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DISH
MCID: DFF006
MIFTS: 50

Diffuse Idiopathic Skeletal Hyperostosis (DISH)

Categories: Bone diseases, Metabolic diseases, Muscle diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Diffuse Idiopathic Skeletal Hyperostosis

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MalaCards integrated aliases for Diffuse Idiopathic Skeletal Hyperostosis:

Name: Diffuse Idiopathic Skeletal Hyperostosis 12 73 20 36 15 17
Hyperostosis, Diffuse Idiopathic Skeletal 44 70
Forestier Disease 12 20
Dish 12 20
Disseminated Idiopathic Skeletal Hyperostosis 12
Hyperostosis Diffuse Idiopathic Skeletal 54
Ankylosing Vertebral Hyperostosis 12
Dish Forestier's Disease 20
Forestier-Rotes Disease 20
Forestier's Disease 73

Classifications:

MalaCards categories:
Global: Rare diseases Metabolic diseases
Anatomical: Bone diseases Muscle diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:6652
KEGG 36 H01708
ICD9CM 34 721.6
MeSH 44 D004057
NCIt 50 C84671
SNOMED-CT 67 31487001
ICD10 32 M48.1
UMLS 70 C0020498
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Summaries for Diffuse Idiopathic Skeletal Hyperostosis

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KEGG : 36 Diffuse idiopathic skeletal hyperostosis (DISH), also known as Forestier disease, is a systemic noninflammatory disease characterized by ossification of the entheses. It affects mainly elderly men, and involves the ossification of the anterior longitudinal ligament (OALL). Although it is asymptomatic in some occasions, the disease may produce dysphagia, dysphonia, and exceptionally breathing difficulties due to airway compromise. In these cases, early surgery is recommended to alleviate airway obstruction. Although the hallmark of the DISH is considered to be the anterolateral aspect of the thoracic spine, various signs and symptoms is not limited to the spine and has often been reported to involve multiple peripheral locations as well. While the cause of DISH remains unclear, mechanical factors, genetic factors, environmental factors, drugs, and metabolic conditions have been hypothesized to be relevant. Most of the current theories focus on the pathologic OALL. There's no cure for DISH. Therapy for DISH is based on symptomatic and empiric treatment. In general, physical therapy, analgesics, antiinflammatory drugs, and muscle relaxants have been successful in managing the majority of patients with DISH.

MalaCards based summary : Diffuse Idiopathic Skeletal Hyperostosis, also known as hyperostosis, diffuse idiopathic skeletal, is related to ossification of the posterior longitudinal ligament of spine and sleep apnea. An important gene associated with Diffuse Idiopathic Skeletal Hyperostosis is COL6A1 (Collagen Type VI Alpha 1 Chain), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. The drugs Hydrogen peroxide and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and ovary, and related phenotypes are cardiovascular system and growth/size/body region

Disease Ontology : 12 A calcinosis that is the calcification or a bony hardening of ligaments in areas where they attach to your spine.

GARD : 20 Diffuse idiopathic skeletal hyperostosis (DISH) is a common skeletal disorder characterized by unusual, new bone formation. The new bone forms most often where ligaments and tendons ( connective tissues that connect bones) join bone ( entheseal area ), but there is also a generalized hardening of bones and bone overgrowth (hyperostosis). Although these changes are most often seen in the spine, DISH can affect almost any part of the skeleton, including hips, knees, ankles, feet, shoulders, hands, and ribs. Many people with DISH do not have any symptoms, but in some cases the symptoms get worse over time (progressive) and become quite severe. The most common symptoms are pain, stiffness and reduced range of motion of the neck or upper back. DISH is caused by the build up of calcium salts in the tendons and ligaments (calcification) and abnormal new bone growth (ossification) but the reason this happens is unknown. Researchers believe some combination of mechanical, genetic, environmental, and metabolic factors are involved. DISH is more common in people over 50 and in men. While there is no known cure for DISH, there are treatments that can help control symptoms.

Wikipedia : 73 Diffuse idiopathic skeletal hyperostosis (DISH) is a condition characterized by abnormal... more...

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Related Diseases for Diffuse Idiopathic Skeletal Hyperostosis

