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DISH
MCID: DFF006
MIFTS: 48

Diffuse Idiopathic Skeletal Hyperostosis (DISH)

Categories: Bone diseases, Metabolic diseases, Muscle diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Diffuse Idiopathic Skeletal Hyperostosis

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MalaCards integrated aliases for Diffuse Idiopathic Skeletal Hyperostosis:

Name: Diffuse Idiopathic Skeletal Hyperostosis 12 74 52 36 15 17
Hyperostosis, Diffuse Idiopathic Skeletal 43 71
Forestier Disease 12 52
Dish 12 52
Disseminated Idiopathic Skeletal Hyperostosis 12
Hyperostosis Diffuse Idiopathic Skeletal 54
Ankylosing Vertebral Hyperostosis 12
Dish Forestier's Disease 52
Forestier-Rotes Disease 52
Forestier's Disease 74

Classifications:

MalaCards categories:
Global: Rare diseases Metabolic diseases
Anatomical: Bone diseases Muscle diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:6652
KEGG 36 H01708
ICD9CM 34 721.6
MeSH 43 D004057
NCIt 49 C84671
SNOMED-CT 67 31487001
ICD10 32 M48.1
UMLS 71 C0020498
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Summaries for Diffuse Idiopathic Skeletal Hyperostosis

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KEGG : 36 Diffuse idiopathic skeletal hyperostosis (DISH), also known as Forestier disease, is a systemic noninflammatory disease characterized by ossification of the entheses. It affects mainly elderly men, and involves the ossification of the anterior longitudinal ligament (OALL). Although it is asymptomatic in some occasions, the disease may produce dysphagia, dysphonia, and exceptionally breathing difficulties due to airway compromise. In these cases, early surgery is recommended to alleviate airway obstruction. Although the hallmark of the DISH is considered to be the anterolateral aspect of the thoracic spine, various signs and symptoms is not limited to the spine and has often been reported to involve multiple peripheral locations as well. While the cause of DISH remains unclear, mechanical factors, genetic factors, environmental factors, drugs, and metabolic conditions have been hypothesized to be relevant. Most of the current theories focus on the pathologic OALL. There's no cure for DISH. Therapy for DISH is based on symptomatic and empiric treatment. In general, physical therapy, analgesics, antiinflammatory drugs, and muscle relaxants have been successful in managing the majority of patients with DISH.

MalaCards based summary : Diffuse Idiopathic Skeletal Hyperostosis, also known as hyperostosis, diffuse idiopathic skeletal, is related to ossification of the posterior longitudinal ligament of spine and hyperostosis. An important gene associated with Diffuse Idiopathic Skeletal Hyperostosis is COL6A1 (Collagen Type VI Alpha 1 Chain), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers and Senescence and Autophagy in Cancer. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and heart, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 A calcinosis that is the calcification or a bony hardening of ligaments in areas where they attach to your spine.

NIH Rare Diseases : 52 Diffuse idiopathic skeletal hyperostosis (DISH) is a common skeletal disorder characterized by unusual, new bone formation. The new bone forms most often where ligaments and tendons (connective tissues that connect bones) join bone (entheseal area ), but there is also a generalized hardening of bones and bone overgrowth (hyperostosis). Although these changes are most often seen in the spine , DISH can affect almost any part of the skeleton, including hips, knees, ankles, feet, shoulders, hands, and ribs. Many people with DISH do not have any symptoms, but in some cases the symptoms get worse over time (progressive) and become quite severe. The most common symptoms are pain, stiffness and reduced range of motion of the neck or upper back. DISH is caused by the build up of calcium salts in the tendons and ligaments (calcification) and abnormal new bone growth (ossification) but the reason this happens is unknown. Researchers believe some combination of mechanical, genetic , environmental, and metabolic factors are involved. DISH is more common in people over 50 and in men. While there is no known cure for DISH, there are treatments that can help control symptoms.

Wikipedia : 74 Diffuse idiopathic skeletal hyperostosis (DISH) is a condition characterized by abnormal... more...

