 KRAS HRAS
15 mechanoreceptor differentiation GO:0042490 9.49 NTRK3 NTRK1
16 positive regulation of kinase activity GO:0033674 9.46 RET NTRK3 NTRK1 ALK
17 neurotrophin signaling pathway GO:0038179 9.37 NTRK3 NTRK1
18 cellular response to retinoic acid GO:0071300 9.26 RET PPARG NTRK3 NDUFA13
19 peptidyl-tyrosine phosphorylation GO:0018108 9.02 RET NTRK3 NTRK1 BRAF ALK

Molecular functions related to Differentiated Thyroid Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide binding GO:0000166 10.01 RET NTRK3 NTRK1 NRAS KRAS HRAS
2 protein kinase activity GO:0004672 9.83 RET NTRK3 NTRK1 BRAF ALK
3 GDP binding GO:0019003 9.54 NRAS KRAS HRAS
4 GPI-linked ephrin receptor activity GO:0005004 9.32 NTRK3 NTRK1
5 neurotrophin binding GO:0043121 9.26 NTRK3 NTRK1
6 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.26 RET NTRK3 NTRK1 ALK
7 neurotrophin receptor activity GO:0005030 9.16 NTRK3 NTRK1
8 protein tyrosine kinase activity GO:0004713 9.02 RET NTRK3 NTRK1 BRAF ALK

Sources for Differentiated Thyroid Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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