MCID: DPT001
MIFTS: 31

Dipetalonemiasis

Categories: Blood diseases, Infectious diseases, Neuronal diseases, Rare diseases, Skin diseases
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Aliases & Classifications for Dipetalonemiasis

MalaCards integrated aliases for Dipetalonemiasis:

Name: Dipetalonemiasis 11 19 14 16
Dipetalonema Infections 19 43 71
Acanthocheilonemiasis 19 75 71
Acanthocheilonema Perstans Infection 19 71
Infection by Dipetalonema Perstans 11
Dipetalonema Infectious Disease 11
Infection by Dipetalonema 11
Mansonella Perstans 19

Classifications:



External Ids:

Disease Ontology 11 DOID:14422
ICD9CM 34 125.4
MeSH 43 D004154
NCIt 49 C34540
SNOMED-CT 68 15629006
UMLS 71 C0012517 C1527287 C3489414

Summaries for Dipetalonemiasis

Disease Ontology: 11 A filariasis that is a zoonotic infection caused by the nematode of the genus Dipetalonema, which is transmitted accidentally to humans from porcupines, beavers and other mammals by mosquitoes. The adult worms live subcutaneously or in body cavities or in the eyes of humans. Dead worms cause hypersensitivity necrosis with eosinophils, followed by granulomatous reaction and fibrosis.

MalaCards based summary: Dipetalonemiasis, also known as dipetalonema infections, is related to volvulus of midgut and ascaris lumbricoides infection. An important gene associated with Dipetalonemiasis is GPT (Glutamic--Pyruvic Transaminase). The drugs Doxycycline and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, salivary gland and bone marrow.

GARD: 19 A parasitic infection caused by genus of filarial worms called Dipetalonema. It produces microfilariae in the blood and body fluids.

Wikipedia: 75 Acanthocheilonemiasis is a rare tropical infectious disease caused by a parasite known as... more...

Related Diseases for Dipetalonemiasis

Diseases related to Dipetalonemiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 volvulus of midgut 31.0 GPT ALB
2 ascaris lumbricoides infection 30.2 GPT ALB
3 trypanosomiasis 30.1 GPT ALB
4 malaria 29.8 MT-CO1 GPT ALB
5 filariasis 29.8 MT-CO1 ALB
6 mansonelliasis 11.7
7 loiasis 11.4
8 hypereosinophilic syndrome 10.5
9 parkinson disease, late-onset 10.3
10 buruli ulcer 10.3
11 angioedema 10.3
12 cytokine deficiency 10.3
13 twin-reversed arterial perfusion sequence 10.3
14 oculodentodigital dysplasia 10.1
15 glycogen storage disease v 10.1
16 sleeping sickness 10.1
17 strongyloidiasis 10.1
18 plasmodium falciparum malaria 10.1
19 hypogonadism 10.1
20 necatoriasis 10.1
21 amebiasis 10.1
22 hydrocele 10.1
23 oto-palatal-digital syndrome 10.1
24 nutmeg liver 10.0 GPT ALB
25 klebsiella pneumonia 10.0 GPT ALB
26 pneumonia 10.0 GPT ALB
27 heterophyiasis 10.0 GPT ALB
28 hepatic tuberculosis 10.0 GPT ALB
29 acalculous cholecystitis 10.0 GPT ALB
30 cholecystitis 10.0 GPT ALB
31 hepatic infarction 10.0 GPT ALB
32 splenic abscess 10.0 GPT ALB
33 ascending cholangitis 10.0 GPT ALB
34 cholangitis 10.0 GPT ALB
35 hydrops of gallbladder 10.0 GPT ALB
36 peliosis hepatis 10.0 GPT ALB
37 granulomatous hepatitis 10.0 GPT ALB
38 suppurative cholangitis 10.0 GPT ALB
39 early congenital syphilis 10.0 GPT ALB
40 syphilis 10.0 GPT ALB
41 hepatic coma 10.0 GPT ALB
42 mesenteric lymphadenitis 10.0 GPT ALB
43 ankylosing spondylitis 1 10.0 GPT ALB
44 hemoglobin d disease 10.0 GPT ALB
45 gastrointestinal tuberculosis 10.0 GPT ALB
46 duodenal obstruction 10.0 GPT ALB
47 acute cholangitis 10.0 GPT ALB
48 abdominal tuberculosis 10.0 GPT ALB
49 bacterial conjunctivitis 10.0 GPT ALB
50 paralytic ileus 10.0 GPT ALB

Graphical network of the top 20 diseases related to Dipetalonemiasis:



Diseases related to Dipetalonemiasis

Symptoms & Phenotypes for Dipetalonemiasis

Drugs & Therapeutics for Dipetalonemiasis

Drugs for Dipetalonemiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
2 Anti-Bacterial Agents Phase 2
3 Antiprotozoal Agents Phase 2
4 Antimalarials Phase 2
5
Ivermectin Approved, Investigational, Vet_approved 70288-86-7 9812710 6427057
6
Albendazole Approved, Vet_approved 54965-21-8 2082
7
BCG vaccine Approved, Investigational
8 Antimitotic Agents
9 Tubulin Modulators
10 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in Subjects With Schistosomiasis: A Pilot Study Withdrawn NCT02734186 Phase 4 Praziquantel
2 Comparison of Early and Late Administration of Doxycycline in Their Efficacy Against Mansonella Perstans and in Development of Immunity Against Mycobacterial Infections Completed NCT02281643 Phase 2 Doxycycline
3 Treatment of Mansonella Perstans Infection in an Area Coendemic for Lymphatic Filariasis: A Pilot Study of the Effects of Doxycycline Completed NCT00340691 Phase 2 Doxycycline
4 Studies on the Epidemiology and Control of Mansonella Perstans Infection in Uganda Completed NCT00215280 ivermectin and albendazole
5 Mansonella Perstans Effects on BCG Vaccine-induced Protection Against Childhood Tuberculosis (TB) as Well as TB Disease Severity and Recovery in Cameroon (MAP-TB) Recruiting NCT04547738 TB treatment according to national guidelines

Search NIH Clinical Center for Dipetalonemiasis

Cochrane evidence based reviews: dipetalonema infections

Genetic Tests for Dipetalonemiasis

Anatomical Context for Dipetalonemiasis

Organs/tissues related to Dipetalonemiasis:

MalaCards : Skin, Salivary Gland, Bone Marrow, T Cells, Eye, Lung, Bone

Publications for Dipetalonemiasis

Articles related to Dipetalonemiasis:

(show top 50) (show all 216)
# Title Authors PMID Year
1
Integrated xenosurveillance of Loa loa, Wuchereria bancrofti, Mansonella perstans and Plasmodium falciparum using mosquito carcasses and faeces: A pilot study in Cameroon. 62
36322515 2022
2
A large case series of travel-related Mansonella perstans (vector-borne filarial nematode): a TropNet study in Europe. 62
35417002 2022
3
Prevalence and risk factors for blood filariasis among HIV-infected adults in Gabon, Central Africa: a pilot study. 62
35474144 2022
4
Prevalence, probability, and characteristics of malaria and filariasis co-infections: A systematic review and meta-analysis. 62
36269701 2022
5
Misleading eosinophil counts in migration-associated malaria: do not miss hidden helminthic co-infections. 62
35934309 2022
6
Comparison of three PCR-based methods to detect Loa loa and Mansonella perstans in long-term frozen storage dried blood spots. 62
35653502 2022
7
Performance of Field's Stain Compared with Conventional Giemsa Stain for the Rapid Detection of Blood Microfilariae in Gabon. 62
35895407 2022
8
Human Filariasis in Travelers and Migrants: A Retrospective 25-year Analysis at the Institute of Tropical Medicine, Antwerp, Belgium. 62
34463732 2022
9
Doxycycline treatment of Mansonella perstans infected individuals affects immune cell activation and causes long-term T-cell polarization. 62
35657028 2022
10
Circulating IL-6, IL-10, and TNF-alpha and IL-10/IL-6 and IL-10/TNF-alpha ratio profiles of polyparasitized individuals in rural and urban areas of gabon. 62
35421083 2022
11
Colorimetric and Real-Time Loop-Mediated Isothermal Amplification (LAMP) for Detection of Loa loa DNA in Human Blood Samples. 62
35626235 2022
12
Characterising co-infections with Plasmodium spp., Mansonella perstans or Loa loa in asymptomatic children, adults and elderly people living on Bioko Island using nucleic acids extracted from malaria rapid diagnostic tests. 62
35100277 2022
13
Molecular Detection and Characterization of Intestinal and Blood Parasites in Wild Chimpanzees (Pan troglodytes verus) in Senegal. 62
34828022 2021
14
Assessment of the burden of malaria and bacteraemia by retrospective molecular diagnosis in febrile illnesses and first-line anti-infectives in Côte d'Ivoire. 62
34146685 2021
15
Diagnostic performance of capillary and venous blood samples in the detection of Loa loa and Mansonella perstans microfilaraemia using light microscopy. 62
34398886 2021
16
Urine metabolites for the identification of Onchocerca volvulus infections in patients from Cameroon. 62
34380554 2021
17
Preliminary comparison between an in-house real-time PCR vs microscopy for the diagnosis of Loa loa and Mansonella perstans. 62
33484727 2021
18
Molecular Epidemiology of Mansonella Species in Gabon. 62
33099649 2021
19
Limitations of PCR detection of filarial DNA in human stools from subjects non-infected with soil-transmitted helminths. 62
34047694 2021
20
Individual risk of post-ivermectin serious adverse events in subjects infected with Loa loa. 62
33294807 2020
21
Deep Sequencing Reveals Occult Mansonellosis Coinfections in Residents From the Brazilian Amazon Village of São Gabriel da Cachoeira. 62
31995172 2020
22
Imported Mansonella perstans infection in Spain. 62
32703283 2020
23
Complete Mitochondrial Genome Sequence of Mansonella perstans. 62
32703831 2020
24
Parasitic Infections in African Humans and Non-Human Primates. 62
32664573 2020
25
Detection of DNA of filariae closely related to Mansonella perstans in faecal samples from wild non-human primates from Cameroon and Gabon. 62
32546281 2020
26
Field evaluation of DNA detection of human filarial and malaria parasites using mosquito excreta/feces. 62
32267840 2020
27
Dataset on in vitro maintenance of Mansonella perstans microfilariae and drug testing. 62
31886361 2020
28
High Circulation of Malaria and Low Prevalence of Bacteremia in Febrile and Afebrile Children in Northeastern Gabon. 62
31769404 2020
29
In vitro maintenance of Mansonella perstans microfilariae and its relevance for drug screening. 62
31580876 2019
30
The Efficacy of Doxycycline Treatment on Mansonella perstans Infection: An Open-Label, Randomized Trial in Ghana. 62
31162017 2019
31
In Silico Identification of Novel Biomarkers and Development of New Rapid Diagnostic Tests for the Filarial Parasites Mansonella perstans and Mansonella ozzardi. 62
31311985 2019
32
Update on the biology and ecology of Culicoides species in the South-West region of Cameroon with implications on the transmission of Mansonella perstans. 62
30975194 2019
33
Laboratory Parameters after Treatment for Loa loa and Mansonella perstans: The Experience of a Single Referral Center for Tropical Diseases in a Non-Endemic Area. 62
30693861 2019
34
Inflammatory and regulatory CCL and CXCL chemokine and cytokine cellular responses in patients with patent Mansonella perstans filariasis. 62
30561772 2019
35
Application of metagenomic shotgun sequencing to detect vector-borne pathogens in clinical blood samples. 62
31577814 2019
36
Factors Associated with Wuchereria bancrofti Microfilaremia in an Endemic Area of Mali. 62
29714157 2018
37
Comparison of PCR Methods for Onchocerca volvulus Detection in Skin Snip Biopsies from the Tshopo Province, Democratic Republic of the Congo. 62
29611501 2018
38
Mansonella perstans, Onchocerca volvulus and Strongyloides stercoralis infections in rural populations in central and southern Togo. 62
29774301 2018
39
Geographical distribution and species identification of human filariasis and onchocerciasis in Bioko Island, Equatorial Guinea. 62
29289559 2018
40
Familial Aggregation and Heritability of Loa loa Microfilaremia. 62
29040446 2018
41
Mansonella perstans microfilaremic individuals are characterized by enhanced type 2 helper T and regulatory T and B cell subsets and dampened systemic innate and adaptive immune responses. 62
29324739 2018
42
Mansonellosis: current perspectives. 62
30050351 2018
43
Mapping the geographical distribution of podoconiosis in Cameroon using parasitological, serological, and clinical evidence to exclude other causes of lymphedema. 62
29324858 2018
44
Prevalence of and risk factors for malaria, filariasis, and intestinal parasites as single infections or co-infections in different settlements of Gabon, Central Africa. 62
29378644 2018
45
A cross-sectional study of the filarial and Leishmania co-endemicity in two ecologically distinct settings in Mali. 62
29310700 2018
46
Successful long-term maintenance of Mansonella perstans in an in vitro culture system. 62
29126431 2017
47
Imported Infections with Mansonella perstans Nematodes, Italy. 62
28820369 2017
48
Validation of onchocerciasis biomarker N-acetyltyramine-O-glucuronide (NATOG). 62
28600214 2017
49
Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung. 62
28486498 2017
50
Successful treatment of 2 imported cases of Mansonella perstans infection. 62
28542192 2017

Variations for Dipetalonemiasis

Expression for Dipetalonemiasis

Search GEO for disease gene expression data for Dipetalonemiasis.

Pathways for Dipetalonemiasis

GO Terms for Dipetalonemiasis

Molecular functions related to Dipetalonemiasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pyridoxal phosphate binding GO:0030170 8.92 GPT ALB

Sources for Dipetalonemiasis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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