MCID: DFF012
MIFTS: 35

Differentiating Neuroblastoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Differentiating Neuroblastoma

MalaCards integrated aliases for Differentiating Neuroblastoma:

Name: Differentiating Neuroblastoma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4160
NCIt 51 C42048
UMLS 74 C1511934

Summaries for Differentiating Neuroblastoma

MalaCards based summary : Differentiating Neuroblastoma is related to neuroblastoma 1 and glioma. An important gene associated with Differentiating Neuroblastoma is ASCL1 (Achaete-Scute Family BHLH Transcription Factor 1), and among its related pathways/superpathways are Regulation of actin cytoskeleton and Development Dopamine D2 receptor transactivation of EGFR. The drugs Isotretinoin and Tretinoin have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and testes, and related phenotypes are Decreased telomerase activity and behavior/neurological

Related Diseases for Differentiating Neuroblastoma

Diseases related to Differentiating Neuroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)
# Related Disease Score Top Affiliating Genes
1 neuroblastoma 1 10.1
2 glioma 10.1
3 alzheimer disease 9.8
4 pheochromocytoma 9.7
5 wilms tumor 1 9.7
6 neuropathy, hereditary sensory and autonomic, type iii 9.7
7 frontotemporal dementia 9.7
8 wilms tumor 5 9.7
9 wilms tumor 6 9.7
10 adrenal gland pheochromocytoma 9.7
11 sarcoma 9.7
12 dementia 9.7
13 central neurocytoma 9.7
14 neuroendocrine tumor 9.7
15 merkel cell carcinoma 9.7
16 clear cell sarcoma 9.7
17 spindle cell sarcoma 9.7
18 kidney sarcoma 9.7
19 kidney clear cell sarcoma 9.7
20 adenoma 9.7
21 chickenpox 9.7
22 hypoglycemia 9.7
23 hypoxia 9.7
24 dysautonomia 9.7
25 survival motor neuron spinal muscular atrophy 9.6 MAP1B SMN1
26 spinal muscular atrophy, type i 9.5 MAP1B SMN1

Graphical network of the top 20 diseases related to Differentiating Neuroblastoma:



Diseases related to Differentiating Neuroblastoma

Symptoms & Phenotypes for Differentiating Neuroblastoma

GenomeRNAi Phenotypes related to Differentiating Neuroblastoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased telomerase activity GR00156-A 8.8 ELP1 MAPK1 SRC

MGI Mouse Phenotypes related to Differentiating Neuroblastoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 ASCL1 ELP1 MAP1B MAPK1 NRDC SRC
2 growth/size/body region MP:0005378 9.91 ASCL1 BCAR1 ELP1 MAP1B MAPK1 NRDC
3 cellular MP:0005384 9.88 ASCL1 BCAR1 ELP1 MAP1B MAPK1 SRC
4 mortality/aging MP:0010768 9.8 ASCL1 BCAR1 ELP1 MAP1B MAPK1 NRDC
5 integument MP:0010771 9.72 ASCL1 ELP1 MAP1B MAPK1 SRC
6 nervous system MP:0003631 9.63 ASCL1 ELP1 MAP1B MAPK1 NRDC SRC
7 taste/olfaction MP:0005394 9.13 ASCL1 ELP1 MAPK1
8 vision/eye MP:0005391 9.02 ASCL1 ELP1 MAP1B MAPK1 SRC

Drugs & Therapeutics for Differentiating Neuroblastoma

Drugs for Differentiating Neuroblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isotretinoin Approved Phase 3 4759-48-2 5282379 5538
2
Tretinoin Approved, Investigational, Nutraceutical Phase 3 302-79-4 444795 5538

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 European Low and Intermediate Risk Neuroblastoma Protocol Recruiting NCT01728155 Phase 3 chemotherapy

Search NIH Clinical Center for Differentiating Neuroblastoma

Genetic Tests for Differentiating Neuroblastoma

Anatomical Context for Differentiating Neuroblastoma

MalaCards organs/tissues related to Differentiating Neuroblastoma:

42
Kidney, Brain, Testes, Pituitary, Adrenal Gland

Publications for Differentiating Neuroblastoma

Articles related to Differentiating Neuroblastoma:

