DPL
MCID: DFF004
MIFTS: 30

Diffuse Peritoneal Leiomyomatosis (DPL)

Categories: Cancer diseases, Muscle diseases, Rare diseases

Aliases & Classifications for Diffuse Peritoneal Leiomyomatosis

MalaCards integrated aliases for Diffuse Peritoneal Leiomyomatosis:

Name: Diffuse Peritoneal Leiomyomatosis 12 20 58 15
Disseminated Peritoneal Leiomyomatosis 20 58 17
Leiomyomatosis Peritonealis Disseminata 12 70
Leiomyomatosis Peritonealis Disseminate 20 58
Dpl 20 58
Lpd 20 58

Characteristics:

Orphanet epidemiological data:

58
disseminated peritoneal leiomyomatosis
Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:5728
NCIt 50 C3958
SNOMED-CT 67 62557001
ICD10 via Orphanet 33 D20.1
Orphanet 58 ORPHA71274
UMLS 70 C0267785

Summaries for Diffuse Peritoneal Leiomyomatosis

GARD : 20 Disseminated peritoneal leiomyomatosis (DPL) is a rare condition which is characterized by nodules or small lumps of smooth muscle cells located on the peritoneum (lining of the abdominal wall) and abdominal organs.The condition is usually benign (noncancerous) but in rare cases has become cancerous. Although it can be seen in post-menopausal women and very rarely in men, DPL occurs most often in women of childbearing age. Most women with DPL are pregnant, taking the birth control pill, or have uterine leioyomas or estrogen -secreting tumors. Some people with DPL have no signs or symptoms of the condition. When present, symptoms may include abdominal and pelvic pain; rectal or vaginal bleeding; and less commonly constipation. The cause of DPL is unknown but may be linked to hormonal and genetic factors. Some cases of DPL resolve when hormone levels are returned to normal. However, surgery may be suggested based on the size and location of the tumor.

MalaCards based summary : Diffuse Peritoneal Leiomyomatosis, also known as disseminated peritoneal leiomyomatosis, is related to leiomyosarcoma and endometriosis. An important gene associated with Diffuse Peritoneal Leiomyomatosis is PGR (Progesterone Receptor), and among its related pathways/superpathways are Smooth Muscle Contraction and Ovarian Infertility Genes. Affiliated tissues include smooth muscle and uterus, and related phenotype is skeleton.

Disease Ontology : 12 A peritoneal benign neoplasm that is located throughout the peritoneum and derives from smooth muscle.

Related Diseases for Diffuse Peritoneal Leiomyomatosis

Diseases related to Diffuse Peritoneal Leiomyomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 31.4 PGR MED12
2 endometriosis 30.9 PGR GNRH1 CYP19A1
3 cellular leiomyoma 30.7 MED12 CALD1
4 ovarian cyst 30.7 GNRH1 CYP19A1
5 smooth muscle tumor 30.6 PGR MED12 CALD1
6 leiomyoma 30.6 PGR MED12 GNRH1 CYP19A1
7 benign metastasizing leiomyoma 30.5 PGR CYP19A1
8 leiomyoma, uterine 30.5 PGR GNRH1 CYP19A1
9 intravenous leiomyomatosis 30.4 PGR MED12 CALD1
10 estrogen excess 30.3 PGR GNRH1 CYP19A1
11 endometriosis of ovary 30.3 PGR GNRH1 CYP19A1
12 leiomyomatosis 30.3 PGR MED12 GNRH1
13 bizarre leiomyoma 30.2 PGR MED12 CALD1
14 adenomyosis 30.1 PGR GNRH1 CYP19A1
15 myoma 29.7 PGR MED12 GNRH1 CYP19A1 CALD1
16 adenomyoma 29.4 PGR MED12 GNRH1 CALD1
17 methotrexate-associated lymphoproliferative disorders 11.0
18 systemic epstein-barr virus-positive t-cell lymphoproliferative disease of childhood 11.0
19 myofibroma 10.5
20 endometrial cancer 10.4
21 appendicitis 10.4
22 intestinal obstruction 10.4
23 lymphoproliferative syndrome 10.4
24 currarino syndrome 10.2
25 sacral defect with anterior meningocele 10.2
26 gastrointestinal stromal tumor 10.2
27 constipation 10.2
28 ovarian brenner tumor 10.2
29 benign mesothelioma 10.2
30 endometrial adenocarcinoma 10.2
31 pseudomyxoma peritonei 10.2
32 bilateral breast cancer 10.2
33 villoglandular endometrial endometrioid adenocarcinoma 10.2
34 gliomatosis peritonei 10.2
35 prurigo nodularis 10.2
36 raynaud phenomenon 10.2
37 prion disease 10.2
38 pulmonary vein leiomyosarcoma 10.2 PGR CALD1
39 lung leiomyoma 10.2 PGR CALD1
40 cervical polyp 10.2 PGR CALD1
41 vaginal endometrial stromal sarcoma 10.2 PGR CALD1
42 vulvar leiomyoma 10.2 PGR CALD1
43 myxoid leiomyosarcoma 10.1 PGR CALD1
44 vagina sarcoma 10.1 PGR CALD1
45 urethral benign neoplasm 10.1 PGR CALD1
46 cervical adenoma malignum 10.1 PGR CALD1
47 uterus leiomyosarcoma 10.1 PGR CALD1
48 glioma susceptibility 1 10.1
49 malignant astrocytoma 10.1
50 cervical adenosarcoma 10.1 PGR CALD1

