MCID: DFF010
MIFTS: 27

Diffuse Alopecia Areata

Categories: Immune diseases

Aliases & Classifications for Diffuse Alopecia Areata

MalaCards integrated aliases for Diffuse Alopecia Areata:

Name: Diffuse Alopecia Areata 12 15 72
Diffuse Alopecia 44 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0060157
MeSH 44 C531609
UMLS 72 C0263479 C0406458 C1274706 more

Summaries for Diffuse Alopecia Areata

Disease Ontology : 12 An alopecia areata that involves diffuse loss of hair over the whole scalp.

MalaCards based summary : Diffuse Alopecia Areata, also known as diffuse alopecia, is related to palmoplantar keratoderma, mutilating, with periorificial keratotic plaques, x-linked and palmoplantar keratoderma, mutilating, with periorificial keratotic plaques. An important gene associated with Diffuse Alopecia Areata is KLRK1 (Killer Cell Lectin Like Receptor K1), and among its related pathways/superpathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include skin, t cells and lung.

Related Diseases for Diffuse Alopecia Areata

Diseases related to Diffuse Alopecia Areata via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 palmoplantar keratoderma, mutilating, with periorificial keratotic plaques, x-linked 11.4
2 palmoplantar keratoderma, mutilating, with periorificial keratotic plaques 11.4
3 epidermolysis bullosa simplex, generalized, with scarring and hair loss 11.2
4 alopecia areata 10.5
5 alopecia 10.5
6 telogen effluvium 10.2
7 alopecia, androgenetic, 1 10.0
8 vitiligo-associated multiple autoimmune disease susceptibility 6 10.0
9 alopecia universalis congenita 10.0
10 myasthenia gravis 10.0
11 vitiligo-associated multiple autoimmune disease susceptibility 1 10.0
12 graft-versus-host disease 10.0
13 androgenic alopecia 10.0
14 folliculitis 10.0
15 pemphigus 10.0
16 hypereosinophilic syndrome 10.0
17 alopecia totalis 10.0
18 pemphigus foliaceus 10.0
19 syphilis 10.0
20 epidermolysis bullosa simplex with muscular dystrophy 9.9
21 epidermolysis bullosa 9.9
22 secondary syphilis 9.9
23 pustulosis of palm and sole 9.9
24 epidermolysis bullosa simplex 9.9
25 crohn's disease 9.9
26 psoriasis 9.9
27 amyloidosis 9.9
28 muscular dystrophy 9.9
29 al amyloidosis 9.9
30 hashimoto thyroiditis 9.8
31 adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency 9.8
32 immune deficiency disease 9.8
33 leprosy 3 9.8
34 hyperprolactinemia 9.8
35 deficiency anemia 9.8
36 exanthem 9.8
37 early congenital syphilis 9.8
38 autosomal recessive disease 9.8
39 hypogonadotropic hypogonadism 9.8
40 lymphocytic leukemia 9.8
41 lepromatous leprosy 9.8
42 ovarian disease 9.8
43 anhidrosis 9.8
44 primary hyperparathyroidism 9.8
45 hyperandrogenism 9.8
46 iron deficiency anemia 9.8
47 hyperparathyroidism 9.8
48 amenorrhea 9.8
49 hypothyroidism 9.8
50 lymphadenitis 9.8

Graphical network of the top 20 diseases related to Diffuse Alopecia Areata:



Diseases related to Diffuse Alopecia Areata

Symptoms & Phenotypes for Diffuse Alopecia Areata

Drugs & Therapeutics for Diffuse Alopecia Areata

Search Clinical Trials , NIH Clinical Center for Diffuse Alopecia Areata

Cochrane evidence based reviews: diffuse alopecia

Genetic Tests for Diffuse Alopecia Areata

Anatomical Context for Diffuse Alopecia Areata

MalaCards organs/tissues related to Diffuse Alopecia Areata:

41
Skin, T Cells, Lung, Thyroid, Bone, Bone Marrow, Cortex

Publications for Diffuse Alopecia Areata

Articles related to Diffuse Alopecia Areata:

