MCID: DFF006
MIFTS: 41

Diffuse Idiopathic Skeletal Hyperostosis

Categories: Rare diseases, Metabolic diseases, Bone diseases

Aliases & Classifications for Diffuse Idiopathic Skeletal Hyperostosis

MalaCards integrated aliases for Diffuse Idiopathic Skeletal Hyperostosis:

Name: Diffuse Idiopathic Skeletal Hyperostosis 12 76 53 37 15
Hyperostosis, Diffuse Idiopathic Skeletal 44 73
Forestier Disease 12 53
Dish 12 53
Disseminated Idiopathic Skeletal Hyperostosis 12
Hyperostosis Diffuse Idiopathic Skeletal 55
Ankylosing Vertebral Hyperostosis 12
Dish Forestier's Disease 53
Forestier-Rotes Disease 53
Forestier's Disease 76

Classifications:



External Ids:

Disease Ontology 12 DOID:6652
ICD10 33 M48.1
ICD9CM 35 721.6
MeSH 44 D004057
NCIt 50 C84671
SNOMED-CT 68 31487001 55815007
KEGG 37 H01708
UMLS 73 C0020498

Summaries for Diffuse Idiopathic Skeletal Hyperostosis

NIH Rare Diseases : 53 Diffuse idiopathic skeletal hyperostosis (DISH) is a common skeletal disorder characterised by unusual, new bone formation. The new bone forms most often where ligaments and tendons (connective tissues that connect bones) join bone (entheseal area), but there is also a generalized hardening of bones and bone overgrowth (hyperostosis). Although these changes are most often seen in the spine, DISH can affect almost any part of the skeleton, including hips, knees, ankles, feet, shoulders, hands, and ribs. Many people with DISH do not have any symptoms, but in some cases the symptoms get worse over time (progressive) and become quite severe. The most common symptoms are pain, stiffness and reduced range of motion of the neck or upper back. DISH is caused by the build up of calcium salts in the tendons and ligaments (calcification) and abnormal new bone growth (ossification) but the reason this happens is unknown.  Researchers believe some combination of mechanical, genetic, environmental, and metabolic factors are involved. DISH is more common in people over 50 and in men. While there is no known cure for DISH, there are treatments that can help control symptoms.

MalaCards based summary : Diffuse Idiopathic Skeletal Hyperostosis, also known as hyperostosis, diffuse idiopathic skeletal, is related to insulin-like growth factor i and acromegaly. An important gene associated with Diffuse Idiopathic Skeletal Hyperostosis is IGF1 (Insulin Like Growth Factor 1), and among its related pathways/superpathways are Senescence and Autophagy in Cancer and Endochondral Ossification. The drugs insulin and Insulin, Globin Zinc have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and lung, and related phenotypes are limbs/digits/tail and muscle

Disease Ontology : 12 A calcinosis that is the calcification or a bony hardening of ligaments in areas where they attach to your spine.

Wikipedia : 76 Diffuse idiopathic skeletal hyperostosis (DISH) is a condition characterized by abnormal... more...

