MCID: DFF009
MIFTS: 22

Diffuse Lipomatosis

Categories: Skin diseases

Aliases & Classifications for Diffuse Lipomatosis

MalaCards integrated aliases for Diffuse Lipomatosis:

Name: Diffuse Lipomatosis 12 15 17 72

Classifications:



External Ids:

Disease Ontology 12 DOID:3923
NCIt 50 C6504
UMLS 72 C1333298

Summaries for Diffuse Lipomatosis

MalaCards based summary : Diffuse Lipomatosis is related to lipomatosis and goiter. An important gene associated with Diffuse Lipomatosis is BRD4 (Bromodomain Containing 4), and among its related pathways/superpathways is Chromatin Regulation / Acetylation. Affiliated tissues include thyroid, skin and colon, and related phenotypes are Increased HPV18 LCR reporter activity and Increased HPV18 LCR reporter activity

Related Diseases for Diffuse Lipomatosis

Diseases related to Diffuse Lipomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
# Related Disease Score Top Affiliating Genes
1 lipomatosis 29.9 SDHB HMGA2
2 goiter 10.2
3 lipomatosis, multiple 10.1
4 pleomorphic lipoma 10.1
5 overgrowth syndrome 10.1
6 tuberous sclerosis 10.1
7 papillary carcinoma 10.0
8 liposarcoma 10.0
9 tuberous sclerosis 1 9.8
10 paralytic poliomyelitis 9.8
11 hyperostosis 9.8
12 mesenchymal cell neoplasm 9.8
13 poliomyelitis 9.8
14 thyroiditis 9.8
15 hyperthyroidism 9.8
16 amyloidosis 9.8
17 amyloidosis aa 9.8
18 hemangioendothelioma 9.8
19 dysphagia 9.8
20 chondroma 9.2 SDHB HMGA2

Graphical network of the top 20 diseases related to Diffuse Lipomatosis:



Diseases related to Diffuse Lipomatosis

Symptoms & Phenotypes for Diffuse Lipomatosis

GenomeRNAi Phenotypes related to Diffuse Lipomatosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased HPV18 LCR reporter activity GR00197-A-1 9.26 BRD4 HMGA2
2 Increased HPV18 LCR reporter activity GR00197-A-3 9.26 BRD4
3 Increased HPV18 LCR reporter activity GR00197-A-4 9.26 BRD4
4 Increased Nanog expression GR00371-A-2 8.92 BRD4
5 Increased Nanog expression GR00371-A-4 8.92 BRD4
6 Increased Nanog expression GR00371-A-5 8.92 BRD4 HMGA2

Drugs & Therapeutics for Diffuse Lipomatosis

Search Clinical Trials , NIH Clinical Center for Diffuse Lipomatosis

Genetic Tests for Diffuse Lipomatosis

Anatomical Context for Diffuse Lipomatosis

MalaCards organs/tissues related to Diffuse Lipomatosis:

41
Thyroid, Skin, Colon, Uterus, Salivary Gland, Small Intestine

Publications for Diffuse Lipomatosis

Articles related to Diffuse Lipomatosis:

