Diffuse Idiopathic Skeletal Hyperostosis (DISH)

Categories: Bone diseases, Metabolic diseases, Muscle diseases, Rare diseases
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Aliases & Classifications for Diffuse Idiopathic Skeletal Hyperostosis

MalaCards integrated aliases for Diffuse Idiopathic Skeletal Hyperostosis:

Name: Diffuse Idiopathic Skeletal Hyperostosis 11 19 75 14 16
Hyperostosis, Diffuse Idiopathic Skeletal 43 71
Disseminated Idiopathic Skeletal Hyperostosis 11
Hyperostosis Diffuse Idiopathic Skeletal 53
Ankylosing Vertebral Hyperostosis 11
Forestier's Disease 75
Forestier Disease 11
Dish 11


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Disease Ontology 11 DOID:6652
ICD9CM 34 721.6
MeSH 43 D004057
NCIt 49 C84671
SNOMED-CT 68 31487001
ICD10 31 M48.1
UMLS 71 C0020498

Summaries for Diffuse Idiopathic Skeletal Hyperostosis

Disease Ontology: 11 A calcinosis that is the calcification or a bony hardening of ligaments in areas where they attach to your spine.

MalaCards based summary: Diffuse Idiopathic Skeletal Hyperostosis, also known as hyperostosis, diffuse idiopathic skeletal, is related to hyperostosis and exostosis. An important gene associated with Diffuse Idiopathic Skeletal Hyperostosis is COL6A1 (Collagen Type VI Alpha 1 Chain), and among its related pathways/superpathways are Signal Transduction and Signaling by Receptor Tyrosine Kinases. The drugs Iron and Deferoxamine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and smooth muscle, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia: 75 Diffuse idiopathic skeletal hyperostosis (DISH) is a condition characterized by abnormal... more...

Related Diseases for Diffuse Idiopathic Skeletal Hyperostosis

Diseases related to Diffuse Idiopathic Skeletal Hyperostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 302)
# Related Disease Score Top Affiliating Genes
1 hyperostosis 32.4 SOST IGF1 COL6A1 ACVR1
2 exostosis 31.5 SOST BMP2 BGLAP
3 spondylitis 31.5 SOST DKK1 CRP
4 spondyloarthropathy 1 31.1 PTH CRP BGLAP
5 ossification of the posterior longitudinal ligament of spine 31.1 RSPO2 MIR563 ENPP1 COL6A1 COL11A2 CCDC91
6 enthesopathy 30.9 SOST PTH ENPP1 CRP
7 spondylosis 30.8 PTH LSS CRP BMP2
8 arthropathy 30.5 IGF1 CRP BMP2
9 chondrocalcinosis 30.5 PTH ENPP1 CRP
10 apnea, obstructive sleep 30.5 INS IGF1 CRP
11 sleep apnea 30.4 INS IGF1 CRP
12 bone disease 30.4 SOST PTH IGF1 DKK1 BMP2 BGLAP
13 spondylolisthesis 30.3 PTH LSS CRP BMP2
14 osseous heteroplasia, progressive 30.3 PTH ENPP1 BMP2 BGLAP ACVR1
15 acne 30.3 INS IGF1 CRP
16 hyperuricemia 30.2 PTH INS CRP
17 ankylosis 30.2 SOST ENPP1 DKK1 CRP BMP2 BGLAP
18 osteoarthritis 30.2 IGF1 CRP COL11A2 BMP2 BGLAP
19 osteochondrosis 30.1 PTH IGF1 CRP BMP2
20 insulin-like growth factor i 30.1 INS IGF1 BGLAP
21 cauda equina syndrome 30.0 LSS CRP
22 mammary paget's disease 30.0 SOST PTH ERBB2 BGLAP
23 rickets 30.0 PTH IGF1 ENPP1 BGLAP
24 glucose intolerance 30.0 INS IGF1 ENPP1 CRP
25 prostatic hypertrophy 30.0 INS IGF1 CRP
26 decubitus ulcer 30.0 INS IGF1 CRP
27 pseudohypoparathyroidism 30.0 PTH IGF1 BGLAP
28 fibromyalgia 30.0 INS IGF1 CRP
29 hypophosphatemic rickets, x-linked dominant 29.8 SOST PTH ENPP1 BGLAP
30 hypoparathyroidism 29.8 PTH INS BGLAP
31 prediabetes syndrome 29.4 INS IGF1 CRP
32 parathyroid gland disease 29.0 SOST PTH INS IGF1 CRP BGLAP
33 osteoporosis 28.9 SOST PTH INS IGF1 ENPP1 DKK1
34 diabetes mellitus 28.8 SOST PTH INS IGF1 ENPP1 CRP
35 chronic kidney disease 28.6 SOST PTH INS IGF1 ENPP1 DKK1
36 spinal cord disease 10.8
37 spinal stenosis 10.6
38 back pain 10.6
39 abdominal obesity-metabolic syndrome 1 10.6
40 spinal cord injury 10.5
41 spinal disease 10.5
42 hyperinsulinism 10.5
43 paraplegia 10.5
44 quadriplegia 10.5
45 swallowing disorders 10.5
46 bone mineral density quantitative trait locus 15 10.4
47 aortic atherosclerosis 10.4
48 respiratory failure 10.4
49 myeloma, multiple 10.4
50 psoriatic arthritis 10.4

