MCID: DFF007
MIFTS: 35

Diffuse Infiltrative Lymphocytosis Syndrome

Categories: Immune diseases

Aliases & Classifications for Diffuse Infiltrative Lymphocytosis Syndrome

MalaCards integrated aliases for Diffuse Infiltrative Lymphocytosis Syndrome:

Name: Diffuse Infiltrative Lymphocytosis Syndrome 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:6677
NCIt 50 C35699
UMLS 73 C1333292

Summaries for Diffuse Infiltrative Lymphocytosis Syndrome

Disease Ontology : 12 A syndrome that occurs in human immunodeficiency virus (HIV) positive patients, which is accompanied by decreased kidney function. The spectrum of kidney involvement includes acute or chronic kidney disease, primarily tubular proteinuria and dense lymphocytic tubulointerstitial infiltrates predominantly composed of CD8 T cells.

MalaCards based summary : Diffuse Infiltrative Lymphocytosis Syndrome is related to neuropathy and interval angle-closure glaucoma. An important gene associated with Diffuse Infiltrative Lymphocytosis Syndrome is TNFRSF21 (TNF Receptor Superfamily Member 21), and among its related pathways/superpathways are Akt Signaling and Development Angiotensin activation of ERK. Affiliated tissues include kidney, t cells and salivary gland, and related phenotypes are hematopoietic system and immune system

Wikipedia : 76 Diffuse infiltrative lymphocytosis syndrome occurs in HIV positive patients with low CD4... more...

Related Diseases for Diffuse Infiltrative Lymphocytosis Syndrome

Diseases related to Diffuse Infiltrative Lymphocytosis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 neuropathy 10.3
2 interval angle-closure glaucoma 10.2 IDH1 IDH2
3 adult oligodendroglioma 10.2 IDH1 IDH2
4 diffuse scleroderma 10.2 TNFRSF10B TRIM21
5 enchondroma 10.2 IDH1 IDH2
6 intracranial chondrosarcoma 10.2 IDH1 IDH2
7 lymphoma 10.2
8 cytogenetically normal acute myeloid leukemia 10.2 IDH1 IDH2
9 chondroblastic osteosarcoma 10.2 IDH1 IDH2
10 multiple enchondromatosis, maffucci type 10.2 IDH1 IDH2
11 intraductal papilloma 10.2 IDH1 IDH2
12 pilocytic astrocytoma of cerebellum 10.2 IDH1 IDH2
13 spindle cell hemangioma 10.2 IDH1 IDH2
14 periosteal chondrosarcoma 10.2 IDH1 IDH2
15 glioma susceptibility 1 10.2 IDH1 IDH2
16 iridocyclitis 10.2 MRAP TNFRSF10B
17 adult astrocytic tumour 10.2 IDH1 IDH2
18 fibrillary astrocytoma 10.2 IDH1 IDH2
19 drug-induced mental disorder 10.1 IDH1 IDH2
20 subacute cutaneous lupus erythematosus 10.1 TNF TRIM21
21 drug psychosis 10.1 IDH1 IDH2
22 invasive malignant thymoma 10.1 CD19 CD38
23 undifferentiated pleomorphic sarcoma 10.1 IDH1 IDH2
24 human immunodeficiency virus type 1 10.1
25 peripheral nervous system disease 10.1
26 b cell prolymphocytic leukemia 10.1 CD19 CD38
27 waldenstroem's macroglobulinemia 10.1 CD19 CD38
28 juvenile ankylosing spondylitis 10.1 MRAP TNF
29 gamma heavy chain disease 10.1 CD19 CD38
30 scleral disease 10.1 MRAP TNF
31 pustulosis of palm and sole 10.1 MRAP TNF
32 encephalitozoonosis 10.1 CD19 TNF
33 plasma protein metabolism disease 10.1 CD19 CD38
34 transient hypogammaglobulinemia 10.1 CD19 TNF
35 palindromic rheumatism 10.0 MRAP TNF TNFRSF10B
36 sialadenitis 10.0 TNF TRIM21
37 acute salpingitis 10.0 MRAP TNF
38 actinic prurigo 10.0 ITGAL TNF
39 autoimmune disease of musculoskeletal system 10.0 CD19 TNF TRIM21
40 immune system disease 10.0 CD19 TNF TRIM21
41 polyneuropathy 10.0
42 human immunodeficiency virus infectious disease 10.0
43 viral infectious disease 10.0
44 penicilliosis 10.0 ITGAL TNF
45 solitary osseous plasmacytoma 10.0 CD19 CD38 SDC1
46 plasma cell neoplasm 10.0 CD19 CD38 SDC1
47 monoclonal gammopathy of uncertain significance 10.0 CD19 CD38 TNF
48 mature b-cell neoplasm 10.0 CD19 CD38 SDC1
49 bladder lymphoma 10.0 CD19 ITGAX
50 posterior scleritis 9.9 CD19 MRAP TNF

