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MCID: DFF013
MIFTS: 20

Diffuse Meningeal Melanocytosis

Categories: Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Diffuse Meningeal Melanocytosis

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MalaCards integrated aliases for Diffuse Meningeal Melanocytosis:

Name: Diffuse Meningeal Melanocytosis 12 15
Diffuse Melanocytosis 12 17 71
Diffuse Melanosis 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:6379
NCIt 49 C6890
SNOMED-CT 67 128729004
UMLS 71 C1266112
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Summaries for Diffuse Meningeal Melanocytosis

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MalaCards based summary : Diffuse Meningeal Melanocytosis, also known as diffuse melanocytosis, is related to neurilemmoma and dowling-degos disease 1, and has symptoms including seizures An important gene associated with Diffuse Meningeal Melanocytosis is MLANA (Melan-A), and among its related pathways/superpathways is Tyrosine metabolism. Affiliated tissues include brain, and related phenotype is no phenotypic analysis.

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Related Diseases for Diffuse Meningeal Melanocytosis

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Diseases related to Diffuse Meningeal Melanocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 neurilemmoma 29.9 TYR MLANA
2 dowling-degos disease 1 29.9 TYR POMC
3 nodular malignant melanoma 29.8 TYR MLANA
4 melanoma, cutaneous malignant 10 10.4
5 melanoma 10.4
6 meningeal melanocytoma 10.3 MLANA MIB1
7 central nervous system melanocytic neoplasm 10.3 MLANA MIB1
8 melanotic neurilemmoma 10.1 POMC MLANA
9 olfactory nerve neoplasm 10.1 POMC MLANA
10 cranial nerve malignant neoplasm 10.1 POMC MLANA
11 cranial nerve neoplasm 10.1 POMC MLANA
12 sex cord-gonadal stromal tumor 10.1 POMC MLANA
13 ciliary body cancer 10.1 TYR MLANA
14 halo nevi 10.1 TYR MLANA
15 melanoacanthoma 10.1 TYR MLANA
16 sarcomatoid transitional cell carcinoma 10.1 TYR MLANA
17 epithelioid cell melanoma 10.1 TYR MLANA
18 adrenal cortex disease 10.1 POMC MLANA
19 adrenal cortical carcinoma 10.0 POMC MLANA
20 malignant spindle cell melanoma 10.0 TYR MLANA
21 orofacial cleft 8 10.0 TYR MLANA
22 adrenal cortical adenoma 10.0 POMC MLANA
23 carney complex variant 10.0 POMC MLANA
24 amelanotic melanoma 10.0 TYR MLANA
25 autoimmune disease of skin and connective tissue 10.0 TYR MLANA
26 melanoma in congenital melanocytic nevus 10.0 TYR MLANA
27 angiomyolipoma 9.9 TYR MLANA
28 colorectal cancer 9.9
29 hemopericardium 9.9
30 pericardial effusion 9.9
31 vulvar melanoma 9.9
32 acral lentiginous melanoma 9.9
33 placenta disease 9.9
34 skin melanoma 9.9
35 48,xyyy 9.9
36 large congenital melanocytic nevus 9.9 MLANA HGF
37 ocular albinism 9.9 TYR MLANA
38 osseous heteroplasia, progressive 9.8 TYR POMC
39 lentigines 9.7 TYR POMC MLANA
40 vitiligo-associated multiple autoimmune disease susceptibility 1 9.7 TYR POMC MLANA
41 drug dependence 9.7 POMC ADH1B
42 acute kidney tubular necrosis 9.6 TYR HGF
43 skin carcinoma 9.6 TYR POMC MLANA
44 dry eye syndrome 9.6 S100A9 HGF
45 alcoholic liver cirrhosis 9.6 HGF ADH1B
46 acute kidney failure 9.5 TYR HGF
47 spinal cord melanoma 9.5 TYR MLANA HGF
48 neurofibroma 9.5 TYR MLANA HGF
49 melanoma, uveal 9.4 TYR MLANA HGF
50 microphthalmia 9.4 TYR POMC MLANA

Graphical network of the top 20 diseases related to Diffuse Meningeal Melanocytosis:



Diseases related to Diffuse Meningeal Melanocytosis
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Symptoms & Phenotypes for Diffuse Meningeal Melanocytosis

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UMLS symptoms related to Diffuse Meningeal Melanocytosis:


seizures

MGI Mouse Phenotypes related to Diffuse Meningeal Melanocytosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.02 HGF MIB1 MLANA POMC TYR
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Drugs & Therapeutics for Diffuse Meningeal Melanocytosis

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Identification of Compound Isolated From Cock's Comb and Its Effect on Arsenical Palmar Keratosis Recruiting NCT03635853 Phase 2 drug containing extract from cock's comb

Search NIH Clinical Center for Diffuse Meningeal Melanocytosis

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Genetic Tests for Diffuse Meningeal Melanocytosis

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Anatomical Context for Diffuse Meningeal Melanocytosis

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MalaCards organs/tissues related to Diffuse Meningeal Melanocytosis:

40
Brain
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Publications for Diffuse Meningeal Melanocytosis

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Articles related to Diffuse Meningeal Melanocytosis:

# Title Authors PMID Year
1
C6-T1 Intradural Extramedullary Ventral Meningeal Melanocytoma Resected Via Anterior Corpectomy with Reconstruction. 61
32251820 2020
2
Neurocutaneous Melanosis in an Adult Patient with Intracranial Primary Malignant Melanoma: Case Report and Review of the Literature. 61
29530698 2018
3
An uncommon mimic of spontaneous subarachnoid haemorrhage. 61
23378361 2013
4
Primary melanocytic tumors of the central nervous system: a neuroradiological and clinicopathological study of five cases and brief review of literature. 61
21743173 2011
5
Black brain: transformation of a melanocytoma with diffuse melanocytosis into a primary cerebral melanoma. 61
20640479 2011
6
Pigmented lesions of the central nervous system: radiologic-pathologic correlation. 61
19755608 2009
7
Progressive brainstem compression in an infant with neurocutaneous melanosis and Dandy-Walker complex following ventriculoperitoneal shunt placement for hydrocephalus. Case report. 61
18154021 2007
8
Primary melanocytic lesions of the CNS: report of five cases. 61
15306980 2004
9
Glaucoma in phakomatosis pigmentovascularis. 61
9022120 1997
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Variations for Diffuse Meningeal Melanocytosis

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Expression for Diffuse Meningeal Melanocytosis

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Search GEO for disease gene expression data for Diffuse Meningeal Melanocytosis.
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Pathways for Diffuse Meningeal Melanocytosis

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Pathways related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Tyrosine metabolism 36
Show member pathways
 10.5 TYR ADH1B
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GO Terms for Diffuse Meningeal Melanocytosis

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Sources for Diffuse Meningeal Melanocytosis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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