Graphical network of the top 20 diseases related to Diffuse Idiopathic Skeletal Hyperostosis:

Diseases related to Diffuse Idiopathic Skeletal Hyperostosis

Symptoms & Phenotypes for Diffuse Idiopathic Skeletal Hyperostosis

MGI Mouse Phenotypes related to Diffuse Idiopathic Skeletal Hyperostosis:

# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.27 ACVR1 BGLAP BMP2 COL11A2 COL6A1 CRP
2 growth/size/body region MP:0005378 10.13 ACVR1 BMP2 COL11A2 COL6A1 DKK1 ENPP1
3 limbs/digits/tail MP:0005371 10.1 ACVR1 BMP2 DKK1 ENPP1 ERBB2 IGF1
4 hearing/vestibular/ear MP:0005377 9.8 ACVR1 BMP2 COL11A2 ENPP1 IGF1 RSPO2
5 craniofacial MP:0005382 9.76 ACVR1 BMP2 COL11A2 DKK1 ENPP1 ERBB2
6 cardiovascular system MP:0005385 9.7 ACVR1 BMP2 COL11A2 CRP ENPP1 ERBB2
7 skeleton MP:0005390 9.47 ACVR1 BGLAP BMP2 COL11A2 COL6A1 DKK1

Drugs & Therapeutics for Diffuse Idiopathic Skeletal Hyperostosis

Drugs for Diffuse Idiopathic Skeletal Hyperostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Iron Approved Phase 2 7439-89-6 29936
Deferoxamine Approved, Investigational Phase 2 70-51-9 2973
3 Iron Chelating Agents Phase 2
4 Chelating Agents Phase 2
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
6 Insulin, Globin Zinc

Interventional clinical trials:

# Name Status NCT ID Phase Drugs
1 Dietary Intervention Study for Hypertension (DISH) Completed NCT00000497 Phase 3
2 Deferoxamine In the Treatment of Aneurysmal Subarachnoid Hemorrhage (DISH) Recruiting NCT04566991 Phase 2 Deferoxamine;Placebo
3 Randomized Controlled Comparison of Single Embryo Culture Versus Group Culture Using a Micro-well Group Culture Dish in Humans Unknown status NCT02050516
4 Vanguard™ Deep Dish Rotating Platform Knee Clinical Evaluation Completed NCT00753090
5 Effectiveness of the Use of the PICSI Dish (Hyaluronan Microdot) in the Selection of Sperm for Intracytoplasmic Sperm Injection (ICSI) for Patients Having a Low Versus High Proportion of Hyaluronan Binding Sperm (HBA) Completed NCT00741494
6 DISH Data Analysis Study Completed NCT00005464
7 Eeva 12-well Dish Study Completed NCT01635036
8 Magnetic Resonance Imaging in High Risk Patients for the Development of Diffuse Idiopathic Skeletal Hyperostosis (DISH) Recruiting NCT03237455
9 Clinical Evaluation of Vanguard Deep Dish Rotating Platform Knee - Cementless Fixation With Finned Stem Active, not recruiting NCT04076202
10 Observational Study for the Evaluation of Long Term Performance and Safety of the HLS KneeTec Deep Dish Prosthesis in Total Knee Arthroplasty Active, not recruiting NCT05211141

Search NIH Clinical Center for Diffuse Idiopathic Skeletal Hyperostosis

Cochrane evidence based reviews: hyperostosis, diffuse idiopathic skeletal

Genetic Tests for Diffuse Idiopathic Skeletal Hyperostosis

Anatomical Context for Diffuse Idiopathic Skeletal Hyperostosis

Organs/tissues related to Diffuse Idiopathic Skeletal Hyperostosis:

MalaCards : Bone, Bone Marrow, Smooth Muscle, Endothelial, Dorsal Root Ganglion, Spinal Cord, Cardiac Myocytes

Publications for Diffuse Idiopathic Skeletal Hyperostosis

Articles related to Diffuse Idiopathic Skeletal Hyperostosis:

(show top 50) (show all 8652)
# Title Authors PMID Year
Retinoid and bone metabolic marker in ossification of the posterior longitudinal ligament. 53 62
9706481 1998
Ossification of the posterior longitudinal ligament, diffuse, idiopathic skeletal hyperostosis, abnormal retinol and retinol binding protein: a familial observation. 53 62
7562783 1995
Synthesis of poly vinyl chloride/chlorinated polypropylene-active natural substance derivatives for potential packaging materials application. Tannic acid, menthol and lipoic acid. 62
36358104 2023
A multifunctional heterogeneous superwettable coating for water collection, oil/water separation and oil absorption. 62
36265375 2023
Self-Assembly Culture Model for Engineering Musculoskeletal Tissues. 62
36355301 2023
Atypical ageing defect in Pinot Blanc wines: a comparison between organic and conventional production management systems. 62
36373793 2023
Genome-wide Association Study in a Dish Provides New Insights Into an Old Medication. 62
36456076 2023
A dish-like molecular architecture for dynamic ultralong room-temperature phosphorescence through reversible guest accommodation. 62
36456562 2022
Recent advances for using human induced-pluripotent stem cells as pain-in-a-dish models of neuropathic pain. 62
36100046 2022
Salvinia natans microplate assay: A simple and efficient method for evaluating aquatic toxicity. 62
36327933 2022
Development of a high-yield, high-quality purification process for adeno-associated virus vectors that can be used in vivo without ultracentrifugation: Application to a lung endothelial cell-targeted adeno-associated virus. 62
36374251 2022
The dark satanic mills: Evaluating patterns of health in England during the industrial revolution. 62
36335796 2022
Association between dietary glycemic index and glycemic load and glioma: a case-control study. 62
34633902 2022
A novel solution for freezing individual spermatozoa using a right angular cryopiece embedded in a grooved petri dish. 62
36285609 2022
Dysphagia Due to Diffuse Idiopathic Skeletal Hyperostosis. 62
36413104 2022
Coexistence of flavum ligament ossification with diffuse idiopathic skeletal hyperostosis in the cervical spine: Review of literature and technical note starting from a rare case. 62
36087693 2022
Outcomes following conservative treatment of extension fractures in the setting of diffuse idiopathic skeletal hyperostosis: is external orthosis alone a reasonable option? 62
35932260 2022
What does not kill mesangial cells makes it stronger? The response of the endoplasmic reticulum stress and the O-GlcNAc signaling to ATP depletion. 62
36279969 2022
Applying DEMATEL-ANP approach to explore the intention to hold roadside wedding banquets in Penghu: A consumers' perspective. 62
36215758 2022
Labdane diterpenoids from the heartwood of Leucosceptrum canum that impact on root growth and seed germination of Arabidopsis thaliana. 62
36464100 2022
Preparation and evaluation of dual drug-loaded nanofiber membranes based on coaxial electrostatic spinning technology. 62
36402289 2022
An in vitro human mammary epithelial cell permeability assay to assess drug secretion into breast milk. 62
35789754 2022
Dietary intake of branched-chain amino acids in relation to the risk of breast cancer. 62
35794412 2022
Improvement of the cell viability of hepatocytes cultured in three-dimensional collagen gels using pump-free perfusion driven by water level difference. 62
36434099 2022
Hydroxyapatite Affects the Physicochemical Properties of Contemporary One-Step Self-Etch Adhesives. 62
36431740 2022
Gastrointestinal helminths increase Bordetella bronchiseptica shedding and host variation in supershedding. 62
36346138 2022
Transwell-Hypoxia Method Facilitates the Outgrowth of 3D-Printed Collagen Scaffolds Loaded with Cryopreserved Patient-Derived Melanoma Explants. 62
36265170 2022
Observational study of sterile field bioburden levels during orthopedic arthroplasty surgery in operating rooms complying with current United States ventilation specifications. 62
36375706 2022
Phytotoxic meroterpenoids with herbicidal activities from the phytopathogenic fungus Pseudopestalotiopsis theae. 62
36471552 2022
Air concentrations of volatile organic compounds associated with conventional and "green" cleaning products in real-world and laboratory settings. 62
36437676 2022
Modulating Surface Electron Density of Heterointerface with Bio-Inspired Light-Trapping Nano-Structure to Boost Kinetics of Overall Water Splitting. 62
36336631 2022
Alleviation of Severe Skin Insults Following High-Dose Irradiation with Isolated Human Fetal Placental Stromal Cells. 62
36362110 2022
Radio Astronomical Antennas in the Central African Region to Improve the Sampling Function of the VLBI Network in the SKA Era? 62
36366161 2022
Carnegie in 4D? Stem-cell-based models of human embryo development. 62
35701286 2022
Osteophytes' position in subjects with DISH and right-sided aorta: verification of the 'aortic pulsation protective effect' theory. 62
35353143 2022
A case of diffuse idiopathic hyperostosis of bone (DISH) in a patient on hemodialysis. 62
36401745 2022
Tumor necrosis factor alpha and palmitate simulate bovine fatty liver disease in vitro when using abattoir-derived primary bovine hepatocytes isolated by a novel nonperfusion method. 62
36465509 2022
Association of AK4 Protein From Stem Cell-Derived Neurons With Cognitive Reserve: An Autopsy Study. 62
35948448 2022
Back-to-back: The co-occurrence of DISH and ankylosing spondylitis from early modern Poland. 62
36375277 2022
Outcomes of spinal cord injury following cervical fracture in ankylosing spondylitis and diffuse idiopathic skeletal hyperostosis (DISH): A prospective cohort study. 62
36333086 2022
Cardiovascular (Framingham) and type II diabetes (Finnish Diabetes) risk scores: a qualitative study of local knowledge of diet, physical activity and body measurements in rural Rakai, Uganda. 62
36447173 2022
Investigations of an organic-inorganic nanotheranostic hybrid for pancreatic cancer therapy using cancer-in-a-dish andin vivomodels. 62
36270604 2022
The organoid as reliable cancer modeling in personalized medicine, does applicable in precision medicine of head and neck squamous cell carcinoma? 62
36347937 2022
Modeling PTSD neuronal stress responses in a dish. 62
36266472 2022
The Effect of Spice Powders on Bioactive Compounds, Antioxidant Activity, Phenolic Components, Fatty Acids, Mineral Contents and Sensory Properties of "Keşkek", Which Is a Traditional Food. 62
36360106 2022
Microenvironmental Analysis and Control for Local Cells under Confluent Conditions via a Capillary-Based Microfluidic Device. 62
36383697 2022
Chemical Composition and Evaluation of Insecticidal Activity of Seseli bocconei Essential Oils against Stored Products Pests. 62
36432776 2022
Attraction of Myzus persicae (Hemiptera: Aphididae) to Volatiles Emitted From the Entomopathogenic Fungus Beauveria bassiana. 62
36421055 2022
Association of ALDH2 Genotypes and Alcohol Intake with Dietary Patterns: The Bunkyo Health Study. 62
36432517 2022
Insecticidal activities of the local entomopathogenic nematodes and cell-free supernatants from their symbiotic bacteria against the larvae of fall webworm, Hyphantriacunea. 62
36116520 2022