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Related Diseases for Diffuse Idiopathic Skeletal Hyperostosis

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Diseases related to Diffuse Idiopathic Skeletal Hyperostosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 240)
# Related Disease Score Top Affiliating Genes
1 ossification of the posterior longitudinal ligament of spine 33.4 TMTC1 COL6A1 CCDC91
2 hyperostosis 32.9 IGFBP3 IGF1 COL6A1
3 sleep apnea 31.1 INS IGF1 ALB
4 insulin-like growth factor i 30.9 INS IGFBP3 IGF1
5 glucose intolerance 30.7 INS IGFBP3 IGF1 ALB
6 apnea, obstructive sleep 30.6 INS IGF1 ALB
7 myeloma, multiple 30.4 PRDM10 IGF1 GAPDH FN1 FGF2 ALB
8 neurofibromatosis, type ii 30.3 PRDM10 GAPDH ALB
9 peripheral nervous system disease 29.7 PRDM10 MRAP INS IGF1 GAPDH FN1
10 retinitis pigmentosa 28.3 TCOF1 SP8 PRDM10 MRAP INS IGF1
11 dysphagia 11.0
12 inflammatory spondylopathy 10.9
13 spondylitis 10.9
14 spondyloarthropathy 1 10.9
15 exostosis 10.7
16 ankylosis 10.7
17 enthesopathy 10.7
18 spondylosis 10.7
19 back pain 10.6
20 slipped capital femoral epiphysis 10.6 IGFBP3 IGF1
21 mammographic density 10.5 IGFBP3 IGF1
22 spinal cord injury 10.5
23 hypothalamic obesity 10.5 INS IGF1
24 hyperinsulinism 10.5
25 paraplegia 10.5
26 swallowing disorders 10.5
27 secondary adrenal insufficiency 10.5 INS IGFBP3 IGF1
28 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.5 INS IGFBP3 IGF1
29 fetal macrosomia 10.5 INS IGFBP3 IGF1
30 empty sella syndrome 10.4 INS IGFBP3 IGF1
31 hyperpituitarism 10.4 INS IGFBP3 IGF1
32 pituitary infarct 10.4 INS IGF1
33 donohue syndrome 10.4 INS IGFBP3 IGF1
34 haemonchiasis 10.4 PRDM10 HUWE1
35 spinal disease 10.4
36 quadriplegia 10.4
37 acidophil adenoma 10.4 INS IGF1
38 critical illness polyneuropathy 10.4 INS ALB
39 anovulation 10.4 INS IGFBP3 IGF1
40 spinal stenosis 10.4
41 nutritional deficiency disease 10.4 IGFBP3 IGF1 ALB
42 pigmentation disease 10.4 INS IGF1 ALB
43 disorders of sexual development 10.4 INS IGFBP3 IGF1
44 persistent fetal circulation syndrome 10.4 INS IGF1 ALB
45 macular retinal edema 10.4 MRAP INS ALB
46 pituitary gland disease 10.4 INS IGFBP3 IGF1
47 blood group, globoside system 10.4 MRAP FGF2 ALB
48 sexual disorder 10.4 INS IGF1 ALB
49 amebiasis 10.4 PRDM10 FN1 ALB
50 prediabetes syndrome 10.4 INS IGF1 ALB

Graphical network of the top 20 diseases related to Diffuse Idiopathic Skeletal Hyperostosis:



Diseases related to Diffuse Idiopathic Skeletal Hyperostosis
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Symptoms & Phenotypes for Diffuse Idiopathic Skeletal Hyperostosis

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GenomeRNAi Phenotypes related to Diffuse Idiopathic Skeletal Hyperostosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.53 TIE1
2 Decreased viability GR00221-A-4 9.53 TIE1
3 Decreased viability GR00249-S 9.53 ADD2 ALB COL6A1 FGF2 GAPDH IGFBP3
4 Decreased viability GR00342-S-1 9.53 TIE1
5 Decreased viability GR00342-S-2 9.53 TIE1
6 Decreased viability GR00342-S-3 9.53 TIE1
7 Decreased viability GR00381-A-1 9.53 PRDM10
8 Decreased viability GR00386-A-1 9.53 ADD1 ALB FGF2
9 Decreased viability GR00402-S-2 9.53 IGFBP3

