MCID: DRF001
MIFTS: 41

Dirofilariasis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Dirofilariasis

MalaCards integrated aliases for Dirofilariasis:

Name: Dirofilariasis 12 53 59 3 44 15 73
Dirofilaria Infectious Disease 12
Infection by Dirofilaria 12

Characteristics:

Orphanet epidemiological data:

59
dirofilariasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1082
ICD10 33 B74.8
MeSH 44 D004184
SNOMED-CT 68 73328005
Orphanet 59 ORPHA166291
MESH via Orphanet 45 D004184
UMLS via Orphanet 74 C0012602
ICD10 via Orphanet 34 B74.8
UMLS 73 C0012602

Summaries for Dirofilariasis

NIH Rare Diseases : 53 Dirofilariasis refers to infections caused by Dirofilaria roundworms. Although the natural hosts of these roundworms are dogs, wild canids (such as wolves and foxes) and raccoons, humans can be infected with Dirofilaria larvae through mosquito bites. Signs and symptoms of dirofilariasis generally include nodules under the skin or lung granulomas (small nodules formed by an inflammatory reaction) which may be asymptomatic. Some people with dirofilariasis of the lungs may also experience cough, chest pain, fever, wheezing, chills, and pleural effusion (excess fluid between the tissues that line the lungs and the chest cavity). Dirofilariasis is treated with surgical removal of lung granulomas and skin nodules.

MalaCards based summary : Dirofilariasis, also known as dirofilaria infectious disease, is related to epididymitis and louping ill. An important gene associated with Dirofilariasis is UBASH3A (Ubiquitin Associated And SH3 Domain Containing A), and among its related pathways/superpathways are A-beta Pathways: Plaque Formation and APP Metabolism and amb2 Integrin signaling. Affiliated tissues include lung, skin and breast, and related phenotypes are cardiovascular system and cellular

Disease Ontology : 12 A filariasis that is a zoonotic infection caused by nematodes Dirofilaria immitis or Dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. The disease manifests as either subcutaneous nodules or pulmonary lesions.

Wikipedia : 76 Dirofilariasis is an infection by parasites of the genus... more...

Related Diseases for Dirofilariasis

Diseases related to Dirofilariasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 epididymitis 29.5 CD40LG CRP
2 louping ill 10.8 CD40LG STAB2
3 cryofibrinogenemia 10.8 CD40LG HP
4 sparganosis 10.8 CTSL MT-CO1
5 west nile fever 10.8 CD40LG STAB2
6 geniculate herpes zoster 10.7 CD40LG HP
7 fiedler's myocarditis 10.7 CTSL CUX1
8 fasciolopsiasis 10.7 CD40LG CTSL
9 cerebral arteritis 10.6 CD40LG PLG
10 neuronitis 10.6 CD40LG MB
11 glandular tularemia 10.6 CRP STAB2
12 parasitic protozoa infectious disease 10.6 CD40LG HP MT-CO1
13 evans' syndrome 10.5 CD40LG HP
14 murray valley encephalitis 10.5 CD40LG STAB2
15 taeniasis 10.5 CD40LG CTSL MT-CO1
16 acquired angioedema 10.5 CRP HP
17 parasitic helminthiasis infectious disease 10.5 CD40LG CTSL MT-CO1
18 chronic meningitis 10.5 CRP MT-CO1
19 ulceroglandular tularemia 10.5 CRP STAB2
20 acalculous cholecystitis 10.4 CD40LG CRP
21 mononeuritis multiplex 10.4 CD40LG CRP
22 erysipeloid 10.4 GAPDH PLG UBASH3A
23 intracranial vasospasm 10.4 HP PLAT
24 sleeping sickness 10.4 AMD1 GAPDH HP
25 melancholia 10.3 CRP HP
26 acute maxillary sinusitis 10.3 CD40LG CRP
27 middle cerebral artery infarction 10.3 CD40LG PLAT
28 blue toe syndrome 10.3 CRP PLG
29 japanese spotted fever 10.3 CD40LG CRP
30 ligneous conjunctivitis 10.3 PLAT PLG
31 danubian endemic familial nephropathy 10.2 CD40LG UBASH3A
32 inferior myocardial infarction 10.2 PLAT PLG
33 central retinal artery occlusion 10.2 PLAT PLG
34 takayasu arteritis 10.1 CD40LG CRP PON1
35 intracranial embolism 10.1 PLAT PLG
36 suppurative otitis media 10.1 CD40LG CRP
37 myocarditis 10.0 CD40LG MB TNNI3
38 cardiogenic shock 10.0 CRP PLAT
39 coronary stenosis 10.0 CRP PON1 TNNI3
40 deficiency anemia 10.0 CRP HP PON1
41 lung cancer 10.0
42 pulmonary coin lesion 10.0
43 langerhans cell histiocytosis 9.9
44 hepatitis 9.9
45 filariasis 9.9
46 histiocytosis 9.9
47 meningitis 9.9
48 rheumatic myocarditis 9.9 CRP TNNI3
49 dressler's syndrome 9.8 CD40LG CRP PLAT
50 cardiac rupture 9.8 CRP PLAT