(show top 50) (show all 55)
# Title Authors PMID Year
1
Lipomatosis of spinal epidural space, peritoneum, and renal sinus: a rare complication of long-term steroid therapy in a child with nephrotic syndrome. 38
30941508 2019
2
Laparoscopic resection of large pelvic lipoma causing obstructive uropathy in a 66 year old female - A case report from Greece. 38
30317275 2018
3
An Enlarged Goiter Presenting with a Rare Diffuse Lipomatosis of the Thyroid Gland. 38
29987269 2018
4
Tuberous Sclerosis Complex and Diffuse Lipomatosis: Case Report of a Rare Association. 38
29441296 2018
5
[Nevus lipomatosus cutaneous superficialis. Report of four cases including an unusual presentation associated with massive lipomas and diffuse lipomatosis]. 38
29290322 2018
6
Multiple symmetric lipomatosis and gynecomastia: A case report and relative literature review. 38
28438575 2017
7
CT and MR imaging features of diffuse lipomatosis of the abdomen. 38
27138071 2016
8
Diffuse lipomatosis of the thyroid gland with papillary microcarcinoma: Report of a rare entity. 38
26275261 2015
9
Loss of mitochondrial SDHB expression: what is its role in diffuse thyroid lipomatosis? 38
25679879 2015
10
Diffuse lipomatosis of the chest wall: report of a neonatal case. 38
25555958 2015
11
[Diffuse lipomatosis in amyloidotic goiter]. 38
26707670 2015
12
Diffuse lipomatosis of the thyroid gland. 38
23945482 2013
13
Fat-containing salivary gland tumors: a review. 38
23821211 2013
14
Madelung's disease associated with polyneuropathy and symptomatic hypokalemia. 38
23623508 2013
15
Diffuse lipomatosis of the thyroid with amyloid deposition. 38
23339824 2013
16
First description of inhibition of let-7 microRNA expression and HMGA2 overexpression in a case of deep-seated diffuse lipomatosis. 38
22642449 2012
17
Atypical diffuse lipomatosis with multifocal abdominal involvement: a case report. 38
20541989 2010
18
Diffuse lipomatosis of thyroid with hyperthyroidism. 38
20393249 2010
19
Laryngeal lipoma associated with diffuse lipomatosis: case report and literature review. 38
20155698 2010
20
Thyrolipoma and thyrolipomatosis: 5 case reports and historical review of the literature. 38
19917474 2009
21
Madelung's disease as a rare cause of obstructive sleep apnea. 38
19918637 2009
22
Diffuse lipomatosis of the thyroid gland: a pathologic curiosity. 38
19332917 2009
23
Complicated diffuse lipomatosis mimicking ascites. 38
18358964 2008
24
Diffuse lipomatosis of thyroid gland. 38
18178906 2008
25
Giant nevi: a review. 38
17119398 2006
26
Lipomatous lesions of the parotid gland. 38
17052582 2006
27
Recurrent diffuse lipomatosis of the neck--a case report. 38
15471125 2004
28
Epidural, paraspinal, and subcutaneous lipomatosis. 38
12851798 2003
29
Diffuse lipomatosis of thyroid gland. 38
10214903 1999
30
[Dorsal transthoracic diffuse lipomatosis in a patient with familial tuberous sclerosis]. 38
9842463 1998
31
[Precordial discomfort and ECG changes of repolarization associated with hypomagnesemia in a young women following colectomy for diffuse colonic lipomatosis]. 38
9549292 1997
32
Diffuse lipomatosis: imaging features. 38
9526805 1997
33
Uterine leiomyoma with a focus of fatty and cartilaginous differentiation. 38
8389520 1993
34
[Proteus syndrome]. 38
8279789 1993
35
Diffuse lipomatosis involving the thoracic and abdominal wall: CT features. 38
1825832 1991
36
Thyroid neoplasms containing mature fat: a report of two cases and review of the literature. 38
2682616 1989
37
Multiple familial angiolipomatosis: treatment of liposuction. 38
3358622 1988
38
Diffuse lipomatosis and tuberous sclerosis. 38
3777976 1986
39
Bannayan syndrome--generalized lipomatosis associated with megalencephaly and macrodactyly. 38
3705960 1986
40
Adenolipoma of the thyroid gland. 38
3957249 1986
41
CT and histological findings of diffuse lipomatosis with a hemangioendothelioma: a case report. 38
3832955 1985
42
Lipomatous lesions of the thyroid gland: a review. 38
3842076 1985
43
Adenolipoma (thyrolipoma) of the thyroid gland report of two cases and review of literature. 38
6433552 1984
44
[Case of diffuse lipomatosis of the neck]. 38
7241980 1981
45
[Diffuse polypoid lipomatosis coli with hypertrophy of the appendices epiploicae in congenital lipomatosis (author's transl)]. 38
7439059 1980
46
Lipomatous lesions of the uterus. 38
150107 1978
47
Different clinical types of lipomatosis. Case report. 38
663569 1978
48
[Diffuse entero-mesenteric lipomatosis]. 38
854206 1977
49
Diffuse lipomatosis in the leg after poliomyelitis. 38
1155102 1975
50
[Diffuse lipomatosis of Launois and Bensaude (apropos of 5 personal case)]. 38
5157740 1971

Variations for Diffuse Lipomatosis

Expression for Diffuse Lipomatosis

Search GEO for disease gene expression data for Diffuse Lipomatosis.

Pathways for Diffuse Lipomatosis

Pathways related to Diffuse Lipomatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.03 HMGA2 BRD4

GO Terms for Diffuse Lipomatosis

Cellular components related to Diffuse Lipomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 8.8 SDHB HMGA2 BRD4

Biological processes related to Diffuse Lipomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 8.96 HMGA2 BRD4
2 chromatin organization GO:0006325 8.62 HMGA2 BRD4

Sources for Diffuse Lipomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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