MCID: DFF007
MIFTS: 34

Diffuse Infiltrative Lymphocytosis Syndrome

Categories: Immune diseases

Aliases & Classifications for Diffuse Infiltrative Lymphocytosis Syndrome

MalaCards integrated aliases for Diffuse Infiltrative Lymphocytosis Syndrome:

Name: Diffuse Infiltrative Lymphocytosis Syndrome 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:6677
NCIt 51 C35699
UMLS 74 C1333292

Summaries for Diffuse Infiltrative Lymphocytosis Syndrome

Disease Ontology : 12 A syndrome that occurs in human immunodeficiency virus (HIV) positive patients, which is accompanied by decreased kidney function. The spectrum of kidney involvement includes acute or chronic kidney disease, primarily tubular proteinuria and dense lymphocytic tubulointerstitial infiltrates predominantly composed of CD8 T cells.

MalaCards based summary : Diffuse Infiltrative Lymphocytosis Syndrome is related to human immunodeficiency virus type 1 and diffuse scleroderma. An important gene associated with Diffuse Infiltrative Lymphocytosis Syndrome is TNFRSF21 (TNF Receptor Superfamily Member 21), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Akt Signaling. Affiliated tissues include kidney, t cells and myeloid, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 77 Diffuse infiltrative lymphocytosis syndrome occurs in HIV positive patients with low CD4... more...

Related Diseases for Diffuse Infiltrative Lymphocytosis Syndrome

Diseases related to Diffuse Infiltrative Lymphocytosis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
# Related Disease Score Top Affiliating Genes
1 human immunodeficiency virus type 1 29.7 CD28 CD38 CD4 ITGAL
2 diffuse scleroderma 10.3 TNFRSF10B TRIM21
3 interval angle-closure glaucoma 10.3 IDH1 IDH2
4 adult oligodendroglioma 10.3 IDH1 IDH2
5 enchondroma 10.3 IDH1 IDH2
6 intracranial chondrosarcoma 10.3 IDH1 IDH2
7 cytogenetically normal acute myeloid leukemia 10.3 IDH1 IDH2
8 chondroblastic osteosarcoma 10.3 IDH1 IDH2
9 multiple enchondromatosis, maffucci type 10.3 IDH1 IDH2
10 intraductal papilloma 10.3 IDH1 IDH2
11 neuropathy 10.3
12 pilocytic astrocytoma of cerebellum 10.3 IDH1 IDH2
13 spindle cell hemangioma 10.3 IDH1 IDH2
14 periosteal chondrosarcoma 10.3 IDH1 IDH2
15 iridocyclitis 10.2 MRAP TNFRSF10B
16 glioma susceptibility 1 10.2 IDH1 IDH2
17 lymphoma 10.2
18 orbital plasma cell granuloma 10.2 CTLA4 MRAP
19 invasive malignant thymoma 10.2 CD19 CD38
20 adult astrocytic tumour 10.2 IDH1 IDH2
21 posterior scleritis 10.2 CD19 MRAP
22 fibrillary astrocytoma 10.2 IDH1 IDH2
23 chronic orbital inflammation 10.1 CTLA4 MRAP
24 peripheral nervous system disease 10.1
25 b cell prolymphocytic leukemia 10.1 CD19 CD38
26 waldenstroem's macroglobulinemia 10.1 CD19 CD38
27 drug-induced mental disorder 10.1 IDH1 IDH2
28 gamma heavy chain disease 10.1 CD19 CD38
29 drug psychosis 10.0 IDH1 IDH2
30 plasma protein metabolism disease 10.0 CD19 CD38
31 sjogren syndrome 10.0
32 polyneuropathy 10.0
33 human immunodeficiency virus infectious disease 10.0
34 lymphosarcoma 10.0
35 undifferentiated pleomorphic sarcoma 9.9 IDH1 IDH2
36 benign cephalic histiocytosis 9.9 ITGAL ITGAX
37 solitary osseous plasmacytoma 9.9 CD19 CD38 SDC1
38 mature b-cell neoplasm 9.9 CD19 CD38 SDC1
39 leukocyte disease 9.9 CD19 CD38 SDC1
40 bladder lymphoma 9.9 CD19 ITGAX
41 lymphocytic vasculitis 9.9 ITGAL ITGAX
42 mycosis fungoides 9.8 CD28 CTLA4 ITGAL
43 non-secretory myeloma 9.7 CD19 CD38 ITGAX
44 common variable immunodeficiency 9.7 CD19 CD28 CD38 CTLA4
45 myeloma, multiple 9.6 CD19 CD38 IDH1 IDH2 SDC1
46 leukemia, acute myeloid 9.4 CD19 CD38 IDH1 IDH2 ITGAX
47 lymphoma, non-hodgkin, familial 9.1 CD19 CD38 ITGAL ITGAX SDC1

Graphical network of the top 20 diseases related to Diffuse Infiltrative Lymphocytosis Syndrome:



Diseases related to Diffuse Infiltrative Lymphocytosis Syndrome

Symptoms & Phenotypes for Diffuse Infiltrative Lymphocytosis Syndrome

MGI Mouse Phenotypes related to Diffuse Infiltrative Lymphocytosis Syndrome:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.1 CD19 CD28 CD38 CD4 CTLA4 IDH1
2 homeostasis/metabolism MP:0005376 10 CD19 CD28 CD38 CD4 CTLA4 IDH1
3 immune system MP:0005387 9.93 CD19 CD28 CD38 CD4 CTLA4 IDH1
4 integument MP:0010771 9.5 CD19 CD28 CD4 CTLA4 ITGB1 SDC1
5 neoplasm MP:0002006 9.1 CD19 CD28 IDH2 ITGAL ITGB1 SDC1

Drugs & Therapeutics for Diffuse Infiltrative Lymphocytosis Syndrome

Search Clinical Trials , NIH Clinical Center for Diffuse Infiltrative Lymphocytosis Syndrome

Genetic Tests for Diffuse Infiltrative Lymphocytosis Syndrome

Anatomical Context for Diffuse Infiltrative Lymphocytosis Syndrome

MalaCards organs/tissues related to Diffuse Infiltrative Lymphocytosis Syndrome:

42
Kidney, T Cells, Myeloid, B Cells, Salivary Gland, Cerebellum

Publications for Diffuse Infiltrative Lymphocytosis Syndrome

Articles related to Diffuse Infiltrative Lymphocytosis Syndrome:

(show all 26)
# Title Authors Year
1
Risk of Diffuse Infiltrative Lymphocytosis Syndrome in HIV-Infected Patients: A Nationwide Population-Based Cohort Study. ( 29995702 )
2018
2
A case of HIV-associated diffuse infiltrative lymphocytosis syndrome simulating primary Sjögren syndrome and BALT Lymphoma. ( 25340658 )
2015
3
The diffuse infiltrative lymphocytosis syndrome (DILS). A comprehensive review. ( 25660200 )
2015
4
Polyneuropathy associated with the diffuse infiltrative lymphocytosis syndrome. ( 22544447 )
2012
5
Diffuse infiltrative lymphocytosis syndrome presenting as reversible acute kidney injury associated with Gram-negative bacterial infection in patients with newly diagnosed HIV infection. ( 21295898 )
2011
6
HIV lumbosacral radiculoplexus neuropathy mimicking lymphoma: diffuse infiltrative lymphocytosis syndrome (DILS) restricted to nerve? ( 19882634 )
2010
7
Radiology case of the month. Immunocompromised with puffy cheeks. Diffuse infiltrative lymphocytosis syndrome. ( 20108824 )
2009
8
A case of acute renal failure associated with diffuse infiltrative lymphocytosis syndrome. ( 18227804 )
2008
9
Nephropathy associated with the diffuse infiltrative lymphocytosis syndrome. ( 17361111 )
2007
10
Changing spectrum of the diffuse infiltrative lymphocytosis syndrome. ( 16739215 )
2006
11
Upper respiratory tract involvement in the course of diffuse infiltrative lymphocytosis syndrome in HIV-1-infected patients: report of 2 cases. ( 15983907 )
2005
12
Diffuse infiltrative lymphocytosis syndrome. ( 14978700 )
2004
13
Histopathological analysis and demonstration of EBV and HIV p-24 antigen but not CMV expression in labial minor salivary glands of HIV patients affected by diffuse infiltrative lymphocytosis syndrome. ( 12846790 )
2003
14
Characteristics of salivary diffuse infiltrative lymphocytosis syndrome in West Africa. ( 11100056 )
2000
15
Diffuse infiltrative lymphocytosis syndrome in a patient with anti-52-kd Ro/SSA and human immunodeficiency virus type 1. ( 10088785 )
1999
16
The pathogenesis of diffuse infiltrative lymphocytosis syndrome: an AIDS-related peripheral neuropathy. ( 9566362 )
1998
17
Neuropathy in diffuse infiltrative lymphocytosis syndrome: an HIV neuropathy, not a lymphoma. ( 9566392 )
1998
18
Prevalence of the diffuse infiltrative lymphocytosis syndrome among human immunodeficiency virus type 1-positive outpatients. ( 9588738 )
1998
19
Intraocular inflammation and the diffuse infiltrative lymphocytosis syndrome. ( 9744387 )
1998
20
Peripheral neuropathy in human immunodeficiency virus-infected patients with the diffuse infiltrative lymphocytosis syndrome. ( 9124800 )
1997
21
Cystic parotid gland enlargement in HIV disease. The diffuse infiltrative lymphocytosis syndrome. ( 9214536 )
1997
22
The diffuse infiltrative lymphocytosis syndrome. Clinical and immunogenetic features in 35 patients. ( 8728042 )
1996
23
Diffuse infiltrative lymphocytosis syndrome in a patient not infected with the human immunodeficiency virus. ( 8775946 )
1996
24
Diffuse infiltrative lymphocytosis syndrome in children and adults infected with HIV-1: a model of rheumatic illness caused by acquired viral infection. ( 1285893 )
1992
25
Diffuse infiltrative lymphocytosis syndrome: a disorder occurring in human immunodeficiency virus-1 infection that may present as a sicca syndrome. ( 1496168 )
1992
26
Diffuse infiltrative lymphocytosis syndrome in human immunodeficiency virus infection--a Sjögren's-like disease. ( 2041892 )
1991

Variations for Diffuse Infiltrative Lymphocytosis Syndrome

Expression for Diffuse Infiltrative Lymphocytosis Syndrome

Search GEO for disease gene expression data for Diffuse Infiltrative Lymphocytosis Syndrome.

