MCID: DFF031
MIFTS: 26

Diffuse Alveolar Hemorrhage

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Diffuse Alveolar Hemorrhage

MalaCards integrated aliases for Diffuse Alveolar Hemorrhage:

Name: Diffuse Alveolar Hemorrhage 58

Characteristics:

Orphanet epidemiological data:

58
diffuse alveolar hemorrhage
Prevalence: 1-9/100000 (Europe);

Classifications:

Orphanet: 58  
Rare respiratory diseases


External Ids:

ICD10 via Orphanet 33 J98.4
Orphanet 58 ORPHA90060

Summaries for Diffuse Alveolar Hemorrhage

MalaCards based summary : Diffuse Alveolar Hemorrhage is related to adult-onset still's disease and respiratory failure. An important gene associated with Diffuse Alveolar Hemorrhage is CYP2C9 (Cytochrome P450 Family 2 Subfamily C Member 9). The drugs Lorazepam and Adenosine have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and bone marrow.

Related Diseases for Diffuse Alveolar Hemorrhage

Diseases related to Diffuse Alveolar Hemorrhage via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 234)
# Related Disease Score Top Affiliating Genes
1 adult-onset still's disease 11.7
2 respiratory failure 10.8
3 vasculitis 10.8
4 systemic lupus erythematosus 10.7
5 lupus erythematosus 10.7
6 glomerulonephritis 10.6
7 granulomatosis with polyangiitis 10.5
8 antiphospholipid syndrome 10.5
9 microscopic polyangiitis 10.5
10 autoimmune disease 10.5
11 anca-associated vasculitis 10.5
12 hemosiderosis 10.4
13 rapidly progressive glomerulonephritis 10.4
14 pulmonary hemosiderosis 10.3
15 pulmonary edema 10.3
16 thrombocytopenia 10.3
17 purpura 10.3
18 lung disease 10.3
19 idiopathic interstitial pneumonia 10.3
20 acute kidney failure 10.3
21 pneumonia 10.3
22 scleroderma, familial progressive 10.3
23 endocarditis 10.3
24 pulmonary fibrosis 10.3
25 goodpasture syndrome 10.3
26 angiosarcoma 10.3
27 crescentic glomerulonephritis 10.3
28 vascular disease 10.3
29 leptospirosis 10.3
30 interstitial lung disease 10.3
31 connective tissue disease 10.3
32 thrombophilia due to thrombin defect 10.2
33 aspergillosis 10.2
34 pulmonary embolism 10.2
35 hemophilia 10.2
36 rheumatoid arthritis 10.2
37 leukemia, acute myeloid 10.2
38 hydrops, lactic acidosis, and sideroblastic anemia 10.2
39 cardiac arrest 10.2
40 acute poststreptococcal glomerulonephritis 10.2
41 nonspecific interstitial pneumonia 10.2
42 churg-strauss syndrome 10.2
43 ischemia 10.2
44 eosinophilic pneumonia 10.2
45 myeloid leukemia 10.2
46 isolated pulmonary capillaritis 10.2
47 factor viii deficiency 10.1
48 myositis 10.1
49 thrombocytopenic purpura, autoimmune 10.1
50 hemophilia a 10.1

Graphical network of the top 20 diseases related to Diffuse Alveolar Hemorrhage:



Diseases related to Diffuse Alveolar Hemorrhage

Symptoms & Phenotypes for Diffuse Alveolar Hemorrhage

Drugs & Therapeutics for Diffuse Alveolar Hemorrhage

Drugs for Diffuse Alveolar Hemorrhage (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lorazepam Approved Phase 2 846-49-1 3958
2
Adenosine Approved, Investigational Phase 2 58-61-7 60961
3
Busulfan Approved, Investigational Phase 2 55-98-1 2478
4
rituximab Approved Phase 2 174722-31-7 10201696
5
Pentostatin Approved, Investigational Phase 2 53910-25-1 40926 439693
6 Immunologic Factors Phase 2
7 Alkylating Agents Phase 2
8 Antineoplastic Agents, Immunological Phase 2
9 Antirheumatic Agents Phase 2
10 Immunosuppressive Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Trial of Pentostatin and Targeted Busulfan as a Novel Reduced Intensity Regimen for Allogeneic Hematopoietic Stem Cell Transplantation Using Laboratory-Guided (CD4-guided) Immunosuppression. Completed NCT00496340 Phase 2 Pentostatin;Busulfan;Rituximab
2 TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients Not yet recruiting NCT04098445

