MCID: DFF004
MIFTS: 36

Diffuse Peritoneal Leiomyomatosis

Categories: Cancer diseases

Aliases & Classifications for Diffuse Peritoneal Leiomyomatosis

MalaCards integrated aliases for Diffuse Peritoneal Leiomyomatosis:

Name: Diffuse Peritoneal Leiomyomatosis 12 15
Leiomyomatosis Peritonealis Disseminata 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5728
NCIt 51 C3958
SNOMED-CT 69 62557001
UMLS 74 C0267785

Summaries for Diffuse Peritoneal Leiomyomatosis

Disease Ontology : 12 A peritoneal benign neoplasm that is located throughout the peritoneum and derives from smooth muscle.

MalaCards based summary : Diffuse Peritoneal Leiomyomatosis, also known as leiomyomatosis peritonealis disseminata, is related to endometriosis of ovary and myoma. An important gene associated with Diffuse Peritoneal Leiomyomatosis is PRND (Prion Like Protein Doppel), and among its related pathways/superpathways is Nuclear Receptor transcription pathway. Affiliated tissues include smooth muscle, uterus and liver, and related phenotypes are cellular and embryo

Related Diseases for Diffuse Peritoneal Leiomyomatosis

Diseases related to Diffuse Peritoneal Leiomyomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 endometriosis of ovary 31.0 ESR1 PGR
2 myoma 30.9 ESR1 MED12 PGR
3 leiomyomatosis 30.7 ESR1 MED12 PGR
4 leiomyosarcoma 30.5 KIT MED12 PGR WT1
5 ovarian brenner tumor 30.3 CALB2 KIT WT1
6 leiomyoma 30.1 CD34 ESR1 KIT MED12 PGR
7 disseminated peritoneal leiomyomatosis 11.6
8 intravenous leiomyomatosis 11.1
9 endometriosis 10.9
10 bizarre leiomyoma 10.4 MED12 PGR
11 vestibular gland benign neoplasm 10.4 ESR1 PGR
12 bartholin's gland adenoma 10.4 ESR1 PGR
13 currarino syndrome 10.4
14 sarcoma 10.4
15 endometrial adenocarcinoma 10.4
16 adenocarcinoma 10.4
17 vulvar syringoma 10.4 ESR1 PGR
18 lung leiomyoma 10.4 ESR1 PGR
19 glassy cell carcinoma of the cervix 10.4 ESR1 PGR
20 predominantly cortical thymoma 10.4 ESR1 PGR
21 breast medullary carcinoma 10.3 ESR1 PGR
22 breast scirrhous carcinoma 10.3 ESR1 PGR
23 bartholin's gland benign neoplasm 10.3 ESR1 PGR
24 progesterone-receptor positive breast cancer 10.3 ESR1 PGR
25 progesterone resistance 10.3 ESR1 PGR
26 endometrial mucinous adenocarcinoma 10.3 ESR1 PGR
27 synchronous bilateral breast carcinoma 10.3 ESR1 PGR
28 endosalpingiosis 10.3 PGR WT1
29 cervical carcinosarcoma 10.3 ESR1 PGR
30 estrogen excess 10.3 ESR1 PGR
31 glycogen-rich clear cell breast carcinoma 10.3 ESR1 PGR
32 mammographic density 10.3 ESR1 PGR
33 cervical clear cell adenocarcinoma 10.3 ESR1 PGR
34 retinitis pigmentosa 47 10.3 ESR1 PGR
35 inflammatory breast carcinoma 10.3 ESR1 PGR
36 retinitis pigmentosa 20 10.3 ESR1 PGR
37 benign breast phyllodes tumor 10.3 KIT PGR
38 luminal breast carcinoma 10.3 ESR1 PGR
39 testicular gonadoblastoma 10.3 KIT WT1
40 gonadoblastoma 10.3 KIT WT1
41 breast giant fibroadenoma 10.3 ESR1 WT1
42 uterine corpus cancer 10.3 ESR1 PGR
43 perivascular epithelioid cell tumor 10.3 KIT PGR
44 corneal abscess 10.3 AR PGR
45 prostate stromal sarcoma 10.3 CD34 PGR
46 postmenopausal atrophic vaginitis 10.3 AR ESR1
47 bartholin's gland disease 10.3 AR PGR
48 hypereosinophilic syndrome, idiopathic 10.3 KIT WT1
49 vaginitis 10.3 AR ESR1
50 lung meningioma 10.3 CD34 PGR

