MCID: DFF012
MIFTS: 35

Differentiating Neuroblastoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Differentiating Neuroblastoma

MalaCards integrated aliases for Differentiating Neuroblastoma:

Name: Differentiating Neuroblastoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4160
NCIt 50 C42048
UMLS 73 C1511934

Summaries for Differentiating Neuroblastoma

MalaCards based summary : Differentiating Neuroblastoma is related to neuroblastoma and glioma. An important gene associated with Differentiating Neuroblastoma is ASCL1 (Achaete-Scute Family BHLH Transcription Factor 1), and among its related pathways/superpathways are Regulation of actin cytoskeleton and Development Dopamine D2 receptor transactivation of EGFR. The drugs Isotretinoin and Tretinoin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, testes and kidney, and related phenotypes are Decreased telomerase activity and growth/size/body region

Related Diseases for Differentiating Neuroblastoma

Diseases related to Differentiating Neuroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 neuroblastoma 10.5
2 glioma 10.0
3 neuronitis 9.8
4 alzheimer disease 9.7
5 pheochromocytoma 9.5
6 neuropathy, hereditary sensory and autonomic, type iii 9.5
7 aging 9.5
8 sarcoma 9.5
9 central neurocytoma 9.5
10 neuroendocrine tumor 9.5
11 merkel cell carcinoma 9.5
12 clear cell sarcoma 9.5
13 kidney sarcoma 9.5
14 kidney clear cell sarcoma 9.5
15 adenoma 9.5
16 mediastinitis 9.5
17 hypoglycemia 9.5
18 dysautonomia 9.5
19 hypoxia 9.5
20 peripheral nervous system disease 9.3 ELP1 SMN1
21 survival motor neuron spinal muscular atrophy 9.2 MAP1B SMN1
22 spinal muscular atrophy, type i 9.1 MAP1B SMN1

Graphical network of the top 20 diseases related to Differentiating Neuroblastoma:



Diseases related to Differentiating Neuroblastoma

Symptoms & Phenotypes for Differentiating Neuroblastoma

GenomeRNAi Phenotypes related to Differentiating Neuroblastoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased telomerase activity GR00156-A 8.8 ELP1 MAPK1 SRC

MGI Mouse Phenotypes related to Differentiating Neuroblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.91 MAPK1 NRDC ASCL1 SRC BCAR1 ELP1
2 behavior/neurological MP:0005386 9.88 MAPK1 NRDC ASCL1 SRC ELP1 MAP1B
3 mortality/aging MP:0010768 9.8 MAPK1 NRDC ASCL1 SRC BCAR1 ELP1
4 integument MP:0010771 9.72 MAPK1 ASCL1 SRC ELP1 MAP1B
5 nervous system MP:0003631 9.63 MAPK1 NRDC ASCL1 SRC ELP1 MAP1B
6 taste/olfaction MP:0005394 9.13 ASCL1 ELP1 MAPK1
7 vision/eye MP:0005391 9.02 MAPK1 ASCL1 SRC ELP1 MAP1B

Drugs & Therapeutics for Differentiating Neuroblastoma

Drugs for Differentiating Neuroblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isotretinoin Approved Phase 3 4759-48-2 5538 5282379
2
Tretinoin Approved, Investigational, Nutraceutical Phase 3 302-79-4 5538 444795

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 European Low and Intermediate Risk Neuroblastoma Protocol Recruiting NCT01728155 Phase 3 chemotherapy

Search NIH Clinical Center for Differentiating Neuroblastoma

Genetic Tests for Differentiating Neuroblastoma

Anatomical Context for Differentiating Neuroblastoma

MalaCards organs/tissues related to Differentiating Neuroblastoma:

41
Pituitary, Testes, Kidney, Brain

Publications for Differentiating Neuroblastoma

Articles related to Differentiating Neuroblastoma:

(show top 50) (show all 70)
# Title Authors Year
1
Activation of transglutaminase 2 by nerve growth factor in differentiating neuroblastoma cells: A role in cell survival and neurite outgrowth. ( 29242118 )
2018
2
Dual tumor - Clear cell sarcoma of kidney with differentiating neuroblastoma: A rare case with review of literature. ( 28195106 )
2017
3
Distinct effect of CacyBP/SIP on the ERK1/2-CREB-BDNF pathway in undifferentiated and differentiated neuroblastoma NB2a cells. ( 27180052 )
2016
4
Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells. ( 25288153 )
2015
5
Effects of IKAP/hELP1 deficiency on gene expression in differentiating neuroblastoma cells: implications for familial dysautonomia. ( 21559466 )
2011
6
The SMN protein is a key regulator of nuclear architecture in differentiating neuroblastoma cells. ( 19735367 )
2009
7
A malignant cutaneous neuroendocrine tumor with features of Merkel cell carcinoma and differentiating neuroblastoma. ( 19318809 )
2009
8
BDNF splice variants from the second promoter cluster support cell survival of differentiated neuroblastoma upon cytotoxic stress. ( 19050044 )
2009
9
Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions. ( 19726241 )
2009
10
Isoflurane attenuates dynorphin-induced cytotoxicity and downregulation of Bcl-2 expression in differentiated neuroblastoma SH-SY5Y cells. ( 19032555 )
2009
11
Proteomic analysis of differentiating neuroblastoma cells treated with sub-lethal neurite inhibitory concentrations of diazinon: identification of novel biomarkers of effect. ( 19647006 )
2009
12
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy. ( 19223552 )
2009
13
Differentiating neuroblastoma arising in mediastinal germ cell tumour. ( 18631196 )
2008
14
p53 is nuclear and functional in both undifferentiated and differentiated neuroblastoma. ( 17912039 )
2007
15
Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells. ( 17490655 )
2007
16
Resistance to geldanamycin-induced apoptosis in differentiated neuroblastoma SH-SY5Y cells. ( 17293044 )
2007
17
A "classical" homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y and pheochromocytoma PC-12 cells. ( 17045782 )
2007
18
Comparative proteomic expression profile in all-trans retinoic acid differentiated neuroblastoma cell line. ( 17559250 )
2007
19
Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways. ( 16407271 )
2006
20
The orexin OX1 receptor regulates Ca2+ entry via diacylglycerol-activated channels in differentiated neuroblastoma cells. ( 17050705 )
2006
21
Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway. ( 15548427 )
2004
22
Overexpression of alpha-synuclein decreased viability and enhanced sensitivity to prostaglandin E(2), hydrogen peroxide, and a nitric oxide donor in differentiated neuroblastoma cells. ( 15079871 )
2004
23
Cytokine action and oxidative stress response in differentiated neuroblastoma SH-SY5Y cells. ( 14515147 )
2003
24
Overexpression of amyloid precursor protein is associated with degeneration, decreased viability, and increased damage caused by neurotoxins (prostaglandins A1 and E2, hydrogen peroxide, and nitric oxide) in differentiated neuroblastoma cells. ( 13130517 )
2003
25
Arachidonate release and c-fos expression in various models of hypoxia and hypoxia-hypoglycemia in retinoic acid differentiated neuroblastoma cells. ( 11741009 )
2002
26
A functional role for ERK in gene induction, but not in neurite outgrowth in differentiating neuroblastoma cells. ( 11281640 )
2001
27
Tau proteins with frontotemporal dementia-17 mutations have both altered expression levels and phosphorylation profiles in differentiated neuroblastoma cells. ( 11738505 )
2001
28
Calcium protects differentiating neuroblastoma cells during 50 Hz electromagnetic radiation. ( 11606272 )
2001
29
Relative sensitivity of undifferentiated and cyclic adenosine 3',5'-monophosphate-induced differentiated neuroblastoma cells to cyclosporin A: potential role of beta-amyloid and ubiquitin in neurotoxicity. ( 10718363 )
2000
30
A mathematical model for assessing changes in neurofilament protein levels in neurites and cell bodies of differentiating neuroblastoma cells. ( 10873435 )
2000
31
Human achaete-scute homologue 1 (HASH-1) is downregulated in differentiating neuroblastoma cells. ( 10080936 )
1999
32
Nicardipine inhibits N-type calcium channels in dbcAMP-differentiated neuroblastoma x glioma hybrid cells (NG 108-15 cells). ( 10437156 )
1999
33
Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease. ( 9466564 )
1998
34
Prostaglandins act as neurotoxin for differentiated neuroblastoma cells in culture and increase levels of ubiquitin and beta-amyloid. ( 9557945 )
1998
35
Protein kinase C-dependent tyrosine phosphorylation of p130cas in differentiating neuroblastoma cells. ( 9442079 )
1998
36
Binding of dihydroartemisinin to differentiating neuroblastoma cells and rat cortical homogenate. ( 9621346 )
1998
37
Colocalisation of CTP:choline phosphate cytidylyltransferase (CT) with F-actin accompanies increased phosphatidylcholine synthesis in differentiating neuroblastoma cells. ( 9450022 )
1997
38
Detection of delta opioid receptor and N-methyl-D-aspartate receptor-like immunoreactivity in retinoic acid-differentiated neuroblastoma x glioma (NG108-15) cells. ( 8981241 )
1997
39
Fluorescent differential display analysis of gene expression in differentiating neuroblastoma cells. ( 9016955 )
1997
40
Size changes in differentiating neuroblastoma cells. ( 9466674 )
1997
41
Vitronectin expression in differentiating neuroblastic tumors: integrin alpha v beta 5 mediates vitronectin-dependent adhesion of retinoic-acid-differentiated neuroblastoma cells. ( 9137089 )
1997
42
Nimodipine and nitrendipine inhibit N-type calcium channels in dibutyryl cAMP-differentiated neuroblastoma x glioma hybrid (NG 108-15) cells. ( 9259470 )
1997
43
Production and function of lipid second messengers in proliferating and differentiated neuroblastoma cells. ( 8906581 )
1996
44
Effect of culture age on the susceptibility of differentiating neuroblastoma cells to retinoid cytotoxicity. ( 18627021 )
1996
45
The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells. ( 8657106 )
1996
46
Differentiating neuroblastoma of pituitary gland: neuroblastic transformation of epithelial adenoma cells. Case report. ( 8893739 )
1996
47
Biochemical evidence for a mature phenotype in morphologically poorly differentiated neuroblastomas with a favourable outcome. ( 7576941 )
1995
48
Functional expression of human D3 dopamine receptors in differentiated neuroblastoma x glioma NG108-15 cells. ( 7911712 )
1994
49
Two distinct ATP signaling mechanisms in differentiated neuroblastoma x glioma hybrid NG108-15 cells. ( 7511780 )
1994
50
Induction of apoptotic cell death in differentiating neuroblastoma SH-SY5Y cells by colchicine. ( 8135827 )
1994

