Dipetalonemiasis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Dipetalonemiasis

MalaCards integrated aliases for Dipetalonemiasis:

Name: Dipetalonemiasis ¹² ²⁰ ¹⁵ ¹⁷

Dipetalonema Infections ²⁰ ⁴⁴ ⁷⁰

Acanthocheilonema Perstans Infection ²⁰ ⁷⁰

Acanthocheilonemiasis ²⁰ ⁷⁰

Infection by Dipetalonema Perstans ¹²

Dipetalonema Infectious Disease ¹²

Infection by Dipetalonema ¹²

Mansonella Perstans ²⁰

Classifications:

MalaCards categories:
Global: Rare diseases Infectious diseases
Anatomical: Skin diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:14422

ICD9CM ³⁴ 125.4

MeSH ⁴⁴ D004154

NCIt ⁵⁰ C34540

SNOMED-CT ⁶⁷ 15629006

EFO ¹⁷ EFO_0007237

UMLS ⁷⁰ C0012517 C1527287 C3489414

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Summaries for Dipetalonemiasis

Disease Ontology : ¹² A filariasis that is a zoonotic infection caused by the nematode of the genus Dipetalonema, which is transmitted accidentally to humans from porcupines, beavers and other mammals by mosquitoes. The adult worms live subcutaneously or in body cavities or in the eyes of humans. Dead worms cause hypersensitivity necrosis with eosinophils, followed by granulomatous reaction and fibrosis.

MalaCards based summary : Dipetalonemiasis, also known as dipetalonema infections, is related to volvulus of midgut and trypanosomiasis. An important gene associated with Dipetalonemiasis is GPT (Glutamic--Pyruvic Transaminase). The drugs Doxycycline and Antimalarials have been mentioned in the context of this disorder.

Wikipedia : ⁷³ Acanthocheilonemiasis is a rare tropical infectious disease caused by a parasite known as... more...

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Related Diseases for Dipetalonemiasis

Diseases related to Dipetalonemiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 171)

#	Related Disease	Score	Top Affiliating Genes
1	volvulus of midgut	31.0	GPT ALB
2	trypanosomiasis	30.1	GPT ALB
3	mansonelliasis	11.7
4	loiasis	10.6
5	onchocerciasis	10.5
6	hypereosinophilic syndrome	10.5
7	filarial elephantiasis	10.5
8	triiodothyronine receptor auxiliary protein	10.3
9	buruli ulcer	10.3
10	angioedema	10.3
11	cytokine deficiency	10.3
12	malaria	10.1
13	gastrointestinal ulceration, recurrent, with dysfunctional platelets	10.1
14	sleeping sickness	10.1
15	strongyloidiasis	10.1
16	plasmodium falciparum malaria	10.1
17	hypogonadism	10.1
18	necatoriasis	10.1
19	exophthalmos	10.1
20	hydrocele	10.1
21	heterophyiasis	10.0	GPT ALB
22	afferent loop syndrome	10.0	GPT ALB
23	ankylosing spondylitis 1	10.0	GPT ALB
24	acalculous cholecystitis	10.0	GPT ALB
25	cholecystitis	10.0	GPT ALB
26	hepatic infarction	10.0	GPT ALB
27	hydrops of gallbladder	10.0	GPT ALB
28	splenic abscess	10.0	GPT ALB
29	critical illness polyneuropathy	10.0	GPT ALB
30	ascending cholangitis	10.0	GPT ALB
31	cholangitis	10.0	GPT ALB
32	gastrointestinal tuberculosis	10.0	GPT ALB
33	granulomatous hepatitis	10.0	GPT ALB
34	paralytic ileus	10.0	GPT ALB
35	acute cholangitis	10.0	GPT ALB
36	common bile duct disease	10.0	GPT ALB
37	bile duct disease	10.0	GPT ALB
38	coronary aneurysm	10.0	GPT ALB
39	hepatic coma	10.0	GPT ALB
40	abdominal tuberculosis	10.0	GPT ALB
41	bile duct cysts	10.0	GPT ALB
42	heart aneurysm	10.0	GPT ALB
43	splenic infarction	10.0	GPT ALB
44	pyuria	10.0	GPT ALB
45	pleural empyema	10.0	GPT ALB
46	kwashiorkor	10.0	GPT ALB
47	dicrocoeliasis	10.0	GPT ALB
48	klatskin's tumor	10.0	GPT ALB
49	hemorrhoid	10.0	GPT ALB
50	analbuminemia	10.0	GPT ALB

Graphical network of the top 20 diseases related to Dipetalonemiasis:

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Symptoms & Phenotypes for Dipetalonemiasis

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Drugs & Therapeutics for Dipetalonemiasis

Drugs for Dipetalonemiasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Doxycycline

Approved, Investigational, Vet_approved

Phase 2

564-25-0

54671203

Synonyms:

(2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(2Z,4S,4aR,5S,5aR,6R)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione

(4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

(4S,4AR,5S,5ar,6R,12as)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

10597-92-9

17086-28-1 (mono-hydrate)

24390-14-5

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)

41411-66-9 (6-epimer, mono-hydrochloride)

564-25-0

5-Hydroxy-a-6-deoxytetracycline

5-Hydroxy-alpha-6-deoxytetracycline

5-hydroxy-α-6-deoxytetracycline

5-Hydroxy-α-6-deoxytetracycline

69935-17-7 (mono-hydrochloride, di-hydrate)

6a-Deoxy-5-oxytetracycline

6alpha-deoxy-5-oxytetracycline

6-alpha-deoxy-5-oxytetracycline

6alpha-Deoxy-5-oxytetracycline

6-alpha-Deoxy-5-oxytetracycline

6-Deoxyoxytetracycline

6-Deoxytetracycline

6α-deoxy-5-oxytetracycline

6Α-deoxy-5-oxytetracycline

7164-70-7

7264-10-0

94088-85-4 (calcium salt (1:2))

AB08 (*Fosfatex)

AC1NQXW7

AC1NS4CW

AC1NUYS8

AC1O8PYM

alpha-6-Deoxy-5-hydroxytetracycline

alpha-6-Deoxyoxytetracycline

alpha-Doxycycline

Alti-Doxycycline

Anhydrous doxycycline

Apo-Doxy

Atridox

Azudoxat

BCBcMAP01_000024

BIDD:GT0146

BMY-28689

BPBio1_000951

BSPBio_000863

BSPBio_001936

BU-3839T

C06973

CHEBI:50845

CHEMBL1433

CID5281011

CID5353597

CID5463943

CID6713981

CPD001550033

D07876

DB00254

Deoxymykoin

DivK1c_000345

DMSC (*Fosfatex)

Dossiciclina

Dossiciclina [DCIT]

Doxcycline anhydrous

DOXCYCLINE ANHYDROUS

Doxiciclina

Doxiciclina [INN-Spanish]

Doxiciclina [Italian]

Doxitard

Doxivetin

DOXY

Doxy-Caps

Doxycen

Doxychel

Doxychel (TN)

Doxycin

Doxycyclin

doxycycline

Doxycycline

Doxycycline (200mg/day) or Placebo

Doxycycline (anhydrous)

Doxycycline (INN)

Doxycycline (internal use)

Doxycycline (TN)

Doxycycline anhydrous

DOXYCYCLINE CALCIUM

Doxycycline hyclate

Doxycycline monohydrate

DOXYCYCLINE MONOHYDRATE

Doxycycline-Chinoin

Doxycyclinum

Doxycyclinum [INN-Latin]

Doxy-Puren

Doxysol

Doxy-Tabs

Doxytec

Doxytetracycline

EINECS 209-271-1

GS-3065 (*monohydrate)

