MCID: DFF031
MIFTS: 26

Diffuse Alveolar Hemorrhage

Categories: Respiratory diseases, Rare diseases

Aliases & Classifications for Diffuse Alveolar Hemorrhage

MalaCards integrated aliases for Diffuse Alveolar Hemorrhage:

Name: Diffuse Alveolar Hemorrhage 59

Characteristics:

Orphanet epidemiological data:

59
diffuse alveolar hemorrhage
Prevalence: 1-9/100000 (Europe);

Classifications:

Orphanet: 59  
Rare respiratory diseases


External Ids:

Orphanet 59 ORPHA90060
ICD10 via Orphanet 34 J98.4

Summaries for Diffuse Alveolar Hemorrhage

MalaCards based summary : Diffuse Alveolar Hemorrhage is related to lupus erythematosus and systemic lupus erythematosus. An important gene associated with Diffuse Alveolar Hemorrhage is CYP2C9 (Cytochrome P450 Family 2 Subfamily C Member 9). Affiliated tissues include lung, bone and bone marrow.

Related Diseases for Diffuse Alveolar Hemorrhage

Diseases related to Diffuse Alveolar Hemorrhage via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 lupus erythematosus 10.5
2 systemic lupus erythematosus 10.5
3 vasculitis 10.3
4 glomerulonephritis 10.2
5 antiphospholipid syndrome 10.1
6 wegener granulomatosis 10.1
7 hematopoietic stem cell transplantation 10.1
8 microscopic polyangiitis 10.1
9 respiratory failure 10.1
10 angiosarcoma 10.1
11 endocarditis 10.0
12 rheumatoid arthritis 10.0
13 arthritis 10.0
14 pneumonia 10.0
15 acute respiratory distress syndrome 10.0
16 leptospirosis 9.9
17 purpura 9.9
18 rapidly progressive glomerulonephritis 9.9
19 anca-associated vasculitis 9.9
20 leukemia 9.9
21 autoimmune disease 9.9
22 autoimmune disease 1 9.9
23 churg-strauss syndrome 9.9
24 isolated pulmonary capillaritis 9.9
25 ischemia 9.9
26 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
27 pulmonary edema 9.9
28 scleroderma, familial progressive 9.9
29 thrombocytopenic purpura, autoimmune 9.9
30 acute poststreptococcal glomerulonephritis 9.9
31 allergic angiitis 9.9
32 hemophilia b 9.7
33 mediastinitis 9.7
34 catastrophic antiphospholipid syndrome 9.7
35 leukemia, acute myeloid 9.7
36 pulmonary fibrosis 9.7
37 iga glomerulonephritis 9.7
38 influenza 9.7
39 hemorrhagic fever 9.7
40 spondyloarthropathy 1 9.7
41 aceruloplasminemia 9.7
42 thrombocytopenia 9.7
43 lung disease 9.7
44 impetigo 9.7
45 polymyositis 9.7
46 cardiac conduction defect 9.7
47 myocardial infarction 9.7
48 interstitial lung disease 9.7
49 hodgkin's lymphoma, lymphocytic-histiocytic predominance 9.7
50 renal cell carcinoma, nonpapillary 9.7

Graphical network of the top 20 diseases related to Diffuse Alveolar Hemorrhage:



Diseases related to Diffuse Alveolar Hemorrhage

Symptoms & Phenotypes for Diffuse Alveolar Hemorrhage

Drugs & Therapeutics for Diffuse Alveolar Hemorrhage

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Eltrombopag vs. rhTPO to Increase Platelet Level After HSCT Not yet recruiting NCT03515096 Phase 3 Eltrombopag;rhTPO

Search NIH Clinical Center for Diffuse Alveolar Hemorrhage

Genetic Tests for Diffuse Alveolar Hemorrhage

Anatomical Context for Diffuse Alveolar Hemorrhage

MalaCards organs/tissues related to Diffuse Alveolar Hemorrhage:

41
Lung, Bone, Bone Marrow, B Cells, Neutrophil, Myeloid, Testes

Publications for Diffuse Alveolar Hemorrhage

Articles related to Diffuse Alveolar Hemorrhage:

(show top 50) (show all 291)
# Title Authors Year
1
Diffuse Alveolar Hemorrhage in IgA Vasculitis with an Atypical Presentation. ( 29033424 )
2018
2
Mediastinal angiosarcoma presenting as diffuse alveolar hemorrhage. ( 29719795 )
2018
3
B-cell-depleting therapy for diffuse alveolar hemorrhage in systemic lupus erythematosus. ( 29907447 )
2018
4
Difficulties in the treatment of recurring diffuse alveolar hemorrhage accompanying primary antiphospholipid syndrome: a case report and literature review. ( 29960279 )
2018
5
Successful treatment with idarucizumab for diffuse alveolar hemorrhage induced by dabigatran etexilate: a case report. ( 29740732 )
2018
6
Diffuse Alveolar Hemorrhage Developing Immediately after Immunosuppressive Treatments in a Patient with Granulomatosis with Polyangiitis Who Had Pulmonary Nodules. ( 29093401 )
2018
7
Pulmonary renal syndrome: A case report of diffuse alveolar hemorrhage in association with ANCA negative pauci-immune glomerulonephritis. ( 29879042 )
2018
8
A fatal case of diffuse alveolar hemorrhage as the initial presentation of systemic lupus erythematosus: A case report and literature review. ( 29977760 )
2018
9
Diffuse Alveolar Hemorrhage without Extrapulmonary Manifestations: A Rare Presentation of Lupus. ( 29487279 )
2018
10
Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages. ( 29456535 )
2018
11
Alveolar levels of immuno-inflammatory mediators in diffuse alveolar hemorrhage after allogeneic transplant. ( 29670209 )
2018
12
Methylprednisolone and plasmapheresis are effective for life-threatening diffuse alveolar hemorrhage and gastrointestinal hemorrhage in granulomatosis with polyangiitis: A case report and literature review. ( 29703056 )
2018
13
Pulmonary manifestations in systemic lupus erythematosus: pleural involvement, acute pneumonitis, chronic interstitial lung disease and diffuse alveolar hemorrhage. ( 29773465 )
2018
14
Diffuse alveolar hemorrhage associated with ticagrelor therapy after percutaneous coronary intervention. ( 29952365 )
2018
15
Granulomatosis with polyangiitis presenting with diffuse alveolar hemorrhage requiring extracorporeal membrane oxygenation with rapid multiorgan relapse: A case report. ( 28353556 )
2017
16
Diffuse Alveolar Hemorrhage as a Complication of Intrapleural Fibrinolytic Therapy. ( 28957896 )
2017
17
Continous Rituximab treatment for recurrent diffuse alveolar hemorrhage in a patient with systemic lupus erythematosus and antiphosholipid syndrome. ( 29021954 )
2017
18
Diffuse Alveolar Hemorrhage Induced by Irinotecan for a Patient with Metastatic Thymic Carcinoma: A Case Report and Literature Review. ( 28674360 )
2017
19
Immune diffuse alveolar hemorrhage: Clinical presentation and outcome. ( 28732837 )
2017
20
Pathogenesis of Diffuse Alveolar Hemorrhage in Murine Lupus. ( 28217966 )
2017
21
Diffuse Alveolar Hemorrhage in Autoimmune Diseases. ( 28397125 )
2017
22
A Pediatric Case of Diffuse Alveolar Hemorrhage Secondary to Poststreptococcal Glomerulonephritis. ( 29423322 )
2017
23
Repeated Diffuse Alveolar Hemorrhage in a Patient with Hemophilia B. ( 28202865 )
2017
24
An interesting case of mycoplasma pneumonia associated multisystem involvement and diffuse alveolar hemorrhage. ( 28413775 )
2017
25
Clinical Features of Patients with Diffuse Alveolar Hemorrhage due to Negative-Pressure Pulmonary Edema. ( 28455784 )
2017
26
The Effects of Plasma Exchange on Severe Vasculitis with Diffuse Alveolar Hemorrhage. ( 28050000 )
2017
27
Microscopic polyangiitis: Atypical presentation with extensive small bowel necrosis, diffuse alveolar hemorrhage, and renal failure. ( 28348948 )
2017
28
Legionella pneumonia associated with severe acute respiratory distress syndrome and diffuse alveolar hemorrhage - A rare association. ( 28348947 )
2017
29
A Case of Rare Diffuse Alveolar Hemorrhage and Review of Literature. ( 29104431 )
2017
30
Diffuse Alveolar Hemorrhage in Systemic Lupus Erythematosus: Histopathologic Features and Clinical Correlations. ( 28536665 )
2017
31
Diffuse alveolar hemorrhage as an initial presentation of ANCAa89associated vasculitis in an 80a89yeara89old man. ( 28581453 )
2017
32
Pneumonitis with Diffuse Alveolar Hemorrhage Induced by Sho-seiryu-to. ( 28883249 )
2017
33
Sevoflurane Induced Diffuse Alveolar Hemorrhage in a young patient. ( 27872805 )
2017
34
Concomitant Diffuse Alveolar Hemorrhage and Pulmonary Embolism in a Child with Isolated Pulmonary Capillaritis. ( 28248576 )
2017
35
Local Anesthetic Lidocaine for Gastroscopy Induces Diffuse Alveolar Hemorrhage. ( 28685738 )
2017
36
A Case of Diffuse Alveolar Hemorrhage as a Possible Complication of Bivalirudin Therapy. ( 28993605 )
2017
37
Bronchial damage and diffuse alveolar hemorrhage following chlorine gas inhalation: A case report. ( 29201226 )
2017
38
What Can We Do When All Collapses? Fatal Outcome of Collapsing Glomerulopathy and Systemic Lupus Erythematosus With Diffuse Alveolar Hemorrhage: Case Report. ( 28457424 )
2017
39
Efficacy of Rituximab in a Systemic Lupus Erythematosus Patient Presenting with Diffuse Alveolar Hemorrhage. ( 29259835 )
2017
40
Clinical Features and Outcomes of Diffuse Alveolar Hemorrhage During Antithrombotic Therapy: A Retrospective Cohort Study. ( 27044406 )
2016
41
Analysis of three cases of diffuse alveolar hemorrhage: False-negative results in pulmonary ultrasound. ( 28027784 )
2016
42
Diffuse Alveolar Hemorrhage Associated with Edoxaban Therapy. ( 27872767 )
2016
43
Cocaine-induced diffuse alveolar hemorrhage: A case report and review of the literature. ( 27472774 )
2016
44
Double Trouble: The Diagnostic Dilemma of Diffuse Alveolar Hemorrhage. ( 27036393 )
2016
45
Diffuse Alveolar Hemorrhage in Acute Myeloid Leukemia. ( 27556667 )
2016
46
Diffuse Alveolar Hemorrhage in Patients Undergoing Neurointervention: A Case Report. ( 27843786 )
2016
47
Sirolimus-Induced Diffuse Alveolar Hemorrhage: A Case Report. ( 26849007 )
2016
48
Clinical characteristics and outcomes of diffuse alveolar hemorrhage in patients with systemic lupus erythematosus. ( 27745903 )
2016
49
Diffuse alveolar hemorrhage and recombinant factor VIIa treatment in pediatric patients. ( 27186216 )
2016
50
Pulmonary Microscopic Polyangiitis Presenting as Acute Respiratory Failure from Diffuse Alveolar Hemorrhage. ( 26847106 )
2016

Variations for Diffuse Alveolar Hemorrhage

Expression for Diffuse Alveolar Hemorrhage

Search GEO for disease gene expression data for Diffuse Alveolar Hemorrhage.

Pathways for Diffuse Alveolar Hemorrhage

GO Terms for Diffuse Alveolar Hemorrhage

Biological processes related to Diffuse Alveolar Hemorrhage according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 8.96 CYP2C9 VKORC1
2 drug metabolic process GO:0017144 8.62 CYP2C9 VKORC1

Molecular functions related to Diffuse Alveolar Hemorrhage according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 8.62 CYP2C9 VKORC1

Sources for Diffuse Alveolar Hemorrhage

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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