MCID: DSC009
MIFTS: 44

Discoid Lupus Erythematosus

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Discoid Lupus Erythematosus

MalaCards integrated aliases for Discoid Lupus Erythematosus:

Name: Discoid Lupus Erythematosus 60
Lupus Erythematosus, Discoid 74
Lupus Erythematosus Discoid 56

Characteristics:

Orphanet epidemiological data:

60
discoid lupus erythematosus
Prevalence: 1-9/100000 (United States);

Classifications:

Orphanet: 60  
Rare skin diseases


External Ids:

ICD10 34 L93.0
MESH via Orphanet 46 D008179
ICD10 via Orphanet 35 L93.0
UMLS via Orphanet 75 C0024138
Orphanet 60 ORPHA90281
UMLS 74 C0024138

Summaries for Discoid Lupus Erythematosus

MalaCards based summary : Discoid Lupus Erythematosus, also known as lupus erythematosus, discoid, is related to lichen sclerosus and keratosis, and has symptoms including pruritus, exanthema and heliotrope rash. An important gene associated with Discoid Lupus Erythematosus is IFNA2 (Interferon Alpha 2), and among its related pathways/superpathways are Allograft rejection and Keratinization. Affiliated tissues include skin, lung and t cells.

Wikipedia : 77 Discoid lupus erythematosus is the most common type of chronic cutaneous lupus (CCLE), an autoimmune... more...

Related Diseases for Discoid Lupus Erythematosus

Diseases related to Discoid Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
# Related Disease Score Top Affiliating Genes
1 lichen sclerosus 30.7 GZMB HLA-DRB1
2 keratosis 30.4 FLG IVL KRT10
3 lichen planus 30.4 FLG GZMB IVL KRT10 KRT16
4 contact dermatitis 30.3 FLG IL10 IVL KRT16
5 keratoacanthoma 30.3 FLG GZMB KRT10 KRT16
6 connective tissue disease 30.2 APOH HLA-DRB1 IL10
7 polyarteritis nodosa 30.2 APOH IFNA2
8 mixed connective tissue disease 30.0 APOH HLA-DRB1 IL10
9 allergic contact dermatitis 30.0 FLG IL10 NAT2
10 discoid lupus erythematosus of eyelid 12.5
11 lupus erythematosus 11.8
12 pseudopelade of brocq 11.5
13 squamous cell carcinoma 10.8
14 systemic lupus erythematosus 10.7
15 alopecia 10.6
16 dermatitis 10.5
17 chronic granulomatous disease 10.5
18 cutaneous lupus erythematosus 10.4
19 scleroderma, familial progressive 10.4
20 granulomatous disease, chronic, x-linked 10.4
21 porphyria 10.4
22 dermatitis herpetiformis, familial 10.3
23 panniculitis 10.3
24 dermatitis herpetiformis 10.3
25 bullous pemphigoid 10.3
26 blepharitis 10.3
27 lupus erythematosus tumidus 10.3
28 juvenile myasthenia gravis 10.3 HLA-DRB1 IL10
29 papillon-lefevre syndrome 10.3 GZMB HLA-DRB1
30 lichen disease 10.3 FLG IVL
31 rheumatoid arthritis 10.3
32 arthritis 10.3
33 calcinosis 10.3
34 psoriasis 10.3
35 dermatophytosis 10.3
36 lichen planopilaris 10.3
37 cystic echinococcosis 10.3 HLA-DRB1 IL10
38 acute disseminated encephalomyelitis 10.3 HLA-DRB1 IL10
39 orofacial granulomatosis 10.3 FLG IL10
40 filamentary keratitis 10.2 FLG KRT10
41 panuveitis 10.2 HLA-DRB1 IL10
42 porphyria cutanea tarda 10.2
43 complement component 2 deficiency 10.2
44 antiphospholipid syndrome 10.2
45 adenocarcinoma 10.2
46 localized scleroderma 10.2
47 herpes zoster 10.2
48 pemphigus 10.2
49 degos 'en cocarde' erythrokeratoderma 10.2
50 frontal fibrosing alopecia 10.2

Graphical network of the top 20 diseases related to Discoid Lupus Erythematosus:



Diseases related to Discoid Lupus Erythematosus

Symptoms & Phenotypes for Discoid Lupus Erythematosus

UMLS symptoms related to Discoid Lupus Erythematosus:


pruritus, exanthema, heliotrope rash, lupus-like rash

Drugs & Therapeutics for Discoid Lupus Erythematosus

Search Clinical Trials , NIH Clinical Center for Discoid Lupus Erythematosus

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Discoid Lupus Erythematosus

Anatomical Context for Discoid Lupus Erythematosus

MalaCards organs/tissues related to Discoid Lupus Erythematosus:

42
Skin, Lung, T Cells, Testes, Thyroid, B Cells, Liver

Publications for Discoid Lupus Erythematosus

Articles related to Discoid Lupus Erythematosus:

(show top 50) (show all 730)
# Title Authors Year
1
Lichen Planus Pigmentosus and Frontal Fibrosing Alopecia Mimicking Discoid Lupus Erythematosus. ( 30427589 )
2019
2
Intravenous immunoglobulin G use in patients with chronic inflammatory demyelinating polyneuropathy: An uncommon cause of drug-induced discoid lupus erythematosus. ( 30734274 )
2019
3
Pulsed-dye laser as an adjuvant treatment for discoid lupus erythematosus: a randomized, controlled trial. ( 29676592 )
2019
4
A rare case with prominent features of both discoid lupus erythematosus and pemphigus foliaceus. ( 29858874 )
2019
5
Chronic Inflammation Promotes Skin Carcinogenesis in Cancer-Prone Discoid Lupus Erythematosus. ( 30030152 )
2019
6
Coexistence of Tumid Lupus Erythematosus and Discoid Lupus Erythematosus. ( 30072022 )
2019
7
Discoid lupus erythematosus: Reflectance confocal microscopy features correlate with horizontal histopathological sections. ( 30357933 )
2019
8
Koebner phenomenon of discoid lupus erythematosus on old tattoos. ( 30486728 )
2019
9
Practice-Based Differences in Pediatric Discoid Lupus Erythematosus. ( 30768778 )
2019
10
Perforation of paper with pen: Simple technique to explain the carpet tack sign in discoid lupus erythematosus. ( 30905795 )
2019
11
Hearing loss caused by discoid lupus erythematosus of the ear canal successfully treated with hydroxychloroquine. ( 30932231 )
2019
12
S-1 induced discoid lupus erythematosus-like lesions and long-term complete response for para-aortic lymph node recurrence of pancreatic ductal adenocarcinoma: a case report. ( 29882080 )
2018
13
Frontal Fibrosing Alopecia and Discoid Lupus Erythematosus: More Than a Coincidence. ( 30482575 )
2018
14
JAK-STAT signaling pathway inhibition: a role for treatment of discoid lupus erythematosus and dermatomyositis. ( 29873082 )
2018
15
Eruptive Keratoacanthoma-Like Discoid Lupus Erythematosus. ( 28816744 )
2018
16
Multiple primary squamous cell carcinomas of the lower lip and tongue arising in discoid lupus erythematosus: a case report. ( 28967499 )
2018
17
Computerized planimetry to assess clinical responsiveness in a phase II randomized trial of topical R333 for discoid lupus erythematosus. ( 29336019 )
2018
18
X-linked TLR7 gene polymorphisms are associated with diverse immunological conditions but not with discoid lupus erythematosus in Polish patients. ( 29599669 )
2018
19
Verrucous Disseminated Discoid Lupus Erythematosus with Plantar and Oral Lesions in the Absence of Systemic Lupus Erthyematosus. ( 29644204 )
2018
20
A case report of lupus erythematosus tumidus converted from discoid lupus erythematosus. ( 29668590 )
2018
21
Clinical and dermoscopic spectrum of discoid lupus erythematosus: novel observations from lips and oral mucosa. ( 29700807 )
2018
22
Is chloroquine neuromyotoxicity in a patient with refractory discoid lupus erythematosus potentiated by concomitant use of mepacrine? ( 29808483 )
2018
23
Intravenous Immunoglobulins as a new opportunity to treat discoid lupus erythematosus: A case report and review of the literature. ( 29885539 )
2018
24
Discoid lupus erythematosus following herpes zoster. ( 29894527 )
2018
25
Mepacrine-induced interstitial lung disease in discoid lupus erythematosus? ( 30022483 )
2018
26
Unilateral Discoid Lupus Erythematosus Over the Face: An Unusual Presentation. ( 30050819 )
2018
27
Rapamycin for refractory discoid lupus erythematosus. ( 30109759 )
2018
28
A comparative immunohistochemical study of epidermal and dermal/perifollicular Langerhans cell concentration in discoid lupus erythematosus and lichen planopilaris: a cross-sectional study. ( 30376791 )
2018
29
Reply to: Direct Immunofluorescence Findings in Discoid Lupus Erythematosus and Bullous Pemphigoid. ( 28323786 )
2017
30
Direct Immunofluorescence Findings in Discoid Lupus Erythematosus and Bullous Pemphigoid. ( 26981743 )
2017
31
Linear cutaneous lupus erythematosus/discoid lupus erythematosus in an adult. ( 28507499 )
2017
32
Discoid lupus erythematosus in a patient with myasthenia gravis. ( 25963850 )
2017
33
Early discoid lupus erythematosus protects against renal disease in patients with systemic lupus erythematosus: longitudinal data from a large Latin American cohort. ( 27230554 )
2017
34
The relationship between disease severity and quality of life in discoid lupus erythematosus. ( 27943235 )
2017
35
Changes in T cell and B cell composition in discoid lupus erythematosus skin at different stages. ( 27964878 )
2017
36
Discoid lupus erythematosus occurring in an area previously affected by herpes zoster virus: Wolf's isotopic reaction? ( 27976613 )
2017
37
Brief Report: Pharmacodynamics, Safety, and Clinical Efficacy of AMG 811, a Human Anti-Interferon-γ Antibody, in Patients With Discoid Lupus Erythematosus. ( 28118537 )
2017
38
High Prevalence of Metabolic Syndrome in Patients with Discoid Lupus Erythematosus: A Cross-Sectional, Case-Control Study. ( 28127570 )
2017
39
A retrospective study comparing histopathological and immunopathological features of nasal planum dermatitis in 20 dogs with discoid lupus erythematosus or leishmaniosis. ( 28133824 )
2017
40
Verrucous discoid lupus erythematosus in a child. ( 28194816 )
2017
41
Successful treatment of recalcitrant discoid lupus erythematosus with ustekinumab. ( 28329473 )
2017
42
Bilateral malar milia en plaque as primary presentation of discoid lupus erythematosus. ( 28337470 )
2017
43
Drugs for discoid lupus erythematosus. ( 28476075 )
2017
44
Classifying discoid lupus erythematosus: background, gaps, and difficulties. ( 28492042 )
2017
45
Intense Pulsed Light and Q-Switched 1,064-nm Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment for the Scarring Lesion of Discoid Lupus Erythematosus. ( 28566911 )
2017
46
Development of classification criteria for discoid lupus erythematosus: Results of a Delphi exercise. ( 28606712 )
2017
47
Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome. ( 28626188 )
2017
48
Diagnostic value of immunohistochemistry staining of Bcl-2, CD34, CD20 and CD3 for distinction between discoid lupus erythematosus and lichen planus in the skin. ( 28631630 )
2017
49
Generalized Discoid Lupus Erythematosus as the Presenting Sign of Small Cell Lung Carcinoma. ( 28705287 )
2017
50
Disseminated discoid lupus erythematosus with a linear lesion on the forearm and hand: A rare presentation and review of literature. ( 28707650 )
2017

