MCID: DFF007
MIFTS: 33

Diffuse Infiltrative Lymphocytosis Syndrome

Categories: Immune diseases

Aliases & Classifications for Diffuse Infiltrative Lymphocytosis Syndrome

MalaCards integrated aliases for Diffuse Infiltrative Lymphocytosis Syndrome:

Name: Diffuse Infiltrative Lymphocytosis Syndrome 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:6677
NCIt 50 C35699
UMLS 72 C1333292

Summaries for Diffuse Infiltrative Lymphocytosis Syndrome

Disease Ontology : 12 A syndrome that occurs in human immunodeficiency virus (HIV) positive patients, which is accompanied by decreased kidney function. The spectrum of kidney involvement includes acute or chronic kidney disease, primarily tubular proteinuria and dense lymphocytic tubulointerstitial infiltrates predominantly composed of CD8 T cells.

MalaCards based summary : Diffuse Infiltrative Lymphocytosis Syndrome is related to polyclonal hypergammaglobulinemia and human immunodeficiency virus type 1. An important gene associated with Diffuse Infiltrative Lymphocytosis Syndrome is CD8A (CD8a Molecule), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include kidney, t cells and salivary gland, and related phenotypes are hematopoietic system and endocrine/exocrine gland

Wikipedia : 75 Diffuse infiltrative lymphocytosis syndrome occurs in HIV positive patients with low CD4... more...

Related Diseases for Diffuse Infiltrative Lymphocytosis Syndrome

Diseases related to Diffuse Infiltrative Lymphocytosis Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 polyclonal hypergammaglobulinemia 30.9 CD8A CD4
2 human immunodeficiency virus type 1 29.2 ITGAL CD4 CD38 CD28
3 metal allergy 10.7 CD8A CD4
4 interval angle-closure glaucoma 10.5 IDH2 IDH1
5 diffuse scleroderma 10.5 TRIM21 TNFRSF10B
6 enchondroma 10.5 IDH2 IDH1
7 adult oligodendroglioma 10.5 IDH2 IDH1
8 intracranial chondrosarcoma 10.5 IDH2 IDH1
9 cytogenetically normal acute myeloid leukemia 10.5 IDH2 IDH1
10 chondroblastic osteosarcoma 10.5 IDH2 IDH1
11 intraductal papilloma 10.4 IDH2 IDH1
12 multiple enchondromatosis, maffucci type 10.4 IDH2 IDH1
13 spindle cell hemangioma 10.4 IDH2 IDH1
14 pilocytic astrocytoma of cerebellum 10.4 IDH2 IDH1
15 neuropathy 10.3
16 periosteal chondrosarcoma 10.3 IDH2 IDH1
17 immune deficiency disease 10.3
18 glioma susceptibility 1 10.3 IDH2 IDH1
19 polyneuropathy 10.2
20 peripheral nervous system disease 10.2
21 fibrillary astrocytoma 10.2 IDH2 IDH1
22 sjogren syndrome 10.1
23 acute kidney failure 10.1
24 kidney disease 10.1
25 b-cell lymphoma 10.1
26 transient neonatal neutropenia 10.1 TRIM21 FCGR3B FCGR3A
27 adult astrocytic tumour 10.1 IDH2 IDH1
28 lymphoid interstitial pneumonia 10.0 TRIM21 CD8A
29 graft-versus-host disease 10.0
30 lymphoma 10.0
31 igg4-related disease 10.0
32 xerophthalmia 10.0
33 sialadenitis 10.0
34 bacterial infectious disease 10.0
35 interstitial nephritis 10.0
36 nephrotic syndrome 10.0
37 panuveitis 10.0
38 aseptic meningitis 10.0
39 neutropenia 10.0
40 keratoconjunctivitis sicca 10.0
41 uveitis 10.0
42 mononeuritis multiplex 10.0
43 polyradiculoneuropathy 10.0
44 acquired immunodeficiency syndrome 10.0
45 axonal neuropathy 10.0
46 lymphosarcoma 10.0
47 polymyositis 10.0
48 benign cephalic histiocytosis 9.8 ITGAX ITGAL
49 solitary osseous plasmacytoma 9.8 SDC1 CD38
50 lymphocytic vasculitis 9.8 ITGAX ITGAL

Graphical network of the top 20 diseases related to Diffuse Infiltrative Lymphocytosis Syndrome:



