MCID: DFF037
MIFTS: 43

Diffuse Intrinsic Pontine Glioma

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Diffuse Intrinsic Pontine Glioma

MalaCards integrated aliases for Diffuse Intrinsic Pontine Glioma:

Name: Diffuse Intrinsic Pontine Glioma 53 59 73
Dipg 53 59
Infiltrative Brainstem Glioma 53

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA497188
UMLS 73 C2986658

Summaries for Diffuse Intrinsic Pontine Glioma

MalaCards based summary : Diffuse Intrinsic Pontine Glioma, also known as dipg, is related to glioma and bone giant cell sarcoma. An important gene associated with Diffuse Intrinsic Pontine Glioma is H3F3A (H3 Histone Family Member 3A), and among its related pathways/superpathways are Signaling by GPCR and Innate Immune System. The drugs Etoposide and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include brain, pons and spinal cord, and related phenotype is G0/1 arrest.

Wikipedia : 76 A diffuse intrinsic pontine glioma (DIPG) is a tumour located in the pons (middle) of the brain stem.... more...

Related Diseases for Diffuse Intrinsic Pontine Glioma

Diseases related to Diffuse Intrinsic Pontine Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 glioma 10.9
2 bone giant cell sarcoma 10.5 H3F3A H3F3B
3 glioma susceptibility 1 10.4 H3F3A HIST1H3A
4 malignant giant cell tumor 10.4 H3F3A H3F3B
5 adult astrocytic tumour 10.3 H3F3A H3F3B
6 brain stem cancer 10.2 H3F3A H3F3B HIST1H3B
7 spinal cord astrocytoma 10.2 H3F3A H3F3B
8 glioblastoma 10.1
9 neonatal respiratory failure 10.0
10 respiratory failure 10.0
11 astrocytoma 10.0
12 endotheliitis 10.0
13 chondroblastoma 9.9 H3F3A H3F3B
14 corneal dystrophy, posterior polymorphous, 1 9.9 HIST1H3B HIST1H3D HIST1H3F HIST1H3G
15 brain stem glioma 8.8 ACVR1 H3F3A H3F3B HIST1H3B HIST1H3D HIST1H3F

Graphical network of the top 20 diseases related to Diffuse Intrinsic Pontine Glioma:



Diseases related to Diffuse Intrinsic Pontine Glioma

Symptoms & Phenotypes for Diffuse Intrinsic Pontine Glioma

GenomeRNAi Phenotypes related to Diffuse Intrinsic Pontine Glioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 G0/1 arrest GR00098-A-2 9.1 HIST1H3B HIST1H3D HIST1H3E HIST1H3G PARP1 PLK1

Drugs & Therapeutics for Diffuse Intrinsic Pontine Glioma

Drugs for Diffuse Intrinsic Pontine Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 123)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3,Phase 1 33419-42-0 36462
2
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
3
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
4
Ifosfamide Approved Phase 3 3778-73-2 3690
5
Vincristine Approved, Investigational Phase 3,Phase 1,Phase 2 2068-78-2, 57-22-7 5978
6
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
7
Lomustine Approved, Investigational Phase 3,Phase 2 13010-47-4 3950
8
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
9
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
10
Dacarbazine Approved, Investigational Phase 3,Phase 1,Phase 2,Early Phase 1 4342-03-4 5351166
11
Temozolomide Approved, Investigational Phase 3,Phase 2,Phase 1,Early Phase 1 85622-93-1 5394
12
Valproic Acid Approved, Investigational Phase 3,Phase 2 99-66-1 3121
13
chloroquine Approved, Investigational, Vet_approved Phase 3 54-05-7 2719
14
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
16
Isophosphamide mustard Phase 3 0
17 Alkylating Agents Phase 3,Phase 2,Phase 1,Early Phase 1
18 glucocorticoids Phase 3
19 Folic Acid Antagonists Phase 3
20 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
21 Hormone Antagonists Phase 3
22 Dermatologic Agents Phase 3
23 Nucleic Acid Synthesis Inhibitors Phase 3
24 Hormones Phase 3
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
26 Vitamin B Complex Phase 3
27 Etoposide phosphate Phase 3,Phase 1
28 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Early Phase 1
29 Anti-Inflammatory Agents Phase 3
30 Antirheumatic Agents Phase 3,Phase 1,Phase 2
31 Antimetabolites Phase 3,Phase 1,Early Phase 1
32 Antimetabolites, Antineoplastic Phase 3,Phase 1,Early Phase 1
33 Antimitotic Agents Phase 3,Phase 1,Phase 2
34 Calcium, Dietary Phase 3
35 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1,Early Phase 1
36 Antineoplastic Agents, Hormonal Phase 3
37 Antineoplastic Agents, Phytogenic Phase 3,Phase 1,Phase 2,Early Phase 1
38 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Early Phase 1
39 Central Nervous System Depressants Phase 3,Phase 2
40 GABA Agents Phase 3,Phase 2
41 Neurotransmitter Agents Phase 3,Phase 2
42 Tranquilizing Agents Phase 3,Phase 2
43 Anthelmintics Phase 3,Phase 1,Phase 2
44 Anticonvulsants Phase 3,Phase 2,Phase 1
45 Antiparasitic Agents Phase 3,Phase 1,Phase 2
46 Psychotropic Drugs Phase 3,Phase 2,Phase 1
47 Antimanic Agents Phase 3,Phase 2
48 Chloroquine diphosphate Phase 3 50-63-5
49 Analgesics Phase 3
50 Analgesics, Non-Narcotic Phase 3

