Diffuse Meningeal Melanocytosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Diffuse Meningeal Melanocytosis

MalaCards integrated aliases for Diffuse Meningeal Melanocytosis:

Name: Diffuse Meningeal Melanocytosis ¹² ¹⁵

Diffuse Melanocytosis ¹² ⁷³

Diffuse Melanosis ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6379

NCIt ⁵⁰ C6890

SNOMED-CT ⁶⁸ 128729004

UMLS ⁷³ C1266112

Sources

Summaries for Diffuse Meningeal Melanocytosis

MalaCards based summary : Diffuse Meningeal Melanocytosis, also known as diffuse melanocytosis, is related to vulvar melanoma and malignant spindle cell melanoma, and has symptoms including seizures An important gene associated with Diffuse Meningeal Melanocytosis is ZIC1 (Zic Family Member 1), and among its related pathways/superpathways is Lung fibrosis. Affiliated tissues include placenta, and related phenotype is no phenotypic analysis.

Sources

Related Diseases for Diffuse Meningeal Melanocytosis

Diseases related to Diffuse Meningeal Melanocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)

#	Related Disease	Score	Top Affiliating Genes
1	vulvar melanoma	30.0	MLANA TYR
2	malignant spindle cell melanoma	10.6	PMEL TYR
3	gallbladder melanoma	10.4	MLANA PMEL
4	hermansky-pudlak syndrome 3	10.4	PMEL TYR
5	melanocytic nevus syndrome, congenital	10.4	EDN1 TYR
6	pigmented basal cell carcinoma	10.4	MLANA TYR
7	acute kidney tubular necrosis	10.4	HGF TYR
8	dowling-degos disease 1	10.4	EDN1 TYR
9	epithelioid cell melanoma	10.4	MLANA TYR
10	deep angioma	10.3	CD34 TYR
11	intramuscular hemangioma	10.3	CD34 TYR
12	malignant skin fibrous histiocytoma	10.3	MLANA TYR
13	acute kidney failure	10.2	HGF TYR
14	malignant dermis tumor	10.2	MLANA TYR
15	vogt-koyanagi-harada disease	10.2	PMEL TYR
16	spindle cell synovial sarcoma	10.2	CD34 HGF
17	spindle cell liposarcoma	10.1	CD34 MLANA
18	limb ischemia	10.1	EDN1 HGF
19	erythema elevatum diutinum	10.1	CD34 S100A9
20	halo nevi	10.0	MLANA PMEL TYR
21	melanoacanthoma	10.0	MLANA PMEL TYR
22	integumentary system cancer	10.0	MLANA TYR
23	vitiligo-associated multiple autoimmune disease susceptibility 1	10.0	MLANA PMEL TYR
24	melanoma, uveal	10.0	MLANA PMEL TYR
25	skin melanoma	10.0	MLANA PMEL TYR
26	obstructive jaundice	9.9	EDN1 HGF
27	retina lymphoma	9.9	CD34 CD68
28	balloon cell malignant melanoma	9.9	CD68 MLANA
29	extracutaneous mastocytoma	9.9	CD34 CD68
30	sternum cancer	9.9	CD34 CD68
31	melanoma	9.9
32	glomeruloid hemangioma	9.8	CD34 CD68
33	brain sarcoma	9.8	CD68 MLANA
34	hemangioma of liver	9.8	CD34 CD68
35	optic nerve disease	9.8	EDN1 TYR
36	sarcomatoid squamous cell skin carcinoma	9.8	CD34 CD68
37	spleen cancer	9.8	CD34 CD68
38	conventional fibrosarcoma	9.8	CD34 CD68
39	breast angiosarcoma	9.8	CD34 MLANA TYR
40	mixed liposarcoma	9.8	CD34 CD68
41	ischemic fasciitis	9.8	CD34 CD68
42	meningeal melanocytoma	9.8	CD68 MLANA
43	aleukemic leukemia cutis	9.8	CD34 CD68
44	verruciform xanthoma of skin	9.8	CD68 S100A9
45	nodular tenosynovitis	9.7	CD68 S100A9
46	hemangioma of intra-abdominal structure	9.7	CD34 CD68
47	myxosarcoma	9.7	CD68 MLANA
48	microphthalmia	9.7	MLANA PMEL TYR
49	skin sarcoma	9.7	CD34 CD68
50	clear cell ependymoma	9.6	CD34 CD68