(show top 50) (show all 222)
# Title Authors PMID Year
1
[Alopecia, deformed ear and mental retardation associated with terminal 21q deletion]. 38
30922549 2019
2
Hedgehog-like moustache trichomegaly during treatment with vismodegib. 38
31393645 2019
3
Olmsted syndrome with alopecia universalis caused by heterozygous mutation in PERP. 38
31361044 2019
4
2-deoxy D-glucose treatment does not elicit a hair growth response in alopecia areata. 38
31323149 2019
5
Pathogenesis and clinical features of alopecia in epidermolysis bullosa: A systematic review. 38
31177584 2019
6
Assessment of Quality of Life and Treatment Outcomes of Patients With Persistent Postchemotherapy Alopecia. 38
30840033 2019
7
Non-scarring alopecia in systemic lupus erythematosus: a cross-sectional study with trichoscopic, histopathological and immunopathological analyses. 38
31150712 2019
8
Debilitating disease in a polyparasitised woylie (Bettongia penicillata): A diagnostic investigation. 38
30094176 2018
9
Sequential cyclic changes of hair roots revealed by dermoscopy demonstrate a progressive mechanism of diffuse alopecia areata over time. 38
30307062 2018
10
Nonspecific diffuse alopecia as a single manifestation of syphilis infection: clinical and trichoscopic features. 38
29336022 2018
11
A novel PLEC nonsense homozygous mutation (c.7159G > T; p.Glu2387*) causes epidermolysis bullosa simplex with muscular dystrophy and diffuse alopecia: a case report. 38
29352809 2018
12
Hair Loss: Evidence to Thallium Poisoning. 38
30046496 2018
13
Toxic epidermal necrolysis in a female with metastatic breast cancer treated with vinorelbine. 38
29983677 2017
14
Unsuccessful Treatment of Alopecia Areata with Simvastatin/Ezetimibe: Experience in 12 Patients. 38
28879192 2017
15
Permanent diffuse alopecia after haematopoietic stem cell transplantation in childhood. 38
28319079 2017
16
Laryngeal Neuropathy in Adult Goats With Copper Deficiency. 38
28622494 2017
17
Value of dermoscopy for the diagnosis of monilethrix. 38
29469711 2017
18
Late-onset robust curly hair growth in a patient with BRAF-mutated metastatic melanoma responding to dabrafenib. 38
26946529 2017
19
[Psoriasis capitis and seborrhoic eczema of scalp diseases]. 38
28567508 2017
20
Lithium: one drug, five complications. 38
29276608 2017
21
Acute Alopecia: Evidence to Thallium Poisoning. 38
28761262 2017
22
Presence of Mast Cells and Mast Cell Degranulation in Scalp Biopsies of Telogen Effluvium. 38
28761261 2017
23
Morphological variability of Demodex cati in a feline immunodeficiency virus-positive cat. 38
27875092 2016
24
Acrodermatitis enteropathica in a pair of twins. 38
28435477 2016
25
Severe Infliximab-Induced Alopecia and Scalp Psoriasis in a Woman with Crohn's Disease: Dramatic Improvement after Drug Discontinuation and Treatment with Adjuvant Systemic and Topical Therapies. 38
27844446 2016
26
[What is new in basal cell carcinoma?] 38
27654826 2016
27
Loose Anchoring of Anagen Hairs and Pili Torti due to Erlotinib. 38
28442878 2016
28
Halo naevi, vitiligo and diffuse alopecia areata associated with tocilizumab therapy. 38
27516894 2016
29
Two familial cases of Olmsted-like syndrome with a G573V mutation of the TRPV3 gene. 38
27273692 2016
30
Distinguishing diffuse alopecia areata (AA) from pattern hair loss (PHL) using CD3(+) T cells. 38
26851831 2016
31
Trichodynia: a review of the literature. 38
26696219 2016
32
Phrynoderma and acquired acrodermatitis enteropathica in breastfeeding women after bariatric surgery. 38
26513075 2015
33
[Drug treatment of alopecia]. 38
26383761 2015
34
Female Pattern Hair Loss: a clinical and pathophysiological review. 38
26375223 2015
35
Female pattern alopecia and telogen effluvium: figuring out diffuse alopecia. 38
26176282 2015
36
Compound heterozygous PLEC mutations in a patient of consanguineous parentage with epidermolysis bullosa simplex with muscular dystrophy and diffuse alopecia. 38
25209331 2015
37
Olmsted syndrome in an Iranian boy with a new de novo mutation in TRPV3. 38
24758389 2014
38
Diffuse alopecia in an adolescent female: tinea capitis. 38
24588014 2014
39
Zinc-deficiency acrodermatitis in a patient with chronic alcoholism and gastric bypass: a case report. 38
25147643 2014
40
Systemic light-chain amyloidosis revealed by progressive nail involvement, diffuse alopecia and sicca syndrome: report of an unusual case with a review of the literature. 38
24434547 2014
41
[Dermatomyositis and acute interstitial lung disease associated with MDA-5 antibodies: an atypical case]. 38
24090894 2013
42
Syphilitic alopecia: a report of 5 cases and a review of the literature. 38
22749730 2013
43
Olmsted syndrome. 38
23858339 2013
44
Equine multisystemic eosinophilic epitheliotropic disease: a case report and review of literature. 38
23441858 2013
45
Development of diffuse alopecia with psoriasis-like eruptions during administration of infliximab for Crohn's disease. 38
22508420 2013
46
Intractable diffuse alopecia caused by multifactorial side-effects in treatment of acute lymphocytic leukemia: connection to iatrogenic failure of estrogen secretion. 38
22211668 2013
47
Diffuse alopecia areata is associated with intense inflammatory infiltration and CD8+ T cells in hair loss regions and an increase in serum IgE level. 38
23075639 2012
48
Clinical and histological challenge in the differential diagnosis of diffuse alopecia: female androgenetic alopecia, telogen effluvium and alopecia areata--part II. 38
23197208 2012
49
Clinical and histological challenge in the differential diagnosis of diffuse alopecia: female androgenetic alopecia, telogen effluvium and alopecia areata - part I. 38
23044568 2012
50
Amelanocytic anhidrotic alopecia areata-like phenotype after allogeneic hematopoietic cell transplant. 38
22911189 2012

Variations for Diffuse Alopecia Areata

Expression for Diffuse Alopecia Areata

Search GEO for disease gene expression data for Diffuse Alopecia Areata.

Pathways for Diffuse Alopecia Areata

Pathways related to Diffuse Alopecia Areata according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 KLRK1 CD8A
2 11.02 KLRK1 CD8A
3 10.53 KLRK1 CD8A

GO Terms for Diffuse Alopecia Areata

Cellular components related to Diffuse Alopecia Areata according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 8.96 KLRK1 CD8A
2 external side of plasma membrane GO:0009897 8.62 KLRK1 CD8A

Biological processes related to Diffuse Alopecia Areata according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 8.96 KLRK1 CD8A
2 regulation of immune response GO:0050776 8.62 KLRK1 CD8A

Molecular functions related to Diffuse Alopecia Areata according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class I protein binding GO:0042288 8.62 KLRK1 CD8A

Sources for Diffuse Alopecia Areata

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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