Aliases & Classifications for Discitis

MalaCards integrated aliases for Discitis:

Name: Discitis 12 44 15 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:10986
MeSH 44 D015299
SNOMED-CT 67 2304001
ICD10 32 M46.4
UMLS 70 C0012624

Summaries for Discitis

MalaCards based summary : Discitis is related to osteomyelitis and spondylolisthesis. An important gene associated with Discitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Chondroitin sulfate/dermatan sulfate metabolism and Diseases of glycosylation. The drugs Antibiotics, Antitubercular and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and spinal cord.

Wikipedia : 73 Discitis, or diskitis, is an infection in the intervertebral disc space that affects different age... more...

Related Diseases for Discitis

Diseases related to Discitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 osteomyelitis 31.3 CRP CALCA
2 spondylolisthesis 30.6 CRP ACAN
3 septic arthritis 30.4 CRP CALCA
4 neurogenic arthropathy 30.2 CRP CALCA
5 pyelonephritis 30.2 CRP CALCA
6 acute pyelonephritis 29.9 CRP CALCA
7 pyomyositis 29.9 TST CRP
8 exostosis 29.9 CALCA ACAN
9 spinal stenosis 29.9 CALCA ACAN
10 degenerative disc disease 29.8 CALCA ACAN
11 back pain 10.5
12 epidural abscess 10.5
13 inflammatory spondylopathy 10.4
14 spondylitis 10.4
15 endocarditis 10.4
16 sepsis in premature infants 10.3 CRP CALCA
17 external ear carcinoma 10.3 CRP CALCA
18 plantar fasciitis 10.3 CRP CALCA
19 acute cholangitis 10.2 CRP CALCA
20 bursitis 10.2 CRP CALCA
21 suppurative thyroiditis 10.2 CRP CALCA
22 thyroiditis 10.2 CRP CALCA
23 raynaud disease 10.2 CRP CALCA
24 chronic pyelonephritis 10.2 CRP CALCA
25 spondyloarthropathy 1 10.2
26 infective endocarditis 10.2
27 erysipelas 10.2 CRP CALCA
28 chondromalacia 10.2 CRP ACAN
29 decubitus ulcer 10.2 CRP CALCA
30 enthesopathy 10.2 CRP ACAN
31 epicondylitis 10.2 CALCA ACAN
32 spondylosis 10.2 CRP ACAN
33 cartilage disease 10.2 CRP ACAN
34 viral meningitis 10.2 CRP CALCA
35 bone deterioration disease 10.2 CALCA ACAN
36 nodular goiter 10.2 CRP CALCA
37 scarlet fever 10.2 TST CRP
38 aseptic meningitis 10.2 CRP CALCA
39 mineral metabolism disease 10.2 CRP CALCA
40 ischemic bone disease 10.2 CALCA ACAN
41 bacterial sepsis 10.2 CRP CALCA
42 necrotizing fasciitis 10.2 TST CRP
43 agnosia 10.2 CRP CALCA
44 impetigo 10.1 TST CALCA
45 radiculopathy 10.1
46 endocardium disease 10.1 TST CRP
47 carbuncle 10.1 TXNDC12 TST
48 ileus 10.1 CRP CALCA
49 hypochondrogenesis 10.1 FMOD ACAN
50 aortic aneurysm 10.1

Graphical network of the top 20 diseases related to Discitis:



Diseases related to Discitis

Symptoms & Phenotypes for Discitis

Drugs & Therapeutics for Discitis

Drugs for Discitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibiotics, Antitubercular Phase 4
2 Anti-Bacterial Agents Phase 4
3 Anti-Infective Agents Phase 4
4 Pharmaceutical Solutions
5 Fluorodeoxyglucose F18

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Comparison of Two Antimicrobial Therapy Duration (6 Weeks Versus 12 Weeks)for Spondylodiscitis Completed NCT00764114 Phase 4 antibiotic
2 Unilateral Posterolateral Approach for Disc Debridement and Titanium Cage Insertion Supplemented by Contralateral Transfascial Screw Fixation for Sick Patients Suffering From Septic Thoracolumbosacral Spondylodiscitis Completed NCT03472131
3 Accuracy, Safety and Diagnostic Outcome of Percutaneous Fluoroscopic vs. CT Guided Transpedicular Core Needle Biopsy for Spinal Infections and Tumors. A Prospective Randomized Trial Completed NCT03585699
4 SPONDIMMO : Multicentered Descriptive Prospective Study of Immobilization and Neurological Complication in Patients With Vertebral Osteomyelitis. Completed NCT04655950
5 Verification and Progress of Cytokine Profiles and suPAR for the Discrimination of Infectious and Non-infectious, Degenerative Diseases of the Spine Completed NCT02554227
6 Comparison of Thoracolumbar Back Pain After Brace Treatment Versus Percutaneous Instrumentation in Adult Pyogenic Spondylodiscitis Combined With Antibiotic Treatment Recruiting NCT03524209
7 The European Robotic Spinal Instrumentation (EUROSPIN) Study: A European Prospective Multicenter Multinational Pragmatic Trial on Robot-guided Versus Navigated Versus Freehand Pedicle Screw Fixation Recruiting NCT03398915
8 Subclinical Propionibacterium Acnes Infection Estimation in the Intervertebral Disc (SPInE-ID): a Prospective Cohort Active, not recruiting NCT03158766
9 Long Term Follow up of Patients With Thoracolumbar Spondylodiscitis Treated Surgically by Posterior Approach in Assiut University Hospitals Not yet recruiting NCT04749082
10 Conservative Versus Surgical Treatment of Native Vertebral Osteomyelitis: a Randomized Multicentre Trial Not yet recruiting NCT04436328
11 Preliminary Study. The Value of 18F-FDG PET/CT Compared to MRI in Diagnosing Residual Disease in Patients With Spondylodiscitis Suspended NCT01542853