Graphical network of the top 20 diseases related to Diffuse Infiltrative Lymphocytosis Syndrome:



Diseases related to Diffuse Infiltrative Lymphocytosis Syndrome

Symptoms & Phenotypes for Diffuse Infiltrative Lymphocytosis Syndrome

MGI Mouse Phenotypes related to Diffuse Infiltrative Lymphocytosis Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.85 CD19 CD38 IDH1 ITGAL ITGAX ITGB1
2 immune system MP:0005387 9.65 CD19 CD38 IDH1 ITGAL ITGAX ITGB1
3 neoplasm MP:0002006 9.1 CD19 IDH2 ITGAL ITGB1 SDC1 TNF

Drugs & Therapeutics for Diffuse Infiltrative Lymphocytosis Syndrome

Search Clinical Trials , NIH Clinical Center for Diffuse Infiltrative Lymphocytosis Syndrome

Genetic Tests for Diffuse Infiltrative Lymphocytosis Syndrome

Anatomical Context for Diffuse Infiltrative Lymphocytosis Syndrome

MalaCards organs/tissues related to Diffuse Infiltrative Lymphocytosis Syndrome:

41
Kidney, T Cells, Salivary Gland, Tongue, B Cells, Cerebellum, Myeloid

Publications for Diffuse Infiltrative Lymphocytosis Syndrome

Articles related to Diffuse Infiltrative Lymphocytosis Syndrome:

(show all 26)
# Title Authors Year
1
Risk of Diffuse Infiltrative Lymphocytosis Syndrome in HIV-Infected Patients: A Nationwide Population-Based Cohort Study. ( 29995702 )
2018
2
The diffuse infiltrative lymphocytosis syndrome (DILS). A comprehensive review. ( 25660200 )
2015
3
A case of HIV-associated diffuse infiltrative lymphocytosis syndrome simulating primary SjAPgren Syndrome and BALT Lymphoma. ( 25340658 )
2014
4
Polyneuropathy associated with the diffuse infiltrative lymphocytosis syndrome. ( 22544447 )
2012
5
Diffuse infiltrative lymphocytosis syndrome presenting as reversible acute kidney injury associated with Gram-negative bacterial infection in patients with newly diagnosed HIV infection. ( 21295898 )
2011
6
HIV lumbosacral radiculoplexus neuropathy mimicking lymphoma: diffuse infiltrative lymphocytosis syndrome (DILS) restricted to nerve? ( 19882634 )
2010
7
Radiology case of the month. Immunocompromised with puffy cheeks. Diffuse infiltrative lymphocytosis syndrome. ( 20108824 )
2009
8
A case of acute renal failure associated with diffuse infiltrative lymphocytosis syndrome. ( 18227804 )
2008
9
Nephropathy associated with the diffuse infiltrative lymphocytosis syndrome. ( 17361111 )
2007
10
Changing spectrum of the diffuse infiltrative lymphocytosis syndrome. ( 16739215 )
2006
11
Upper respiratory tract involvement in the course of diffuse infiltrative lymphocytosis syndrome in HIV-1-infected patients: report of 2 cases. ( 15983907 )
2005
12
Diffuse infiltrative lymphocytosis syndrome. ( 14978700 )
2004
13
Histopathological analysis and demonstration of EBV and HIV p-24 antigen but not CMV expression in labial minor salivary glands of HIV patients affected by diffuse infiltrative lymphocytosis syndrome. ( 12846790 )
2003
14
Characteristics of salivary diffuse infiltrative lymphocytosis syndrome in West Africa. ( 11100056 )
2000
15
Diffuse infiltrative lymphocytosis syndrome in a patient with anti-52-kd Ro/SSA and human immunodeficiency virus type 1. ( 10088785 )
1999
16
Prevalence of the diffuse infiltrative lymphocytosis syndrome among human immunodeficiency virus type 1-positive outpatients. ( 9588738 )
1998
17
Neuropathy in diffuse infiltrative lymphocytosis syndrome: an HIV neuropathy, not a lymphoma. ( 9566392 )
1998
18
Intraocular inflammation and the diffuse infiltrative lymphocytosis syndrome. ( 9744387 )
1998
19
The pathogenesis of diffuse infiltrative lymphocytosis syndrome: an AIDS-related peripheral neuropathy. ( 9566362 )
1998
20
Cystic parotid gland enlargement in HIV disease. The diffuse infiltrative lymphocytosis syndrome. ( 9214536 )
1997
21
Peripheral neuropathy in human immunodeficiency virus-infected patients with the diffuse infiltrative lymphocytosis syndrome. ( 9124800 )
1997
22
The diffuse infiltrative lymphocytosis syndrome. Clinical and immunogenetic features in 35 patients. ( 8728042 )
1996
23
Diffuse infiltrative lymphocytosis syndrome in a patient not infected with the human immunodeficiency virus. ( 8775946 )
1996
24
Diffuse infiltrative lymphocytosis syndrome in children and adults infected with HIV-1: a model of rheumatic illness caused by acquired viral infection. ( 1285893 )
1992
25
Diffuse infiltrative lymphocytosis syndrome: a disorder occurring in human immunodeficiency virus-1 infection that may present as a sicca syndrome. ( 1496168 )
1992
26
Diffuse infiltrative lymphocytosis syndrome in human immunodeficiency virus infection--a SjAPgren's-like disease. ( 2041892 )
1991