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Diseases related to Diffuse Idiopathic Skeletal Hyperostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 274)
# Related Disease Score Top Affiliating Genes
1 ossification of the posterior longitudinal ligament of spine 32.1 RSPO2 COL6A1 CCDC91 BMP4 BMP2
2 sleep apnea 31.1 INS IGF1 ALB
3 apnea, obstructive sleep 30.7 INS IGF1 ALB
4 insulin-like growth factor i 30.6 INS IGFBP3 IGF1 EGF
5 myeloma, multiple 30.2 IGF1 GAPDH FN1 FGF2 ERBB2 DKK1
6 osteoporosis 29.9 INS IGFBP3 IGF1 FGF2 EGF DKK1
7 heart disease 29.8 INS IGFBP3 IGF1 GAPDH FN1 FGF2
8 peripheral nervous system disease 29.8 INS IGF1 GAPDH FN1 FGF2 ERBB2
9 esophageal cancer 29.7 IGFBP3 IGF1 FN1 FGF2 ERBB2 EGF
10 diabetes mellitus 29.5 INS IGFBP3 IGF1 GAPDH FGF2 EGF
11 retinitis pigmentosa 29.1 INS IGF1 H2BC21 GAPDH FN1 FGF2
12 prostate cancer 29.0 INS IGFBP3 IGF1 GAPDH FN1 FGF2
13 hyperostosis 11.5
14 dysphagia 11.1
15 inflammatory spondylopathy 11.0
16 spondylitis 11.0
17 spondyloarthropathy 1 10.9
18 exostosis 10.8
19 ankylosis 10.8
20 enthesopathy 10.7
21 spondylosis 10.7
22 spinal cord injury 10.6
23 back pain 10.6
24 hyperinsulinism 10.5
25 paraplegia 10.5
26 swallowing disorders 10.5
27 spinal disease 10.5
28 quadriplegia 10.5
29 slipped capital femoral epiphysis 10.5 IGFBP3 IGF1
30 respiratory failure 10.4
31 spondyloarthropathy 10.4
32 spinal stenosis 10.4
33 hypothalamic obesity 10.4 INS IGF1
34 secondary adrenal insufficiency 10.4 INS IGFBP3 IGF1
35 subacute glomerulonephritis 10.4 ALB ACTB
36 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.4 INS IGFBP3 IGF1
37 spondylolisthesis 10.4
38 psoriatic arthritis 10.4
39 aspiration pneumonia 10.4
40 chondrocalcinosis 10.4
41 hyperuricemia 10.4
42 acromegaly 10.4
43 lipid metabolism disorder 10.4
44 degenerative disc disease 10.4
45 potter's syndrome 10.4 INS IGFBP3 IGF1
46 fetal macrosomia 10.4 INS IGFBP3 IGF1
47 acidophil adenoma 10.4 INS IGF1
48 skin tag 10.4 INS IGFBP3 IGF1
49 empty sella syndrome 10.4 INS IGFBP3 IGF1
50 hyperpituitarism 10.4 INS IGFBP3 IGF1

Graphical network of the top 20 diseases related to Diffuse Idiopathic Skeletal Hyperostosis:



Diseases related to Diffuse Idiopathic Skeletal Hyperostosis
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Symptoms & Phenotypes for Diffuse Idiopathic Skeletal Hyperostosis

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MGI Mouse Phenotypes related to Diffuse Idiopathic Skeletal Hyperostosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.27 ACTB ALB BMP2 BMP4 ERBB2 FGF2
2 growth/size/body region MP:0005378 10.25 ACTB BMP2 BMP4 COL6A1 DKK1 EGF
3 homeostasis/metabolism MP:0005376 10.21 ACTB ALB BMP2 BMP4 COL6A1 DKK1
4 embryo MP:0005380 10.09 ACTB BMP2 BMP4 DKK1 ERBB2 FN1
5 muscle MP:0005369 9.96 ACTB ALB BMP4 COL6A1 ERBB2 FGF2
6 limbs/digits/tail MP:0005371 9.92 BMP2 BMP4 DKK1 ERBB2 FN1 IGF1
7 normal MP:0002873 9.81 ACTB ALB BMP2 BMP4 EGF ERBB2
8 reproductive system MP:0005389 9.65 ACTB BMP2 BMP4 EGF ERBB2 FGF2
9 skeleton MP:0005390 9.36 BMP2 BMP4 COL6A1 DKK1 ERBB2 FGF2
Sources