MGI Mouse Phenotypes related to Diffuse Idiopathic Skeletal Hyperostosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.18 ADD1 COL6A1 FN1 GAPDH HUWE1 IGF1
2 homeostasis/metabolism MP:0005376 10.18 ADD1 ADD2 ALB COL6A1 FGF2 FN1
3 cardiovascular system MP:0005385 10.17 ADD2 ADD3 ALB FGF2 FN1 GAPDH
4 mortality/aging MP:0010768 10.07 ADD1 ALB FGF2 FN1 GAPDH HUWE1
5 liver/biliary system MP:0005370 9.87 ADD2 ALB FN1 GAPDH IGFBP3 INS
6 muscle MP:0005369 9.76 ALB COL6A1 FGF2 FN1 IGF1 IGFBP3
7 nervous system MP:0003631 9.7 ADD1 ADD2 FGF2 FN1 HUWE1 IGF1
8 renal/urinary system MP:0005367 9.23 ADD2 ALB GAPDH HUWE1 IGF1 INS
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Drugs & Therapeutics for Diffuse Idiopathic Skeletal Hyperostosis

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Drugs for Diffuse Idiopathic Skeletal Hyperostosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 134)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Racepinephrine Approved Phase 4 329-65-7 838
3
Castor oil Approved, Investigational, Nutraceutical, Vet_approved Phase 4 8001-79-4
4 Pharmaceutical Solutions Phase 4
5 Disinfectants Phase 4
6 Eusol Phase 4
7 Castor Phase 4
8 Epinephryl borate Phase 4
9 Sodium hypochlorite Phase 4
10
Chlorthalidone Approved Phase 3 77-36-1 2732
11
Atenolol Approved Phase 3 29122-68-7 2249
12
Ramipril Approved Phase 3 87333-19-5 5362129
13
Simvastatin Approved Phase 3 79902-63-9 54454
14
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
15
Chitosan Experimental Phase 3 9012-76-4 71853
16 Hemostatics Phase 3
17 Hypolipidemic Agents Phase 3
18 Chelating Agents Phase 3
19 Lipid Regulating Agents Phase 3
20 Anticholesteremic Agents Phase 3
21 Antimetabolites Phase 3
22 Coagulants Phase 3
23 Adrenergic beta-1 Receptor Antagonists Phase 3
24 Sodium Chloride Symporter Inhibitors Phase 3
25 Antihypertensive Agents Phase 3
26 Adrenergic Agents Phase 3
27 Sympatholytics Phase 3
28 Anti-Arrhythmia Agents Phase 3
29 Adrenergic beta-Antagonists Phase 3
30 Adrenergic Antagonists Phase 3
31 diuretics Phase 3
32
Guaifenesin Approved, Investigational, Vet_approved Phase 2 93-14-1 3516
33
Ethanol Approved Phase 2 64-17-5 702
34
Nitric Oxide Approved Phase 2 10102-43-9 145068
35 Chlorpheniramine, phenylpropanolamine drug combination Phase 2
36 Antioxidants Phase 2
37 Anti-Bacterial Agents Phase 2
38 Anti-Infective Agents Phase 2
39 Protective Agents Phase 2
40 Respiratory System Agents Phase 2
41 Vasodilator Agents Phase 2
42 Endothelium-Dependent Relaxing Factors Phase 2
43 Anti-Asthmatic Agents Phase 2
44 Bronchodilator Agents Phase 2
45
Thrombin Approved, Investigational Phase 1
46
Lutein Approved, Investigational, Nutraceutical Phase 1 127-40-2 6433159
47 Carotenoids Phase 1
48 Fibrin Tissue Adhesive Phase 1
49 Coconut Approved
50
Triclosan Approved, Investigational 3380-34-5 5564

Interventional clinical trials:

(show top 50) (show all 129)
# Name Status NCT ID Phase Drugs
1 Comparison of the Ahmed Glaucoma Valve FP7 and FP8 in Pediatric Glaucoma: a Randomized Clinical Trial. Unknown status NCT01494974 Phase 4
2 Clinical Evaluation of an Experimental Solution Based on Ricinus Communis Compared to Sodium Hypochlorite for Denture Cleansing Completed NCT02407834 Phase 4
3 Prospective Randomized, Double-Blind, Controlled Trial Comparing Lichtenstein's Repair of Inguinal Hernia With Polypropylene Mesh Versus Surgisis ES Soft Tissue Graft Completed NCT00614419 Phase 4
4 The Effect of Special Diets on Weight and Nutritional Intake in Haematological Cancer Patients Completed NCT02880709 Phase 4
5 Time Lapse Embryo Monitoring Versus Standard Embryo Monitoring for Selection for Single Blastocyst Transfer Terminated NCT01694641 Phase 4
6 A Randomized Controlled Trial Comparing Global Medium With G-TL, Cornell Single and Sequential Steps Media by the Time-Lapse System. Withdrawn NCT03687697 Phase 4
7 A Randomized Controlled Trial of Treatment Protocols to Optimize Outcomes in Poor Responder In Vitro Fertilization (IVF) Patients: E2 Patch/Antagonist Protocol Versus OCP/Microdose Lupron Protocol Withdrawn NCT00826839 Phase 4 Oral contraceptive pill and microdose lupron;E2 patch/antagonist
8 Therapeutic Efficacy of Tricalcium Phosphate and Chitosan as Bone Regenerator Versus Autologous Graft in Surgery for Mandibular Fracture Unknown status NCT02081885 Phase 3
9 Trial of Antihypertensive Intervention Management Completed NCT00000513 Phase 3 chlorthalidone;atenolol
10 Dietary Intervention Study for Hypertension (DISH) Completed NCT00000497 Phase 3
11 Coronally Advanced Flap With Connective Tissue Graft and PRF for Recession Coverage Completed NCT03023995 Phase 3
12 Comparison of Surgical Glove Contamination During Total Knee Arthroplasty Procedure Recruiting NCT04308798 Phase 3
13 Multi-cap for Increase Adherence After Acute Myocardial Infarction Terminated NCT02271178 Phase 3
14 The Effects of Different Medical Marijuana Strains on Motor and Cognitive Function in People With Multiple Sclerosis Withdrawn NCT03172741 Phase 2, Phase 3 Medical Marijuana;Placebo
15 The Effectiveness and Efficacy of Using JUC Antimicrobial Spray for Controlling the Infection Transmission Completed NCT01824888 Phase 2 JUC solution;propan-2-ol
16 Evaluation of the Efficacy of a Novel Synthetic Bone Regeneration Material (Sil-Oss®) In the Treatment of Periodontal Intrabony Osseous Defects Completed NCT02639572 Phase 2
17 An Open Label Safety Study of Inhaled Gaseous Nitric Oxide (gNO) for Adults & Adolescents With Non-Tuberculous Mycobacteria, Burkholderia Spp, Aspergillus Spp and Corona-like Viral (Sub-Study) Infections Active, not recruiting NCT03331445 Phase 2 Nitric Oxide 0.5 % / Nitrogen 99.5 % Gas for Inhalation
18 Ex-vivo Cultivated Limbal Stem Cell Transplantation for Treatment of Superficial Corneal Pathologies Unknown status NCT02948023 Phase 1
19 In Vitro Human Embryo Culture System Completed NCT00985218 Phase 1
20 Injection of Day 2 Embryo Culture Supernatant Into the Uterine Cavity Didn't Improve Implantation and Pregnancy Rates of Day 3 Embryo Transfer: a Randomized Clinical Trial in Patients Who Underwent in Vitro Fertilization- Embryo Transfer. Completed NCT00730496 Phase 1
21 Bioavailability of Pepper Carotenoids in Humans Completed NCT00636350 Phase 1
22 Use of Mouse Renal Adenocarcinoma Cell-containing Agarose-agarose Macrobeads in the Treatment of Patients With End-stage, Treatment-resistant Epithelial-derived Cancer Completed NCT00283075 Phase 1
23 Pilot Clinical Trial to Assess the Safety of Limbus-derived Corneal Stem Cells in Prevention of Corneal Haze After Photo Therapeutic/Refractive Keratectomy (PTK/ PRK) and Collagen Cross Linking (CXL) Recruiting NCT03295292 Phase 1
24 Comparative Study of The Relationship Between the Sacroiliac Joint (SIJ) and Lumbopelvic Configurations With SIJ Nerve Entrapments and Chronic Low Back Pain Unknown status NCT02115009
