MCID: DFF013
MIFTS: 24

Diffuse Meningeal Melanocytosis

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Diffuse Meningeal Melanocytosis

MalaCards integrated aliases for Diffuse Meningeal Melanocytosis:

Name: Diffuse Meningeal Melanocytosis 12 15
Diffuse Melanocytosis 12 17 72
Diffuse Melanosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6379
NCIt 50 C6890
UMLS 72 C1266112

Summaries for Diffuse Meningeal Melanocytosis

MalaCards based summary : Diffuse Meningeal Melanocytosis, also known as diffuse melanocytosis, is related to dowling-degos disease 1 and vulvar melanoma, and has symptoms including seizures An important gene associated with Diffuse Meningeal Melanocytosis is ZIC1 (Zic Family Member 1), and among its related pathways/superpathways is Lung fibrosis. Affiliated tissues include brain, and related phenotype is no phenotypic analysis.

Related Diseases for Diffuse Meningeal Melanocytosis

Diseases related to Diffuse Meningeal Melanocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 dowling-degos disease 1 30.4 TYR EDN1
2 vulvar melanoma 30.1 TYR MLANA
3 skin melanoma 29.8 TYR PMEL
4 melanoma 10.4
5 malignant spindle cell melanoma 10.4 TYR PMEL
6 vitiligo-associated multiple autoimmune disease susceptibility 6 10.4 TYR PMEL
7 gallbladder melanoma 10.3 PMEL MLANA
8 acute kidney tubular necrosis 10.3 TYR HGF
9 melanocytic nevus syndrome, congenital 10.3 TYR EDN1
10 hermansky-pudlak syndrome 3 10.3 TYR PMEL
11 pigmented basal cell carcinoma 10.2 TYR MLANA
12 deep angioma 10.2 TYR CD34
13 epithelioid cell melanoma 10.2 TYR MLANA
14 vitiligo-associated multiple autoimmune disease susceptibility 1 10.2 TYR PMEL
15 intramuscular hemangioma 10.2 TYR CD34
16 spindle cell synovial sarcoma 10.2 HGF CD34
17 acute kidney failure 10.2 TYR HGF
18 malignant skin fibrous histiocytoma 10.2 TYR MLANA
19 malignant dermis tumor 10.1 TYR MLANA
20 spindle cell liposarcoma 10.1 MLANA CD34
21 limb ischemia 10.1 HGF EDN1
22 vogt-koyanagi-harada disease 10.1 TYR PMEL
23 obstructive jaundice 10.1 HGF EDN1
24 halo nevi 10.0 TYR PMEL MLANA
25 melanoacanthoma 10.0 TYR PMEL MLANA
26 melanoma, uveal 9.9 TYR PMEL MLANA
27 retina lymphoma 9.9 CD68 CD34
28 balloon cell malignant melanoma 9.9 MLANA CD68
29 sternum cancer 9.9 CD68 CD34
30 extracutaneous mastocytoma 9.9 CD68 CD34
31 brain sarcoma 9.9 MLANA CD68
32 glomeruloid hemangioma 9.9 CD68 CD34
33 spleen cancer 9.9 CD68 CD34
34 colorectal cancer 9.9
35 nodular malignant melanoma 9.9
36 hemopericardium 9.9
37 pericardial effusion 9.9
38 neurilemmoma 9.9
39 acral lentiginous melanoma 9.9
40 placenta disease 9.9
41 48,xyyy 9.9
42 hemangioma of liver 9.9 CD68 CD34
43 conventional fibrosarcoma 9.9 CD68 CD34
44 mixed liposarcoma 9.8 CD68 CD34
45 ischemic fasciitis 9.8 CD68 CD34
46 aleukemic leukemia cutis 9.8 CD68 CD34
47 myxosarcoma 9.8 MLANA CD68
48 breast angiosarcoma 9.8 TYR MLANA CD34
49 meningeal melanocytoma 9.8 MLANA CD68
50 hemangioma of intra-abdominal structure 9.8 CD68 CD34

Graphical network of the top 20 diseases related to Diffuse Meningeal Melanocytosis:



Diseases related to Diffuse Meningeal Melanocytosis

Symptoms & Phenotypes for Diffuse Meningeal Melanocytosis

UMLS symptoms related to Diffuse Meningeal Melanocytosis:


seizures

MGI Mouse Phenotypes related to Diffuse Meningeal Melanocytosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.02 CD68 HGF MLANA PMEL TYR

Drugs & Therapeutics for Diffuse Meningeal Melanocytosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Identification of Compound Isolated From Cock's Comb and Its Effect on Arsenical Palmar Keratosis Recruiting NCT03635853 Phase 2 drug containing extract from cock's comb

Search NIH Clinical Center for Diffuse Meningeal Melanocytosis

Genetic Tests for Diffuse Meningeal Melanocytosis

Anatomical Context for Diffuse Meningeal Melanocytosis

MalaCards organs/tissues related to Diffuse Meningeal Melanocytosis:

41
Brain

Publications for Diffuse Meningeal Melanocytosis

Articles related to Diffuse Meningeal Melanocytosis:

# Title Authors PMID Year
1
Neurocutaneous Melanosis in an Adult Patient with Intracranial Primary Malignant Melanoma: Case Report and Review of the Literature. 38
29530698 2018
2
An uncommon mimic of spontaneous subarachnoid haemorrhage. 38
23378361 2013
3
Primary melanocytic tumors of the central nervous system: a neuroradiological and clinicopathological study of five cases and brief review of literature. 38
21743173 2011
4
Black brain: transformation of a melanocytoma with diffuse melanocytosis into a primary cerebral melanoma. 38
20640479 2011
5
Pigmented lesions of the central nervous system: radiologic-pathologic correlation. 38
19755608 2009
6
Progressive brainstem compression in an infant with neurocutaneous melanosis and Dandy-Walker complex following ventriculoperitoneal shunt placement for hydrocephalus. Case report. 38
18154021 2007
7
Primary melanocytic lesions of the CNS: report of five cases. 38
15306980 2004
8
Glaucoma in phakomatosis pigmentovascularis. 38
9022120 1997

Variations for Diffuse Meningeal Melanocytosis

Expression for Diffuse Meningeal Melanocytosis

Search GEO for disease gene expression data for Diffuse Meningeal Melanocytosis.

Pathways for Diffuse Meningeal Melanocytosis

Pathways related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.42 HGF EDN1

GO Terms for Diffuse Meningeal Melanocytosis

Cellular components related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome GO:0042470 8.8 TYR PMEL MLANA

Biological processes related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.37 TYR CD34
2 regulation of blood pressure GO:0008217 9.32 EDN1 CD34
3 positive regulation of interleukin-10 production GO:0032733 9.26 HGF CD34
4 negative regulation of blood coagulation GO:0030195 9.16 EDN1 CD34
5 melanin biosynthetic process GO:0042438 8.96 TYR PMEL
6 positive regulation of odontogenesis GO:0042482 8.62 EDN1 CD34

Sources for Diffuse Meningeal Melanocytosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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