Variations for Discoid Lupus Erythematosus

Expression for Discoid Lupus Erythematosus

Search GEO for disease gene expression data for Discoid Lupus Erythematosus.

Pathways for Discoid Lupus Erythematosus

GO Terms for Discoid Lupus Erythematosus

Cellular components related to Discoid Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 APOH ENO3 IFNA1 IFNA2 IL10 KRT10
2 intermediate filament GO:0005882 9.13 FLG KRT10 KRT16
3 cornified envelope GO:0001533 8.8 FLG IVL KRT10

Biological processes related to Discoid Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.69 IVL KRT10 KRT16
2 aging GO:0007568 9.65 ENO3 IL10 KRT16
3 response to exogenous dsRNA GO:0043330 9.52 IFNA1 IFNA2
4 B cell differentiation GO:0030183 9.5 IFNA1 IFNA2 IL10
5 negative regulation of interferon-gamma production GO:0032689 9.49 HLA-DRB1 IL10
6 T cell activation involved in immune response GO:0002286 9.46 IFNA1 IFNA2
7 establishment of skin barrier GO:0061436 9.43 FLG KRT16
8 peptide cross-linking GO:0018149 9.43 FLG IVL KRT10
9 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.4 IFNA1 IFNA2
10 natural killer cell activation involved in immune response GO:0002323 9.37 IFNA1 IFNA2
11 B cell proliferation GO:0042100 9.33 IFNA1 IFNA2 IL10
12 cornification GO:0070268 9.26 FLG IVL KRT10 KRT16
13 keratinocyte differentiation GO:0030216 8.92 FLG IVL KRT10 KRT16

Molecular functions related to Discoid Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.5 IFNA1 IFNA2 IL10
2 cytokine receptor binding GO:0005126 9.26 IFNA1 IFNA2
3 type I interferon receptor binding GO:0005132 9.16 IFNA1 IFNA2
4 structural constituent of epidermis GO:0030280 8.96 FLG KRT10
5 structural molecule activity GO:0005198 8.92 FLG IVL KRT10 KRT16

Sources for Discoid Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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