Variations for Differentiating Neuroblastoma

Expression for Differentiating Neuroblastoma

Search GEO for disease gene expression data for Differentiating Neuroblastoma.

Pathways for Differentiating Neuroblastoma

Pathways related to Differentiating Neuroblastoma according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1 12.39 BCAR1 MAPK1 SRC
2
Show member pathways
12.34 BCAR1 MAPK1 SRC
3
Show member pathways
12.18 BCAR1 MAPK1 SRC
4
Show member pathways
11.91 BCAR1 MAPK1 SRC
5 11.87 BCAR1 MAPK1 SRC
6 11.67 BCAR1 MAPK1 SRC
7 11.48 BCAR1 SRC
8
Show member pathways
11.48 MAPK1 SRC
9 11.47 MAPK1 SRC
10 11.4 MAPK1 SRC
11 11.38 BCAR1 SRC
12 11.34 BCAR1 SRC
13 11.31 MAPK1 SRC
14 11.29 MAPK1 SRC
15 11.29 MAPK1 SRC
16 11.26 MAPK1 SRC
17
Show member pathways
11.26 BCAR1 MAPK1
18 11.24 MAPK1 SRC
19
Show member pathways
11.23 BCAR1 SRC
20 11.23 BCAR1 MAPK1 SRC
21 11.16 BCAR1 MAPK1 SRC
22
Show member pathways
11.14 MAPK1 SRC
23 11.11 MAPK1 SRC
24 11.09 MAPK1 SRC
25 11.06 MAPK1 SRC
26 10.99 BCAR1 MAPK1 SRC
27 10.98 MAPK1 SRC
28 10.95 BCAR1 SRC
29 10.92 MAPK1 SRC
30 10.89 MAPK1 SRC
31 10.86 MAPK1 SRC
32 10.71 MAPK1 SRC
33 10.71 BCAR1 MAPK1 SRC
34 10.63 BCAR1 SRC
35 10.16 BCAR1 MAPK1 SRC

GO Terms for Differentiating Neuroblastoma

Cellular components related to Differentiating Neuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.17 BCAR1 ELP1 MAP1B MAPK1 NRDC SMN1

Biological processes related to Differentiating Neuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell migration GO:0016477 9.5 BCAR1 NRDC SRC
2 epidermal growth factor receptor signaling pathway GO:0007173 9.43 BCAR1 SRC
3 positive regulation of cell migration GO:0030335 9.43 BCAR1 ELP1 MAPK1
4 cellular response to reactive oxygen species GO:0034614 9.4 MAPK1 SRC
5 platelet-derived growth factor receptor signaling pathway GO:0048008 9.37 BCAR1 SRC
6 neurotrophin TRK receptor signaling pathway GO:0048011 9.16 BCAR1 SRC
7 regulation of early endosome to late endosome transport GO:2000641 8.96 MAPK1 SRC
8 response to epidermal growth factor GO:0070849 8.62 ASCL1 MAPK1

Sources for Differentiating Neuroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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