Diseases related to Diffuse Infiltrative Lymphocytosis Syndrome

Symptoms & Phenotypes for Diffuse Infiltrative Lymphocytosis Syndrome

MGI Mouse Phenotypes related to Diffuse Infiltrative Lymphocytosis Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10 CARTPT CD28 CD38 CD4 CD8A CTLA4
2 endocrine/exocrine gland MP:0005379 9.86 CARTPT CD28 CD38 CD4 CD8A CTLA4
3 homeostasis/metabolism MP:0005376 9.77 CARTPT CD28 CD38 CD4 CTLA4 FCGR3B
4 immune system MP:0005387 9.47 CARTPT CD28 CD38 CD4 CD8A CTLA4

Drugs & Therapeutics for Diffuse Infiltrative Lymphocytosis Syndrome

Search Clinical Trials , NIH Clinical Center for Diffuse Infiltrative Lymphocytosis Syndrome

Genetic Tests for Diffuse Infiltrative Lymphocytosis Syndrome

Anatomical Context for Diffuse Infiltrative Lymphocytosis Syndrome

MalaCards organs/tissues related to Diffuse Infiltrative Lymphocytosis Syndrome:

41
Kidney, T Cells, Salivary Gland, Skeletal Muscle

Publications for Diffuse Infiltrative Lymphocytosis Syndrome

Articles related to Diffuse Infiltrative Lymphocytosis Syndrome:

(show top 50) (show all 71)
# Title Authors PMID Year
1
Risk of Diffuse Infiltrative Lymphocytosis Syndrome in HIV-Infected Patients: A Nationwide Population-Based Cohort Study. 38
29995702 2018
2
The diffuse infiltrative lymphocytosis syndrome (DILS). A comprehensive review. 38
25660200 2015
3
Benign lymphoepithelial cysts of parotid and submandibular glands in a HIV-positive patient. 38
26097320 2015
4
A case of HIV-associated diffuse infiltrative lymphocytosis syndrome simulating primary Sjögren syndrome and BALT Lymphoma. 38
25340658 2015
5
Musculoskeletal and rheumatological disorders in HIV infection: Experience in a tertiary referral center. 38
24339461 2013
6
Polyneuropathy associated with the diffuse infiltrative lymphocytosis syndrome. 38
22544447 2012
7
Acute interstitial nephritis with predominant plasmacytic infiltration in patients with HIV-1 infection. 38
22342319 2012
8
Evolving spectrum of HIV-associated nephropathy. 38
23208246 2012
9
Primary Sjögren syndrome in a 2-year-old patient: role of the dentist in diagnosis and dental management with a 6-year follow-up. 38
21623979 2011
10
Atypical nervous system manifestations of HIV. 38
21964844 2011
11
Diffuse infiltrative lymphocytosis syndrome presenting as reversible acute kidney injury associated with Gram-negative bacterial infection in patients with newly diagnosed HIV infection. 38
21295898 2011
12
Viruses and salivary gland disease (SGD): lessons from HIV SGD. 38
21441486 2011
13
[Diffuse infiltrative lymphocytosis syndrome: another cause of acute renal failure in the HIV-infected patient]. 38
20880610 2010
14
HIV lumbosacral radiculoplexus neuropathy mimicking lymphoma: diffuse infiltrative lymphocytosis syndrome (DILS) restricted to nerve? 38
19882634 2010
15
Radiology case of the month. Immunocompromised with puffy cheeks. Diffuse infiltrative lymphocytosis syndrome. 38
20108824 2009
16
Rheumatic manifestations associated with HIV in the highly active antiretroviral therapy era. 38
19444116 2009
17
Acute kidney injury in patients with human immunodeficiency virus infection. 38
19005305 2008
18
Rheumatic conditions in human immunodeficiency virus infection. 38
18413346 2008
19
A case of acute renal failure associated with diffuse infiltrative lymphocytosis syndrome. 38
18227804 2008
20
Rheumatic manifestations of human immunodeficiency virus infection. 38
18281864 2008
21
Distinctive rheumatic manifestations in 98 patients with human immunodeficiency virus infection in China. 38
17659750 2007
22
Diffuse infiltrative CD8+ lymphocytosis syndrome: review of the literature and report of a case. 38
18019812 2007
23
Nephropathy associated with the diffuse infiltrative lymphocytosis syndrome. 38
17361111 2007
24
[Diffuse infiltrative lymphocytosis syndrome (DILS) associated with HIV-1 infection: first Senegalese case report]. 38
19097397 2007
25
Infection and musculoskeletal conditions: Rheumatologic complications of HIV infection. 38
17127202 2006
26
Changing spectrum of the diffuse infiltrative lymphocytosis syndrome. 38
16739215 2006
27
Human immunodeficiency virus-associated peripheral neuropathies. 38
16471077 2006
28
[Muscular complications of human immunodeficiency virus (HIV) infection in the era of effective anti-retroviral therapy]. 38
16446625 2006
29
Skeletal muscle involvement in human immunodeficiency virus (HIV)-infected patients in the era of highly active antiretroviral therapy (HAART). 38
15902690 2005
30
Upper respiratory tract involvement in the course of diffuse infiltrative lymphocytosis syndrome in HIV-1-infected patients: report of 2 cases. 38
15983907 2005
31
Bilateral panuveitis in HIV-1-infected patients with CD8 lymphocytosis. 38
16159723 2005
32
Selected rare, noninfectious syndromes associated with HIV infection. 38
16082058 2005
33
Neuropathology of HIV/AIDS with an overview of the Indian scene. 38
15817957 2005
34
Myositis in infiltrative lymphocytosis syndrome: clinicopathological observations and treatment. 38
15482959 2004
35
Diffuse infiltrative lymphocytosis syndrome. 38
14978700 2004
36
Histopathological analysis and demonstration of EBV and HIV p-24 antigen but not CMV expression in labial minor salivary glands of HIV patients affected by diffuse infiltrative lymphocytosis syndrome. 38
12846790 2003
37
Human immunodeficiency virus-associated polymyositis: a longitudinal study of outcome. 38
12687507 2003
38
Sicca syndrome in patients infected with human immunodeficiency virus-1. 38
24384002 2002
39
Diagnosis of diffuse CD8+ lymphocytosis syndrome in HIV-infected patients. 38
12402804 2002
40
HIV-associated neuropathies: role of HIV-1, CMV, and other viruses. 38
11293803 2001
41
Characteristics of salivary diffuse infiltrative lymphocytosis syndrome in West Africa. 38
11100056 2000
42
The changing spectrum of rheumatic disease in human immunodeficiency virus infection. 38
11124280 2000
43
Ocular manifestations of infection with the human immunodeficiency virus in an African pediatric population. 38
11262656 2000
44
HIV-associated peripheral neuropathy: epidemiology, pathophysiology and treatment. 38
10882161 2000
45
[Peripheral nerve diseases and myopathies associated with HIV infection]. 38
10919138 2000
46
Benign monoclonal expansion of CD8+ lymphocytes in HIV infection. 38
10823134 2000
47
HIV-associated parotid lymphoepithelial cysts. 38
10203903 1999
48
Diffuse infiltrative lymphocytosis syndrome in a patient with anti-52-kd Ro/SSA and human immunodeficiency virus type 1. 38
10088785 1999
49
Intraocular inflammation and the diffuse infiltrative lymphocytosis syndrome. 38
9744387 1998
50
Renal pathology of human immunodeficiency virus infection. 38
9692353 1998

Variations for Diffuse Infiltrative Lymphocytosis Syndrome

Expression for Diffuse Infiltrative Lymphocytosis Syndrome

Search GEO for disease gene expression data for Diffuse Infiltrative Lymphocytosis Syndrome.

Pathways for Diffuse Infiltrative Lymphocytosis Syndrome

Pathways related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.9 TRIM21 ITGB1 ITGAX ITGAL IDH1 FCGR3B
2
Show member pathways
13.29 TRIM21 ITGB1 ITGAL FCGR3A CTLA4 CD8A
3
Show member pathways
13.28 TNFRSF21 TNFRSF10B ITGB1 ITGAX ITGAL CD4
4
Show member pathways
12.77 ITGAL CTLA4 CD8A CD4 CD28
5
Show member pathways
12.42 CTLA4 CD8A CD4 CD28
6 12.41 MFN2 IDH2 IDH1 CARTPT
7
Show member pathways
12.39 TNFRSF10B ITGAL FCGR3B FCGR3A
8 12.39 TNFRSF10B CTLA4 CD8A CD38 CD28
9
Show member pathways
11.99 SDC1 ITGB1 ITGAX ITGAL
10 11.89 ITGB1 ITGAL FCGR3A CD8A
11
Show member pathways
11.83 CD8A CD4 CD28
12
Show member pathways
11.83 SDC1 ITGB1 FCGR3B FCGR3A
13
Show member pathways
11.8 TNFRSF10B SDC1 ITGB1 ITGAX ITGAL
14 11.77 CD8A CD4 CD38
15 11.74 ITGAL CTLA4 CD28
16 11.71 ITGAL FCGR3B FCGR3A
17 11.66 SDC1 ITGB1 ITGAL CTLA4 CD8A CD4
18 11.6 ITGB1 ITGAX ITGAL FCGR3B
19 11.49 ITGB1 ITGAX ITGAL
20 11.49 ITGAX CD8A CD4 CD38
21 11.44 CTLA4 CD8A CD4 CD28
22 11.42 SDC1 CD4 CD38
23 11.41 CTLA4 CD8A CD4 CD28
24 11.23 SDC1 ITGAX ITGAL CD8A CD4 CD38
25 11.07 CTLA4 CD8A CD28
26
Show member pathways
10.71 IDH2 IDH1