Interventional clinical trials:

(show top 50) (show all 63)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed Gliomas Unknown status NCT00278278 Phase 3 cisplatin;etoposide;ifosfamide;lomustine;methotrexate;prednisone;vincristine sulfate
2 Prospective Trial of Two Hypofractionated Radiotherapy Regimens Versus Conventional Radiotherapy in Diffuse Brainstem Glioma in Children Unknown status NCT01878266 Phase 3
3 International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013) Not yet recruiting NCT03243461 Phase 3 Temozolomide + Valproic Acid;Temozolomide + Chloroquine
4 Palliative Re-irradiation for Progressive Diffuse Intrinsic Pontine Glioma (DIPG) in Children Completed NCT01777633 Phase 1, Phase 2
5 Phase 2 Study of Nimotuzumab in Pediatric Recurrent Diffuse Intrinsic Pontine Glioma Completed NCT00600054 Phase 2
6 Chemotherapy and Radiation Therapy After Surgery in Treating Children With Newly Diagnosed Astrocytoma, Glioblastoma Multiforme, Gliosarcoma, or Diffuse Intrinsic Pontine Glioma Completed NCT00028795 Phase 2 temozolomide
7 A Phase II Study of Pegylated Interferon Alfa 2b (PEG-Intron(Trademark)) in Children With Diffuse Pontine Gliomas Completed NCT00036569 Phase 2
8 Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors Completed NCT01836549 Phase 2 imetelstat sodium
9 Safety and Efficacy of Cabazitaxel in Pediatric Patients With Refractory Solid Tumors Including Central Nervous System Tumors Completed NCT01751308 Phase 1, Phase 2 Cabazitaxel (XRP6258)
10 MTX110 by Convection-Enhanced Delivery in Treating Participants With Newly-Diagnosed Diffuse Intrinsic Pontine Glioma Recruiting NCT03566199 Phase 1, Phase 2 Panobinostat Nanoparticle Formulation MTX110;Convection-Enhanced Delivery (CED)
11 Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication Recruiting NCT02233049 Phase 2 Erlotinib;Everolimus;Dasatinib
12 Prolonged Exposure to Doxorubicin in Patients With Glioblastoma Multiforme and Diffuse Intrinsic Pontine Glioma Recruiting NCT02758366 Phase 2 Doxorubicin
13 A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas Recruiting NCT01837862 Phase 1, Phase 2 Mebendazole;Vincristine;Carboplatin;Temozolomide;Bevacizumab;Irinotecan
14 An Investigational Immuno-therapy Study of Nivolumab Monotherapy and Nivolumab in Combination With Ipilimumab in Pediatric Patients With High Grade Primary CNS Malignancies Recruiting NCT03130959 Phase 2
15 Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 Recruiting NCT01884740 Phase 1, Phase 2 SIACI of Erbitux and Bevacizumab
16 Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade Gliomas Recruiting NCT02343406 Phase 2 Lomustine;ABT-414;Temozolomide
17 Molecularly Determined Treatment of Diffuse Intrinsic Pontine Gliomas (DIPG) Active, not recruiting NCT01182350 Phase 2 Bevacizumab;Erlotinib;Temozolomide
18 Vorinostat and Radiation Therapy Followed by Maintenance Therapy With Vorinostat in Treating Younger Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma Active, not recruiting NCT01189266 Phase 1, Phase 2 Vorinostat
19 Anti PD1 Antibody in Diffuse Intrinsic Pontine Glioma Active, not recruiting NCT01952769 Phase 1, Phase 2
20 A Study of DSP-7888 in Pediatric Patients With Relapsed or Refractory High Grade Gliomas Active, not recruiting NCT02750891 Phase 1, Phase 2 DSP-7888
21 Diffuse Intrinsic Pontine Glioma (DIPG) Reirradiation (ReRT) Active, not recruiting NCT01469247 Phase 1, Phase 2
22 Valproic Acid and Radiation Followed by Maintenance Valproic Acid and Bevacizumab in Children With High Grade Gliomas or Diffuse Intrinsic Pontine Glioma Active, not recruiting NCT00879437 Phase 2 Valproic acid;Bevacizumab
23 A Phase I/II Study of Ribociclib,a CDK4/6 Inhibitor, Following Radiation Therapy Active, not recruiting NCT02607124 Phase 1, Phase 2 Ribociclib