(show all 41)
# Title Authors Year
1
Activation of transglutaminase 2 by nerve growth factor in differentiating neuroblastoma cells: A role in cell survival and neurite outgrowth. ( 29242118 )
2018
2
Dual tumor - Clear cell sarcoma of kidney with differentiating neuroblastoma: A rare case with review of literature. ( 28195106 )
2017
3
Effects of IKAP/hELP1 deficiency on gene expression in differentiating neuroblastoma cells: implications for familial dysautonomia. ( 21559466 )
2011
4
A malignant cutaneous neuroendocrine tumor with features of Merkel cell carcinoma and differentiating neuroblastoma. ( 19318809 )
2009
5
Proteomic analysis of differentiating neuroblastoma cells treated with sub-lethal neurite inhibitory concentrations of diazinon: identification of novel biomarkers of effect. ( 19647006 )
2009
6
The SMN protein is a key regulator of nuclear architecture in differentiating neuroblastoma cells. ( 19735367 )
2009
7
Differentiating neuroblastoma arising in mediastinal germ cell tumour. ( 18631196 )
2008
8
Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells. ( 17490655 )
2007
9
Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway. ( 15548427 )
2004
10
A functional role for ERK in gene induction, but not in neurite outgrowth in differentiating neuroblastoma cells. ( 11281640 )
2001
11
Calcium protects differentiating neuroblastoma cells during 50 Hz electromagnetic radiation. ( 11606272 )
2001
12
A mathematical model for assessing changes in neurofilament protein levels in neurites and cell bodies of differentiating neuroblastoma cells. ( 10873435 )
2000
13
Human achaete-scute homologue 1 (HASH-1) is downregulated in differentiating neuroblastoma cells. ( 10080936 )
1999
14
Protein kinase C-dependent tyrosine phosphorylation of p130cas in differentiating neuroblastoma cells. ( 9442079 )
1998
15
Binding of dihydroartemisinin to differentiating neuroblastoma cells and rat cortical homogenate. ( 9621346 )
1998
16
Fluorescent differential display analysis of gene expression in differentiating neuroblastoma cells. ( 9016955 )
1997
17
Colocalisation of CTP:choline phosphate cytidylyltransferase (CT) with F-actin accompanies increased phosphatidylcholine synthesis in differentiating neuroblastoma cells. ( 9450022 )
1997
18
Size changes in differentiating neuroblastoma cells. ( 9466674 )
1997
19
The cyclin-dependent kinase inhibitor p21 (WAF1) is required for survival of differentiating neuroblastoma cells. ( 8657106 )
1996
20
Differentiating neuroblastoma of pituitary gland: neuroblastic transformation of epithelial adenoma cells. Case report. ( 8893739 )
1996
21
Effect of culture age on the susceptibility of differentiating neuroblastoma cells to retinoid cytotoxicity. ( 18627021 )
1996
22
Induction of apoptotic cell death in differentiating neuroblastoma SH-SY5Y cells by colchicine. ( 8135827 )
1994
23
Temporal expression of neurofilament polypeptides in differentiating neuroblastoma cells. ( 1662992 )
1991
24
Retinoic acid and alpha-difluoromethylornithine induce different expression of neural-specific cell adhesion molecules in differentiating neuroblastoma cells. ( 2068145 )
1991
25
A lead-associated nuclear protein which increases in maturing brain and in differentiating neuroblastoma 2A cells exposed to cyclic AMP-elevating agents. ( 1708708 )
1990
26
Cyclic AMP-dependent expression of the heavy neurofilament (NF-H) polypeptide in differentiating neuroblastoma cells. ( 2160043 )
1990
27
Surface glycoproteins of differentiating neuroblastoma cells analyzed by lectin binding and flow cytometry. ( 3665675 )
1987
28
A short-term screening test for teratogens using differentiating neuroblastoma cells in vitro. ( 6740511 )
1984
29
Modulation in the levels and localization of plasminogen activator in differentiating neuroblastoma cells. ( 6133597 )
1983
30
Ultrastructural changes in differentiating neuroblastoma x glioma hybrid cells. ( 6320493 )
1983
31
DNA synthesis in differentiating neuroblastoma cells following induction by glioma cells. ( 7083276 )
1982
32
Tubulin pools in differentiating neuroblastoma cells. ( 7251659 )
1981
33
Acyltransferase activity and cytochemical localization in differentiating neuroblastoma. ( 7307080 )
1981
34
Lateral diffusion of membrane D-galactosyl glycoconjugates of differentiating neuroblastoma cells. ( 7332554 )
1981
35
Complexity of polysomal poly(A)RNA in different developmental stages of a non-differentiating neuroblastoma clone. ( 7215538 )
1980
36
A pigmented differentiating neuroblastoma: a light and ultrastructural study. ( 7397624 )
1980
37
Lateral diffusion of membrane lipids and proteins is increased specifically in neurites of differentiating neuroblastoma cells. ( 508746 )
1979
38
Specific alterations in phosphorylation of cytosol proteins from differentiating neuroblastoma cells grown in culture. ( 189207 )
1977
39
Increased rate of acetylcholinesterase synthesis in differentiating neuroblastoma cells. ( 4548065 )
1974
40
Rates of oxygen uptake in proliferating and differentiating neuroblastoma cells. ( 5025651 )
1972
41
A differentiating neuroblastoma. ( 5843953 )
1965