Drugs & Therapeutics for Diffuse Idiopathic Skeletal Hyperostosis

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Drugs for Diffuse Idiopathic Skeletal Hyperostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrogen peroxide Approved, Vet_approved Phase 4 7722-84-1 784
2 Pharmaceutical Solutions Phase 4
3 Anti-Infective Agents, Local Phase 4
4 Anti-Infective Agents Phase 4
5
Dopamine Approved Phase 2, Phase 3 62-31-7, 51-61-6 681
6
Citalopram Approved Phase 2, Phase 3 59729-33-8 2771
7
Histamine Approved, Investigational Phase 2, Phase 3 51-45-6, 75614-87-8 774
8
Mirtazapine Approved Phase 2, Phase 3 85650-52-8, 61337-67-5 4205
9
Norepinephrine Approved Phase 2, Phase 3 51-41-2 439260
10
Sertraline Approved Phase 2, Phase 3 79617-96-2 68617
11
Aripiprazole Approved, Investigational Phase 2, Phase 3 129722-12-9 60795
12
Bupropion Approved Phase 2, Phase 3 34841-39-9, 34911-55-2 444
13
Dexetimide Withdrawn Phase 2, Phase 3 21888-98-2
14 Adrenergic alpha-Antagonists Phase 2, Phase 3
15 Psychotropic Drugs Phase 2, Phase 3
16 Dopamine Agents Phase 2, Phase 3
17 Antidepressive Agents Phase 2, Phase 3
18 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
19 Adrenergic Antagonists Phase 2, Phase 3
20 Analgesics, Opioid Phase 2, Phase 3
21 Serotonin Receptor Agonists Phase 2, Phase 3
22 Dopamine Antagonists Phase 2, Phase 3
23 Serotonin 5-HT1 Receptor Agonists Phase 2, Phase 3
24 Venlafaxine Hydrochloride Phase 2, Phase 3
25 Neurotransmitter Agents Phase 2, Phase 3
26 Serotonin 5-HT3 Receptor Antagonists Phase 2, Phase 3
27 Serotonin Uptake Inhibitors Phase 2, Phase 3
28 Serotonin and Noradrenaline Reuptake Inhibitors Phase 2, Phase 3
29 Dopamine Uptake Inhibitors Phase 2, Phase 3
30
Histamine Phosphate Phase 2, Phase 3 51-74-1 65513
31 Dopamine agonists Phase 2, Phase 3
32 Adrenergic Agents Phase 2, Phase 3
33 Analgesics Phase 2, Phase 3
34 Histamine H1 Antagonists Phase 2, Phase 3
35 Duloxetine Hydrochloride Phase 2, Phase 3
36 Histamine Antagonists Phase 2, Phase 3
37 Antipsychotic Agents Phase 2, Phase 3
38 Anti-Anxiety Agents Phase 2, Phase 3
39
Serotonin Investigational, Nutraceutical Phase 2, Phase 3 50-67-9 5202
40
Iron Approved Phase 2 7439-89-6 23925 29936
41
Deferoxamine Approved, Investigational Phase 2 70-51-9 2973
42 Chelating Agents Phase 2
43 Iron Chelating Agents Phase 2
44
acetic acid Approved 64-19-7 176
45
Streptomycin Approved, Vet_approved 57-92-1 19649
46
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
47
Nitrofurantoin Approved, Vet_approved 67-20-9 5353830
48
Ampicillin Approved, Vet_approved 69-53-4 6249
49
Trimethoprim Approved, Vet_approved 738-70-5 5578
50
Sulfamethoxazole Approved 723-46-6 5329

Interventional clinical trials:

(show top 50) (show all 72)
# Name Status NCT ID Phase Drugs
1 Prospective Randomized, Double-blind, Controlled Trial Comparing Lichtenstein's Repair of Inguinal Hernia With Polypropylene Mesh Versus Surgisis ES Soft Tissue Graft Completed NCT00614419 Phase 4
2 Evaluation of Aerosol in a Dental Clinic Not yet recruiting NCT04659928 Phase 4 Hydrogen Peroxide
3 Dietary Intervention Study for Hypertension (DISH) Completed NCT00000497 Phase 3
4 Proof of Concept Study to Treat Negative Affect in Chronic Low Back Pain Recruiting NCT04747314 Phase 2, Phase 3 Antidepressant
5 Evaluation of the Efficacy of a Novel Synthetic Bone Regeneration Material (Sil-Oss®) In the Treatment of Periodontal Intrabony Osseous Defects Completed NCT02639572 Phase 2
6 Deferoxamine In the Treatment of Aneurysmal Subarachnoid Hemorrhage (DISH) Not yet recruiting NCT04566991 Phase 2 Deferoxamine;Placebo
7 Injection of Day 2 Embryo Culture Supernatant Into the Uterine Cavity Didn't Improve Implantation and Pregnancy Rates of Day 3 Embryo Transfer: a Randomized Clinical Trial in Patients Who Underwent in Vitro Fertilization- Embryo Transfer. Completed NCT00730496 Phase 1
8 In Vitro Human Embryo Culture System Completed NCT00985218 Phase 1
9 A Comparative Study of Sibling Oocytes, Which Examines Two Sperm Selection Methods for Top Quality of Spermatozoa , Prior Intracytoplasmic Sperm Injection (ICSI) Performance, and Their Effect on Embryo Quality and IVF Outcome: A Common Selection Method Based on Morphology (ICSI) vs. a Selection Method for Mature Spermatozoa With CD44 Receptors for Hyaluronic Acid (PICSI - Physiological Selected Intracytoplasmic Sperm Injection) Unknown status NCT03240302
10 The Influence of Different Concentrations of Glucose in Culture Media(i.e: ISM1 vs. IVF) on Fertilization and Embryo Quality Unknown status NCT00606073
11 Validity, Reliability and Feasibility of an Automated Photographic Measurement/Assessment of Food Intake in the Hospitalized Elderly Unknown status NCT03650686
12 Bleach vs. Bubbles: Assessing the Impact of the Bathroom Environment on Eczema Unknown status NCT03619161
13 Randomized Controlled Comparison of Single Embryo Culture Versus Group Culture Using a Micro-well Group Culture Dish in Humans Unknown status NCT02050516
14 Multicentric Clinical Trial to Improve Blastocyst Utilisation Rate (in Relation to 2 PN Embryos) by Group Culture of Human Embryos in WOW Dishes. Unknown status NCT02010424
15 A Comparative Study Between Autologous Non Cultured Epidermal Cell Suspension Versus Combination of Autologous Non Cultured Epidermal Cell Suspension and Non Cultured Dermal Cell Suspension in Stable Vitiligo Unknown status NCT03013049
16 What is the Best Sperm Source and Way of Sperm Selection in Cases With Abnormal Static Oxidation Reduction Potential (sORP) Levels on the Day of ICSI? Unknown status NCT03360526
17 A Migration (RSA) and Bone Density (DEXA) Study Comparing Hi-Fatigue Bone Cement and Palacos Bone Cement in Fixation of a Smooth vs. a Fine-blasted Femoral Stem. A Prospective Randomized Study on Primary Total Hip Arthroplasty. Unknown status NCT01289834
18 Clinical Study Randomized of the Effects of the Administered Time of Meal on the Treatment of Overweight and Obesity Unknown status NCT03347942
19 Effectiveness of the Carbohydrate Counting Method on Postprandial Glucose Concentrations After Consumption of Mixed Meals in Adults With Type 1 Diabetes Completed NCT02928016
20 The Effect of Culture Media Microdroplet Geometry and Different Oil Overlay on Pre Implantation Embryonic Development in Dry Incubators: Prospective Randomized Study. Completed NCT04485806
21 Does Blueberry Intake Alleviate Postprandial Lipemia-induced Inflammation? Completed NCT01594008
22 Reducing Antibiotic Resistance: Improved Diagnostics and Treatment for Uncomplicated Urinary Tract Infection in General Practice, Denmark Completed NCT02323087
23 Research Study to Evaluate Capacitation Culture (CAPA) Followed by in Vitro Maturation (IVM) of Human Oocytes: A Randomized Pilot Study Completed NCT03921710 CAPA-IVM;Standard-IVM
