MCID: DFF007
MIFTS: 27

Diffuse Infiltrative Lymphocytosis Syndrome

Categories: Immune diseases

Aliases & Classifications for Diffuse Infiltrative Lymphocytosis Syndrome

MalaCards integrated aliases for Diffuse Infiltrative Lymphocytosis Syndrome:

Name: Diffuse Infiltrative Lymphocytosis Syndrome 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:6677
NCIt 49 C35699
SNOMED-CT 67 449784008
UMLS 71 C1333292

Summaries for Diffuse Infiltrative Lymphocytosis Syndrome

Disease Ontology : 12 A syndrome that occurs in human immunodeficiency virus (HIV) positive patients, which is accompanied by decreased kidney function. The spectrum of kidney involvement includes acute or chronic kidney disease, primarily tubular proteinuria and dense lymphocytic tubulointerstitial infiltrates predominantly composed of CD8 T cells.

MalaCards based summary : Diffuse Infiltrative Lymphocytosis Syndrome is related to panuveitis and mononeuritis multiplex. An important gene associated with Diffuse Infiltrative Lymphocytosis Syndrome is CD8A (CD8a Molecule), and among its related pathways/superpathways are Cell adhesion molecules (CAMs) and Apoptosis-related network due to altered Notch3 in ovarian cancer. Affiliated tissues include kidney, t cells and salivary gland.

Wikipedia : 74 Diffuse infiltrative lymphocytosis syndrome occurs in HIV positive patients with low CD4... more...

Related Diseases for Diffuse Infiltrative Lymphocytosis Syndrome

Diseases related to Diffuse Infiltrative Lymphocytosis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 202)
# Related Disease Score Top Affiliating Genes
1 panuveitis 30.3 CD8A CD4
2 mononeuritis multiplex 29.8 TRIM21 SSB CD4
3 polyclonal hypergammaglobulinemia 29.8 TRIM21 SSB CD4
4 keratoconjunctivitis sicca 29.8 TRIM21 SSB CD4
5 sjogren syndrome 29.5 TRIM21 SSB ITGAL
6 xerophthalmia 29.4 TRIM21 SSB CD8A CD4
7 sialadenitis 29.4 TRIM21 SSB CD8A CD4
8 neuropathy 10.3
9 cork-handlers' disease 10.3 CD8A CD4
10 ventilation pneumonitis 10.3 CD8A CD4
11 diabetes mellitus, insulin-dependent, 23 10.3 CD8A CD4
12 autoimmune lymphoproliferative syndrome, type iia 10.3 CD8A CD4
13 early yaws 10.3 CD8A CD4
14 bird fancier's lung 10.3 CD8A CD4
15 parapsoriasis 10.3 CD8A CD4
16 norwegian scabies 10.3 CD8A CD4
17 skin sarcoidosis 10.3 CD8A CD4
18 variola major 10.3 CD8A CD4
19 follicular mucinosis 10.3 CD8A CD4
20 viral exanthem 10.3 CD8A CD4
21 tertiary syphilis 10.3 CD8A CD4
22 syphilis 10.3 CD8A CD4
23 spongiotic dermatitis 10.3 CD8A CD4
24 acute retinal necrosis syndrome 10.3 CD8A CD4
25 invasive malignant thymoma 10.3 CD8A CD4
26 metal allergy 10.3 CD8A CD4
27 cerebritis 10.3 CD8A CD4
28 granulomatous hepatitis 10.3 CD8A CD4
29 acute interstitial pneumonia 10.3 CD8A CD4
30 west nile encephalitis 10.3 CD8A CD4
31 oral hairy leukoplakia 10.3 CD8A CD4
32 superficial basal cell carcinoma 10.3 CD8A CD4
33 secondary syphilis 10.3 CD8A CD4
34 glanders 10.3 CD8A CD4
35 nickel allergic contact dermatitis 10.3 CD8A CD4
36 west nile fever 10.3 CD8A CD4
37 neurosarcoidosis 10.3 CD8A CD4
38 esophageal candidiasis 10.3 CD8A CD4
39 myeloid and lymphoid neoplasms associated with fgfr1 abnormalities 10.3 CD8A CD4
40 cardiomyopathy, familial hypertrophic, 9 10.3 CD8A CD4
41 oral tuberculosis 10.3 CD8A CD4
42 pneumonic tularemia 10.3 CD8A CD4
43 tularemia 10.3 CD8A CD4
44 farmer's lung 10.3 CD8A CD4
45 pneumonic plague 10.3 CD8A CD4
46 plague 10.3 CD8A CD4
47 adenoid hypertrophy 10.3 CD8A CD4
48 dacryoadenitis 10.3 CD8A CD4
49 duodenitis 10.3 CD8A CD4
50 combat disorder 10.3 CD8A CD4

Graphical network of the top 20 diseases related to Diffuse Infiltrative Lymphocytosis Syndrome:



Diseases related to Diffuse Infiltrative Lymphocytosis Syndrome

Symptoms & Phenotypes for Diffuse Infiltrative Lymphocytosis Syndrome

Drugs & Therapeutics for Diffuse Infiltrative Lymphocytosis Syndrome

Search Clinical Trials , NIH Clinical Center for Diffuse Infiltrative Lymphocytosis Syndrome

Genetic Tests for Diffuse Infiltrative Lymphocytosis Syndrome

Anatomical Context for Diffuse Infiltrative Lymphocytosis Syndrome

MalaCards organs/tissues related to Diffuse Infiltrative Lymphocytosis Syndrome:

40
Kidney, T Cells, Salivary Gland, Skeletal Muscle

Publications for Diffuse Infiltrative Lymphocytosis Syndrome

Articles related to Diffuse Infiltrative Lymphocytosis Syndrome:

(show top 50) (show all 72)
# Title Authors PMID Year
1
Risk of Diffuse Infiltrative Lymphocytosis Syndrome in HIV-Infected Patients: A Nationwide Population-Based Cohort Study. 61
29995702 2018
2
Diffuse connective tissue disorders in HIV-infected patients. 61
32185316 2018
3
The diffuse infiltrative lymphocytosis syndrome (DILS). A comprehensive review. 61
25660200 2015
4
A case of HIV-associated diffuse infiltrative lymphocytosis syndrome simulating primary Sjögren syndrome and BALT Lymphoma. 61
25340658 2015
5
Benign lymphoepithelial cysts of parotid and submandibular glands in a HIV-positive patient. 61
26097320 2015
6
Musculoskeletal and rheumatological disorders in HIV infection: Experience in a tertiary referral center. 61
24339461 2013
7
Polyneuropathy associated with the diffuse infiltrative lymphocytosis syndrome. 61
22544447 2012
8
Acute interstitial nephritis with predominant plasmacytic infiltration in patients with HIV-1 infection. 61
22342319 2012
9
Evolving spectrum of HIV-associated nephropathy. 61
23208246 2012
10
Primary Sjögren syndrome in a 2-year-old patient: role of the dentist in diagnosis and dental management with a 6-year follow-up. 61
21623979 2011
11
Atypical nervous system manifestations of HIV. 61
21964844 2011
12
Diffuse infiltrative lymphocytosis syndrome presenting as reversible acute kidney injury associated with Gram-negative bacterial infection in patients with newly diagnosed HIV infection. 61
21295898 2011
13
Viruses and salivary gland disease (SGD): lessons from HIV SGD. 61
21441486 2011
14
[Diffuse infiltrative lymphocytosis syndrome: another cause of acute renal failure in the HIV-infected patient]. 61
20880610 2010
15
HIV lumbosacral radiculoplexus neuropathy mimicking lymphoma: diffuse infiltrative lymphocytosis syndrome (DILS) restricted to nerve? 61
19882634 2010
16
Radiology case of the month. Immunocompromised with puffy cheeks. Diffuse infiltrative lymphocytosis syndrome. 61
20108824 2009
17
Rheumatic manifestations associated with HIV in the highly active antiretroviral therapy era. 61
19444116 2009
18
Acute kidney injury in patients with human immunodeficiency virus infection. 61
19005305 2008
19
Rheumatic conditions in human immunodeficiency virus infection. 61
18413346 2008
20
A case of acute renal failure associated with diffuse infiltrative lymphocytosis syndrome. 61
18227804 2008
21
Rheumatic manifestations of human immunodeficiency virus infection. 61
18281864 2008
22
Distinctive rheumatic manifestations in 98 patients with human immunodeficiency virus infection in China. 61
17659750 2007
23
Diffuse infiltrative CD8+ lymphocytosis syndrome: review of the literature and report of a case. 61
18019812 2007
24
Nephropathy associated with the diffuse infiltrative lymphocytosis syndrome. 61
17361111 2007
25
[Diffuse infiltrative lymphocytosis syndrome (DILS) associated with HIV-1 infection: first Senegalese case report]. 61
19097397 2007
26