Graphical network of the top 20 diseases related to Dirofilariasis:



Diseases related to Dirofilariasis

Symptoms & Phenotypes for Dirofilariasis

MGI Mouse Phenotypes related to Dirofilariasis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.07 PLG PON1 RET STAB2 TKT TNNI3
2 cellular MP:0005384 9.85 TPT1 CD40LG HP MB MT-CO1 NSUN2
3 muscle MP:0005369 9.5 MB MT-CO1 NSUN2 PLAT RET STAB2
4 respiratory system MP:0005388 9.17 MB NSUN2 PLAT PLG RET STAB2

Drugs & Therapeutics for Dirofilariasis

Search Clinical Trials , NIH Clinical Center for Dirofilariasis

Cochrane evidence based reviews: dirofilariasis

Genetic Tests for Dirofilariasis

Anatomical Context for Dirofilariasis

MalaCards organs/tissues related to Dirofilariasis:

41
Lung, Skin, Breast, Testes, B Cells, Heart, Eye

Publications for Dirofilariasis

Articles related to Dirofilariasis:

(show top 50) (show all 418)
# Title Authors Year
1
A rare case of human pulmonary dirofilariasis with nodules mimicking malignancy: approach to diagnosis and treatment. ( 29891007 )
2018
2
Conjunctival Dirofilariasis Causing Symptoms for 1 Day. ( 29351119 )
2018
3
Dirofilariasis mimicking an osteoma. ( 29323001 )
2018
4
The Canary Islands as a model of risk of pulmonary dirofilariasis in a hyperendemic area. ( 29396676 )
2018
5
Ocular dirofilariasis: Ophthalmic implication of climate change on vector-borne parasites. ( 29260070 )
2017
6
Subcutaneous dirofilariasis caused by Dirofilaria (Nochtiella) repens in Sri Lanka: A potential risk of transmitting human dirofilariasis. ( 28491315 )
2017
7
Human Subconjunctival Dirofilariasis Presenting as the Daytime Photophobia: A Case Report. ( 29308388 )
2017
8
An unusual presentation of lacrimal gland dirofilariasis. ( 28724822 )
2017
9
Ocular Dirofilariasis: A Rare case from Mumbai, India. ( 28764165 )
2017
10
Ocular dirofilariasis by Dirofilaria immitis in a child in Iran: A case report and review of the literature. ( 27815230 )
2017
11
Dirofilariasis in a Female Adult Patient in Israel. ( 28971644 )
2017
12
Clinical and laboratory features of human dirofilariasis in Russia. ( 28791217 )
2017
13
Delayed diagnosis of subcutaneous dirofilariasis following a mosquito bite sustained in Germany. ( 28557282 )
2017
14
Intradural Dirofilariasis in a Dog with Chronic Cervical Pain. ( 27841685 )
2017
15
A case of orbital dirofilariasis in New York. ( 28812912 )
2017
16
A case of human ocular dirofilariasis in a patient with multiple endocrine neoplasia in Northwest Spain. ( 29223316 )
2017
17
Dirofilariasis Presenting as an Infiltrative Mass in the Right Buccal Space. ( 27305941 )
2016
18
Periocular dirofilariasis: A case series. ( 26819190 )
2016
19
Rare case of epididymal dirofilariasis. ( 26976948 )
2016
20
Human pulmonary dirofilariasis masquerading as a mass. ( 27432058 )
2016
21
Subcutaneous Dirofilariasis: A Masquerade of a Palisaded Granulomatous Dermatitis. ( 28000235 )
2016
22
Periorbital Dirofilariasis: A Rare Case from Western India. ( 27134918 )
2016
23
Human dirofilariasis in the eyelid caused by Dirofilaria repens: An imported case. ( 27544021 )
2016
24
Subcutaneous and Pulmonary Dirofilariasis with Evidence of Splenic Involvement. ( 27579206 )
2016
25
A rare case of human pulmonary dirofilariasis with a growing pulmonary nodule after migrating infiltration shadows, mimicking primary lung carcinoma. ( 27015012 )
2016
26
Subcutaneous filariasis in India- Possible indication of human Dirofilariasis. ( 27004586 )
2016
27
Human Ocular Dirofilariasis in Hong Kong. ( 26636400 )
2016
28
Ocular dirofilariasis: Series of three cases and review of literature. ( 27080800 )
2016
29
Human subcutaneous dirofilariasis of forearm an unusual presentation. ( 25657423 )
2015
30
Dirofilariasis - an emergent human parasitosis in Romania. ( 26204187 )
2015
31
Dirofilariasis by Dirofilaria repens: an imported case and a brief review. ( 25769814 )
2015
32
Pulmonary dirofilariasis: A diagnostic pitfall in clinical practice. ( 26526293 )
2015
33
Human ocular dirofilariasis due to Dirofilaria repens in Sri Lanka. ( 26706673 )
2015
34
Dirofilariasis involving the oral cavity: report of the first case from South America. ( 26108021 )
2015
35
Human subcutaneous dirofilariasis caused by Dirofilaria immitis in a Greek adult. ( 26166816 )
2015
36
Human subcutaneous/ocular dirofilariasis in the Russian Federation and Belarus, 1997-2013. ( 25722281 )
2015
37
A rare case of anterior chamber dirofilariasis. ( 25709276 )
2015
38
Human dirofilariasis: an emerging zoonosis in India. ( 26064035 )
2015
39
Dirofilariasis Mimicking an Acute Scrotum. ( 25626639 )
2015
40
Subcutaneous Infraorbital Dirofilariasis. ( 26288429 )
2015
41
Oral dirofilariasis. ( 26470974 )
2015
42
Subconjunctival dirofilariasis caused by Dirofilaria repens: A case report with short review. ( 26275256 )
2015
43
Human dirofilariasis: A fast emerging zoonosis in India. ( 26470975 )
2015
44
Subcutaneous dirofilariasis of the eyelid in a 7-month-old infant. ( 25871532 )
2015
45
HUMAN SUBCUTANEOUS DIROFILARIASIS - CASE REPORT. ( 26591641 )
2015
46
Subcutaneous human Dirofilariasis in Vidarbha. ( 26275274 )
2015
47
Subcutaneous human dirofilariasis. ( 25566903 )
2015
48
First detection of human dirofilariasis in South Africa. ( 25874068 )
2015
49
Risk factors for human heartworm infections (dirofilariasis) in the South. ( 25978057 )
2015
50
Cutaneous and pulmonary dirofilariasis due to Dirofilaria repens. ( 25918821 )
2015

Variations for Dirofilariasis

Expression for Dirofilariasis

Search GEO for disease gene expression data for Dirofilariasis.

Pathways for Dirofilariasis

Pathways related to Dirofilariasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.62 PLAT PLG
2 10.48 HP PLAT PLG
3 10.27 PLAT PLG
4 9.86 MB MT-CO1

GO Terms for Dirofilariasis

Cellular components related to Dirofilariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 CD40LG CRP CTSL HP PLAT PLG
2 extracellular exosome GO:0070062 9.36 CRP CTSL GAPDH HP MB PLAT

Biological processes related to Dirofilariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibrinolysis GO:0042730 8.62 PLAT PLG

Molecular functions related to Dirofilariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.55 CRP PON1 RET STAB2 TPT1
2 low-density lipoprotein particle binding GO:0030169 8.96 CRP STAB2
3 serine-type endopeptidase activity GO:0004252 8.92 CTSL HP PLAT PLG

Sources for Dirofilariasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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