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MCID: DLT002
MIFTS: 76

Dilated Cardiomyopathy

Categories: Rare diseases, Cardiovascular diseases, Genetic diseases, Neuronal diseases, Ear diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Dilated Cardiomyopathy

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MalaCards integrated aliases for Dilated Cardiomyopathy:

Name: Dilated Cardiomyopathy 38 12 76 24 53 37 29 55 6 15
Familial Dilated Cardiomyopathy 12 76 53 25 29 6 73
Idiopathic Dilation Cardiomyopathy 12 76 73
Primary Dilated Cardiomyopathy 12 29 6
Cardiomyopathy, Dilated 44 40 73
Congestive Cardiomyopathy 12 25
Hypokinetic Dilated Cardiomyopathy, Familial 53
Primary Familial Dilated Cardiomyopathy 25
Cardiomyopathy, Familial Idiopathic 73
Familial Idiopathic Cardiomyopathy 25
Idiopathic Dilated Cardiomyopathy 53
Cardiomyopathy, Familial Dilated 53
Dilated Cardiomyopathy, Familial 53
Fdc 25
Dcm 53

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Cardiovascular diseases Neuronal diseases Ear diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:12930
ICD10 33 I42.0
MeSH 44 D002311
NCIt 50 C84673
KEGG 37 H00294
Sources

Summaries for Dilated Cardiomyopathy

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NIH Rare Diseases : 53 Dilated cardiomyopathy (DCM) is a disease of the heart muscle which primarily affects the heart's main pumping chamber, the left ventricle. It is the most common type of cardiomyopathy and typically affects those aged 20 to 60. The left ventricle of affected individuals becomes enlarged (dilated) and cannot pump blood to the body with as much force as a healthy heart can. The heart muscle also has difficulty contracting normally, which can lead to irregular heartbeats (arrhythmia), blood clots, or sudden death. Over time, the heart becomes weaker and heart failure can occur. While the cause of dilated cardiomyopathy is often unknown (idiopathic), some cases are acquired and roughly half are inherited or familial. Also, DCM can be a feature of many genetic syndromes. Familial dilated cardiomyopathy is most often inherited in an autosomal dominant pattern. Familial dilated cardiomyopathy is caused by mutations in several different genes, most commonly in the TTN gene (found in about 20% of cases). DCM treatment may include medication, pacemakers, implantable cardiac defibrillators, or heart transplantation. 

MalaCards based summary : Dilated Cardiomyopathy, also known as familial dilated cardiomyopathy, is related to familial isolated dilated cardiomyopathy and cardiomyopathy, dilated, 1e. An important gene associated with Dilated Cardiomyopathy is LMNA (Lamin A/C), and among its related pathways/superpathways are Dilated cardiomyopathy (DCM) and Aldosterone synthesis and secretion. The drugs Amlodipine and Verapamil have been mentioned in the context of this disorder. Affiliated tissues include Heart and Heart, and related phenotypes are cardiovascular system and behavior/neurological

Disease Ontology : 12 An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently.

Genetics Home Reference : 25 Familial dilated cardiomyopathy is a genetic form of heart disease. It occurs when heart (cardiac) muscle becomes thin and weakened in at least one chamber of the heart, causing the open area of the chamber to become enlarged (dilated). As a result, the heart is unable to pump blood as efficiently as usual. To compensate, the heart attempts to increase the amount of blood being pumped through the heart, leading to further thinning and weakening of the cardiac muscle. Over time, this condition results in heart failure.

Wikipedia : 76 Dilated cardiomyopathy (DCM) is a condition in which the heart becomes enlarged and cannot pump blood... more...

GeneReviews: NBK1309
Sources

Related Diseases for Dilated Cardiomyopathy

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Diseases in the Dilated Cardiomyopathy family:

Cardiomyopathy, Dilated, 1a Cardiomyopathy, Dilated, 3b
Cardiomyopathy, Dilated, 1b Cardiomyopathy, Dilated, 1e
Cardiomyopathy, Dilated, 1d Cardiomyopathy, Dilated, 1g
Cardiomyopathy, Dilated, 1h Cardiomyopathy, Dilated, 1i
Cardiomyopathy, Dilated, 1j Cardiomyopathy, Dilated, 1k
Cardiomyopathy, Dilated, 1l Cardiomyopathy, Dilated, 1m
Cardiomyopathy, Dilated, 1o Cardiomyopathy, Dilated, 1p
Cardiomyopathy, Dilated, 1q Cardiomyopathy, Dilated, 1w
Cardiomyopathy, Dilated, 1x Cardiomyopathy, Dilated, 1z
Cardiomyopathy, Dilated, 2a Cardiomyopathy, Dilated, 1bb
Cardiomyopathy, Dilated, 1cc Cardiomyopathy, Dilated, 1dd
Cardiomyopathy, Dilated, 1ee Cardiomyopathy, Dilated, 1ff
Cardiomyopathy, Dilated, 1r Cardiomyopathy, Dilated, 1gg
Cardiomyopathy, Dilated, 1u Cardiomyopathy, Dilated, 1v
Cardiomyopathy, Dilated, 1hh Cardiomyopathy, Dilated, 2b
Cardiomyopathy, Dilated, 1ii Cardiomyopathy, Dilated, 1jj
Cardiomyopathy, Dilated, 1kk Cardiomyopathy, Dilated, 1nn
Dmd-Related Dilated Cardiomyopathy Dilated Cardiomyopathy 1t
Lmna-Related Dilated Cardiomyopathy Cardiomyopathy Due to Anthracyclines

Diseases related to Dilated Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 364)
# Related Disease Score Top Affiliating Genes
1 familial isolated dilated cardiomyopathy 36.9 BAG3 DES DMD LDB3 MYBPC3 MYH6
2 cardiomyopathy, dilated, 1e 36.0 DES DSP LMNA MYH7 NKX2-5 RBM20
3 cardiomyopathy, dilated, 3b 35.6 DMD TAZ
4 cardiomyopathy, dilated, 1b 35.3 DMD LDB3
5 cardiomyopathy, dilated, 1a 35.2 DMD LDB3 LMNA
6 cardiomyopathy, dilated, 1d 35.1 DMD LDB3 TNNT2
7 peripartum cardiomyopathy 34.6 MYH7 SCN5A TTN
8 myocarditis 34.5 DMD DSP MYH6 TNNI3
9 muscular dystrophy, congenital, 1b 34.2 DMD LDB3
10 congenital fiber-type disproportion 34.1 DMD LMNA MYH7
11 hypertrophic cardiomyopathy 33.8 DES DMD DSP LDB3 LMNA MYBPC3
12 myopathy 33.5 BAG3 DES DMD LDB3 LMNA MYH6
13 left ventricular noncompaction 33.3 DES DMD DSP LDB3 LMNA MYBPC3
14 myopathy, myofibrillar, 1 33.2 DES LDB3
15 heart disease 33.2 DSP LMNA MIR196A2 MYBPC3 MYH6 MYH7
16 cardiac conduction defect 33.1 DSP LMNA MYBPC3 MYH7 PLN SCN5A
17 arrhythmogenic right ventricular cardiomyopathy 32.8 DES DMD DSP LDB3 LMNA PLN
18 atrial standstill 1 32.8 DES DMD DSP LMNA MYBPC3 MYH6
19 congestive heart failure 32.7 MYH6 MYH7 PLN
20 restrictive cardiomyopathy 32.5 DES MYBPC3 MYH7 TNNI3 TNNT2 TPM1
21 atrioventricular block 32.3 LMNA NKX2-5 SCN5A
22 cardiac arrest 32.1 DSP MYBPC3 PLN SCN5A TNNT2
23 myofibrillar myopathy 32.0 BAG3 DES DMD LDB3
24 atrial heart septal defect 31.9 DMD MYH6 NKX2-5
25 sick sinus syndrome 31.9 LMNA MYH6 SCN5A
26 aortic valve disease 2 31.7 DSP MYH7 TNNI3
27 myosin storage myopathy 31.5 MYH6 MYH7
28 dilated cardiomyopathy 1t 12.3
29 cardiac conduction disease with or without dilated cardiomyopathy 12.3
30 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 12.2
31 dmd-related dilated cardiomyopathy 12.2
32 intrinsic cardiomyopathy 12.2 DMD DSP LMNA MYBPC3 MYH6 MYH7
33 cardiomyopathy, dilated, with woolly hair and keratoderma 12.1
34 cardiomyopathy, dilated, 1o 12.1
35 cardiomyopathy, dilated, 1x 12.1
36 lmna-related dilated cardiomyopathy 12.1
37 cardiomyopathy, dilated, with hypergonadotropic hypogonadism 12.0
38 3-methylglutaconic aciduria, type v 12.0
39 cardiomyopathy, dilated, 1l 11.9
40 cardiomyopathy, dilated, 1j 11.9
41 diffuse cutaneous mastocytosis 11.9
42 cardiomyopathy, dilated, 1c, with or without left ventricular noncompaction 11.9
43 cardiomyopathy, dilated, 1g 11.9
44 cardiomyopathy, dilated, 1p 11.9
45 cardiomyopathy, dilated, 1aa, with or without left ventricular noncompaction 11.9
46 cardiomyopathy, dilated, 1h 11.9
47 cardiomyopathy, dilated, 1i 11.9
48 cardiomyopathy, dilated, 1m 11.9
49 cardiomyopathy, dilated, 1w 11.9
50 cardiomyopathy, dilated, 1z 11.9

Graphical network of the top 20 diseases related to Dilated Cardiomyopathy:



Diseases related to Dilated Cardiomyopathy
Sources

Symptoms & Phenotypes for Dilated Cardiomyopathy

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MGI Mouse Phenotypes related to Dilated Cardiomyopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.16 LMNA MYBPC3 MYH6 MYH7 NKX2-5 RBM20
2 behavior/neurological MP:0005386 10.02 BAG3 DES DMD LDB3 LMNA MYBPC3
3 mortality/aging MP:0010768 9.93 TNNT2 TTN BAG3 DES DMD DSP
4 muscle MP:0005369 9.83 BAG3 DES DMD DSP LDB3 LMNA
5 respiratory system MP:0005388 9.17 BAG3 DMD LDB3 LMNA MYH6 NKX2-5
Sources