25 Randomized Controlled Comparison of Single Embryo Culture Versus Group Culture Using a Micro-well Group Culture Dish in Humans Unknown status NCT02050516
26 Glycemic Index, Glycemic Load and Common Psychological Disorders Unknown status NCT02362113
27 Multicentric Clinical Trial to Improve Blastocyst Utilisation Rate (in Relation to 2 PN Embryos) by Group Culture of Human Embryos in WOW Dishes. Unknown status NCT02010424
28 Clinical Study Randomized of the Effects of the Administered Time of Meal on the Treatment of Overweight and Obesity Unknown status NCT03347942
29 Comparing Chlorhexidine Gluconate, Sodium Fluoride, Coconut Oil and Water Mouth Rinses in Regard to Streptococcus Mutan Reduction Unknown status NCT02598778 Chlorhexidine gluconate (.12%);Sodium Fluoride (.05%)
30 The Influence of Different Concentrations of Glucose in Culture Media(i.e: ISM1 vs. IVF) on Fertilization and Embryo Quality Unknown status NCT00606073
31 Evaluating the Validity of the "Categories" Method: a New Method for Self-report Assessment of Daily Calorie Intake Unknown status NCT01408784
32 Acceptability of Products and Eating Pleasure in Elderly People Living at Home or in an EHPAD Unknown status NCT02873897
33 Triclosan, Triclocarban, and the Microbiota Unknown status NCT01509976
34 A Prospective, Randomized Trial to Compare Mono-menotropins Protocol for Controlled Ovarian Stimulation (COS) Versus Recombinant Follicle Stimulating Hormone (rFSH) Protocol on Embryo Quality Parameters in IVF Patients Unknown status NCT02418533 menotropin;Recominant Follicle Stimulating Hormone (rFSH)
35 Warm Needle Acupuncture vs. Needle Acupuncture for Osteoarthritis of the Knee: A Pilot Study Unknown status NCT02680912
36 Effect of Food Consumption on microRNA Related to Metabolic Syndrome. A Randomized Clinical Trial Unknown status NCT02606812
37 Blastocyst Developmental Rate in Two Different Single Step Culture Media: a Sibling Oocyte Prospective Non-interventional Study Unknown status NCT03497052
38 Comparison of 3 Learning Methods and Their Underlying Mechanisms to Improve Independent Living in the Activities of Daily Living in Alzheimer's Dementia: a Randomized Controlled Trial Unknown status NCT01095718
39 The Role of TBX3 in Human ES Cell Differentiation Unknown status NCT00581152
40 Comparative Clinical Evaluation of Osseointegration of Dental Implants Placed With and Without, the Use of Dental Pulp-derived Allogenic Mesenchymal Stem Cells. Unknown status NCT02731586 Early Phase 1 Allogenic Mesenchymal stem cells
41 A Comparative Study Between Autologous Non Cultured Epidermal Cell Suspension Versus Combination of Autologous Non Cultured Epidermal Cell Suspension and Non Cultured Dermal Cell Suspension in Stable Vitiligo Unknown status NCT03013049
42 DISH Data Analysis Study Completed NCT00005464
43 Eeva 12-well Dish Study Completed NCT01635036
44 The Effect of Potatoes on Markers of Cardiometabolic Health Completed NCT03495284
45 Socioeconomic Position and the Impact of Increasing Availability of Lower Energy Meals vs. Menu Energy Labelling on Food Choice in Virtual Full-service Restaurants: Two Randomized Control Trials Completed NCT04336540
46 Effectiveness of the Use of the PICSI Dish (Hyaluronan Microdot) in the Selection of Sperm for Intracytoplasmic Sperm Injection (ICSI) for Patients Having a Low Versus High Proportion of Hyaluronan Binding Sperm (HBA) Completed NCT00741494
47 Effectiveness of the Carbohydrate Counting Method on Postprandial Glucose Concentrations After Consumption of Mixed Meals in Adults With Type 1 Diabetes Completed NCT02928016
48 A Randomized Crossover Trial to Compare the Changes of Postprandial Oxidative Stress After Consumption of Meals From Different Cultures in Healthy Chinese Adults Completed NCT02006771
49 Evaluation of the Impact of Reduced Oxygen Concentration on Embryonic Development Completed NCT02919384
50 Eeva Continued Access Study. Completed NCT01617993

