MCID: DFF002
MIFTS: 29

Diffuse Pulmonary Fibrosis

Categories: Respiratory diseases

Aliases & Classifications for Diffuse Pulmonary Fibrosis

MalaCards integrated aliases for Diffuse Pulmonary Fibrosis:

Name: Diffuse Pulmonary Fibrosis 12 55 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5641
NCIt 50 C27216
UMLS 73 C0865849

Summaries for Diffuse Pulmonary Fibrosis

MalaCards based summary : Diffuse Pulmonary Fibrosis is related to pulmonary hypertension and respiratory distress syndrome in premature infants. An important gene associated with Diffuse Pulmonary Fibrosis is ABCA3 (ATP Binding Cassette Subfamily A Member 3), and among its related pathways/superpathways are Lung fibrosis and Gastric acid production. Affiliated tissues include lung and thyroid, and related phenotypes are behavior/neurological and cardiovascular system

Related Diseases for Diffuse Pulmonary Fibrosis

Diseases related to Diffuse Pulmonary Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 pulmonary hypertension 28.3 CALCA GRP SFTPC VIP
2 respiratory distress syndrome in premature infants 10.9 ABCA3 SFTPC
3 neonatal respiratory failure 10.9 ABCA3 SFTPC
4 surfactant dysfunction 10.9 ABCA3 SFTPC
5 pauci-immune glomerulonephritis 10.8 BMP7 SMAD2
6 peritoneal serous adenocarcinoma 10.8 CHGA SFTPC
7 glucagonoma 10.7 CHGA VIP
8 anismus 10.6 TAC1 VIP
9 vipoma 10.6 CHGA VIP
10 newborn respiratory distress syndrome 10.6 ABCA3 SERPINH1 SFTPC
11 aplasia of lacrimal and salivary glands 10.6 AQP5 TAC1
12 penile disease 10.5 MRAP SMAD2
13 acinar cell cystadenocarcinoma 10.5 CHGA SERPINA1
14 cervix disease 10.5 MRAP SERPINH1
15 binswanger's disease 10.5 CHGA VIP
16 cryptosporidiosis 10.5 TAC1 VIP
17 pulmonary fibrosis 10.5
18 nonspecific interstitial pneumonia 10.4 SERPINH1 SFTPC
19 pancreatoblastoma 10.4 CHGA SERPINA1
20 ureter small cell carcinoma 10.4 CHGA ENO2
21 intracranial primitive neuroectodermal tumor 10.4 CHGA ENO2
22 auditory system cancer 10.3 CHGA ENO2
23 gallbladder small cell carcinoma 10.3 CHGA ENO2
24 transient arthritis 10.3 MRAP SERPINA1
25 small cell carcinoma of the bladder 10.3 CHGA ENO2
26 hypertrophic scars 10.3 SMAD2 TIMP1
27 epithelioid malignant peripheral nerve sheath tumor 10.3 CHGA ENO2
28 pulmonary large cell neuroendocrine carcinoma 10.3 CHGA ENO2
29 irritable bowel syndrome 10.3 CHGA TAC1 VIP
30 goblet cell carcinoid 10.3 CHGA ENO2
31 olfactory nerve neoplasm 10.3 CHGA ENO2
32 cauda equina neoplasm 10.3 CHGA ENO2
33 nodular ganglioneuroblastoma 10.3 CHGA ENO2
34 interstitial lung disease 10.3 ABCA3 SFTPC TIMP1
35 pineocytoma 10.3 CHGA ENO2
36 respiratory system benign neoplasm 10.3 CHGA ENO2
37 gastric squamous cell carcinoma 10.3 CHGA ENO2
38 gastric small cell carcinoma 10.2 CHGA ENO2
39 congenital granular cell tumor 10.2 ENO2 SERPINA1
40 subependymoma 10.2 CHGA ENO2
41 respiratory system disease 10.2 SERPINA1 SFTPC TAC1
42 carcinoid tumors, intestinal 10.2 CHGA ENO2
43 papillary ependymoma 10.2 CHGA ENO2
44 gastrinoma 10.2 CHGA VIP
45 wdha syndrome 10.2 CALCA VIP
46 endodermal sinus tumor 10.2 CHGA SERPINA1
47 bronchitis 10.2 SERPINA1 TAC1 VIP
48 leprosy 2 10.2 CALCA VIP
49 sclerosing hemangioma 10.1 CHGA ENO2
50 central neurocytoma 10.1 CHGA ENO2

Graphical network of the top 20 diseases related to Diffuse Pulmonary Fibrosis:



Diseases related to Diffuse Pulmonary Fibrosis

Symptoms & Phenotypes for Diffuse Pulmonary Fibrosis

MGI Mouse Phenotypes related to Diffuse Pulmonary Fibrosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.81 ABCA3 AQP5 BMP7 ENO2 GRP SFTPC
2 cardiovascular system MP:0005385 9.61 TIMP1 VIP ABCA3 BMP7 CHGA SERPINH1
3 respiratory system MP:0005388 9.28 ABCA3 AQP5 BMP7 ENO2 SERPINH1 SFTPC

Drugs & Therapeutics for Diffuse Pulmonary Fibrosis

Search Clinical Trials , NIH Clinical Center for Diffuse Pulmonary Fibrosis

Genetic Tests for Diffuse Pulmonary Fibrosis

Anatomical Context for Diffuse Pulmonary Fibrosis

MalaCards organs/tissues related to Diffuse Pulmonary Fibrosis:

41
Lung, Thyroid

Publications for Diffuse Pulmonary Fibrosis

Articles related to Diffuse Pulmonary Fibrosis:

(show all 42)
# Title Authors Year
1
Relationship between diffuse pulmonary fibrosis, alveolar proteinosis, and granulocyte-macrophage colony stimulating factor autoantibodies. ( 21513605 )
2011
2
The effect of diffuse pulmonary fibrosis on the reliability of CT signs of pulmonary hypertension. ( 19011195 )
2008
3
Nitric oxide in the pathogenesis of diffuse pulmonary fibrosis. ( 17291983 )
2007
4
Lung cancer associated with diffuse pulmonary fibrosis: CT-pathologic correlation. ( 12700479 )
2003
5
Hermansky-Pudlak syndrome with diffuse pulmonary fibrosis: radiologic-pathologic correlation. ( 9530389 )
1998
6
Pathogenic mechanisms in the development of diffuse pulmonary fibrosis. ( 9181054 )
1996
7
Diffuse pulmonary fibrosis and Hermansky-Pudlak syndrome. ( 7597682 )
1995
8
Diffuse pulmonary fibrosis and the Hermansky-Pudlak syndrome: clinical course and postmortem findings. ( 8016804 )
1994
9
Endocrine cells in diffuse pulmonary fibrosis. ( 8303633 )
1993
10
Scanning electron microscopic analysis of mineral fiber content of lung tissue in the evaluation of diffuse pulmonary fibrosis. ( 2052931 )
1991
11
Acquired tracheomegaly in adults as a complication of diffuse pulmonary fibrosis. ( 2784256 )
1989
12
Interaction of asbestos, age, and cigarette smoking in producing radiographic evidence of diffuse pulmonary fibrosis. ( 3953615 )
1986
13
Diffuse pulmonary fibrosis with airflow obstruction - clinical entities and classification. ( 6634633 )
1983
14
Experimental production of diffuse pulmonary fibrosis and alveolitis in cattle: the effects of repeated dosage with 3, methyl indole. ( 6836186 )
1983
15
Thromboxane and prostacyclin (epoprostenol) during exercise in diffuse pulmonary fibrosis. ( 6128494 )
1982
16
The effect of diffuse pulmonary fibrosis on lung mechanics. ( 7470684 )
1981
17
Lung elasticity in regional and diffuse pulmonary fibrosis. ( 89110 )
1979
18
Enzyme histochemical observations of diffuse pulmonary fibrosis of rats experimentally induced by ionizing irradiation. ( 1274581 )
1976
19
Diffuse pulmonary fibrosis-clinical observations, electronmicroscopic studies and serum protocollagen proline hydroxylase activity. ( 178052 )
1975
20
Diffuse pulmonary fibrosis and bilateral pneumothoraces in systemic lupus erythematosus. ( 1208295 )
1975
21
Non-tubercular diffuse pulmonary fibrosis in Northern India. ( 4655118 )
1972
22
Diffuse pulmonary fibrosis and hiatus hernia. ( 5089496 )
1971
23
Diffuse pulmonary fibrosis. ( 5521727 )
1970
24
Cigarette smoking and diffuse pulmonary fibrosis. ( 5762114 )
1969
25
Desquamative interstitial pneumonia and idiopathic diffuse pulmonary fibrosis; with their advanced final stages as "muscular cirrhosis of the lung" (diffuse bronchiolectasis with muscular hyperplasia). ( 5823898 )
1969
26
Diffuse pulmonary fibrosis [abstract]. ( 20919056 )
1968
27
Diffuse pulmonary fibrosis and blackfat-tobacco smoking in Guyana. ( 4173689 )
1968
28
Diffuse pulmonary fibrosis [abstract]. ( 20919055 )
1968
29
Diffuse pulmonary fibrosis [abstract]. ( 20919054 )
1968
30
Cigarette smoking and diffuse pulmonary fibrosis. A preliminary report. ( 6024481 )
1967
31
So-called bronchiolar emphysema. Its relatinhip to diffuse pulmonary fibrosis and pulmonary emphysema. ( 6059190 )
1967
32
Physiologic observations in diffuse pulmonary fibrosis and granulomatosis. ( 5918214 )
1966
33
AGRICULTURAL DUSTS AND DIFFUSE PULMONARY FIBROSIS. ( 14232912 )
1965
34
THE REGULATION OF VENTILATION IN DIFFUSE PULMONARY FIBROSIS. ( 14256716 )
1965
35
Nonoccupational diffuse pulmonary fibrosis. A report of a case in an asbestos worker. ( 13876979 )
1962
36
[Sclerous thyroiditis of sarcoidosic origin with myxedema and diffuse pulmonary fibrosis]. ( 13632105 )
1959
37
Diffuse pulmonary fibrosis. ( 13675016 )
1959
38
DIFFUSE pulmonary fibrosis. ( 13436806 )
1957
39
Clinical problems of diffuse pulmonary fibrosis. ( 13383135 )
1956
40
The treatment of pulmonary emphysema and of diffuse pulmonary fibrosis with nebulized bronchodilators and intermittent positive pressure breathing. ( 13251090 )
1955
41
Effect of cortisone on diffuse pulmonary fibrosis; interim report. ( 14893450 )
1951
42
Diffuse Pulmonary Fibrosis. ( 19988781 )
1932

Variations for Diffuse Pulmonary Fibrosis

Expression for Diffuse Pulmonary Fibrosis

Search GEO for disease gene expression data for Diffuse Pulmonary Fibrosis.

Pathways for Diffuse Pulmonary Fibrosis

Pathways related to Diffuse Pulmonary Fibrosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.82 BMP7 CALCA SERPINA1 SFTPC TIMP1
2 9.8 GRP VIP

GO Terms for Diffuse Pulmonary Fibrosis

Cellular components related to Diffuse Pulmonary Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 BMP7 CALCA CHGA GRP SERPINA1 SFTPC
2 extracellular space GO:0005615 9.36 ABCA3 BMP7 CALCA CHGA ENO2 GRP

Biological processes related to Diffuse Pulmonary Fibrosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of endopeptidase activity GO:0010951 9.61 SERPINA1 SERPINH1 TIMP1
2 regulation of signaling receptor activity GO:0010469 9.55 BMP7 CALCA GRP TIMP1 VIP
3 neuropeptide signaling pathway GO:0007218 9.54 CALCA GRP TAC1
4 embryonic pattern specification GO:0009880 9.49 BMP7 SMAD2
5 camera-type eye morphogenesis GO:0048593 9.48 AQP5 BMP7
6 response to pain GO:0048265 9.46 CALCA TAC1
7 regulation of blood pressure GO:0008217 9.43 CALCA CHGA TAC1
8 positive regulation of ossification GO:0045778 9.4 CALCA TAC1
9 positive regulation of cAMP metabolic process GO:0030816 9.32 CALCA CHGA
10 cellular protein metabolic process GO:0044267 9.02 ABCA3 CALCA SERPINA1 SFTPC TIMP1
11 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway GO:1900738 8.96 CHGA GRP

Molecular functions related to Diffuse Pulmonary Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 8.62 GRP VIP

Sources for Diffuse Pulmonary Fibrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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