Search NIH Clinical Center for Diffuse Alveolar Hemorrhage

Genetic Tests for Diffuse Alveolar Hemorrhage

Anatomical Context for Diffuse Alveolar Hemorrhage

MalaCards organs/tissues related to Diffuse Alveolar Hemorrhage:

40
Lung, Bone, Bone Marrow, T Cells, Kidney, B Cells, Neutrophil

Publications for Diffuse Alveolar Hemorrhage

Articles related to Diffuse Alveolar Hemorrhage:

(show top 50) (show all 759)
# Title Authors PMID Year
1
Systemic lupus erythematosus and diffuse alveolar hemorrhage, etiology and novel treatment strategies. 61
32036761 2020
2
Unique case of ANCA-negative pauci-immune necrotizing glomerulonephritis with diffuse alveolar hemorrhage, potentially associated with midostaurin. 61
31955389 2020
3
Isolated Pauci-Immune Pulmonary Capillaritis Associated with Hydrocarbon Inhalation and Marijuana Smoking: An Unusual Case of Severe Hypoxemia. 61
32015926 2020
4
Vaping-induced diffuse alveolar hemorrhage. 61
31956478 2020
5
A Case of Vaping TCH Oil Leading to Vaping Associated Pulmonary Injury: Our Approach to Its Diagnosis, Management, and Recommendations. 61
31976113 2020
6
Radiologic, Pathologic, Clinical, and Physiologic Findings of Electronic Cigarette or Vaping Product Use-associated Lung Injury (EVALI): Evolving Knowledge and Remaining Questions. 61
31990264 2020
7
Unilateral diffuse alveolar hemorrhage in a patient with granulomatous polyangiitis. 61
31230807 2020
8
Diffuse alveolar hemorrhage following intravenous thrombolytic treatment in acute ischemic stroke: a case series. 61
31280387 2020
9
Severe Pneumonitis with Alveolar Hemorrhage Associated with Herbal Medicines: A Case Report. 61
31105121 2019
10
Diffuse Alveolar Hemorrhage: An Uncommon Manifestation of Vaping-associated Lung Injury. 61
32025438 2019
11
Hemoptysis and a cardiac murmur: is it primary or secondary antiphospholipid syndrome? 61
31718483 2019
12
Concurrent treatment with rituximab and plasma exchange for severe refractory granulomatosis with polyangiitis: A case report. 61
31860960 2019
13
Diffuse Alveolar Hemorrhage: A Cohort of Patients With Systemic Lupus Erythematosus. 61
31895107 2019
14
[What are the indications for rescue procedures? : Systemic rheumatic diseases in the intensive care unit]. 61
31485728 2019
15
STING-Associated Vasculopathy with Onset in Infancy in Three Children with New Clinical Aspect and Unsatisfactory Therapeutic Responses to Tofacitinib. 61
31705453 2019
16
Outcomes of Hematopoietic Cell Transplantation in Patients with Germline SAMD9/SAMD9L Mutations. 61
31306780 2019
17
Warfarin-induced diffuse alveolar hemorrhage: Case report and a review of the literature. 61
31670302 2019
18
Henoch-Schönlein Purpura in children: not only kidney but also lung. 61
31752918 2019
19
Extracorporeal Membrane Oxygenation for Severe ARDS Due to Immune Diffuse Alveolar Hemorrhage: A Retrospective Observational Study. 61
31711988 2019
20
A rare case of Diffuse Alveolar Hemorrhage (DAH) due to Warfarin Toxicity. 61
31693498 2019
21
Pulmonary complications for drug consumption: Diffuse alveolar hemorrhage. 61
31771781 2019
22
Coexistence of Diffuse Alveolar Hemorrhage and Pulmonary Thromboembolism. 61
31178517 2019
23
[Acute Respiratory Failure after Silicone Injection]. 61
31499560 2019
24
Vaping-Associated Acute Respiratory Failure Due to Acute Lipoid Pneumonia. 61
31583455 2019
25
Unilateral diffuse alveolar hemorrhage in granulomatosis with polyangiitis. 61
31332692 2019
26
[Diffuse alveolar hemorrhage in children]. 61
31506159 2019
27
Clinical Insights into Diffuse Alveolar Hemorrhage in Antiphospholipid Syndrome. 61
31493005 2019
28
Extracorporeal Membrane Oxygenation for Diffuse Alveolar Hemorrhage Caused by Idiopathic Pulmonary Hemosiderosis: A Case Report and a Review of the Literature. 61
31404435 2019
29
Fat Embolism Syndrome Complicated by Diffuse Alveolar Hemorrhage: An Albino Zebra. 61
31638538 2019
30
Dabigatran-Associated Diffuse Alveolar Hemorrhage. 61
31567139 2019
31
Pot smokers puffing away lung health. 61
31128895 2019
32
A relapsing case of pulmonary-renal syndrome after a sequential rise in MPO-ANCA and anti-GBM antibodies. 61
30945174 2019
33
Alpha-1-Antitrypsin Ameliorates Pristane Induced Diffuse Alveolar Hemorrhage in Mice. 61
31470606 2019
34
Clinical Characteristics and Risk Factors of Diffuse Alveolar Hemorrhage in Systemic Lupus Erythematosus: a Systematic Review and Meta-Analysis Based on Observational Studies. 61
31440948 2019
35
High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage. 61
31391335 2019
36
Allogeneic reactivity-mediated endothelial cell complications after HSCT: a plea for consensual definitions. 61
31409584 2019
37
Independent lung ventilation: Implementation strategies and review of literature. 61
31667133 2019
38
Strongyloidiasis hyperinfection after renal transplant presenting as diffuse alveolar hemorrhage with respiratory failure. 61
31384205 2019
39
Delayed Intracerebral Hemorrhage after Synthetic Cannabis (Bonsai) Abuse; Case Report and Literature Review. 61
31392236 2019
40
Use of Plasmapheresis and Immunosuppressants to Treat Diffuse Alveolar Hemorrhage in a Patient with Granulomatosis with Polyangiitis. 61
31315254 2019
41
Catastrophic antiphospholipid syndrome as a complication of systemic sclerosis. 61
31309781 2019
42
An Unusual Case of Diffuse Alveolar Hemorrhage as a Clinical Manifestation of Atypical Hemolytic Uremic Syndrome: A Case Report. 61
31516771 2019
43
Cannabis Smoking-induced Diffuse Alveolar Hemorrhage. 61
31511809 2019
44
Amiodarone-induced Hemoptysis: A Rare Presentation of Amiodarone-induced Pulmonary Toxicity Occurs at a Low Dose. 61
31576278 2019
45
Plasma Exchange Therapy to Reduce Mortality in Japanese Patients With Diffuse Alveolar Hemorrhage and Microscopic Polyangiitis. 61
31233282 2019
46
Thoracic Manifestations of Connective Tissue Diseases. 61
31200872 2019
47
A Rare Case of Irinotecan-induced Interstitial Pulmonary Disease and Diffuse Alveolar Hemorrhage in a Patient with Pancreatic Cancer. 61
31501733 2019
48
An uncommon cause of diffuse alveolar hemorrhage in a young male. 61
31170777 2019
49
Neutrophil extracellular traps are associated with the pathogenesis of diffuse alveolar hemorrhage in murine lupus. 61
30930069 2019
50
Efficacy of Plasma Exchange in Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis. 61
31033197 2019

Variations for Diffuse Alveolar Hemorrhage

Expression for Diffuse Alveolar Hemorrhage

Search GEO for disease gene expression data for Diffuse Alveolar Hemorrhage.

Pathways for Diffuse Alveolar Hemorrhage

GO Terms for Diffuse Alveolar Hemorrhage

Biological processes related to Diffuse Alveolar Hemorrhage according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug metabolic process GO:0017144 8.62 VKORC1 CYP2C9

Molecular functions related to Diffuse Alveolar Hemorrhage according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 8.62 VKORC1 CYP2C9

Sources for Diffuse Alveolar Hemorrhage

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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