Pathways for Diffuse Infiltrative Lymphocytosis Syndrome

Pathways related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 CD19 CD28 CD4 CTLA4 ITGAL ITGB1
2
Show member pathways
13.19 CD28 CD4 ITGAL ITGAX ITGB1 TNFRSF10B
3
Show member pathways
12.55 ITGAL ITGAX ITGB1 SDC1
4 12.28 CD19 CD28 CD38 CTLA4 TNFRSF10B
5
Show member pathways
11.95 ITGAL ITGAX ITGB1 SDC1
6
Show member pathways
11.91 ITGAL ITGAX ITGB1 SDC1 TNFRSF10B
7 11.88 CD19 ITGAL ITGB1
8 11.72 CD19 CD38 CD4
9 11.71 CD19 ITGAL ITGAX ITGB1
10 11.68 CD28 CTLA4 ITGAL
11 11.64 ITGAL ITGAX ITGB1
12 11.6 CD28 CD4 CTLA4 ITGAL ITGB1 SDC1
13 11.54 CD28 CD4 CTLA4
14 11.49 CD19 CD38 CD4 ITGAX
15 11.42 CD19 ITGAL ITGAX ITGB1
16 11.41 ITGAL ITGAX ITGB1
17 11.23 CD19 CD28 CD38 CD4 ITGAL ITGAX
18 11.18 CD19 CD38 CD4 SDC1
19 11.03 CD28 CD4
20
Show member pathways
10.68 IDH1 IDH2

GO Terms for Diffuse Infiltrative Lymphocytosis Syndrome

Cellular components related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.97 B3GAT1 CD19 CD28 CD38 CD4 CTLA4
2 integral component of plasma membrane GO:0005887 9.91 CD19 CD28 CD4 CTLA4 SDC1 TNFRSF21
3 cell surface GO:0009986 9.56 CD28 CD38 CD4 ITGAL ITGAX ITGB1
4 integrin complex GO:0008305 9.43 ITGAL ITGAX ITGB1
5 protein complex involved in cell adhesion GO:0098636 9.32 CD28 CTLA4
6 external side of plasma membrane GO:0009897 9.17 CD19 CD28 CD4 CTLA4 ITGAX ITGB1
7 membrane GO:0016020 10.22 B3GAT1 CD19 CD28 CD38 CD4 CTLA4
8 plasma membrane GO:0005886 10.15 CD19 CD28 CD38 CD4 CTLA4 ITGAL

Biological processes related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.71 CD4 ITGAX ITGB1 SDC1
2 T cell receptor signaling pathway GO:0050852 9.7 CD28 CD4 TNFRSF21
3 B cell receptor signaling pathway GO:0050853 9.69 CD19 CD38 CTLA4
4 integrin-mediated signaling pathway GO:0007229 9.61 ITGAL ITGAX ITGB1
5 leukocyte cell-cell adhesion GO:0007159 9.57 ITGAL ITGB1
6 heterotypic cell-cell adhesion GO:0034113 9.56 ITGAX ITGB1
7 regulation of defense response to virus by virus GO:0050690 9.55 CD28 CD4
8 2-oxoglutarate metabolic process GO:0006103 9.54 IDH1 IDH2
9 cell surface receptor signaling pathway GO:0007166 9.54 CD28 CD4 TNFRSF10B
10 negative regulation of B cell proliferation GO:0030889 9.49 CTLA4 TNFRSF21
11 regulation of regulatory T cell differentiation GO:0045589 9.48 CD28 CTLA4
12 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.46 CD28 CD4
13 NADP metabolic process GO:0006739 9.32 IDH1 IDH2
14 positive regulation of viral entry into host cell GO:0046598 9.26 CD4 TRIM21
15 isocitrate metabolic process GO:0006102 9.16 IDH1 IDH2
16 leukocyte migration GO:0050900 9.02 ITGAL ITGAX ITGB1 SDC1 TNFRSF10B
17 glyoxylate cycle GO:0006097 8.96 IDH1 IDH2

Molecular functions related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 CD28 CD38 CD4 IDH1 MRAP SDC1
2 signaling receptor activity GO:0038023 9.62 CD4 ITGAX ITGB1 TNFRSF10B
3 coreceptor activity GO:0015026 9.33 CD28 CD4 ITGB1
4 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
5 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Diffuse Infiltrative Lymphocytosis Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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