24 A Randomized Crossover Trial to Compare the Changes of Postprandial Oxidative Stress After Consumption of Meals From Different Cultures in Healthy Chinese Adults Completed NCT02006771
25 The Effect of Potatoes on Markers of Cardiometabolic Health Completed NCT03495284
26 Topical Application of Silver Nanoparticles Reduced Oral Pathogens in Mechanically Ventilated Patients: A Randomized Controlled Clinical Trial Completed NCT02761525
27 Pilot Study of the Effect of Purple Rice on Glucose Tolerance, Serum Lipids and Inflammation. Completed NCT01720511
28 Optimal Dietary Treatment of Obese Adults Completed NCT01685957
29 DISH Data Analysis Study Completed NCT00005464
30 Effectiveness of the Use of the PICSI Dish (Hyaluronan Microdot) in the Selection of Sperm for Intracytoplasmic Sperm Injection (ICSI) for Patients Having a Low Versus High Proportion of Hyaluronan Binding Sperm (HBA) Completed NCT00741494
31 Eeva 12-well Dish Study Completed NCT01635036
32 The Effects of Potatoes and Other Carbohydrate Side Dishes Consumed With Meat on Food Intake, Glycaemia and Satiety Response in Children Completed NCT02499107
33 Does the Access to Small Delicious Dishes, 24 Hours a Day, Have a Positive Effect on Nutritional Intake in Patients at Nutritional Risk? Completed NCT01322087
34 Use of Team-Based Goals and Incentives to Improve the Performance of Community-Based Health Workers in Promoting Reproductive, Maternal, Newborn and Child Health and Nutrition Behaviors in Bihar, India: A Cluster Randomized Trial Completed NCT03561012
35 Effect of Sperm Selection Techniques on Human Neonatal Gender Ratio in Patients Undergoing ICSI Completed NCT03922568
36 Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) Benefits in the Presence of Advanced Maternal Age: a Prospective Randomized Study Completed NCT01620346
37 Evaluating the Impact of Behavioral Nudges on Student Independent Hand-washing Practices in Elementary Schools in the Philippines Completed NCT04244799
38 Evaluating the Impact on Lunch Sales and Consumption of New School Lunch Guidelines and Behavioral Interventions in NYC Schools Completed NCT02091154
39 PICSI vs. MACS for Abnormal Sperm DNA Fragmentation ICSI Cases: a Prospective Randomized Trial Completed NCT03398317
40 Does Substitution of Meat Products With White Button Mushrooms Have Potential for Weight Reduction? Studies of the Level of Short and Intermediate-term Caloric Compensation, Satiety, and Dietary Satisfaction Among Lean and Obese Men and Women. Completed NCT00198770
41 Partnering for Prevention: Building Healthy Habits in Underserved Communities Completed NCT03559907
42 The Psychobiological Effects of a One-Month Insight Meditation Retreat, a Sub-study of The Shamatha Project: A Longitudinal, Randomized Waitlist Control Study of Cognitive, Emotional, and Neural Effects of Intensive Meditation Training Completed NCT03056105
43 Combined Robot-assisted Upper Limb Training and Botulinum Toxin Treatment for Upper Limb Function and Spasticity: a Randomized Controlled Single-blinded Trial in 32 Chronic Stroke Patients. Completed NCT03590314
44 Effectiveness of Differing Levels of Support for Family Mealtimes on Obesity Prevention Among Head Start Preschoolers Completed NCT02487251
45 Self-regulated Constraint-induced Movement Therapy in Subacute Stroke Patients Completed NCT02480140
46 Does the Addition of Virtual Reality Training to a Standard Program of Inpatient Rehabilitation Improve Sitting Balance Ability and Function After Stroke? A Blinded Randomized Controlled Trial. Completed NCT02285933
47 Reproductive Outcomes of Different Sperm Selection Techniques; Density Gradient Centrifugation, Testicular Sperm, PICSI, and MACS for ICSI Patients With Abnormal Sperm DNA Fragmentation Completed NCT04482517
48 Community Based Management of Severe Malnutrition in Under 5 Children in Tribal Area of Melghat, Maharashtra- Cluster Randomized Control Field Trial Completed NCT02671786
49 Positive Effect of Fortified Hospital Food on Nutritional Intake in Patients at Nutritional Risk. A Randomized Controlled Trial. Completed NCT01415635
50 The Efficacy of Front-of-package Labelling Schemes: an Experimental Study Completed NCT03290118

