MCID: DFF021
MIFTS: 36

Diffuse Mesangial Sclerosis

Categories: Rare diseases, Nephrological diseases, Genetic diseases

Aliases & Classifications for Diffuse Mesangial Sclerosis

MalaCards integrated aliases for Diffuse Mesangial Sclerosis:

Name: Diffuse Mesangial Sclerosis 53 29 6 73
Familial Mesangial Sclerosis 53 73
Mesangial Sclerosis, Diffuse 53 55
Nephrotic Syndrome, Early Onset with Diffuse Mesangial Sclerosis 53
Diffuse Isolated Mesangial Sclerosis 53
Isolated Diffuse Mesangial Sclerosis 53
Dms 53

Classifications:



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Summaries for Diffuse Mesangial Sclerosis

MalaCards based summary : Diffuse Mesangial Sclerosis, also known as familial mesangial sclerosis, is related to sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis and familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis. An important gene associated with Diffuse Mesangial Sclerosis is WT1 (Wilms Tumor 1), and among its related pathways/superpathways are Phospholipase-C Pathway and Pathways in cancer. Affiliated tissues include brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Diffuse Mesangial Sclerosis

Diseases related to Diffuse Mesangial Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis 34.3 PLCE1 WT1
2 familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis 33.1 ARHGDIA NPHS1 PLCE1 WT1
3 pierson syndrome 31.4 LAMB1 LAMB2 NPHS2
4 denys-drash syndrome 30.2 NPHS1 NPHS2 PAX2 PDGFA WT1
5 nephrotic syndrome 28.4 ARHGDIA LAMB2 NPHS1 NPHS2 PLCE1 WT1
6 mesangial sclerosis, diffuse renal, with ocular abnormalities 12.2
7 nephrotic syndrome, type 4 12.0
8 myotonic dystrophy 1 11.8
9 epidermolysis bullosa simplex, dowling-meara type 11.7
10 nephrotic syndrome, type 3 11.4
11 maturity-onset diabetes of the young 11.3
12 diabetes insipidus 11.3
13 diabetes mellitus 11.2
14 childhood type dermatomyositis 11.2
15 neonatal dermatomyositis 11.2
16 dermatomyositis 11.1
17 nephrotic syndrome, type 8 11.1
18 diaphyseal medullary stenosis with malignant fibrous histiocytoma 10.9
19 myotonic dystrophy 2 10.8
20 wolfram syndrome 10.8
21 meacham syndrome 10.5 WT1 WT1-AS
22 renal adenoma 10.3 PAX2 WT1
23 mayer-rokitansky-kuster-hauser syndrome 10.2 LAMC1 PAX2 WT1
24 microcephaly 10.0
25 wilms tumor 5 9.8
26 kawasaki disease 9.8
27 wilms tumor 6 9.8
28 cataract 9.8
29 coenzyme q10 deficiency disease 9.8
30 dyskeratosis congenita 9.8
31 familial idiopathic steroid-resistant nephrotic syndrome with minimal changes 9.6 NPHS1 NPHS2
32 nephrotic syndrome, type 1 9.4 NPHS1 NPHS2 WT1
33 hypoparathyroidism, sensorineural deafness, and renal disease 9.4 LAMB2 NPHS1 NPHS2
34 galloway-mowat syndrome 9.3 LAMB2 NPHS1 NPHS2
35 kidney hypertrophy 9.2 NPHS1 NPHS2 TGFB1
36 familial nephrotic syndrome 9.2 NPHS1 NPHS2 PLCE1 WT1
37 urinary system disease 9.1 NPHS1 NPHS2 TGFB1
38 iga glomerulonephritis 9.0 NPHS1 NPHS2 TGFB1
39 membranous nephropathy 9.0 NPHS1 NPHS2 TGFB1
40 atrial septal defect 3 9.0 NPHS1 NPHS2
41 wilms tumor 1 8.9 KRBOX4 NPHS2 PAX2 WT1 WT1-AS
42 focal segmental glomerulosclerosis 1 8.8 NPHS1 NPHS2 PAX2 PLCE1 WT1
43 glomerulonephritis 8.7 NPHS1 NPHS2 TGFB1
44 end stage renal failure 8.7 NPHS1 NPHS2 PLCE1 TGFB1 WT1
45 chronic kidney failure 8.6 NPHS1 NPHS2 PAX2 TGFB1 WT1
46 kidney disease 8.5 NPHS1 NPHS2 PAX2 TGFB1 WT1
47 frasier syndrome 8.3 NPHS1 NPHS2 PDGFA PLCE1 WT1 WT1-AS
48 focal segmental glomerulosclerosis 8.0 LAMB2 NPHS1 NPHS2 PAX2 PLCE1 TGFB1

Graphical network of the top 20 diseases related to Diffuse Mesangial Sclerosis:



Diseases related to Diffuse Mesangial Sclerosis

Symptoms & Phenotypes for Diffuse Mesangial Sclerosis

MGI Mouse Phenotypes related to Diffuse Mesangial Sclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 NPHS2 PAX2 AGRN PDGFA PLCE1 ARHGDIA
2 homeostasis/metabolism MP:0005376 9.96 WT1 LAMC1 NPHS1 NPHS2 AGRN PDGFA
3 mortality/aging MP:0010768 9.9 WT1 LAMC1 NPHS1 NPHS2 PAX2 AGRN
4 muscle MP:0005369 9.5 LAMC1 AGRN PDGFA PLCE1 LAMB1 TGFB1
5 renal/urinary system MP:0005367 9.32 NPHS1 NPHS2 PAX2 AGRN PDGFA ARHGDIA

Drugs & Therapeutics for Diffuse Mesangial Sclerosis

Search Clinical Trials , NIH Clinical Center for Diffuse Mesangial Sclerosis

Genetic Tests for Diffuse Mesangial Sclerosis

Genetic tests related to Diffuse Mesangial Sclerosis:

# Genetic test Affiliating Genes
1 Diffuse Mesangial Sclerosis 29 WT1

Anatomical Context for Diffuse Mesangial Sclerosis

MalaCards organs/tissues related to Diffuse Mesangial Sclerosis:

41
Brain

Publications for Diffuse Mesangial Sclerosis

Articles related to Diffuse Mesangial Sclerosis:

(show all 39)
# Title Authors Year
1
Diffuse mesangial sclerosis in a PDSS2 mutation-induced coenzyme Q10 deficiency. ( 29032433 )
2018
2
Diffuse Mesangial Sclerosis in a Child With Dyskeratosis Congenita Leading to End-stage Renal Disease. ( 27904002 )
2016
3
AJKD Atlas of Renal Pathology: Diffuse Mesangial Sclerosis. ( 26408240 )
2015
4
Glomerular epithelial cell phenotype in diffuse mesangial sclerosis: a report of 2 cases with markedly increased urinary podocyte excretion. ( 24856573 )
2014
5
Diffuse mesangial sclerosis - Report of two cases. ( 23087559 )
2012
6
Respiratory-chain deficiency presenting as diffuse mesangial sclerosis with NPHS3 mutation. ( 21365190 )
2011
7
Mutations in phospholipase C epsilon 1 are not sufficient to cause diffuse mesangial sclerosis. ( 19037252 )
2009
8
Evolutive study of children with diffuse mesangial sclerosis. ( 19066977 )
2009
9
Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS). ( 18065803 )
2008
10
Two cases of isolated diffuse mesangial sclerosis with WT1 mutations. ( 16479084 )
2006
11
Cytomegalovirus-related congenital nephrotic syndrome with diffuse mesangial sclerosis. ( 16523262 )
2006
12
Congenital nephrotic syndrome: report of an infant with diffuse mesangial sclerosis. ( 14964988 )
2003
13
Diffuse mesangial sclerosis presenting as infantile nephrotic syndrome. ( 11418734 )
2001
14
Glomerular extracellular matrix and growth factors in diffuse mesangial sclerosis. ( 11405118 )
2001
15
Isolated diffuse mesangial sclerosis and Wilms tumor suppressor gene. ( 11241056 )
2001
16
Immunohistochemical analysis of molecular events in tubulo-interstitial fibrosis in a mouse model of diffuse mesangial sclerosis (ICGN strain). ( 11307931 )
2001
17
Absence of correlation between genotype and the severity of diffuse mesangial sclerosis in Denys-Drash syndrome. ( 10805477 )
2000
18
WT1 and PAX-2 podocyte expression in Denys-Drash syndrome and isolated diffuse mesangial sclerosis. ( 9916932 )
1999
19
Nephrotic mice (ICGN strain): a model of diffuse mesangial sclerosis in infantile nephrotic syndrome. ( 10085455 )
1999
20
Identification of constitutional WT1 mutations, in patients with isolated diffuse mesangial sclerosis, and analysis of genotype/phenotype correlations by use of a computerized mutation database. ( 9529364 )
1998
21
Isolated diffuse mesangial sclerosis in three siblings. ( 9546709 )
1998
22
Diffuse mesangial sclerosis: association with unreported congenital anomalies and placental enlargement. ( 9894834 )
1998
23
Diffuse mesangial sclerosis associated with Kawasaki disease: an analysis of alpha chains (alpha 1-alpha 6) of human type IV collagen in the renal basement membrane. ( 9230914 )
1997
24
Hypoplastic tubules occurring in diffuse mesangial sclerosis. ( 8970202 )
1996
25
Congenital nephrotic syndrome, diffuse mesangial sclerosis, and bilateral cataract. ( 8971891 )
1996
26
Diffuse mesangial sclerosis: a unique type of congenital and infantile nephrotic syndrome. ( 8684541 )
1996
27
Do children with diffuse mesangial sclerosis in association with mutations of the Wilm's tumour suppressor gene (WT1) require bilateral nephrectomy? ( 7794729 )
1995
28
Microcephaly and congenital nephrotic syndrome owing to diffuse mesangial sclerosis: an autosomal recessive syndrome. ( 8182716 )
1994
29
Diffuse mesangial sclerosis: a congenital glomerulopathy with nephrotic syndrome. ( 8381254 )
1993
30
Should bilateral nephrectomy be carried out in all children with diffuse mesangial sclerosis prior to renal transplantation in view of the connection with Drash syndrome and therefore the risk of a Wilms' tumour developing? ( 1319726 )
1992
31
Diffuse mesangial sclerosis in a fetus. ( 1889151 )
1991
32
Clinical quiz. Congenital nephrotic syndrome, microcephaly, brain malformations and diaphragmatic abnormality associated with histological features of diffuse mesangial sclerosis. ( 1911117 )
1991
33
Congenital/infantile nephrotic syndrome with diffuse mesangial sclerosis: relationship with Drash syndrome. ( 2762352 )
1989
34
Clinicopathological quiz. Wilms' tumour with renal failure due to diffuse mesangial sclerosis. ( 2856390 )
1987
35
Diffuse mesangial sclerosis--light, immunofluorescent and electronmicroscopy findings. ( 3897087 )
1985
36
Nephrotic syndrome with diffuse mesangial sclerosis in identical twins. ( 6682143 )
1983
37
Familial early-onset nephrotic syndrome: diffuse mesangial sclerosis. Clinico-pathological study of a kindred. ( 7180443 )
1982
38
Diffuse mesangial sclerosis and ocular abnormalities in two siblings. ( 6809680 )
1982
39
Infantile nephrotic syndrome with diffuse mesangial sclerosis: a disturbance of glomerular basement membrane development? ( 7379364 )
1980

Variations for Diffuse Mesangial Sclerosis

ClinVar genetic disease variations for Diffuse Mesangial Sclerosis:

6
(show top 50) (show all 194)
# Gene Variation Type Significance SNP ID Assembly Location
1 WT1 NM_024426.4(WT1): c.1384C> T (p.Arg462Trp) single nucleotide variant Pathogenic rs121907900 GRCh37 Chromosome 11, 32413566: 32413566
2 WT1 NM_024426.4(WT1): c.1384C> T (p.Arg462Trp) single nucleotide variant Pathogenic rs121907900 GRCh38 Chromosome 11, 32392020: 32392020
3 WT1 NM_024426.4(WT1): c.1390G> A (p.Asp464Asn) single nucleotide variant Pathogenic rs28941778 GRCh37 Chromosome 11, 32413560: 32413560
4 WT1 NM_024426.4(WT1): c.1390G> A (p.Asp464Asn) single nucleotide variant Pathogenic rs28941778 GRCh38 Chromosome 11, 32392014: 32392014
5 WT1 NM_024426.5(WT1): c.1447+5G> A single nucleotide variant Pathogenic rs587776576 GRCh38 Chromosome 11, 32391967: 32391967
6 WT1 NM_024426.5(WT1): c.1447+5G> A single nucleotide variant Pathogenic rs587776576 GRCh37 Chromosome 11, 32413513: 32413513
7 WT1 NM_024426.4(WT1): c.1333C> T (p.His445Tyr) single nucleotide variant Pathogenic rs28942089 GRCh37 Chromosome 11, 32414218: 32414218
8 WT1 NM_024426.4(WT1): c.1333C> T (p.His445Tyr) single nucleotide variant Pathogenic rs28942089 GRCh38 Chromosome 11, 32392672: 32392672
9 WT1 NM_024426.4(WT1): c.1432+4C> T single nucleotide variant Pathogenic rs587776577 GRCh38 Chromosome 11, 32391968: 32391968
10 WT1 NM_024426.4(WT1): c.1432+4C> T single nucleotide variant Pathogenic rs587776577 GRCh37 Chromosome 11, 32413514: 32413514
11 WT1 NM_024426.4(WT1): c.1351T> C (p.Phe451Leu) single nucleotide variant Pathogenic rs28941777 GRCh37 Chromosome 11, 32413599: 32413599
12 WT1 NM_024426.4(WT1): c.1351T> C (p.Phe451Leu) single nucleotide variant Pathogenic rs28941777 GRCh38 Chromosome 11, 32392053: 32392053
13 WT1 NM_024426.4(WT1): c.108G> C (p.Pro36=) single nucleotide variant Conflicting interpretations of pathogenicity rs555140661 GRCh37 Chromosome 11, 32456784: 32456784
14 WT1 NM_024426.4(WT1): c.108G> C (p.Pro36=) single nucleotide variant Conflicting interpretations of pathogenicity rs555140661 GRCh38 Chromosome 11, 32435238: 32435238
15 WT1 NM_024426.4(WT1): c.330C> T (p.Pro110=) single nucleotide variant Benign rs1799925 GRCh37 Chromosome 11, 32456562: 32456562
16 WT1 NM_024426.4(WT1): c.330C> T (p.Pro110=) single nucleotide variant Benign rs1799925 GRCh38 Chromosome 11, 32435016: 32435016
17 WT1 NM_024426.4(WT1): c.1107A> G (p.Arg369=) single nucleotide variant Benign rs16754 GRCh37 Chromosome 11, 32417945: 32417945
18 WT1 NM_024426.4(WT1): c.1107A> G (p.Arg369=) single nucleotide variant Benign rs16754 GRCh38 Chromosome 11, 32396399: 32396399
19 WT1 NM_024426.4(WT1): c.1099-9T> C single nucleotide variant Benign/Likely benign rs5030274 GRCh38 Chromosome 11, 32396416: 32396416
20 WT1 NM_024426.4(WT1): c.1099-9T> C single nucleotide variant Benign/Likely benign rs5030274 GRCh37 Chromosome 11, 32417962: 32417962
21 WT1 NM_024426.4(WT1): c.360C> T (p.Gly120=) single nucleotide variant Conflicting interpretations of pathogenicity rs776209354 GRCh38 Chromosome 11, 32434986: 32434986
22 WT1 NM_024426.4(WT1): c.360C> T (p.Gly120=) single nucleotide variant Conflicting interpretations of pathogenicity rs776209354 GRCh37 Chromosome 11, 32456532: 32456532
23 WT1 NM_024426.4(WT1): c.294C> A (p.Gly98=) single nucleotide variant Benign/Likely benign rs547333427 GRCh38 Chromosome 11, 32435052: 32435052
24 WT1 NM_024426.4(WT1): c.294C> A (p.Gly98=) single nucleotide variant Benign/Likely benign rs547333427 GRCh37 Chromosome 11, 32456598: 32456598
25 WT1 NM_024426.4(WT1): c.201G> T (p.Gln67His) single nucleotide variant Benign/Likely benign rs5030135 GRCh38 Chromosome 11, 32435145: 32435145
26 WT1 NM_024426.4(WT1): c.201G> T (p.Gln67His) single nucleotide variant Benign/Likely benign rs5030135 GRCh37 Chromosome 11, 32456691: 32456691
27 WT1 NM_024426.4(WT1): c.166C> A (p.Arg56=) single nucleotide variant Benign/Likely benign rs2234581 GRCh38 Chromosome 11, 32435180: 32435180
28 WT1 NM_024426.4(WT1): c.166C> A (p.Arg56=) single nucleotide variant Benign/Likely benign rs2234581 GRCh37 Chromosome 11, 32456726: 32456726
29 WT1 NM_024426.4(WT1): c.68G> A (p.Gly23Glu) single nucleotide variant Uncertain significance rs751641518 GRCh38 Chromosome 11, 32435278: 32435278
30 WT1 NM_024426.4(WT1): c.68G> A (p.Gly23Glu) single nucleotide variant Uncertain significance rs751641518 GRCh37 Chromosome 11, 32456824: 32456824
31 WT1 NM_024426.4(WT1): c.1059A> G (p.Gln353=) single nucleotide variant Benign/Likely benign rs2234590 GRCh37 Chromosome 11, 32421533: 32421533
32 WT1 NM_024426.4(WT1): c.1059A> G (p.Gln353=) single nucleotide variant Benign/Likely benign rs2234590 GRCh38 Chromosome 11, 32399987: 32399987
33 WT1 NM_024426.4(WT1): c.681C> T (p.Ser227=) single nucleotide variant Benign/Likely benign rs9332974 GRCh38 Chromosome 11, 32428585: 32428585
34 WT1 NM_024426.4(WT1): c.681C> T (p.Ser227=) single nucleotide variant Benign/Likely benign rs9332974 GRCh37 Chromosome 11, 32450131: 32450131
35 WT1 NM_024426.4(WT1): c.594C> T (p.Asn198=) single nucleotide variant Benign/Likely benign rs2234583 GRCh37 Chromosome 11, 32456298: 32456298
36 WT1 NM_024426.4(WT1): c.594C> T (p.Asn198=) single nucleotide variant Benign/Likely benign rs2234583 GRCh38 Chromosome 11, 32434752: 32434752
37 WT1 NM_024426.4(WT1): c.498C> A (p.Gly166=) single nucleotide variant Benign/Likely benign rs536728682 GRCh38 Chromosome 11, 32434848: 32434848
38 WT1 NM_024426.4(WT1): c.498C> A (p.Gly166=) single nucleotide variant Benign/Likely benign rs536728682 GRCh37 Chromosome 11, 32456394: 32456394
39 WT1 NM_024426.4(WT1): c.366C> G (p.Pro122=) single nucleotide variant Conflicting interpretations of pathogenicity rs771681406 GRCh38 Chromosome 11, 32434980: 32434980
40 WT1 NM_024426.4(WT1): c.366C> G (p.Pro122=) single nucleotide variant Conflicting interpretations of pathogenicity rs771681406 GRCh37 Chromosome 11, 32456526: 32456526
41 WT1 NM_024426.4(WT1): c.198G> T (p.Pro66=) single nucleotide variant Benign rs2234582 GRCh37 Chromosome 11, 32456694: 32456694
42 WT1 NM_024426.4(WT1): c.198G> T (p.Pro66=) single nucleotide variant Benign rs2234582 GRCh38 Chromosome 11, 32435148: 32435148
43 WT1 NM_024426.4(WT1): c.*1132A> T single nucleotide variant Likely benign rs5030328 GRCh38 Chromosome 11, 32387926: 32387926
44 WT1 NM_024426.4(WT1): c.*1132A> T single nucleotide variant Likely benign rs5030328 GRCh37 Chromosome 11, 32409472: 32409472
45 WT1 NM_024426.4(WT1): c.*1098C> T single nucleotide variant Likely benign rs5030327 GRCh38 Chromosome 11, 32387960: 32387960
46 WT1 NM_024426.4(WT1): c.*1098C> T single nucleotide variant Likely benign rs5030327 GRCh37 Chromosome 11, 32409506: 32409506
47 WT1 NM_024426.4(WT1): c.*1058G> T single nucleotide variant Uncertain significance rs886048211 GRCh37 Chromosome 11, 32409546: 32409546
48 WT1 NM_024426.4(WT1): c.*1058G> T single nucleotide variant Uncertain significance rs886048211 GRCh38 Chromosome 11, 32388000: 32388000
49 WT1 NM_024426.4(WT1): c.*1053_*1054dupGT duplication Uncertain significance rs878917290 GRCh37 Chromosome 11, 32409550: 32409551
50 WT1 NM_024426.4(WT1): c.*1053_*1054dupGT duplication Uncertain significance rs878917290 GRCh38 Chromosome 11, 32388004: 32388005

