MCID: DSC001
MIFTS: 18

Discharging Ear

Categories: Ear diseases

Aliases & Classifications for Discharging Ear

MalaCards integrated aliases for Discharging Ear:

Name: Discharging Ear 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:10261
ICD10 33 H92.1 H92.10
ICD9CM 35 388.6 388.60
NCIt 50 C35199
SNOMED-CT 68 65668001
UMLS 73 C0155540

Summaries for Discharging Ear

MalaCards based summary : Discharging Ear is related to otitis media and langerhans cell histiocytosis. An important gene associated with Discharging Ear is MCF2 (MCF.2 Cell Line Derived Transforming Sequence). The drugs Dexamethasone acetate and Ciprofloxacin have been mentioned in the context of this disorder.

Related Diseases for Discharging Ear

Diseases related to Discharging Ear via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 otitis media 9.8
2 langerhans cell histiocytosis 9.8
3 suppurative otitis media 9.8
4 histiocytosis 9.8

Symptoms & Phenotypes for Discharging Ear

Drugs & Therapeutics for Discharging Ear

Drugs for Discharging Ear (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 81)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 1177-87-3
2
Ciprofloxacin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 85721-33-1 2764
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
4
Levofloxacin Approved, Investigational Phase 4,Phase 3 100986-85-4 149096
5
Ofloxacin Approved Phase 4,Phase 3 82419-36-1 4583
6
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
7 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
8 Hormones Phase 4,Phase 3,Phase 2,Phase 1
9 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
10 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
14 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1
15 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
16 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 HIV Protease Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
18 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
19
protease inhibitors Phase 4,Phase 3,Phase 2,Phase 1
20 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1
21 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
22 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
24 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
25 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
26 Anti-Infective Agents, Urinary Phase 4,Phase 3,Not Applicable
27 Renal Agents Phase 4,Phase 3,Not Applicable
28 Antibiotics, Antitubercular Phase 4,Phase 3
29 Fluoroquinolones Phase 4,Phase 3,Phase 2
30 Expectorants Phase 4
31 Protective Agents Phase 4
32 Free Radical Scavengers Phase 4
33 N-monoacetylcystine Phase 4
34 Antioxidants Phase 4
35 Antiviral Agents Phase 4
36 Respiratory System Agents Phase 4
37 Antidotes Phase 4
38
Polyestradiol phosphate Approved Phase 3,Phase 2 28014-46-2
39
Moxifloxacin Approved, Investigational Phase 3,Phase 2 354812-41-2, 151096-09-2 152946
40 Estradiol valerate Approved, Investigational, Vet_approved Phase 3,Phase 2 979-32-8
41
Ethinyl Estradiol Approved Phase 3,Phase 2 57-63-6 5991
42
Estradiol Approved, Investigational, Vet_approved Phase 3,Phase 2 50-28-2 5757
43
Norgestimate Approved, Investigational Phase 3,Phase 2 35189-28-7 6540478
44
Hydrocortisone acetate Approved, Vet_approved Phase 3 50-03-3
45
Hydrocortisone Approved, Vet_approved Phase 3 50-23-7 5754
46
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
47
Dipivefrin Approved Phase 3,Phase 2 52365-63-6 3105
48 Contraceptives, Oral, Combined Phase 3,Phase 2
49 Estradiol 17 beta-cypionate Phase 3,Phase 2
50 Contraceptive Agents Phase 3,Phase 2

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media Not yet recruiting NCT00956748 Phase 4 Ciprodex;Ciprodex and 2% NAC
2 Does Topical Otic Drop Use at Time of Tympanostomy Tube Surgery Improve Outcomes When no Middle Ear Effusion is Present Not yet recruiting NCT03655665 Phase 4 Ofloxacin otic solution
3 Otiprio Versus Ciprodex Tympanostomy Tube Outcomes Withdrawn NCT03347461 Phase 4 Otiprio;Ciprodex
4 Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes Completed NCT00579189 Phase 3 Moxidex otic solution;Moxifloxacin otic solution
5 Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) - Study 2 Completed NCT02436304 Phase 3 EXE844 Sterile Otic Suspension, 0.3%
6 A Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes Completed NCT00578474 Phase 3 Moxidex otic solution;Ofloxacin otic solution
7 Open-Label Study of OTO-201 in Pediatric Subjects With a History of Otitis Media Requiring Tympanostomy Tubes Completed NCT02600559 Phase 3 OTO-201 (ciprofloxacin)
8 Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) Completed NCT02432105 Phase 3 EXE844 Sterile Otic Suspension, 0.3%
9 Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle Ear Infections in Pediatric Patients Completed NCT01404611 Phase 3 DF289;DF277;DF289 plus DF277
10 Clinical Study to Assess the Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle Ear Infections in Pediatric Patients Completed NCT01395966 Phase 3 DF289;DF277;DF289 plus DF277
11 OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement Completed NCT01949155 Phase 3 OTO-201;Sham
12 OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement Completed NCT01949142 Phase 3 OTO-201;Sham
13 A Comparative Study Between Two Formulations of the Ciprofloxacin Hydrochloride + Hydrocortisone Otic Suspension Completed NCT00980876 Phase 3 Cipro HC;Ciprofloxacin HCl and Hydrocortisone
14 Clinical Study to Assess the Efficacy and Safety of G238 Compared to Clotrimazole Otic Solution in the Treatment of Otomycosis Completed NCT01993823 Phase 3 G238;Clotrimazole
15 Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Acute Otitis Externa Recruiting NCT03196973 Phase 3 DF289 plus DF277;DF289;DF277
16 Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media Active, not recruiting NCT02567825 Phase 3
17 Safety and Efficacy of Moxidex Otic Terminated NCT01071902 Phase 3 Moxidex otic solution;Moxifloxacin otic solution
18 Bioequivalence of Two Ciprofloxacin 0.3%/Dexamethasone 0.1% Sterile Otic Suspensions in Otitis Media in Children With Tympanostomy Tubes Terminated NCT01994642 Phase 3 Ciprofloxacin 0.3%/dexamethasone 0.1% sterile otic suspension;CIPRODEX® (ciprofloxacin 0.3%/dexamethasone 0.1%);Placebo Sterile Otic Suspension
19 A Phase II Study of an Otic Formulation in Treating Peri-Operative Tube Otorrhea Completed NCT00578773 Phase 2 Moxidex otic solution;Moxifloxacin otic solution
20 Open-Label Study of OTO-201 for Treatment of AOMT Completed NCT02408796 Phase 2 OTO-201
21 Dose Ranging Study of OTO-201 in AOMT Completed NCT02719158 Phase 2 6 mg ciprofloxacin;12 mg ciprofloxacin
22 Efficacy and Safety of Once-Daily Ciprodexa Otic Foam Compared to Twice-daily Ciprodex Ear Drops in Acute Otitis Externa Completed NCT01359098 Phase 2 Ciprodex Otic Suspension;Ciprodexa Otic Foam
23 Evaluation of a Vaccine for Reducing Ear and Lung Infections in Children Completed NCT01545375 Phase 2
24 OTO-201 for the Treatment of Otitis Externa Completed NCT02511561 Phase 2 OTO-201 (ciprofloxacin)
25 A Clinical Trial of YH1177 in Patients With Otitis Media and Otorrhea Active, not recruiting NCT02817347 Phase 1, Phase 2 piperacillin 4% + tazobactam 0.5% + dexamethasone 0.1%;piperacillin 8% + tazobactam 1.0% + dexamethasone 0.1%;piperacillin 2% + tazobactam 0.25%;piperacillin 4% + tazobactam 0.5%;piperacillin 8% + tazobactam 1.0%
26 Proof-of-Concept Study of a Single Application of an Investigational Otic Suspension in Treatment of Acute Otitis Media With Tympanostomy Tubes Terminated NCT01908803 Phase 2 AL-60371/AL-817 otic suspension;Ciprofloxacin 0.3%/dexamethasone 0.1% otic suspension
27 OTO-201 for Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement Completed NCT01755286 Phase 1 OTO-201;Placebo;Sham
28 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media Completed NCT00189098 Not Applicable Sulfamethoxazole-trimethoprim;Placebo
29 Study to Identify and Characterize Bacteria Causing Acute Otitis Media in South African Children Completed NCT01031082
30 Microbiology of Otitis Media in Costarrican Children After PCV13 Introduction Completed NCT02096848
31 Topical Treatment of Acute Otitis Media Through Tympanostomy Tubes (AOMT) and Its Effect on Microbial Flora Completed NCT01027494 Ciprofloxacin 0.3% and dexamethasone 0.1% otic suspension
32 Study to Identify and Characterize the Bacteria Causing Acute Otitis Media Episodes in Young Children in Saudi Arabia Completed NCT01204385
33 Addressing Barriers to Adult Hearing Healthcare Active, not recruiting NCT02928107 Not Applicable
34 The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis Not yet recruiting NCT03456739
35 PROtein S100B for Mild Trauma of the HEad in Emergency Patients Not yet recruiting NCT03313505
36 Evaluation of Prognostic Factors in Tympanoplasty Not yet recruiting NCT03416725
37 Treatment and Prevention of Middle Ear Morbidity in Head and Neck Cancer Patients Following Radiotherapy Not yet recruiting NCT02716376 Not Applicable
38 Natural History Study of Incidence of Otorrhea Following Tympanostomy Tube Insertion in Children 6 Months to 12 Years Terminated NCT01111877
39 Study to Identify and Characterize the Bacteria Causing Acute Otitis Media Episodes in Young Children in Taiwan Terminated NCT01072227
40 Evaluation of a New Biocompatible Pressure Equalizing Tube Withdrawn NCT01775709 Not Applicable
41 Study to Identify and Characterize Bacteria Causing Acute Otitis Media in Young Children in Turkey Withdrawn NCT01031329
42 Study to Characterize and Identify Bacteria Causing Acute Otitis Media in Young Egyptian Children Withdrawn NCT01160055

Search NIH Clinical Center for Discharging Ear

Genetic Tests for Discharging Ear

Anatomical Context for Discharging Ear

Publications for Discharging Ear

Articles related to Discharging Ear:

(show all 27)
# Title Authors Year
1
Blind sac closure: a safe and effective management option for the chronically discharging ear. ( 26865529 )
2017
2
Chronic discharging ear and multiple cranial nerve pareses: A sinister liaison. ( 25923287 )
2015
3
Chronic discharging ear in a child: are we missing something? ( 24145273 )
2013
4
Optimum management of the discharging ear. ( 1372220 )
1992
5
The discharging ear in the tropics: a guide to diagnosis and management in the district hospital. ( 1542941 )
1992
6
GPs' diagnosis and management of the discharging ear. ( 1296586 )
1992
7
The chronically discharging ear. ( 1454706 )
1992
8
The diagnosis and management of the discharging ear. ( 2602312 )
1989
9
Management of Chronic discharging ear. ( 2807465 )
1989
10
Treating the discharging ear in general practice. ( 3135039 )
1988
11
Survey of general practitioners' treatment of the discharging ear. ( 3135058 )
1988
12
The chronic discharging ear in Nigeria. ( 6693812 )
1984
13
The discharging ear. ( 6639496 )
1983
14
Discharging ear--a problem for the practitioner. ( 7175196 )
1982
15
The discharging ear. ( 5309287 )
1969
16
Topical therapy in the treatment of the discharging ear. ( 5906693 )
1966
17
Surgical cure of chronically discharging ear previously subjected to mastoidectomy. ( 13702162 )
1960
18
Advances in preservation of hearing of the chronically discharging ear. ( 14428205 )
1959
19
THE CHRONIC discharging ear: status of surgical and nonsurgical treatment. ( 13562115 )
1958
20
The chronic discharging ear. ( 13330846 )
1956
21
The chronic discharging ear. ( 13279376 )
1955
22
The management of the chronically discharging ear requiring radical mastoidectomy. ( 14362327 )
1955
23
The discharging ear in general practice. ( 13215264 )
1954
24
The treatment of the chronic discharging ear. ( 13099571 )
1953
25
The insert hearing-aid in a discharging ear. ( 12991753 )
1952
26
The chronically discharging ear; medical management. ( 14861072 )
1951
27
Surgery of the chronically discharging ear. ( 18151623 )
1949

Variations for Discharging Ear

Expression for Discharging Ear

Search GEO for disease gene expression data for Discharging Ear.

Pathways for Discharging Ear

GO Terms for Discharging Ear

Sources for Discharging Ear

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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