MCID: DFF029
MIFTS: 30

Diffuse Large B-Cell Lymphoma of the Central Nervous System

Categories: Blood diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Diffuse Large B-Cell Lymphoma of the Central Nervous System

MalaCards integrated aliases for Diffuse Large B-Cell Lymphoma of the Central Nervous System:

Name: Diffuse Large B-Cell Lymphoma of the Central Nervous System 58
Dlbcl of the Cns 58

Characteristics:

Orphanet epidemiological data:

58
diffuse large b-cell lymphoma of the central nervous system
Inheritance: Multigenic/multifactorial,Not applicable;

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

ICD10 via Orphanet 33 C83.3
Orphanet 58 ORPHA300849

Summaries for Diffuse Large B-Cell Lymphoma of the Central Nervous System

MalaCards based summary : Diffuse Large B-Cell Lymphoma of the Central Nervous System, also known as dlbcl of the cns, is related to b-cell lymphoma and follicular lymphoma. An important gene associated with Diffuse Large B-Cell Lymphoma of the Central Nervous System is MYC (MYC Proto-Oncogene, BHLH Transcription Factor), and among its related pathways/superpathways are Gastric cancer and Apoptosis Modulation and Signaling. The drugs Hydrocortisone and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and brain.

Related Diseases for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Diseases related to Diffuse Large B-Cell Lymphoma of the Central Nervous System via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 b-cell lymphoma 30.9 MYC BCL2
2 follicular lymphoma 29.8 MYC BCL2
3 primary central nervous system lymphoma 12.0
4 diffuse large b-cell lymphoma 10.9
5 lymphoma 10.7
6 central nervous system lymphoma 10.5
7 systemic lupus erythematosus 10.2
8 aspergillosis 10.2
9 peripheral t-cell lymphoma 10.2
10 lymphoproliferative syndrome 10.2
11 uveitis 10.2
12 lupus erythematosus 10.2
13 47,xyy 10.2
14 post-transplant lymphoproliferative disease 10.2
15 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 9.7 MYC BCL2
16 suppressor of tumorigenicity 3 9.7 MYC BCL2
17 alk-negative anaplastic large cell lymphoma 9.7 MYC BCL2
18 reticulosarcoma 9.7 MYC BCL2
19 inflammatory myofibroblastic tumor 9.7 MYC BCL2
20 lymphoma, mucosa-associated lymphoid type 9.7 MYC BCL2
21 ovarian serous cystadenocarcinoma 9.7 MYC BCL2
22 adenocarcinoma 9.7 MYC BCL2
23 li-fraumeni syndrome 9.7 MYC BCL2
24 uterine carcinosarcoma 9.7 MYC BCL2
25 mantle cell lymphoma 9.6 MYC BCL2
26 breast adenocarcinoma 9.6 MYC BCL2
27 t-cell lymphoblastic leukemia/lymphoma 9.6 MYC BCL2
28 wilms tumor 1 9.6 MYC BCL2
29 colon adenocarcinoma 9.6 MYC BCL2
30 burkitt lymphoma 9.5 MYC BCL2
31 leukemia, chronic myeloid 9.5 MYC BCL2
32 myeloma, multiple 9.5 MYC BCL2
33 nasopharyngeal carcinoma 9.4 MYC BCL2
34 lymphoma, non-hodgkin, familial 9.2 MYC BCL2

Graphical network of the top 20 diseases related to Diffuse Large B-Cell Lymphoma of the Central Nervous System:



Diseases related to Diffuse Large B-Cell Lymphoma of the Central Nervous System

Symptoms & Phenotypes for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Drugs & Therapeutics for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Drugs for Diffuse Large B-Cell Lymphoma of the Central Nervous System (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydrocortisone Approved, Vet_approved Phase 1, Phase 2 50-23-7 5754
2
Hydrocortisone acetate Approved, Vet_approved Phase 1, Phase 2 50-03-3
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1, Phase 2 1177-87-3
4
Dexamethasone Approved, Investigational, Vet_approved Phase 1, Phase 2 50-02-2 5743
5 Hormones Phase 1, Phase 2
6 Antineoplastic Agents, Hormonal Phase 1, Phase 2
7 Proton Pump Inhibitors Phase 1, Phase 2
8 Hormone Antagonists Phase 1, Phase 2
9
protease inhibitors Phase 1, Phase 2
10 Hydrocortisone 17-butyrate 21-propionate Phase 1, Phase 2
11 Antiemetics Phase 1, Phase 2
12 Histamine H2 Antagonists Phase 1, Phase 2
13 HIV Protease Inhibitors Phase 1, Phase 2
14 Hydrocortisone hemisuccinate Phase 1, Phase 2
15 glucocorticoids Phase 1, Phase 2
16 Dexamethasone 21-phosphate Phase 1, Phase 2
17 Gastrointestinal Agents Phase 1, Phase 2
18 BB 1101 Phase 1, Phase 2
19 Anti-Inflammatory Agents Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open-Label, Phase 1/2 Study Evaluating AVM0703 in Patients With Lymphoid Malignancies (WWRD Study) Not yet recruiting NCT04329728 Phase 1, Phase 2 Supra-Pharmacologic Dexamethasone sodium phosphate;Hydrocortisone;Proton pump inhibitor

Search NIH Clinical Center for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Genetic Tests for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Anatomical Context for Diffuse Large B-Cell Lymphoma of the Central Nervous System

MalaCards organs/tissues related to Diffuse Large B-Cell Lymphoma of the Central Nervous System:

40
B Cells, T Cells, Brain, Testis, Pineal

Publications for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Articles related to Diffuse Large B-Cell Lymphoma of the Central Nervous System:

(show all 40)
# Title Authors PMID Year
1
Redox reaction and clinical outcome of primary diffuse large B-cell lymphoma of the central nervous system: Prognostic role of metabolic and textural parameters of 62Cu-diacetyl-bis (N4-methylthiosemicarbazone) PET/computed tomography in a small patient cohort. 61
32371672 2020
2
Induction therapy with the MATRix regimen in patients with newly diagnosed primary diffuse large B-cell lymphoma of the central nervous system - an international study of feasibility and efficacy in routine clinical practice. 61
31997308 2020
3
Primary Central Nervous System Lymphoma in a Patient on Adalimumab Therapy for Chronic Plaque Psoriasis. 61
32247793 2020
4
Diffuse large B-cell lymphoma variants: an update. 61
31735345 2020
5
Tumor and Cerebrospinal Fluid microRNAs in Primary Central Nervous System Lymphomas. 61
31731456 2019
6
Clinicopathological analysis of sinonasal malignant lymphoma in an HTLV-1 endemic area in Japan -special focus on primary sinonasal diffuse large B-cell lymphoma. 61
31391402 2019
7
Branched clonal evolution: nodal follicular lymphoma and primary diffuse large B-cell lymphoma of the central nervous system. 61
30890596 2019
8
Delayed Contrast Enhancement in Magnetic Resonance Imaging and Vascular Morphology of Primary Diffuse Large B-Cell Lymphoma (DLBCL) of the Central Nervous System (CNS): A Retrospective Study. 61
31055591 2019
9
Secondary diffuse large B cell lymphoma of the central nervous system: retrospective review of case series. 61
30182348 2019
10
Aggressive B cell lymphomas in the 2017 revised WHO classification of tumors of hematopoietic and lymphoid tissues. 61
30380402 2019
11
Diffuse large B-cell lymphoma of the central nervous system presenting as "lymphomatosis cerebri" and dementia in elderly man: Case report and review of the literature. 61
30732171 2019
12
High tumoral PD-L1 expression and low PD-1+ or CD8+ tumor-infiltrating lymphocytes are predictive of a poor prognosis in primary diffuse large B-cell lymphoma of the central nervous system. 61
31428525 2019
13
A Rare Case of Spontaneous Remission and Relapse of a Primary Central Nervous System Lymphoma. 61
30684376 2018
14
Response-adapted radiation therapy for newly diagnosed primary diffuse large B-cell lymphoma of the CNS treated with methotrexate-based systemic therapy. 61
30370365 2018
15
Clonal Evolution in Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System. 61
29629945 2018
16
An Autopsy Case of Epstein-Barr Virus-Associated Diffuse Large B-Cell Lymphoma of the Central Nervous System in an Immunocompromised Host. 61
28774170 2018
17
Prognostic implications of tumor-infiltrating macrophages, M2 macrophages, regulatory T-cells, and indoleamine 2,3-dioxygenase-positive cells in primary diffuse large B-cell lymphoma of the central nervous system. 61
29900049 2018
18
[Clinical Analysis of Combination Chemotherapy Using High Dose Methotrexate, Rituximab, and Vincristine with or without Procarbazine for Elderly Patients with Diffuse Large B-Cell Lymphoma of the Central Nervous System]. 61
29361628 2017
19
Development of Epstein-Barr Virus-related Primary Diffuse Large B-cell Lymphoma of the Central Nervous System in a Patient with Peripheral T-cell Lymphoma, Not Otherwise Specified after Mogamulizumab Treatment. 61
28924126 2017
20
B-cell posttransplant lymphoproliferative disorder isolated to the central nervous system is Epstein-Barr virus positive and lacks p53 and Myc expression by immunohistochemistry. 61
27993575 2017
21
EBV-positive post-transplant lymphoproliferative disorder presenting as primary diffuse large B-cell lymphoma of the central nervous system. 61
28984115 2017
22
Mutations or copy number losses of CD58 and TP53 genes in diffuse large B cell lymphoma are independent unfavorable prognostic factors. 61
27825110 2016
23
Clinicopathological features of primary diffuse large B-cell lymphoma of the central nervous system - strong EZH2 expression implying diagnostic and therapeutic implication. 61
27807891 2016
24
MYC and BCL2 overexpression is associated with a higher class of Memorial Sloan-Kettering Cancer Center prognostic model and poor clinical outcome in primary diffuse large B-cell lymphoma of the central nervous system. 61
27286976 2016
25
Primary diffuse large B-cell lymphoma of the central nervous system: A case report and literature review. 61
27123068 2016
26
STAT3 activation is associated with cerebrospinal fluid interleukin-10 (IL-10) in primary central nervous system diffuse large B cell lymphoma. 61
26080800 2015
27
Primary diffuse large B-cell lymphoma of the central nervous system in pineal gland: Report of a rare case with review of literature. 61
26275286 2015
28
MYC protein expression is associated with poor prognosis in primary diffuse large B-cell lymphoma of the central nervous system. 61
26010683 2015
29
Secondary diffuse large B-cell lymphoma of the central nervous system: the need for better predictors. 61
26099732 2015
30
Primary central nervous system lymphoma mimicking recurrent depressive disorder: A case report. 61
25789049 2015
31
Diagnostic value of interleukin-10 in cerebrospinal fluid for diffuse large B-cell lymphoma of the central nervous system. 61
25258254 2015
32
Differential expression of Toll-like receptor (TLR) and B cell receptor (BCR) signaling molecules in primary diffuse large B-cell lymphoma of the central nervous system. 61
25391967 2015
33
MYC protein expression in primary diffuse large B-cell lymphoma of the central nervous system. 61
25479599 2014
34
Current strategies in the diagnosis of diffuse large B-cell lymphoma of the central nervous system. 61
22077417 2012
35
[Analysis of the immunohistochemical subtypes and prognosis of primary diffuse large B cell lymphoma of the central nervous system]. 61
22780928 2012
36
Identification of microRNAs in the cerebrospinal fluid as marker for primary diffuse large B-cell lymphoma of the central nervous system. 61
21200023 2011
37
Diffuse large B-cell lymphoma involving the central nervous system. 61
21087986 2011
38
Diffuse large B-cell lymphoma of the central nervous system in mycophenolate mofetil-treated patients with systemic lupus erythematosus. 61
19897521 2010
39
From brain to testis: immune escape and clonal selection in a B cell lymphoma with selective outgrowth in two immune sanctuaries [correction of sanctuariesy]. 61
17650453 2007
40
Epstein Barr virus-associated lymphoma in HIV-infected children. 61
12092768 2002