Expression for Diffuse Mesangial Sclerosis

Search GEO for disease gene expression data for Diffuse Mesangial Sclerosis.

Pathways for Diffuse Mesangial Sclerosis

Pathways related to Diffuse Mesangial Sclerosis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.82 LAMB1 LAMB2 LAMC1 PDGFA PLCE1 TGFB1
2 12.61 LAMB1 LAMB2 LAMC1 PDGFA TGFB1
3
Show member pathways
12.39 AGRN LAMB1 LAMB2 LAMC1 PDGFA TGFB1
4
Show member pathways
12.05 LAMB1 LAMB2 LAMC1 TGFB1
5
Show member pathways
11.88 AGRN LAMB1 LAMB2 LAMC1
6
Show member pathways
11.86 AGRN LAMB2 LAMC1
7 11.82 PAX2 TGFB1 WT1
8 11.65 LAMB1 LAMB2 LAMC1
9 11.6 LAMB1 LAMB2 LAMC1 TGFB1
10 11.31 AGRN LAMB1 LAMB2 LAMC1 TGFB1
11 11.3 LAMB1 LAMC1 TGFB1
12
Show member pathways
11.26 AGRN LAMB1 LAMB2 LAMC1 PDGFA TGFB1
13 11.09 AGRN LAMB2 NPHS1 NPHS2 PAX2 PLCE1
14 11.06 LAMB1 LAMB2 LAMC1
15 11.03 PDGFA TGFB1
16 10.96 NPHS1 NPHS2

GO Terms for Diffuse Mesangial Sclerosis

Cellular components related to Diffuse Mesangial Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.71 LAMB1 LAMB2 LAMC1 PDGFA
2 Golgi lumen GO:0005796 9.61 AGRN PDGFA TGFB1
3 basement membrane GO:0005604 9.54 LAMB1 LAMB2 LAMC1
4 basal lamina GO:0005605 9.46 AGRN LAMB2
5 slit diaphragm GO:0036057 9.32 NPHS1 NPHS2
6 laminin-1 complex GO:0005606 9.26 LAMB1 LAMC1
7 laminin-11 complex GO:0043260 9.16 LAMB2 LAMC1
8 extracellular matrix GO:0031012 9.02 AGRN LAMB1 LAMB2 LAMC1 TGFB1
9 laminin-10 complex GO:0043259 8.96 LAMB1 LAMC1

Biological processes related to Diffuse Mesangial Sclerosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 endoderm development GO:0007492 9.51 LAMC1 TGFB1
2 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.49 PAX2 TGFB1
3 regulation of actin cytoskeleton reorganization GO:2000249 9.48 ARHGDIA TGFB1
4 cell activation GO:0001775 9.46 PDGFA TGFB1
5 mesenchymal to epithelial transition GO:0060231 9.43 PAX2 WT1
6 glomerulus development GO:0032835 9.4 PLCE1 WT1
7 glomerular basement membrane development GO:0032836 9.37 NPHS1 WT1
8 extracellular matrix organization GO:0030198 9.35 AGRN LAMB1 LAMB2 LAMC1 PDGFA
9 metanephric mesenchyme development GO:0072075 9.32 PAX2 WT1
10 metanephric epithelium development GO:0072207 9.26 PAX2 WT1
11 metanephric glomerular visceral epithelial cell development GO:0072249 9.16 LAMB2 NPHS2
12 positive regulation of epithelial cell proliferation GO:0050679 8.92 LAMB1 LAMC1 PAX2 TGFB1

Sources for Diffuse Mesangial Sclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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