DPL
MCID: DFF004
MIFTS: 29

Diffuse Peritoneal Leiomyomatosis (DPL)

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Diffuse Peritoneal Leiomyomatosis

MalaCards integrated aliases for Diffuse Peritoneal Leiomyomatosis:

Name: Diffuse Peritoneal Leiomyomatosis 12 52 58 15
Disseminated Peritoneal Leiomyomatosis 52 58 17
Leiomyomatosis Peritonealis Disseminata 12 71
Leiomyomatosis Peritonealis Disseminate 52 58
Dpl 52 58
Lpd 52 58

Characteristics:

Orphanet epidemiological data:

58
disseminated peritoneal leiomyomatosis
Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:



External Ids:

Disease Ontology 12 DOID:5728
NCIt 49 C3958
SNOMED-CT 67 62557001 703634007
ICD10 via Orphanet 33 D20.1
Orphanet 58 ORPHA71274
UMLS 71 C0267785

Summaries for Diffuse Peritoneal Leiomyomatosis

NIH Rare Diseases : 52 Disseminated peritoneal leiomyomatosis (DPL) is a rare condition which is characterized by nodules or small lumps of smooth muscle cells located on the peritoneum (lining of the abdominal wall) and abdominal organs .The condition is usually benign (noncancerous) but in rare cases has become cancerous . Although it can be seen in post-menopausal women and very rarely in men, DPL occurs most often in women of childbearing age. Most women with DPL are pregnant, taking the birth control pill, or have uterine leioyomas or estrogen -secreting tumors . Some people with DPL have no signs or symptoms of the condition. When present, symptoms may include abdominal and pelvic pain; rectal or vaginal bleeding; and less commonly constipation . The cause of DPL is unknown but may be linked to hormonal and genetic factors. Some cases of DPL resolve when hormone levels are returned to normal. However, surgery may be suggested based on the size and location of the tumor.

MalaCards based summary : Diffuse Peritoneal Leiomyomatosis, also known as disseminated peritoneal leiomyomatosis, is related to leiomyosarcoma and leiomyoma. An important gene associated with Diffuse Peritoneal Leiomyomatosis is PGR (Progesterone Receptor), and among its related pathways/superpathways are Ovarian Infertility Genes and Hormone ligand-binding receptors. Affiliated tissues include smooth muscle, uterus and lung, and related phenotype is reproductive system.

Disease Ontology : 12 A peritoneal benign neoplasm that is located throughout the peritoneum and derives from smooth muscle.

Related Diseases for Diffuse Peritoneal Leiomyomatosis

Diseases related to Diffuse Peritoneal Leiomyomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 31.5 PGR MED12
2 leiomyoma 31.1 PGR MED12 GNRH1
3 estrogen excess 30.9 PGR GNRH1
4 endometriosis of ovary 30.9 PGR GNRH1
5 cellular leiomyoma 30.8 MED12 CALD1
6 smooth muscle tumor 30.7 PGR MED12 CALD1
7 adenomyosis 30.6 PGR GNRH1
8 leiomyoma, uterine 30.5 PGR MED12 GNRH1
9 bizarre leiomyoma 30.2 PGR MED12 CALD1
10 intravenous leiomyomatosis 30.1 PGR MED12 CALD1
11 myoma 30.1 PGR MED12 GNRH1 CALD1
12 infertility 29.9 PGR LHCGR GNRH1
13 adenomyoma 29.1 PGR MED12 GNRH1 CALD1
14 leiomyomatosis 29.1 PGR MED12 LHCGR GNRH1
15 methotrexate-associated lymphoproliferative disorders 11.6
16 autoimmune lymphoproliferative syndrome 11.3
17 systemic epstein-barr virus-positive t-cell lymphoproliferative disease of childhood 11.2
18 endometriosis 11.0
19 myofibroma 10.6
20 endometrial cancer 10.5
21 ovarian cyst 10.5
22 appendicitis 10.5
23 intestinal obstruction 10.5
24 lymphoproliferative syndrome 10.5
25 prion disease 10.4
26 breast cancer 10.4
27 currarino syndrome 10.4
28 sacral defect with anterior meningocele 10.4
29 gastrointestinal stromal tumor 10.4
30 constipation 10.4
31 ovarian brenner tumor 10.4
32 benign mesothelioma 10.4
33 endometrial adenocarcinoma 10.4
34 pseudomyxoma peritonei 10.4
35 bilateral breast cancer 10.4
36 villoglandular endometrial endometrioid adenocarcinoma 10.4
37 48,xyyy 10.4
38 benign metastasizing leiomyoma 10.4
39 gliomatosis peritonei 10.4
40 prurigo nodularis 10.4
41 raynaud phenomenon 10.4
42 polydactyly 10.4
43 astrocytoma 10.4
44 encephalopathy 10.4
45 ataxia and polyneuropathy, adult-onset 10.3
46 scrapie 10.3
47 hypertriglyceridemia, familial 10.2
48 fatty liver disease, nonalcoholic 1 10.2
49 pulmonary vein leiomyosarcoma 10.2 PGR CALD1
50 lung leiomyoma 10.2 PGR CALD1