24 A Study of Atengenal and Astugenal in Diffuse, Intrinsic Pontine Glioma (DIPG) Active, not recruiting NCT02742883 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
25 Cilengitide and Metronomic Temozolomide for Relapsed or Refractory High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas in Children and Adolescents Terminated NCT01517776 Phase 2 Cilengitide;Temozolomide
26 Imiquimod/Brain Tumor Initiating Cell (BTIC) Vaccine in Brain Stem Glioma Completed NCT01400672 Phase 1 Imiquimod
27 PDGFR Inhibitor Crenolanib in Children/Young Adults With Diffuse Intrinsic Pontine Glioma or Recurrent High-Grade Glioma Completed NCT01393912 Phase 1 Crenolanib
28 Clinical Trial Evaluating the Combination of Vandetanib and Dasatinib During and After Radiation Therapy (RT) in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) Completed NCT00996723 Phase 1 vandetanib and dasatinib
29 Cilengitide in Combination With Irradiation in Children With Diffuse Intrinsic Pontine Glioma Completed NCT01165333 Phase 1 Cilengitide dose escalation;Cilengitide
30 ZD6474 to Treat Advanced Brain Cancer in Patients Completed NCT00272350 Phase 1 Steroids;ZD6474
31 A Phase I Study of SB939 in Pediatric Patients With Refractory Solid Tumours and Leukemia Completed NCT01184274 Phase 1 SB939
32 Study of Suberoylanilide Hydroxamic Acid (SAHA) With Temsirolimus in Children With Diffuse Intrinsic Pontine Glioma (DIPG) Recruiting NCT02420613 Phase 1 Vorinostat;Temsirolimus
33 Trial of Panobinostat in Children With Diffuse Intrinsic Pontine Glioma Recruiting NCT02717455 Phase 1 LBH589
34 WEE1 Inhibitor AZD1775 and Local Radiation Therapy in Treating Children With Newly Diagnosed Diffuse Intrinsic Pontine Gliomas Recruiting NCT01922076 Phase 1 Adavosertib
35 CED With Irinotecan Liposome Injection Using Real Time Imaging in Children With DIPG Recruiting NCT03086616 Phase 1 Convection Enhanced Delivery (CED) of Nanoliposomal irinotecan (nal-IRI)
36 ONC201 in Pediatric H3 K27M Gliomas Recruiting NCT03416530 Phase 1 ONC201
37 Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma Recruiting NCT02359565 Phase 1
38 Oncolytic Adenovirus, DNX-2401, for Naive Diffuse Intrinsic Pontine Gliomas Recruiting NCT03178032 Phase 1
39 Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors Recruiting NCT02644460 Phase 1 Abemaciclib
40 H3.3K27M Peptide Vaccine for Children With Newly Diagnosed DIPG and Other Gliomas Recruiting NCT02960230 Phase 1
41 Phase I Study of APX005M in Pediatric CNS Tumors Recruiting NCT03389802 Phase 1
42 Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I) Recruiting NCT03396575 Phase 1 Cyclophosphamide + Fludarabine Lymphodepletive Conditioning;Dose-Intensified TMZ;Td vaccine
43 A Study of Ad-RTS-hIL-12 + Veledimex in Pediatric Subjects With Brain Tumors or DIPG Recruiting NCT03330197 Phase 1 oral veledimex
44 Convection-Enhanced Delivery of 124I-8H9 for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy Recruiting NCT01502917 Phase 1
45 Study of the IDO Pathway Inhibitor, Indoximod, and Temozolomide for Pediatric Patients With Progressive Primary Malignant Brain Tumors Recruiting NCT02502708 Phase 1 Indoximod;Temozolomide;Cyclophosphamide;Etoposide
46 Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors Recruiting NCT03387020 Phase 1 Everolimus;Ribociclib
47 Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors Recruiting NCT02644291 Phase 1 Mebendazole
48 A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG) Recruiting NCT03355794 Phase 1 ribociclib;Everolimus
49 Wild-Type Reovirus in Combination With Sargramostim in Treating Younger Patients With High-Grade Relapsed or Refractory Brain Tumors Recruiting NCT02444546 Phase 1
50 Lenalidomide and Radiation Therapy in High Grade Gliomas or Diffuse Intrinsic Pontine Gliomas Active, not recruiting NCT01222754 Phase 1 Lenalidomide

Search NIH Clinical Center for Diffuse Intrinsic Pontine Glioma

Genetic Tests for Diffuse Intrinsic Pontine Glioma

Anatomical Context for Diffuse Intrinsic Pontine Glioma

MalaCards organs/tissues related to Diffuse Intrinsic Pontine Glioma:

41
Brain, Pons, Spinal Cord, Eye, Endothelial

Publications for Diffuse Intrinsic Pontine Glioma

Articles related to Diffuse Intrinsic Pontine Glioma:

(show top 50) (show all 89)
# Title Authors Year
1
Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries. ( 29746225 )
2018
2
CDK4/6 and PDGFRA Signaling as Therapeutic Targets in Diffuse Intrinsic Pontine Glioma. ( 29904623 )
2018
3
Corrigendum: Immune Response Generated With the Administration of Autologous Dendritic Cells Pulsed With an Allogenic Tumoral Cell-Lines Lysate in Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma. ( 29897054 )
2018
4
Correction to: A phase I/II study of gemcitabine during radiotherapy in children with newly diagnosed diffuse intrinsic pontine glioma. ( 29063425 )
2018
5
IL-13 receptors as possible therapeutic targets in diffuse intrinsic pontine glioma. ( 29621254 )
2018
6
The Integration of Biology Into the Treatment of Diffuse Intrinsic Pontine Glioma: A Review of the North American Clinical Trial Perspective. ( 29868485 )
2018
7
Convection-enhanced delivery for diffuse intrinsic pontine glioma: a single-centre, dose-escalation, phase 1 trial. ( 29914796 )
2018
8
T2-weighted images are superior to other MR image types for the determination of diffuse intrinsic pontine glioma intratumoral heterogeneity. ( 29151166 )
2018
9
Preclinical analysis of MTOR complex 1/2 inhibition in diffuse intrinsic pontine glioma. ( 29207163 )
2018
10
Dual targeting of mitochondrial function and mTOR pathway as a therapeutic strategy for diffuse intrinsic pontine glioma. ( 29484131 )
2018
11
Computation of reliable textural indices from multimodal brain MRI: suggestions based on a study of patients with diffuse intrinsic pontine glioma. ( 29633962 )
2018
12
Importance of immune monitoring approaches and the use of immune checkpoints for the treatment of diffuse intrinsic pontine glioma: From bench to clinic and vice versa (Review). ( 29484440 )
2018
13
Convection-enhanced delivery: chemosurgery in diffuse intrinsic pontine glioma. ( 29914797 )
2018
14
Phase 1 trial, pharmacokinetics, and pharmacodynamics of dasatinib combined with crizotinib in children with recurrent or progressive high-grade and diffuse intrinsic pontine glioma. ( 29512900 )
2018
15
Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells. ( 29967352 )
2018
16
Prospective Feasibility and Safety Assessment of Surgical Biopsy for Patients with Newly Diagnosed Diffuse Intrinsic Pontine Glioma. ( 29741745 )
2018
17
Non-inflammatory tumor microenvironment of diffuse intrinsic pontine glioma. ( 29954445 )
2018
18
Characterization of Diffuse Intrinsic Pontine Glioma Radiosensitivity using Synchrotron Microbeam Radiotherapy and Conventional Radiation Therapy In Vitro. ( 29364085 )
2018
19
Preliminary results of immune modulating antibody MDV9300 (pidilizumab) treatment in children with diffuse intrinsic pontine glioma. ( 29143272 )
2018
20
Immune Response Generated With the Administration of Autologous Dendritic Cells Pulsed With an Allogenic Tumoral Cell-Lines Lysate in Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma. ( 29755954 )
2018
21
REST upregulates gremlin to modulate diffuse intrinsic pontine glioma vasculature. ( 29435175 )
2018
22
End-of-life care of children with diffuse intrinsic pontine glioma. ( 29397521 )
2018
23