Graphical network of the top 20 diseases related to Diffuse Peritoneal Leiomyomatosis:



Diseases related to Diffuse Peritoneal Leiomyomatosis

Symptoms & Phenotypes for Diffuse Peritoneal Leiomyomatosis

MGI Mouse Phenotypes related to Diffuse Peritoneal Leiomyomatosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 skeleton MP:0005390 9.02 ACTG2 CYP19A1 GNRH1 MED12 PGR

Drugs & Therapeutics for Diffuse Peritoneal Leiomyomatosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 French National Registry of Rare Peritoneal Surface Malignancies (RENAPE Registry) Unknown status NCT02834169

Search NIH Clinical Center for Diffuse Peritoneal Leiomyomatosis

Genetic Tests for Diffuse Peritoneal Leiomyomatosis

Anatomical Context for Diffuse Peritoneal Leiomyomatosis

MalaCards organs/tissues related to Diffuse Peritoneal Leiomyomatosis:

40
Smooth Muscle, Uterus

Publications for Diffuse Peritoneal Leiomyomatosis

Articles related to Diffuse Peritoneal Leiomyomatosis:

(show top 50) (show all 111)
# Title Authors PMID Year
1
Diffuse Micro-Nodules on Peritoneal Surfaces at Donor Organ Procurement: Highlights on the Diagnostic Challenge and Transplant Management. 61
33579891 2021
2
Peritoneal lymphomatosis. A case report. 61
33485812 2020
3
A case of colorectal large cell neuroendocrine carcinoma accompanied by disseminated peritoneal leiomyomatosis. 61
33296060 2020
4
Diffuse peritoneal leiomyomatosis: An exceptional entity in a male patient. 61
33380682 2020
5
Cluster of "Grapes" in the Pelvis: A Sporadic Case of Disseminated Peritoneal Leiomyomatosis with Endometriosis. 61
31843697 2020
6
The Uterine Plexiform Lesions Revisited. 61
32459343 2020
7
A clinicopathological and molecular analysis in uterine leiomyomas and concurrent/metachronous peritoneal nodules: New insights into disseminated peritoneal leiomyomatosis. 61
32234244 2020
8
Disseminated peritoneal leiomyomatosis: an unusual presentation of intra-abdominal lesion mimicking disseminated malignancy. 61
32133455 2020
9
Disseminated peritoneal leiomyomatosis after uterine artery embolization, laparoscopic surgery, and high intensity focused ultrasound for uterine fibroids:a case report. 61
32752969 2020
10
Disseminated peritoneal leiomyomatosis: a devastating sequelae of unconfined laparoscopic morcellation. 61
31889207 2019
11
Disseminated peritoneal leiomyomatosis, a diagnostic challenge. 61
30772089 2019
12
Disseminated peritoneal leiomyomatosis following laparoscopic myomectomy: a case report. 61
31500489 2019
13
Gastrointestinal stromal tumor coexisting with disseminated peritoneal leiomyomatosis. 61
31410732 2019
14
Natural history of leiomyomas beyond the uterus. 61
31232922 2019
15
Lung metastases from benign uterine leiomyoma: does 18-FDG-PET/CT have a role to play? 61
30074141 2019
16
Ulipristal Acetate for Disseminated Peritoneal Leiomyomatosis. 61
30741799 2019
17
Disseminated Peritoneal Leiomyomatosis. 61
29959641 2019
18
Simultaneously occurring disseminated peritoneal leiomyomatosis and multiple extrauterine adenomyomas following hysterectomy. 61
30956607 2019
19
[Smooth muscle tumors of uncertain malignant potential]. 61
31317925 2019
20
Disseminated Peritoneal Leiomyomatosis After Uterine Artery Embolization. 61
30088058 2018
21
Disseminated peritoneal leiomyomatosis (DPL): a case report. 61
29620425 2018
22
Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis. 61
30096934 2018
23
Disseminated peritoneal leiomyomatosis 10 years after a laparoscopic myomectomy: A brief communication. 61
29547807 2018
24
Laparoscopic Dissection of Extensive Secondary Disseminated Peritoneal Leiomyomatosis. 61
29032253 2018
25
Disseminated Peritoneal Leiomyomatosis. 61
29112636 2017
26
Long-term sequelae of unconfined morcellation during laparoscopic gynecological surgery. 61
28159054 2017
27
Diffuse peritoneal leiomyomatosis status post laparoscopic hysterectomy with power morcellation: A case report with review of literature. 61
28203626 2017
28
A case of disseminated peritoneal leiomyomatosis after two laparoscopic procedures due to uterine fibroids. 61
28446940 2017
29
A Diagnostic Dilemma of Recurrent Disseminated Peritoneal Leiomyomatosis with Hypertrophied Omental Vessels: Imaging and Embolization of Omental Branches with Positive Outcome. 61
28251003 2017
30
A Case of Simultaneous Benign Metastasizing Leiomyomas and Disseminated Peritoneal Leiomyomatosis Following Endoscopic Power Morcellation for Uterine Disease. 61
27748666 2017
31
Disseminated peritoneal leiomyomatosis incidentally discovered during laparoscopic surgery. 61
30254869 2017
32
Disseminated Peritoneal Leiomyomatosis Status Post Laparoscopic Hysterectomy with Morcellation. 61
28580061 2016
33
Disseminated peritoneal leiomyomatosis postmorcellated resection of uterine leiomyomatous tissue. 61
27649643 2016
34
[A Case of Disseminated Peritoneal Leiomyomatosis with Several Recurrences]. 61
28133100 2016
35
Parasitic leiomyomas: a systematic review. 61
27359081 2016
36
Nonmalignant Sequelae of Unconfined Morcellation at Laparoscopic Hysterectomy or Myomectomy. 61
26802909 2016
37
[DISSEMINATED PERITONEAL LEYOMYOMATOSIS AFTER LAPAROSCOPIC MORCELLATION--A CASE REPORT]. 61
27514144 2016
38
Disseminated peritoneal leiomyomatosis: a rare cause of enigmatic peritoneal masses. 61
30459968 2016
39
[DISSEMINATED PERITONEAL LEYOMYOMATOSIS--PRACTICAL APPROACH TO DIAGNOSIS]. 61
27509658 2016
40
Disseminated Peritoneal Leiomyomatosis After Open Power Morcellation: A Case Report. 61
27679078 2015
41
Single-port laparoscopic debulking surgery of variant benign metastatic leiomyomatosis with simultaneous lymphatic spreading and intraperitoneal seeding. 61
26217603 2015
42
Imaging diagnosis--disseminated peritoneal leiomyomatosis in a dog. 61
24870205 2015
43
Leiomyomatosis peritonealis disseminata of unusual course with malignant transformation: case report. 61
25546607 2015
44
Leiomyomas beyond the uterus; benign metastasizing leiomyomatosis with paraaortic metastasizing endometriosis and intravenous leiomyomatosis: a case series and review of the literature. 61
25047270 2015
45
Recurrent diffuse peritoneal leiomyomatosis following leiomyomata uterus. 61
25404829 2014
46
CT imaging of peritoneal carcinomatosis and its mimics. 61
24631039 2014
47
Disseminated peritoneal leiomyomatosis with chronic constipation: a case report. 61
24708548 2014
48
Disseminated peritoneal leiomyomatosis clinically and radiologically mimicking malignancy. 61
24196195 2014
49
Cotyledonoid dissecting leiomyoma of the uterus with intravascular luminal growth: a case study. 61
24255637 2013
50
Diffuse peritoneal leiomyomatosis. 61
23815223 2013

Variations for Diffuse Peritoneal Leiomyomatosis

Expression for Diffuse Peritoneal Leiomyomatosis

Search GEO for disease gene expression data for Diffuse Peritoneal Leiomyomatosis.

Pathways for Diffuse Peritoneal Leiomyomatosis

Pathways related to Diffuse Peritoneal Leiomyomatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.51 CALD1 ACTG2
2 10.13 PGR CYP19A1

GO Terms for Diffuse Peritoneal Leiomyomatosis

Biological processes related to Diffuse Peritoneal Leiomyomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle contraction GO:0006936 8.62 CALD1 ACTG2

Sources for Diffuse Peritoneal Leiomyomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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