Related Diseases for Diffuse Idiopathic Skeletal Hyperostosis

Diseases related to Diffuse Idiopathic Skeletal Hyperostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 insulin-like growth factor i 30.1 IGF1 IGFBP3
2 acromegaly 30.0 IGF1 IGFBP3
3 osteoporosis 28.8 IGF1 IGFBP3 MGP
4 ankylosing vertebral hyperostosis with tylosis 11.2
5 ossification of the posterior longitudinal ligament of spine 11.2
6 hyperostosis 11.2
7 dysphagia 10.7
8 cervicitis 10.7
9 spondyloarthropathy 1 10.6
10 spondylitis 10.6
11 slipped capital femoral epiphysis 10.4 IGF1 IGFBP3
12 secondary adrenal insufficiency 10.4 IGF1 IGFBP3
13 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.4 IGF1 IGFBP3
14 pituitary adenoma 1, multiple types 10.4 IGF1 IGFBP3
15 central precocious puberty 10.4 IGF1 IGFBP3
16 mammographic density 10.4 IGF1 IGFBP3
17 hyperpituitarism 10.4 IGF1 IGFBP3
18 isolated growth hormone deficiency, type ib 10.4 IGF1 IGFBP3
19 acid-labile subunit deficiency 10.4 IGF1 IGFBP3
20 fetal macrosomia 10.3 IGF1 IGFBP3
21 laron syndrome 10.3 IGF1 IGFBP3
22 growth hormone deficiency 10.3 IGF1 IGFBP3
23 osteogenesis imperfecta, type i 10.3 IGF1 IGFBP3
24 exudative vitreoretinopathy 1 10.3 IGF1 IGFBP3
25 colorectal adenoma 10.3 IGF1 IGFBP3
26 male reproductive organ cancer 10.3 IGF1 IGFBP3
27 spondylosis 10.2
28 hypopituitarism 10.2 IGF1 IGFBP3
29 turner syndrome 10.2 IGF1 IGFBP3
30 arthritis 10.2
31 diabetes mellitus 10.2
32 pseudoarthrosis 10.2
33 esophagitis 10.2
34 enthesopathy 10.2
35 back pain 10.2
36 breast disease 10.2 IGF1 IGFBP3
37 osteoarthritis 10.1
38 spinal stenosis 10.1
39 laryngitis 10.1
40 paraplegia 10.1
41 silver-russell syndrome 10.1 IGF1 IGFBP3
42 apnea, obstructive sleep 10.0
43 rheumatoid arthritis 10.0
44 myeloma, multiple 10.0
45 psoriatic arthritis 10.0
46 spinal cord injury 10.0
47 aspiration pneumonia 10.0
48 sleep apnea 10.0
49 mucositis 10.0
50 chondrocalcinosis 10.0

Graphical network of the top 20 diseases related to Diffuse Idiopathic Skeletal Hyperostosis:



Diseases related to Diffuse Idiopathic Skeletal Hyperostosis

Symptoms & Phenotypes for Diffuse Idiopathic Skeletal Hyperostosis

MGI Mouse Phenotypes related to Diffuse Idiopathic Skeletal Hyperostosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.26 CYP26C1 IGF1 IGFBP3 SLC29A1
2 muscle MP:0005369 8.92 COL6A1 IGF1 IGFBP3 MGP

Drugs & Therapeutics for Diffuse Idiopathic Skeletal Hyperostosis

Drugs for Diffuse Idiopathic Skeletal Hyperostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 insulin Not Applicable
2 Insulin, Globin Zinc Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Magnetic Resonance Imaging in High Risk Patients for the Development of Diffuse Idiopathic Skeletal Hyperostosis (DISH) Not yet recruiting NCT03237455 Not Applicable

Search NIH Clinical Center for Diffuse Idiopathic Skeletal Hyperostosis

Cochrane evidence based reviews: hyperostosis, diffuse idiopathic skeletal

Genetic Tests for Diffuse Idiopathic Skeletal Hyperostosis

Anatomical Context for Diffuse Idiopathic Skeletal Hyperostosis

MalaCards organs/tissues related to Diffuse Idiopathic Skeletal Hyperostosis:

41
Bone, Spinal Cord, Lung, Testes

Publications for Diffuse Idiopathic Skeletal Hyperostosis

Articles related to Diffuse Idiopathic Skeletal Hyperostosis:

(show top 50) (show all 381)
# Title Authors Year
1
Thoracic aortic aneurysm is an independent factor associated with diffuse idiopathic skeletal hyperostosis. ( 29701101 )
2018
2
The Natural Course of Diffuse Idiopathic Skeletal Hyperostosis in the Thoracic Spine of Adult Males. ( 29657149 )
2018
3
Regional differences in diffuse idiopathic skeletal hyperostosis: a retrospective cohort study from Sweden and Japan. ( 29916957 )
2018
4
Simultaneous Bilateral Quadriceps Tendon Rupture in a Patient with Diffuse Idiopathic Skeletal Hyperostosis after Minimal Trauma: Eight-Year Follow-Up. ( 29682378 )
2018
5
Anterior longitudinal ligament in diffuse idiopathic skeletal hyperostosis: Ossified or displaced? ( 29667228 )
2018
6
Prevalence of diffuse idiopathic skeletal hyperostosis (DISH) assessed with whole-spine computed tomography in 1479 subjects. ( 29848322 )
2018
7
The surgical management of dysphagia secondary to diffuse idiopathic skeletal hyperostosis. ( 29438856 )
2018
8
L5-S1 Charcot spine induced by diffuse idiopathic skeletal hyperostosis in chronic tetraplegia: 2 cases. ( 29920334 )
2018
9
Rich table but short life: Diffuse idiopathic skeletal hyperostosis in Danish astronomer Tycho Brahe (1546-1601) and its possible consequences. ( 29672561 )
2018
10
Esophageal incarceration associated with cervical vertebral fracture in a patient with diffuse idiopathic skeletal hyperostosis. ( 29935973 )
2018
11
Diffuse Idiopathic Skeletal Hyperostosis-On the Wrong Side? ( 29481728 )
2018
12
Severe hip joint motion restriction in a patient with diffuse idiopathic skeletal hyperostosis: A case report. ( 29718882 )
2018
13
Degenerative changes of the thoracic spine do exist in patients with diffuse idiopathic skeletal hyperostosis: a detailed thoracic spine CT analysis. ( 29482347 )
2018
14
Traumatic spondyloptosis at the thoracolumbar junction in a patient with diffuse idiopathic skeletal hyperostosis: A case report. ( 29478625 )
2018
15
Diffuse idiopathic skeletal hyperostosis is associated with lumbar spinal stenosis requiring surgery. ( 29327302 )
2018
16
Factors associated with bone metabolism in patients with cervical ossification of the posterior longitudinal ligament accompanied with diffuse idiopathic skeletal hyperostosis. ( 29547116 )
2018
17
Diffuse Idiopathic Skeletal Hyperostosis Extended to the Lumbar Segment is a Risk Factor of Reoperation in Patients Treated Surgically for Lumbar Stenosis. ( 29481381 )
2018
18
Bone mineral density changes over time in diffuse idiopathic skeletal hyperostosis of the thoracic spine. ( 29649655 )
2018
19
Prevalence of Diffuse Idiopathic Skeletal Hyperostosis Diagnosed by Whole Spine Computed Tomography: A Preliminary Study. ( 29564046 )
2018
20
Thoracic spondylolisthesis and spinal cord compression in diffuse idiopathic skeletal hyperostosis: a case report. ( 28363281 )
2017
21
A rare association of dysphagia and cervical compressive myelopathy in diffuse idiopathic skeletal hyperostosis. ( 28084279 )
2017
22
Correction: Diffuse idiopathic skeletal hyperostosis (DISH): where we are now and where to go next. ( 29177083 )
2017
23
Odontoid Fracture in a Patient With Diffuse Idiopathic Skeletal Hyperostosis. ( 28255505 )
2017
24
Diffuse Idiopathic Skeletal Hyperostosis Involving Cervical and Lumbar Spine Presenting with Dysphagia: A Case Report. ( 28819624 )
2017
25
Cervical diffuse idiopathic skeletal hyperostosis (DISH) causing oropharyngeal dysphagia. ( 28314808 )
2017
26
Diffuse idiopathic skeletal hyperostosis (DISH): where we are now and where to go next. ( 28955488 )
2017
27
Spinal fracture in diffuse idiopathic skeletal hyperostosis. ( 28986210 )
2017
28
Magnetic resonance imaging in diffuse idiopathic skeletal hyperostosis: similarities to axial spondyloarthritis. ( 28364275 )
2017
29
Prevalence of thoracic diffuse idiopathic skeletal hyperostosis (DISH) in Japanese: Results of chest CT-based cross-sectional study. ( 27697426 )
2017
30
A rare case of Eagle syndrome and diffuse idiopathic skeletal hyperostosis in the cervical spine. ( 28928500 )
2017
31
Swallowing disorders among patients with diffuse idiopathic skeletal hyperostosis. ( 28084872 )
2017
32
Diffuse idiopathic skeletal hyperostosis causing L4 and L5 nerve root entrapment. ( 28941276 )
2017
33
Spinal Epidural Hematoma Related to Vertebral Fracture in an Atypical Rigid Diffuse Idiopathic Skeletal Hyperostosis: A Case Report. ( 28255506 )
2017
34
Relationship between diffuse idiopathic skeletal hyperostosis, abdominal aortic calcification and associated metabolic disorders: Data from the Camargo Cohort. ( 28283270 )
2017
35
Styloid Process Elongation on Cervical Spine Computed Tomography is Associated with the Enthesopathy-Related Diseases of Ankylosing Spondylitis and Diffuse Idiopathic Skeletal Hyperostosis. ( 29185278 )
2017
36
Diffuse idiopathic skeletal hyperostosis with cervical myelopathy. ( 28385821 )
2017
37
Diffuse idiopathic skeletal hyperostosis: Can we identify a peripheral pattern? ( 28528871 )
2017
38
Diffuse idiopathic skeletal hyperostosis (DISH): Increased prevalence in Pacific Islanders. ( 29024571 )
2017
39
Diffuse Idiopathic Skeletal Hyperostosis (DISH) and Impaired Physical Function: The Rancho Bernardo Study. ( 28369706 )
2017
40
Diffuse Idiopathic Skeletal Hyperostosis: Persistent Sore Throat and Dysphagia in an Elderly Smoker Male. ( 29062363 )
2017
41
Diffuse Idiopathic Skeletal Hyperostosis (DISH) as a Cause of Failure Following Distal Clavicle Excision A Case Report and Review of the Literature. ( 29151015 )
2017
42
Morphological characteristics of diffuse idiopathic skeletal hyperostosis in the cervical spine. ( 29155874 )
2017
43
Imaging findings suggestive of axial spondyloarthritis in diffuse idiopathic skeletal hyperostosis. ( 28371491 )
2017
44
Prevalence of Diffuse Idiopathic Skeletal Hyperostosis in Patients with Spinal Disorders. ( 28243371 )
2017
45
CT Abnormalities in the Sacroiliac Joints of Patients With Diffuse Idiopathic Skeletal Hyperostosis. ( 28125786 )
2017
46
Delayed leg paraplegia associated with hyperextension injury in patients with diffuse idiopathic skeletal hyperostosis (DISH): case report and review of the literature. ( 28458848 )
2017
47
Vertebral fracture at the caudal end of a surgical fusion for thoracic vertebral fracture in a patient with diffuse idiopathic skeletal hyperostosis (DISH). ( 28680006 )
2017
48
CT-based morphological analysis of spinal fractures in patients with diffuse idiopathic skeletal hyperostosis. ( 27713008 )
2017
49
Classification criteria for diffuse idiopathic skeletal hyperostosis: a lack of consensus. ( 28371859 )
2017
50
Diffuse idiopathic skeletal hyperostosis (DISH) - A common but less known cause of back pain. ( 28721001 )
2017

Variations for Diffuse Idiopathic Skeletal Hyperostosis

Expression for Diffuse Idiopathic Skeletal Hyperostosis

Search GEO for disease gene expression data for Diffuse Idiopathic Skeletal Hyperostosis.

Pathways for Diffuse Idiopathic Skeletal Hyperostosis

Pathways related to Diffuse Idiopathic Skeletal Hyperostosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.18 IGF1 IGFBP3
2 10.77 IGF1 MGP
3 9.95 IGF1 IGFBP3

GO Terms for Diffuse Idiopathic Skeletal Hyperostosis

Cellular components related to Diffuse Idiopathic Skeletal Hyperostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor ternary complex GO:0042567 8.96 IGF1 IGFBP3
2 insulin-like growth factor binding protein complex GO:0016942 8.62 IGF1 IGFBP3

Biological processes related to Diffuse Idiopathic Skeletal Hyperostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 osteoblast differentiation GO:0001649 8.96 COL6A1 IGFBP3
2 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 8.62 IGF1 IGFBP3

Sources for Diffuse Idiopathic Skeletal Hyperostosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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