Search NIH Clinical Center for Diffuse Idiopathic Skeletal Hyperostosis

Cochrane evidence based reviews: hyperostosis, diffuse idiopathic skeletal

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Genetic Tests for Diffuse Idiopathic Skeletal Hyperostosis

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Anatomical Context for Diffuse Idiopathic Skeletal Hyperostosis

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MalaCards organs/tissues related to Diffuse Idiopathic Skeletal Hyperostosis:

40
Bone, Spinal Cord, Ovary, Prostate
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Publications for Diffuse Idiopathic Skeletal Hyperostosis

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Articles related to Diffuse Idiopathic Skeletal Hyperostosis:

(show top 50) (show all 882)
# Title Authors PMID Year
1
Is diffuse idiopathic skeletal hyperostosis a disease or a syndrome? 61 20
28013194 2017
2
Diffuse idiopathic skeletal hyperostosis: Diagnostic, clinical, and paleopathological considerations. 20 61
27004482 2016
3
Retinoid and bone metabolic marker in ossification of the posterior longitudinal ligament. 54 61
9706481 1998
4
Ossification of the posterior longitudinal ligament, diffuse, idiopathic skeletal hyperostosis, abnormal retinol and retinol binding protein: a familial observation. 54 61
7562783 1995
5
Jacques Forestier: Forgotten Contributions of a Rheumatologist to Spine Surgery. 61
33444823 2021
6
Idiopathic dorsal spinal cord herniation perforating the lamina: a case report and review of the literature. 61
33745029 2021
7
Diffuse idiopathic skeletal hyperostosis in elderly Icelanders and its association with the metabolic syndrome: the AGES-Reykjavik Study. 61
33682605 2021
8
Two Cases of Severe Type 2 Respiratory Failure Associated with Diffuse Idiopathic Skeletal Hyperostosis. 61
33550773 2021
9
An Unrecognized Ligament and its Ossification in the Craniocervical Junction: Prevalence, Patient Characteristics, and Anatomic Evidence. 61
33739308 2021
10
A Scoring System for Anterior Longitudinal Ligament Ossification of the Lumbar Spine in Diffuse Idiopathic Skeletal Hyperostosis: Relationship Between the Extent of Ligament Ossification and the Range of Motion. 61
33655763 2021
11
Surgical Treatment of Diffuse Idiopathic Skeletal Hyperostosis (DISH) Involving the Cervical Spine: Technical Nuances and Outcome of a Multicenter Experience. 61
33590802 2021
12
Diffuse Idiopathic Skeletal Hyperostosis (DISH) in Type 2 Diabetes: A New Imaging Possibility and a New Biomarker. 61
33047242 2021
13
Ossification of Posterior Longitudinal Ligament in Cervical Spine and Its Association With Ossified Lesions in the Whole Spine: A Cross-Sectional Study of 2500 CT Scans. 61
33567929 2021
14
Diffuse idiopathic skeletal hyperostosis: A potential factor in the induction of thoracic spondylotic myelopathy. 61
32063469 2021
15
Post-traumatic spinal hematoma in ankylosing spondylitis. 61
33452963 2021
16
Sagittal Deformity Correction in a Patient Suffering From Diffuse Idiopathic Skeletal Hyperostosis Who Previously Underwent a Total Hip and Bilateral Knee Replacement. 61
33628612 2021
17
Esophageal incarceration associated with cervical vertebral fracture in a patient with diffuse idiopathic skeletal hyperostosis. 61
29935973 2021
18
Diffuse Idiopathic Skeletal Hyperostosis induced Oropharyngeal Dysphagia. 61
33140270 2021
19
Pathomechanism and prevention of further surgery after posterior decompression for lumbar spinal canal stenosis in patients with diffuse idiopathic skeletal hyperostosis. 61
33453385 2021
20
A rare case of an unexpected difficult airway management in a diffuse idiopathic skeletal hyperostosis patient and post-operative airway evaluation with 3D printing technique. 61
33553368 2021
21
Comparative analysis of clinical factors associated with pedicle screw pull-out during or immediately after surgery between intraoperative cone-beam computed tomography and postoperative computed tomography. 61
33422036 2021
22
Thoracic spondylotic myelopathy presumably caused by diffuse idiopathic skeletal hyperostosis in a patient who underwent decompression and percutaneous pedicle screw fixation. 61
33628446 2021
23
Diffuse Idiopathic Skeletal Hyperostosis (DISH) and a Possible Inflammatory Component. 61
33496875 2021
24
Risk Factors Affecting Cage Retropulsion into the Spinal Canal Following Posterior Lumbar Interbody Fusion: Association with Diffuse Idiopathic Skeletal Hyperostosis. 61
33371621 2020
25
Heterotopic ossification in a patient with diffuse idiopathic skeletal hyperostosis: Input from histological findings. 61
33272008 2020
26
Activities of Daily Living after Surgical Treatment for Osteoporotic Vertebral Fracture with or without Diffuse Idiopathic Skeletal Hyperostosis: A Retrospective Single-Institutional Study. 61
32460468 2020
27
Risk factors for delayed diagnosis of spinal fracture associated with diffuse idiopathic skeletal hyperostosis: A nationwide multiinstitution survey. 61
33334624 2020
28
Differences in Bone Mineral Density and Bone Turnover Markers Between Subjects With and Without Diffuse Idiopathic Skeletal Hyperostosis. 61
32925682 2020
29
An Analysis of Patient and Fracture Characteristics and Clinical Outcomes in Patients With Hyperostotic Spine Fractures. 61
32875832 2020
30
A systematic review of surgical procedures on thoracic myelopathy. 61
33302988 2020
31
Diffuse idiopathic skeletal hyperostosis (DISH) with ossification of the posterior longitudinal ligament (OPLL) in the cervical spine without neurological deficit - A Case report. 61
33251005 2020
32
[Spinal Disorders in the Oldest-Old]. 61
33293467 2020
33
Trabecular bone score and bone turnover markers in men with DISH: Data from the Camargo Cohort study. 61
32093967 2020
34
Musculoskeletal manifestations among diabetic patients in Saudi Arabia. 61
33532401 2020
35
The relationship of diffuse idiopathic skeletal hyperostosis, visceral fat accumulation, and other age-related diseases with the prevalent vertebral fractures in elderly men with castration-naïve prostate cancer. 61
33191830 2020
36
Cervical Myelopathy and Lumbar Spondylolisthesis in Elderly Patients with Diffuse Idiopathic Skeletal Hyperostosis (DISH) - A Case Series. 61
33708711 2020
37
Atypical Occipitocervical Dissociation Associated with Ossification of the Posterior Longitudinal Ligament and Diffuse Idiopathic Skeletal Hyperostosis in Low-Energy Trauma. 61
33708701 2020
38
Minimally Invasive versus Conventional Open Surgery for Fixation of Spinal Fracture in Ankylosed Spine. 61
33403059 2020
39
Forestier Rotes-Querol disease (diffuse idiopathic skeletal hyperostosis). 61
32067702 2020
40
DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS IN CAPTIVE GORILLAS (GORILLA SPP.): APPEARANCES AND DIAGNOSIS. 61
33480533 2020
41
Timing of Surgical Intervention for Dysphagia in Patients With Diffuse Idiopathic Skeletal Hyperostosis: A Systematic Review and Meta-Analysis. 61
33239502 2020
42
Combined Anterior Osteophytectomy and Cricopharyngeal Myotomy for Treatment of DISH-Associated Dysphagia. 61
33203249 2020
43
Metabolic Syndrome is a Predisposing Factor for Diffuse Idiopathic Skeletal Hyperostosis. 61
33211945 2020
44
Relationship between diffuse idiopathic skeletal hyperostosis and fragility vertebral fracture: a prospective study in older men. 61
33200181 2020
45
Diffuse Idiopathic Skeletal Hyperostosis in a Young Woman Treated With Isotretinoin. 61
33139176 2020
46
Whole Spine CT Scan for the Detection of Acute Spinal Fractures in Diffuse Idiopathic Skeletal Hyperostosis Patients Who Sustained Low-energy Trauma. 61
32341308 2020
47
Diffuse Idiopathic Skeletal Hyperostosis With Peripheral Joint Involvement. 61
31295154 2020
48
Spinal trauma in DISH and AS: is MRI essential following the detection of vertebral fractures on CT? 61
33130303 2020
49
Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case report. 61
33100075 2020
50
Design of primers for direct sequencing of nine coding exons in the human ACVR1 gene. 61
32512165 2020
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Variations for Diffuse Idiopathic Skeletal Hyperostosis