Variations for Differentiating Neuroblastoma

Expression for Differentiating Neuroblastoma

Search GEO for disease gene expression data for Differentiating Neuroblastoma.

Pathways for Differentiating Neuroblastoma

Pathways related to Differentiating Neuroblastoma according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1 12.39 BCAR1 MAPK1 SRC
2
Show member pathways
12.33 BCAR1 MAPK1 SRC
3
Show member pathways
12.16 BCAR1 MAPK1 SRC
4 11.85 BCAR1 MAPK1 SRC
5 11.67 BCAR1 MAPK1 SRC
6 11.49 MAPK1 SRC
7 11.48 BCAR1 SRC
8
Show member pathways
11.47 MAPK1 SRC
9 11.47 MAPK1 SRC
10 11.4 MAPK1 SRC
11 11.37 BCAR1 SRC
12 11.33 BCAR1 SRC
13 11.32 MAPK1 SRC
14 11.31 MAPK1 SRC
15 11.29 MAPK1 SRC
16 11.29 MAPK1 SRC
17 11.26 MAPK1 SRC
18
Show member pathways
11.25 BCAR1 MAPK1
19 11.23 MAPK1 SRC
20
Show member pathways
11.23 BCAR1 SRC
21 11.23 BCAR1 MAPK1 SRC
22 11.16 BCAR1 MAPK1 SRC
23
Show member pathways
11.13 MAPK1 SRC
24 11.1 MAPK1 SRC
25 11.08 MAPK1 SRC
26 11.05 MAPK1 SRC
27 10.99 BCAR1 MAPK1 SRC
28 10.97 MAPK1 SRC
29 10.94 BCAR1 SRC
30 10.91 MAPK1 SRC
31 10.87 MAPK1 SRC
32 10.84 MAPK1 SRC
33 10.71 BCAR1 MAPK1 SRC
34 10.69 MAPK1 SRC
35 10.63 BCAR1 SRC
36 10.16 BCAR1 MAPK1 SRC

GO Terms for Differentiating Neuroblastoma

Cellular components related to Differentiating Neuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.5 BCAR1 ELP1 MAP1B MAPK1 NRDC SMN1
2 postsynaptic density GO:0014069 8.8 MAP1B MAPK1 SRC

Biological processes related to Differentiating Neuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.63 BCAR1 NRDC SRC
2 positive regulation of cell migration GO:0030335 9.5 BCAR1 ELP1 MAPK1
3 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.43 BCAR1 SRC
4 cell migration GO:0016477 9.43 BCAR1 NRDC SRC
5 epidermal growth factor receptor signaling pathway GO:0007173 9.4 BCAR1 SRC
6 cellular response to reactive oxygen species GO:0034614 9.37 MAPK1 SRC
7 neurotrophin TRK receptor signaling pathway GO:0048011 9.16 BCAR1 SRC
8 regulation of early endosome to late endosome transport GO:2000641 8.96 MAPK1 SRC
9 response to epidermal growth factor GO:0070849 8.62 ASCL1 MAPK1

Sources for Differentiating Neuroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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