MCID: DFF013
MIFTS: 24

Diffuse Meningeal Melanocytosis

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Diffuse Meningeal Melanocytosis

MalaCards integrated aliases for Diffuse Meningeal Melanocytosis:

Name: Diffuse Meningeal Melanocytosis 12 15
Diffuse Melanocytosis 12 73
Diffuse Melanosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6379
NCIt 50 C6890
SNOMED-CT 68 128729004
UMLS 73 C1266112

Summaries for Diffuse Meningeal Melanocytosis

MalaCards based summary : Diffuse Meningeal Melanocytosis, also known as diffuse melanocytosis, is related to vulvar melanoma and malignant spindle cell melanoma, and has symptoms including seizures An important gene associated with Diffuse Meningeal Melanocytosis is ZIC1 (Zic Family Member 1), and among its related pathways/superpathways is Lung fibrosis. Affiliated tissues include placenta, and related phenotype is no phenotypic analysis.

Related Diseases for Diffuse Meningeal Melanocytosis

Diseases related to Diffuse Meningeal Melanocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
# Related Disease Score Top Affiliating Genes
1 vulvar melanoma 30.0 MLANA TYR
2 malignant spindle cell melanoma 10.6 PMEL TYR
3 gallbladder melanoma 10.4 MLANA PMEL
4 hermansky-pudlak syndrome 3 10.4 PMEL TYR
5 melanocytic nevus syndrome, congenital 10.4 EDN1 TYR
6 pigmented basal cell carcinoma 10.4 MLANA TYR
7 acute kidney tubular necrosis 10.4 HGF TYR
8 dowling-degos disease 1 10.4 EDN1 TYR
9 epithelioid cell melanoma 10.4 MLANA TYR
10 deep angioma 10.3 CD34 TYR
11 intramuscular hemangioma 10.3 CD34 TYR
12 malignant skin fibrous histiocytoma 10.3 MLANA TYR
13 acute kidney failure 10.2 HGF TYR
14 malignant dermis tumor 10.2 MLANA TYR
15 vogt-koyanagi-harada disease 10.2 PMEL TYR
16 spindle cell synovial sarcoma 10.2 CD34 HGF
17 spindle cell liposarcoma 10.1 CD34 MLANA
18 limb ischemia 10.1 EDN1 HGF
19 erythema elevatum diutinum 10.1 CD34 S100A9
20 halo nevi 10.0 MLANA PMEL TYR
21 melanoacanthoma 10.0 MLANA PMEL TYR
22 integumentary system cancer 10.0 MLANA TYR
23 vitiligo-associated multiple autoimmune disease susceptibility 1 10.0 MLANA PMEL TYR
24 melanoma, uveal 10.0 MLANA PMEL TYR
25 skin melanoma 10.0 MLANA PMEL TYR
26 obstructive jaundice 9.9 EDN1 HGF
27 retina lymphoma 9.9 CD34 CD68
28 balloon cell malignant melanoma 9.9 CD68 MLANA
29 extracutaneous mastocytoma 9.9 CD34 CD68
30 sternum cancer 9.9 CD34 CD68
31 melanoma 9.9
32 glomeruloid hemangioma 9.8 CD34 CD68
33 brain sarcoma 9.8 CD68 MLANA
34 hemangioma of liver 9.8 CD34 CD68
35 optic nerve disease 9.8 EDN1 TYR
36 sarcomatoid squamous cell skin carcinoma 9.8 CD34 CD68
37 spleen cancer 9.8 CD34 CD68
38 conventional fibrosarcoma 9.8 CD34 CD68
39 breast angiosarcoma 9.8 CD34 MLANA TYR
40 mixed liposarcoma 9.8 CD34 CD68
41 ischemic fasciitis 9.8 CD34 CD68
42 meningeal melanocytoma 9.8 CD68 MLANA
43 aleukemic leukemia cutis 9.8 CD34 CD68
44 verruciform xanthoma of skin 9.8 CD68 S100A9
45 nodular tenosynovitis 9.7 CD68 S100A9
46 hemangioma of intra-abdominal structure 9.7 CD34 CD68
47 myxosarcoma 9.7 CD68 MLANA
48 microphthalmia 9.7 MLANA PMEL TYR
49 skin sarcoma 9.7 CD34 CD68
50 clear cell ependymoma 9.6 CD34 CD68

Graphical network of the top 20 diseases related to Diffuse Meningeal Melanocytosis:



Diseases related to Diffuse Meningeal Melanocytosis

Symptoms & Phenotypes for Diffuse Meningeal Melanocytosis

UMLS symptoms related to Diffuse Meningeal Melanocytosis:


seizures

MGI Mouse Phenotypes related to Diffuse Meningeal Melanocytosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.02 CD68 HGF MLANA PMEL TYR

Drugs & Therapeutics for Diffuse Meningeal Melanocytosis

Search Clinical Trials , NIH Clinical Center for Diffuse Meningeal Melanocytosis

Genetic Tests for Diffuse Meningeal Melanocytosis

Anatomical Context for Diffuse Meningeal Melanocytosis

MalaCards organs/tissues related to Diffuse Meningeal Melanocytosis:

41
Placenta

Publications for Diffuse Meningeal Melanocytosis

Articles related to Diffuse Meningeal Melanocytosis:

# Title Authors Year
1
Diffuse melanosis after chemotherapy-induced tumor lysis syndrome in a patient with metastatic melanoma. ( 14984582 )
2004
2
Vulvar melanoma: diffuse melanosis and metastasis to the placenta. ( 14726891 )
2004

Variations for Diffuse Meningeal Melanocytosis

Expression for Diffuse Meningeal Melanocytosis

Search GEO for disease gene expression data for Diffuse Meningeal Melanocytosis.

Pathways for Diffuse Meningeal Melanocytosis

Pathways related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.42 EDN1 HGF

GO Terms for Diffuse Meningeal Melanocytosis

Cellular components related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome GO:0042470 8.8 MLANA PMEL TYR

Biological processes related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.58 CD34 HGF TYR
2 regulation of blood pressure GO:0008217 9.37 CD34 EDN1
3 neutrophil chemotaxis GO:0030593 9.32 EDN1 S100A9
4 positive regulation of interleukin-10 production GO:0032733 9.26 CD34 HGF
5 negative regulation of blood coagulation GO:0030195 9.16 CD34 EDN1
6 melanin biosynthetic process GO:0042438 8.96 PMEL TYR
7 positive regulation of odontogenesis GO:0042482 8.62 CD34 EDN1

Sources for Diffuse Meningeal Melanocytosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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