Variations for Diffuse Infiltrative Lymphocytosis Syndrome

Expression for Diffuse Infiltrative Lymphocytosis Syndrome

Search GEO for disease gene expression data for Diffuse Infiltrative Lymphocytosis Syndrome.

Pathways for Diffuse Infiltrative Lymphocytosis Syndrome

Pathways related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 ITGAL ITGAX ITGB1 TNF TNFRSF10B TNFRSF21
2
Show member pathways
12.72 ITGAL ITGB1 TNF TNFRSF10B TNFRSF21
3
Show member pathways
12.56 ITGAL ITGAX ITGB1 SDC1
4
Show member pathways
12.43 ITGB1 TNF TNFRSF10B TNFRSF21
5 12.35 CD19 CD38 TNF TNFRSF10B
6 12.05 TNF TNFRSF10B TNFRSF21
7 11.95 ITGAL ITGAX ITGB1
8 11.93 ITGAL ITGB1 SDC1
9 11.88 CD19 ITGAL ITGB1
10
Show member pathways
11.85 ITGAL ITGAX ITGB1 SDC1
11
Show member pathways
11.84 ITGB1 SDC1 TNF
12 11.78 ITGAX ITGB1 TNF
13 11.67 CD19 CD38 TNF
14
Show member pathways
11.61 ITGAL ITGAX ITGB1 SDC1 TNFRSF10B
15 11.6 ITGAL ITGAX ITGB1
16 11.56 CD19 ITGAL ITGAX ITGB1
17 11.41 ITGAL ITGAX ITGB1
19 11.34 ITGAL ITGAX ITGB1
20 11.33 CD19 CD38 SDC1
21 11.33 CD19 CD38 ITGAX TNF
22 11.3 CD19 ITGAL ITGAX ITGB1
23 11.27 ITGAL SDC1 TNF
24 11.16 CD19 CD38 ITGAL ITGAX SDC1 TNF
25
Show member pathways
10.64 IDH1 IDH2

GO Terms for Diffuse Infiltrative Lymphocytosis Syndrome

Cellular components related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 CD19 CD38 IDH1 IDH2 ITGAL ITGB1
2 external side of plasma membrane GO:0009897 9.55 CD19 ITGAX ITGB1 SDC1 TNF
3 cell surface GO:0009986 9.17 CD38 ITGAL ITGAX ITGB1 SDC1 TNF
4 integrin complex GO:0008305 9.13 ITGAL ITGAX ITGB1
5 plasma membrane GO:0005886 10.02 CD19 CD38 ITGAL ITGAX ITGB1 MRAP
6 integral component of membrane GO:0016021 10 B3GAT1 CD19 CD38 ITGAL ITGAX ITGB1

Biological processes related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.67 ITGAX ITGB1 SDC1 TNF
2 positive regulation of protein kinase B signaling GO:0051897 9.65 CD19 ITGB1 TNF
3 integrin-mediated signaling pathway GO:0007229 9.58 ITGAL ITGAX ITGB1
4 extracellular matrix organization GO:0030198 9.56 ITGAL ITGAX ITGB1 TNF
5 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.52 TNF TNFRSF10B
6 leukocyte cell-cell adhesion GO:0007159 9.51 ITGAL ITGB1
7 heterotypic cell-cell adhesion GO:0034113 9.49 ITGAX ITGB1
8 2-oxoglutarate metabolic process GO:0006103 9.46 IDH1 IDH2
9 leukocyte tethering or rolling GO:0050901 9.43 ITGB1 TNF
10 NADP metabolic process GO:0006739 9.32 IDH1 IDH2
11 isocitrate metabolic process GO:0006102 9.16 IDH1 IDH2
12 leukocyte migration GO:0050900 9.1 ITGAL ITGAX ITGB1 SDC1 TNF TNFRSF10B
13 glyoxylate cycle GO:0006097 8.96 IDH1 IDH2

Molecular functions related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.63 CD38 IDH1 MRAP SDC1 TNF TRIM21
2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.26 IDH1 IDH2
3 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH1 IDH2
4 isocitrate dehydrogenase activity GO:0004448 8.62 IDH1 IDH2

Sources for Diffuse Infiltrative Lymphocytosis Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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