Infection and musculoskeletal conditions: Rheumatologic complications of HIV infection. 61
17127202 2006
27
Changing spectrum of the diffuse infiltrative lymphocytosis syndrome. 61
16739215 2006
28
Human immunodeficiency virus-associated peripheral neuropathies. 61
16471077 2006
29
[Muscular complications of human immunodeficiency virus (HIV) infection in the era of effective anti-retroviral therapy]. 61
16446625 2006
30
Skeletal muscle involvement in human immunodeficiency virus (HIV)-infected patients in the era of highly active antiretroviral therapy (HAART). 61
15902690 2005
31
Upper respiratory tract involvement in the course of diffuse infiltrative lymphocytosis syndrome in HIV-1-infected patients: report of 2 cases. 61
15983907 2005
32
Bilateral panuveitis in HIV-1-infected patients with CD8 lymphocytosis. 61
16159723 2005
33
Selected rare, noninfectious syndromes associated with HIV infection. 61
16082058 2005
34
Neuropathology of HIV/AIDS with an overview of the Indian scene. 61
15817957 2005
35
Myositis in infiltrative lymphocytosis syndrome: clinicopathological observations and treatment. 61
15482959 2004
36
Diffuse infiltrative lymphocytosis syndrome. 61
14978700 2004
37
Histopathological analysis and demonstration of EBV and HIV p-24 antigen but not CMV expression in labial minor salivary glands of HIV patients affected by diffuse infiltrative lymphocytosis syndrome. 61
12846790 2003
38
Human immunodeficiency virus-associated polymyositis: a longitudinal study of outcome. 61
12687507 2003
39
Sicca syndrome in patients infected with human immunodeficiency virus-1. 61
24384002 2002
40
Diagnosis of diffuse CD8+ lymphocytosis syndrome in HIV-infected patients. 61
12402804 2002
41
HIV-associated neuropathies: role of HIV-1, CMV, and other viruses. 61
11293803 2001
42
Characteristics of salivary diffuse infiltrative lymphocytosis syndrome in West Africa. 61
11100056 2000
43
The changing spectrum of rheumatic disease in human immunodeficiency virus infection. 61
11124280 2000
44
Ocular manifestations of infection with the human immunodeficiency virus in an African pediatric population. 61
11262656 2000
45
[Peripheral nerve diseases and myopathies associated with HIV infection]. 61
10919138 2000
46
HIV-associated peripheral neuropathy: epidemiology, pathophysiology and treatment. 61
10882161 2000
47
Benign monoclonal expansion of CD8+ lymphocytes in HIV infection. 61
10823134 2000
48
HIV-associated parotid lymphoepithelial cysts. 61
10203903 1999
49
Diffuse infiltrative lymphocytosis syndrome in a patient with anti-52-kd Ro/SSA and human immunodeficiency virus type 1. 61
10088785 1999
50
Intraocular inflammation and the diffuse infiltrative lymphocytosis syndrome. 61
9744387 1998

Variations for Diffuse Infiltrative Lymphocytosis Syndrome

Expression for Diffuse Infiltrative Lymphocytosis Syndrome

Search GEO for disease gene expression data for Diffuse Infiltrative Lymphocytosis Syndrome.

Pathways for Diffuse Infiltrative Lymphocytosis Syndrome

Pathways related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.3 ITGAL CD8A CD4
3 10.86 ITGAL CD8A CD4
4 10.74 CD8A CD4

GO Terms for Diffuse Infiltrative Lymphocytosis Syndrome

Biological processes related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.33 TNFRSF10B CD8A CD4
2 T cell activation GO:0042110 9.26 CD8A CD4
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.13 TRIM21 TNFRSF10B CD4
4 positive regulation of viral entry into host cell GO:0046598 8.62 TRIM21 CD4

Molecular functions related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 coreceptor activity GO:0015026 8.62 CD8A CD4

Sources for Diffuse Infiltrative Lymphocytosis Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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