MCID: DFF007
MIFTS: 32

Diffuse Infiltrative Lymphocytosis Syndrome

Categories: Immune diseases

Aliases & Classifications for Diffuse Infiltrative Lymphocytosis Syndrome

MalaCards integrated aliases for Diffuse Infiltrative Lymphocytosis Syndrome:

Name: Diffuse Infiltrative Lymphocytosis Syndrome 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6677
NCIt 50 C35699
SNOMED-CT 68 449784008
UMLS 73 C1333292

Summaries for Diffuse Infiltrative Lymphocytosis Syndrome

Disease Ontology : 12 A syndrome that occurs in human immunodeficiency virus (HIV) positive patients, which is accompanied by decreased kidney function. The spectrum of kidney involvement includes acute or chronic kidney disease, primarily tubular proteinuria and dense lymphocytic tubulointerstitial infiltrates predominantly composed of CD8 T cells.

MalaCards based summary : Diffuse Infiltrative Lymphocytosis Syndrome is related to interval angle-closure glaucoma and adult oligodendroglioma. An important gene associated with Diffuse Infiltrative Lymphocytosis Syndrome is TNFRSF21 (TNF Receptor Superfamily Member 21), and among its related pathways/superpathways are Immune response Role of DAP12 receptors in NK cells and Phagosome. Affiliated tissues include kidney, t cells and salivary gland, and related phenotypes are hematopoietic system and immune system

Wikipedia : 76 Diffuse Infiltrative Lymphocytosis Syndrome occurs in HIV positive patients with low CD4... more...

Related Diseases for Diffuse Infiltrative Lymphocytosis Syndrome

Diseases related to Diffuse Infiltrative Lymphocytosis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 interval angle-closure glaucoma 10.7 IDH1 IDH2
2 adult oligodendroglioma 10.7 IDH1 IDH2
3 enchondroma 10.7 IDH1 IDH2
4 intracranial chondrosarcoma 10.7 IDH1 IDH2
5 plexiform schwannoma 10.7 B3GAT1 CDSN
6 diffuse scleroderma 10.7 TNFRSF10B TRIM21
7 xerophthalmia 10.7 CDSN TRIM21
8 heart block, congenital 10.7 CDSN TRIM21
9 cytogenetically normal acute myeloid leukemia 10.7 IDH1 IDH2
10 chondroblastic osteosarcoma 10.7 IDH1 IDH2
11 intraductal papilloma 10.7 IDH1 IDH2
12 multiple enchondromatosis, maffucci type 10.7 IDH1 IDH2
13 pilocytic astrocytoma of cerebellum 10.6 IDH1 IDH2
14 spindle cell hemangioma 10.6 IDH1 IDH2
15 glioma susceptibility 1 10.6 IDH1 IDH2
16 periosteal chondrosarcoma 10.5 IDH1 IDH2
17 adult astrocytic tumour 10.5 IDH1 IDH2
18 fibrillary astrocytoma 10.5 IDH1 IDH2
19 undifferentiated pleomorphic sarcoma 10.4 IDH1 IDH2
20 iridocyclitis 10.4 MRAP TNFRSF10B
21 salivary gland disease 10.4 CDSN TRIM21
22 guttate psoriasis 10.4 CDSN ITGAL
23 spastic paraplegia 32, autosomal recessive 10.3 B3GAT1 FCGR3A FCGR3B
24 chronic nk-cell lymphocytosis 10.3 B3GAT1 FCGR3A FCGR3B
25 pediatric lymphoma 10.3 B3GAT1 FCGR3A FCGR3B
26 transient neonatal neutropenia 10.3 FCGR3A FCGR3B TRIM21
27 invasive malignant thymoma 10.3 CD19 CD38
28 posterior scleritis 10.2 CD19 MRAP
29 neuropathy 10.2
30 b cell prolymphocytic leukemia 10.1 CD19 CD38
31 lymphoma 10.1
32 orbital plasma cell granuloma 10.0 FCGR3A FCGR3B MRAP
33 chronic orbital inflammation 10.0 FCGR3A FCGR3B MRAP
34 peripheral nervous system disease 10.0
35 rheumatic myocarditis 10.0 CD19 FCGR3A FCGR3B
36 human immunodeficiency virus type 1 9.9
37 polyneuropathy 9.9
38 plasma protein metabolism disease 9.8 CD19 CD38
39 poliomyelitis 9.7 FCGR3A FCGR3B
40 solitary osseous plasmacytoma 9.7 CD19 CD38 SDC1
41 benign cephalic histiocytosis 9.7 ITGAL ITGAX
42 gamma heavy chain disease 9.7 CD19 CD38
43 bladder lymphoma 9.7 CD19 ITGAX
44 mature b-cell neoplasm 9.7 CD19 CD38 SDC1
45 lymphocytic vasculitis 9.7 ITGAL ITGAX
46 non-secretory myeloma 9.6 CD38 ITGAX
47 leukemia, acute myeloid 9.6 CD19 CD38 IDH1 IDH2
48 myeloma, multiple 9.1 CD19 CD38 IDH1 IDH2 SDC1
49 lymphoma, non-hodgkin, familial 7.6 CD19 CD38 FCGR3A ITGAL ITGAX SDC1