GO Terms for Diffuse Infiltrative Lymphocytosis Syndrome

Cellular components related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule membrane GO:0030667 9.61 ITGAX FCGR3B CD38
2 cell surface GO:0009986 9.56 TNFRSF10B SDC1 ITGB1 ITGAX ITGAL CD4
3 T cell receptor complex GO:0042101 9.46 CD8A CD4
4 integrin complex GO:0008305 9.43 ITGB1 ITGAX ITGAL
5 protein complex involved in cell adhesion GO:0098636 9.32 CTLA4 CD28
6 external side of plasma membrane GO:0009897 9.23 SDC1 ITGB1 ITGAX FCGR3A CTLA4 CD8A
7 membrane GO:0016020 10.28 TNFRSF21 TNFRSF10B SDC1 MFN2 ITGB1 ITGAX
8 plasma membrane GO:0005886 10.18 TNFRSF21 TNFRSF10B SDC1 ITGB1 ITGAX ITGAL
9 extracellular exosome GO:0070062 10.08 SDC1 ITGB1 ITGAL IDH2 IDH1 FCGR3B
10 integral component of membrane GO:0016021 10.03 TNFRSF21 TNFRSF10B SDC1 MFN2 ITGB1 ITGAX

Biological processes related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.83 SDC1 ITGB1 ITGAX CD4
2 cell surface receptor signaling pathway GO:0007166 9.76 TNFRSF10B CD8A CD4 CD28
3 T cell receptor signaling pathway GO:0050852 9.74 TNFRSF21 CD4 CD28
4 integrin-mediated signaling pathway GO:0007229 9.69 ITGB1 ITGAX ITGAL
5 regulation of immune response GO:0050776 9.67 ITGB1 ITGAL FCGR3A CD8A
6 immune response GO:0006955 9.63 FCGR3B FCGR3A CTLA4 CD8A CD4 CD28
7 2-oxoglutarate metabolic process GO:0006103 9.56 IDH2 IDH1
8 regulation of regulatory T cell differentiation GO:0045589 9.55 CTLA4 CD28
9 negative regulation of B cell proliferation GO:0030889 9.54 TNFRSF21 CTLA4
10 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.49 CD4 CD28
11 negative regulation of bone resorption GO:0045779 9.48 CD38 CARTPT
12 positive regulation of viral entry into host cell GO:0046598 9.43 TRIM21 CD4
13 T cell activation GO:0042110 9.43 CD8A CD4 CD28
14 NADP metabolic process GO:0006739 9.4 IDH2 IDH1
15 isocitrate metabolic process GO:0006102 9.32 IDH2 IDH1
16 leukocyte migration GO:0050900 9.02 TNFRSF10B SDC1 ITGB1 ITGAX ITGAL
17 glyoxylate cycle GO:0006097 8.96 IDH2 IDH1

Molecular functions related to Diffuse Infiltrative Lymphocytosis Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.85 TRIM21 SDC1 IDH1 CD4 CD38 CD28
2 signaling receptor activity GO:0038023 9.56 TNFRSF10B ITGB1 ITGAX CD4
3 IgG binding GO:0019864 9.32 FCGR3B FCGR3A
4 isocitrate dehydrogenase activity GO:0004448 9.16 IDH2 IDH1
5 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH2 IDH1
6 coreceptor activity GO:0015026 8.92 ITGB1 CD8A CD4 CD28

Sources for Diffuse Infiltrative Lymphocytosis Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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