Graphical network of the top 20 diseases related to Diffuse Peritoneal Leiomyomatosis:



Diseases related to Diffuse Peritoneal Leiomyomatosis

Symptoms & Phenotypes for Diffuse Peritoneal Leiomyomatosis

MGI Mouse Phenotypes related to Diffuse Peritoneal Leiomyomatosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.02 GNRH1 LHCGR PGR PRND USF2

Drugs & Therapeutics for Diffuse Peritoneal Leiomyomatosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 French National Registry of Rare Peritoneal Surface Malignancies (RENAPE Registry) Unknown status NCT02834169

Search NIH Clinical Center for Diffuse Peritoneal Leiomyomatosis

Genetic Tests for Diffuse Peritoneal Leiomyomatosis

Anatomical Context for Diffuse Peritoneal Leiomyomatosis

MalaCards organs/tissues related to Diffuse Peritoneal Leiomyomatosis:

40
Smooth Muscle, Uterus, Lung

Publications for Diffuse Peritoneal Leiomyomatosis

Articles related to Diffuse Peritoneal Leiomyomatosis:

(show top 50) (show all 106)
# Title Authors PMID Year
1
A clinicopathological and molecular analysis in uterine leiomyomas and concurrent/metachronous peritoneal nodules: New insights into disseminated peritoneal leiomyomatosis. 61
32234244 2020
2
The Uterine Plexiform Lesions Revisited. 61
32459343 2020
3
Disseminated peritoneal leiomyomatosis: an unusual presentation of intra-abdominal lesion mimicking disseminated malignancy. 61
32133455 2020
4
Disseminated peritoneal leiomyomatosis: a devastating sequelae of unconfined laparoscopic morcellation. 61
31889207 2019
5
Cluster of "Grapes" in the Pelvis: A Sporadic Case of Disseminated Peritoneal Leiomyomatosis with Endometriosis. 61
31843697 2019
6
Disseminated peritoneal leiomyomatosis, a diagnostic challenge. 61
30772089 2019
7
Disseminated peritoneal leiomyomatosis following laparoscopic myomectomy: a case report. 61
31500489 2019
8
Gastrointestinal stromal tumor coexisting with disseminated peritoneal leiomyomatosis. 61
31410732 2019
9
Natural history of leiomyomas beyond the uterus. 61
31232922 2019
10
Lung metastases from benign uterine leiomyoma: does 18-FDG-PET/CT have a role to play? 61
30074141 2019
11
Disseminated Peritoneal Leiomyomatosis. 61
29959641 2019
12
Ulipristal Acetate for Disseminated Peritoneal Leiomyomatosis. 61
30741799 2019
13
Simultaneously occurring disseminated peritoneal leiomyomatosis and multiple extrauterine adenomyomas following hysterectomy. 61
30956607 2019
14
[Smooth muscle tumors of uncertain malignant potential]. 61
31317925 2019
15
Disseminated Peritoneal Leiomyomatosis After Uterine Artery Embolization. 61
30088058 2018
16
Disseminated peritoneal leiomyomatosis (DPL): a case report. 61
29620425 2018
17
Epithelial-Mesenchymal Transition with Malignant Transformation Leading Multiple Metastasis from Disseminated Peritoneal Leiomyomatosis. 61
30096934 2018
18
Laparoscopic Dissection of Extensive Secondary Disseminated Peritoneal Leiomyomatosis. 61
29032253 2018
19
Disseminated peritoneal leiomyomatosis 10 years after a laparoscopic myomectomy: A brief communication. 61
29547807 2018
20
Disseminated Peritoneal Leiomyomatosis. 61
29112636 2017
21
Long-term sequelae of unconfined morcellation during laparoscopic gynecological surgery. 61
28159054 2017
22
Diffuse peritoneal leiomyomatosis status post laparoscopic hysterectomy with power morcellation: A case report with review of literature. 61
28203626 2017
23
A Case of Simultaneous Benign Metastasizing Leiomyomas and Disseminated Peritoneal Leiomyomatosis Following Endoscopic Power Morcellation for Uterine Disease. 61
27748666 2017
24
A Diagnostic Dilemma of Recurrent Disseminated Peritoneal Leiomyomatosis with Hypertrophied Omental Vessels: Imaging and Embolization of Omental Branches with Positive Outcome. 61
28251003 2017
25
Disseminated peritoneal leiomyomatosis incidentally discovered during laparoscopic surgery. 61
30254869 2017
26
A case of disseminated peritoneal leiomyomatosis after two laparoscopic procedures due to uterine fibroids. 61
28446940 2017
27
Disseminated peritoneal leiomyomatosis postmorcellated resection of uterine leiomyomatous tissue. 61
27649643 2016
28
Disseminated Peritoneal Leiomyomatosis Status Post Laparoscopic Hysterectomy with Morcellation. 61
28580061 2016
29
[A Case of Disseminated Peritoneal Leiomyomatosis with Several Recurrences]. 61
28133100 2016
30
Parasitic leiomyomas: a systematic review. 61
27359081 2016
31
Nonmalignant Sequelae of Unconfined Morcellation at Laparoscopic Hysterectomy or Myomectomy. 61
26802909 2016
32
[DISSEMINATED PERITONEAL LEYOMYOMATOSIS AFTER LAPAROSCOPIC MORCELLATION--A CASE REPORT]. 61
27514144 2016
33
Disseminated peritoneal leiomyomatosis: a rare cause of enigmatic peritoneal masses. 61
30459968 2016
34
[DISSEMINATED PERITONEAL LEYOMYOMATOSIS--PRACTICAL APPROACH TO DIAGNOSIS]. 61
27509658 2016
35
Disseminated Peritoneal Leiomyomatosis After Open Power Morcellation: A Case Report. 61
27679078 2015
36
Single-port laparoscopic debulking surgery of variant benign metastatic leiomyomatosis with simultaneous lymphatic spreading and intraperitoneal seeding. 61
26217603 2015
37
Imaging diagnosis--disseminated peritoneal leiomyomatosis in a dog. 61
24870205 2015
38
Leiomyomatosis peritonealis disseminata of unusual course with malignant transformation: case report. 61
25546607 2015
39
Leiomyomas beyond the uterus; benign metastasizing leiomyomatosis with paraaortic metastasizing endometriosis and intravenous leiomyomatosis: a case series and review of the literature. 61
25047270 2015
40
Recurrent diffuse peritoneal leiomyomatosis following leiomyomata uterus. 61
25404829 2014
41
CT imaging of peritoneal carcinomatosis and its mimics. 61
24631039 2014
42
Disseminated peritoneal leiomyomatosis with chronic constipation: a case report. 61
24708548 2014
43
Disseminated peritoneal leiomyomatosis clinically and radiologically mimicking malignancy. 61
24196195 2014
44
Cotyledonoid dissecting leiomyoma of the uterus with intravascular luminal growth: a case study. 61
24255637 2013
45
Diffuse peritoneal leiomyomatosis. 61
23815223 2013
46
Disseminated peritoneal leiomyomatosis with endometriosis. 61
22546423 2012
47
Disseminated peritoneal leiomyomatosis after hysterectomy: a case report. 61
22010532 2011
48
Disseminated peritoneal leiyomyomatosis in an 18-year-old girl. 61
21397533 2011
49
Disseminated peritoneal leiomyomatosis. 61
23365481 2011
50
A case of disseminated peritoneal leiomyomatosis and diffuse uterine leiomyomatosis. 61
21485735 2011

Variations for Diffuse Peritoneal Leiomyomatosis

Expression for Diffuse Peritoneal Leiomyomatosis

Search GEO for disease gene expression data for Diffuse Peritoneal Leiomyomatosis.

Pathways for Diffuse Peritoneal Leiomyomatosis

Pathways related to Diffuse Peritoneal Leiomyomatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.46 PGR LHCGR
2 9.74 LHCGR GNRH1

GO Terms for Diffuse Peritoneal Leiomyomatosis

Sources for Diffuse Peritoneal Leiomyomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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