DCM
MCID: DLT002
MIFTS: 74

Dilated Cardiomyopathy (DCM)

Categories: Blood diseases, Cardiovascular diseases, Ear diseases, Genetic diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Dilated Cardiomyopathy

MalaCards integrated aliases for Dilated Cardiomyopathy:

Name: Dilated Cardiomyopathy 38 12 76 24 53 37 29 55 6 15
Familial Dilated Cardiomyopathy 12 76 53 25 29 6 73
Idiopathic Dilation Cardiomyopathy 12 76 73
Primary Dilated Cardiomyopathy 12 29 6
Cardiomyopathy, Dilated 44 40 73
Congestive Cardiomyopathy 12 25
Dcm 53 48
Hypokinetic Dilated Cardiomyopathy, Familial 53
Primary Familial Dilated Cardiomyopathy 25
Cardiomyopathy, Familial Idiopathic 73
Familial Idiopathic Cardiomyopathy 25
Idiopathic Dilated Cardiomyopathy 53
Cardiomyopathy, Familial Dilated 53
Dilated Cardiomyopathy, Familial 53
Fdc 25

Classifications:



External Ids:

Disease Ontology 12 DOID:12930
ICD10 33 I42.0
MeSH 44 D002311
NCIt 50 C84673
SNOMED-CT 68 74368002
KEGG 37 H00294

Summaries for Dilated Cardiomyopathy

NIH Rare Diseases : 53 Dilated cardiomyopathy (DCM) is a disease of the heart muscle which primarily affects the heart's main pumping chamber, the left ventricle. It is the most common type of cardiomyopathy and typically affects those aged 20 to 60. The left ventricle of affected individuals becomes enlarged (dilated) and cannot pump blood to the body with as much force as a healthy heart can. The heart muscle also has difficulty contracting normally, which can lead to irregular heartbeats (arrhythmia), blood clots, or sudden death. Over time, the heart becomes weaker and heart failure can occur. While the cause of dilated cardiomyopathy is often unknown (idiopathic), some cases are acquired and roughly half are inherited or familial. Also, DCM can be a feature of many genetic syndromes. Familial dilated cardiomyopathy is most often inherited in an autosomal dominant pattern. Familial dilated cardiomyopathy is caused by mutations in several different genes, most commonly in the TTN gene (found in about 20% of cases). DCM treatment may include medication, pacemakers, implantable cardiac defibrillators, or heart transplantation. 

MalaCards based summary : Dilated Cardiomyopathy, also known as familial dilated cardiomyopathy, is related to familial isolated dilated cardiomyopathy and ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy. An important gene associated with Dilated Cardiomyopathy is LMNA (Lamin A/C), and among its related pathways/superpathways are Dilated cardiomyopathy (DCM) and Cardiac conduction. The drugs Carvedilol and Verapamil have been mentioned in the context of this disorder. Affiliated tissues include Heart and Heart, and related phenotypes are cardiovascular system and mortality/aging

Disease Ontology : 12 An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently.

Wikipedia : 76 Dilated cardiomyopathy (DCM) is a condition in which the heart becomes enlarged and cannot pump blood... more...

GeneReviews: NBK1309

Related Diseases for Dilated Cardiomyopathy

Diseases in the Dilated Cardiomyopathy family:

Cardiomyopathy, Dilated, 1a Cardiomyopathy, Dilated, 3b
Cardiomyopathy, Dilated, 1b Cardiomyopathy, Dilated, 1e
Cardiomyopathy, Dilated, 1d Cardiomyopathy, Dilated, 1g
Cardiomyopathy, Dilated, 1h Cardiomyopathy, Dilated, 1i
Cardiomyopathy, Dilated, 1j Cardiomyopathy, Dilated, 1k
Cardiomyopathy, Dilated, 1l Cardiomyopathy, Dilated, 1m
Cardiomyopathy, Dilated, 1o Cardiomyopathy, Dilated, 1p
Cardiomyopathy, Dilated, 1q Cardiomyopathy, Dilated, 1w
Cardiomyopathy, Dilated, 1x Cardiomyopathy, Dilated, 1z
Cardiomyopathy, Dilated, 2a Cardiomyopathy, Dilated, 1bb
Cardiomyopathy, Dilated, 1cc Cardiomyopathy, Dilated, 1dd
Cardiomyopathy, Dilated, 1ee Cardiomyopathy, Dilated, 1ff
Cardiomyopathy, Dilated, 1r Cardiomyopathy, Dilated, 1gg
Cardiomyopathy, Dilated, 1u Cardiomyopathy, Dilated, 1v
Cardiomyopathy, Dilated, 1hh Cardiomyopathy, Dilated, 2b
Cardiomyopathy, Dilated, 1ii Cardiomyopathy, Dilated, 1jj
Cardiomyopathy, Dilated, 1kk Cardiomyopathy, Dilated, 1nn
Autoimmune Cardiomyopathy Dilated Cardiomyopathy 1t
Lmna-Related Dilated Cardiomyopathy Cardiomyopathy Due to Anthracyclines

Diseases related to Dilated Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 438)
# Related Disease Score Top Affiliating Genes
1 familial isolated dilated cardiomyopathy 34.7 BAG3 CSRP3 DES DMD DSG2 LDB3
2 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 34.3 DSG2 DSP MYH7 SCN5A
3 cardiomyopathy, dilated, 1e 34.3 DES DSP LMNA MYH7 NKX2-5 RBM20
4 cardiomyopathy, dilated, 1b 34.0 DMD LDB3
5 cardiomyopathy, dilated, 1a 33.7 DMD LDB3 LMNA
6 cardiomyopathy, dilated, 1d 33.7 DMD LDB3 TNNT2
7 muscular dystrophy, congenital, 1b 33.1 DMD LDB3
8 myocarditis 32.9 DMD DSP TNNI3
9 congenital fiber-type disproportion 32.7 DMD LMNA MYH7
10 peripartum cardiomyopathy 32.7 MYH7 TTN
11 campomelic dysplasia 32.5 BAG3 LMNA MYBPC3 RBM20 TTN
12 myopathy, myofibrillar, 1 32.4 DES LDB3
13 hypertrophic cardiomyopathy 31.6 CSRP3 DES DSP LDB3 LMNA MYBPC3
14 cardiac conduction defect 31.5 DSP LMNA MYBPC3 MYH7 PLN SCN5A
15 myopathy 31.4 DES LDB3 MYH7 TTN
16 heart disease 31.4 DSP LMNA MIR196A2 MYBPC3 MYH7 NKX2-5
17 left ventricular noncompaction 31.2 BAG3 CSRP3 DES DMD DSP LDB3
18 arrhythmogenic right ventricular cardiomyopathy 31.2 DES DMD DSG2 DSP LDB3 LMNA
19 atrioventricular block 31.2 LMNA NKX2-5 SCN5A
20 wolff-parkinson-white syndrome 31.1 MYH7 NKX2-5 TNNI3
21 atrial standstill 1 30.9 CSRP3 DES DMD DSG2 DSP LMNA
22 endocardial fibroelastosis 30.8 CSRP3 MYH7
23 restrictive cardiomyopathy 30.7 DES MYBPC3 MYH7 TNNI3 TNNT2 TPM1
24 cardiac arrest 30.7 DSP MYBPC3 MYH7 PLN SCN5A TNNT2
25 ventricular fibrillation, paroxysmal familial, 1 30.6 DSP NKX2-5 SCN5A TNNT2
26 atrial heart septal defect 30.5 DMD NKX2-5 TNNI3
27 sick sinus syndrome 30.4 LMNA SCN5A TTN
28 aortic valve disease 1 30.3 DSP NKX2-5 TNNI3
29 acute myocardial infarction 30.1 MIR499A TNNI3 TNNT2
30 dilated cardiomyopathy 1t 12.5
31 cardiac conduction disease with or without dilated cardiomyopathy 12.5
32 cardiomyopathy, dilated, 3b 12.5
33 cardiomyopathy, dilated, with woolly hair and keratoderma 12.3
34 cardiomyopathy, dilated, 1o 12.2
35 cardiomyopathy, dilated, 1x 12.2
36 lmna-related dilated cardiomyopathy 12.2
37 cardiomyopathy, dilated, with hypergonadotropic hypogonadism 12.2
38 3-methylglutaconic aciduria, type v 12.2
39 cardiomyopathy, dilated, 1l 12.1
40 cardiomyopathy, dilated, 1c, with or without left ventricular noncompaction 12.1
41 cardiomyopathy, dilated, 1j 12.1
42 cardiomyopathy, dilated, 1g 12.1
43 cardiomyopathy, dilated, 1p 12.1
44 cardiomyopathy, dilated, 1aa, with or without left ventricular noncompaction 12.1
45 cardiomyopathy, dilated, 1h 12.0
46 cardiomyopathy, dilated, 1i 12.0
47 cardiomyopathy, dilated, 1m 12.0
48 cardiomyopathy, dilated, 1w 12.0
49 cardiomyopathy, dilated, 1z 12.0
50 cardiomyopathy, dilated, 2a 12.0

Graphical network of the top 20 diseases related to Dilated Cardiomyopathy:



Diseases related to Dilated Cardiomyopathy

Symptoms & Phenotypes for Dilated Cardiomyopathy

MGI Mouse Phenotypes related to Dilated Cardiomyopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.13 BAG3 CSRP3 DES DMD DSP LDB3
2 mortality/aging MP:0010768 9.97 BAG3 CSRP3 DES DMD DSG2 DSP
3 muscle MP:0005369 9.83 BAG3 CSRP3 DES DMD DSP LDB3
4 respiratory system MP:0005388 9.17 BAG3 CSRP3 DMD LDB3 LMNA NKX2-5

Drugs & Therapeutics for Dilated Cardiomyopathy

Drugs for Dilated Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 150)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carvedilol Approved, Investigational Phase 4,Phase 2 72956-09-3 2585
2
Verapamil Approved Phase 4 52-53-9 2520
3
Enalaprilat Approved Phase 4,Phase 2,Phase 3 76420-72-9 6917719
4
Enalapril Approved, Vet_approved Phase 4,Phase 2,Phase 3 75847-73-3 5362032 40466924
5
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
6
Metoprolol Approved, Investigational Phase 4,Phase 2 37350-58-6, 51384-51-1 4171
7
Angiotensin II Approved, Investigational Phase 4,Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
8
Benazepril Approved, Investigational Phase 4 86541-75-5 5362124
9
Doxazosin Approved Phase 4 74191-85-8 3157
10
Allopurinol Approved Phase 4,Phase 1,Phase 2 315-30-0 2094
11
Adenosine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 58-61-7 60961
12
Regadenoson Approved, Investigational Phase 4 313348-27-5 219024
13
Spironolactone Approved Phase 4,Phase 3,Phase 2 52-01-7, 1952-01-7 5833
14
Coenzyme Q10 Approved, Investigational, Nutraceutical Phase 4 303-98-0 5281915
15
Uric Acid Experimental, Investigational Phase 4 69-93-2 1175
16 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
17 Angiotensin-Converting Enzyme Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
18 calcium channel blockers Phase 4,Phase 2,Not Applicable
19 Neurotransmitter Agents Phase 4,Phase 2,Phase 1,Not Applicable
20 Anti-Arrhythmia Agents Phase 4,Not Applicable
21 Adrenergic alpha-1 Receptor Antagonists Phase 4
22 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
23 Vasodilator Agents Phase 4,Phase 3,Phase 2,Not Applicable
24 Adrenergic alpha-Antagonists Phase 4
25 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
26 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
27 Antihypertensive Agents Phase 4,Phase 2,Phase 3,Not Applicable
28 Angiotensin Receptor Antagonists Phase 4,Not Applicable
29 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
30
protease inhibitors Phase 4,Phase 2,Phase 3,Not Applicable
31 Diuretics, Potassium Sparing Phase 4,Phase 3,Phase 2
32 Trace Elements Phase 4,Phase 2,Not Applicable
33 Vitamins Phase 4
34 Ubiquinone Phase 4,Phase 2,Not Applicable
35 Micronutrients Phase 4,Phase 2,Not Applicable
36 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
37 Sympatholytics Phase 4,Not Applicable
38 Angiotensin II Type 1 Receptor Blockers Phase 4,Not Applicable
39 Adrenergic beta-1 Receptor Antagonists Phase 4,Not Applicable
40 Angiotensinogen Phase 4,Not Applicable
41 Autonomic Agents Phase 4,Phase 1,Phase 2,Not Applicable
42 Natriuretic Peptide, Brain Phase 4,Not Applicable
43 Free Radical Scavengers Phase 4,Phase 1,Phase 2
44 Antimetabolites Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
45 Antioxidants Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Antirheumatic Agents Phase 4,Phase 3,Phase 1,Phase 2
47 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Anticholesteremic Agents Phase 4,Phase 3
49 Lipid Regulating Agents Phase 4,Phase 3
50 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 195)
# Name Status NCT ID Phase Drugs
1 Danish ICD Study in Patients With Dilated Cardiomyopathy Unknown status NCT00542945 Phase 4
2 Therapy With Verapamil or Carvedilol in Chronic Heart Failure Unknown status NCT00374465 Phase 4 Verapamil;Carvedilol
3 Efficacy of Implantable Cardioverter Defibrillator in Patients With Non-ischemic Systolic Heart Failure on Mortality Unknown status NCT00541268 Phase 4
4 Coenzyme Q10 Supplementation in Children With Idiopathic Dilated Cardiomyopathy Completed NCT02115581 Phase 4 Coenzyme Q10;Placebo
5 Supramaximal Titrated Inhibition of RAAS in Dilated Cardiomyopathy Completed NCT01917149 Phase 4 Benazepril;Valsartan;Metoprolol
6 Study of Qiliqiangxin Capsule to Treat Dilated Cardiomyopathy Completed NCT01293903 Phase 4 Qiliqiangxin capsule;Placebo
7 Effect of Beta-blockers on Structural Remodeling and Gene Expression in the Failing Human Heart Completed NCT01798992 Phase 4 Carvedilol;Metoprolol succinate;Metoprolol succinate + doxazosin
8 ACC - Atrial Contribution to CRT Completed NCT00180323 Phase 4
9 A Randomized Trial of Carvedilol in Chronic Chagas Cardiomyopathy Completed NCT01557140 Phase 4 RASi plus carvedilol
10 Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients Completed NCT00477789 Phase 4 allopurinol
11 Effects of Early Statin Treatment After Acute Myocardial Infarction (AMI) in Japanese Patients Completed NCT00128024 Phase 4 lipid-lowering treatment
12 Microvascular Dysfunction in Nonischemic Cardiomyopathy: Insights From CMR Assessment of Coronary Flow Reserve Recruiting NCT03249272 Phase 4 Regadenoson;Adenosine
13 (MitraClip in Non-Responders to Cardiac Resynchronization Therapy) Recruiting NCT02592889 Phase 4
14 Pulse Reduction On Beta-blocker and Ivabradine Therapy Recruiting NCT02973594 Phase 4 Ivabradine;Placebo
15 Effect of Aldosterone on Energy Starvation in Heart Failure Active, not recruiting NCT00574119 Phase 4 spironolactone
16 Cardiac Sarcoidosis Response To Steroids Trial Withdrawn NCT01210677 Phase 4 Prednisone
17 Regression of Fatty Heart by Valsartan Therapy Withdrawn NCT00745953 Phase 4 Valsartan;Hydrochlorothiazide
18 Orodispersible Minitablets of Enalapril in Children With Heart Failure Due to Dilated Cardiomyopathy Unknown status NCT02652728 Phase 2, Phase 3 Enalapril Orodispersible Minitablet
19 Follow-up Safety Trial in Children With Chronic Heart Failure Therapy Receiving Orodispersible Minitablets of Enalapril Unknown status NCT02654678 Phase 2, Phase 3 Enalapril Orodispersible Minitablet
20 Cell Therapy In Dilated Cardiomyopathy Completed NCT00333827 Phase 3 optimal therapy for cardiaca failure
21 Honey in Idiopathic Dilated Cardiomyopathy Completed NCT02987322 Phase 2, Phase 3
22 Autologous Transplantation of Bone Marrow Mononuclear Stem-Cells for Dilated Cardiomyopathy Completed NCT00743639 Phase 2, Phase 3
23 Repetitive Intramyocardial CD34+ Cell Therapy in Dilated Cardiomyopathy (REMEDIUM) Completed NCT02248532 Phase 2, Phase 3
24 PUFAs and Left Ventricular Function in Heart Failure Completed NCT01223703 Phase 3 n-3 PUFAs;Placebo
25 A Randomized, Controlled Study to Evaluate Algisyl-LVR™ as a Method of Left Ventricular Augmentation for Heart Failure Completed NCT01311791 Phase 2, Phase 3 Standard medical therapy
26 Effect of Rosuvastatin on Left Ventricular Remodeling Completed NCT00505154 Phase 3 Rosuvastatin;placebo
27 The Acute Effects of the Angiotensin-converting Enzyme Inhibitor Enalaprilat on Flow Distribution Completed NCT00741156 Phase 3 Enalaprilat
28 Continues Positive Airway Pressure Treatment for Patients With Dilated Cardiomyopathy and Obstructive Sleep Apnea Recruiting NCT02989181 Phase 3
29 A Study of ARRY-371797 in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation Recruiting NCT03439514 Phase 3 ARRY-371797
30 Resveratrol: A Potential Anti- Remodeling Agent in Heart Failure, From Bench to Bedside Recruiting NCT01914081 Phase 3
31 CHICAMOCHA 3 - Equivalence of Usual Interventions for Trypanosomiasis (EQUITY) Recruiting NCT02369978 Phase 2, Phase 3 Nifurtimox;Benznidazole;Placebo
32 PHOspholamban RElated CArdiomyopathy STudy - Intervention Active, not recruiting NCT01857856 Phase 3 Eplerenone
33 PREclinical Mutation CARriers From Families With DIlated Cardiomyopathy and ACE Inhibitors Terminated NCT01583114 Phase 3 perindopril;placebo
34 Cell Therapy in Chagas Cardiomyopathy Terminated NCT00349271 Phase 3 Filgrastime (G-CSF);Standart therapy
35 Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure Terminated NCT00608140 Phase 3 Optimal medical therapy (OMT)
36 A Pilot Trial of Ranolazine to Treat Patients With Dilated Cardiomyopathy Unknown status NCT02133911 Phase 2 Ranolazine
37 Intramuscular Injection of Mesenchymal Stem Cell for Treatment of Children With Idiopathic Dilated Cardiomyopathy Unknown status NCT01219452 Phase 1, Phase 2
38 Intracoronary Autologous Mesenchymal Stem Cells Implantation in Patients With Ischemic Dilated Cardiomyopathy Unknown status NCT01720888 Phase 2
39 Mesenchymal Stem Cells for Idiopathic Dilated Cardiomyopathy Unknown status NCT01957826 Phase 1, Phase 2
40 Use of Ixmyelocel-T (Formerly Catheter-based Cardiac Repair Cell [CRC]) Treatment in Patients With Heart Failure Due to Dilated Cardiomyopathy Completed NCT01020968 Phase 2
41 Use of Ixmyelocel-T (Formerly Cardiac Repair Cell [CRC] Treatment) in Patients With Heart Failure Due to Dilated Cardiomyopathy (IMPACT-DCM) Completed NCT00765518 Phase 2
42 Safety and Efficacy Study of Stem Cell Transplantation to Treat Dilated Cardiomyopathy Completed NCT00629018 Phase 2 Bone Marrow Stimulation
43 Safety and Efficacy Study of Intramyocardial Stem Cell Therapy in Patients With Dilated Cardiomyopathy Completed NCT01350310 Phase 2
44 Bone Marrow Derived Adult Stem Cells for Dilated Cardiomyopathy Completed NCT01302171 Phase 2 granulocyte colony stimulating factor (GCSF)
45 Intracoronary Infusion of Autologous Bone Marrow Cells for Treatment of Idiopathic Dilated Cardiomyopathy Completed NCT00629096 Phase 2
46 PercutaneOus StEm Cell Injection Delivery Effects On Neomyogenesis in Dilated CardioMyopathy (The POSEIDON-DCM Study) Completed NCT01392625 Phase 1, Phase 2
47 An Efficacy, Safety and Tolerability Study of Ixmyelocel-T Administered Via Transendocardial Catheter-based Injections to Subjects With Heart Failure Due to Ischemic Dilated Cardiomyopathy (IDCM) Completed NCT01670981 Phase 2
48 Autologous Transplantation of Bone Marrow Mononuclear Stem-Cells by Mini-Thoracotomy Completed NCT00615394 Phase 1, Phase 2
49 Safety and Feasibility of Algisyl-LVR™ as a Method of Left Ventricular Restoration in Patients With DCM Undergoing Open-heart Surgery Completed NCT00847964 Phase 2
50 A Study of ARRY-371797 in Patients With LMNA-Related Dilated Cardiomyopathy Completed NCT02057341 Phase 2 ARRY-371797, p38 inhibitor; oral

Search NIH Clinical Center for Dilated Cardiomyopathy

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Dilated Cardiomyopathy cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: cardiomyopathy, dilated

Genetic Tests for Dilated Cardiomyopathy

Genetic tests related to Dilated Cardiomyopathy:

# Genetic test Affiliating Genes
1 Primary Dilated Cardiomyopathy 29 ABCC9 ACTC1 ACTN2 ANKRD1 BAG3 CSRP3 DES DSG2 EYA4 FKTN LDB3 LMNA MYBPC3 MYH6 NEXN PLN PSEN1 PSEN2 RBM20 SGCD TAZ TCAP TMPO TNNT2 TPM1 TTN VCL
2 Familial Dilated Cardiomyopathy 29
3 Dilated Cardiomyopathy 29

Anatomical Context for Dilated Cardiomyopathy

MalaCards organs/tissues related to Dilated Cardiomyopathy:

41
Heart, Bone, Bone Marrow, Testes, Endothelial, T Cells, Monocytes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Dilated Cardiomyopathy:
# Tissue Anatomical CompartmentCell Relevance
1 Heart Myocardium Cardiomyocytes Affected by disease
2 Heart Left Ventricle Cardiomyocytes Affected by disease, potential therapeutic candidate
3 Blood Cord Blood Mesenchymal Stem Cells Potential therapeutic candidate
4 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate

Publications for Dilated Cardiomyopathy

Articles related to Dilated Cardiomyopathy:

(show top 50) (show all 2837)
# Title Authors Year
1
Beta1-adrenergic receptor antibodies in children with dilated cardiomyopathy. ( 30468641 )
2019
2
Arrhythmic Genotypes in Familial Dilated Cardiomyopathy: Implications for Genetic Testing and Clinical Management. ( 30482687 )
2019
3
Genome sequencing as a first-line genetic test in familial dilated cardiomyopathy. ( 29961767 )
2018
4
Prognostic value of myocardial strain and late gadolinium enhancement on cardiovascular magnetic resonance imaging in patients with idiopathic dilated cardiomyopathy with moderate to severely reduced ejection fraction. ( 29898740 )
2018
5
Whole exome sequencing identifies a novel mutation (c.333a8^+a8^2Ta8^>a8^C) of TNNI3K in a Chinese family with dilated cardiomyopathy and cardiac conduction disease. ( 29355681 )
2018
6
Addition of Digoxin Improves Cardiac Function in Children With the Dilated Cardiomyopathy With Ataxia Syndrome: AA Mitochondrial Cardiomyopathy. ( 29887217 )
2018
7
Advanced Dilated Cardiomyopathy in a Patient With Hutterite Limb-Girdle Muscular Dystrophy: Use of a Left Ventricular Assist Device. ( 29626101 )
2018
8
Identification of cardiac long non-coding RNA profile in human dilated cardiomyopathy. ( 29365080 )
2018
9
Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation. ( 29878125 )
2018
10
A novel DMD splicing mutation found in a family responsible for X-linked dilated cardiomyopathy with hyper-CKemia. ( 29901616 )
2018
11
A morpho-functional study using PEP/LVET ratio and global longitudinal strain in patients with dilated cardiomyopathy. ( 29940616 )
2018
12
Correlations of GDF-15 with sST2, MMPs, and worsening functional capacity in idiopathic dilated cardiomyopathy: Can we gain new insights into the pathophysiology? ( 29375722 )
2018
13
Ion Channel Dysfunctions in Dilated Cardiomyopathy in Limb-Girdle Muscular Dystrophy. ( 29545480 )
2018
14
Cardiac specific expression of a88H2-R15 mini-dystrophin normalized all ECG abnormalities and the end-diastolic volume in a 23-m-old mouse model of Duchenne dilated cardiomyopathy. ( 29433343 )
2018
15
Sarcomeric Auto-Oscillations in Single Myofibrils From the Heart of Patients With Dilated Cardiomyopathy. ( 29980594 )
2018
16
Cardiac Nestin<sup>+</sup>Cells Derived from Early Stage of Dilated Cardiomyopathy Enhanced the Survival of the Doxorubicin-Injured Cardiac Muscle HL-1 Cells. ( 29375111 )
2018
17
ZBTB17 loss-of-function mutation contributes to familial dilated cardiomyopathy. ( 29445930 )
2018
18
Efficacy of cardiac resynchronization therapy in patients with isolated ventricular noncompaction with dilated cardiomyopathy: a systematic review of the literature. ( 29877973 )
2018
19
Is there a role for tissue Doppler imaging in predicting thromboembolic risk? A challenging case report of dilated cardiomyopathy with intracardiac thrombus and recurrent stroke. ( 29894356 )
2018
20
A Case of dilated Cardiomyopathy with Eosinophilic Granulomatosis with Polyangiitis in which Active Myocardial Inflammation was Only Detected by Endomyocardial Biopsy. ( 29709930 )
2018
21
Torsion Mechanics as an Indicator of More Advanced Left Ventricular Systolic Dysfunction in Secondary Mitral Regurgitation in Patients with Dilated Cardiomyopathy: A 2D Speckle-Tracking Analysis. ( 29408823 )
2018
22
Clinical Course and Treatment of Dilated Cardiomyopathy During Twenty Years of Follow-up. ( 29416222 )
2018
23
A novel splicing variant in FLNC gene responsible for a highly penetrant familial dilated cardiomyopathy in an extended Iranian family. ( 29551499 )
2018
24
Contractile reserve as a predictor of prognosis in patients with non-ischaemic systolic heart failure and dilated cardiomyopathy: a systematic review and meta-analysis. ( 29258998 )
2018
25
Pompe disease treatment with twice a week high dose alglucoside alfa in a patient with severe dilated cardiomyopathy. ( 29946513 )
2018
26
Effects of Repetitive Transendocardial CD34<sup>+</sup> Cell Transplantation in Patients with Non-Ischemic Dilated Cardiomyopathy. ( 29880546 )
2018
27
Fast apixaban-related resolution of left ventricular thrombi in a patient with dilated cardiomyopathy. ( 29374418 )
2018
28
No Obesity Paradox in Pediatric Patients With Dilated Cardiomyopathy. ( 29428438 )
2018
29
Two-year cardiac mortality after MitraClip treatment of functional mitral regurgitation in ischemic and non-ischemic dilated cardiomyopathy. ( 29929931 )
2018
30
Inherited dilated cardiomyopathy in a large Moroccan family caused by LMNA mutation. ( 29952368 )
2018
31
Dilated cardiomyopathy with re-worsening left ventricular ejection fraction. ( 29942977 )
2018
32
CD34<sup>+</sup>Cell Transplantation Improves Right Ventricular Function in Patients with Nonischemic Dilated Cardiomyopathy. ( 29380563 )
2018
33
Identification of new biophysical markers for pathological ventricular remodelling in tachycardia-induced dilated cardiomyopathy. ( 29921039 )
2018
34
Atypical Presentation of a Large Pericardial Effusion after Heart Transplantation in a Patient with Dilated Cardiomyopathy. ( 29429930 )
2018
35
Dilated cardiomyopathy complicated with visceral heterotaxy. ( 29040450 )
2018
36
A new phenotype of severe dilated cardiomyopathy associated with a mutation in the LAMP2 gene previously known to cause hypertrophic cardiomyopathy in the context of Danon disease. ( 29753918 )
2018
37
Dilated Cardiomyopathy in a Child with Recessive Dystrophic Epidermolysis Bullosa. ( 29699768 )
2018
38
Myocardium of patients with dilated cardiomyopathy presents altered expression of genes involved in thyroid hormone biosynthesis. ( 29320567 )
2018
39
Pediatric Dilated Cardiomyopathy-Associated<i>LRRC10</i>(Leucine-Rich Repeat-Containing 10) Variant Reveals LRRC10 as an Auxiliary Subunit of Cardiac L-Type Ca<sup>2+</sup>Channels. ( 29431102 )
2018
40
Potential for and timing of recovery in children with dilated cardiomyopathy. ( 29887441 )
2018
41
Late restored cardiac function after successful resynchronization by right posterior accessory pathway ablation in Wolff-Parkinson-White syndrome associated dilated cardiomyopathy. ( 29452709 )
2018
42
GDF-15 is a better complimentary marker for risk stratification of arrhythmic death in non-ischaemic, dilated cardiomyopathy than soluble ST2. ( 29397580 )
2018
43
A gene-centric strategy for identifying disease-causing rare variants in dilated cardiomyopathy. ( 29892087 )
2018
44
Identifying Non-invasive Tools to Distinguish Acute Myocarditis from Dilated Cardiomyopathy in Children. ( 29651540 )
2018
45
Influence of LGALS3 gene polymorphisms on susceptibility and prognosis of dilated cardiomyopathy in a Northern Han Chinese population. ( 29129812 )
2018
46
X-Linked Dilated Cardiomyopathy Presenting as Acute Rhabdomyolysis and Presumed Epstein-Barr Virus-Induced Viral Myocarditis: A Case Report. ( 29891833 )
2018
47
Cardiac Amyloidosis Mimicking Dilated Cardiomyopathy But Showing Relative Apical Sparing of Longitudinal Strain. ( 29877202 )
2018
48
Rare genetic mutations in Pakistani patients with dilated cardiomyopathy. ( 29886034 )
2018
49
The pathogenic gene screening in a Chinese familial dilated cardiomyopathy pedigree from Hubei. ( 29109008 )
2018
50
Dilated cardiomyopathy secondary to acute pancreatitis caused by hypertriglyceridemia. ( 29876048 )
2018

Variations for Dilated Cardiomyopathy

ClinVar genetic disease variations for Dilated Cardiomyopathy:

6 (show top 50) (show all 1969)
# Gene Variation Type Significance SNP ID Assembly Location
1 RBM20 NM_001134363.2(RBM20): c.1913C> T (p.Pro638Leu) single nucleotide variant Pathogenic rs267607003 GRCh37 Chromosome 10, 112572068: 112572068
2 RBM20 NM_001134363.2(RBM20): c.1913C> T (p.Pro638Leu) single nucleotide variant Pathogenic rs267607003 GRCh38 Chromosome 10, 110812310: 110812310
3 RBM20 NM_001134363.2(RBM20): c.1906C> A (p.Arg636Ser) single nucleotide variant Pathogenic/Likely pathogenic rs267607002 GRCh37 Chromosome 10, 112572061: 112572061
4 RBM20 NM_001134363.2(RBM20): c.1906C> A (p.Arg636Ser) single nucleotide variant Pathogenic/Likely pathogenic rs267607002 GRCh38 Chromosome 10, 110812303: 110812303
5 RBM20 NM_001134363.2(RBM20): c.1907G> A (p.Arg636His) single nucleotide variant Pathogenic/Likely pathogenic rs267607004 GRCh37 Chromosome 10, 112572062: 112572062
6 RBM20 NM_001134363.2(RBM20): c.1907G> A (p.Arg636His) single nucleotide variant Pathogenic/Likely pathogenic rs267607004 GRCh38 Chromosome 10, 110812304: 110812304
7 NEXN NM_144573.3(NEXN): c.1955A> G (p.Tyr652Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs137853197 GRCh37 Chromosome 1, 78408441: 78408441
8 NEXN NM_144573.3(NEXN): c.1955A> G (p.Tyr652Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs137853197 GRCh38 Chromosome 1, 77942756: 77942756
9 LDB3 NM_001080114.1(LDB3): c.494C> T (p.Ala165Val) single nucleotide variant Pathogenic rs121908334 GRCh37 Chromosome 10, 88446975: 88446975
10 LDB3 NM_001080114.1(LDB3): c.494C> T (p.Ala165Val) single nucleotide variant Pathogenic rs121908334 GRCh38 Chromosome 10, 86687218: 86687218
11 LDB3 NM_001080116.1(LDB3): c.349G> A (p.Asp117Asn) single nucleotide variant Conflicting interpretations of pathogenicity rs121908338 GRCh37 Chromosome 10, 88446830: 88446830
12 LDB3 NM_001080116.1(LDB3): c.349G> A (p.Asp117Asn) single nucleotide variant Conflicting interpretations of pathogenicity rs121908338 GRCh38 Chromosome 10, 86687073: 86687073
13 TCAP NM_003673.3(TCAP): c.157C> T (p.Gln53Ter) single nucleotide variant Likely pathogenic rs104894655 GRCh37 Chromosome 17, 37822015: 37822015
14 TCAP NM_003673.3(TCAP): c.157C> T (p.Gln53Ter) single nucleotide variant Likely pathogenic rs104894655 GRCh38 Chromosome 17, 39665762: 39665762
15 CSRP3 NM_003476.4(CSRP3): c.10T> C (p.Trp4Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs45550635 GRCh37 Chromosome 11, 19213986: 19213986
16 CSRP3 NM_003476.4(CSRP3): c.10T> C (p.Trp4Arg) single nucleotide variant Conflicting interpretations of pathogenicity rs45550635 GRCh38 Chromosome 11, 19192439: 19192439
17 SCN5A NM_001099404.1(SCN5A): c.892G> A (p.Gly298Ser) single nucleotide variant Uncertain significance rs137854608 GRCh37 Chromosome 3, 38651267: 38651267
18 SCN5A NM_001099404.1(SCN5A): c.892G> A (p.Gly298Ser) single nucleotide variant Uncertain significance rs137854608 GRCh38 Chromosome 3, 38609776: 38609776
19 SCN5A NM_000335.4(SCN5A): c.4780G> C (p.Asp1594His) single nucleotide variant Pathogenic rs137854607 GRCh37 Chromosome 3, 38595800: 38595800
20 SCN5A NM_000335.4(SCN5A): c.4780G> C (p.Asp1594His) single nucleotide variant Pathogenic rs137854607 GRCh38 Chromosome 3, 38554309: 38554309
21 TNNT2 NM_001001430.2(TNNT2): c.421C> T (p.Arg141Trp) single nucleotide variant Pathogenic rs74315379 GRCh37 Chromosome 1, 201333464: 201333464
22 TNNT2 NM_001001430.2(TNNT2): c.421C> T (p.Arg141Trp) single nucleotide variant Pathogenic rs74315379 GRCh38 Chromosome 1, 201364336: 201364336
23 TNNT2 NM_001001430.2(TNNT2): c.391C> T (p.Arg131Trp) single nucleotide variant Pathogenic/Likely pathogenic rs74315380 GRCh37 Chromosome 1, 201333494: 201333494
24 TNNT2 NM_001001430.2(TNNT2): c.391C> T (p.Arg131Trp) single nucleotide variant Pathogenic/Likely pathogenic rs74315380 GRCh38 Chromosome 1, 201364366: 201364366
25 TTN NM_001256850.1(TTN): c.2926T> C (p.Trp976Arg) single nucleotide variant Pathogenic rs267607155 GRCh37 Chromosome 2, 179647707: 179647707
26 TTN NM_001256850.1(TTN): c.2926T> C (p.Trp976Arg) single nucleotide variant Pathogenic rs267607155 GRCh38 Chromosome 2, 178782980: 178782980
27 TMPO NM_003276.2(TMPO): c.2068C> T (p.Arg690Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs17028450 GRCh37 Chromosome 12, 98928103: 98928103
28 TMPO NM_003276.2(TMPO): c.2068C> T (p.Arg690Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs17028450 GRCh38 Chromosome 12, 98534325: 98534325
29 PLN NM_002667.4(PLN): c.25C> T (p.Arg9Cys) single nucleotide variant Pathogenic rs111033559 GRCh37 Chromosome 6, 118880109: 118880109
30 PLN NM_002667.4(PLN): c.25C> T (p.Arg9Cys) single nucleotide variant Pathogenic rs111033559 GRCh38 Chromosome 6, 118558946: 118558946
31 PLN NM_002667.4(PLN): c.116T> G (p.Leu39Ter) single nucleotide variant Pathogenic rs111033560 GRCh37 Chromosome 6, 118880200: 118880200
32 PLN NM_002667.4(PLN): c.116T> G (p.Leu39Ter) single nucleotide variant Pathogenic rs111033560 GRCh38 Chromosome 6, 118559037: 118559037
33 MYH7 NM_000257.3(MYH7): c.1594T> C (p.Ser532Pro) single nucleotide variant Pathogenic rs121913642 GRCh37 Chromosome 14, 23897088: 23897088
34 MYH7 NM_000257.3(MYH7): c.1594T> C (p.Ser532Pro) single nucleotide variant Pathogenic rs121913642 GRCh38 Chromosome 14, 23427879: 23427879
35 MYH7 NM_000257.3(MYH7): c.732+1G> A single nucleotide variant Pathogenic/Likely pathogenic rs730880850 GRCh38 Chromosome 14, 23431584: 23431584
36 MYH7 NM_000257.3(MYH7): c.732+1G> A single nucleotide variant Pathogenic/Likely pathogenic rs730880850 GRCh37 Chromosome 14, 23900793: 23900793
37 MYH6 NM_002471.3(MYH6): c.3195G> C (p.Gln1065His) single nucleotide variant Conflicting interpretations of pathogenicity rs267606904 GRCh37 Chromosome 14, 23862177: 23862177
38 MYH6 NM_002471.3(MYH6): c.3195G> C (p.Gln1065His) single nucleotide variant Conflicting interpretations of pathogenicity rs267606904 GRCh38 Chromosome 14, 23392968: 23392968
39 MYH6 NM_002471.3(MYH6): c.3195G> C (p.Gln1065His) single nucleotide variant Conflicting interpretations of pathogenicity rs267606904 NCBI36 Chromosome 14, 22932017: 22932017
40 MYH6 NM_002471.3(MYH6): c.3010G> T (p.Ala1004Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs143978652 GRCh37 Chromosome 14, 23862646: 23862646
41 MYH6 NM_002471.3(MYH6): c.3010G> T (p.Ala1004Ser) single nucleotide variant Conflicting interpretations of pathogenicity rs143978652 GRCh38 Chromosome 14, 23393437: 23393437
42 LMNA NM_170707.3(LMNA): c.16C> T (p.Gln6Ter) single nucleotide variant Pathogenic rs61046466 GRCh37 Chromosome 1, 156084725: 156084725
43 LMNA NM_170707.3(LMNA): c.16C> T (p.Gln6Ter) single nucleotide variant Pathogenic rs61046466 GRCh38 Chromosome 1, 156114934: 156114934
44 LMNA NM_170707.3(LMNA): c.585C> G (p.Asn195Lys) single nucleotide variant Pathogenic rs28933091 GRCh37 Chromosome 1, 156104265: 156104265
45 LMNA NM_170707.3(LMNA): c.585C> G (p.Asn195Lys) single nucleotide variant Pathogenic rs28933091 GRCh38 Chromosome 1, 156134474: 156134474
46 LMNA NM_170707.3(LMNA): c.608A> G (p.Glu203Gly) single nucleotide variant Pathogenic rs28933092 GRCh37 Chromosome 1, 156104288: 156104288
47 LMNA NM_170707.3(LMNA): c.608A> G (p.Glu203Gly) single nucleotide variant Pathogenic rs28933092 GRCh38 Chromosome 1, 156134497: 156134497
48 LMNA NM_170707.3(LMNA): c.481G> A (p.Glu161Lys) single nucleotide variant Pathogenic/Likely pathogenic rs28933093 GRCh37 Chromosome 1, 156100532: 156100532
49 LMNA NM_170707.3(LMNA): c.481G> A (p.Glu161Lys) single nucleotide variant Pathogenic/Likely pathogenic rs28933093 GRCh38 Chromosome 1, 156130741: 156130741
50 LMNA NM_170707.3(LMNA): c.1930C> T (p.Arg644Cys) single nucleotide variant Conflicting interpretations of pathogenicity rs142000963 GRCh37 Chromosome 1, 156108510: 156108510