Search NIH Clinical Center for Diffuse Idiopathic Skeletal Hyperostosis

Cochrane evidence based reviews: hyperostosis, diffuse idiopathic skeletal

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Genetic Tests for Diffuse Idiopathic Skeletal Hyperostosis

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Anatomical Context for Diffuse Idiopathic Skeletal Hyperostosis

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MalaCards organs/tissues related to Diffuse Idiopathic Skeletal Hyperostosis:

40
Bone, Spinal Cord, Heart, Colon, Liver, Testes, Skin
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Publications for Diffuse Idiopathic Skeletal Hyperostosis

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Articles related to Diffuse Idiopathic Skeletal Hyperostosis:

(show top 50) (show all 828)
# Title Authors PMID Year
1
Is diffuse idiopathic skeletal hyperostosis a disease or a syndrome? 52 61
28013194 2017
2
Diffuse idiopathic skeletal hyperostosis: Diagnostic, clinical, and paleopathological considerations. 52 61
27004482 2016
3
Retinoid and bone metabolic marker in ossification of the posterior longitudinal ligament. 61 54
9706481 1998
4
Ossification of the posterior longitudinal ligament, diffuse, idiopathic skeletal hyperostosis, abnormal retinol and retinol binding protein: a familial observation. 54 61
7562783 1995
5
Craniocervical junction involvement in musculoskeletal diseases: an area of close collaboration between rheumatologists and radiologists. 61
32088810 2020
6
Comments on the Article "Arthroscopic Treatment for Femoroacetabular Impingement with Extraspinal Diffuse Idiopathic Skeletal Hyperostosis": To the Editor. 61
32489551 2020
7
Comments on the Article "Arthroscopic Treatment for Femoroacetabular Impingement with Extraspinal Diffuse Idiopathic Skeletal Hyperostosis": In Reply. 61
32489552 2020
8
Design of primers for direct sequencing of nine coding exons in the human ACVR1 gene. 61
32512165 2020
9
Differences between diffuse idiopathic skeletal hyperostosis and spondyloarthritis. 61
32571112 2020
10
DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS WITH SECONDARY DYSPHAGIA IN A BLACK-HANDED SPIDER MONKEY (ATELES GEOFFROYI). 61
32549579 2020
11
Surgical stabilization of spinal metastasis in diffuse idiopathic skeletal hyperostosis ("Mets-on-DISH"): Two case reports. 61
32481429 2020
12
Diffuse Idiopathic Skeletal Hyperostosis of the Cervical Spine: A Risk for Acute Airway Obstruction. 61
32469245 2020
13
Diffuse idiopathic skeletal hyperostosis: Etiology and clinical relevance. 61
32456997 2020
14
Functional characterization of a unique mutant of ALK2, p.K400E, that is associated with a skeletal disorder, diffuse idiopathic skeletal hyperostosis. 61
32437875 2020
15
Activities of Daily Living after Surgical Treatment for Osteoporotic Vertebral Fracture with or without Diffuse Idiopathic Skeletal Hyperostosis: A Retrospective Single-Institutional Study. 61
32460468 2020
16
Thoracic hyperextension injury with opening wedge distraction fracture in DISH -consideration of surgical strategy based on intraoperative pathological findings. 61
32178994 2020
17
[Dysphagia caused by osteophytes of the cervical spine]. 61
32395960 2020
18
Prevalence of Diffuse Idiopathic Skeletal Hyperostosis in the General Elderly Population: A Japanese Cohort Survey Randomly Sampled From a Basic Resident Registry. 61
31851012 2020
19
Whole Spine CT Scan for the Detection of Acute Spinal Fractures in Diffuse Idiopathic Skeletal Hyperostosis Patients Who Sustained Low-energy Trauma. 61
32341308 2020
20
Diffuse Idiopathic Skeletal Hyperostosis in a Patient With Shoulder Pain. 61
32241232 2020
21
Diffuse Idiopathic Skeletal Hyperostosis in Smokers and Restrictive Spirometry Pattern: An Analysis of the COPDGene Cohort. 61
31043539 2020
22
Diffuse Idiopathic Skeletal Hyperostosis, Associated Morbidity, and Healthcare Utilization: A University Hospital Experience. 61
