MCID: DFF012
MIFTS: 28

Differentiating Neuroblastoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Differentiating Neuroblastoma

MalaCards integrated aliases for Differentiating Neuroblastoma:

Name: Differentiating Neuroblastoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4160
NCIt 49 C42048
UMLS 71 C1511934

Summaries for Differentiating Neuroblastoma

MalaCards based summary : Differentiating Neuroblastoma is related to neuroblastoma and neuropathy, hereditary sensory and autonomic, type iii. An important gene associated with Differentiating Neuroblastoma is ASCL1 (Achaete-Scute Family BHLH Transcription Factor 1), and among its related pathways/superpathways are Signaling events regulated by Ret tyrosine kinase and Signaling events mediated by PRL. Affiliated tissues include bone, brain and kidney, and related phenotypes are cellular and taste/olfaction

Related Diseases for Differentiating Neuroblastoma

Diseases related to Differentiating Neuroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 neuroblastoma 29.4 MYCNUT MYCN MAPK1 LINC01587 CYTH2 ASCL1
2 neuropathy, hereditary sensory and autonomic, type iii 29.0 SMN1 ELP1 ASCL1
3 glioma 10.2
4 glial tumor 10.2
5 alzheimer disease 10.0
6 ganglioneuroma 9.9
7 ischemic neuropathy 9.8 POU4F2 COIL
8 pertussis 9.8
9 oligodendroglioma 9.8
10 ganglioneuroblastoma 9.8
11 amyotrophic lateral sclerosis 1 9.6
12 hypercholesterolemia, familial, 1 9.6
13 pheochromocytoma 9.6
14 wilms tumor 1 9.6
15 galactorrhea 9.6
16 insulin-like growth factor i 9.6
17 frontotemporal dementia 9.6
18 wilms tumor 5 9.6
19 leukemia, acute lymphoblastic 3 9.6
20 hyperprolactinemia 9.6
21 adrenal gland pheochromocytoma 9.6
22 spinal muscular atrophy 9.6
23 amenorrhea 9.6
24 central neurocytoma 9.6
25 neuroendocrine tumor 9.6
26 neuroendocrine carcinoma 9.6
27 lateral sclerosis 9.6
28 gangliocytoma 9.6
29 astrocytoma 9.6
30 rhabdomyosarcoma 9.6
31 embryonal carcinoma 9.6
32 pituitary adenoma 9.6
33 merkel cell carcinoma 9.6
34 cerebral neuroblastoma 9.6
35 clear cell sarcoma 9.6
36 kidney sarcoma 9.6
37 benign ependymoma 9.6
38 kidney clear cell sarcoma 9.6
39 infertility 9.6
40 cellular ependymoma 9.6
41 adenoma 9.6
42 muscular atrophy 9.6
43 herpes simplex 9.6
44 chickenpox 9.6
45 hypoglycemia 9.6
46 48,xyyy 9.6
47 cytokine deficiency 9.6
48 dysautonomia 9.6
49 hypoxia 9.6
50 rapidly involuting congenital hemangioma 9.6

Graphical network of the top 20 diseases related to Differentiating Neuroblastoma:



Diseases related to Differentiating Neuroblastoma

Symptoms & Phenotypes for Differentiating Neuroblastoma

MGI Mouse Phenotypes related to Differentiating Neuroblastoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.61 ASCL1 BCAR1 COIL ELP1 MAP1B MAPK1
2 taste/olfaction MP:0005394 8.8 ASCL1 ELP1 MAPK1

Drugs & Therapeutics for Differentiating Neuroblastoma

Search Clinical Trials , NIH Clinical Center for Differentiating Neuroblastoma

Genetic Tests for Differentiating Neuroblastoma

Anatomical Context for Differentiating Neuroblastoma

MalaCards organs/tissues related to Differentiating Neuroblastoma:

40
Bone, Brain, Kidney, Testes, Dorsal Root Ganglion, Pituitary

Publications for Differentiating Neuroblastoma

Articles related to Differentiating Neuroblastoma:

(show top 50) (show all 93)
# Title Authors PMID Year
1
Pediatric neuroblastic tumors: A critical evaluation of cytomorphological features for risk stratification on aspiration cytology. 61
32043835 2020
2
Cells with ganglionic differentiation frequently stain for VE1 antibody: a potential pitfall. 61
31820133 2020
3
SOX-11 regulates LINE-1 retrotransposon activity during neuronal differentiation. 61
30276805 2018
4
Activation of transglutaminase 2 by nerve growth factor in differentiating neuroblastoma cells: A role in cell survival and neurite outgrowth. 61
29242118 2018
5
Secretome analysis to elucidate metalloprotease-dependent ectodomain shedding of glycoproteins during neuronal differentiation. 61
28084684 2017
6
CDDO and ATRA Instigate Differentiation of IMR32 Human Neuroblastoma Cells. 61
29018329 2017
7
Dual tumor - Clear cell sarcoma of kidney with differentiating neuroblastoma: A rare case with review of literature. 61
28195106 2017
8
Simultaneous quantification of actin monomer and filament dynamics with modeling-assisted analysis of photoactivation. 61
27831495 2016
9
Oncologic Phenotype of Peripheral Neuroblastic Tumors Associated With PHOX2B Non-Polyalanine Repeat Expansion Mutations. 61
26375764 2016
10
Uridine from Pleurotus giganteus and Its Neurite Outgrowth Stimulatory Effects with Underlying Mechanism. 61
26565787 2015
11
Proteolytic control of neurite outgrowth inhibitor NOGO-A by the cAMP/PKA pathway. 61
25331889 2014
12
MYCN gene expression is required for the onset of the differentiation programme in neuroblastoma cells. 61
24556696 2014
13
Primary subconjunctival ganglioneuroma. 61
23034687 2013
14
APC/C (Cdh1) controls the proteasome-mediated degradation of E2F3 during cell cycle exit. 61
22580460 2012
15
Smear preparation of intracranial lesions: a retrospective study of 306 cases. 61
21761576 2011
16
Effects of IKAP/hELP1 deficiency on gene expression in differentiating neuroblastoma cells: implications for familial dysautonomia. 61
21559466 2011
17
The beta isotypes of tubulin in neuronal differentiation. 61
20506160 2010
18
Microtubule-associated protein-2 is a sensitive marker of primary and metastatic neuroblastoma. 61
19701075 2009
19
Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways. 61
19801649 2009
20
The SMN protein is a key regulator of nuclear architecture in differentiating neuroblastoma cells. 61
19735367 2009
21
Proteomic analysis of differentiating neuroblastoma cells treated with sub-lethal neurite inhibitory concentrations of diazinon: identification of novel biomarkers of effect. 61
19647006 2009
22
A malignant cutaneous neuroendocrine tumor with features of Merkel cell carcinoma and differentiating neuroblastoma. 61
19318809 2009
23
Mesenchymal stem cells expressing neural antigens instruct a neurogenic cell fate on neural stem cells. 61
19159625 2009
24
Differentiating neuroblastoma arising in mediastinal germ cell tumour. 61
18631196 2008
25
Neuroblastoma and opsoclonus-myoclonus-ataxia syndrome--clinical and pathological characteristics. 61
18825593 2008
26
p53 is nuclear and functional in both undifferentiated and differentiated neuroblastoma. 61
17912039 2007
27
The transcription factor Runx3 represses the neurotrophin receptor TrkB during lineage commitment of dorsal root ganglion neurons. 61
17584746 2007
28
Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells. 61
17490655 2007
29
Metanephric neoplasms: the hyperdifferentiated, benign end of the Wilms tumor spectrum? 61
15848742 2005
30
Expression of the repressor element-1 silencing transcription factor (REST) is influenced by insulin-like growth factor-I in differentiating human neuroblastoma cells. 61
15654842 2005
31
Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway. 61
15548427 2004
32
Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. 61
11756408 2002
33
Maturation of mass-screened localized adrenal neuroblastoma. 61
11685689 2001
34
Calcium protects differentiating neuroblastoma cells during 50 Hz electromagnetic radiation. 61
11606272 2001
35
Neuroblastic and Schwannian stromal cells of neuroblastoma are derived from a tumoral progenitor cell. 61
11559566 2001
36
Discovery of a novel compound: insight into mechanisms for acrylamide-induced axonopathy and colchicine-induced apoptotic neuronal cell death. 61
11478917 2001
37
p53 cellular localization and function in neuroblastoma: evidence for defective G(1) arrest despite WAF1 induction in MYCN-amplified cells. 61
11395384 2001
38
Metabolic activity and clinical features of primary ganglioneuromas. 61
11346873 2001
39
A functional role for ERK in gene induction, but not in neurite outgrowth in differentiating neuroblastoma cells. 61
11281640 2001
40
Induced neuroblastoma cell differentiation, associated with transient HES-1 activity and reduced HASH-1 expression, is inhibited by Notch1. 61
11054669 2000
41
A mathematical model for assessing changes in neurofilament protein levels in neurites and cell bodies of differentiating neuroblastoma cells. 61
10873435 2000
42
Use of tumor-specific gene expression for the differential diagnosis of neuroblastoma from other pediatric small round-cell malignancies. 61
10393831 1999
43
Developmental appearance of nuclear GM1 in neurons of the central and peripheral nervous systems. 61
10407137 1999
44
Human achaete-scute homologue 1 (HASH-1) is downregulated in differentiating neuroblastoma cells. 61
10080936 1999
45
Cholinesterases in neural development: new findings and toxicologic implications. 61
10229707 1999
46
Upregulation of ecto-5'-nucleotidase in human neuroblastoma SH-SY5Y cells on differentiation by retinoic acid or phorbolester. 61
9885947 1998
47
Binding of dihydroartemisinin to differentiating neuroblastoma cells and rat cortical homogenate. 61
9621346 1998
48
Protein kinase C-dependent tyrosine phosphorylation of p130cas in differentiating neuroblastoma cells. 61
9442079 1998
49
Size changes in differentiating neuroblastoma cells. 61
9466674 1997
50
Colocalisation of CTP:choline phosphate cytidylyltransferase (CT) with F-actin accompanies increased phosphatidylcholine synthesis in differentiating neuroblastoma cells. 61
9450022 1997

Variations for Differentiating Neuroblastoma

Expression for Differentiating Neuroblastoma

Search GEO for disease gene expression data for Differentiating Neuroblastoma.

Pathways for Differentiating Neuroblastoma

Pathways related to Differentiating Neuroblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.54 MAPK1 BCAR1
2 9.98 MAPK1 BCAR1

GO Terms for Differentiating Neuroblastoma

Cellular components related to Differentiating Neuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perikaryon GO:0043204 9.33 SMN1 MAPK1 MAP1B
2 growth cone GO:0030426 9.13 MAP1B CYTH2 CCDC120
3 axon GO:0030424 9.02 SMN1 PALM MAPK1 MAP1B BCAR1

Biological processes related to Differentiating Neuroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of axon extension GO:0045773 9.46 POU4F2 MAP1B
2 positive regulation of neurogenesis GO:0050769 9.43 NUMBL ASCL1
3 spliceosomal snRNP assembly GO:0000387 9.4 SMN1 COIL
4 regulation of DNA-binding transcription factor activity GO:0051090 9.37 POU4F2 MAPK1
5 nervous system development GO:0007399 9.35 SMN1 NUMBL MAP1B LINC01587 ASCL1
6 axonogenesis GO:0007409 9.33 POU4F2 NUMBL MAP1B
7 axon extension GO:0048675 9.32 POU4F2 MAP1B
8 neuroblast proliferation GO:0007405 9.26 NUMBL ASCL1
9 response to epidermal growth factor GO:0070849 8.62 MAPK1 ASCL1

Sources for Differentiating Neuroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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