Graphical network of the top 20 diseases related to Diffuse Peritoneal Leiomyomatosis:



Diseases related to Diffuse Peritoneal Leiomyomatosis

Symptoms & Phenotypes for Diffuse Peritoneal Leiomyomatosis

MGI Mouse Phenotypes related to Diffuse Peritoneal Leiomyomatosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.01 AR CD34 ESR1 KIT MED12 PGR
2 embryo MP:0005380 9.85 AR ESR1 KIT MED12 PGR WT1
3 integument MP:0010771 9.8 AR CD34 ESR1 KIT PGR USF2
4 limbs/digits/tail MP:0005371 9.73 AR ESR1 KIT MED12 PGR USF2
5 neoplasm MP:0002006 9.63 AR CD34 ESR1 KIT PGR WT1
6 normal MP:0002873 9.56 AR CALB2 ESR1 KIT MED12 PGR
7 reproductive system MP:0005389 9.17 AR ESR1 KIT PGR PRND USF2

Drugs & Therapeutics for Diffuse Peritoneal Leiomyomatosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 French National Registry of Rare Peritoneal Surface Malignancies Active, not recruiting NCT02834169

Search NIH Clinical Center for Diffuse Peritoneal Leiomyomatosis

Genetic Tests for Diffuse Peritoneal Leiomyomatosis

Anatomical Context for Diffuse Peritoneal Leiomyomatosis

MalaCards organs/tissues related to Diffuse Peritoneal Leiomyomatosis:

42
Smooth Muscle, Uterus, Liver, Colon, Lymph Node, Ovary, Adipocyte

Publications for Diffuse Peritoneal Leiomyomatosis

Articles related to Diffuse Peritoneal Leiomyomatosis:

(show top 50) (show all 133)
# Title Authors Year
1
Morcellation-Induced Leiomyomatosis Peritonealis Disseminata: A Rare Case Report. ( 30666077 )
2019
2
Leiomyomatosis peritonealis disseminata: A case report of recurrent presentation and literature review. ( 29933173 )
2018
3
Leiomyomatosis peritonealis disseminata in a nonpregnant woman. ( 30693147 )
2018
4
Leiomyomatosis peritonealis disseminata. ( 28408050 )
2017
5
Diffuse peritoneal leiomyomatosis status post laparoscopic hysterectomy with power morcellation: A case report with review of literature. ( 28203626 )
2017
6
Long-term efficacy and safety of aromatase inhibitor use for leiomyomatosis peritonealis disseminata. ( 28691239 )
2017
7
Leiomyomatosis peritonealis disseminata: A case report and meticulous review of the literature. ( 28965085 )
2017
8
Imaging Findings in a Rare Case of Leiomyomatosis Peritonealis Disseminata with Malignant Transformation. ( 29662568 )
2017
9
Iatrogenic parasitic leiomyoma and leiomyomatosis peritonealis disseminata following uterine morcellation. ( 27125448 )
2016
10
Leiomyomatosis Peritonealis Disseminata (LPD) ten years after laparoscopic myomectomy associated with ascites and lymph nodes enlargement: a case report. ( 27280492 )
2016
11
Leiomyomatosis peritonealis disseminata in postmenopausal women: a case report with review of literature. ( 27785109 )
2016
12
A Rare Concurrence of Leiomyomatosis Peritonealis Disseminata, Leiomyosarcoma of the Pelvis and Leiomyomatous Nodule of the Liver. ( 26998373 )
2016
13
Leiomyomatosis peritonealis disseminata: case report and review of the literature. ( 27426654 )
2016
14
Leiomyomatosis peritonealis disseminata: A case report and review of the literature. ( 27284430 )
2016
15
Leiomyomatosis peritonealis disseminata associated with endometriosis: A case report and review of the literature. ( 25621042 )
2015
16
Leiomyomatosis peritonealis disseminata associated with appendiceal endometriosis: a case report. ( 26215629 )
2015
17
Leiomyomatosis peritonealis disseminata of unusual course with malignant transformation: case report. ( 25546607 )
2015
18
Leiomyomatosis Peritonealis Disseminata That Caused Hydroureter in Association With Deep Infiltrating Endometriosis. ( 27678704 )
2015
19
A Novel Molecular Cytogenetic Finding of Leiomyomatosis Peritonealis Disseminata. ( 25925998 )
2015
20
Leiomyomatosis peritonealis disseminata positive for progesterone receptor. ( 25992687 )
2015
21
Leiomyomatosis peritonealis disseminata: an additional case. ( 24772927 )
2014
22
Recurrent diffuse peritoneal leiomyomatosis following leiomyomata uterus. ( 25404829 )
2014
23
Selected case from the Arkadi M. Rywlin International Pathology Slide Series: Leiomyomatosis peritonealis disseminata: report of 3 cases with extensive review of the literature. ( 24713991 )
2014
24
Symptom relief of leiomyomatosis peritonealis disseminata with ulipristal acetate. ( 24611038 )
2014
25
Leiomyomatosis peritonealis disseminata coexisting with endometriosis within the same lesions: a case report with review of the literature. ( 24294383 )
2013
26
Mutation status of the mediator complex subunit 12 (MED12) in uterine leiomyomas and concurrent/metachronous multifocal peritoneal smooth muscle nodules (leiomyomatosis peritonealis disseminata). ( 23635816 )
2013
27
Leiomyomatosis peritonealis disseminata: pregnancy, contraception and myomectomy of its pathogenesis. ( 24047039 )
2013
28
Diffuse peritoneal leiomyomatosis. ( 23815223 )
2013
29
Leiomyomatosis peritonealis disseminata with formation of endometrial cysts within tumors arising after supracervical laparoscopic hysterectomy. ( 23488314 )
2013
30
Leiomyomatosis peritonealis disseminata associated with ascites and endometriosis: a case report and review of the literature. ( 24294802 )
2013
31
Leiomyomatosis peritonealis disseminata presenting as omental torsion. ( 22511066 )
2012
32
Leiomyomatosis peritonealis disseminata in a Nigerian woman. ( 23293420 )
2012
33
Leiomyomatosis peritonealis disseminata and pregnancy: a case report. ( 23444765 )
2012
34
Leiomyomatosis peritonealis disseminata associated with endometriosis and multiple uterus-like mass: report of two cases. ( 22661902 )
2012
35
Leiomyomatosis peritonealis disseminata with malignant degeneration. A case report. ( 22335043 )
2011
36
Leiomyomatosis peritonealis disseminata: an unusual presentation. ( 20143995 )
2010
37
Pathophysiology and possible iatrogenic cause of leiomyomatosis peritonealis disseminata. ( 20068330 )
2010
38
Leiomyomatosis peritonealis disseminata in a 50-year-old woman: imaging findings. ( 20957890 )
2010
39
Leiomyomatosis peritonealis disseminata in a pregnant woman. ( 19370358 )
2010
40
Radical surgical cytoreduction of progressive leiomyomatosis peritonealis disseminata: a case report. ( 19691262 )
2009
41
Leiomyomatosis Peritonealis Disseminata with Features of Carcinomatosis on Laparoscopy: A case report. ( 21509316 )
2009
42
MR and CT findings of leiomyomatosis peritonealis disseminata with emphasis on assisted reproductive technology as a risk factor. ( 19211902 )
2009
43
Multimodality imaging findings of leiomyomatosis peritonealis disseminata. ( 19173236 )
2009
44
Leiomyomatosis peritonealis disseminata and subcutaneous myoma--a rare complication of laparoscopic myomectomy. ( 18311496 )
2009
45
Leiomyomatosis peritonealis disseminata associated with endocervicosis. ( 19302758 )
2009
46
Live birth of a normal mature healthy baby by in vitro fertilization-embryo transfer (IVF-ET) after an exploratory laparotomy and multiple myomectomy for leiomyomatosis peritonealis disseminata. ( 19268933 )
2009
47
Successful management of a leiomyomatosis peritonealis disseminata with an aromatase inhibitor. ( 18669776 )
2008
48
Leiomyomatosis peritonealis disseminata presenting with intravascular extension and coexisting with endometriosis: a case report. ( 17583244 )
2007
49
Computed tomography of pancreatic implantation with malignant transformation of leiomyomatosis peritonealis disseminata in a man. ( 17415642 )
2007
50
Leiomyomatosis peritonealis disseminata in association with Currarino syndrome? ( 16686944 )
2006

Variations for Diffuse Peritoneal Leiomyomatosis

Expression for Diffuse Peritoneal Leiomyomatosis

Search GEO for disease gene expression data for Diffuse Peritoneal Leiomyomatosis.

Pathways for Diffuse Peritoneal Leiomyomatosis

Pathways related to Diffuse Peritoneal Leiomyomatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.75 AR ESR1 PGR

GO Terms for Diffuse Peritoneal Leiomyomatosis

Biological processes related to Diffuse Peritoneal Leiomyomatosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription by RNA polymerase II GO:0006357 9.91 AR ESR1 KIT MED12 USF2 WT1
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.8 AR ESR1 MED12 PGR USF2 WT1
3 positive regulation of gene expression GO:0010628 9.78 AR CD34 KIT WT1
4 positive regulation of transcription, DNA-templated GO:0045893 9.77 AR ESR1 MED12 USF2 WT1
5 intracellular receptor signaling pathway GO:0030522 9.55 AR ESR1
6 transcription, DNA-templated GO:0006351 9.54 AR ESR1
7 stem cell differentiation GO:0048863 9.52 ESR1 KIT
8 intracellular steroid hormone receptor signaling pathway GO:0030518 9.51 ESR1 MED12
9 mammary gland alveolus development GO:0060749 9.49 AR ESR1
10 positive regulation of phospholipase C activity GO:0010863 9.46 ESR1 KIT
11 steroid hormone mediated signaling pathway GO:0043401 9.43 AR ESR1 PGR
12 paracrine signaling GO:0038001 9.4 CD34 PGR
13 transcription initiation from RNA polymerase II promoter GO:0006367 9.26 AR ESR1 MED12 PGR
14 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 9.16 AR PGR
15 male gonad development GO:0008584 8.92 AR ESR1 KIT WT1

Molecular functions related to Diffuse Peritoneal Leiomyomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.83 AR ESR1 PGR USF2 WT1
2 transcription factor binding GO:0008134 9.71 AR CD34 ESR1 MED12
3 sequence-specific DNA binding GO:0043565 9.65 AR ESR1 PGR USF2 WT1
4 beta-catenin binding GO:0008013 9.54 AR ESR1 MED12
5 ATPase binding GO:0051117 9.5 AR ESR1 PGR
6 steroid hormone receptor activity GO:0003707 9.33 AR ESR1 PGR
7 nuclear receptor activity GO:0004879 9.13 AR ESR1 PGR
8 steroid binding GO:0005496 8.8 AR ESR1 PGR

Sources for Diffuse Peritoneal Leiomyomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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