30585993 2020
23
Surgical Outcomes of Dysphagia Provoked by Diffuse Idiopathic Skeletal Hyperostosis in the Cervical Spine. 61
32233177 2020
24
Lethal mesenteric perforation by osteophytes after blunt abdominal trauma. 61
32239426 2020
25
Diffuse idiopathic skeletal hyperostosis with esophageal involvement mimicking esophageal cancer. 61
32343820 2020
26
Diffuse idiopathic skeletal hyperostosis with esophageal involvement mimicking esophageal cancer. 61
31586426 2020
27
Swallowing Difficulty in Diffuse Idiopathic Skeletal Hyperostosis with Metabolic Syndrome. 61
32395457 2020
28
Diffuse idiopathic skeletal hyperostosis in subjects with congestive heart failure undergoing cardiac rehabilitation: A decision tree analysis. 61
32104899 2020
29
Enthesopathy of the anterior chest wall joints in patients with diffuse idiopathic skeletal hyperostosis (DISH): a retrospective analysis of computed tomography scans. 61
31501958 2020
30
Incidence of diffuse idiopathic skeletal hyperostosis from a model of dysphagia. 61
31122675 2020
31
Back to the beginning: Identifying lesions of diffuse idiopathic skeletal hyperostosis prior to vertebral ankylosis. 61
31951851 2020
32
Correction: Imaging of diffuse idiopathic skeletal hyperostosis (DISH). 61
32169886 2020
33
Rib Hyperostosis as a Risk Factor for Poor Prognosis in Cervical Spine Injury Patients With Diffuse Idiopathic Skeletal Hyperostosis. 61
31524820 2020
34
Forestier Rotes-Querol disease (diffuse idiopathic skeletal hyperostosis). 61
32067702 2020
35
Improvement of Swallowing Function After Surgical Treatment of Diffuse Idiopathic Skeletal Hyperostosis: Our Experience. 61
31470164 2020
36
Sacroiliac joint variation associated with diffuse idiopathic skeletal hyperostosis. 61
32041573 2020
37
Imaging of diffuse idiopathic skeletal hyperostosis (DISH). 61
32111653 2020
38
Diffuse idiopathic skeletal hyperostosis: A potential factor in the induction of thoracic spondylotic myelopathy. 61
32063469 2020
39
Trabecular bone score and bone turnover markers in men with DISH: Data from the Camargo Cohort study. 61
32093967 2020
40
Retro-odontoid pseudotumor (pannus) with Forestier's disease presenting with severe tetraparesis: A case report and literature review. 61
32494387 2020
41
Surgical Treatment of Osteoporotic Vertebral Fracture Associated with Diffuse Idiopathic Skeletal Hyperostosis along with Comparative Assessment of the Levels of Affected Vertebra or Anterior Column Reconstruction. 61
32039298 2020
42
A Comparison of Cervical and Thoracolumbar Fractures Associated with Diffuse Idiopathic Skeletal Hyperostosis-A Nationwide Multicenter Study. 61
31940926 2020
43
Dysphagia in a Young Adult: Rare Case of Giant Cervical Osteophyte. 61
32181207 2020
44
Progressive dysphagia and dysphonia secondary to DISH-related anterior cervical osteophytes: A case report. 61
32363064 2020
45
CT-Based Evaluation of Diffuse Idiopathic Skeletal Hyperostosis in Adult Population; Prevalence, Associations and Interobserver Agreement. 61
30583921 2020
46
Dystrophic calcification and heterotopic ossification in fibrocartilaginous tissues of the spine in diffuse idiopathic skeletal hyperostosis (DISH). 61
32257530 2020
47
A case study of vertebral fusion in a 19th-century horse from Serbia. 61
31550619 2019
48
Atypical case of diffuse idiopathic skeletal hyperostosis mimicking ankylosing spondylitis in a young woman with polycystic ovary syndrome. 61
31929491 2019
49
Patients with ankylosing spondylitis suffering from AO Type B3 traumatic thoracolumbar fractures are associated with increased frailty and morbidity when compared with patients with diffuse idiopathic skeletal hyperostosis. 61
32042992 2019
50
Outcomes of lumbar decompression surgery in patients with diffuse idiopathic skeletal hyperostosis (DISH). 61
31551180 2019
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Variations for Diffuse Idiopathic Skeletal Hyperostosis