Graphical network of the top 20 diseases related to Diffuse Infiltrative Lymphocytosis Syndrome:



Diseases related to Diffuse Infiltrative Lymphocytosis Syndrome

Symptoms & Phenotypes for Diffuse Infiltrative Lymphocytosis Syndrome

MGI Mouse Phenotypes related to Diffuse Infiltrative Lymphocytosis Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CARTPT CD19 CD38 FCGR3B IDH1 ITGAL
2 immune system MP:0005387 9.36 ITGAL ITGAX ITGB1 SDC1 TNFRSF21 TRIM21

Drugs & Therapeutics for Diffuse Infiltrative Lymphocytosis Syndrome

Search Clinical Trials , NIH Clinical Center for Diffuse Infiltrative Lymphocytosis Syndrome

Genetic Tests for Diffuse Infiltrative Lymphocytosis Syndrome

Anatomical Context for Diffuse Infiltrative Lymphocytosis Syndrome

MalaCards organs/tissues related to Diffuse Infiltrative Lymphocytosis Syndrome:

41
Kidney, T Cells, Salivary Gland

Publications for Diffuse Infiltrative Lymphocytosis Syndrome

Articles related to Diffuse Infiltrative Lymphocytosis Syndrome:

(show all 25)
# Title Authors Year
1
The diffuse infiltrative lymphocytosis syndrome (DILS). A comprehensive review. ( 25660200 )
2015
2
A case of HIV-associated diffuse infiltrative lymphocytosis syndrome simulating primary SjAPgren Syndrome and BALT Lymphoma. ( 25340658 )
2014
3
Polyneuropathy associated with the diffuse infiltrative lymphocytosis syndrome. ( 22544447 )
2012
4
Diffuse infiltrative lymphocytosis syndrome presenting as reversible acute kidney injury associated with Gram-negative bacterial infection in patients with newly diagnosed HIV infection. ( 21295898 )
2011
5
HIV lumbosacral radiculoplexus neuropathy mimicking lymphoma: diffuse infiltrative lymphocytosis syndrome (DILS) restricted to nerve? ( 19882634 )
2010
6
Radiology case of the month. Immunocompromised with puffy cheeks. Diffuse infiltrative lymphocytosis syndrome. ( 20108824 )
2009
7
A case of acute renal failure associated with diffuse infiltrative lymphocytosis syndrome. ( 18227804 )
2008
8
Nephropathy associated with the diffuse infiltrative lymphocytosis syndrome. ( 17361111 )
2007
9
Changing spectrum of the diffuse infiltrative lymphocytosis syndrome. ( 16739215 )
2006
10
Upper respiratory tract involvement in the course of diffuse infiltrative lymphocytosis syndrome in HIV-1-infected patients: report of 2 cases. ( 15983907 )
2005
11
Diffuse infiltrative lymphocytosis syndrome. ( 14978700 )
2004
12
Histopathological analysis and demonstration of EBV and HIV p-24 antigen but not CMV expression in labial minor salivary glands of HIV patients affected by diffuse infiltrative lymphocytosis syndrome. ( 12846790 )
2003
13
Characteristics of salivary diffuse infiltrative lymphocytosis syndrome in West Africa. ( 11100056 )
2000
14
Diffuse infiltrative lymphocytosis syndrome in a patient with anti-52-kd Ro/SSA and human immunodeficiency virus type 1. ( 10088785 )
1999
15
Prevalence of the diffuse infiltrative lymphocytosis syndrome among human immunodeficiency virus type 1-positive outpatients. ( 9588738 )
1998
16
Neuropathy in diffuse infiltrative lymphocytosis syndrome: an HIV neuropathy, not a lymphoma. ( 9566392 )
1998
17
Intraocular inflammation and the diffuse infiltrative lymphocytosis syndrome. ( 9744387 )
1998
18
The pathogenesis of diffuse infiltrative lymphocytosis syndrome: an AIDS-related peripheral neuropathy. ( 9566362 )
1998
19
Cystic parotid gland enlargement in HIV disease. The diffuse infiltrative lymphocytosis syndrome. ( 9214536 )
1997
20
Peripheral neuropathy in human immunodeficiency virus-infected patients with the diffuse infiltrative lymphocytosis syndrome. ( 9124800 )
1997
21
The diffuse infiltrative lymphocytosis syndrome. Clinical and immunogenetic features in 35 patients. ( 8728042 )
1996
22
Diffuse infiltrative lymphocytosis syndrome in a patient not infected with the human immunodeficiency virus. ( 8775946 )
1996
23
Diffuse infiltrative lymphocytosis syndrome in children and adults infected with HIV-1: a model of rheumatic illness caused by acquired viral infection. ( 1285893 )
1992
24
Diffuse infiltrative lymphocytosis syndrome: a disorder occurring in human immunodeficiency virus-1 infection that may present as a sicca syndrome. ( 1496168 )
1992
25
Diffuse infiltrative lymphocytosis syndrome in human immunodeficiency virus infection--a SjAPgren's-like disease. ( 2041892 )
1991