Search NIH Clinical Center for Discitis

Cochrane evidence based reviews: discitis

Genetic Tests for Discitis

Anatomical Context for Discitis

MalaCards organs/tissues related to Discitis:

40
Bone, Prostate, Spinal Cord, Bone Marrow, Eye, Heart, Liver

Publications for Discitis

Articles related to Discitis:

(show top 50) (show all 951)
# Title Authors PMID Year
1
Posterior stabilisation without formal debridement for the treatment of non-tuberculous pyogenic spinal infection in frail and debilitated population - A systematic review and meta-analysis. 61
33717910 2021
2
Percutaneous wide bore needle biopsy for spinal lesions using the kyphoplasty cannula-a technical note. 61
33772382 2021
3
Three-dimensional ultrashort echo time (3D UTE) magnetic resonance imaging (MRI) of the normal and degenerative disco-vertebral complex at 4.7 T: a feasibility study with longitudinal evaluation. 61
33609189 2021
4
An unusual case of Cardiobacterium valvarum causing aortic endograft infection and osteomyelitis. 61
33639961 2021
5
Clinicoradiographic predictors of percutaneous bone biopsy results among patients with suspected thoracolumbar spine infection. 61
33576862 2021
6
Fatal epidural abscess from diabetic foot disease. 61
33566794 2021
7
Severe Group C Streptococcus infection in a veterinarian. 61
33552899 2021
8
Defining Disc Biopsy Timing in Relation to Blood Culture Results for Inpatients with Suspected Discitis-Osteomyelitis. 61
33132028 2021
9
Incidence of Sacral Osteomyelitis and Discitis After Minimally Invasive Sacrocolpopexy. 61
33534268 2021
10
A Case of Osteodiscitis in a Preschool-Aged Child. 61
33628693 2021
11
Full endoscopic surgery for thoracic pathology: an assessment of supportive evidence. 61
33532086 2021
12
Radiographic and clinical features of thoracic disk disease associated with myelopathy: a retrospective analysis of 257 cases. 61
33389202 2021
13
Lumbar Disc Herniation and Preoperative Modic Changes: A Prospective Analysis of the Clinical Outcomes After Microdiscectomy. 61
33461335 2021
14
Prognosis of spinal infections managed by minimal debridement: A case series in two tertiary centers. 61
33767887 2021
15
Video-assisted thoracoscopic image-guided spine surgery: evolution of 19 years of experience, from endoscopy to fully integrated 3D navigation. 61
33386009 2021
16
A 64-Year-Old Man with Low Back Pain Due to Clostridium perfringens Lumbar Discitis. 61
33479190 2021
17
Management of post-operative discitis following discectomy in a tertiary-level hospital. 61
33570021 2021
18
Limited Clinical Utility of Follow-up Blood Cultures in Patients With Streptococcal Bacteremia: An Opportunity for Blood Culture Stewardship. 61
33364258 2020
19
Rifampin-Associated Flu-Like Syndrome in a Patient Undergoing Treatment for a Device-Related Infection. 61
33520532 2020
20
Best Practices: CT-Guided Percutaneous Sampling of Vertebral Discitis-Osteomyelitis and Technical Factors Maximizing Biopsy Yield. 61
33336581 2020
21
Discitis following urinary tract infection manifesting as recurrent autonomic dysreflexia related to truncal movements in a person with tetraplegia. 61
33334762 2020
22
Does image-guided biopsy of discitis-osteomyelitis provide meaningful information to impact clinical management? 61
33230728 2020
23
Pyogenic psoas abscess on the dorsal side, and bacterial meningitis and spinal epidural abscess on the ventral side, both of which were induced by spontaneous discitis in a patient with diabetes mellitus: A case report. 61
33179391 2020
24
Lumbosacral discitis as a rare complication of laparoscopic sacrocolpopexy. 61
32500164 2020
25
A Rare Cause of Acute Back Pain in a Young Adult: Case Report and Discussion of Calcific Discitis. 61
33708337 2020
26
Duration of antibiotics for penetrating spine trauma: a systematic review. 61
33102898 2020
27
Non tuberculous mycobacteria related spondylodiscitis: a case report and systematic literature review. 61
32920580 2020
28
[Antibiotics should not be used to treat patients with back/leg pain]. 61
32969480 2020
29
Modic changes - An evidence-based, narrative review on its patho-physiology, clinical significance and role in chronic low back pain. 61
32879563 2020
30
CT-guided discitis-osteomyelitis biopsies: needle gauge and microbiology results. 61
32306072 2020
31
Change in Bone CT Attenuation and C-reactive Protein Are Predictors of Bone Biopsy Culture Positivity in Patients With Vertebral Discitis/Osteomyelitis. 61
32205702 2020
32
Osteomyelitis-Discitis at the Thoracolumbar Junction and the Development of Postinfectious Spinal Deformity: A Surgical Case Series. 61
32986577 2020
33
Chronic Infectious Complications of Recreational Urethral Sounding With Retained Foreign Body. 61
32944465 2020
34
[Evidence-based implant choice in infections of the spine : Is it a gut thing, after all?] 61
32661896 2020
35
Chronic Rhinotillexomania Leading to Multiple Infectious Sequelae in a 66-Year-Old Female. 61
32963898 2020
36
Conservative versus operative management of postoperative lumbar discitis. 61
33100770 2020
37
A Case Report of Rapid Aseptic Intervertebral Disc Destruction After Lumbar Microdiscectomy: A Case Report. 61
32668140 2020
38
Lumbar Discitis and Osteomyelitis After a Spinal Stem Cell Injection?: A Case Report and Literature Review. 61
32773702 2020
39
Lactobacillus Discitis/Osteomyelitis in an Intravenous Drug Abuser. 61
32821570 2020
40
[The Facet Wedge: a minimally invasive technique for posterior segmental intra-articular fusion]. 61
32179944 2020
41
Posterior Grade 4 Osteotomy With Vertebral Shortening Is Effective for the Treatment of Kyphosis Associated With Vertebral Discitis/Osteomyelitis. 61
32699751 2020
42
Pyogenic discitis with an epidural abscess after cervical analgesic discography: A case report. 61
32548162 2020
43
Paediatric spondylodiscitis: a 10-year single institution experience in management and clinical outcomes. 61
31848723 2020
44
Bacteroides Fragilis Vertebral Osteomyelitis and Discitis: "Back" to Susceptibility Testing. 61
32454579 2020
45
Antibiotic-impregnated polymethylmethacrylate strut graft as a treatment of spinal osteomyelitis: case series and description of novel technique. 61
32384277 2020
46
Subacute Presentation of Central Cord Syndrome Resulting from Vertebral Osteomyelitis and Discitis: A Case Report. 61
32426690 2020
47
Vague neck pain following a gastrointestinal procedure: a rare case presentation of vertebral osteomyelitis and cervical epidural abscess. 61
32404877 2020
48
A unusual case of multifocal pyogenic abscess formation following ERCP procedure. 61
32375832 2020
49
CT-guided discitis-osteomyelitis biopsies with negative microbiology: how many days should we wait before repeating the biopsy? 61
31760457 2020
50
MRI and clinical features of acute fungal discitis/osteomyelitis. 61
31900707 2020

Variations for Discitis

Expression for Discitis

Search GEO for disease gene expression data for Discitis.

Pathways for Discitis

Pathways related to Discitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.05 VCAN FMOD ACAN
2
Show member pathways
11.3 VCAN FMOD ACAN
3 10.91 VCAN ACAN
4 10.81 FMOD ACAN
5 10.56 VCAN FMOD ACAN
6
Show member pathways
10.48 FMOD ACAN

GO Terms for Discitis

Cellular components related to Discitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 VCAN TST FMOD CRP CALCA
2 extracellular region GO:0005576 9.63 VCAN FMOD CRP CALCA ARSJ ACAN
3 collagen-containing extracellular matrix GO:0062023 9.58 VCAN FMOD ACAN
4 endoplasmic reticulum lumen GO:0005788 9.5 VCAN TXNDC12 ARSJ
5 extracellular matrix GO:0031012 9.43 VCAN FMOD ACAN
6 Golgi lumen GO:0005796 9.13 VCAN FMOD ACAN
7 lysosomal lumen GO:0043202 8.8 VCAN FMOD ACAN

Biological processes related to Discitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen fibril organization GO:0030199 9.16 FMOD ACAN
2 keratan sulfate biosynthetic process GO:0018146 8.96 FMOD ACAN
3 keratan sulfate catabolic process GO:0042340 8.62 FMOD ACAN

Molecular functions related to Discitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hyaluronic acid binding GO:0005540 8.96 VCAN ACAN
2 extracellular matrix structural constituent conferring compression resistance GO:0030021 8.8 VCAN FMOD ACAN

Sources for Discitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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