Expression for Dilated Cardiomyopathy

Search GEO for disease gene expression data for Dilated Cardiomyopathy.

Pathways for Dilated Cardiomyopathy

Pathways related to Dilated Cardiomyopathy according to KEGG:

37
# Name Kegg Source Accession
1 Dilated cardiomyopathy (DCM) hsa05414

Pathways related to Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.58 DES DMD MYBPC3 NKX2-5 PLN SCN5A
2
Show member pathways
12.56 MYH7 PLN SCN5A TNNI3 TNNT2 TPM1
3 12.34 DES LMNA TNNI3 TNNT2 TPM1
4
Show member pathways
12.24 DES DMD DSG2 DSP LMNA
5 11.81 NKX2-5 TNNI3 TNNT2
6
Show member pathways
11.72 DSG2 DSP LMNA
7 11.56 MYH7 TNNI3 TNNT2 TPM1
8
Show member pathways
11.56 DES DMD LMNA MYBPC3 MYH7 PLN
9 11.37 DSP LMNA PLN SCN5A
10 11.36 DES DMD MYBPC3 TNNI3 TNNT2 TPM1
11 11.28 NKX2-5 SCN5A TNNI3 TNNT2
12 10.84 MYH7 NKX2-5

GO Terms for Dilated Cardiomyopathy

Cellular components related to Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 sarcolemma GO:0042383 9.67 DES DMD SCN5A
2 myofibril GO:0030016 9.65 DMD MYH7 TNNI3 TNNT2 TPM1
3 intercalated disc GO:0014704 9.62 DES DSG2 DSP SCN5A
4 lateral plasma membrane GO:0016328 9.61 DMD DSG2 SCN5A
5 striated muscle thin filament GO:0005865 9.54 MYBPC3 TNNT2 TTN
6 myosin filament GO:0032982 9.52 MYBPC3 MYH7
7 contractile fiber GO:0043292 9.51 DES TNNI3
8 sarcomere GO:0030017 9.5 CSRP3 MYBPC3 MYH7 TNNI3 TNNT2 TPM1
9 fascia adherens GO:0005916 9.48 DES DSP
10 troponin complex GO:0005861 9.46 TNNI3 TNNT2
11 cardiac myofibril GO:0097512 9.46 DES MYBPC3 TNNI3 TNNT2
12 cardiac Troponin complex GO:1990584 9.4 TNNI3 TNNT2
13 Z disc GO:0030018 9.28 BAG3 CSRP3 DES DMD LDB3 MYBPC3

Biological processes related to Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 cellular calcium ion homeostasis GO:0006874 9.83 CSRP3 PLN TNNI3
2 muscle contraction GO:0006936 9.8 DES MYBPC3 MYH7 TNNI3 TNNT2 TPM1
3 positive regulation of ATPase activity GO:0032781 9.75 MYBPC3 TNNT2 TPM1
4 regulation of heart rate by cardiac conduction GO:0086091 9.73 DSG2 DSP SCN5A
5 regulation of heart rate GO:0002027 9.72 DMD MYH7 SCN5A
6 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.72 MYBPC3 MYH7 TNNI3 TNNT2 TPM1
7 skeletal muscle contraction GO:0003009 9.71 MYH7 TNNI3 TNNT2
8 cardiac muscle tissue morphogenesis GO:0055008 9.7 MYBPC3 NKX2-5 TTN
9 regulation of the force of heart contraction GO:0002026 9.69 CSRP3 MYH7 PLN
10 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.67 DMD PLN
11 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.67 DMD PLN
12 intermediate filament organization GO:0045109 9.67 DES DSP
13 cardiac myofibril assembly GO:0055003 9.67 CSRP3 MYBPC3 TTN
14 regulation of heart contraction GO:0008016 9.67 DES PLN TNNT2 TPM1
15 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.66 DMD PLN
16 cardiac muscle fiber development GO:0048739 9.66 MYBPC3 TTN
17 positive regulation of sodium ion transport GO:0010765 9.65 NKX2-5 SCN5A
18 adult heart development GO:0007512 9.65 MYH7 NKX2-5
19 regulation of muscle contraction GO:0006937 9.65 TNNI3 TNNT2 TPM1
20 cardiac muscle contraction GO:0060048 9.65 CSRP3 DMD MYBPC3 MYH7 NKX2-5 SCN5A
21 heart contraction GO:0060047 9.64 NKX2-5 TNNI3
22 skeletal muscle thin filament assembly GO:0030240 9.64 MYBPC3 TTN
23 regulation of cardiac muscle cell contraction GO:0086004 9.63 PLN SCN5A
24 cardiac muscle hypertrophy GO:0003300 9.63 CSRP3 TTN
25 cardiac muscle tissue development GO:0048738 9.63 CSRP3 NKX2-5 PLN
26 sarcomere organization GO:0045214 9.63 LDB3 MYBPC3 NKX2-5 TNNT2 TPM1 TTN
27 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.62 DSG2 DSP
28 response to denervation involved in regulation of muscle adaptation GO:0014894 9.62 DMD SCN5A
29 skeletal muscle myosin thick filament assembly GO:0030241 9.61 MYBPC3 TTN
30 transition between fast and slow fiber GO:0014883 9.61 MIR499A MYH7
31 striated muscle contraction GO:0006941 9.61 MYH7 TNNI3 TTN
32 ventricular cardiac muscle cell development GO:0055015 9.6 LMNA NKX2-5
33 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.59 DSG2 DSP
34 desmosome organization GO:0002934 9.58 DSG2 DSP
35 negative regulation of ATPase activity GO:0032780 9.58 PLN TNNI3 TNNT2
36 detection of muscle stretch GO:0035995 9.57 CSRP3 TTN
37 muscle filament sliding GO:0030049 9.23 DES DMD MYBPC3 MYH7 TNNI3 TNNT2

Molecular functions related to Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cytoskeletal protein binding GO:0008092 9.65 DES LDB3 TPM1
2 actin filament binding GO:0051015 9.65 MYBPC3 MYH7 TNNI3 TPM1 TTN
3 structural constituent of cytoskeleton GO:0005200 9.62 DES DMD DSP TPM1
4 actin binding GO:0003779 9.5 CSRP3 DMD MYBPC3 MYH7 TNNI3 TNNT2
5 nitric-oxide synthase binding GO:0050998 9.49 DMD SCN5A
6 actinin binding GO:0042805 9.46 CSRP3 TTN
7 telethonin binding GO:0031433 9.43 CSRP3 TTN
8 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 9.4 DSG2 DSP
9 troponin C binding GO:0030172 9.37 TNNI3 TNNT2
10 muscle alpha-actinin binding GO:0051371 9.33 LDB3 MYBPC3 TTN
11 structural constituent of muscle GO:0008307 9.02 CSRP3 DMD MYBPC3 TPM1 TTN
12 protein binding GO:0005515 10.41 BAG3 CSRP3 DES DMD DSP LDB3
13 identical protein binding GO:0042802 10 CSRP3 DES MYBPC3 PLN TPM1 TTN

Sources for Dilated Cardiomyopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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