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DCM
MCID: DLT002
MIFTS: 79

Dilated Cardiomyopathy (DCM)

Categories: Blood diseases, Bone diseases, Cardiovascular diseases, Ear diseases, Genetic diseases, Immune diseases, Neuronal diseases, Rare diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Dilated Cardiomyopathy

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MalaCards integrated aliases for Dilated Cardiomyopathy:

Name: Dilated Cardiomyopathy 12 74 24 52 58 36 29 54 6 15 37 17 32
Familial Dilated Cardiomyopathy 12 74 52 25 58 29 6 71
Idiopathic Dilation Cardiomyopathy 12 74 71
Primary Dilated Cardiomyopathy 12 29 6
Cardiomyopathy, Dilated 43 39 71
Idiopathic Dilated Cardiomyopathy 52 17
Congestive Cardiomyopathy 12 25
Dcm 52 47
Hypokinetic Dilated Cardiomyopathy, Familial 52
Primary Familial Dilated Cardiomyopathy 25
Cardiomyopathy, Familial Idiopathic 71
Familial Idiopathic Cardiomyopathy 25
Cardiomyopathy, Familial Dilated 52
Dilated Cardiomyopathy, Familial 52
Fdc 25

Characteristics:

Orphanet epidemiological data:

58
dilated cardiomyopathy
Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Cardiovascular diseases Respiratory diseases Blood diseases Immune diseases Neuronal diseases Bone diseases Ear diseases
See all MalaCards categories (disease lists)
ICD10: 32 33


External Ids:

Disease Ontology 12 DOID:12930
KEGG 36 H00294
MeSH 43 D002311
NCIt 49 C84673
SNOMED-CT 67 399020009
ICD10 32 I42.0
MESH via Orphanet 44 C536231 D002311
ICD10 via Orphanet 33 I42.0
UMLS via Orphanet 72 C0007193 C0340427
UMLS 71 C0007193 C0340427 C1449563 more
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Summaries for Dilated Cardiomyopathy

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KEGG : 36 Dilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac death from ventricular arrhythmia. Genetically inherited forms of DCM ("familial" DCM) have been identified in 25-35% of patients presenting with this disease, and the inherited gene defects are an important cause of "familial" DCM. The pathophysiology may be separated into two categories: defects in force generation and defects in force transmission. In cases where an underlying pathology cannot be identified, the patient is diagnosed with an "idiopathic" DCM. Current hypotheses regarding causes of "idiopathic" DCM focus on myocarditis induced by enterovirus and subsequent autoimmune myocardium impairments. Antibodies to the beta1-adrenergic receptor (beta1AR), which are detected in a substantial number of patients with "idiopathic" DCM, may increase the concentration of intracellular cAMP and intracellular Ca2+, a condition often leading to a transient hyper-performance of the heart followed by depressed heart function and heart failure.

MalaCards based summary : Dilated Cardiomyopathy, also known as familial dilated cardiomyopathy, is related to familial isolated dilated cardiomyopathy and cardiomyopathy, dilated, 1e. An important gene associated with Dilated Cardiomyopathy is LMNA (Lamin A/C), and among its related pathways/superpathways are Dilated cardiomyopathy (DCM) and Cardiac conduction. The drugs Verapamil and Metoprolol have been mentioned in the context of this disorder. Affiliated tissues include Heart, and related phenotypes are failure to thrive and dyspnea

Disease Ontology : 12 An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently.

Genetics Home Reference : 25 Familial dilated cardiomyopathy is a genetic form of heart disease. It occurs when heart (cardiac) muscle becomes thin and weakened in at least one chamber of the heart, causing the open area of the chamber to become enlarged (dilated). As a result, the heart is unable to pump blood as efficiently as usual. To compensate, the heart attempts to increase the amount of blood being pumped through the heart, leading to further thinning and weakening of the cardiac muscle. Over time, this condition results in heart failure. It usually takes many years for symptoms of familial dilated cardiomyopathy to cause health problems. They typically begin in mid-adulthood, but can occur at any time from infancy to late adulthood. Signs and symptoms of familial dilated cardiomyopathy can include an irregular heartbeat (arrhythmia), shortness of breath (dyspnea), extreme tiredness (fatigue), fainting episodes (syncope), and swelling of the legs and feet. In some cases, the first sign of the disorder is sudden cardiac death. The severity of the condition varies among affected individuals, even in members of the same family.

NIH Rare Diseases : 52 Dilated cardiomyopathy (DCM) is a disease of the heart muscle which primarily affects the heart's main pumping chamber, the left ventricle. It is the most common type of cardiomyopathy and typically affects those aged 20 to 60. The left ventricle of affected individuals becomes enlarged (dilated) and cannot pump blood to the body with as much force as a healthy heart can. The heart muscle also has difficulty contracting normally, which can lead to irregular heartbeats (arrhythmia ), blood clots, or sudden death. Over time, the heart becomes weaker and heart failure can occur. While the cause of dilated cardiomyopathy is often unknown (idiopathic), some cases are acquired and roughly half are inherited or familial . Also, DCM can be a feature of many genetic syndromes . Familial dilated cardiomyopathy is most often inherited in an autosomal dominant pattern. Familial dilated cardiomyopathy is caused by mutations in several different genes , most commonly in the TTN gene (found in about 20% of cases). DCM treatment may include medication, pacemakers , implantable cardiac defibrillators , or heart transplantation .

Wikipedia : 74 Dilated cardiomyopathy (DCM) is a condition in which the heart becomes enlarged and cannot pump blood... more...

GeneReviews: NBK1309
Sources

Related Diseases for Dilated Cardiomyopathy

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Diseases in the Rare Cardiomyopathy family:

Cardiomyopathy, Dilated, 1a Cardiomyopathy, Dilated, 3b
Cardiomyopathy, Dilated, 1b Cardiomyopathy, Dilated, 1e
Cardiomyopathy, Dilated, 1d Cardiomyopathy, Dilated, 1g
Cardiomyopathy, Dilated, 1h Cardiomyopathy, Dilated, 1i
Cardiomyopathy, Dilated, 1j Cardiomyopathy, Dilated, 1k
Cardiomyopathy, Dilated, 1l Cardiomyopathy, Dilated, 1m
Cardiomyopathy, Dilated, 1o Cardiomyopathy, Dilated, 1p
Cardiomyopathy, Dilated, 1q Cardiomyopathy, Dilated, 1w
Cardiomyopathy, Dilated, 1x Cardiomyopathy, Dilated, 1z
Cardiomyopathy, Dilated, 2a Cardiomyopathy, Dilated, 1bb
Cardiomyopathy, Dilated, 1cc Cardiomyopathy, Dilated, 1dd
Cardiomyopathy, Dilated, 1ee Cardiomyopathy, Dilated, 1ff
Cardiomyopathy, Dilated, 1r Cardiomyopathy, Dilated, 1gg
Cardiomyopathy, Dilated, 1u Cardiomyopathy, Dilated, 1v
Cardiomyopathy, Dilated, 1hh Cardiomyopathy, Dilated, 2b
Cardiomyopathy, Dilated, 1ii Cardiomyopathy, Dilated, 1jj
Cardiomyopathy, Dilated, 1kk Cardiomyopathy, Dilated, 1nn
Cardiomyopathy, Dilated, 2c Autoimmune Cardiomyopathy
Dilated Cardiomyopathy 1t Dilated Cardiomyopathy
Lmna-Related Dilated Cardiomyopathy Cardiomyopathy Due to Anthracyclines

Diseases related to Dilated Cardiomyopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 952)
# Related Disease Score Top Affiliating Genes
1 familial isolated dilated cardiomyopathy 37.2 TTN TPM1 TNNT2 TNNI3 TAZ SCN5A
2 cardiomyopathy, dilated, 1e 36.1 TTN TPM1 SCN5A RBM20 MYH7 LMNA
3 atrial standstill 1 35.9 TTN TPM1 TNNT2 TNNI3 TAZ SCN5A
4 cardiomyopathy, dilated, 1b 35.7 TTN SCN5A RBM20 MYH7 MYH6 MYBPC3
5 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 35.5 SCN5A MYH7 DSP
6 hypertrophic cardiomyopathy 35.0 TTN TPM1 TNNT2 TNNI3 TAZ SCN5A
7 cardiomyopathy, dilated, 1ee 34.9 TPM1 MYH6
8 cardiomyopathy, dilated, 1dd 34.9 TTN RBM20
9 cardiomyopathy, dilated, 3b 34.6 TAZ DMD
10 cardiomyopathy, dilated, with woolly hair and keratoderma 34.5 DSP DSG2
11 myopathy, myofibrillar, 1 34.5 TTN LMNA DMD DES BAG3
12 danon disease 34.4 MYH7 MYH6 MYBPC3 LAMP2 CSRP3
13 barth syndrome 34.4 TAZ MYH7 MYH6 MYBPC3
14 myocarditis 34.3 TNNI3 MYH6 DSP DMD
15 left ventricular noncompaction 34.3 TTN TPM1 TNNT2 TNNI3 TAZ SCN5A
16 congestive heart failure 34.2 TTN TNNT2 TNNI3 SCN5A PLN MYH7
17 peripartum cardiomyopathy 34.2 TTN SCN5A MYH7
18 myopathy 34.1 TTN TPM1 TNNT2 TNNI3 TAZ MYH7
19 congenital fiber-type disproportion 34.1 TTN MYH7 MYH6 LMNA DMD
20 heart disease 34.1 TTN TNNT2 TNNI3 TAZ SCN5A MYH7
21 muscular dystrophy 33.7 TTN TNNT2 TNNI3 MYH7 LMNA DMD
22 arrhythmogenic right ventricular cardiomyopathy 33.6 TTN SCN5A RBM20 PLN MYH7 MYH6
23 restrictive cardiomyopathy 33.5 TTN TPM1 TNNT2 TNNI3 RBM20 MYH7
24 cardiac conduction defect 33.5 SCN5A PLN MYH7 MYBPC3 LMNA DSP
25 brugada syndrome 33.4 TTN TPM1 TNNT2 TNNI3 SCN5A RBM20
26 cardiac arrest 33.3 TTN TNNT2 SCN5A RBM20 PLN MYH7
27 left bundle branch hemiblock 33.2 TNNT2 TNNI3 SCN5A LMNA DSP DSG2
28 mitral valve insufficiency 33.2 TNNT2 TNNI3 MYH6 MYBPC3
29 long qt syndrome 33.2 TTN SCN5A RBM20 MYH7 MYH6 MYBPC3
30 atrioventricular block 33.1 TTN TNNI3 SCN5A MYH7 LMNA DES
31 progressive familial heart block, type ia 32.9 TTN SCN5A MYBPC3
32 syncope 32.8 TTN TNNT2 SCN5A ACTN2
33 atrial fibrillation 32.8 TTN TNNT2 TNNI3 SCN5A MYH7 MYBPC3
34 ventricular fibrillation, paroxysmal familial, 1 32.7 TNNT2 SCN5A DSP
35 neuromuscular disease 32.7 TTN SCN5A MYH7 MYH6 LMNA DMD
36 muscular dystrophy, duchenne type 32.6 TTN TNNT2 TNNI3 DMD DES
37 wolff-parkinson-white syndrome 32.6 TNNT2 TNNI3 SCN5A MYH7 MYH6 MYBPC3
38 lipoprotein quantitative trait locus 32.6 TNNT2 TNNI3 SCN5A MYH6
39 endocardial fibroelastosis 32.5 TAZ MYH7 CSRP3 ACTN2
40 atrial heart septal defect 32.5 TTN TNNT2 TNNI3 SCN5A MYH7 MYH6
41 cardiomyopathy, familial hypertrophic, 1 32.4 TTN TPM1 TNNT2 MYH7 MYH6 MYBPC3
42 amyloidosis 32.2 TTN TNNT2 TNNI3 MYBPC3
43 sick sinus syndrome 32.2 TTN SCN5A MYH6 LMNA
44 emery-dreifuss muscular dystrophy 32.2 LMNA DMD DES
45 right bundle branch block 32.1 TNNI3 SCN5A DSG2
46 limb-girdle muscular dystrophy 32.1 TTN LMNA DMD
47 aortic valve disease 2 32.1 TTN TNNT2 TNNI3 MYH7 MYH6 MYBPC3
48 tetralogy of fallot 32.1 TPM1 TNNT2 TNNI3 SCN5A MYH6 ACTN2
49 myofibrillar myopathy 32.0 TTN MYH7 MYH6 LMNA DMD DES
50 cardiomyopathy, familial hypertrophic, 4 32.0 TTN TPM1 TNNT2 MYH7 MYBPC3 DMD

Graphical network of the top 20 diseases related to Dilated Cardiomyopathy:



Diseases related to Dilated Cardiomyopathy
Sources

Symptoms & Phenotypes for Dilated Cardiomyopathy

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Human phenotypes related to Dilated Cardiomyopathy:

58 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 failure to thrive 58 Frequent (79-30%)
2 dyspnea 58 Frequent (79-30%)
3 arrhythmia 58 Frequent (79-30%)
4 congestive heart failure 58 Frequent (79-30%)
5 cough 58 Occasional (29-5%)
6 abnormal levels of creatine kinase in blood 58 Occasional (29-5%)
7 mitral regurgitation 58 Occasional (29-5%)
8 left ventricular hypertrophy 58 Very frequent (99-80%)
9 atrial fibrillation 58 Frequent (79-30%)
10 reduced ejection fraction 58 Frequent (79-30%)
11 coronary artery atherosclerosis 58 Excluded (0%)
12 palpitations 58 Occasional (29-5%)
13 ventricular arrhythmia 58 Occasional (29-5%)
14 elevated pulmonary artery pressure 58 Occasional (29-5%)
15 right ventricular dilatation 58 Frequent (79-30%)
16 left ventricular systolic dysfunction 58 Very frequent (99-80%)
17 left bundle branch block 58 Occasional (29-5%)

MGI Mouse Phenotypes related to Dilated Cardiomyopathy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 BAG3 CSRP3 DES DMD DSG2 DSP
2 cellular MP:0005384 10 BAG3 CSRP3 DES DMD DSG2 DSP
3 mortality/aging MP:0010768 10 BAG3 CSRP3 DES DMD DSG2 DSP
4 muscle MP:0005369 9.86 BAG3 CSRP3 DES DMD DSG2 DSP
5 respiratory system MP:0005388 9.17 BAG3 CSRP3 DMD LMNA MYH6 SCN5A
Sources

Drugs & Therapeutics for Dilated Cardiomyopathy

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Drugs for Dilated Cardiomyopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 162)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Verapamil Approved Phase 4 52-53-9 2520
2
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
3
Benazepril Approved, Investigational Phase 4 86541-75-5 5362124
4
Doxazosin Approved Phase 4 74191-85-8 3157
5
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
6
Regadenoson Approved, Investigational Phase 4 313348-27-5 219024
7
Adenosine Approved, Investigational Phase 4 58-61-7 60961
8
Allopurinol Approved Phase 4 315-30-0 2094
9
Enalapril Approved, Vet_approved Phase 4 75847-73-3 40466924 5362032
10
Enalaprilat Approved Phase 4 76420-72-9 6917719
11
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
12
Digoxin Approved Phase 4 20830-75-5 30322 2724385
13
Liraglutide Approved Phase 4 204656-20-2 44147092
14
Glucagon Approved Phase 4 16941-32-5
15
Irbesartan Approved, Investigational Phase 4 138402-11-6 3749
16
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 10204 6013
17
Testosterone enanthate Approved Phase 4 315-37-7 9416
18
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
19
Methyltestosterone Approved Phase 4 58-18-4 6010
20
Olmesartan Approved, Investigational Phase 4 144689-24-7, 144689-63-4 158781 130881
21
Spironolactone Approved Phase 4 52-01-7, 1952-01-7 5833
22
Saxagliptin Approved Phase 4 361442-04-8 11243969
23
Coenzyme Q10 Approved, Investigational, Nutraceutical Phase 4 303-98-0 5281915
24
Uric acid Investigational Phase 4 69-93-2 1175
25 carnitine Phase 4
26 Trace Elements Phase 4
27 Vitamins Phase 4
28 Nutrients Phase 4
29 Micronutrients Phase 4
30 Ubiquinone Phase 4
31 Antimetabolites Phase 4
32 Neurotransmitter Agents Phase 4
33 Adrenergic alpha-Antagonists Phase 4
34 Antioxidants Phase 4
35 Adrenergic alpha-1 Receptor Antagonists Phase 4
36 Protective Agents Phase 4
37 Calcium, Dietary Phase 4
38 calcium channel blockers Phase 4
39 Pharmaceutical Solutions Phase 4
40 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
41 Sodium Channel Blockers Phase 4
42 Natriuretic Peptide, Brain Phase 4
43 Cytochrome P-450 Enzyme Inhibitors Phase 4
44 Potassium Channel Blockers Phase 4
45 Cytochrome P-450 CYP3A Inhibitors Phase 4
46 Glucagon-Like Peptide 1 Phase 4
47 Testosterone 17 beta-cypionate Phase 4
48 Androgens Phase 4
49 Anabolic Agents Phase 4
50 Rosuvastatin Calcium Phase 4 147098-20-2

Interventional clinical trials:

(show top 50) (show all 297)
# Name Status NCT ID Phase Drugs
1 Prospective, Randomized Comparison of Therapy With Verapamil or Carvedilol on Long-Term Outcomes of Patients With Chronic Heart Failure Secondary to Non-Ischemic Cardiomyopathy Unknown status NCT00374465 Phase 4 Verapamil;Carvedilol
2 Prospective, Randomized Comparison of Therapy With Verapamil or Carvedilol on Long-Term Outcomes of Patients With Chronic Heart Failure Secondary to Non-Ischemic Cardiomyopathy Unknown status NCT00348530 Phase 4 Verapamil
3 Identification of Carnitine-responsive Cardiomyopathy and Myopathy in Adult Patients With Dilated and/or Hypertrophic Cardiomyopathy and Limb Girdle Weakness. Unknown status NCT01904396 Phase 4 Carnitine
4 A DANish Randomized, Controlled, Multicenter Study to Assess the Efficacy of Implantable Cardioverter Defibrillator in Patients With Non-ischemic Systolic Heart Failure on Mortality. The DANISH Study Unknown status NCT00541268 Phase 4
5 (MitraClip in Non-Responders to Cardiac Resynchronization Therapy) Unknown status NCT02592889 Phase 4
6 Effect of Coenzyme Q10 (Ubiquinone) Supplementation on Ventricular Function of Children With Idiopathic Dilated Cardiomyopathy.A Randomised Clinical Trial Completed NCT02115581 Phase 4 Coenzyme Q10;Placebo
7 Efficacy and Safety Study of Supramaximal Titrated Inhibition of RAAS in Idiopathic Dilated Cardiomyopathy Completed NCT01917149 Phase 4 Benazepril;Valsartan;Metoprolol
8 Beta-blocker Effect on Structural Remodeling and Gene Expression in the Failing Human Heart Completed NCT01798992 Phase 4 Carvedilol;Metoprolol succinate;Metoprolol succinate + doxazosin
9 Microvascular Dysfunction in Nonischemic Cardiomyopathy: Insights From CMR Assessment of Coronary Flow Reserve Completed NCT03249272 Phase 4 Regadenoson;Adenosine
10 A Multi-center, Randomized, Double, Placebo-controlled, Parallel Group Study of Improving Heart Function and Immunoregulation Effects of Qiliqiangxin Capsule in Patients With Dilated Cardiomyopathy Completed NCT01293903 Phase 4 Qiliqiangxin capsule;Placebo
11 Effect of Aldosterone on Energy Starvation in Heart Failure Completed NCT00574119 Phase 4 spironolactone
12 ACC - Atrial Contribution to CRT Completed NCT00180323 Phase 4
13 Phase 4. Study of Cardiac Resynchronization Therapy in Patients With Permanent Atrial Fibrillation. Completed NCT01181414 Phase 4 Beta blocker/digoxine/amiodarone
14 Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients Completed NCT00477789 Phase 4 allopurinol
15 Effects of Early Statin Treatment on Symptomatic Heart Failure and Ischemic Events After Acute Myocardial Infarction. The MUSASHI-AMI: A Multicenter Randomized Controlled Trial Completed NCT00128024 Phase 4 lipid-lowering treatment
16 Effect of the Angiotensin II Receptor Antagonist Irbesartan on Insulin Sensitivity and Metabolic Profile in Patients With Chronic Heart Failure Completed NCT00347087 Phase 4 Irbesartan
17 Effects of Testosterone on Myocardial Repolarization in Patients With Hypogonadism With/Without Chronic Heat Failure (NYHA Class I-II) Completed NCT03126656 Phase 4 Testosterone Undecanoate
18 A Randomized Trial of Carvedilol After Renin-angiotensin System Inhibition in Chronic Chagas Cardiomyopathy Completed NCT01557140 Phase 4 RASi plus carvedilol
19 Magnetic Resonance Assessment of Victoza Efficacy in the Regression of Cardiovascular Dysfunction In Type 2 Diabetes Mellitus Completed NCT01761318 Phase 4 Liraglutide;Liraglutide - Placebo
20 Pulse Reduction On Beta-blocker and Ivabradine Therapy Recruiting NCT02973594 Phase 4 Ivabradine;Placebo
21 Olmesartan Effect on Myocardial Viability of Patients With Dilated Cardiomyopathy Active, not recruiting NCT04174456 Phase 4 Olmesartan 20 Mg Oral Tablet
22 Evaluating the Effect of Spironolactone on Hypertrophic Cardiomyopathy-- a Multicenter Randomized Control Trial Not yet recruiting NCT02948998 Phase 4 Spironolactone
23 Effect of Saxagliptin Treatment on Myocardial Fat Content, Left Ventricular Function, and Monocyte Inflammation in Patients With Impaired Glucose Tolerance Terminated NCT01548651 Phase 4 Saxagliptin;Placebo
24 CArdiac Sarcoidosis Response TO steRoids (CASTOR) Trial Withdrawn NCT01210677 Phase 4 Prednisone
25 Regression of Fatty Heart by Valsartan Therapy Withdrawn NCT00745953 Phase 4 Valsartan;Hydrochlorothiazide
26 Impact of Continues Positive Airway Pressure Treatment in Patients With Dilated Cardiomyopathy and Obstructive Sleep Apnea (RIDA) Unknown status NCT02989181 Phase 3
27 Orodispersible Minitablets of Enalapril in Children With Heart Failure Due to Dilated Cardiomyopathy Unknown status NCT02652728 Phase 2, Phase 3 Enalapril Orodispersible Minitablet
28 Follow-up Safety Trial in Children With Chronic Heart Failure Therapy Receiving Orodispersible Minitablets of Enalapril Unknown status NCT02654678 Phase 2, Phase 3 Enalapril Orodispersible Minitablet
29 A Prospective, Placebo-controlled, Double-blind, Randomized Study to Compare Hydralazine-isosorbide-dinitrate(HYIS) Versus Placebo on Top of Std Care in African Patients With Acute Heart Failure (AHF) and Left Ventricular Dysfunction Unknown status NCT01822808 Phase 3 Hydralazine;Isosorbide Dinitrate
30 Orodispersible Minitablets of Enalapril in Young Children With Heart Failure Due to Congenital Heart Disease Unknown status NCT02652741 Phase 2, Phase 3 Enalapril Orodispersible Minitablet
31 Cardiovascular Health Investigation and Collaboration From Countries of America to Assess the Markers and Outcomes of Chagas Disease (CHICAMOCHA-3) - EQUITY (Equivalence of Usual Interventions for Trypanosomiasis) Unknown status NCT02369978 Phase 2, Phase 3 Nifurtimox;Benznidazole;Placebo
32 Honey Supplementation in Children With Idiopathic Dilated Cardiomyopathy: A Randomized Controlled Study Completed NCT02987322 Phase 2, Phase 3
33 Multicenter Randomized Study Of Cell Therapy In Cardiopathies - Dilated Cardiomyopathy Completed NCT00333827 Phase 3 optimal therapy for cardiaca failure
34 Autologous Transplantation of Bone Marrow Mononuclear Stem-Cells for Dilated Cardiomyopathy: Randomized Clinical Trial Completed NCT00743639 Phase 2, Phase 3
35 Effects of n-3 Polyunsaturated Fatty Acids (PUFAs) on Left Ventricular Function and Functional Capacity in Patients With Dilated Cardiomyopathy Completed NCT01223703 Phase 3 n-3 PUFAs;Placebo
36 Repetitive Intramyocardial CD34+ Cell Therapy in Dilated Cardiomyopathy Completed NCT02248532 Phase 2, Phase 3
37 A Phase III Study of the Effect of Rosuvastatin on Left Ventricular Remodeling and Inflammatory Markers in Heart Failure Completed NCT00505154 Phase 3 Rosuvastatin;placebo
38 A Randomized, Controlled Study to Evaluate the Safety and Cardiovascular Effects of Algisyl-LVR™ as a Method of Left Ventricular Augmentation in Patients With Dilated Cardiomyopathy (AUGMENT-HF) Completed NCT01311791 Phase 2, Phase 3 Standard medical therapy
39 The Acute Effects of the Angiotensin-converting Enzyme Inhibitor Enalaprilat on Flow Distribution After the Bidirectional Cavopulmonary Connection Completed NCT00741156 Phase 3 Enalaprilat
40 Carvedilol Effect in Preventing Chemotherapy - Induced Cardiotoxicity. A Randomized Double Blind Study. Completed NCT01724450 Phase 3 Carvedilol;Placebo
41 Effects of Growth Hormone on Exercise Capacity and Cardiopulmonary Performance in Patients With Chronic Heart Failure Completed NCT00501514 Phase 3 Growth hormone
42 Prevention of Left Ventricular Dysfunction With Enalapril and Carvedilol in Patients Submitted to Intensive Chemotherapy for the Treatment of Malignant Hemopathies Completed NCT01110824 Phase 3 Enalapril and carvedilol
43 Beta-Blocker Evaluation in Survival Trial (BEST) Completed NCT00000560 Phase 3 adrenergic beta antagonists
44 A Phase III, Double-blinded, Single Center, Randomized, Placebo Controlled Study to Assess the Safety, Tolerability, and Preliminary Efficacy of Single Intravenous Dose of Allogeneic Ischemia Tolerant Human Mesenchymal Bone Marrow Cells to Subjects With Acute Myocardial Infarction Completed NCT02672267 Phase 3
45 A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Hemodynamic and Clinical Effects of Natrecor (Nesiritide) Compared With Nitroglycerin Therapy for Symptomatic Decompensated CHF, The VMAC Trial: Vasodilation in the Management of Acute Congestive Heart Failure Completed NCT00270374 Phase 3 nesiritide
46 Prospective Evaluation Of Biventricular Pacing In Patients With Left Ventricular Dysfunction After Cardiovascular Surgery Completed NCT00321295 Phase 3
47 A Phase 3, Multinational, Randomized, Placebo-Controlled Study of ARRY-371797 in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation Recruiting NCT03439514 Phase 3 ARRY-371797
48 Resveratrol: A Potential Anti- Remodeling Agent in Heart Failure, From Bench to Bedside (RES-HF) Recruiting NCT01914081 Phase 3
49 Bisoprolol for Early Cardiomyopathy in Duchenne Muscular Dystrophy: a Randomized, Controlled Trial Recruiting NCT03779646 Phase 2, Phase 3 Bisoprolol Fumarate
50 PHOspholamban RElated CArdiomyopathy STudy - Intervention (Efficacy Study of Eplerenone in Presymptomaticphospholamban R14del Carriers) Active, not recruiting NCT01857856 Phase 3 Eplerenone

Search NIH Clinical Center for Dilated Cardiomyopathy

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Inamrinone
inamrinone lactate

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Dilated Cardiomyopathy cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Dilated Cardiomyopathy:
Autologous bone marrow-derived stem cells for treatment of dilated cardiomyopathy
Bone marrow-derived hematopoietic stem cells for treatment of pediatric dilated cardiomyopathy
Bone marrow-derived mesenchymal stem cells for treatment of heart diseases
Bone marrow-derived mononuclear cells for myocardial infarction
Enriched bone marrow-derived progenitor cells for heart diseases
Ixmyelocel-T, mesenchymal stem cells and monocytes for dilated cardiomyopathy
Peripheral blood-derived CD34+ stem cells for treatment of dilated cardiomyopathy
Umbilical cord-derived mesenchymal stem cells for treatment of dilated cardiomyopathy
Embryonic/Adult Cultured Cells Related to Dilated Cardiomyopathy:
Bone marrow-derived mononuclear cells
Bone marrow-derived hematopoietic stem cells (family)
Bone marrow-derived mesenchymal stem cells PMIDs: 22940024
Bone marrow-derived mononuclear cells PMIDs: 22834565
Bone marrow-derived mononuclear cells PMIDs: 22834565
Bone marrow-derived progenitor cells PMIDs: 16990385 22651868 16990384 18794392 22936827 23362308
Bone marrow-derived mesenchymal stem cells and monocytes (Ixmyelocel-T) PMIDs: 22453769 22776246
Peripheral blood-derived CD34+ cells PMIDs: 23065358
Umbilical cord-derived mesenchymal stem cells (family)

Cochrane evidence based reviews: cardiomyopathy, dilated

Sources

Genetic Tests for Dilated Cardiomyopathy

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Genetic tests related to Dilated Cardiomyopathy:

# Genetic test Affiliating Genes
1 Primary Dilated Cardiomyopathy 29 ABCC9 ACTC1 ACTN2 ANKRD1 BAG3 CSRP3 DES DSG2 EYA4 FKTN LDB3 LMNA MYBPC3 MYH6 NEXN PLN PSEN1 PSEN2 RBM20 SGCD TAZ TCAP TMPO TNNT2 TPM1 TTN VCL
2 Dilated Cardiomyopathy 29
3 Familial Dilated Cardiomyopathy 29
Sources

Anatomical Context for Dilated Cardiomyopathy

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MalaCards organs/tissues related to Dilated Cardiomyopathy:

40
Heart, Bone, Testes, Bone Marrow, Endothelial, T Cells, Skeletal Muscle
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Dilated Cardiomyopathy:
# Tissue Anatomical CompartmentCell Relevance
1 Heart Myocardium Cardiomyocytes Affected by disease
2 Heart Left Ventricle Cardiomyocytes Affected by disease, potential therapeutic candidate
3 Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Potential therapeutic candidate
4 Blood Cord Blood Mesenchymal Stem Cells Potential therapeutic candidate
Sources

Publications for Dilated Cardiomyopathy

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Articles related to Dilated Cardiomyopathy:

(show top 50) (show all 16612)
# Title Authors PMID Year
1
Dilated Cardiomyopathy Overview 6 61
20301486 2007
2
Cardiomyopathy, familial dilated. 61 6
16839424 2006
3
Multigenic Disease and Bilineal Inheritance in Dilated Cardiomyopathy Is Illustrated in Nonsegregating LMNA Pedigrees. 61 24
30012837 2018
4
The Rationale and Timing of Molecular Genetic Testing for Dilated Cardiomyopathy. 24 61
26518443 2015
5
A novel human R25C-phospholamban mutation is associated with super-inhibition of calcium cycling and ventricular arrhythmia. 24 61
25852082 2015
6
Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease. 61 24
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7
The landscape of genetic variation in dilated cardiomyopathy as surveyed by clinical DNA sequencing. 61 24
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8
Dilated cardiomyopathy: the complexity of a diverse genetic architecture. 61 24
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9
Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy. 24 61
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10
Truncations of titin causing dilated cardiomyopathy. 24 61
22335739 2012
11
HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). 6
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Update 2011: clinical and genetic issues in familial dilated cardiomyopathy. 24 61
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13
Clinical and genetic issues in dilated cardiomyopathy: a review for genetics professionals. 61 24
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14
Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy. 61 46
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15
Rare variant mutations in pregnancy-associated or peripartum cardiomyopathy. 61 24
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16
Peripartum cardiomyopathy as a part of familial dilated cardiomyopathy. 61 24
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17
The genetics of dilated cardiomyopathy. 24 61
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18
Coding sequence rare variants identified in MYBPC3, MYH6, TPM1, TNNC1, and TNNI3 from 312 patients with familial or idiopathic dilated cardiomyopathy. 61 24
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19
Use of genetics in the clinical evaluation of cardiomyopathy. 61 24
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20
Progress with genetic cardiomyopathies: screening, counseling, and testing in dilated, hypertrophic, and arrhythmogenic right ventricular dysplasia/cardiomyopathy. 24 61
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21
Left-dominant arrhythmogenic cardiomyopathy: an under-recognized clinical entity. 61 24
19095136 2008
22
Coding sequence mutations identified in MYH7, TNNT2, SCN5A, CSRP3, LBD3, and TCAP from 313 patients with familial or idiopathic dilated cardiomyopathy. 61 24
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23
Dilated cardiomyopathy presenting during fetal life. 24 61
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Clinical and genetic issues in familial dilated cardiomyopathy. 24 61
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25
Genetic evaluation of cardiomyopathy: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG). 24
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Use and interpretation of genetic tests in cardiovascular genetics. 24
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27
The p.G154S mutation of the alpha-B crystallin gene (CRYAB) causes late-onset distal myopathy. 54 61
20171888 2010
28
Heart failure-associated changes in RNA splicing of sarcomere genes. 54 61
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29
Connexin 43 remodeling induced by LMNA gene mutation Glu82Lys in familial dilated cardiomyopathy with atrial ventricular block. 54 61
20497714 2010
30
A novel LMNA mutation (R189W) in familial dilated cardiomyopathy: evidence for a 'hot spot' region at exon 3: a case report. 61 54
20307303 2010
31
Familial dilated cardiomyopathy secondary to dystrophin splice site mutation. 54 61
20206892 2010
32
Dilated cardiomyopathy alters the expression patterns of CAR and other adenoviral receptors in human heart. 61 54
19957088 2010
33
Identification of a new lamin A/C mutation in a Chinese family affected with atrioventricular block as the prominent phenotype. 54 61
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34
Morphological analysis of 13 LMNA variants identified in a cohort of 324 unrelated patients with idiopathic or familial dilated cardiomyopathy. 54 61
20160190 2010
35
Prognostic value of tissue Doppler right ventricular systolic and diastolic function indexes combined with plasma B-type natriuretic Peptide in patients with advanced heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. 61 54
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36
Cardiac sodium channel Na(v)1.5 and interacting proteins: Physiology and pathophysiology. 54 61
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37
Reduced glucose transporter GLUT4 in skeletal muscle predicts insulin resistance in non-diabetic chronic heart failure patients independently of body composition. 54 61
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38
Mechanism of right precordial ST-segment elevation in structural heart disease: excitation failure by current-to-load mismatch. 61 54
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39
R25G mutation in exon 1 of LMNA gene is associated with dilated cardiomyopathy and limb-girdle muscular dystrophy 1B. 54 61
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40
Novel mutations in beta-myosin heavy chain, actin and troponin-I genes associated with dilated cardiomyopathy in Indian population. 61 54
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41
[LMNA gene and dilated cardiomyopathy]. 61 54
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42
The signal transduction cascade regulating the expression of the gap junction protein connexin43 by beta-adrenoceptors. 61 54
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Stress-induced dilated cardiomyopathy in a knock-in mouse model mimicking human titin-based disease. 61 54
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44
Stimulation of cardiac beta-adrenoceptors targets connexin 43. 61 54
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45
Clinical and functional characterization of TNNT2 mutations identified in patients with dilated cardiomyopathy. 61 54
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46
Validation of high-resolution DNA melting analysis for mutation scanning of the LMNA gene. 54 61
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47
Comprehensive mutation scanning of LMNA in 268 patients with lone atrial fibrillation. 54 61
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48
A novel mutation in the G4.5 (TAZ) gene in a Greek patient with Barth syndrome. 61 54
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Lamin A/C deficiency as a cause of familial dilated cardiomyopathy. 54 61
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50
Acute dilated cardiomyopathy in a patient with deficiency of long-chain 3-hydroxyacyl-CoA dehydrogenase. 54 61
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Sources

Variations for Dilated Cardiomyopathy

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ClinVar genetic disease variations for Dilated Cardiomyopathy:

6 (show top 50) (show all 1520) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 TTN NM_001267550.2(TTN):c.86363G>A (p.Trp28788Ter)SNV Pathogenic 419359 rs1064793814 2:179424496-179424496 2:178559769-178559769
2 TTN NM_001267550.2(TTN):c.51654C>G (p.Tyr17218Ter)SNV Pathogenic 429894 rs1131691655 2:179474496-179474496 2:178609769-178609769
3 TTN NM_001267550.2(TTN):c.82657G>T (p.Gly27553Ter)SNV Pathogenic 488810 rs869178171 2:179428202-179428202 2:178563475-178563475
4 DSP NM_004415.4(DSP):c.3474dup (p.Glu1159fs)duplication Pathogenic 517147 rs727503000 6:7579896-7579897 6:7579663-7579664
5 SCN5A NM_000335.5(SCN5A):c.1603C>T (p.Arg535Ter)SNV Pathogenic 517279 rs1417036453 3:38645490-38645490 3:38603999-38603999
6 LMNA NM_170707.4(LMNA):c.1494G>A (p.Trp498Ter)SNV Pathogenic 520447 rs57730570 1:156106909-156106909 1:156137118-156137118
7 TTN NM_001267550.2(TTN):c.90706G>T (p.Glu30236Ter)SNV Pathogenic 520476 rs974510652 2:179416921-179416921 2:178552194-178552194
8 TTN NM_001267550.2(TTN):c.51581G>A (p.Trp17194Ter)SNV Pathogenic 520481 rs1553692290 2:179474569-179474569 2:178609842-178609842
9 MYH6 NM_002471.3(MYH6):c.735T>G (p.Phe245Leu)SNV Pathogenic 520533 rs1263987728 14:23873505-23873505 14:23404296-23404296
10 TTN NM_001267550.2(TTN):c.47961del (p.Gly15988fs)deletion Pathogenic 523430 rs1553707780 2:179481655-179481655 2:178616928-178616928
11 NKX2-5 NM_004387.4(NKX2-5):c.711C>A (p.Tyr237Ter)SNV Pathogenic 523473 rs1554093433 5:172659836-172659836 5:173232833-173232833
12 DMD NM_004006.2(DMD):c.4838G>A (p.Trp1613Ter)SNV Pathogenic 523468 rs1557315928 X:32398634-32398634 X:32380517-32380517
13 subset of 81 genes: GNB1 GRCh37/hg19 1p36.33-36.31(chr1:834101-6076140)copy number loss Pathogenic 523269 1:834101-6076140
14 BAG3 NM_004281.3(BAG3):c.252_258dup (p.Pro87fs)duplication Pathogenic 560609 rs1564773559 10:121429432-121429433 10:119669920-119669921
15 CSRP3 NM_003476.5(CSRP3):c.420G>C (p.Trp140Cys)SNV Pathogenic 585278 rs1565050320 11:19206587-19206587 11:19185040-19185040
16 TTN NM_001267550.2(TTN):c.85295del (p.Leu28432fs)deletion Pathogenic 684873 2:179425564-179425564 2:178560837-178560837
17 TTN NM_001267550.2(TTN):c.72663del (p.Pro24223fs)deletion Pathogenic 684838 2:179438196-179438196 2:178573469-178573469
18 TTN , TTN-AS1 NM_001267550.2(TTN):c.81341dup (p.Asn27115fs)duplication Pathogenic 689590 2:179429517-179429518 2:178564790-178564791
19 RBM20 NM_001134363.3(RBM20):c.1901G>T (p.Arg634Leu)SNV Pathogenic 689585 10:112572056-112572056 10:110812298-110812298
20 TTN NM_001267550.2(TTN):c.91034G>A (p.Trp30345Ter)SNV Pathogenic 691676 2:179416593-179416593 2:178551866-178551866
21 TTN NM_001267550.2(TTN):c.64038T>G (p.Tyr21346Ter)SNV Pathogenic 691688 2:179451900-179451900 2:178587173-178587173
22 TTN NM_001267550.2(TTN):c.58838del (p.Tyr19613fs)deletion Pathogenic 691690 2:179458097-179458097 2:178593370-178593370
23 TTN NM_001267550.2(TTN):c.51436C>T (p.Gln17146Ter)SNV Pathogenic 691694 2:179474817-179474817 2:178610090-178610090
24 LMNA NM_170707.4(LMNA):c.711_729delinsCC (p.Glu238fs)indel Pathogenic 691647 1:156104667-156104685 1:156134876-156134894
25 TNNI3 NM_000363.5(TNNI3):c.24+2T>ASNV Pathogenic 691809 19:55668662-55668662 19:55157294-55157294
26 MYH7 NM_000257.4(MYH7):c.5655+5G>CSNV Pathogenic 694311 14:23883211-23883211 14:23414002-23414002
27 TTN NM_001267550.2(TTN):c.54327del (p.Lys18110fs)deletion Pathogenic 694575 2:179469489-179469489 2:178604762-178604762
28 RBM20 NM_001134363.3(RBM20):c.150_153del (p.Pro52fs)deletion Pathogenic 694560 10:112404362-112404365 10:110644604-110644607
29 TTN NM_001267550.2(TTN):c.73828_73835del (p.Val24611fs)deletion Pathogenic 694571 2:179437024-179437031 2:178572297-178572304
30 RBM20 NM_001134363.3(RBM20):c.1913C>T (p.Pro638Leu)SNV Pathogenic 268 rs267607003 10:112572068-112572068 10:110812310-110812310
31 MYBPC3 NM_000256.3(MYBPC3):c.1624G>C (p.Glu542Gln)SNV Pathogenic 8608 rs121909374 11:47364129-47364129 11:47342578-47342578
32 SCN5A NM_001160160.2(SCN5A):c.4714+66G>CSNV Pathogenic 9406 rs137854607 3:38595800-38595800 3:38554309-38554309
33 TNNT2 NM_001276345.2(TNNT2):c.451C>T (p.Arg151Trp)SNV Pathogenic 12414 rs74315379 1:201333464-201333464 1:201364336-201364336
34 PLN NM_002667.5(PLN):c.25C>T (p.Arg9Cys)SNV Pathogenic 13636 rs111033559 6:118880109-118880109 6:118558946-118558946
35 MYH7 NM_000257.4(MYH7):c.1594T>C (p.Ser532Pro)SNV Pathogenic 14108 rs121913642 14:23897088-23897088 14:23427879-23427879
36 LMNA NM_170707.4(LMNA):c.16C>T (p.Gln6Ter)SNV Pathogenic 14477 rs61046466 1:156084725-156084725 1:156114934-156114934
37 LMNA NM_170707.4(LMNA):c.585C>G (p.Asn195Lys)SNV Pathogenic 14483 rs28933091 1:156104265-156104265 1:156134474-156134474
38 LMNA NM_170707.4(LMNA):c.608A>G (p.Glu203Gly)SNV Pathogenic 14484 rs28933092 1:156104288-156104288 1:156134497-156134497
39 LMNA NM_170707.4(LMNA):c.1824C>T (p.Gly608=)SNV Pathogenic 14500 rs58596362 1:156108404-156108404 1:156138613-156138613
40 TPM1 NM_001018005.2(TPM1):c.688G>A (p.Asp230Asn)SNV Pathogenic 31884 rs199476317 15:63354462-63354462 15:63062263-63062263
41 SCN5A NM_000335.5(SCN5A):c.665G>A (p.Arg222Gln)SNV Pathogenic 39444 rs45546039 3:38655272-38655272 3:38613781-38613781
42 TAZ NM_000116.5(TAZ):c.718G>C (p.Gly240Arg)SNV Pathogenic 42266 rs387907218 X:153649015-153649015 X:154420676-154420676
43 MYBPC3 NM_000256.3(MYBPC3):c.2096del (p.Pro699fs)deletion Pathogenic 42596 rs397515947 11:47360927-47360927 11:47339376-47339376
44 MYBPC3 NM_000256.3(MYBPC3):c.551dup (p.Lys185fs)duplication Pathogenic 42771 rs397516059 11:47371427-47371428 11:47349876-47349877
45 TNNT2 NM_001276345.2(TNNT2):c.422G>A (p.Arg141Gln)SNV Pathogenic 43637 rs397516464 1:201333493-201333493 1:201364365-201364365
46 DES NM_001927.4(DES):c.38C>T (p.Ser13Phe)SNV Pathogenic 44260 rs62636495 2:220283222-220283222 2:219418500-219418500
47 PLN NM_002667.5(PLN):c.37_39AGA[1] (p.Arg14del)short repeat Pathogenic 44580 rs397516784 6:118880120-118880122 6:118558957-118558959
48 DSP NM_004415.4(DSP):c.1146del (p.Phe382fs)deletion Pathogenic 44852 rs397516913 6:7568014-7568014 6:7567781-7567781
49 LMNA NM_005572.3(LMNA):c.1526dupC (p.Thr510Tyrfs)duplication Pathogenic 48041 rs58013325 1:156106935-156106936 1:156137144-156137145
50 LMNA NM_170707.4(LMNA):c.348dup (p.Lys117fs)duplication Pathogenic 48061 rs267607646 1:156085056-156085057 1:156115265-156115266
Sources

Expression for Dilated Cardiomyopathy

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Search GEO for disease gene expression data for Dilated Cardiomyopathy.
Sources

Pathways for Dilated Cardiomyopathy

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Pathways related to Dilated Cardiomyopathy according to KEGG:

36
# Name Kegg Source Accession
1 Dilated cardiomyopathy (DCM) hsa05414

Pathways related to Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Cardiac conduction 65
Show member pathways
 12.62 TTN TPM1 TNNT2 TNNI3 SCN5A PLN
2
cGMP-PKG signaling pathway 36
Show member pathways
 12.37 TPM1 TNNT2 TNNI3 SCN5A PLN MYH7
3
Cytoskeletal Signaling 4
12.34 TPM1 TNNT2 TNNI3 LMNA DES
4
Arrhythmogenic right ventricular cardiomyopathy (ARVC) 36
Show member pathways
 11.92 LMNA DSP DSG2 DMD DES ACTN2
5
Thyroid hormone signaling pathway 36
11.75 PLN MYH7 MYH6
6
Cardiac muscle contraction 36
11.71 TPM1 TNNT2 TNNI3 MYH7 MYH6
7
Mesenchymal Stem Cells and Lineage-specific Markers 64
11.63 TNNT2 TNNI3 DES
8
Dilated cardiomyopathy (DCM) 36
Show member pathways
 11.63 TTN TPM1 TNNT2 TNNI3 PLN MYH7
9
Antiarrhythmic Pathway, Pharmacodynamics 60
11.48 SCN5A PLN LMNA DSP
10
Striated Muscle Contraction 65 1
11.47 TTN TPM1 TNNT2 TNNI3 MYH6 MYBPC3
11
Cardiac Progenitor Differentiation 1
11.43 TNNT2 TNNI3 SCN5A MYH6
Sources

GO Terms for Dilated Cardiomyopathy

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Cellular components related to Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 sarcolemma GO:0042383 9.71 SCN5A DMD DES
2 stress fiber GO:0001725 9.67 TPM1 MYH7 MYH6 BAG3
3 myofibril GO:0030016 9.65 TPM1 TNNI3 MYH7 MYH6 DMD
4 lateral plasma membrane GO:0016328 9.63 SCN5A DSG2 DMD
5 intercalated disc GO:0014704 9.62 SCN5A DSP DSG2 DES
6 Z disc GO:0030018 9.61 TTN SCN5A MYH7 MYH6 DMD DES
7 myosin filament GO:0032982 9.58 MYH7 MYH6 MYBPC3
8 contractile fiber GO:0043292 9.55 TNNI3 DES
9 muscle myosin complex GO:0005859 9.52 MYH7 MYH6
10 striated muscle thin filament GO:0005865 9.51 TTN TNNT2
11 fascia adherens GO:0005916 9.49 DSP DES
12 troponin complex GO:0005861 9.48 TNNT2 TNNI3
13 cardiac myofibril GO:0097512 9.46 TNNT2 TNNI3 MYBPC3 DES
14 cardiac Troponin complex GO:1990584 9.43 TNNT2 TNNI3
15 sarcomere GO:0030017 9.28 TTN TPM1 TNNT2 TNNI3 MYH7 MYH6

Biological processes related to Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.92 TNNI3 TAZ RBM20 CSRP3
2 platelet degranulation GO:0002576 9.84 TTN LAMP2 ACTN2
3 cellular calcium ion homeostasis GO:0006874 9.83 TNNI3 PLN CSRP3
4 muscle contraction GO:0006936 9.81 TTN TPM1 TNNT2 TNNI3 TAZ MYH7
5 sarcomere organization GO:0045214 9.8 TTN TPM1 TNNT2 MYH6 CSRP3 ACTN2
6 skeletal muscle tissue development GO:0007519 9.77 TAZ DMD CSRP3
7 regulation of heart contraction GO:0008016 9.77 TPM1 TNNT2 PLN MYH6 DES
8 regulation of heart rate GO:0002027 9.76 SCN5A MYH7 MYH6 DMD
9 positive regulation of ATPase activity GO:0032781 9.73 TPM1 TNNT2 MYBPC3
10 regulation of the force of heart contraction GO:0002026 9.73 PLN MYH7 MYH6 CSRP3
11 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.73 TPM1 TNNT2 TNNI3 MYH7 MYH6 MYBPC3
12 regulation of heart rate by cardiac conduction GO:0086091 9.72 SCN5A DSP DSG2
13 skeletal muscle contraction GO:0003009 9.71 TNNT2 TNNI3 MYH7
14 striated muscle contraction GO:0006941 9.71 TTN TNNI3 MYH7 MYH6
15 cardiac muscle tissue development GO:0048738 9.7 TAZ PLN CSRP3
16 muscle cell cellular homeostasis GO:0046716 9.69 LAMP2 DMD BAG3
17 regulation of muscle contraction GO:0006937 9.67 TPM1 TNNT2 TNNI3
18 intermediate filament organization GO:0045109 9.66 DSP DES
19 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.65 PLN DMD
20 cardiac myofibril assembly GO:0055003 9.65 TTN CSRP3
21 negative regulation of ATPase activity GO:0032780 9.65 TNNT2 TNNI3 PLN
22 muscle filament sliding GO:0030049 9.65 TTN TPM1 TNNT2 TNNI3 MYH7 MYH6
23 cardiac muscle hypertrophy in response to stress GO:0014898 9.64 MYH7 MYH6
24 adult heart development GO:0007512 9.64 MYH7 MYH6
25 regulation of cardiac muscle cell contraction GO:0086004 9.63 SCN5A PLN
26 cardiac muscle fiber development GO:0048739 9.63 TTN MYH6
27 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.62 DSP DSG2
28 response to denervation involved in regulation of muscle adaptation GO:0014894 9.61 SCN5A DMD
29 cardiac muscle hypertrophy GO:0003300 9.61 TTN CSRP3
30 chaperone-mediated autophagy GO:0061684 9.6 LAMP2 BAG3
31 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.58 DSP DSG2
32 desmosome organization GO:0002934 9.58 DSP DSG2
33 detection of muscle stretch GO:0035995 9.57 TTN CSRP3
34 cardiac muscle contraction GO:0060048 9.36 TTN TPM1 TNNT2 TNNI3 TAZ SCN5A

Molecular functions related to Dilated Cardiomyopathy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.48 TTN TPM1 TNNT2 TNNI3 SCN5A PLN
2 identical protein binding GO:0042802 10 TTN TPM1 PLN MYBPC3 DES CSRP3
3 protein domain specific binding GO:0019904 9.81 TNNI3 SCN5A LAMP2 ACTN2
4 calmodulin binding GO:0005516 9.73 TTN SCN5A MYH7 MYH6
5 cytoskeletal protein binding GO:0008092 9.65 TPM1 DES ACTN2
6 actin filament binding GO:0051015 9.63 TTN TPM1 TNNI3 MYH7 MYH6 ACTN2
7 actin binding GO:0003779 9.61 TPM1 TNNT2 TNNI3 MYH7 MYH6 MYBPC3
8 structural constituent of cytoskeleton GO:0005200 9.56 TPM1 DSP DMD DES
9 nitric-oxide synthase binding GO:0050998 9.54 SCN5A DMD
10 titin binding GO:0031432 9.52 MYBPC3 ACTN2
11 actinin binding GO:0042805 9.49 TTN CSRP3
12 telethonin binding GO:0031433 9.4 TTN CSRP3
13 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 9.37 DSP DSG2
14 troponin C binding GO:0030172 9.32 TNNT2 TNNI3
15 structural constituent of muscle GO:0008307 9.1 TTN TPM1 MYBPC3 DMD CSRP3 ACTN2
Sources

Sources for Dilated Cardiomyopathy

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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