Drugs & Therapeutics for Dilated Cardiomyopathy

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Drugs for Dilated Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 144)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amlodipine Approved Phase 4 88150-42-9 2162
2
Verapamil Approved Phase 4 52-53-9 2520
3
Enalaprilat Approved Phase 4,Phase 2,Phase 3 76420-72-9 6917719
4
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
5
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
6
Enalapril Approved, Vet_approved Phase 4,Phase 2,Phase 3 75847-73-3 5362032 40466924
7
Carvedilol Approved, Investigational Phase 4,Phase 2 72956-09-3 2585
8
Angiotensin II Approved, Investigational Phase 4,Not Applicable 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
9
Doxazosin Approved Phase 4 74191-85-8 3157
10
Allopurinol Approved Phase 4,Phase 1,Phase 2 315-30-0 2094
11
Benazepril Approved, Investigational Phase 4 86541-75-5 5362124
12
Metoprolol Approved, Investigational Phase 4,Phase 2 37350-58-6, 51384-51-1 4171
13
Adenosine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 58-61-7 60961
14
Spironolactone Approved Phase 4,Phase 3,Phase 2 1952-01-7, 52-01-7 5833
15
Regadenoson Approved, Investigational Phase 4 313348-27-5 219024
16
Coenzyme Q10 Approved, Investigational, Nutraceutical Phase 4 303-98-0 5281915
17
Uric Acid Experimental, Investigational Phase 4 69-93-2 1175
18 insulin Phase 4,Not Applicable
19 calcium channel blockers Phase 4,Phase 2,Not Applicable
20 diuretics Phase 4,Phase 3,Phase 2
21
protease inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
22 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Adrenergic alpha-1 Receptor Antagonists Phase 4
24 Adrenergic alpha-Antagonists Phase 4
25 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
26 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
27 Natriuretic Agents Phase 4,Phase 3,Not Applicable
28 Sodium Chloride Symporter Inhibitors Phase 4
29 Neurotransmitter Agents Phase 4,Phase 2,Phase 1,Not Applicable
30 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
31 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2
32 Angiotensin II Type 1 Receptor Blockers Phase 4,Not Applicable
33 Angiotensin Receptor Antagonists Phase 4,Not Applicable
34 Angiotensin-Converting Enzyme Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
35 Angiotensinogen Phase 4,Not Applicable
36 Anti-Arrhythmia Agents Phase 4,Not Applicable
37 Vasodilator Agents Phase 4,Phase 3,Phase 2,Not Applicable
38 Antihypertensive Agents Phase 4,Phase 2,Phase 3,Not Applicable
39 Insulin, Globin Zinc Phase 4,Not Applicable
40 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
41 Ubiquinone Phase 4,Phase 2,Not Applicable
42 Analgesics Phase 4,Not Applicable
43 Micronutrients Phase 4,Phase 2,Not Applicable
44 Adrenergic beta-1 Receptor Antagonists Phase 4,Not Applicable
45 Natriuretic Peptide, Brain Phase 4,Not Applicable
46 Sympatholytics Phase 4,Not Applicable
47 Hormone Antagonists Phase 4,Phase 3,Not Applicable
48 Trace Elements Phase 4,Phase 2,Not Applicable
49 Hormones Phase 4,Phase 3,Not Applicable
50 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 188)
# Name Status NCT ID Phase Drugs
1 Danish ICD Study in Patients With Dilated Cardiomyopathy Unknown status NCT00542945 Phase 4
2 Therapy With Verapamil or Carvedilol in Chronic Heart Failure Unknown status NCT00374465 Phase 4 Verapamil;Carvedilol
3 Efficacy of Implantable Cardioverter Defibrillator in Patients With Non-ischemic Systolic Heart Failure on Mortality Unknown status NCT00541268 Phase 4
4 Regression of Fatty Heart by Valsartan Therapy Unknown status NCT00745953 Phase 4 Valsartan;Hydrochlorothiazide
5 Coenzyme Q10 Supplementation in Children With Idiopathic Dilated Cardiomyopathy Completed NCT02115581 Phase 4 Coenzyme Q10;Placebo
6 Supramaximal Titrated Inhibition of RAAS in Dilated Cardiomyopathy Completed NCT01917149 Phase 4 Benazepril;Valsartan;Metoprolol
7 Study of Qiliqiangxin Capsule to Treat Dilated Cardiomyopathy Completed NCT01293903 Phase 4 Qiliqiangxin capsule;Placebo
8 Effect of Beta-blockers on Structural Remodeling and Gene Expression in the Failing Human Heart Completed NCT01798992 Phase 4 Carvedilol;Metoprolol succinate;Metoprolol succinate + doxazosin
9 ACC - Atrial Contribution to CRT Completed NCT00180323 Phase 4
10 A Randomized Trial of Carvedilol in Chronic Chagas Cardiomyopathy Completed NCT01557140 Phase 4 RASi plus carvedilol
11 Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients Completed NCT00477789 Phase 4 allopurinol
12 Effects of Early Statin Treatment After Acute Myocardial Infarction (AMI) in Japanese Patients Completed NCT00128024 Phase 4 lipid-lowering treatment
13 Microvascular Dysfunction in Nonischemic Cardiomyopathy: Insights From CMR Assessment of Coronary Flow Reserve Recruiting NCT03249272 Phase 4 Regadenoson;Adenosine
14 (MitraClip in Non-Responders to Cardiac Resynchronization Therapy) Recruiting NCT02592889 Phase 4
15 Pulse Reduction On Beta-blocker and Ivabradine Therapy Recruiting NCT02973594 Phase 4 Ivabradine;Placebo
16 Effect of Aldosterone on Energy Starvation in Heart Failure Active, not recruiting NCT00574119 Phase 4 spironolactone
17 Cardiac Sarcoidosis Response To Steroids Trial Withdrawn NCT01210677 Phase 4 Prednisone
18 Orodispersible Minitablets of Enalapril in Children With Heart Failure Due to Dilated Cardiomyopathy Unknown status NCT02652728 Phase 2, Phase 3 Enalapril Orodispersible Minitablet
19 Follow-up Safety Trial in Children With Chronic Heart Failure Therapy Receiving Orodispersible Minitablets of Enalapril Unknown status NCT02654678 Phase 2, Phase 3 Enalapril Orodispersible Minitablet
20 Honey in Idiopathic Dilated Cardiomyopathy Completed NCT02987322 Phase 2, Phase 3
21 Cell Therapy In Dilated Cardiomyopathy Completed NCT00333827 Phase 3 optimal therapy for cardiaca failure
22 Autologous Transplantation of Bone Marrow Mononuclear Stem-Cells for Dilated Cardiomyopathy Completed NCT00743639 Phase 2, Phase 3
23 Repetitive Intramyocardial CD34+ Cell Therapy in Dilated Cardiomyopathy (REMEDIUM) Completed NCT02248532 Phase 2, Phase 3
24 PUFAs and Left Ventricular Function in Heart Failure Completed NCT01223703 Phase 3 n-3 PUFAs;Placebo
25 A Randomized, Controlled Study to Evaluate Algisyl-LVR™ as a Method of Left Ventricular Augmentation for Heart Failure Completed NCT01311791 Phase 2, Phase 3 Standard medical therapy
26 Effect of Rosuvastatin on Left Ventricular Remodeling Completed NCT00505154 Phase 3 Rosuvastatin;placebo
27 The Acute Effects of the Angiotensin-converting Enzyme Inhibitor Enalaprilat on Flow Distribution Completed NCT00741156 Phase 3 Enalaprilat
28 Continues Positive Airway Pressure Treatment for Patients With Dilated Cardiomyopathy and Obstructive Sleep Apnea Recruiting NCT02989181 Phase 3
29 A Study of ARRY-371797 in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation Recruiting NCT03439514 Phase 3 ARRY-371797
30 CHICAMOCHA 3 - Equivalence of Usual Interventions for Trypanosomiasis (EQUITY) Recruiting NCT02369978 Phase 2, Phase 3 Nifurtimox;Benznidazole;Placebo
31 PHOspholamban RElated CArdiomyopathy STudy - Intervention Active, not recruiting NCT01857856 Phase 3 Eplerenone
32 PREclinical Mutation CARriers From Families With DIlated Cardiomyopathy and ACE Inhibitors Terminated NCT01583114 Phase 3 perindopril;placebo
33 Cell Therapy in Chagas Cardiomyopathy Terminated NCT00349271 Phase 3 Filgrastime (G-CSF);Standart therapy
34 Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure Terminated NCT00608140 Phase 3 Optimal medical therapy (OMT)
35 A Pilot Trial of Ranolazine to Treat Patients With Dilated Cardiomyopathy Unknown status NCT02133911 Phase 2 Ranolazine
36 Intramuscular Injection of Mesenchymal Stem Cell for Treatment of Children With Idiopathic Dilated Cardiomyopathy Unknown status NCT01219452 Phase 1, Phase 2
37 Intracoronary Autologous Mesenchymal Stem Cells Implantation in Patients With Ischemic Dilated Cardiomyopathy Unknown status NCT01720888 Phase 2
38 Study of the Acute Effects of Triheptanoin in Heart Failure Unknown status NCT01787851 Phase 1, Phase 2 Triheptanoin oil
39 Use of Ixmyelocel-T (Formerly Catheter-based Cardiac Repair Cell [CRC]) Treatment in Patients With Heart Failure Due to Dilated Cardiomyopathy Completed NCT01020968 Phase 2
40 Use of Ixmyelocel-T (Formerly Cardiac Repair Cell [CRC] Treatment) in Patients With Heart Failure Due to Dilated Cardiomyopathy (IMPACT-DCM) Completed NCT00765518 Phase 2
41 Safety and Efficacy Study of Stem Cell Transplantation to Treat Dilated Cardiomyopathy Completed NCT00629018 Phase 2 Bone Marrow Stimulation
42 Safety and Efficacy Study of Intramyocardial Stem Cell Therapy in Patients With Dilated Cardiomyopathy Completed NCT01350310 Phase 2
43 Bone Marrow Derived Adult Stem Cells for Dilated Cardiomyopathy Completed NCT01302171 Phase 2 granulocyte colony stimulating factor (GCSF)
44 Intracoronary Infusion of Autologous Bone Marrow Cells for Treatment of Idiopathic Dilated Cardiomyopathy Completed NCT00629096 Phase 2
45 PercutaneOus StEm Cell Injection Delivery Effects On Neomyogenesis in Dilated CardioMyopathy (The POSEIDON-DCM Study) Completed NCT01392625 Phase 1, Phase 2
46 Autologous Transplantation of Bone Marrow Mononuclear Stem-Cells by Mini-Thoracotomy Completed NCT00615394 Phase 1, Phase 2
47 Safety and Feasibility of Algisyl-LVR™ as a Method of Left Ventricular Restoration in Patients With DCM Undergoing Open-heart Surgery Completed NCT00847964 Phase 2
48 A Study of ARRY-371797 in Patients With LMNA-Related Dilated Cardiomyopathy Completed NCT02057341 Phase 2 ARRY-371797, p38 inhibitor; oral
49 Intracoronary Transplantation of Bone Marrow Derived Mononuclear Cells in Pediatric Cardiomyopathy Completed NCT02256501 Phase 1, Phase 2
50 Randomized Clinical Trial of Intravenous Infusion Umbilical Cord Mesenchymal Stem Cells on Cardiopathy Completed NCT01739777 Phase 1, Phase 2

Search NIH Clinical Center for Dilated Cardiomyopathy

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Dilated Cardiomyopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Dilated Cardiomyopathy:
Autologous bone marrow-derived stem cells for treatment of dilated cardiomyopathy
Bone marrow-derived hematopoietic stem cells for treatment of pediatric dilated cardiomyopathy
Bone marrow-derived mesenchymal stem cells for treatment of heart diseases
Bone marrow-derived mononuclear cells for myocardial infarction
Enriched bone marrow-derived progenitor cells for heart diseases
Ixmyelocel-T, mesenchymal stem cells and monocytes for dilated cardiomyopathy
Peripheral blood-derived CD34+ stem cells for treatment of dilated cardiomyopathy
Umbilical cord-derived mesenchymal stem cells for treatment of dilated cardiomyopathy
Embryonic/Adult Cultured Cells Related to Dilated Cardiomyopathy:
Bone marrow-derived mononuclear cells
Bone marrow-derived hematopoietic stem cells (family)
Bone marrow-derived mesenchymal stem cells PMIDs: 22940024
Bone marrow-derived mononuclear cells PMIDs: 22834565
Bone marrow-derived mononuclear cells PMIDs: 22834565
Bone marrow-derived progenitor cells PMIDs: 23362308 22936827 18794392 16990384 16990385 22651868
Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T) PMIDs: 22776246 22453769
Peripheral blood-derived CD34+ cells PMIDs: 23065358
Umbilical cord-derived mesenchymal stem cells (family)

Cochrane evidence based reviews: cardiomyopathy, dilated

Sources

Genetic Tests for Dilated Cardiomyopathy

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Genetic tests related to Dilated Cardiomyopathy:

# Genetic test Affiliating Genes
1 Primary Dilated Cardiomyopathy 29 ABCC9 ACTC1 ACTN2 ANKRD1 BAG3 CSRP3 DES DSG2 EYA4 FKTN LDB3 LMNA MYBPC3 MYH6 NEXN PLN PSEN1 PSEN2 RBM20 SGCD TAZ TCAP TMPO TNNT2 TPM1 TTN VCL
2 Familial Dilated Cardiomyopathy 29
3 Dilated Cardiomyopathy 29
Sources

Anatomical Context for Dilated Cardiomyopathy

About this section

MalaCards organs/tissues related to Dilated Cardiomyopathy:

41
Heart, Bone, Bone Marrow, Endothelial, Testes, Brain, Monocytes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Dilated Cardiomyopathy:
# Tissue Anatomical CompartmentCell Relevance
1 Heart Myocardium Cardiomyocytes Affected by disease
2 Heart Left Ventricle Cardiomyocytes Potential therapeutic candidate, affected by disease
3 Blood Cord Blood Mesenchymal Stem Cells Potential therapeutic candidate
4 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate
Sources

Publications for Dilated Cardiomyopathy

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Articles related to Dilated Cardiomyopathy:

(show top 50) (show all 2114)
# Title Authors Year
1
Genome sequencing as a first-line genetic test in familial dilated cardiomyopathy. ( 29961767 )
2018
2
Prognostic value of myocardial strain and late gadolinium enhancement on cardiovascular magnetic resonance imaging in patients with idiopathic dilated cardiomyopathy with moderate to severely reduced ejection fraction. ( 29898740 )
2018
3
Whole exome sequencing identifies a novel mutation (c.333a8^+a8^2Ta8^>a8^C) of TNNI3K in a Chinese family with dilated cardiomyopathy and cardiac conduction disease. ( 29355681 )
2018
4
Addition of Digoxin Improves Cardiac Function in Children With the Dilated Cardiomyopathy With Ataxia Syndrome: AA Mitochondrial Cardiomyopathy. ( 29887217 )
2018
5
Advanced Dilated Cardiomyopathy in a Patient With Hutterite Limb-Girdle Muscular Dystrophy: Use of a Left Ventricular Assist Device. ( 29626101 )
2018
6
Identification of cardiac long non-coding RNA profile in human dilated cardiomyopathy. ( 29365080 )
2018
7
Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation. ( 29878125 )
2018
8
A novel DMD splicing mutation found in a family responsible for X-linked dilated cardiomyopathy with hyper-CKemia. ( 29901616 )
2018
9
A morpho-functional study using PEP/LVET ratio and global longitudinal strain in patients with dilated cardiomyopathy. ( 29940616 )
2018
10
Correlations of GDF-15 with sST2, MMPs, and worsening functional capacity in idiopathic dilated cardiomyopathy: Can we gain new insights into the pathophysiology? ( 29375722 )
2018
11
Ion Channel Dysfunctions in Dilated Cardiomyopathy in Limb-Girdle Muscular Dystrophy. ( 29545480 )
2018
12
Cardiac specific expression of a88H2-R15 mini-dystrophin normalized all ECG abnormalities and the end-diastolic volume in a 23-m-old mouse model of Duchenne dilated cardiomyopathy. ( 29433343 )
2018
13
Sarcomeric Auto-Oscillations in Single Myofibrils From the Heart of Patients With Dilated Cardiomyopathy. ( 29980594 )
2018
14
Cardiac Nestin<sup>+</sup>Cells Derived from Early Stage of Dilated Cardiomyopathy Enhanced the Survival of the Doxorubicin-Injured Cardiac Muscle HL-1 Cells. ( 29375111 )
2018
15
ZBTB17 loss-of-function mutation contributes to familial dilated cardiomyopathy. ( 29445930 )
2018
16
Efficacy of cardiac resynchronization therapy in patients with isolated ventricular noncompaction with dilated cardiomyopathy: a systematic review of the literature. ( 29877973 )
2018
17
Is there a role for tissue Doppler imaging in predicting thromboembolic risk? A challenging case report of dilated cardiomyopathy with intracardiac thrombus and recurrent stroke. ( 29894356 )
2018
18
A Case of dilated Cardiomyopathy with Eosinophilic Granulomatosis with Polyangiitis in which Active Myocardial Inflammation was Only Detected by Endomyocardial Biopsy. ( 29709930 )
2018
19
Torsion Mechanics as an Indicator of More Advanced Left Ventricular Systolic Dysfunction in Secondary Mitral Regurgitation in Patients with Dilated Cardiomyopathy: A 2D Speckle-Tracking Analysis. ( 29408823 )
2018
20
Clinical Course and Treatment of Dilated Cardiomyopathy During Twenty Years of Follow-up. ( 29416222 )
2018
21
A novel splicing variant in FLNC gene responsible for a highly penetrant familial dilated cardiomyopathy in an extended Iranian family. ( 29551499 )
2018
22
Contractile reserve as a predictor of prognosis in patients with non-ischaemic systolic heart failure and dilated cardiomyopathy: a systematic review and meta-analysis. ( 29258998 )
2018
23
Pompe disease treatment with twice a week high dose alglucoside alfa in a patient with severe dilated cardiomyopathy. ( 29946513 )
2018
24
Effects of Repetitive Transendocardial CD34<sup>+</sup> Cell Transplantation in Patients with Non-Ischemic Dilated Cardiomyopathy. ( 29880546 )
2018
25
Fast apixaban-related resolution of left ventricular thrombi in a patient with dilated cardiomyopathy. ( 29374418 )
2018
26
No Obesity Paradox in Pediatric Patients With Dilated Cardiomyopathy. ( 29428438 )
2018
27
Two-year cardiac mortality after MitraClip treatment of functional mitral regurgitation in ischemic and non-ischemic dilated cardiomyopathy. ( 29929931 )
2018
28
Inherited dilated cardiomyopathy in a large Moroccan family caused by LMNA mutation. ( 29952368 )
2018
29
Dilated cardiomyopathy with re-worsening left ventricular ejection fraction. ( 29942977 )
2018
30
CD34<sup>+</sup>Cell Transplantation Improves Right Ventricular Function in Patients with Nonischemic Dilated Cardiomyopathy. ( 29380563 )
2018
31
Identification of new biophysical markers for pathological ventricular remodelling in tachycardia-induced dilated cardiomyopathy. ( 29921039 )
2018
32
Atypical Presentation of a Large Pericardial Effusion after Heart Transplantation in a Patient with Dilated Cardiomyopathy. ( 29429930 )
2018
33
Dilated cardiomyopathy complicated with visceral heterotaxy. ( 29040450 )
2018
34
A new phenotype of severe dilated cardiomyopathy associated with a mutation in the LAMP2 gene previously known to cause hypertrophic cardiomyopathy in the context of Danon disease. ( 29753918 )
2018
35
Dilated Cardiomyopathy in a Child with Recessive Dystrophic Epidermolysis Bullosa. ( 29699768 )
2018
36
Myocardium of patients with dilated cardiomyopathy presents altered expression of genes involved in thyroid hormone biosynthesis. ( 29320567 )
2018
37
Pediatric Dilated Cardiomyopathy-Associated<i>LRRC10</i>(Leucine-Rich Repeat-Containing 10) Variant Reveals LRRC10 as an Auxiliary Subunit of Cardiac L-Type Ca<sup>2+</sup>Channels. ( 29431102 )
2018
38
Potential for and timing of recovery in children with dilated cardiomyopathy. ( 29887441 )
2018
39
Late restored cardiac function after successful resynchronization by right posterior accessory pathway ablation in Wolff-Parkinson-White syndrome associated dilated cardiomyopathy. ( 29452709 )
2018
40
GDF-15 is a better complimentary marker for risk stratification of arrhythmic death in non-ischaemic, dilated cardiomyopathy than soluble ST2. ( 29397580 )
2018
41
A gene-centric strategy for identifying disease-causing rare variants in dilated cardiomyopathy. ( 29892087 )
2018
42
Identifying Non-invasive Tools to Distinguish Acute Myocarditis from Dilated Cardiomyopathy in Children. ( 29651540 )
2018
43
Influence of LGALS3 gene polymorphisms on susceptibility and prognosis of dilated cardiomyopathy in a Northern Han Chinese population. ( 29129812 )
2018
44
X-Linked Dilated Cardiomyopathy Presenting as Acute Rhabdomyolysis and Presumed Epstein-Barr Virus-Induced Viral Myocarditis: A Case Report. ( 29891833 )
2018
45
Cardiac Amyloidosis Mimicking Dilated Cardiomyopathy But Showing Relative Apical Sparing of Longitudinal Strain. ( 29877202 )
2018
46
Rare genetic mutations in Pakistani patients with dilated cardiomyopathy. ( 29886034 )
2018
47
The pathogenic gene screening in a Chinese familial dilated cardiomyopathy pedigree from Hubei. ( 29109008 )
2018
48
The relationship between myocardial fibrosis and myocardial microRNAs in dilated cardiomyopathy: A link between mir-133a and cardiovascular events. ( 29377565 )
2018
49
Insights from Second-Line Treatments for Idiopathic Dilated Cardiomyopathy. ( 29367542 )
2017
50
Response Gene to Complement-32 Promotes the Imbalance of Treg/Th17 in Patients with Dilated Cardiomyopathy. ( 29035886 )
2017
Sources

Variations for Dilated Cardiomyopathy

About this section

ClinVar genetic disease variations for Dilated Cardiomyopathy:

6
(show top 50) (show all 1658)
# Gene Variation Type Significance SNP ID Assembly Location
1 RBM20 NM_001134363.2(RBM20): c.1913C> T (p.Pro638Leu) single nucleotide variant Pathogenic rs267607003 GRCh37 Chromosome 10, 112572068: 112572068
2 RBM20 NM_001134363.2(RBM20): c.1913C> T (p.Pro638Leu) single nucleotide variant Pathogenic rs267607003 GRCh38 Chromosome 10, 110812310: 110812310
3 RBM20 NM_001134363.2(RBM20): c.1906C> A (p.Arg636Ser) single nucleotide variant Pathogenic/Likely pathogenic rs267607002 GRCh37 Chromosome 10, 112572061: 112572061
4 RBM20 NM_001134363.2(RBM20): c.1906C> A (p.Arg636Ser) single nucleotide variant Pathogenic/Likely pathogenic rs267607002 GRCh38 Chromosome 10, 110812303: 110812303
5 RBM20 NM_001134363.2(RBM20): c.1907G> A (p.Arg636His) single nucleotide variant Pathogenic/Likely pathogenic rs267607004 GRCh37 Chromosome 10, 112572062: 112572062
6 RBM20 NM_001134363.2(RBM20): c.1907G> A (p.Arg636His) single nucleotide variant Pathogenic/Likely pathogenic rs267607004 GRCh38 Chromosome 10, 110812304: 110812304
7 LDB3 NM_001080114.1(LDB3): c.494C> T (p.Ala165Val) single nucleotide variant Pathogenic rs121908334 GRCh37 Chromosome 10, 88446975: 88446975
8 LDB3 NM_001080114.1(LDB3): c.494C> T (p.Ala165Val) single nucleotide variant Pathogenic rs121908334 GRCh38 Chromosome 10, 86687218: 86687218
9 TCAP NM_003673.3(TCAP): c.157C> T (p.Gln53Ter) single nucleotide variant Likely pathogenic rs104894655 GRCh37 Chromosome 17, 37822015: 37822015
10 TCAP NM_003673.3(TCAP): c.157C> T (p.Gln53Ter) single nucleotide variant Likely pathogenic rs104894655 GRCh38 Chromosome 17, 39665762: 39665762
11 MYBPC3 NM_000256.3(MYBPC3): c.1624G> C (p.Glu542Gln) single nucleotide variant Pathogenic/Likely pathogenic rs121909374 GRCh37 Chromosome 11, 47364129: 47364129
12 MYBPC3 NM_000256.3(MYBPC3): c.1624G> C (p.Glu542Gln) single nucleotide variant Pathogenic/Likely pathogenic rs121909374 GRCh38 Chromosome 11, 47342578: 47342578
13 SCN5A NM_000335.4(SCN5A): c.4780G> C (p.Asp1594His) single nucleotide variant Pathogenic rs137854607 GRCh37 Chromosome 3, 38595800: 38595800
14 SCN5A NM_000335.4(SCN5A): c.4780G> C (p.Asp1594His) single nucleotide variant Pathogenic rs137854607 GRCh38 Chromosome 3, 38554309: 38554309
15 TNNT2 NM_001001430.2(TNNT2): c.421C> T (p.Arg141Trp) single nucleotide variant Pathogenic/Likely pathogenic rs74315379 GRCh37 Chromosome 1, 201333464: 201333464
16 TNNT2 NM_001001430.2(TNNT2): c.421C> T (p.Arg141Trp) single nucleotide variant Pathogenic/Likely pathogenic rs74315379 GRCh38 Chromosome 1, 201364336: 201364336
17 TNNT2 NM_001001430.2(TNNT2): c.391C> T (p.Arg131Trp) single nucleotide variant Pathogenic/Likely pathogenic rs74315380 GRCh37 Chromosome 1, 201333494: 201333494
18 TNNT2 NM_001001430.2(TNNT2): c.391C> T (p.Arg131Trp) single nucleotide variant Pathogenic/Likely pathogenic rs74315380 GRCh38 Chromosome 1, 201364366: 201364366
19 TTN NM_001256850.1(TTN): c.2926T> C (p.Trp976Arg) single nucleotide variant Pathogenic rs267607155 GRCh37 Chromosome 2, 179647707: 179647707
20 TTN NM_001256850.1(TTN): c.2926T> C (p.Trp976Arg) single nucleotide variant Pathogenic rs267607155 GRCh38 Chromosome 2, 178782980: 178782980
21 PLN NM_002667.4(PLN): c.25C> T (p.Arg9Cys) single nucleotide variant Pathogenic rs111033559 GRCh37 Chromosome 6, 118880109: 118880109
22 PLN NM_002667.4(PLN): c.25C> T (p.Arg9Cys) single nucleotide variant Pathogenic rs111033559 GRCh38 Chromosome 6, 118558946: 118558946
23 PLN NM_002667.4(PLN): c.116T> G (p.Leu39Ter) single nucleotide variant Pathogenic rs111033560 GRCh37 Chromosome 6, 118880200: 118880200
24 PLN NM_002667.4(PLN): c.116T> G (p.Leu39Ter) single nucleotide variant Pathogenic rs111033560 GRCh38 Chromosome 6, 118559037: 118559037
25 MYH7 NM_000257.3(MYH7): c.1594T> C (p.Ser532Pro) single nucleotide variant Pathogenic rs121913642 GRCh37 Chromosome 14, 23897088: 23897088
26 MYH7 NM_000257.3(MYH7): c.1594T> C (p.Ser532Pro) single nucleotide variant Pathogenic rs121913642 GRCh38 Chromosome 14, 23427879: 23427879
27 MYH7 NM_000257.3(MYH7): c.732+1G> A single nucleotide variant Pathogenic/Likely pathogenic rs730880850 GRCh38 Chromosome 14, 23431584: 23431584
28 MYH7 NM_000257.3(MYH7): c.732+1G> A single nucleotide variant Pathogenic/Likely pathogenic rs730880850 GRCh37 Chromosome 14, 23900793: 23900793
29 LMNA NM_170707.3(LMNA): c.16C> T (p.Gln6Ter) single nucleotide variant Pathogenic rs61046466 GRCh37 Chromosome 1, 156084725: 156084725
30 LMNA NM_170707.3(LMNA): c.16C> T (p.Gln6Ter) single nucleotide variant Pathogenic rs61046466 GRCh38 Chromosome 1, 156114934: 156114934
31 LMNA NM_170707.3(LMNA): c.585C> G (p.Asn195Lys) single nucleotide variant Pathogenic rs28933091 GRCh37 Chromosome 1, 156104265: 156104265
32 LMNA NM_170707.3(LMNA): c.585C> G (p.Asn195Lys) single nucleotide variant Pathogenic rs28933091 GRCh38 Chromosome 1, 156134474: 156134474
33 LMNA NM_170707.3(LMNA): c.608A> G (p.Glu203Gly) single nucleotide variant Pathogenic rs28933092 GRCh37 Chromosome 1, 156104288: 156104288
34 LMNA NM_170707.3(LMNA): c.608A> G (p.Glu203Gly) single nucleotide variant Pathogenic rs28933092 GRCh38 Chromosome 1, 156134497: 156134497
35 LMNA NM_170707.3(LMNA): c.481G> A (p.Glu161Lys) single nucleotide variant Pathogenic rs28933093 GRCh37 Chromosome 1, 156100532: 156100532
36 LMNA NM_170707.3(LMNA): c.481G> A (p.Glu161Lys) single nucleotide variant Pathogenic rs28933093 GRCh38 Chromosome 1, 156130741: 156130741
37 DSP NM_004415.3(DSP): c.3799C> T (p.Arg1267Ter) single nucleotide variant Likely pathogenic rs121912997 GRCh37 Chromosome 6, 7580222: 7580222
38 DSP NM_004415.3(DSP): c.3799C> T (p.Arg1267Ter) single nucleotide variant Likely pathogenic rs121912997 GRCh38 Chromosome 6, 7579989: 7579989
39 BAG3 NM_004281.3(BAG3): c.367C> T (p.Arg123Ter) single nucleotide variant Pathogenic/Likely pathogenic rs387906875 GRCh37 Chromosome 10, 121429549: 121429549
40 BAG3 NM_004281.3(BAG3): c.367C> T (p.Arg123Ter) single nucleotide variant Pathogenic/Likely pathogenic rs387906875 GRCh38 Chromosome 10, 119670037: 119670037
41 MYPN NM_032578.3(MYPN): c.458A> G (p.Lys153Arg) single nucleotide variant Likely pathogenic rs199476401 GRCh37 Chromosome 10, 69881653: 69881653
42 MYPN NM_032578.3(MYPN): c.458A> G (p.Lys153Arg) single nucleotide variant Likely pathogenic rs199476401 GRCh38 Chromosome 10, 68121896: 68121896
43 TPM1 NM_001018005.1(TPM1): c.688G> A (p.Asp230Asn) single nucleotide variant Pathogenic rs199476317 GRCh37 Chromosome 15, 63354462: 63354462
44 TPM1 NM_001018005.1(TPM1): c.688G> A (p.Asp230Asn) single nucleotide variant Pathogenic rs199476317 GRCh38 Chromosome 15, 63062263: 63062263
45 TPM1 NM_001018005.1(TPM1): c.275T> C (p.Ile92Thr) single nucleotide variant Likely pathogenic rs199476310 GRCh37 Chromosome 15, 63349218: 63349218
46 TPM1 NM_001018005.1(TPM1): c.275T> C (p.Ile92Thr) single nucleotide variant Likely pathogenic rs199476310 GRCh38 Chromosome 15, 63057019: 63057019
47 LMNA NM_005572.3(LMNA): c.1003C> T (p.Arg335Trp) single nucleotide variant Pathogenic/Likely pathogenic rs386134243 GRCh37 Chromosome 1, 156105758: 156105758
48 LMNA NM_005572.3(LMNA): c.1003C> T (p.Arg335Trp) single nucleotide variant Pathogenic/Likely pathogenic rs386134243 GRCh38 Chromosome 1, 156135967: 156135967
49 SCN5A NM_198056.2(SCN5A): c.665G> A (p.Arg222Gln) single nucleotide variant Pathogenic rs45546039 GRCh37 Chromosome 3, 38655272: 38655272
50 SCN5A NM_198056.2(SCN5A): c.665G> A (p.Arg222Gln) single nucleotide variant Pathogenic rs45546039 GRCh38 Chromosome 3, 38613781: 38613781
Sources

Expression for Dilated Cardiomyopathy

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Search GEO for disease gene expression data for Dilated Cardiomyopathy.
Sources

Pathways for Dilated Cardiomyopathy

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Pathways related to Dilated Cardiomyopathy according to KEGG:

37
# Name Kegg Source Accession
1 Dilated cardiomyopathy (DCM) hsa05414

Pathways related to Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 37
Show member pathways
 12.81 MYH6 MYH7 PLN SCN5A TNNI3 TNNT2
2
Cardiac conduction 66
Show member pathways
 12.62 DES DMD MYBPC3 MYH6 NKX2-5 PLN
3
Cytoskeletal Signaling 4
12.32 DES LMNA TNNI3 TNNT2 TPM1
4
Arrhythmogenic right ventricular cardiomyopathy (ARVC) 37
Show member pathways
 12.16 DES DMD DSP LMNA
5
Cardiac muscle contraction 37
11.61 MYH6 MYH7 TNNI3 TNNT2 TPM1
6
Dilated cardiomyopathy (DCM) 37
Show member pathways
 11.6 DES DMD LMNA MYBPC3 MYH6 MYH7
7
Antiarrhythmic Pathway, Pharmacodynamics 61
11.42 DSP LMNA PLN SCN5A
8
Striated Muscle Contraction 1 66
11.42 DES DMD MYBPC3 MYH6 TNNI3 TNNT2
9
Cardiac Progenitor Differentiation 1
11.38 MYH6 NKX2-5 SCN5A TNNI3 TNNT2
10
Cardiomyocyte Differentiation through BMP Receptors 64
10.82 MYH7 NKX2-5
Sources

GO Terms for Dilated Cardiomyopathy

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Cellular components related to Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 sarcolemma GO:0042383 9.7 DES DMD SCN5A
2 stress fiber GO:0001725 9.65 MYH6 MYH7 TPM1
3 intercalated disc GO:0014704 9.63 DES DSP SCN5A
4 sarcomere GO:0030017 9.63 MYBPC3 MYH6 MYH7 TNNI3 TNNT2 TPM1
5 muscle myosin complex GO:0005859 9.62 MYBPC3 MYH6 MYH7 TTN
6 striated muscle thin filament GO:0005865 9.58 MYBPC3 TNNT2 TTN
7 cardiac myofibril GO:0097512 9.56 DES MYBPC3 TNNI3 TNNT2
8 contractile fiber GO:0043292 9.54 DES TNNI3
9 myosin filament GO:0032982 9.54 MYBPC3 MYH6 MYH7
10 fascia adherens GO:0005916 9.51 DES DSP
11 troponin complex GO:0005861 9.49 TNNI3 TNNT2
12 cardiac Troponin complex GO:1990584 9.43 TNNI3 TNNT2
13 myofibril GO:0030016 9.43 DMD MYH6 MYH7 TNNI3 TNNT2 TPM1
14 Z disc GO:0030018 9.28 BAG3 DES DMD LDB3 MYBPC3 MYH6

Biological processes related to Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.9 NKX2-5 RBM20 TAZ TNNI3
2 muscle contraction GO:0006936 9.86 DES MYH6 MYH7 TAZ TNNI3 TNNT2
3 actin filament organization GO:0007015 9.82 MYBPC3 TPM1 TTN
4 regulation of heart contraction GO:0008016 9.8 DES MYH6 PLN TNNT2 TPM1
5 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.8 MYBPC3 MYH6 MYH7 TNNI3 TNNT2 TPM1
6 striated muscle contraction GO:0006941 9.77 MYBPC3 MYH6 MYH7 TNNI3 TTN
7 regulation of cardiac conduction GO:1903779 9.73 NKX2-5 PLN TNNI3
8 regulation of heart rate GO:0002027 9.73 DMD MYH6 MYH7 SCN5A
9 positive regulation of ATPase activity GO:0032781 9.72 MYBPC3 TNNT2 TPM1
10 skeletal muscle contraction GO:0003009 9.71 MYH7 TNNI3 TNNT2
11 cardiac muscle tissue development GO:0048738 9.7 NKX2-5 PLN TAZ
12 sarcomere organization GO:0045214 9.7 LDB3 MYBPC3 MYH6 NKX2-5 TNNT2 TPM1
13 cardiac muscle contraction GO:0060048 9.7 DMD MYBPC3 MYH6 MYH7 NKX2-5 SCN5A
14 regulation of the force of heart contraction GO:0002026 9.69 MYH6 MYH7 PLN
15 regulation of muscle contraction GO:0006937 9.67 TNNI3 TNNT2 TPM1
16 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.65 DMD PLN
17 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.65 DMD PLN
18 adult heart development GO:0007512 9.65 MYH6 MYH7 NKX2-5
19 intermediate filament organization GO:0045109 9.64 DES DSP
20 cardiac muscle tissue morphogenesis GO:0055008 9.64 NKX2-5 TTN
21 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.63 DMD PLN
22 positive regulation of sodium ion transport GO:0010765 9.63 NKX2-5 SCN5A
23 negative regulation of ATPase activity GO:0032780 9.63 PLN TNNI3 TNNT2
24 cardiac muscle hypertrophy in response to stress GO:0014898 9.62 MYH6 MYH7
25 heart contraction GO:0060047 9.62 NKX2-5 TNNI3
26 cardiac muscle fiber development GO:0048739 9.61 MYH6 TTN
27 regulation of cardiac muscle cell contraction GO:0086004 9.61 PLN SCN5A
28 ventricular cardiac muscle cell development GO:0055015 9.59 LMNA NKX2-5
29 response to denervation involved in regulation of muscle adaptation GO:0014894 9.58 DMD SCN5A
30 striated muscle myosin thick filament assembly GO:0071688 9.58 MYBPC3 TTN
31 transition between fast and slow fiber GO:0014883 9.57 MIR499A MYH7
32 muscle filament sliding GO:0030049 9.28 DES DMD MYBPC3 MYH6 MYH7 TNNI3

Molecular functions related to Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 calmodulin binding GO:0005516 9.71 MYH6 MYH7 SCN5A TTN
2 cytoskeletal protein binding GO:0008092 9.65 DES LDB3 TPM1
3 structural constituent of cytoskeleton GO:0005200 9.62 DES DMD DSP TPM1
4 microfilament motor activity GO:0000146 9.51 MYH6 MYH7
5 actin binding GO:0003779 9.5 DMD MYBPC3 MYH6 MYH7 TNNI3 TNNT2
6 nitric-oxide synthase binding GO:0050998 9.49 DMD SCN5A
7 structural molecule activity conferring elasticity GO:0097493 9.46 MYBPC3 TTN
8 structural constituent of muscle GO:0008307 9.46 DMD MYBPC3 TPM1 TTN
9 actin-dependent ATPase activity GO:0030898 9.43 MYH6 MYH7
10 muscle alpha-actinin binding GO:0051371 9.43 LDB3 MYBPC3 TTN
11 troponin C binding GO:0030172 9.37 TNNI3 TNNT2
12 actin filament binding GO:0051015 9.1 MYBPC3 MYH6 MYH7 TNNI3 TPM1 TTN
Sources

Sources for Dilated Cardiomyopathy

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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