MCID: DRF001
MIFTS: 32

Dirofilariasis

Categories: Infectious diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Dirofilariasis

MalaCards integrated aliases for Dirofilariasis:

Name: Dirofilariasis 12 20 58 3 44 15 17 70
Dirofilaria Infectious Disease 12
Infection by Dirofilaria 12

Characteristics:

Orphanet epidemiological data:

58
dirofilariasis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:1082
MeSH 44 D004184
SNOMED-CT 67 73328005
ICD10 32 B74.8
MESH via Orphanet 45 D004184
ICD10 via Orphanet 33 B74.8
UMLS via Orphanet 71 C0012602
Orphanet 58 ORPHA166291
UMLS 70 C0012602

Summaries for Dirofilariasis

GARD : 20 Dirofilariasis refers to infections caused by Dirofilaria roundworms. Although the natural hosts of these roundworms are dogs, wild canids (such as wolves and foxes) and raccoons, humans can be infected with Dirofilaria larvae through mosquito bites. Signs and symptoms of dirofilariasis generally include nodules under the skin or lung granulomas (small nodules formed by an inflammatory reaction) which may be asymptomatic. Some people with dirofilariasis of the lungs may also experience cough, chest pain, fever, wheezing, chills, and pleural effusion (excess fluid between the tissues that line the lungs and the chest cavity). Dirofilariasis is treated with surgical removal of lung granulomas and skin nodules.

MalaCards based summary : Dirofilariasis, also known as dirofilaria infectious disease, is related to vascular disease and filariasis. An important gene associated with Dirofilariasis is MT-CO1 (Mitochondrially Encoded Cytochrome C Oxidase I), and among its related pathways/superpathways is Cardiac muscle contraction. Affiliated tissues include lung, breast and eye.

Disease Ontology : 12 A filariasis that is a zoonotic infection caused by nematodes Dirofilaria immitis or Dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. The disease manifests as either subcutaneous nodules or pulmonary lesions.

CDC : 3 Dirofilaria are long, thin parasitic roundworms that infect a variety of mammals. Infection is transmitted by mosquito bites. There are many species of Dirofilaria, but human infection is caused most commonly by three species, D. immitis, D. repens, and D. tenuis. The main natural hosts for these three species are dogs and wild canids, such as foxes and wolves (D. immitis and D. repens) and raccoons (D. tenuis). D. immitis is also known as "heartworm." D. repens is not found in the United States, and D. tenuis appears to be restricted to raccoons in North America.

Wikipedia : 73 Dirofilariasis is an infection by parasites of the genus Dirofilaria. It is transmitted through a... more...

Related Diseases for Dirofilariasis

Diseases related to Dirofilariasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 vascular disease 29.1 PTGS1 PON1 HP
2 filariasis 10.4
3 hypereosinophilic syndrome 10.4
4 pulmonary coin lesion 10.3
5 parasitic helminthiasis infectious disease 10.2
6 virus-associated trichodysplasia spinulosa 10.2
7 thelaziasis 10.2 PTGS1 MT-CO1
8 cellulitis 10.2
9 baylisascariasis 10.2 PTGS1 MT-CO1
10 posttransplant acute limbic encephalitis 10.1
11 scleritis 10.0
12 conjunctivitis 10.0
13 toxocariasis 10.0
14 babesiosis 10.0 MT-CO1 HP
15 aortic valve insufficiency 9.9 TNNI3 PON1
16 coronary stenosis 9.9 TNNI3 PON1
17 volvulus of midgut 9.9
18 langerhans cell histiocytosis 9.9
19 orbital cellulitis 9.9
20 onchocerciasis 9.9
21 lymphadenitis 9.9
22 histiocytosis 9.9
23 congestive heart failure 9.9
24 exophthalmos 9.9
25 parasitic protozoa infectious disease 9.9 MT-CO1 HP
26 chronic urticaria 9.9 TPT1 PTGS1
27 pulmonary edema 9.8 TNNI3 HP
28 intracranial berry aneurysm 9.8 TNNI3 HP
29 lipomatosis, multiple 9.8
30 sarcoidosis 1 9.8
31 temporal arteritis 9.8
32 testicular torsion 9.8
33 myasthenia gravis 9.8
34 osteogenic sarcoma 9.8
35 thymoma, familial 9.8
36 yemenite deaf-blind hypopigmentation syndrome 9.8
37 malaria 9.8
38 proteinuria, chronic benign 9.8
39 ifap syndrome 2 9.8
40 pulmonary hypertension 9.8
41 ptosis 9.8
42 benign teratoma 9.8
43 pleomorphic lipoma 9.8
44 pleurisy 9.8
45 eosinophilic meningitis 9.8
46 interstitial nephritis 9.8
47 strongyloidiasis 9.8
48 allergic conjunctivitis 9.8
49 erysipelas 9.8
50 allergic disease 9.8