Diffuse Intrinsic Pontine Glioma : Clinical Features, Molecular Genetics, and Novel Targeted Therapeutics. ( 29742880 )
2018
24
Effective Drug Delivery in Diffuse Intrinsic Pontine Glioma: A Theoretical Model to Identify Potential Candidates. ( 29164054 )
2017
25
Repurposing the anti-epileptic drug sodium valproate as an adjuvant treatment for diffuse intrinsic pontine glioma. ( 28542253 )
2017
26
Measurable Supratentorial White Matter Volume Changes in Patients with Diffuse Intrinsic Pontine Glioma Treated with an Anti-Vascular Endothelial Growth Factor Agent, Steroids, and Radiation. ( 28428205 )
2017
27
Deceptive morphologic and epigenetic heterogeneity in diffuse intrinsic pontine glioma. ( 28947983 )
2017
28
Multiregional tumor drug-uptake imaging by PET and microvascular morphology in end-stage diffuse intrinsic pontine glioma. ( 28818988 )
2017
29
MRI and PET: Noninvasive Tools to Probe the Biology of Diffuse Intrinsic Pontine Glioma. ( 28385794 )
2017
30
Untangling the role of mutant histone H3 in diffuse intrinsic pontine glioma. ( 28388610 )
2017
31
Treatment-Related Noncontiguous Radiologic Changes in Children With Diffuse Intrinsic Pontine Glioma Treated With Expanded Irradiation Fields and Antiangiogenic Therapy. ( 29165288 )
2017
32
Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. ( 28966033 )
2017
33
Preliminary dosimetric study on feasibility of multi-beam boron neutron capture therapy in patients with diffuse intrinsic pontine glioma without craniotomy. ( 28662135 )
2017
34
Combination of EZH2 inhibitor and BET inhibitor for treatment of diffuse intrinsic pontine glioma. ( 29118968 )
2017
35
External validation of the diffuse intrinsic pontine glioma survival prediction model: a collaborative report from the International DIPG Registry and the SIOPE DIPG Registry. ( 28560664 )
2017
36
Characterization of Diffuse Intrinsic Pontine Glioma Radiosensitivity using Synchrotron Microbeam Radiotherapy and Conventional Radiation Therapy In Vitro. ( 29189105 )
2017
37
Culture methods of diffuse intrinsic pontine glioma cells determine response to targeted therapies. ( 28947132 )
2017
38
Multi-focal sequencing of a diffuse intrinsic pontine glioma establishes PTEN loss as an early event. ( 29872713 )
2017
39
Epigenetic Targeted Therapy for Diffuse Intrinsic Pontine Glioma. ( 28592748 )
2017
40
Targeting CDK7 or BRD4 Blocks Diffuse Intrinsic Pontine Glioma Growth. ( 28455397 )
2017
41
Palliative Care Options for a Young Adult Patient with a Diffuse Intrinsic Pontine Glioma. ( 29057192 )
2017
42
Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma. ( 28790919 )
2017
43
Rapid and fulminant leptomeningeal spread following radiotherapy in diffuse intrinsic pontine glioma. ( 28084680 )
2017
44
BMI-1 is a potential therapeutic target in diffuse intrinsic pontine glioma. ( 28968963 )
2017
45
Transcriptional Dependencies in Diffuse Intrinsic Pontine Glioma. ( 28434841 )
2017
46
Neonatal Respiratory Failure Caused by Congenital Diffuse Intrinsic Pontine Glioma. ( 28116951 )
2017
47
Genomic Insights into Diffuse Intrinsic Pontine Glioma. ( 28401062 )
2017
48
Positron emission tomography imaging in diffuse intrinsic pontine glioma. ( 28856152 )
2017
49
Contemporary survival endpoints: an International Diffuse Intrinsic Pontine Glioma Registry study. ( 28821206 )
2017
50
Pre-Clinical Study of Panobinostat in Xenograft and Genetically Engineered Murine Diffuse Intrinsic Pontine Glioma Models. ( 28052119 )
2017

Variations for Diffuse Intrinsic Pontine Glioma

Expression for Diffuse Intrinsic Pontine Glioma

Search GEO for disease gene expression data for Diffuse Intrinsic Pontine Glioma.

Pathways for Diffuse Intrinsic Pontine Glioma

Pathways related to Diffuse Intrinsic Pontine Glioma according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.2 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
2
Show member pathways
14.01 HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F
3
Show member pathways
13.91 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
4
Show member pathways
13.91 ACVR1 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C
5
Show member pathways
13.86 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
6
Show member pathways
13.85 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
7
Show member pathways
13.84 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
8
Show member pathways
13.63 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
9
Show member pathways
13.61 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
10
Show member pathways
13.58 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
11
Show member pathways
13.52 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
12
Show member pathways
13.43 HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F
13
Show member pathways
13.43 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
14
Show member pathways
13.27 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
15
Show member pathways
13.16 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
16
Show member pathways
13.15 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
17
Show member pathways
13.12 HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F
18
Show member pathways
13.03 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
19
Show member pathways
12.89 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
20
Show member pathways
12.53 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
21
Show member pathways
12.5 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
22 12.3 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
23
Show member pathways
12.27 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
24
Show member pathways
12.09 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
25 12 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
26 11.66 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
27 10.77 HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F

GO Terms for Diffuse Intrinsic Pontine Glioma

Cellular components related to Diffuse Intrinsic Pontine Glioma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 nuclear chromosome GO:0000228 9.93 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
2 nucleosome GO:0000786 9.73 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
3 nuclear chromosome, telomeric region GO:0000784 9.69 H3F3A H3F3B PARP1
4 Barr body GO:0001740 9.48 H3F3A H3F3B
5 nuclear nucleosome GO:0000788 9.4 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
6 nucleus GO:0005634 10.36 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
7 membrane GO:0016020 10.34 ACVR1 HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E
8 extracellular region GO:0005576 10.25 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
9 extracellular exosome GO:0070062 10.25 DDAH1 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C
10 nucleoplasm GO:0005654 10.24 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
11 protein-containing complex GO:0032991 10.2 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
12 chromosome GO:0005694 10.07 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D

Biological processes related to Diffuse Intrinsic Pontine Glioma according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 protein heterotetramerization GO:0051290 9.96 HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F
2 interleukin-7-mediated signaling pathway GO:0038111 9.85 HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F
3 multicellular organism growth GO:0035264 9.77 H3F3A H3F3B MTOR
4 regulation of gene silencing GO:0060968 9.65 HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F
5 nucleus organization GO:0006997 9.62 H3F3A H3F3B
6 DNA replication-independent nucleosome assembly GO:0006336 9.61 H3F3A H3F3B
7 positive regulation of protein localization to nucleus GO:1900182 9.61 PARP1 PLK1
8 muscle cell differentiation GO:0042692 9.6 H3F3A H3F3B
9 pericentric heterochromatin assembly GO:0031508 9.58 H3F3A H3F3B
10 regulation of centromere complex assembly GO:0090230 9.58 H3F3A H3F3B
11 telomeric heterochromatin assembly GO:0031509 9.57 H3F3A H3F3B
12 negative regulation of chromosome condensation GO:1902340 9.56 H3F3A H3F3B
13 DNA replication-dependent nucleosome assembly GO:0006335 9.32 HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F
14 positive regulation of gene expression, epigenetic GO:0045815 10.31 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
15 cellular protein metabolic process GO:0044267 10.3 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
16 regulation of hematopoietic stem cell differentiation GO:1902036 10.29 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
17 regulation of gene silencing by miRNA GO:0060964 10.27 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
18 blood coagulation GO:0007596 10.26 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
19 chromatin organization GO:0006325 10.25 HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F
20 regulation of megakaryocyte differentiation GO:0045652 10.23 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
21 negative regulation of gene expression, epigenetic GO:0045814 10.21 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
22 nucleosome assembly GO:0006334 10.18 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
23 chromatin silencing at rDNA GO:0000183 10.15 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
24 telomere organization GO:0032200 10.1 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D

Molecular functions related to Diffuse Intrinsic Pontine Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cadherin binding GO:0045296 9.85 HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F
2 protein heterodimerization activity GO:0046982 9.73 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
3 nucleosomal DNA binding GO:0031492 9.4 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D
4 protein binding GO:0005515 10.25 ACVR1 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C
5 DNA binding GO:0003677 10.07 H3F3A H3F3B HIST1H3A HIST1H3B HIST1H3C HIST1H3D

Sources for Diffuse Intrinsic Pontine Glioma

3 CDC
7 CNVD
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10 dbSNP
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