Variations for Diffuse Infiltrative Lymphocytosis Syndrome

Expression for Diffuse Infiltrative Lymphocytosis Syndrome

Search GEO for disease gene expression data for Diffuse Infiltrative Lymphocytosis Syndrome.

Pathways for Diffuse Infiltrative Lymphocytosis Syndrome

Pathways related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.29 FCGR3A FCGR3B ITGAL TNFRSF10B
2 11.89 FCGR3A FCGR3B ITGB1
3 11.86 ITGAL ITGB1 SDC1
4
Show member pathways
11.85 ITGAL ITGAX ITGB1 SDC1
5 11.69 CD19 FCGR3A ITGAL ITGB1
6
Show member pathways
11.61 ITGAL ITGAX ITGB1 SDC1 TNFRSF10B
7 11.52 CD19 CD38 ITGAX
8 11.39 FCGR3B ITGAL ITGAX ITGB1
9 11.38 ITGAL ITGAX ITGB1
10 11.36 FCGR3A FCGR3B ITGAL
11 11.3 CD19 CD38 SDC1
12 11.3 CD19 ITGAL ITGAX ITGB1
13 11.09 CD19 CD38 ITGAL ITGAX SDC1
14
Show member pathways
10.61 IDH1 IDH2

GO Terms for Diffuse Infiltrative Lymphocytosis Syndrome

Cellular components related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.97 CD19 CD38 FCGR3A FCGR3B IDH1 IDH2
2 cell surface GO:0009986 9.63 CD38 ITGAL ITGAX ITGB1 SDC1 TNFRSF10B
3 secretory granule membrane GO:0030667 9.58 CD38 FCGR3B ITGAX
4 integrin complex GO:0008305 9.13 ITGAL ITGAX ITGB1
5 external side of plasma membrane GO:0009897 9.02 CD19 FCGR3A ITGAX ITGB1 SDC1
6 integral component of membrane GO:0016021 10.15 B3GAT1 CD19 CD38 FCGR3A FCGR3B ITGAL
7 plasma membrane GO:0005886 10.03 CD19 CD38 CDSN FCGR3A FCGR3B ITGAL

Biological processes related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.78 ITGAL SDC1 TNFRSF10B TNFRSF21
2 regulation of immune response GO:0050776 9.56 CD19 FCGR3A ITGAL ITGB1
3 integrin-mediated signaling pathway GO:0007229 9.54 ITGAL ITGAX ITGB1
4 apoptotic signaling pathway GO:0097190 9.5 CD38 TNFRSF10B TNFRSF21
5 leukocyte cell-cell adhesion GO:0007159 9.49 ITGAL ITGB1
6 heterotypic cell-cell adhesion GO:0034113 9.46 ITGAX ITGB1
7 2-oxoglutarate metabolic process GO:0006103 9.43 IDH1 IDH2
8 negative regulation of bone resorption GO:0045779 9.4 CARTPT CD38
9 isocitrate metabolic process GO:0006102 9.16 IDH1 IDH2
10 leukocyte migration GO:0050900 9.02 ITGAL ITGAX ITGB1 SDC1 TNFRSF10B
11 glyoxylate cycle GO:0006097 8.96 IDH1 IDH2

Molecular functions related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-activated receptor activity GO:0005031 9.26 TNFRSF10B TNFRSF21
2 IgG binding GO:0019864 9.16 FCGR3A FCGR3B
3 isocitrate dehydrogenase activity GO:0004448 8.96 IDH1 IDH2
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.62 IDH1 IDH2

Sources for Diffuse Infiltrative Lymphocytosis Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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