Variations for Diffuse Idiopathic Skeletal Hyperostosis

Expression for Diffuse Idiopathic Skeletal Hyperostosis

Search GEO for disease gene expression data for Diffuse Idiopathic Skeletal Hyperostosis.

Pathways for Diffuse Idiopathic Skeletal Hyperostosis

GO Terms for Diffuse Idiopathic Skeletal Hyperostosis

Cellular components related to Diffuse Idiopathic Skeletal Hyperostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10 BGLAP BMP2 COL11A2 COL6A1 CRP DKK1
2 extracellular region GO:0005576 9.68 SOST RSPO2 PTH INS IGF1 ENPP1
3 BMP receptor complex GO:0070724 9.46 BMP2 ACVR1

Biological processes related to Diffuse Idiopathic Skeletal Hyperostosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.18 PTH INS IGF1 ERBB2 DKK1 CRP
2 positive regulation of MAPK cascade GO:0043410 10.08 INS IGF1 ERBB2 BMP2
3 positive regulation of bone mineralization GO:0030501 9.91 PTH BMP2 ACVR1
4 positive regulation of glucose import GO:0046326 9.88 IGF1 INS PTH
5 cellular response to growth factor stimulus GO:0071363 9.87 ACVR1 BGLAP BMP2 ERBB2
6 skeletal system development GO:0001501 9.85 PTH IGF1 COL11A2 BMP2 BGLAP
7 negative regulation of cardiac muscle cell differentiation GO:2000726 9.8 DKK1 BMP2
8 BMP signaling pathway involved in heart development GO:0061312 9.76 BMP2 ACVR1
9 positive regulation of glycogen biosynthetic process GO:0045725 9.73 PTH INS IGF1
10 osteoblast differentiation GO:0001649 9.61 RSPO2 COL6A1 COL11A2 BMP2 BGLAP
11 bone mineralization GO:0030282 9.32 RSPO2 PTH ENPP1 BMP2 BGLAP

Molecular functions related to Diffuse Idiopathic Skeletal Hyperostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.1 INS IGF1 ENPP1

Sources for Diffuse Idiopathic Skeletal Hyperostosis

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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