Diffuse Meningeal Melanocytosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Diffuse Meningeal Melanocytosis

MalaCards integrated aliases for Diffuse Meningeal Melanocytosis:

Name: Diffuse Meningeal Melanocytosis ¹² ¹⁵

Diffuse Melanocytosis ¹² ⁷³

Diffuse Melanosis ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6379

NCIt ⁵⁰ C6890

UMLS ⁷³ C1266112

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Summaries for Diffuse Meningeal Melanocytosis

MalaCards based summary : Diffuse Meningeal Melanocytosis, also known as diffuse melanocytosis, is related to vulvar melanoma and malignant spindle cell melanoma, and has symptoms including seizures An important gene associated with Diffuse Meningeal Melanocytosis is ZIC1 (Zic Family Member 1), and among its related pathways/superpathways is Lung fibrosis. Affiliated tissues include brain, skin and kidney, and related phenotype is no phenotypic analysis.

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Related Diseases for Diffuse Meningeal Melanocytosis

Diseases related to Diffuse Meningeal Melanocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)

#	Related Disease	Score	Top Affiliating Genes
1	vulvar melanoma	29.8	MLANA TYR
2	malignant spindle cell melanoma	10.1	PMEL TYR
3	vitiligo-associated multiple autoimmune disease susceptibility 6	10.1	PMEL TYR
4	melanomatosis	10.1	CD68 CWC22
5	hermansky-pudlak syndrome 3	10.1	PMEL TYR
6	gallbladder melanoma	10.1	MLANA PMEL
7	low tension glaucoma	10.1	EDN1 OPTN
8	melanocytic nevus syndrome, congenital	10.1	EDN1 TYR
9	acute kidney tubular necrosis	10.1	HGF TYR
10	vitiligo-associated multiple autoimmune disease susceptibility 1	10.1	PMEL TYR
11	dowling-degos disease 1	10.1	EDN1 TYR
12	pigmented basal cell carcinoma	10.0	MLANA TYR
13	epithelioid cell melanoma	10.0	MLANA TYR
14	breast angiosarcoma	10.0	MLANA TYR
15	balloon cell malignant melanoma	10.0	CD68 MLANA
16	malignant skin fibrous histiocytoma	10.0	MLANA TYR
17	acute kidney failure	10.0	HGF TYR
18	vogt-koyanagi-harada disease	10.0	PMEL TYR
19	brain sarcoma	10.0	CD68 MLANA
20	malignant dermis tumor	10.0	MLANA TYR
21	myxosarcoma	10.0	CD68 MLANA
22	sarcomatoid squamous cell skin carcinoma	10.0	CD68 MLANA
23	optic nerve disease	10.0	EDN1 OPTN TYR
24	limb ischemia	10.0	EDN1 HGF
25	nodular tenosynovitis	9.9	CD68 S100A9
26	halo nevi	9.9	MLANA PMEL TYR
27	adult xanthogranuloma	9.9	CD68 S100A9
28	melanoacanthoma	9.9	MLANA PMEL TYR
29	melanoma, uveal	9.9	MLANA PMEL TYR
30	erythema elevatum diutinum	9.9	CD68 S100A9
31	meningeal melanocytoma	9.9	CD68 CWC22 MLANA
32	reticulohistiocytic granuloma	9.9	CD68 S100A9
33	skin melanoma	9.9	PMEL TYR
34	melanoma	9.9
35	obstructive jaundice	9.9	EDN1 HGF
36	congenital epulis	9.9	CD68 S100A9
37	xanthogranulomatous cholecystitis	9.9	CD68 S100A9
38	microphthalmia	9.8	MLANA PMEL TYR
39	central nervous system melanocytic neoplasm	8.9	CD68 CWC22 HGF MLANA OPTN PMEL

Graphical network of the top 20 diseases related to Diffuse Meningeal Melanocytosis:

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Symptoms & Phenotypes for Diffuse Meningeal Melanocytosis

UMLS symptoms related to Diffuse Meningeal Melanocytosis:

seizures

MGI Mouse Phenotypes related to Diffuse Meningeal Melanocytosis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	no phenotypic analysis	MP:0003012	9.1	CD68 HGF MLANA OPTN PMEL TYR

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Drugs & Therapeutics for Diffuse Meningeal Melanocytosis

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Identification of Compound Isolated From Cock's Comb and Its Effect on Arsenical Palmar Keratosis	Recruiting	NCT03635853	Phase 2	drug containing extract from cock's comb

Search NIH Clinical Center for Diffuse Meningeal Melanocytosis

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Genetic Tests for Diffuse Meningeal Melanocytosis

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Anatomical Context for Diffuse Meningeal Melanocytosis

MalaCards organs/tissues related to Diffuse Meningeal Melanocytosis:

⁴¹

Brain, Skin, Kidney, Breast

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Publications for Diffuse Meningeal Melanocytosis

Articles related to Diffuse Meningeal Melanocytosis:

#	Title	Authors	Year
1	Black brain: transformation of a melanocytoma with diffuse melanocytosis into a primary cerebral melanoma. ( 20640479 )	Gempt J...Ringel F	2011

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Genes for Diffuse Meningeal Melanocytosis

Genes related to Diffuse Meningeal Melanocytosis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ZIC1	Zic Family Member 1	Protein Coding	15.67	DISEASES inferred ¹⁵
2	CWC22	CWC22 Spliceosome Associated Protein Homolog	Protein Coding	15.36	DISEASES inferred ¹⁵
3	PMEL	Premelanosome Protein	Protein Coding	14.62	DISEASES inferred ¹⁵
4	OPTN	Optineurin	Protein Coding	14.29	DISEASES inferred ¹⁵
5	TYR	Tyrosinase	Protein Coding	14.28	DISEASES inferred ¹⁵
6	HGF	Hepatocyte Growth Factor	Protein Coding	13.82	DISEASES inferred ¹⁵
7	EDN1	Endothelin 1	Protein Coding	13.36	DISEASES inferred ¹⁵
8	MLANA	Melan-A	Protein Coding	5.19	DISEASES inferred ¹⁵
9	S100A9	S100 Calcium Binding Protein A9	Protein Coding	4.73	DISEASES inferred ¹⁵
10	CD68	CD68 Molecule	Protein Coding	4.38	DISEASES inferred ¹⁵

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Variations for Diffuse Meningeal Melanocytosis

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Expression for Diffuse Meningeal Melanocytosis

Search GEO for disease gene expression data for Diffuse Meningeal Melanocytosis.

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Pathways for Diffuse Meningeal Melanocytosis

Pathways related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Lung fibrosis ¹	10.42	EDN1 HGF

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GO Terms for Diffuse Meningeal Melanocytosis

Cellular components related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	melanosome	GO:0042470	8.8	MLANA PMEL TYR

Biological processes related to Diffuse Meningeal Melanocytosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	melanin biosynthetic process	GO:0042438	8.62	PMEL TYR

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Sources for Diffuse Meningeal Melanocytosis

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