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Expression for Diffuse Idiopathic Skeletal Hyperostosis

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Search GEO for disease gene expression data for Diffuse Idiopathic Skeletal Hyperostosis.
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Pathways for Diffuse Idiopathic Skeletal Hyperostosis

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Pathways related to Diffuse Idiopathic Skeletal Hyperostosis according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Signaling by GPCR 65
Show member pathways
 14.1 SPC25 RSPO2 INS IGF1 H2BC21 FN1
2
ERK Signaling 63
Show member pathways
 13.77 IGF1 FN1 FGF2 ERBB2 EGF COL6A1
3
Developmental Biology 65
Show member pathways
 13.43 INS H2BC21 FN1 FGF2 ERBB2 EGF
4
Akt Signaling 63
Show member pathways
 13.35 IGF1 FGF2 ERBB2 EGF BMP4 BMP2
5
PAK Pathway 63
Show member pathways
 13.23 MAPRE3 IGF1 FGF2 ERBB2 EGF BMP4
6
Nanog in Mammalian ESC Pluripotency 63
Show member pathways
 13.19 IGF1 FGF2 ERBB2 EGF BMP4 BMP2
7
p70S6K Signaling 63
Show member pathways
 12.98 INS IGF1 FGF2 EGF BMP4 BMP2
8
Phospholipase-C Pathway 63
Show member pathways
 12.97 IGF1 FN1 FGF2 EGF COL6A1 BMP4
9
PI3K-Akt signaling pathway 36
Show member pathways
 12.93 INS IGF1 FN1 FGF2 ERBB2 EGF
10
Focal Adhesion 36 1
Show member pathways
 12.82 IGF1 FN1 ERBB2 EGF COL6A1 ACTB
11
Pathways in cancer 36
12.76 IGF1 FN1 FGF2 ERBB2 EGF BMP4
12
MAPK signaling pathway 36 1
12.71 INS IGF1 FGF2 ERBB2 EGF
13
Gastric cancer 36
Show member pathways
 12.7 IGF1 FGF2 ERBB2 EGF ACTB
14
Degradation of the extracellular matrix 65
Show member pathways
 12.68 FN1 FGF2 COL6A1 BMP4 BMP2
15
Ras signaling pathway 36
Show member pathways
 12.67 INS IGF1 FGF2 EGF ACTB
16
NF-KappaB Family Pathway 63
Show member pathways
 12.62 IGF1 FGF2 EGF BMP4 BMP2
17
Regulation of actin cytoskeleton 1 36
12.55 INS FN1 FGF2 EGF ACTB
18
Human Embryonic Stem Cell Pluripotency 63
Show member pathways
 12.4 FGF2 DKK1 BMP4 BMP2
19
G-protein signaling RAC1 in cellular process 23
Show member pathways
 12.3 IGF1 FGF2 ERBB2 EGF BMP4 BMP2
20
Translation Non-genomic (rapid) action of Androgen Receptor 23
Show member pathways
 12.25 IGF1 ERBB2 EGF BMP4 BMP2
21
Proteoglycans in cancer 36
12.23 IGF1 FN1 FGF2 ERBB2 ACTB
22
Adipogenesis 1
11.99 INS IGF1 BMP4 BMP2
23
HIF-1 signaling pathway 36
11.87 INS IGF1 GAPDH ERBB2 EGF
24
Senescence and Autophagy in Cancer 1
11.83 INS IGFBP3 IGF1 FN1 BMP2
25
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.82 INS IGF1 FGF2 EGF DKK1 BMP4
26
G-protein signaling_RhoA regulation pathway 23
11.68 IGF1 FGF2 ERBB2 EGF BMP4 BMP2
27
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.62 IGF1 FGF2 EGF BMP4 BMP2
28
Lung fibrosis 1
11.59 IGF1 FGF2 EGF
29
Cardiac Progenitor Differentiation 1
11.38 INS IGF1 FGF2 DKK1 BMP4
30
Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.2 INS IGFBP3 IGF1 FN1 FGF2 EGF
31
Differentiation Pathway 1
11.11 INS IGF1 FGF2 EGF DKK1 BMP4
32
G-protein signaling_Rap2B regulation pathway 23
10.87 IGF1 FN1 FGF2 ERBB2 EGF COL6A1
33
BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation 1
10.76 DKK1 BMP2
Sources

GO Terms for Diffuse Idiopathic Skeletal Hyperostosis

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Cellular components related to Diffuse Idiopathic Skeletal Hyperostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 RSPO2 INS IGFBP3 IGF1 FN1 FGF2
2 endoplasmic reticulum lumen GO:0005788 9.63 INS IGFBP3 FN1 COL6A1 BMP4 ALB
3 platelet alpha granule lumen GO:0031093 9.56 IGF1 FN1 EGF ALB
4 extracellular space GO:0005615 9.44 INS IGFBP3 IGF1 H2BC21 FN1 FGF2
5 insulin-like growth factor ternary complex GO:0042567 9.37 IGFBP3 IGF1
6 insulin-like growth factor binding protein complex GO:0016942 9.32 IGFBP3 IGF1

Biological processes related to Diffuse Idiopathic Skeletal Hyperostosis according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.1 MAPRE3 IGF1 FGF2 EGF BMP4 BMP2
2 angiogenesis GO:0001525 9.97 FN1 FGF2 EGF BMP4
3 heart development GO:0007507 9.97 FN1 ERBB2 BMP4 BMP2
4 positive regulation of protein phosphorylation GO:0001934 9.95 FGF2 ERBB2 BMP4 BMP2
5 positive regulation of cell proliferation GO:0008284 9.95 INS IGF1 FN1 FGF2 ERBB2 EGF
6 positive regulation of protein kinase B signaling GO:0051897 9.92 INS FGF2 ERBB2 EGF
7 positive regulation of cell migration GO:0030335 9.89 INS IGF1 EGF BMP4 BMP2
8 positive regulation of osteoblast differentiation GO:0045669 9.84 IGF1 BMP4 BMP2
9 activation of MAPK activity GO:0000187 9.84 IGF1 FGF2 EGF BMP2
10 positive regulation of endothelial cell migration GO:0010595 9.83 FGF2 EGF BMP4
11 cellular response to growth factor stimulus GO:0071363 9.83 ERBB2 BMP4 BMP2
12 platelet degranulation GO:0002576 9.83 IGF1 FN1 EGF ALB
13 positive regulation of MAP kinase activity GO:0043406 9.81 FGF2 ERBB2 EGF
14 positive regulation of cell differentiation GO:0045597 9.77 INS BMP4 BMP2
15 osteoblast differentiation GO:0001649 9.77 RSPO2 IGFBP3 COL6A1 BMP4 BMP2
16 positive regulation of endothelial cell proliferation GO:0001938 9.76 FGF2 EGF BMP4 BMP2
17 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.75 FGF2 BMP4 BMP2
18 branching involved in ureteric bud morphogenesis GO:0001658 9.74 FGF2 BMP4 BMP2
19 positive regulation of epithelial cell proliferation GO:0050679 9.73 IGF1 FGF2 ERBB2 BMP4
20 cellular protein metabolic process GO:0044267 9.73 INS IGFBP3 IGF1 FN1 BMP4 ALB
21 wound healing GO:0042060 9.72 INS IGF1 FN1 FGF2 ERBB2
22 positive regulation of mitotic nuclear division GO:0045840 9.69 INS IGF1 EGF
23 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.68 IGFBP3 IGF1
24 negative regulation of cardiac muscle cell differentiation GO:2000726 9.67 DKK1 BMP2
25 regulation of transmembrane transporter activity GO:0022898 9.65 INS ACTB
26 bone mineralization involved in bone maturation GO:0035630 9.64 IGF1 BMP2
27 telencephalon regionalization GO:0021978 9.64 BMP4 BMP2
28 negative regulation of ERBB signaling pathway GO:1901185 9.62 ERBB2 EGF
29 BMP signaling pathway involved in heart development GO:0061312 9.61 BMP4 BMP2
30 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.61 BMP4 BMP2
31 positive regulation of gene expression GO:0010628 9.61 INS IGF1 FN1 FGF2 ERBB2 EGF
32 negative regulation of immature T cell proliferation in thymus GO:0033088 9.6 ERBB2 BMP4
33 positive regulation of epithelial tube formation GO:1905278 9.58 FGF2 EGF
34 mesenchymal cell proliferation involved in ureteric bud development GO:0072138 9.56 BMP4 BMP2
35 BMP signaling pathway involved in heart induction GO:0003130 9.55 BMP4 BMP2
36 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.55 INS IGF1 FN1 FGF2 EGF
37 cardiac jelly development GO:1905072 9.48 BMP4 BMP2
38 positive regulation of MAPK cascade GO:0043410 9.17 INS IGFBP3 IGF1 FGF2 ERBB2 EGF

Molecular functions related to Diffuse Idiopathic Skeletal Hyperostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.81 MAPRE3 INS GAPDH FN1 FGF2 ERBB2
2 heparin binding GO:0008201 9.56 RSPO2 FN1 FGF2 BMP4
3 BMP receptor binding GO:0070700 9.32 BMP4 BMP2
4 co-receptor binding GO:0039706 9.13 DKK1 BMP4 BMP2
5 growth factor activity GO:0008083 9.1 IGF1 FGF2 EGF DKK1 BMP4 BMP2
Sources

Sources for Diffuse Idiopathic Skeletal Hyperostosis

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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