HMS2090E06

HSDB 3071

Hydramycin

IDI1_000345

Investin

Jenacyclin

KBio1_000345

KBio2_001287

KBio2_003855

KBio2_006423

KBio3_001156

KBioGR_001133

KBioSS_001287

Liviatin

Lopac0_000405

LS-187766

LS-93868

MolPort-002-507-423

Monodox

Monodox (*monohydrate)

NCGC00161602-01

NCGC00161602-03

NCGC00161602-04

NCGC00167961-01

NCGC00179395-01

NINDS_000345

Novo-Doxylin

NSC633557

Nu-Doxycycline

Oracea

Prestwick0_000852

Prestwick1_000852

Prestwick2_000852

Prestwick3_000852

Ronaxan

SAM002589932

SMP1_000107

Spanor

SPBio_000246

SPBio_002784

Spectrum_000807

Spectrum2_000143

Spectrum3_000408

Spectrum4_000527

Spectrum5_000947

STOCK1N-34341

Supracyclin

UNII-334895S862

UPCMLD-DP021

UPCMLD-DP021:001

Vibramycin

Vibramycin (*monohydrate)

Vibramycin Novum

Vibramycine

Vibra-tabs

Vibravenos

Vivox (*Hyclate)

2

Antimalarials

Phase 2

3

Antiprotozoal Agents

Phase 2

4

Anti-Bacterial Agents

Phase 2

5

Albendazole

Approved, Vet_approved

54965-21-8

2082

Synonyms:

((Propylthio)-5 1H-benzimidazolyl-2) carbamate de methyle

((Propylthio)-5 1H-benzimidazolyl-2) carbamate de methyle [French]

(5-(Propylthio)-1H-benzimidazol-2-yl)carbamate methyl ester

(5-(propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester

(5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester

(5-Propylsulfanyl-1H-benzoimidazol-2-yl)-carbamic acid methyl ester

[5-(Propylthio)benzimidazol-2-yl]carbamic Acid Methyl Ester

[5-(Propythio)-1H-benzimidazol-2-yl]carbamic acid methyl ester

5-(propylthio)-2-carbomethoxyaminobenzimidazole

5-(Propylthio)-2-carbomethoxyaminobenzimidazole

54965-21-8

A4673_FLUKA

A4673_SIGMA

AB00052377

AC-015

AC1L1CVL

AC1Q2YKD

AKOS000540882

Albendazol

Albendazol [INN-Spanish]

albendazole

Albendazole

Albendazole (JAN/USP/INN)

Albendazole [USAN:INN:BAN:JAN]

Albendazole armstrong brand

Albendazole Armstrong Brand

Albendazole diba brand

Albendazole Diba Brand

Albendazole fustery brand

Albendazole Fustery Brand

Albendazole hormona brand

Albendazole Hormona Brand

Albendazole liferpal brand

Albendazole Liferpal Brand

Albendazole monohydrochloride

Albendazole Monohydrochloride

Albendazole Noe-Socopharm Brand

Albendazole noé-socopharm brand

Albendazole pfizer brand

Albendazole Pfizer Brand

Albendazole sanicoopa brand

Albendazole Sanicoopa Brand

Albendazole valdecasas brand

Albendazole Valdecasas Brand

Albendazolum

Albendazolum [INN-Latin]

Albendoral

Albenza

Albenza (TN)

Albenza, Eskazole, Zentel, Andazol, Albendazole

Andazol

Armstrong brand OF albendazole

Armstrong Brand of Albendazole

BAS 00439961

BB_SC-1386

Bendapar

BIDD:GT0615

Bilutac

BIM-0051849.0001

BPBio1_000038

BRD-K79131256-001-04-7

BSPBio_000034

BSPBio_002548

C01779

CARBAMIC ACID, (5-(PROPYLTHIO)-1H-BENZIMIDAZOL-2-YL)-, METHYL ESTER

Carbamic acid, [5-(propylthio)-1H-benzimidazol-2-yl]-, methyl ester

CAS-54965-21-8

CHEBI:16664

CHEBI:506787

CHEMBL1483

ChemDiv1_000190

ChemDivAM_000003

CID2082

CPD000036735

D00134

D015766

DB00518

Diba brand OF albendazole

Diba Brand of Albendazole

Digezanol

Disthelm

Disthelm, mediamix V

Disthelm, Mediamix V

DivK1c_000704

EINECS 259-414-7

Endoplus

Eskazole

Fustery brand OF albendazole

Fustery Brand of Albendazole

Gascop

HMS1568B16

HMS1922K04

HMS2090G19

HMS2093K13

HMS502D06

HMS587I14

Hormona brand OF albendazole

Hormona Brand of Albendazole

HSDB 7444

I01-0380

IDI1_000704

InChI=1/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)

KBio1_000704

KBio2_002012

KBio2_004580

KBio2_007148

KBioGR_000801

KBioSS_002012

Liferpal brand OF albendazole

Liferpal Brand of Albendazole

LS-50618

Lurdex

Mediamix V disthelm

Mediamix V Disthelm

methyl [(2Z)-5-(propylsulfanyl)-1,3-dihydro-2H-benzimidazol-2-ylidene]carbamate

methyl [5-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate

methyl [5-(propylthio)-1H-benzimidazol-2-yl]carbamate

Methyl [5-(Propylthio)benzimidazol-2-yl]carbamate

methyl [6-(propylsulfanyl)-1H-benzimidazol-2-yl]carbamate

Methyl 5-(propylthio)-2-benzimidazolecarbamate

Methyl 5-(propyl-thio)-2-benzimidazolecarbamate

methyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate

methyl N-[6-(propylsulfanyl)-1H-1,3-benzodiazol-2-yl]carbamate

Methyl-5-[propylthio]-2-benzimidazole carbamate

Metiazol

MLS000069722

MolPort-000-726-929

MolPort-000-760-571

MolPort-001-932-918

Monohydrochloride, albendazole

Monohydrochloride, Albendazole

NCGC00016876-01

NCGC00016876-02

NCGC00022896-03

NCGC00022896-04

NCGC00022896-05

NCGC00022896-06

NCGC00022896-07

NINDS_000704

Noe Socopharm Brand of Albendazole

Noé socopharm brand OF albendazole

Noe-Socopharm Brand of Albendazole

Noé-socopharm brand OF albendazole

NSC 220008

NSC220008

O-methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate

O-Methyl N-(5-(propylthio)-2-benzimidazolyl)carbamate

O-Methyl N-(5-(propylthio)-2-benzimidazolyl)carbamic acid

Oprea1_429292

Oprea1_585016

Oprea1_640007

Pfizer brand OF albendazole

Pfizer Brand of Albendazole

Prestwick_675

Prestwick0_000247

Prestwick1_000247

Prestwick2_000247

Prestwick3_000247

Proftril

S1640_Selleck

SAM002589939

Sanicoopa brand OF albendazole

Sanicoopa Brand of Albendazole

SK And F 62979

SK And F62979

SK And F-62979

SK&F 62979

SK&F62979

SK&F-62979

SKF 62979

SKF62979

SKF-62979

Smith Kline & French Brand of Albendazole

SmithKline beecham brand OF albendazole

SmithKline Beecham Brand of Albendazole

SMR000036735

SPBio_002253

Spectrum_001532

SPECTRUM1503903

Spectrum4_000201

Spectrum5_001567

STK387550

STL046130

STOCK2S-67946

TL8003543

UNII-F4216019LN

V Disthelm, mediamix

V Disthelm, Mediamix

Valbazen

Valdecasas brand OF albendazole

Valdecasas Brand of Albendazole

VU0239747-6

Zental

Zentel

ZINC17146904

6

Ivermectin

Approved, Investigational, Vet_approved

70288-86-7

6474909

Synonyms:

(2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside

71827-03-7

AB00513813

AC1MJ4GR

AC1N7O27

BPBio1_000322

BRD-K24652731-001-02-7

BSPBio_000292

CHEMBL341047

CID11957587

CID4330618

CID6321424

CID6419971

CID6427057

EU-0100693

FT-0082656

HMS1568O14

HMS2089M09

I 8898

I8898_SIGMA

Ivermectin

IVERMECTIN

Ivermectina

Ivermectine

Ivermectinum

Lopac0_000693

MK-933

MLS001333247

MLS001333248

MLS002153248

MolPort-006-394-715

NCGC00094047-01

NCGC00094047-02

NCGC00094047-03

Prestwick_516

Prestwick2_000156

Prestwick3_000156

S1351_Selleck

SMR000857211

7

BCG vaccine

Approved, Investigational

8

Tubulin Modulators

9

Antimitotic Agents

10

Vaccines

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in Subjects With Schistosomiasis: A Pilot Study	Withdrawn	NCT02734186	Phase 4	Praziquantel
2	Treatment of Mansonella Perstans Infection in an Area Coendemic for Lymphatic Filariasis: A Pilot Study of the Effects of Doxycycline	Completed	NCT00340691	Phase 2	Doxycycline
3	Comparison of Early and Late Administration of Doxycycline in Their Efficacy Against Mansonella Perstans and in Development of Immunity Against Mycobacterial Infections	Completed	NCT02281643	Phase 2	Doxycycline
4	Studies on the Epidemiology and Control of Mansonella Perstans Infection in Uganda	Completed	NCT00215280		ivermectin and albendazole
5	Mansonella Perstans Effects on BCG Vaccine-induced Protection Against Childhood Tuberculosis (TB) as Well as TB Disease Severity and Recovery in Cameroon (MAP-TB)	Recruiting	NCT04547738		TB treatment according to national guidelines

Search NIH Clinical Center for Dipetalonemiasis

Cochrane evidence based reviews: dipetalonema infections

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Genetic Tests for Dipetalonemiasis

Sources

Anatomical Context for Dipetalonemiasis

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Publications for Dipetalonemiasis

Articles related to Dipetalonemiasis:

#	Title	Authors	PMID	Year
1	Specific serodiagnosis with adult Onchocerca volvulus antigen in an enzyme-linked immunosorbent assay. ⁶¹	Tada I...Nwoke BE	3469920	1987
2	Clinical responses of dogs to experimentally induced Dipetalonema reconditum infection. ⁶¹	Lindemann BA...McCall JW	6685983	1983
3	[An epidemiological study of human filariasis : loaiasis, dipetalonemiasis, tetrapetalonemiasis, in Douala fisherman of the river Wouri estuary (Cameroon) (author's transl)]. ⁶¹	Ripert C...Same Ekobo A	6936744	1980
4	[Dipetalonemiasis--clinical picture and treatment (review of the literature)]. ⁶¹	Zal'nova NS...Omel'chenko OG	564444	1977

Sources

Genes for Dipetalonemiasis

Genes related to Dipetalonemiasis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	4.72	DISEASES inferred ¹⁵
2	MT-CO1	Mitochondrially Encoded Cytochrome C Oxidase I	Protein Coding	4.5	DISEASES inferred ¹⁵
3	ALB	Albumin	Protein Coding	4.1	DISEASES inferred ¹⁵

Sources

Variations for Dipetalonemiasis

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Expression for Dipetalonemiasis

Search GEO for disease gene expression data for Dipetalonemiasis.

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Pathways for Dipetalonemiasis

Sources

GO Terms for Dipetalonemiasis

Molecular functions related to Dipetalonemiasis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	pyridoxal phosphate binding	GO:0030170	8.62	GPT ALB

Sources

Sources for Dipetalonemiasis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia