Diffuse Meningeal Melanocytosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Diffuse Meningeal Melanocytosis

MalaCards integrated aliases for Diffuse Meningeal Melanocytosis:

Name: Diffuse Meningeal Melanocytosis ¹² ¹⁵

Diffuse Melanocytosis ¹² ¹⁷ ⁷⁴

Diffuse Melanosis ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6379

NCIt ⁵¹ C6890

EFO ¹⁷ EFO_1000216

UMLS ⁷⁴ C1266112

Sources

Summaries for Diffuse Meningeal Melanocytosis

MalaCards based summary : Diffuse Meningeal Melanocytosis, also known as diffuse melanocytosis, is related to vulvar melanoma and malignant spindle cell melanoma, and has symptoms including seizures An important gene associated with Diffuse Meningeal Melanocytosis is ZIC1 (Zic Family Member 1), and among its related pathways/superpathways is Lung fibrosis. Affiliated tissues include skin, brain and kidney, and related phenotype is no phenotypic analysis.

Sources

Related Diseases for Diffuse Meningeal Melanocytosis

Diseases related to Diffuse Meningeal Melanocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)

#	Related Disease	Score	Top Affiliating Genes
1	vulvar melanoma	30.0	MLANA TYR
2	malignant spindle cell melanoma	10.3	PMEL TYR
3	vitiligo-associated multiple autoimmune disease susceptibility 6	10.3	PMEL TYR
4	gallbladder melanoma	10.2	MLANA PMEL
5	hermansky-pudlak syndrome 3	10.2	PMEL TYR
6	melanocytic nevus syndrome, congenital	10.2	EDN1 TYR
7	acute kidney tubular necrosis	10.2	HGF TYR
8	pigmented basal cell carcinoma	10.2	MLANA TYR
9	dowling-degos disease 1	10.2	EDN1 TYR
10	vitiligo-associated multiple autoimmune disease susceptibility 1	10.2	PMEL TYR
11	epithelioid cell melanoma	10.2	MLANA TYR
12	deep angioma	10.2	CD34 TYR
13	intramuscular hemangioma	10.2	CD34 TYR
14	malignant skin fibrous histiocytoma	10.1	MLANA TYR
15	acute kidney failure	10.1	HGF TYR
16	vogt-koyanagi-harada disease	10.1	PMEL TYR
17	malignant dermis tumor	10.1	MLANA TYR
18	spindle cell synovial sarcoma	10.1	CD34 HGF
19	spindle cell liposarcoma	10.1	CD34 MLANA
20	limb ischemia	10.0	EDN1 HGF
21	skin melanoma	10.0	PMEL TYR
22	melanomatosis	10.0	CD68 CWC22
23	halo nevi	10.0	MLANA PMEL TYR
24	melanoacanthoma	10.0	MLANA PMEL TYR
25	obstructive jaundice	10.0	EDN1 HGF
26	melanoma, uveal	10.0	MLANA PMEL TYR
27	retina lymphoma	9.9	CD34 CD68
28	balloon cell malignant melanoma	9.9	CD68 MLANA
29	extracutaneous mastocytoma	9.9	CD34 CD68
30	sternum cancer	9.9	CD34 CD68
31	brain sarcoma	9.9	CD68 MLANA
32	glomeruloid hemangioma	9.9	CD34 CD68
33	hemangioma of liver	9.9	CD34 CD68
34	spleen cancer	9.9	CD34 CD68
35	melanoma	9.9
36	conventional fibrosarcoma	9.9	CD34 CD68
37	mixed liposarcoma	9.9	CD34 CD68
38	breast angiosarcoma	9.9	CD34 MLANA TYR
39	ischemic fasciitis	9.9	CD34 CD68
40	myxosarcoma	9.9	CD68 MLANA
41	microphthalmia	9.9	MLANA PMEL TYR
42	aleukemic leukemia cutis	9.9	CD34 CD68
43	nodular tenosynovitis	9.9	CD68 S100A9
44	hemangioma of intra-abdominal structure	9.9	CD34 CD68
45	hemopericardium	9.9
46	pericardial effusion	9.9
47	skin sarcoma	9.8	CD34 CD68
48	idiopathic interstitial pneumonia	9.8	CD34 EDN1
49	optic nerve disease	9.8	EDN1 TYR
50	connective tissue cancer	9.8	CD34 CD68

