MCID: DFF010
MIFTS: 25

Diffuse Alopecia Areata

Categories: Immune diseases

Aliases & Classifications for Diffuse Alopecia Areata

MalaCards integrated aliases for Diffuse Alopecia Areata:

Name: Diffuse Alopecia Areata 12 15 71
Diffuse Alopecia 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0060157
MeSH 43 C531609
UMLS 71 C0263479 C0406458 C1274706 more

Summaries for Diffuse Alopecia Areata

Disease Ontology : 12 An alopecia areata that involves diffuse loss of hair over the whole scalp.

MalaCards based summary : Diffuse Alopecia Areata, also known as diffuse alopecia, is related to telogen effluvium and palmoplantar keratoderma, mutilating, with periorificial keratotic plaques, x-linked. An important gene associated with Diffuse Alopecia Areata is SLITRK1 (SLIT And NTRK Like Family Member 1). Affiliated tissues include thyroid, skin and lung.

Related Diseases for Diffuse Alopecia Areata

Diseases related to Diffuse Alopecia Areata via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 telogen effluvium 29.7 SLITRK1 EDA2R
2 palmoplantar keratoderma, mutilating, with periorificial keratotic plaques, x-linked 11.4
3 palmoplantar keratoderma, mutilating, with periorificial keratotic plaques 11.4
4 epidermolysis bullosa simplex, generalized, with scarring and hair loss 11.2
5 alopecia areata 10.6
6 alopecia 10.6
7 alopecia, androgenetic, 1 10.2
8 androgenic alopecia 10.2
9 vitiligo-associated multiple autoimmune disease susceptibility 6 10.0
10 alopecia universalis congenita 10.0
11 myasthenia gravis 10.0
12 vitiligo-associated multiple autoimmune disease susceptibility 1 10.0
13 graft-versus-host disease 10.0
14 hair disease 10.0
15 folliculitis 10.0
16 pemphigus 10.0
17 hypereosinophilic syndrome 10.0
18 alopecia totalis 10.0
19 lipedematous scalp 10.0
20 pemphigus foliaceus 10.0
21 discoid lupus erythematosus 10.0
22 syphilis 10.0
23 epidermolysis bullosa simplex with muscular dystrophy 9.9
24 epidermolysis bullosa 9.9
25 secondary syphilis 9.9
26 pustulosis of palm and sole 9.9
27 epidermolysis bullosa simplex 9.9
28 crohn's disease 9.9
29 psoriasis 9.9
30 amyloidosis 9.9
31 muscular dystrophy 9.9
32 al amyloidosis 9.9
33 hashimoto thyroiditis 9.8
34 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 9.8
35 immune deficiency disease 9.8
36 leprosy 3 9.8
37 hyperprolactinemia 9.8
38 deficiency anemia 9.8
39 exanthem 9.8
40 early congenital syphilis 9.8
41 autosomal recessive disease 9.8
42 hypogonadotropic hypogonadism 9.8
43 lymphocytic leukemia 9.8
44 lepromatous leprosy 9.8
45 ovarian disease 9.8
46 anhidrosis 9.8
47 primary hyperparathyroidism 9.8
48 hyperandrogenism 9.8
49 iron deficiency anemia 9.8
50 hyperparathyroidism 9.8

Graphical network of the top 20 diseases related to Diffuse Alopecia Areata:



Diseases related to Diffuse Alopecia Areata

Symptoms & Phenotypes for Diffuse Alopecia Areata

Drugs & Therapeutics for Diffuse Alopecia Areata

Search Clinical Trials , NIH Clinical Center for Diffuse Alopecia Areata

Cochrane evidence based reviews: diffuse alopecia

Genetic Tests for Diffuse Alopecia Areata

Anatomical Context for Diffuse Alopecia Areata

MalaCards organs/tissues related to Diffuse Alopecia Areata:

40
Thyroid, Skin, Lung, Bone, T Cells, Bone Marrow, Cortex

Publications for Diffuse Alopecia Areata

Articles related to Diffuse Alopecia Areata:

(show top 50) (show all 225)
# Title Authors PMID Year
1
Rare manifestation of hypereosinophilic syndrome: Diffuse-type hair loss with massive perifollicular eosinophils. 61
31713896 2020
2
Nonscarring alopecia in systemic lupus erythematosus: A cross-sectional study with trichoscopic, histopathologic, and immunopathologic analyses. 61
31150712 2019
3
Diffuse Alopecia Areata Associated with Weight-Loss Pills. 61
32030057 2019
4
Alopecia Areata Incognita and Diffuse Alopecia Areata: Clinical, Trichoscopic, Histopathological, and Therapeutic Features of a 5-Year Study. 61
31723460 2019
5
[Alopecia, deformed ear and mental retardation associated with terminal 21q deletion]. 61
30922549 2019
6
2-deoxy D-glucose treatment does not elicit a hair growth response in alopecia areata. 61
31323149 2019
7
Distinguishing Lipedematous Scalp, Lipedematous Alopecia, and Diffuse Alopecia Areata. 61
31559257 2019
8
Pathogenesis and clinical features of alopecia in epidermolysis bullosa: A systematic review. 61
31177584 2019
9
Assessment of Quality of Life and Treatment Outcomes of Patients With Persistent Postchemotherapy Alopecia. 61
30840033 2019
10
Linagliptin-Associated Alopecia and Bullous Pemphigoid. 61
31583211 2019
11
Debilitating disease in a polyparasitised woylie (Bettongia penicillata): A diagnostic investigation. 61
30094176 2018
12
Sequential cyclic changes of hair roots revealed by dermoscopy demonstrate a progressive mechanism of diffuse alopecia areata over time. 61
30307062 2018
13
Nonspecific diffuse alopecia as a single manifestation of syphilis infection: clinical and trichoscopic features. 61
29336022 2018
14
A novel PLEC nonsense homozygous mutation (c.7159G > T; p.Glu2387*) causes epidermolysis bullosa simplex with muscular dystrophy and diffuse alopecia: a case report. 61
29352809 2018
15
Hair Loss: Evidence to Thallium Poisoning. 61
30046496 2018
16
Toxic epidermal necrolysis in a female with metastatic breast cancer treated with vinorelbine. 61
29983677 2017
17
Unsuccessful Treatment of Alopecia Areata with Simvastatin/Ezetimibe: Experience in 12 Patients. 61
28879192 2017
18
Permanent diffuse alopecia after haematopoietic stem cell transplantation in childhood. 61
28319079 2017
19
Laryngeal Neuropathy in Adult Goats With Copper Deficiency. 61
28622494 2017
20
Value of dermoscopy for the diagnosis of monilethrix. 61
29469711 2017
21
Late-onset robust curly hair growth in a patient with BRAF-mutated metastatic melanoma responding to dabrafenib. 61
26946529 2017
22
[Psoriasis capitis and seborrhoic eczema of scalp diseases]. 61
28567508 2017
23
Lithium: one drug, five complications. 61
29276608 2017
24
Acute Alopecia: Evidence to Thallium Poisoning. 61
28761262 2017
25
Presence of Mast Cells and Mast Cell Degranulation in Scalp Biopsies of Telogen Effluvium. 61
28761261 2017
26
Morphological variability of Demodex cati in a feline immunodeficiency virus-positive cat. 61
27875092 2016
27
Acrodermatitis enteropathica in a pair of twins. 61
28435477 2016
28
Severe Infliximab-Induced Alopecia and Scalp Psoriasis in a Woman with Crohn's Disease: Dramatic Improvement after Drug Discontinuation and Treatment with Adjuvant Systemic and Topical Therapies. 61
27844446 2016
29
[What is new in basal cell carcinoma?] 61
27654826 2016
30
Loose Anchoring of Anagen Hairs and Pili Torti due to Erlotinib. 61
28442878 2016
31
Halo naevi, vitiligo and diffuse alopecia areata associated with tocilizumab therapy. 61
27516894 2016
32
Two familial cases of Olmsted-like syndrome with a G573V mutation of the TRPV3 gene. 61
27273692 2016
33
Distinguishing diffuse alopecia areata (AA) from pattern hair loss (PHL) using CD3(+) T cells. 61
26851831 2016
34
Trichodynia: a review of the literature. 61
26696219 2016
35
Phrynoderma and acquired acrodermatitis enteropathica in breastfeeding women after bariatric surgery. 61
26513075 2015
36
[Drug treatment of alopecia]. 61
26383761 2015
37
Female Pattern Hair Loss: a clinical and pathophysiological review. 61
26375223 2015
38
Female pattern alopecia and telogen effluvium: figuring out diffuse alopecia. 61
26176282 2015
39
Compound heterozygous PLEC mutations in a patient of consanguineous parentage with epidermolysis bullosa simplex with muscular dystrophy and diffuse alopecia. 61
25209331 2015
40
Olmsted syndrome in an Iranian boy with a new de novo mutation in TRPV3. 61
24758389 2014
41
Diffuse alopecia in an adolescent female: tinea capitis. 61
24588014 2014
42
Zinc-deficiency acrodermatitis in a patient with chronic alcoholism and gastric bypass: a case report. 61
25147643 2014
43
Systemic light-chain amyloidosis revealed by progressive nail involvement, diffuse alopecia and sicca syndrome: report of an unusual case with a review of the literature. 61
24434547 2014
44
[Dermatomyositis and acute interstitial lung disease associated with MDA-5 antibodies: an atypical case]. 61
24090894 2013
45
Syphilitic alopecia: a report of 5 cases and a review of the literature. 61
22749730 2013
46
Olmsted syndrome. 61
23858339 2013
47
Equine multisystemic eosinophilic epitheliotropic disease: a case report and review of literature. 61
23441858 2013
48
Development of diffuse alopecia with psoriasis-like eruptions during administration of infliximab for Crohn's disease. 61
22508420 2013
49
Intractable diffuse alopecia caused by multifactorial side-effects in treatment of acute lymphocytic leukemia: connection to iatrogenic failure of estrogen secretion. 61
22211668 2013
50
Diffuse alopecia areata is associated with intense inflammatory infiltration and CD8+ T cells in hair loss regions and an increase in serum IgE level. 61
23075639 2012

Variations for Diffuse Alopecia Areata

Expression for Diffuse Alopecia Areata

Search GEO for disease gene expression data for Diffuse Alopecia Areata.

Pathways for Diffuse Alopecia Areata

GO Terms for Diffuse Alopecia Areata

Cellular components related to Diffuse Alopecia Areata according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 SLITRK1 RAET1L LIPH CRISP1 AZGP1
2 extracellular space GO:0005615 9.02 RAET1L LIPH KRT35 CRISP1 AZGP1

Sources for Diffuse Alopecia Areata

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10 dbSNP
11 DGIdb
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31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
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48 NCI
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50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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