MCID: DSC009
MIFTS: 48

Discoid Lupus Erythematosus

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Discoid Lupus Erythematosus

MalaCards integrated aliases for Discoid Lupus Erythematosus:

Name: Discoid Lupus Erythematosus 59
Lupus Erythematosus, Discoid 73
Lupus Erythematosus Discoid 55

Characteristics:

Orphanet epidemiological data:

59
discoid lupus erythematosus
Prevalence: 1-9/100000 (United States);

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Orphanet 59 ORPHA90281
MESH via Orphanet 45 D008179
UMLS via Orphanet 74 C0024138
ICD10 via Orphanet 34 L93.0
ICD10 33 L93.0
UMLS 73 C0024138

Summaries for Discoid Lupus Erythematosus

MalaCards based summary : Discoid Lupus Erythematosus, also known as lupus erythematosus, discoid, is related to lichen planus and keratoacanthoma, and has symptoms including pruritus, exanthema and heliotrope rash. An important gene associated with Discoid Lupus Erythematosus is IFNA2 (Interferon Alpha 2), and among its related pathways/superpathways are Allograft rejection and Keratinization. Affiliated tissues include skin, testes and t cells.

Wikipedia : 76 Discoid lupus erythematosus (DLE) is a chronic skin condition of sores with inflammation and scarring... more...

Related Diseases for Discoid Lupus Erythematosus

Diseases related to Discoid Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 lichen planus 30.6 FLG GZMB IVL KRT10 KRT16
2 keratoacanthoma 30.4 FLG GZMB KRT10 KRT16
3 lichen sclerosus 30.4 GZMB HLA-DRB1
4 keratosis 30.4 FLG IVL KRT10
5 contact dermatitis 30.3 FLG IL10 IVL KRT16
6 psoriasis 30.1 FLG IL10 IVL KRT10 KRT16
7 connective tissue disease 30.1 APOH HLA-DRB1 IL10
8 polyarteritis nodosa 30.1 APOH IFNA2
9 allergic contact dermatitis 29.9 FLG IL10 NAT2
10 mixed connective tissue disease 29.9 APOH HLA-DRB1 IL10
11 viral infectious disease 29.9 IFNA1 IFNA2 IL10
12 discoid lupus erythematosus of eyelid 12.4
13 lupus erythematosus 11.8
14 pseudopelade of brocq 11.4
15 squamous cell carcinoma 10.8
16 systemic lupus erythematosus 10.7
17 alopecia 10.6
18 dermatitis 10.5
19 chronic granulomatous disease 10.5
20 cutaneous lupus erythematosus 10.4
21 scleroderma, familial progressive 10.4
22 granulomatous disease, chronic, x-linked 10.4
23 porphyria 10.4
24 dermatitis herpetiformis, familial 10.3
25 panniculitis 10.3
26 dermatitis herpetiformis 10.3
27 bullous pemphigoid 10.3
28 blepharitis 10.3
29 lupus erythematosus tumidus 10.3
30 rheumatoid arthritis 10.3
31 arthritis 10.3
32 calcinosis 10.3
33 lichen planopilaris 10.3
34 porphyria cutanea tarda 10.2
35 complement component 2 deficiency 10.2
36 antiphospholipid syndrome 10.2
37 adenocarcinoma 10.2
38 herpes zoster 10.2
39 pemphigus 10.2
40 degos 'en cocarde' erythrokeratoderma 10.2
41 frontal fibrosing alopecia 10.2
42 subacute cutaneous lupus erythematosus 10.2
43 lichen disease 10.2 FLG IVL
44 filamentary keratitis 10.2 FLG KRT10
45 irritant dermatitis 10.2 FLG KRT16
46 steatocystoma multiplex 10.2 KRT10 KRT16
47 bowen's disease 10.2 KRT10 KRT16
48 squamous cell carcinoma of the oral tongue 10.2 KRT10 KRT16
49 pinguecula 10.2 KRT10 KRT16
50 ichthyosis vulgaris 10.1 FLG KRT10

Graphical network of the top 20 diseases related to Discoid Lupus Erythematosus:



Diseases related to Discoid Lupus Erythematosus

Symptoms & Phenotypes for Discoid Lupus Erythematosus

UMLS symptoms related to Discoid Lupus Erythematosus:


pruritus, exanthema, heliotrope rash, lupus-like rash

Drugs & Therapeutics for Discoid Lupus Erythematosus

Search Clinical Trials , NIH Clinical Center for Discoid Lupus Erythematosus

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Discoid Lupus Erythematosus

Anatomical Context for Discoid Lupus Erythematosus

MalaCards organs/tissues related to Discoid Lupus Erythematosus:

41
Skin, Testes, T Cells, Lung, Tongue, Thyroid, Bone Marrow

Publications for Discoid Lupus Erythematosus

Articles related to Discoid Lupus Erythematosus:

(show top 50) (show all 726)
# Title Authors Year
1
Computerized planimetry to assess clinical responsiveness in a phase II randomized trial of topical R333 for discoid lupus erythematosus. ( 29336019 )
2018
2
X-linked TLR7 gene polymorphisms are associated with diverse immunological conditions but not with discoid lupus erythematosus in Polish patients. ( 29599669 )
2018
3
Discoid lupus erythematosus following herpes zoster. ( 29894527 )
2018
4
Verrucous Disseminated Discoid Lupus Erythematosus with Plantar and Oral Lesions in the Absence of Systemic Lupus Erthyematosus. ( 29644204 )
2018
5
Pulsed-dye laser as an adjuvant treatment for discoid lupus erythematosus: a randomized, controlled trial. ( 29676592 )
2018
6
A case report of lupus erythematosus tumidus converted from discoid lupus erythematosus. ( 29668590 )
2018
7
JAK-STAT signaling pathway inhibition: a role for treatment of discoid lupus erythematosus and dermatomyositis. ( 29873082 )
2018
8
A rare case with prominent features of both discoid lupus erythematosus and pemphigus foliaceus. ( 29858874 )
2018
9
Multiple primary squamous cell carcinomas of the lower lip and tongue arising in discoid lupus erythematosus: a case report. ( 28967499 )
2018
10
Is chloroquine neuromyotoxicity in a patient with refractory discoid lupus erythematosus potentiated by concomitant use of mepacrine? ( 29808483 )
2018
11
S-1 induced discoid lupus erythematosus-like lesions and long-term complete response for para-aortic lymph node recurrence of pancreatic ductal adenocarcinoma: a case report. ( 29882080 )
2018
12
Lichen Planus Pigmentosus and Frontal Fibrosing Alopecia Mimicking Discoid Lupus Erythematosus. ( 30427589 )
2018
13
Frontal Fibrosing Alopecia and Discoid Lupus Erythematosus: More Than a Coincidence. ( 30482575 )
2018
14
Clinical and dermoscopic spectrum of discoid lupus erythematosus: novel observations from lips and oral mucosa. ( 29700807 )
2018
15
Intravenous Immunoglobulins as a new opportunity to treat discoid lupus erythematosus: A case report and review of the literature. ( 29885539 )
2018
16
Mepacrine-induced interstitial lung disease in discoid lupus erythematosus? ( 30022483 )
2018
17
Chronic Inflammation Promotes Skin Carcinogenesis in Cancer-Prone Discoid Lupus Erythematosus. ( 30030152 )
2018
18
Unilateral Discoid Lupus Erythematosus Over the Face: An Unusual Presentation. ( 30050819 )
2018
19
Coexistence of Tumid Lupus Erythematosus and Discoid Lupus Erythematosus. ( 30072022 )
2018
20
Rapamycin for refractory discoid lupus erythematosus. ( 30109759 )
2018
21
Discoid lupus erythematosus: Reflectance confocal microscopy features correlate with horizontal histopathological sections. ( 30357933 )
2018
22
A comparative immunohistochemical study of epidermal and dermal/perifollicular Langerhans cell concentration in discoid lupus erythematosus and lichen planopilaris: a cross-sectional study. ( 30376791 )
2018
23
Koebner phenomenon of discoid lupus erythematosus on old tattoos. ( 30486728 )
2018
24
Rare cause of periorbital and eyelids lesions: Discoid lupus erythematosus misdiagnosed as allergy. ( 29102423 )
2017
25
Bilateral malar milia en plaque as primary presentation of discoid lupus erythematosus. ( 28337470 )
2017
26
Verrucous discoid lupus erythematosus in a child. ( 28194816 )
2017
27
Diagnostic value of immunohistochemistry staining of Bcl-2, CD34, CD20 and CD3 for distinction between discoid lupus erythematosus and lichen planus in the skin. ( 28631630 )
2017
28
White rosettes in discoid lupus erythematosus: a new dermoscopic observation. ( 29214102 )
2017
29
Incidental Focal Acantholytic Dyskeratosis in a Patient with Discoid Lupus Erythematosus: A Possible Role for SPCA1 in the Pathogenesis of the Disease. ( 28966534 )
2017
30
Blue-White Veil as Novel Dermatoscopic Feature in Discoid Lupus Erythematosus in 2 African-American Patients. ( 29177151 )
2017
31
Eruptive Keratoacanthoma-Like Discoid Lupus Erythematosus. ( 28816744 )
2017
32
Discoid Lupus Erythematosus Presenting as Upper Eyelid Edema and Erythema. ( 28918619 )
2017
33
Classifying discoid lupus erythematosus: background, gaps, and difficulties. ( 28492042 )
2017
34
Intense Pulsed Light and Q-Switched 1,064-nm Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment for the Scarring Lesion of Discoid Lupus Erythematosus. ( 28566911 )
2017
35
High Prevalence of Metabolic Syndrome in Patients with Discoid Lupus Erythematosus: A Cross-Sectional, Case-Control Study. ( 28127570 )
2017
36
Discoid lupus erythematosus: when a superficial injury is a red herring of underlying disease. ( 29038195 )
2017
37
Successful treatment of recalcitrant discoid lupus erythematosus with ustekinumab. ( 28329473 )
2017
38
A Rare Case of Lupus Vulgaris with Papulonecrotic Tuberculid and Discoid Lupus Erythematosus. ( 28836565 )
2017
39
Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome. ( 28626188 )
2017
40
Drugs for discoid lupus erythematosus. ( 28476075 )
2017
41
Development of classification criteria for discoid lupus erythematosus: Results of a Delphi exercise. ( 28606712 )
2017
42
Brief Report: Pharmacodynamics, Safety, and Clinical Efficacy of AMG 811, a Human Anti-Interferon-I^ Antibody, in Patients With Discoid Lupus Erythematosus. ( 28118537 )
2017
43
A rare case of unilateral discoid lupus erythematosus mimicking lupus vulgaris. ( 29122902 )
2017
44
Linear cutaneous lupus erythematosus/discoid lupus erythematosus in an adult. ( 28507499 )
2017
45
Reply to: Direct Immunofluorescence Findings in Discoid Lupus Erythematosus and Bullous Pemphigoid. ( 28323786 )
2017
46
Disseminated discoid lupus erythematosus with a linear lesion on the forearm and hand: A rare presentation and review of literature. ( 28707650 )
2017
47
Generalized Discoid Lupus Erythematosus as the Presenting Sign of Small Cell Lung Carcinoma. ( 28705287 )
2017
48
A retrospective study comparing histopathological and immunopathological features of nasal planum dermatitis in 20 dogs with discoid lupus erythematosus or leishmaniosis. ( 28133824 )
2017
49
Familial discoid lupus erythematosus evolving to systemic lupus erythematosus with lung involvement after more than a decade in older adults. ( 28960709 )
2017
50
Antiphospholipid syndrome with subsequent chronic discoid lupus erythematosus: a case report. ( 27068596 )
2016

Variations for Discoid Lupus Erythematosus

Expression for Discoid Lupus Erythematosus

Search GEO for disease gene expression data for Discoid Lupus Erythematosus.

Pathways for Discoid Lupus Erythematosus

GO Terms for Discoid Lupus Erythematosus

Cellular components related to Discoid Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 APOH ENO3 IFNA1 IFNA2 IL10 KRT10
2 intermediate filament GO:0005882 9.13 FLG KRT10 KRT16
3 cornified envelope GO:0001533 8.8 FLG IVL KRT10

Biological processes related to Discoid Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.69 IVL KRT10 KRT16
2 aging GO:0007568 9.65 ENO3 IL10 KRT16
3 response to exogenous dsRNA GO:0043330 9.52 IFNA1 IFNA2
4 B cell differentiation GO:0030183 9.5 IFNA1 IFNA2 IL10
5 negative regulation of interferon-gamma production GO:0032689 9.49 HLA-DRB1 IL10
6 T cell activation involved in immune response GO:0002286 9.46 IFNA1 IFNA2
7 establishment of skin barrier GO:0061436 9.43 FLG KRT16
8 peptide cross-linking GO:0018149 9.43 FLG IVL KRT10
9 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.4 IFNA1 IFNA2
10 natural killer cell activation involved in immune response GO:0002323 9.37 IFNA1 IFNA2
11 B cell proliferation GO:0042100 9.33 IFNA1 IFNA2 IL10
12 cornification GO:0070268 9.26 FLG IVL KRT10 KRT16
13 keratinocyte differentiation GO:0030216 8.92 FLG IVL KRT10 KRT16

Molecular functions related to Discoid Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.5 IFNA1 IFNA2 IL10
2 cytokine receptor binding GO:0005126 9.26 IFNA1 IFNA2
3 type I interferon receptor binding GO:0005132 9.16 IFNA1 IFNA2
4 structural constituent of epidermis GO:0030280 8.96 FLG KRT10
5 structural molecule activity GO:0005198 8.92 FLG IVL KRT10 KRT16

Sources for Discoid Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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