Graphical network of the top 20 diseases related to Diffuse Meningeal Melanocytosis:

Sources

Symptoms & Phenotypes for Diffuse Meningeal Melanocytosis

UMLS symptoms related to Diffuse Meningeal Melanocytosis:

seizures

MGI Mouse Phenotypes related to Diffuse Meningeal Melanocytosis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	no phenotypic analysis	MP:0003012	9.02	CD68 HGF MLANA PMEL TYR

Sources

Drugs & Therapeutics for Diffuse Meningeal Melanocytosis

Search Clinical Trials , NIH Clinical Center for Diffuse Meningeal Melanocytosis

Sources

Genetic Tests for Diffuse Meningeal Melanocytosis

Sources

Anatomical Context for Diffuse Meningeal Melanocytosis

MalaCards organs/tissues related to Diffuse Meningeal Melanocytosis:

⁴¹

Placenta

Sources

Publications for Diffuse Meningeal Melanocytosis

Articles related to Diffuse Meningeal Melanocytosis:

#	Title	Authors	Year
1	Diffuse melanosis after chemotherapy-induced tumor lysis syndrome in a patient with metastatic melanoma. ( 14984582 )	Busam K.J....CHAPMAN P.	2004
2	Vulvar melanoma: diffuse melanosis and metastasis to the placenta. ( 14726891 )	Alexander A....Leachman S.A.	2004

Sources

Genes for Diffuse Meningeal Melanocytosis

Genes related to Diffuse Meningeal Melanocytosis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ZIC1	Zic Family Member 1	Protein Coding	15.89	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	PMEL	Premelanosome Protein	Protein Coding	14.74	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	TYR	Tyrosinase	Protein Coding	14.41	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	HGF	Hepatocyte Growth Factor	Protein Coding	14.04	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	EDN1	Endothelin 1	Protein Coding	13.5	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	MLANA	Melan-A	Protein Coding	5.36	DISEASES inferred ¹⁵
7	S100A9	S100 Calcium Binding Protein A9	Protein Coding	4.88	DISEASES inferred ¹⁵
8	CD68	CD68 Molecule	Protein Coding	4.55	DISEASES inferred ¹⁵
9	CD34	CD34 Molecule	Protein Coding	3.05	DISEASES inferred ¹⁵

Sources

Variations for Diffuse Meningeal Melanocytosis

Sources

Expression for Diffuse Meningeal Melanocytosis

Search GEO for disease gene expression data for Diffuse Meningeal Melanocytosis.

Sources

Pathways for Diffuse Meningeal Melanocytosis

Pathways related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Lung fibrosis ¹	10.42	EDN1 HGF

Sources

GO Terms for Diffuse Meningeal Melanocytosis

Cellular components related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	melanosome	GO:0042470	8.8	MLANA PMEL TYR

Biological processes related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell proliferation	GO:0008283	9.58	CD34 HGF TYR
2	regulation of blood pressure	GO:0008217	9.37	CD34 EDN1
3	neutrophil chemotaxis	GO:0030593	9.32	EDN1 S100A9
4	positive regulation of interleukin-10 production	GO:0032733	9.26	CD34 HGF
5	negative regulation of blood coagulation	GO:0030195	9.16	CD34 EDN1
6	melanin biosynthetic process	GO:0042438	8.96	PMEL TYR
7	positive regulation of odontogenesis	GO:0042482	8.62	CD34 EDN1

Sources

Sources for Diffuse Meningeal Melanocytosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia