MCID: DPH012
MIFTS: 25

Diphallia

Categories: Rare diseases, Fetal diseases

Aliases & Classifications for Diphallia

MalaCards integrated aliases for Diphallia:

Name: Diphallia 53 59
Diphallus 53

Characteristics:

Orphanet epidemiological data:

59
diphallia
Age of onset: Infancy,Neonatal; Age of death: normal life expectancy;

Classifications:



Summaries for Diphallia

MalaCards based summary : Diphallia, also known as diphallus, is related to diphallus rachischisis imperforate anus and hypospadias. Affiliated tissues include kidney, colon and heart, and related phenotypes are bifid scrotum and bifid penis

Wikipedia : 76 Diphallia, penile duplication (PD), diphallic terata, or diphallasparatus, is a rare developmental... more...

Related Diseases for Diphallia

Diseases related to Diphallia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 diphallus rachischisis imperforate anus 11.9
2 hypospadias 9.9
3 anus, imperforate 9.9
4 urethritis 9.9
5 urethral stricture 9.9

Graphical network of the top 20 diseases related to Diphallia:



Diseases related to Diphallia

Symptoms & Phenotypes for Diphallia

Human phenotypes related to Diphallia:

59 32 (show all 29)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 bifid scrotum 59 32 hallmark (90%) Very frequent (99-80%) HP:0000048
2 bifid penis 59 32 hallmark (90%) Very frequent (99-80%) HP:0100599
3 hypospadias 59 32 frequent (33%) Frequent (79-30%) HP:0000047
4 anal atresia 59 32 frequent (33%) Frequent (79-30%) HP:0002023
5 distal urethral duplication 59 32 frequent (33%) Frequent (79-30%) HP:0008706
6 ectopic scrotum 59 32 frequent (33%) Frequent (79-30%) HP:0030275
7 penoscrotal transposition 59 32 frequent (33%) Frequent (79-30%) HP:0100600
8 inguinal hernia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000023
9 cryptorchidism 59 32 occasional (7.5%) Occasional (29-5%) HP:0000028
10 epispadias 59 32 occasional (7.5%) Occasional (29-5%) HP:0000039
11 ureteral duplication 59 32 occasional (7.5%) Occasional (29-5%) HP:0000073
12 renal duplication 59 32 occasional (7.5%) Occasional (29-5%) HP:0000075
13 horseshoe kidney 59 32 occasional (7.5%) Occasional (29-5%) HP:0000085
14 atrial septal defect 59 32 occasional (7.5%) Occasional (29-5%) HP:0001631
15 bladder exstrophy 59 32 occasional (7.5%) Occasional (29-5%) HP:0002836
16 abnormality of the pubic bone 59 32 occasional (7.5%) Occasional (29-5%) HP:0003172
17 renal malrotation 59 32 occasional (7.5%) Occasional (29-5%) HP:0004712
18 abnormal spermatogenesis 59 32 occasional (7.5%) Occasional (29-5%) HP:0008669
19 cloacal exstrophy 59 32 occasional (7.5%) Occasional (29-5%) HP:0010475
20 scoliosis 59 32 very rare (1%) Very rare (<4-1%) HP:0002650
21 hemivertebrae 59 32 very rare (1%) Very rare (<4-1%) HP:0002937
22 butterfly vertebrae 59 32 very rare (1%) Very rare (<4-1%) HP:0003316
23 rectoperineal fistula 59 32 very rare (1%) Very rare (<4-1%) HP:0004792
24 duplicated colon 59 32 very rare (1%) Very rare (<4-1%) HP:0005223
25 absent thumb 59 32 very rare (1%) Very rare (<4-1%) HP:0009777
26 abnormality of the genitourinary system 59 Very frequent (99-80%)
27 abnormal heart morphology 59 Occasional (29-5%)
28 abnormality of the gastrointestinal tract 59 Occasional (29-5%)
29 gastrointestinal duplication 59 Occasional (29-5%)

Drugs & Therapeutics for Diphallia

Search Clinical Trials , NIH Clinical Center for Diphallia

Genetic Tests for Diphallia

Anatomical Context for Diphallia

MalaCards organs/tissues related to Diphallia:

41
Kidney, Colon, Heart, Bone

Publications for Diphallia

Articles related to Diphallia:

(show all 30)
# Title Authors Year
1
Diphallia in a Mixed-Breed Puppy: Case Report. ( 28792795 )
2017
2
Diphallia in the Ancient World: Insights From a Pompeian Fresco (70-79 AD). ( 27562204 )
2016
3
Unusual Variant of Coronal Bladder Duplication Associated with Glans Diphallia: A Case Report and Review of the Literature. ( 26114007 )
2015
4
Prenatal diagnosis of true diphallia and associated anomalies. ( 25004320 )
2014
5
A rare case of isolated complete diphallia and review of the literature. ( 23413289 )
2013
6
Diphallia with associated anomalies: a case report and literature review. ( 24383036 )
2013
7
Isolated diphallia: case report and literature review. ( 19431105 )
2009
8
A case of perineal lipoma with accessory scrotum and pseudo- diphallia. ( 19221954 )
2009
9
Complete diphallia. ( 19230173 )
2008
10
MRI in the diagnosis of diphallia. ( 17909781 )
2007
11
Complete diphallia, imperforate ani (type 2 atresia ani), and an accessory scrotum in a 5-day-old calf. ( 16921886 )
2006
12
Successful surgical correction of true diphallia, scrotal duplication, and associated hypospadias. ( 17011251 )
2006
13
Complete diphallia. ( 15764263 )
2004
14
Complete diphallia associated with features of covered exstrophy. ( 11431797 )
2001
15
Diphallia and the VATER association. ( 10569606 )
1999
16
Complete lower urinary tract duplication with true diphallia presenting as a rare covered exstrophy variant. ( 9112561 )
1997
17
True complete diphallia. ( 7569806 )
1995
18
Diphallia and hindgut duplication. ( 1989030 )
1991
19
Diphallia in a mixed-breed dog with multiple anomalies. ( 16726645 )
1989
20
Value of sonography in true complete diphallia. ( 2664222 )
1989
21
Diphallia associated with malformation of hindgut derivatives. ( 2919482 )
1989
22
A case of diphallia. ( 3727229 )
1986
23
Diphallia with a normal and a blind-ending urethra. ( 446509 )
1979
24
Diphallia. ( 4772820 )
1973
25
Diphallia: report of a case. ( 5047441 )
1972
26
Diphallia in a Holstein bull. ( 5101822 )
1971
27
Diphallia. Report of a case. ( 5471752 )
1970
28
Diphallia: report of a case. ( 5846196 )
1965
29
TOTAL DIPHALLIA: A CASE OF PLASTIC REPAIR. ( 14104422 )
1964
30
Ectopic scrotum and diphallia: report of a case. ( 13791708 )
1960

Variations for Diphallia

Expression for Diphallia

Search GEO for disease gene expression data for Diphallia.

Pathways for Diphallia

GO Terms for Diphallia

Sources for Diphallia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
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40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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