MCID: DFF013
MIFTS: 23

Diffuse Meningeal Melanocytosis

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Diffuse Meningeal Melanocytosis

MalaCards integrated aliases for Diffuse Meningeal Melanocytosis:

Name: Diffuse Meningeal Melanocytosis 12 15
Diffuse Melanocytosis 12 17 74
Diffuse Melanosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6379
NCIt 51 C6890
UMLS 74 C1266112

Summaries for Diffuse Meningeal Melanocytosis

MalaCards based summary : Diffuse Meningeal Melanocytosis, also known as diffuse melanocytosis, is related to vulvar melanoma and malignant spindle cell melanoma, and has symptoms including seizures An important gene associated with Diffuse Meningeal Melanocytosis is ZIC1 (Zic Family Member 1), and among its related pathways/superpathways is Lung fibrosis. Affiliated tissues include brain, and related phenotype is no phenotypic analysis.

Related Diseases for Diffuse Meningeal Melanocytosis

Diseases related to Diffuse Meningeal Melanocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 vulvar melanoma 30.0 MLANA TYR
2 malignant spindle cell melanoma 10.3 PMEL TYR
3 vitiligo-associated multiple autoimmune disease susceptibility 6 10.3 PMEL TYR
4 gallbladder melanoma 10.2 MLANA PMEL
5 hermansky-pudlak syndrome 3 10.2 PMEL TYR
6 melanocytic nevus syndrome, congenital 10.2 EDN1 TYR
7 acute kidney tubular necrosis 10.2 HGF TYR
8 pigmented basal cell carcinoma 10.2 MLANA TYR
9 dowling-degos disease 1 10.2 EDN1 TYR
10 vitiligo-associated multiple autoimmune disease susceptibility 1 10.2 PMEL TYR
11 epithelioid cell melanoma 10.2 MLANA TYR
12 deep angioma 10.2 CD34 TYR
13 intramuscular hemangioma 10.1 CD34 TYR
14 malignant skin fibrous histiocytoma 10.1 MLANA TYR
15 acute kidney failure 10.1 HGF TYR
16 vogt-koyanagi-harada disease 10.1 PMEL TYR
17 malignant dermis tumor 10.1 MLANA TYR
18 spindle cell synovial sarcoma 10.1 CD34 HGF
19 spindle cell liposarcoma 10.1 CD34 MLANA
20 limb ischemia 10.0 EDN1 HGF
21 skin melanoma 10.0 PMEL TYR
22 melanomatosis 10.0 CD68 CWC22
23 halo nevi 10.0 MLANA PMEL TYR
24 melanoacanthoma 10.0 MLANA PMEL TYR
25 obstructive jaundice 10.0 EDN1 HGF
26 melanoma, uveal 10.0 MLANA PMEL TYR
27 retina lymphoma 9.9 CD34 CD68
28 balloon cell malignant melanoma 9.9 CD68 MLANA
29 extracutaneous mastocytoma 9.9 CD34 CD68
30 sternum cancer 9.9 CD34 CD68
31 brain sarcoma 9.9 CD68 MLANA
32 glomeruloid hemangioma 9.9 CD34 CD68
33 hemangioma of liver 9.9 CD34 CD68
34 spleen cancer 9.9 CD34 CD68
35 melanoma 9.9
36 conventional fibrosarcoma 9.9 CD34 CD68
37 mixed liposarcoma 9.9 CD34 CD68
38 breast angiosarcoma 9.9 CD34 MLANA TYR
39 ischemic fasciitis 9.9 CD34 CD68
40 myxosarcoma 9.9 CD68 MLANA
41 microphthalmia 9.9 MLANA PMEL TYR
42 aleukemic leukemia cutis 9.9 CD34 CD68
43 nodular tenosynovitis 9.9 CD68 S100A9
44 hemangioma of intra-abdominal structure 9.9 CD34 CD68
45 hemopericardium 9.8
46 pericardial effusion 9.8
47 skin sarcoma 9.8 CD34 CD68
48 idiopathic interstitial pneumonia 9.8 CD34 EDN1
49 optic nerve disease 9.8 EDN1 TYR
50 connective tissue cancer 9.8 CD34 CD68

Graphical network of the top 20 diseases related to Diffuse Meningeal Melanocytosis:



Diseases related to Diffuse Meningeal Melanocytosis

Symptoms & Phenotypes for Diffuse Meningeal Melanocytosis

UMLS symptoms related to Diffuse Meningeal Melanocytosis:


seizures

MGI Mouse Phenotypes related to Diffuse Meningeal Melanocytosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.02 CD68 HGF MLANA PMEL TYR

Drugs & Therapeutics for Diffuse Meningeal Melanocytosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Identification of Compound Isolated From Cock's Comb and Its Effect on Arsenical Palmar Keratosis Recruiting NCT03635853 Phase 2 drug containing extract from cock's comb

Search NIH Clinical Center for Diffuse Meningeal Melanocytosis

Genetic Tests for Diffuse Meningeal Melanocytosis

Anatomical Context for Diffuse Meningeal Melanocytosis

MalaCards organs/tissues related to Diffuse Meningeal Melanocytosis:

42
Brain

Publications for Diffuse Meningeal Melanocytosis

Articles related to Diffuse Meningeal Melanocytosis:

# Title Authors Year
1
Black brain: transformation of a melanocytoma with diffuse melanocytosis into a primary cerebral melanoma. ( 20640479 )
2011

Variations for Diffuse Meningeal Melanocytosis

Expression for Diffuse Meningeal Melanocytosis

Search GEO for disease gene expression data for Diffuse Meningeal Melanocytosis.

Pathways for Diffuse Meningeal Melanocytosis

Pathways related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.42 EDN1 HGF

GO Terms for Diffuse Meningeal Melanocytosis

Cellular components related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome GO:0042470 8.8 MLANA PMEL TYR

Biological processes related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 9.32 CD34 EDN1
2 positive regulation of interleukin-10 production GO:0032733 9.26 CD34 HGF
3 negative regulation of blood coagulation GO:0030195 9.16 CD34 EDN1
4 melanin biosynthetic process GO:0042438 8.96 PMEL TYR
5 positive regulation of odontogenesis GO:0042482 8.62 CD34 EDN1

Sources for Diffuse Meningeal Melanocytosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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