Graphical network of the top 20 diseases related to Diffuse Meningeal Melanocytosis:

Sources

Symptoms & Phenotypes for Diffuse Meningeal Melanocytosis

UMLS symptoms related to Diffuse Meningeal Melanocytosis:

seizures

MGI Mouse Phenotypes related to Diffuse Meningeal Melanocytosis:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	no phenotypic analysis	MP:0003012	9.02	CD68 HGF MLANA PMEL TYR

Sources

Drugs & Therapeutics for Diffuse Meningeal Melanocytosis

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Identification of Compound Isolated From Cock's Comb and Its Effect on Arsenical Palmar Keratosis	Recruiting	NCT03635853	Phase 2	drug containing extract from cock's comb

Search NIH Clinical Center for Diffuse Meningeal Melanocytosis

Sources

Genetic Tests for Diffuse Meningeal Melanocytosis

Sources

Anatomical Context for Diffuse Meningeal Melanocytosis

MalaCards organs/tissues related to Diffuse Meningeal Melanocytosis:

⁴²

Skin, Brain, Kidney, Liver, Breast, Spleen, Retina

Sources

Publications for Diffuse Meningeal Melanocytosis

Articles related to Diffuse Meningeal Melanocytosis:

#	Title	Authors	Year
1	Black brain: transformation of a melanocytoma with diffuse melanocytosis into a primary cerebral melanoma. ( 20640479 )	Gempt J...Ringel F	2011

Sources

Genes for Diffuse Meningeal Melanocytosis

Genes related to Diffuse Meningeal Melanocytosis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ZIC1	Zic Family Member 1	Protein Coding	15.72	DISEASES inferred ¹⁵
2	CWC22	CWC22 Spliceosome Associated Protein Homolog	Protein Coding	15.43	DISEASES inferred ¹⁵
3	PMEL	Premelanosome Protein	Protein Coding	14.69	DISEASES inferred ¹⁵
4	TYR	Tyrosinase	Protein Coding	14.34	DISEASES inferred ¹⁵
5	HGF	Hepatocyte Growth Factor	Protein Coding	13.86	DISEASES inferred ¹⁵
6	EDN1	Endothelin 1	Protein Coding	13.43	DISEASES inferred ¹⁵
7	MLANA	Melan-A	Protein Coding	5.23	DISEASES inferred ¹⁵
8	S100A9	S100 Calcium Binding Protein A9	Protein Coding	4.76	DISEASES inferred ¹⁵
9	CD68	CD68 Molecule	Protein Coding	4.42	DISEASES inferred ¹⁵
10	CD34	CD34 Molecule	Protein Coding	2.94	DISEASES inferred ¹⁵

Sources

Variations for Diffuse Meningeal Melanocytosis

Sources

Expression for Diffuse Meningeal Melanocytosis

Search GEO for disease gene expression data for Diffuse Meningeal Melanocytosis.

Sources

Pathways for Diffuse Meningeal Melanocytosis

Pathways related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Lung fibrosis ¹	10.42	EDN1 HGF

Sources

GO Terms for Diffuse Meningeal Melanocytosis

Cellular components related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	melanosome	GO:0042470	8.8	MLANA PMEL TYR

Biological processes related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of blood pressure	GO:0008217	9.32	CD34 EDN1
2	positive regulation of interleukin-10 production	GO:0032733	9.26	CD34 HGF
3	negative regulation of blood coagulation	GO:0030195	9.16	CD34 EDN1
4	melanin biosynthetic process	GO:0042438	8.96	PMEL TYR
5	positive regulation of odontogenesis	GO:0042482	8.62	CD34 EDN1

Sources

Sources for Diffuse Meningeal Melanocytosis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia