MCID: DFF031
MIFTS: 28

Diffuse Alveolar Hemorrhage

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Diffuse Alveolar Hemorrhage

MalaCards integrated aliases for Diffuse Alveolar Hemorrhage:

Name: Diffuse Alveolar Hemorrhage 59

Characteristics:

Orphanet epidemiological data:

59
diffuse alveolar hemorrhage
Prevalence: 1-9/100000 (Europe);

Classifications:

Orphanet: 59  
Rare respiratory diseases


External Ids:

ICD10 via Orphanet 34 J98.4
Orphanet 59 ORPHA90060

Summaries for Diffuse Alveolar Hemorrhage

MalaCards based summary : Diffuse Alveolar Hemorrhage is related to adult-onset still's disease and respiratory failure. An important gene associated with Diffuse Alveolar Hemorrhage is CYP2C9 (Cytochrome P450 Family 2 Subfamily C Member 9). The drugs Pentostatin and Lorazepam have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and bone marrow.

Related Diseases for Diffuse Alveolar Hemorrhage

Diseases related to Diffuse Alveolar Hemorrhage via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 225)
# Related Disease Score Top Affiliating Genes
1 adult-onset still's disease 11.7
2 respiratory failure 10.8
3 vasculitis 10.8
4 systemic lupus erythematosus 10.7
5 lupus erythematosus 10.7
6 glomerulonephritis 10.6
7 granulomatosis with polyangiitis 10.5
8 acute respiratory distress syndrome 10.5
9 microscopic polyangiitis 10.5
10 antiphospholipid syndrome 10.5
11 autoimmune disease 10.5
12 anca-associated vasculitis 10.5
13 hematopoietic stem cell transplantation 10.4
14 hemosiderosis 10.3
15 purpura 10.3
16 rapidly progressive glomerulonephritis 10.3
17 lung disease 10.3
18 pulmonary hemosiderosis 10.3
19 pulmonary edema 10.3
20 idiopathic interstitial pneumonia 10.3
21 acute kidney failure 10.3
22 scleroderma, familial progressive 10.3
23 thrombocytopenia 10.3
24 pulmonary fibrosis 10.3
25 pneumonia 10.3
26 goodpasture syndrome 10.3
27 angiosarcoma 10.3
28 endocarditis 10.3
29 crescentic glomerulonephritis 10.3
30 vascular disease 10.3
31 leptospirosis 10.3
32 interstitial lung disease 10.3
33 connective tissue disease 10.3
34 aspergillosis 10.2
35 hemophilia 10.2
36 rheumatoid arthritis 10.2
37 thrombophilia due to thrombin defect 10.2
38 hydrops, lactic acidosis, and sideroblastic anemia 10.2
39 cardiac arrest 10.2
40 acute poststreptococcal glomerulonephritis 10.2
41 ischemia 10.2
42 pulmonary embolism 10.2
43 eosinophilic granulomatosis with polyangiitis 10.2
44 isolated pulmonary capillaritis 10.2
45 factor viii deficiency 10.1
46 thrombocytopenic purpura, autoimmune 10.1
47 hemophilia a 10.1
48 leukemia, acute myeloid 10.1
49 cryptogenic organizing pneumonia 10.1
50 exanthem 10.1

Graphical network of the top 20 diseases related to Diffuse Alveolar Hemorrhage:



Diseases related to Diffuse Alveolar Hemorrhage

Symptoms & Phenotypes for Diffuse Alveolar Hemorrhage

Drugs & Therapeutics for Diffuse Alveolar Hemorrhage

Drugs for Diffuse Alveolar Hemorrhage (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pentostatin Approved, Investigational Phase 2 53910-25-1 40926 439693
2
Lorazepam Approved Phase 2 846-49-1 3958
3
Adenosine Approved, Investigational Phase 2 58-61-7 60961
4
rituximab Approved Phase 2 174722-31-7 10201696
5
Busulfan Approved, Investigational Phase 2 55-98-1 2478
6 Alkylating Agents Phase 2
7 Immunosuppressive Agents Phase 2
8 Antineoplastic Agents, Immunological Phase 2
9 Immunologic Factors Phase 2
10 Antirheumatic Agents Phase 2
11 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Trial of Pentostatin and Targeted Busulfan as a Novel Reduced Intensity Regimen for Allogeneic Hematopoietic Stem Cell Transplantation Using Laboratory-Guided (CD4-guided) Immunosuppression. Completed NCT00496340 Phase 2 Pentostatin;Busulfan;Rituximab

Search NIH Clinical Center for Diffuse Alveolar Hemorrhage

Genetic Tests for Diffuse Alveolar Hemorrhage

Anatomical Context for Diffuse Alveolar Hemorrhage

MalaCards organs/tissues related to Diffuse Alveolar Hemorrhage:

41
Lung, Bone, Bone Marrow, Neutrophil, Kidney, Breast, B Cells

Publications for Diffuse Alveolar Hemorrhage

Articles related to Diffuse Alveolar Hemorrhage:

(show top 50) (show all 722)
# Title Authors PMID Year
1
Extracorporeal Membrane Oxygenation for Diffuse Alveolar Hemorrhage Caused by Idiopathic Pulmonary Hemosiderosis: A Case Report and a Review of the Literature. 38
31404435 2019
2
High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage. 38
31391335 2019
3
Allogeneic reactivity-mediated endothelial cell complications after HSCT: a plea for consensual definitions. 38
31409584 2019
4
A relapsing case of pulmonary-renal syndrome after a sequential rise in MPO-ANCA and anti-GBM antibodies. 38
30945174 2019
5
Diffuse alveolar hemorrhage following intravenous thrombolytic treatment in acute ischemic stroke: a case series. 38
31280387 2019
6
Strongyloidiasis hyperinfection after renal transplant presenting as diffuse alveolar hemorrhage with respiratory failure. 38
31384205 2019
7
Delayed Intracerebral Hemorrhage after Synthetic Cannabis (Bonsai) Abuse; Case Report and Literature Review. 38
31392236 2019
8
Outcomes of Hematopoietic Cell Transplantation in Patients with Germline SAMD9/SAMD9L Mutations. 38
31306780 2019
9
Unilateral diffuse alveolar hemorrhage in granulomatosis with polyangiitis. 38
31332692 2019
10
Use of Plasmapheresis and Immunosuppressants to Treat Diffuse Alveolar Hemorrhage in a Patient with Granulomatosis with Polyangiitis. 38
31315254 2019
11
Catastrophic antiphospholipid syndrome as a complication of systemic sclerosis. 38
31309781 2019
12
Plasma Exchange Therapy to Reduce Mortality in Japanese Patients With Diffuse Alveolar Hemorrhage and Microscopic Polyangiitis. 38
31233282 2019
13
Thoracic Manifestations of Connective Tissue Diseases. 38
31200872 2019
14
Complications of Stem Cell Transplantation that Affect Infections in Stem Cell Transplant Recipients, with Analogies to Patients with Hematologic Malignancies. 38
30940464 2019
15
An uncommon cause of diffuse alveolar hemorrhage in a young male. 38
31170777 2019
16
Neutrophil extracellular traps are associated with the pathogenesis of diffuse alveolar hemorrhage in murine lupus. 38
30930069 2019
17
Acute pulmonary embolism in a child with ANCA-negative Idiopathic Pulmonary Capillaritis. 38
31219497 2019
18
Efficacy of Plasma Exchange in Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis. 38
31033197 2019
19
Unilateral diffuse alveolar hemorrhage in a patient with granulomatous polyangiitis. 38
31230807 2019
20
Coexistence of Diffuse Alveolar Hemorrhage and Pulmonary Thromboembolism. 38
31178517 2019
21
Pot smokers puffing away lung health. 38
31128895 2019
22
A case of severe pneumonitis with alveolar hemorrhage associated with herbal medicines. 38
31105121 2019
23
Potential role of CT-textural features for differentiation between viral interstitial pneumonias, pneumocystis jirovecii pneumonia and diffuse alveolar hemorrhage in early stages of disease: a proof of principle. 38
31113389 2019
24
Diffuse alveolar hemorrhage caused by IgA deposition associated with multiple myeloma. 38
31110743 2019
25
Lung Disease in Antiphospholipid Syndrome. 38
31137066 2019
26
Pulmonary Complications of Systemic Lupus Erythematosus. 38
31137062 2019
27
Diffuse Alveolar Hemorrhage Following Pirfenidone Initiation. 38
30987503 2019
28
Influenza A Pneumonia Associated with Diffuse Alveolar Hemorrhage. A Case Report and Literature Review. 38
31019189 2019
29
Association between preexisting lung involvements and the risk of diffuse alveolar hemorrhage in patients with microscopic polyangiitis: A multi-center retrospective cohort study. 38
30929541 2019
30
Transplant-Associated Thrombotic Microangiopathy Is a Multifactorial Disease Unresponsive to Immunosuppressant Withdrawal. 38
30940363 2019
31
Diffuse alveolar hemorrhage in a patient with ANCA-associated vasculitis after thyroidectomy: A case report. 38
30813199 2019
32
Diffuse alveolar hemorrhage following sugammadex and remifentanil administration: A case report. 38
30813195 2019
33
Long term veno-venous extracorporeal life support without intravenous anticoagulation for diffuse alveolar hemorrhage. 38
30744494 2019
34
Diffuse Alveolar Hemorrhage Caused by Warfarin after Rifampicin Discontinuation. 38
30809261 2019
35
Hyaluronic acid-induced diffuse alveolar hemorrhage: unknown complication induced by a well-known injectable agent. 38
30788360 2019
36
Recreational 'mud fever': Leptospira interrogans induced diffuse alveolar hemorrhage and severe acute respiratory distress syndrome in a U.S. Navy seaman following 'mud-run' in Hawaii. 38
30976519 2019
37
Surgery for Bacterial Endocarditis Complicated by Diffuse Alveolar Hemorrhage. 38
31275663 2019
38
Negative pressure pulmonary edema-related diffuse alveolar hemorrhage associated with Sevoflurane and cigarette smoking. 38
31258867 2019
39
A Rare Case of Hemophagocytic Lymphohistiocytosis in an Adult with Diffuse Large B-Cell Lymphoma. 38
31360558 2019
40
Choriocarcinoma Syndrome: A Potentially Fatal Complication of Testicular Cancer. 38
30918732 2019
41
Antibody-Negative Relapse of Goodpasture Syndrome with Pulmonary Hemorrhage. 38
31178913 2019
42
Therapeutic Plasma Exchange as Management of Complicated Systemic Lupus Erythematosus and Other Autoimmune Diseases. 38
30984421 2019
43
A different clinical presentation of Heiner syndrome: The case of diffuse alveolar hemorrhage causing massive hemoptysis and hematemesis. 38
30733916 2019
44
Successful use of rituximab for hydralazine-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis. 38
30804286 2019
45
Refractory diffuse alveolar hemorrhage caused by eosinophilic granulomatosis with polyangiitis in the absence of elevated biomarkers treated successfully by rituximab and mepolizumab: A case report. 38
30603598 2019
46
Successful Management of Immune Thrombocytopenia Presenting with Lethal Alveolar Hemorrhage. 38
31281686 2019
47
Recurrent Episodes of Diffuse Alveolar Hemorrhage in Systemic Sclerosis 30 Days Apart. 38
31053041 2019
48
Pulmonary manifestations of large, medium, and variable vessel vasculitis. 38
30509707 2018
49
Silicone pneumonitis, diffuse alveolar hemorrhage and acute respiratory distress syndrome from gluteal silicone injections. 38
30224271 2018
50
Effect of plasma exchange in acute respiratory failure due to Anti-neutrophil cytoplasmic antibody-associated vasculitis. 38
30514337 2018

Variations for Diffuse Alveolar Hemorrhage

Expression for Diffuse Alveolar Hemorrhage

Search GEO for disease gene expression data for Diffuse Alveolar Hemorrhage.

Pathways for Diffuse Alveolar Hemorrhage

GO Terms for Diffuse Alveolar Hemorrhage

Biological processes related to Diffuse Alveolar Hemorrhage according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 8.96 VKORC1 CYP2C9
2 drug metabolic process GO:0017144 8.62 VKORC1 CYP2C9

Molecular functions related to Diffuse Alveolar Hemorrhage according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 8.62 VKORC1 CYP2C9

Sources for Diffuse Alveolar Hemorrhage

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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