MCID: DFF013
MIFTS: 22

Diffuse Meningeal Melanocytosis

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Diffuse Meningeal Melanocytosis

MalaCards integrated aliases for Diffuse Meningeal Melanocytosis:

Name: Diffuse Meningeal Melanocytosis 12 15
Diffuse Melanocytosis 12 17 71
Diffuse Melanosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6379
NCIt 49 C6890
UMLS 71 C1266112

Summaries for Diffuse Meningeal Melanocytosis

MalaCards based summary : Diffuse Meningeal Melanocytosis, also known as diffuse melanocytosis, is related to nodular malignant melanoma and dowling-degos disease 1, and has symptoms including seizures An important gene associated with Diffuse Meningeal Melanocytosis is MLANA (Melan-A), and among its related pathways/superpathways is Tyrosine metabolism. Affiliated tissues include kidney, skin and brain, and related phenotype is no phenotypic analysis.

Related Diseases for Diffuse Meningeal Melanocytosis

Diseases related to Diffuse Meningeal Melanocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 nodular malignant melanoma 29.9 TYR MLANA
2 dowling-degos disease 1 29.9 TYR POMC
3 skin melanoma 29.4 TYR MLANA
4 melanoma 10.4
5 meningeal melanocytoma 10.2 MLANA MIB1
6 central nervous system melanocytic neoplasm 10.2 MLANA MIB1
7 malignant ciliary body melanoma 10.1 TYR MLANA
8 ciliary body cancer 10.1 TYR MLANA
9 halo nevi 10.1 TYR MLANA
10 melanoacanthoma 10.1 TYR MLANA
11 sarcomatoid transitional cell carcinoma 10.1 TYR MLANA
12 epithelioid cell melanoma 10.1 TYR MLANA
13 mixed cell uveal melanoma 10.1 TYR MLANA
14 malignant spindle cell melanoma 10.1 TYR MLANA
15 amelanotic melanoma 10.1 TYR MLANA
16 melanotic neurilemmoma 10.0 POMC MLANA
17 olfactory nerve neoplasm 10.0 POMC MLANA
18 cranial nerve malignant neoplasm 10.0 POMC MLANA
19 cranial nerve neoplasm 10.0 POMC MLANA
20 testicular sex cord-stromal neoplasm 10.0 POMC MLANA
21 angiomyolipoma 10.0 TYR MLANA
22 sex cord-gonadal stromal tumor 10.0 POMC MLANA
23 ocular albinism 10.0 TYR MLANA
24 adrenal cortical carcinoma 10.0 POMC MLANA
25 carney complex variant 9.9 POMC MLANA
26 adrenal cortical adenoma 9.9 POMC MLANA
27 colorectal cancer 9.9
28 hemopericardium 9.9
29 pericardial effusion 9.9
30 vulvar melanoma 9.9
31 neurilemmoma 9.9
32 acral lentiginous melanoma 9.9
33 placenta disease 9.9
34 48,xyyy 9.9
35 adrenal carcinoma 9.8 POMC MLANA
36 drug dependence 9.7 POMC ADH1B
37 acute kidney tubular necrosis 9.7 TYR HGF
38 vitiligo-associated multiple autoimmune disease susceptibility 1 9.7 TYR POMC MLANA
39 acute kidney failure 9.6 TYR HGF
40 skin carcinoma 9.6 TYR POMC MLANA
41 alcoholic liver cirrhosis 9.6 HGF ADH1B
42 spinal cord melanoma 9.5 TYR MLANA HGF
43 neurofibroma 9.5 TYR MLANA HGF
44 melanoma, uveal 9.5 TYR MLANA HGF
45 waardenburg's syndrome 9.4 TYR POMC
46 microphthalmia 9.4 TYR POMC MLANA

Graphical network of the top 20 diseases related to Diffuse Meningeal Melanocytosis:



Diseases related to Diffuse Meningeal Melanocytosis

Symptoms & Phenotypes for Diffuse Meningeal Melanocytosis

UMLS symptoms related to Diffuse Meningeal Melanocytosis:


seizures

MGI Mouse Phenotypes related to Diffuse Meningeal Melanocytosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.02 HGF MIB1 MLANA POMC TYR

Drugs & Therapeutics for Diffuse Meningeal Melanocytosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Identification of Compound Isolated From Cock's Comb and Its Effect on Arsenical Palmar Keratosis Recruiting NCT03635853 Phase 2 drug containing extract from cock's comb

Search NIH Clinical Center for Diffuse Meningeal Melanocytosis

Genetic Tests for Diffuse Meningeal Melanocytosis

Anatomical Context for Diffuse Meningeal Melanocytosis

MalaCards organs/tissues related to Diffuse Meningeal Melanocytosis:

40
Kidney, Skin, Brain, Spinal Cord, Liver, Placenta

Publications for Diffuse Meningeal Melanocytosis

Articles related to Diffuse Meningeal Melanocytosis:

# Title Authors PMID Year
1
Neurocutaneous Melanosis in an Adult Patient with Intracranial Primary Malignant Melanoma: Case Report and Review of the Literature. 61
29530698 2018
2
An uncommon mimic of spontaneous subarachnoid haemorrhage. 61
23378361 2013
3
Primary melanocytic tumors of the central nervous system: a neuroradiological and clinicopathological study of five cases and brief review of literature. 61
21743173 2011
4
Black brain: transformation of a melanocytoma with diffuse melanocytosis into a primary cerebral melanoma. 61
20640479 2011
5
Pigmented lesions of the central nervous system: radiologic-pathologic correlation. 61
19755608 2009
6
Progressive brainstem compression in an infant with neurocutaneous melanosis and Dandy-Walker complex following ventriculoperitoneal shunt placement for hydrocephalus. Case report. 61
18154021 2007
7
Primary melanocytic lesions of the CNS: report of five cases. 61
15306980 2004
8
Glaucoma in phakomatosis pigmentovascularis. 61
9022120 1997

Variations for Diffuse Meningeal Melanocytosis

Expression for Diffuse Meningeal Melanocytosis

Search GEO for disease gene expression data for Diffuse Meningeal Melanocytosis.

Pathways for Diffuse Meningeal Melanocytosis

Pathways related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.5 TYR ADH1B

GO Terms for Diffuse Meningeal Melanocytosis

Cellular components related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome GO:0042470 8.62 TYR MLANA

Sources for Diffuse Meningeal Melanocytosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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