Aliases & Classifications for Discharging Ear

MalaCards integrated aliases for Discharging Ear:

Name: Discharging Ear 12 15

Classifications:



Summaries for Discharging Ear

MalaCards based summary : Discharging Ear is related to otitis media and suppurative otitis media. An important gene associated with Discharging Ear is MCF2 (MCF.2 Cell Line Derived Transforming Sequence), and among its related pathways/superpathways are Signaling by Rho GTPases and Cytoskeletal Signaling. The drugs Ciprofloxacin and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include lung.

Related Diseases for Discharging Ear

Diseases related to Discharging Ear via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 otitis media 9.7
2 suppurative otitis media 9.7

Symptoms & Phenotypes for Discharging Ear

Drugs & Therapeutics for Discharging Ear

Drugs for Discharging Ear (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 85721-33-1 2764
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
3
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
4 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
6 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
7 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
9 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
10 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1
11 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
12 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
14 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
15 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
16 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
17 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
18 Hormones Phase 4,Phase 3,Phase 2,Phase 1
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
20 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
22
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1
23 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
24 Antibiotics, Antitubercular Phase 4,Phase 3
25 Fluoroquinolones Phase 4,Phase 3,Phase 2
26 Antidotes Phase 4
27 Antioxidants Phase 4
28 Antiviral Agents Phase 4
29 Expectorants Phase 4
30 N-monoacetylcystine Phase 4
31 Protective Agents Phase 4
32 Respiratory System Agents Phase 4
33
Estradiol Approved, Investigational, Vet_approved Phase 3,Phase 2 50-28-2 5757
34 Estradiol valerate Approved, Investigational, Vet_approved Phase 3,Phase 2 979-32-8
35
Ethinyl Estradiol Approved Phase 3,Phase 2 57-63-6 5991
36
Moxifloxacin Approved, Investigational Phase 3,Phase 2 354812-41-2, 151096-09-2 152946
37
Norgestimate Approved, Investigational Phase 3,Phase 2 35189-28-7 6540478
38
Polyestradiol phosphate Approved Phase 3,Phase 2 28014-46-2
39
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
40
Ofloxacin Approved Phase 3 82419-36-1 4583
41
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
42
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
43
Dipivefrin Approved Phase 3,Phase 2 52365-63-6 3105
44
Butyric Acid Experimental, Investigational Phase 3 107-92-6 264
45 Contraceptive Agents Phase 3,Phase 2
46 Contraceptives, Oral Phase 3,Phase 2
47 Contraceptives, Oral, Combined Phase 3,Phase 2
48 Estradiol 17 beta-cypionate Phase 3,Phase 2
49 Estradiol 3-benzoate Phase 3,Phase 2
50 Norgestimate, ethinyl estradiol drug combination Phase 3,Phase 2

Interventional clinical trials:

(show all 41)
# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Not yet recruiting NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
2 Otiprio Versus Ciprodex Tympanostomy Tube Outcomes Not yet recruiting NCT03347461 Phase 4 Otiprio;Ciprodex
3 Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes Completed NCT00579189 Phase 3 Moxidex otic solution;Moxifloxacin otic solution
4 Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) - Study 2 Completed NCT02436304 Phase 3 EXE844 Sterile Otic Suspension, 0.3%
5 A Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes Completed NCT00578474 Phase 3 Moxidex otic solution;Ofloxacin otic solution
6 Open-Label Study of OTO-201 in Pediatric Subjects With a History of Otitis Media Requiring Tympanostomy Tubes Completed NCT02600559 Phase 3 OTO-201 (ciprofloxacin)
7 Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) Completed NCT02432105 Phase 3 EXE844 Sterile Otic Suspension, 0.3%
8 Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle Ear Infections in Pediatric Patients Completed NCT01404611 Phase 3 DF289;DF277;DF289 plus DF277
9 Clinical Study to Assess the Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle Ear Infections in Pediatric Patients Completed NCT01395966 Phase 3 DF289;DF277;DF289 plus DF277
10 OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement Completed NCT01949155 Phase 3 OTO-201;Sham
11 OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement Completed NCT01949142 Phase 3 OTO-201;Sham
12 A Comparative Study Between Two Formulations of the Ciprofloxacin Hydrochloride + Hydrocortisone Otic Suspension Completed NCT00980876 Phase 3 Cipro HC;Ciprofloxacin HCl and Hydrocortisone
13 Clinical Study to Assess the Efficacy and Safety of G238 Compared to Clotrimazole Otic Solution in the Treatment of Otomycosis Completed NCT01993823 Phase 3 G238;Clotrimazole
14 Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Acute Otitis Externa Recruiting NCT03196973 Phase 3 DF289 plus DF277;DF289;DF277
15 Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media Active, not recruiting NCT02567825 Phase 3
16 Safety and Efficacy of Moxidex Otic Terminated NCT01071902 Phase 3 Moxidex otic solution;Moxifloxacin otic solution
17 Bioequivalence of Two Ciprofloxacin 0.3%/Dexamethasone 0.1% Sterile Otic Suspensions in Otitis Media in Children With Tympanostomy Tubes Terminated NCT01994642 Phase 3 Ciprofloxacin 0.3%/dexamethasone 0.1% sterile otic suspension;CIPRODEX® (ciprofloxacin 0.3%/dexamethasone 0.1%);Placebo Sterile Otic Suspension
18 A Phase II Study of an Otic Formulation in Treating Peri-Operative Tube Otorrhea Completed NCT00578773 Phase 2 Moxidex otic solution;Moxifloxacin otic solution
19 Open-Label Study of OTO-201 for Treatment of AOMT Completed NCT02408796 Phase 2 OTO-201
20 Dose Ranging Study of OTO-201 in AOMT Completed NCT02719158 Phase 2 6 mg ciprofloxacin;12 mg ciprofloxacin
21 Efficacy and Safety of Once-Daily Ciprodexa Otic Foam Compared to Twice-daily Ciprodex Ear Drops in Acute Otitis Externa Completed NCT01359098 Phase 2 Ciprodex Otic Suspension;Ciprodexa Otic Foam
22 Evaluation of a Vaccine for Reducing Ear and Lung Infections in Children Completed NCT01545375 Phase 2
23 OTO-201 for the Treatment of Otitis Externa Completed NCT02511561 Phase 2 OTO-201 (ciprofloxacin)
24 A Clinical Trial of YH1177 in Patients With Otitis Media and Otorrhea Active, not recruiting NCT02817347 Phase 1, Phase 2 piperacillin 4% + tazobactam 0.5% + dexamethasone 0.1%;piperacillin 8% + tazobactam 1.0% + dexamethasone 0.1%;piperacillin 2% + tazobactam 0.25%;piperacillin 4% + tazobactam 0.5%;piperacillin 8% + tazobactam 1.0%
25 Proof-of-Concept Study of a Single Application of an Investigational Otic Suspension in Treatment of Acute Otitis Media With Tympanostomy Tubes Terminated NCT01908803 Phase 2 AL-60371/AL-817 otic suspension;Ciprofloxacin 0.3%/dexamethasone 0.1% otic suspension
26 OTO-201 for Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement Completed NCT01755286 Phase 1 OTO-201;Placebo;Sham
27 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media Completed NCT00189098 Not Applicable Sulfamethoxazole-trimethoprim;Placebo
28 Study to Identify and Characterize Bacteria Causing Acute Otitis Media in South African Children Completed NCT01031082
29 Microbiology of Otitis Media in Costarrican Children After PCV13 Introduction Completed NCT02096848
30 Topical Treatment of Acute Otitis Media Through Tympanostomy Tubes (AOMT) and Its Effect on Microbial Flora Completed NCT01027494 Ciprofloxacin 0.3% and dexamethasone 0.1% otic suspension
31 Study to Identify and Characterize the Bacteria Causing Acute Otitis Media Episodes in Young Children in Saudi Arabia Completed NCT01204385
32 Addressing Barriers to Adult Hearing Healthcare Recruiting NCT02928107 Not Applicable
33 The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis Not yet recruiting NCT03456739
34 PROtein S100B for Mild Trauma of the HEad in Emergency Patients Not yet recruiting NCT03313505
35 Evaluation of Prognostic Factors in Tympanoplasty Not yet recruiting NCT03416725
36 Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following Radiotherapy Not yet recruiting NCT02716376 Not Applicable
37 Natural History Study of Incidence of Otorrhea Following Tympanostomy Tube Insertion in Children 6 Months to 12 Years Terminated NCT01111877
38 Study to Identify and Characterize the Bacteria Causing Acute Otitis Media Episodes in Young Children in Taiwan Terminated NCT01072227
39 Evaluation of a New Biocompatible Pressure Equalizing Tube Withdrawn NCT01775709 Not Applicable
40 Study to Identify and Characterize Bacteria Causing Acute Otitis Media in Young Children in Turkey Withdrawn NCT01031329
41 Study to Characterize and Identify Bacteria Causing Acute Otitis Media in Young Egyptian Children Withdrawn NCT01160055

Search NIH Clinical Center for Discharging Ear

Genetic Tests for Discharging Ear

Anatomical Context for Discharging Ear

MalaCards organs/tissues related to Discharging Ear:

41
Lung

Publications for Discharging Ear

Articles related to Discharging Ear:

(show all 28)
# Title Authors Year
1
Blind Sac Closure: A safe and effective management option for the chronically discharging ear. ( 26865529 )
2016
2
Chronic discharging ear and multiple cranial nerve pareses: A sinister liaison. ( 25923287 )
2015
3
Chronic discharging ear in a child: are we missing something? ( 24145273 )
2013
4
Comparison of bacteriology in bilaterally discharging ears in chronic suppurative otitis media. ( 23120703 )
2010
5
Optimum management of the discharging ear. ( 1372220 )
1992
6
The discharging ear in the tropics: a guide to diagnosis and management in the district hospital. ( 1542941 )
1992
7
GPs' diagnosis and management of the discharging ear. ( 1296586 )
1992
8
The chronically discharging ear. ( 1454706 )
1992
9
The diagnosis and management of the discharging ear. ( 2602312 )
1989
10
Management of Chronic discharging ear. ( 2807465 )
1989
11
Treating the discharging ear in general practice. ( 3135039 )
1988
12
Survey of general practitioners' treatment of the discharging ear. ( 3135058 )
1988
13
The chronic discharging ear in Nigeria. ( 6693812 )
1984
14
The discharging ear. ( 6639496 )
1983
15
Discharging ear--a problem for the practitioner. ( 7175196 )
1982
16
The discharging ear. ( 5309287 )
1969
17
Topical therapy in the treatment of the discharging ear. ( 5906693 )
1966
18
Surgical cure of chronically discharging ear previously subjected to mastoidectomy. ( 13702162 )
1960
19
Advances in preservation of hearing of the chronically discharging ear. ( 14428205 )
1959
20
THE CHRONIC discharging ear: status of surgical and nonsurgical treatment. ( 13562115 )
1958
21
The chronic discharging ear. ( 13330846 )
1956
22
The chronic discharging ear. ( 13279376 )
1955
23
The management of the chronically discharging ear requiring radical mastoidectomy. ( 14362327 )
1955
24
The discharging ear in general practice. ( 13215264 )
1954
25
The treatment of the chronic discharging ear. ( 13099571 )
1953
26
The insert hearing-aid in a discharging ear. ( 12991753 )
1952
27
The chronically discharging ear; medical management. ( 14861072 )
1951
28
Surgery of the chronically discharging ear. ( 18151623 )
1949

Variations for Discharging Ear

Expression for Discharging Ear

Search GEO for disease gene expression data for Discharging Ear.

Pathways for Discharging Ear

Pathways related to Discharging Ear according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.82 FLNA MCF2
2 11.11 FLNA MCF2

GO Terms for Discharging Ear

Sources for Discharging Ear

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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