Variations for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Cosmic variations for Diffuse Large B-Cell Lymphoma of the Central Nervous System:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM83992971 haematopoietic and lymphoid tissue,central nervous system,lymphoid neoplasm,diffuse large B cell lymphoma c.586T>G p.Y196D 17:63929439-63929439 0

Expression for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Search GEO for disease gene expression data for Diffuse Large B-Cell Lymphoma of the Central Nervous System.

Pathways for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Pathways related to Diffuse Large B-Cell Lymphoma of the Central Nervous System according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.31 MYC BCL2
2
Show member pathways
12.26 MYC BCL2
3
Show member pathways
12.24 MYC BCL2
4
Show member pathways
12.18 MYC BCL2
5
Show member pathways
12.15 MYC BCL2
6
Show member pathways
12.14 MYC BCL2
7
Show member pathways
12.1 MYC BCL2
8 12.08 MYC BCL2
9
Show member pathways
12.04 MYC BCL2
10
Show member pathways
12.02 MYC BCL2
11
Show member pathways
11.95 MYC BCL2
12 11.88 MYC BCL2
13 11.82 MYC BCL2
14
Show member pathways
11.79 MYC BCL2
15 11.74 MYC BCL2
16
Show member pathways
11.66 MYC BCL2
17 11.58 MYC BCL2
18 11.57 MYC BCL2
19
Show member pathways
11.48 MYC BCL2
20 11.44 MYC BCL2
21 11.35 MYC BCL2
22
Show member pathways
11.26 MYC BCL2
23 11.19 MYC BCL2
24 11.03 MYC BCL2
25 10.97 MYC BCL2
26
Show member pathways
10.9 MYC BCL2
27 10.6 MYC BCL2
28
Show member pathways
10.3 MYC BCL2

GO Terms for Diffuse Large B-Cell Lymphoma of the Central Nervous System

Biological processes related to Diffuse Large B-Cell Lymphoma of the Central Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene expression GO:0010468 9.46 MYC BCL2
2 response to drug GO:0042493 9.43 MYC BCL2
3 cytokine-mediated signaling pathway GO:0019221 9.4 MYC BCL2
4 cell proliferation GO:0008283 9.37 MYC BCL2
5 cellular response to hypoxia GO:0071456 9.32 MYC BCL2
6 branching involved in ureteric bud morphogenesis GO:0001658 9.26 MYC BCL2
7 ovarian follicle development GO:0001541 9.16 MYC BCL2
8 response to gamma radiation GO:0010332 8.96 MYC BCL2
9 positive regulation of smooth muscle cell migration GO:0014911 8.62 MYC BCL2

Molecular functions related to Diffuse Large B-Cell Lymphoma of the Central Nervous System according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 8.96 MYC BCL2
2 repressing transcription factor binding GO:0070491 8.62 MYC BCL2

Sources for Diffuse Large B-Cell Lymphoma of the Central Nervous System

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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