MCID: DFF029
MIFTS: 31

Diffuse Large B-Cell Lymphoma of the Central Nervous System

Categories: Blood diseases, Rare diseases, Neuronal diseases, Immune diseases

Aliases & Classifications for Diffuse Large B-Cell Lymphoma of the Central Nervous System

MalaCards integrated aliases for Diffuse Large B-Cell Lymphoma of the Central Nervous System:

Name: Diffuse Large B-Cell Lymphoma of the Central Nervous System 59
Dlbcl of the Cns 59

Characteristics:

Orphanet epidemiological data:

59
diffuse large b-cell lymphoma of the central nervous system
Inheritance: Multigenic/multifactorial,Not applicable;

Classifications:



External Ids:

Orphanet 59 ORPHA300849
ICD10 via Orphanet 34 C83.3

Summaries for Diffuse Large B-Cell Lymphoma of the Central Nervous System

MalaCards based summary : Diffuse Large B-Cell Lymphoma of the Central Nervous System, also known as dlbcl of the cns, is related to b-cell lymphomas and lymphoma. An important gene associated with Diffuse Large B-Cell Lymphoma of the Central Nervous System is MYC (MYC Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are Pathways in cancer and Apoptosis Modulation and Signaling. The drugs nivolumab and Immunoglobulin G have been mentioned in the context of this disorder. Affiliated tissues include b cells and t cells, and related phenotype is pigmentation.

Related Diseases for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Diseases related to Diffuse Large B-Cell Lymphoma of the Central Nervous System via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 b-cell lymphomas 30.2 BCL2 MYC
2 lymphoma 30.0 BCL2 MYC
3 diffuse large b-cell lymphoma 10.6
4 peripheral t-cell lymphoma 10.1
5 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 9.7 BCL2 MYC
6 suppressor of tumorigenicity 3 9.7 BCL2 MYC
7 follicular lymphoma 9.6 BCL2 MYC
8 mantle cell lymphoma 9.6 BCL2 MYC
9 adamantinoma of long bones 9.6 BCL2 MYC
10 burkitt lymphoma 9.6 BCL2 MYC
11 lymphoma, non-hodgkin, familial 9.5 BCL2 MYC
12 gastric adenocarcinoma 9.5 BCL2 MYC
13 acute promyelocytic leukemia 9.3 BCL2 MYC
14 nasopharyngeal carcinoma 9.2 BCL2 MYC
15 endometrial cancer 9.0 BCL2 MYC

Graphical network of the top 20 diseases related to Diffuse Large B-Cell Lymphoma of the Central Nervous System:



Diseases related to Diffuse Large B-Cell Lymphoma of the Central Nervous System

Symptoms & Phenotypes for Diffuse Large B-Cell Lymphoma of the Central Nervous System

MGI Mouse Phenotypes related to Diffuse Large B-Cell Lymphoma of the Central Nervous System:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.62 BCL2 MYC

Drugs & Therapeutics for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Drugs for Diffuse Large B-Cell Lymphoma of the Central Nervous System (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Immunoglobulin G Phase 2
3 Antibodies Phase 2
4 Immunoglobulins Phase 2
5 Antibodies, Monoclonal Phase 2
6
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
7 Pomalidomide Approved Phase 1 19171-19-8
8 Dexamethasone acetate Phase 1 1177-87-3
9 glucocorticoids Phase 1
10
protease inhibitors Phase 1
11 Gastrointestinal Agents Phase 1
12 HIV Protease Inhibitors Phase 1
13 Hormone Antagonists Phase 1
14 Angiogenesis Inhibitors Phase 1
15 Hormones Phase 1
16 Angiogenesis Modulating Agents Phase 1
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
18 Peripheral Nervous System Agents Phase 1
19 Anti-Bacterial Agents Phase 1
20 Immunosuppressive Agents Phase 1
21 Anti-Infective Agents Phase 1
22 Antiemetics Phase 1
23 Anti-Inflammatory Agents Phase 1
24 BB 1101 Phase 1
25 Autonomic Agents Phase 1
26 Antineoplastic Agents, Hormonal Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Nivolumab With or Without Varlilumab in Treating Patients With Relapsed or Refractory Aggressive B-cell Lymphomas Recruiting NCT03038672 Phase 2 Varlilumab
2 Pomalidomide and Dexamethasone in Treating Patients With Relapsed or Refractory Primary Central Nervous System Lymphoma or Newly Diagnosed or Relapsed or Refractory Intraocular Lymphoma Suspended NCT01722305 Phase 1 Dexamethasone;Pomalidomide

Search NIH Clinical Center for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Genetic Tests for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Anatomical Context for Diffuse Large B-Cell Lymphoma of the Central Nervous System

MalaCards organs/tissues related to Diffuse Large B-Cell Lymphoma of the Central Nervous System:

41
B Cells, T Cells

Publications for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Articles related to Diffuse Large B-Cell Lymphoma of the Central Nervous System:

# Title Authors Year
1
Development of Epstein-Barr Virus-related Primary Diffuse Large B-cell Lymphoma of the Central Nervous System in a Patient with Peripheral T-cell Lymphoma, Not Otherwise Specified after Mogamulizumab Treatment. ( 28924126 )
2017
2
MYC and BCL2 overexpression is associated with a higher class of Memorial Sloan-Kettering Cancer Center prognostic model and poor clinical outcome in primary diffuse large B-cell lymphoma of the central nervous system. ( 27286976 )
2016
3
MYC protein expression is associated with poor prognosis in primary diffuse large B-cell lymphoma of the central nervous system. ( 26010683 )
2015
4
MYC protein expression in primary diffuse large B-cell lymphoma of the central nervous system. ( 25479599 )
2014
5
Differential expression of Toll-like receptor (TLR) and B cell receptor (BCR) signaling molecules in primary diffuse large B-cell lymphoma of the central nervous system. ( 25391967 )
2014
6
Diagnosis of leptomeningeal disease in diffuse large B-cell lymphomas of the central nervous system by flow cytometry and cytopathology. ( 20727005 )
2010
7
Immunohistochemical analysis of cleaved caspase-3 detects high level of apoptosis frequently in diffuse large B-cell lymphomas of the central nervous system. ( 15743320 )
2005
8
Primary diffuse large B-cell lymphomas of the central nervous system are targeted by aberrant somatic hypermutation. ( 14592832 )
2004
9
Molecular characterization of BCL6 breakpoints in primary diffuse large B-cell lymphomas of the central nervous system identifies GAPD as novel translocation partner. ( 14655758 )
2003
10
Interphase cytogenetic analysis of lymphoma-associated chromosomal breakpoints in primary diffuse large B-cell lymphomas of the central nervous system. ( 12387458 )
2002

Variations for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Cosmic variations for Diffuse Large B-Cell Lymphoma of the Central Nervous System:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM43450 TNFAIP3 haematopoietic and lymphoid tissue,central nervous system,lymphoid neoplasm,diffuse large B cell lymphoma c.703C>A p.P235T 6:137876064-137876064 4
2 COSM85940 MYD88 haematopoietic and lymphoid tissue,central nervous system,lymphoid neoplasm,diffuse large B cell lymphoma c.794T>C p.L265P 3:38141150-38141150 4
3 COSM1737939 CD79B haematopoietic and lymphoid tissue,central nervous system,lymphoid neoplasm,diffuse large B cell lymphoma c.586T>G p.Y196D 17:63929439-63929439 4
4 COSM220734 CD79B haematopoietic and lymphoid tissue,central nervous system,lymphoid neoplasm,diffuse large B cell lymphoma c.586T>C p.Y196H 17:63929439-63929439 4
5 COSM220736 CD79B haematopoietic and lymphoid tissue,central nervous system,lymphoid neoplasm,diffuse large B cell lymphoma c.587A>G p.Y196C 17:63929438-63929438 4
6 COSM5045028 CD79B haematopoietic and lymphoid tissue,central nervous system,lymphoid neoplasm,diffuse large B cell lymphoma c.591G>C p.E197D 17:63929434-63929434 4
7 COSM43456 CARD11 haematopoietic and lymphoid tissue,central nervous system,lymphoid neoplasm,diffuse large B cell lymphoma c.711T>G p.N237K 7:2939902-2939902 4
8 COSM476 BRAF haematopoietic and lymphoid tissue,central nervous system,lymphoid neoplasm,B cell lymphoma unspecified c.1799T>A p.V600E 7:140753336-140753336 2

Expression for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Search GEO for disease gene expression data for Diffuse Large B-Cell Lymphoma of the Central Nervous System.

Pathways for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Pathways related to Diffuse Large B-Cell Lymphoma of the Central Nervous System according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1 12.38 BCL2 MYC
2
Show member pathways
12.35 BCL2 MYC
3
Show member pathways
12.34 BCL2 MYC
4
Show member pathways
12.31 BCL2 MYC
5
Show member pathways
12.25 BCL2 MYC
6
Show member pathways
12.21 BCL2 MYC
7
Show member pathways
12.17 BCL2 MYC
8
Show member pathways
12.16 BCL2 MYC
9
Show member pathways
12.14 BCL2 MYC
10 12.08 BCL2 MYC
11
Show member pathways
12.05 BCL2 MYC
12
Show member pathways
11.96 BCL2 MYC
13 11.88 BCL2 MYC
14 11.83 BCL2 MYC
15
Show member pathways
11.77 BCL2 MYC
16 11.75 BCL2 MYC
17 11.74 BCL2 MYC
18
Show member pathways
11.67 BCL2 MYC
19
Show member pathways
11.65 BCL2 MYC
20 11.58 BCL2 MYC
21 11.57 BCL2 MYC
22
Show member pathways
11.48 BCL2 MYC
23 11.45 BCL2 MYC
24 11.35 BCL2 MYC
25
Show member pathways
11.26 BCL2 MYC
26 11.19 BCL2 MYC
27 11.03 BCL2 MYC
28
Show member pathways
10.97 BCL2 MYC
29 10.9 BCL2 MYC
30 10.6 BCL2 MYC
32
Show member pathways
9.97 BCL2 MYC

GO Terms for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Biological processes related to Diffuse Large B-Cell Lymphoma of the Central Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.48 BCL2 MYC
2 cell proliferation GO:0008283 9.46 BCL2 MYC
3 cytokine-mediated signaling pathway GO:0019221 9.43 BCL2 MYC
4 response to drug GO:0042493 9.4 BCL2 MYC
5 regulation of gene expression GO:0010468 9.37 BCL2 MYC
6 cellular response to hypoxia GO:0071456 9.32 BCL2 MYC
7 branching involved in ureteric bud morphogenesis GO:0001658 9.26 BCL2 MYC
8 ovarian follicle development GO:0001541 9.16 BCL2 MYC
9 response to gamma radiation GO:0010332 8.96 BCL2 MYC
10 positive regulation of smooth muscle cell migration GO:0014911 8.62 BCL2 MYC

Molecular functions related to Diffuse Large B-Cell Lymphoma of the Central Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 8.96 BCL2 MYC
2 transcription factor binding GO:0008134 8.62 BCL2 MYC

Sources for Diffuse Large B-Cell Lymphoma of the Central Nervous System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....