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Expression for Diffuse Idiopathic Skeletal Hyperostosis

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Search GEO for disease gene expression data for Diffuse Idiopathic Skeletal Hyperostosis.
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Pathways for Diffuse Idiopathic Skeletal Hyperostosis

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Pathways related to Diffuse Idiopathic Skeletal Hyperostosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers 64
11.68 INS IGF1 FGF2 ALB
2
Senescence and Autophagy in Cancer 1
11.48 INS IGFBP3 IGF1 FN1
3
Cardiac Progenitor Differentiation 1
11.27 INS IGF1 FGF2
4
Differentiation Pathway 1
11.18 INS IGF1 FGF2
5
Mesenchymal Stem Cells and Lineage-specific Markers 64
11 INS IGFBP3 IGF1 FN1 FGF2
6
G-protein signaling_Rap2B regulation pathway 22
10.71 TIE1 IGF1 FN1 FGF2 COL6A1
7
Cori Cycle 1
10.64 INS GAPDH
8
Miscellaneous transport and binding events 65
10.41 ADD3 ADD2 ADD1
Sources

GO Terms for Diffuse Idiopathic Skeletal Hyperostosis

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Cellular components related to Diffuse Idiopathic Skeletal Hyperostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.01 INS IGFBP3 IGF1 H2BC21 FN1 FGF2
2 endoplasmic reticulum lumen GO:0005788 9.55 INS IGFBP3 FN1 COL6A1 ALB
3 platelet alpha granule lumen GO:0031093 9.5 IGF1 FN1 ALB
4 F-actin capping protein complex GO:0008290 9.37 ADD2 ADD1
5 insulin-like growth factor ternary complex GO:0042567 9.26 IGFBP3 IGF1
6 insulin-like growth factor binding protein complex GO:0016942 8.96 IGFBP3 IGF1
7 plasma membrane raft GO:0044853 8.8 ADD3 ADD2 ADD1

Biological processes related to Diffuse Idiopathic Skeletal Hyperostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 wound healing GO:0042060 9.54 INS FN1 FGF2
2 positive regulation of MAPK cascade GO:0043410 9.46 INS IGFBP3 IGF1 FGF2
3 actin filament bundle assembly GO:0051017 9.43 ADD3 ADD2 ADD1
4 cellular protein metabolic process GO:0044267 9.35 INS IGFBP3 IGF1 FN1 ALB
5 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.32 IGFBP3 IGF1
6 barbed-end actin filament capping GO:0051016 8.8 ADD3 ADD2 ADD1

Molecular functions related to Diffuse Idiopathic Skeletal Hyperostosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 MRAP INS GAPDH FN1 FGF2 CCDC91
2 structural constituent of cytoskeleton GO:0005200 9.33 ADD3 ADD2 ADD1
3 insulin-like growth factor receptor binding GO:0005159 9.26 INS IGF1
4 spectrin binding GO:0030507 8.8 ADD3 ADD2 ADD1
Sources

Sources for Diffuse Idiopathic Skeletal Hyperostosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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