Graphical network of the top 20 diseases related to Dirofilariasis:



Diseases related to Dirofilariasis

Symptoms & Phenotypes for Dirofilariasis

Drugs & Therapeutics for Dirofilariasis

Search Clinical Trials , NIH Clinical Center for Dirofilariasis

Cochrane evidence based reviews: dirofilariasis

Genetic Tests for Dirofilariasis

Anatomical Context for Dirofilariasis

MalaCards organs/tissues related to Dirofilariasis:

40
Lung, Breast, Eye, Bone Marrow, Lymph Node, Kidney, Heart

Publications for Dirofilariasis

Articles related to Dirofilariasis:

(show top 50) (show all 916)
# Title Authors PMID Year
1
Molecular Analysis of Dirofilaria repens Isolates from Eye-Care Patients in Greece. 61
32780297 2021
2
The first case of periorbital human dirofilariasis in the Czech Republic. 61
33415394 2021
3
The first case of autochthonous subcutaneous dirofilariasis (Dirofilaria repens) in a dog from Białowieża (NE Poland) and possible threat posed to inhabitants of Białowieża Primeval Forest area. 61
33205237 2021
4
Severe Concomitant Physaloptera sp., Dirofilaria immitis, Toxocara cati, Dipylidium caninum, Ancylostoma sp. and Taenia taeniaeformis Infection in a Cat. 61
33499121 2021
5
Emerging risk of Dirofilaria spp. infection in Northeastern Europe: high prevalence of Dirofilaria repens in sled dog kennels from the Baltic countries. 61
33441797 2021
6
Description of the rare localization of Dirofilaria repens in human in the right inguinal lymph node. 61
33304811 2021
7
Developmental regulation of Dirofilaria immitis microfilariae and evaluation of ecdysone signaling pathway transcript level using droplet digital PCR. 61
33298156 2020
8
Human ocular dirofilariasis masquerading as a malignancy. 61
33092871 2020
9
[Inguinal lymphadenitis due to invasion of Dirofilaria repens]. 61
33720606 2020
10
The trends of human dirofilariasis in Croatia: Yesterday - Today - Tomorrow. 61
33117870 2020
11
Conjunctival dirofilariasis presenting as a painless, cystic nodule: An unusual manifestation. 61
33120668 2020
12
Molecular detection of Dirofilaria spp. and host blood-meal identification in the Simulium turgaicum complex (Diptera: Simuliidae) in the Aras River Basin, northwestern Iran. 61
33148310 2020
13
Dirofilariasis presenting as scleritis: A report of two cases. 61
32823440 2020
14
Clinical presentation, cardiovascular findings, etiology, and outcome of myocarditis in dogs: 64 cases with presumptive antemortem diagnosis (26 confirmed postmortem) and 137 cases with postmortem diagnosis only (2004-2017). 61
32668360 2020
15
The global status of Dirofilaria immitis in dogs: a systematic review and meta-analysis based on published articles. 61
32330696 2020
16
Identification and validation of a commercial cryopreservation medium for the practical preservation of Dirofilaria immitis microfilaria. 61
32727546 2020
17
Clinical and diagnostic imaging findings in 37 rescued dogs with heartworm disease in Germany. 61
32526608 2020
18
Ocular Dirofilariasis in Bosnia and Herzegovina: A Case Report and Review of the Literature. 61
32775807 2020
19
Molecular characterization of ocular dirofilariasis: a case report of Dirofilaria immitis in south-eastern Iran. 61
32677898 2020
20
Pseudo-Tumor of the Epididymis, a Rare Clinical Presentation of Human Dirofilaria repens Infection: a Report of Autochthonous Case of Dirofilariasis in Southwestern Slovakia. 61
31960220 2020
21
Pictorial Review of Thoracic Parasitic Diseases: A Radiologic Guide. 61
31978430 2020
22
A case of human Dirofilaria repens infection, causing an asymptomatic subcutaneous nodule. 61
32206885 2020
23
Synopsis of the mosquitoes (Diptera: Culicidae) of Romania. 61
33055623 2020
24
Case Report: Successful Treatment of a Patient with Microfilaremic Dirofilariasis Using Doxycycline. 61
32043447 2020
25
First European cases of oral repens dirofilariasis. 61
31926347 2020
26
Anthology of Dirofilariasis in Russia (1915-2017). 61
32283873 2020
27
Rat volatiles as an attractant source for the Asian tiger mosquito, Aedes albopictus. 61
32198359 2020
28
Extensive Chorio-retinal Damage Due to Dirofilaria Repens- Report of a Case. 61
32159417 2020
29
Pig-hunting dogs are an at-risk population for canine heartworm (Dirofilaria immitis) infection in eastern Australia. 61
32054524 2020
30
A cross sectional study on Dirofilaria immitis and Acanthocheilonema reconditum in sheepdogs in a western region in Iran. 61
32782749 2020
31
Morphological Description, Phylogenetic and Molecular Analysis of Dirofilaria immitis Isolated from Dogs in the Northwest of Iran. 61
32489376 2020
32
[Features of granulomatous inflammation in helminthiasis, mycoses and human protozoal diseases in forensic medical practice]. 61
33180415 2020
33
Several Cases of Ocular Dirofilariasis in Bulgaria. 61
32460293 2020
34
Seroepidemiological Study of Canine and Human Dirofilariasis in the Endemic Region of Northern Serbia. 61
33134332 2020
35
Tender migratory nodules on lower limb - A case report of human subcutaneous dirofilariasis. 61
32031156 2020
36
Ocular Dirofilariasis after Clinically Manifested Subcutaneous Migration of the Parasite: A Case Report. 61
32489388 2020
37
Oral migration of Dirofilaria repens after creeping dermatitis. 61
32186510 2020
38
Dirofilaria hongkongensis - A first report of potential zoonotic dirofilariosis infection in dogs from Tamil Nadu. 61
31796197 2019
39
Human case of subcutaneous nodule because of a novel genetic variation of Dirofilaria sp. 61
31389046 2019
40
[MULTI-FACTOR MODEL OF FINANCING PREVENTION AND TREATMENT OF DIROPHILARIOSIS (BASIC PRINCIPLES AND INDICATORS OF EFFICIENCY)]. 61
31804221 2019
41
Dirofilariasis: a parasitic cause of subcutaneous nodule. 61
31229594 2019
42
Encapsulated living worms due to periorbital dirofilariasis: detection with high-resolution sonography. 61
30859409 2019
43
Thirteen cases of pulmonary dirofilariasis in a single institution in Okinawa Island. 61
31254069 2019
44
There is a worm in my eye! Ocular dirofilariasis. 61
30270664 2019
45
Rare cause of floaters: A motile live worm in vitreous cavity. 61
31436210 2019
46
Human Dirofilariasis in Bulgaria Between 2009 and 2018. 61
31662696 2019
47
Circulating and bone marrow myeloid cells containing Leishmania amastigotes in a case of advanced canine leishmaniosis. 61
31272298 2019
48
A possible relationship between Thromboxane B2 and Leukotriene B4 and the encapsulation of Dirofilaria repens worms in human subcutaneous dirofilariasis. 61
31339092 2019
49
Imaging Findings of Subcutaneous Human Dirofilariasis. 61
31378402 2019
50
Subconjunctival Dirofilariasis Presenting as Orbital Cellulitis. 61
31206462 2019

Variations for Dirofilariasis

Expression for Dirofilariasis

Search GEO for disease gene expression data for Dirofilariasis.

Pathways for Dirofilariasis

Pathways related to Dirofilariasis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.56 TNNI3 MT-CO1

GO Terms for Dirofilariasis

Biological processes related to Dirofilariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 8.62 PTGS1 HP

Sources for Dirofilariasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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