MCID: DSC009
MIFTS: 47

Discoid Lupus Erythematosus

Categories: Skin diseases, Rare diseases

Aliases & Classifications for Discoid Lupus Erythematosus

MalaCards integrated aliases for Discoid Lupus Erythematosus:

Name: Discoid Lupus Erythematosus 59
Lupus Erythematosus, Discoid 73
Lupus Erythematosus Discoid 55

Characteristics:

Orphanet epidemiological data:

59
discoid lupus erythematosus
Prevalence: 1-9/100000 (United States);

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Orphanet 59 ORPHA90281
MESH via Orphanet 45 D008179
UMLS via Orphanet 74 C0024138
ICD10 via Orphanet 34 L93.0
ICD10 33 L93.0
UMLS 73 C0024138

Summaries for Discoid Lupus Erythematosus

MalaCards based summary : Discoid Lupus Erythematosus, also known as lupus erythematosus, discoid, is related to contact dermatitis and lichen sclerosus, and has symptoms including exanthema, pruritus and lupus-like rash. An important gene associated with Discoid Lupus Erythematosus is IFNA2 (Interferon Alpha 2), and among its related pathways/superpathways are Allograft rejection and Keratinization. The drugs Hydroxychloroquine and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and b cells.

Wikipedia : 76 Discoid lupus erythematosus (DLE) is a chronic skin condition of sores with inflammation and scarring... more...

Related Diseases for Discoid Lupus Erythematosus

Diseases related to Discoid Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 contact dermatitis 30.6 FLG IL10 KRT16
2 lichen sclerosus 30.3 GZMB HLA-DRB1
3 allergic contact dermatitis 30.2 FLG IL10 NAT2
4 polyarteritis nodosa 30.1 APOH IFNA2
5 keratosis 30.1 FLG IVL KRT10
6 connective tissue disease 29.9 APOH HLA-DRB1 IL10
7 syphilis 29.8 APOH HLA-DRB1
8 keratoacanthoma 29.6 FLG GZMB KRT10 KRT16
9 lichen planus 29.3 FLG GZMB IVL KRT10 KRT16
10 psoriasis 29.2 FLG IL10 IVL KRT10 KRT16
11 discoid lupus erythematosus of eyelid 12.3
12 systemic lupus erythematosus 11.7
13 lupus erythematosus 11.6
14 pseudopelade of brocq 11.3
15 recurrent respiratory papillomatosis 10.6 HLA-DRB1 IFNA2
16 squamous cell carcinoma 10.6
17 juvenile myasthenia gravis 10.6 HLA-DRB1 IL10
18 microscopic polyangiitis 10.6 HLA-DRB1 IL10
19 acute disseminated encephalomyelitis 10.5 HLA-DRB1 IL10
20 irritant dermatitis 10.5 FLG KRT16
21 orofacial granulomatosis 10.5 FLG IL10
22 cystic echinococcosis 10.5 HLA-DRB1 IL10
23 hemorrhagic fever 10.4 HLA-DRB1 IL10
24 squamous papillomatosis 10.4 IFNA1 IFNA2
25 alopecia 10.4
26 retinal artery occlusion 10.4 APOH IL10
27 dermatitis 10.4
28 steatocystoma multiplex 10.4 KRT10 KRT16
29 cryoglobulinemia, familial mixed 10.4 IFNA1 IFNA2
30 bowen's disease 10.4 KRT10 KRT16
31 panuveitis 10.4 HLA-DRB1 IL10
32 chronic granulomatous disease 10.4
33 squamous cell carcinoma of the oral tongue 10.3 KRT10 KRT16
34 transverse myelitis 10.3 APOH IL10
35 papillon-lefevre syndrome 10.3 GZMB HLA-DRB1
36 epstein-barr virus-associated gastric carcinoma 10.3 FLG IL10
37 chronic neutrophilic leukemia 10.3 IFNA1 IFNA2
38 filamentary keratitis 10.3 FLG KRT10
39 pulmonary tuberculosis 10.3 HLA-DRB1 IL10 NAT2
40 cutaneous lupus erythematosus 10.3
41 dermatitis, atopic 10.2 FLG IL10 IVL
42 ichthyosis, x-linked 10.2 FLG KRT10
43 peanut allergy 10.2 FLG HLA-DRB1 IL10
44 panniculitis 10.2
45 blepharitis 10.2
46 dermatitis herpetiformis, familial 10.2
47 dermatitis herpetiformis 10.2
48 bullous pemphigoid 10.2
49 scleroderma, familial progressive 10.2
50 porphyria 10.2

Graphical network of the top 20 diseases related to Discoid Lupus Erythematosus:



Diseases related to Discoid Lupus Erythematosus

Symptoms & Phenotypes for Discoid Lupus Erythematosus

UMLS symptoms related to Discoid Lupus Erythematosus:


exanthema, pruritus, lupus-like rash, heliotrope rash

Drugs & Therapeutics for Discoid Lupus Erythematosus

Drugs for Discoid Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxychloroquine Approved Phase 3 118-42-3 3652
2 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Not Applicable
3 Anti-Infective Agents Phase 3,Phase 2
4 Antiparasitic Agents Phase 3
5 Antiprotozoal Agents Phase 3
6 Antimalarials Phase 3
7
Etanercept Approved, Investigational Phase 2 185243-69-0
8
Apremilast Approved, Investigational Phase 1, Phase 2 608141-41-9 11561674
9
Alitretinoin Approved, Investigational Phase 2 5300-03-8 444795 449171
10
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
11 Analgesics Phase 2,Phase 1,Not Applicable
12 Gastrointestinal Agents Phase 2
13 Analgesics, Non-Narcotic Phase 2,Phase 1,Not Applicable
14 Peripheral Nervous System Agents Phase 2,Phase 1,Not Applicable
15 Antibodies Phase 1, Phase 2
16 Immunoglobulins Phase 1, Phase 2
17 Antibodies, Monoclonal Phase 1, Phase 2
18 Immunosuppressive Agents Phase 2,Not Applicable
19 Anti-Inflammatory Agents Phase 2,Phase 1,Not Applicable
20 Anti-Inflammatory Agents, Non-Steroidal Phase 2,Phase 1,Not Applicable
21 Dermatologic Agents Phase 2,Not Applicable
22 Angiogenesis Inhibitors Phase 2
23 Angiogenesis Modulating Agents Phase 2
24 Anti-Bacterial Agents Phase 2
25 Phosphodiesterase 4 Inhibitors Phase 1, Phase 2
26 Phosphodiesterase 5 Inhibitors Phase 1, Phase 2
27 Phosphodiesterase Inhibitors Phase 1, Phase 2
28 Keratolytic Agents Phase 2
29 tyrosine Nutraceutical Phase 1
30
Tacrolimus Approved, Investigational Not Applicable 104987-11-3 445643 439492
31
Betamethasone Approved, Vet_approved Not Applicable 378-44-9 9782
32
Pimecrolimus Approved, Investigational Not Applicable 137071-32-0 6447131 17753757
33
belimumab Approved 356547-88-1 5957 10451420
34
Tofacitinib Approved, Investigational Early Phase 1 477600-75-2
35
Citric Acid Approved, Nutraceutical, Vet_approved Early Phase 1 77-92-9 311
36 Betamethasone Valerate Not Applicable 2152-44-5
37 glucocorticoids Not Applicable
38 Respiratory System Agents Not Applicable
39 Complement System Proteins
40 Hormone Antagonists Not Applicable
41 Hormones Not Applicable
42 Hormones, Hormone Substitutes, and Hormone Antagonists Not Applicable
43 Anti-Asthmatic Agents Not Applicable
44 Betamethasone benzoate Not Applicable
45 Betamethasone sodium phosphate Not Applicable
46 Betamethasone-17,21-dipropionate Not Applicable
47 Calcineurin Inhibitors Not Applicable
48 Chelating Agents Early Phase 1
49 Anticoagulants Early Phase 1
50 Protein Kinase Inhibitors Early Phase 1

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 Efficacy of 595 nm Pulsed-dye Laser in Treatment of Discoid Lupus Erythematosus Recruiting NCT03178188 Phase 2, Phase 3
2 Hydroxychloroquine (HCQ) for Recurrent Pregnancy Loss Recruiting NCT03305263 Phase 3 Hydroxychloroquine;Hydroxychloroquine placebo
3 The Safety and Efficacy of Etanercept (Enbrel®) for the Treatment of Discoid Lupus Erythematosus Unknown status NCT00797784 Phase 2 etanercept(Enbrel®)
4 Phase Ib Study of SC Milatuzumab in SLE Unknown status NCT01845740 Phase 1, Phase 2 milatuzumab;Placebo
5 Efficacy and Safety of ASF-1096 Cream 0.5% in the Treatment of Discoid Lupus Erythematosus (DLE) Lesions Completed NCT00625521 Phase 2 ASF 1096 0.5 % cream applied twice daily;Cream vehicle for ASF 1096 cream applied twice daily
6 Efficacy and Safety of ASF-1096 Cream 0.5% in the Treatment of Discoid Lupus Erythematosus (DLE) Lesions (2) Completed NCT00625157 Phase 2 ASF 1096 0.5 % cream;ASF 1096 placebo cream
7 A Pilot Trial of Topical Thalidomide for the Management of Chronic Discoid Lupus Erythematosus Completed NCT00001680 Phase 2 Thalidomide
8 Safety and Efficacy of Topical R333 in Patients With Discoid Lupus Erythematosus (DLE) and Systemic Lupus Erythematosus (SLE) Lesions Completed NCT01597050 Phase 2 R932333;Placebo
9 Safety Study of Clinical and Immune Effects of Phosphodiesterase 4 (PDE-4) Inhibitor in Cutaneous Lupus Patients Completed NCT00708916 Phase 1, Phase 2 CC-10004
10 To Evaluate the Preliminary Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of CC-11050 in Subjects With Discoid Lupus Erythematosus and Subacute Cutaneous Lupus Erythematosus Completed NCT01300208 Phase 2 CC-11050
11 Study to Evaluate BIIB059 in Cutaneous Lupus Erythematosus (CLE) With or Without Systemic Lupus Erythematosus (SLE) Recruiting NCT02847598 Phase 2 BIIB059;Placebo
12 Targeted Therapy Using Intradermal Injection of Etanercept for Remission Induction in Discoid Lupus Erythematosus Active, not recruiting NCT02656082 Phase 2 Etanercept
13 Discoid Lupus Erythematosus of the Scalp and a Trial of Biologic Therapy With Raptiva Terminated NCT00308204 Phase 2 Raptiva (efalizumab)
14 A Research Study to Assess if CC-930 is Safe in Treating Subjects With Discoid Lupus Erythematosus Terminated NCT01466725 Phase 2 CC-930;Placebo
15 Efficacy and Safety of Oral Alitretinoin (Toctino®) in the Treatment of Patients With Cutaneous Lupus Erythematosus Terminated NCT01407679 Phase 2 Alitretinoin
16 Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Clinical Effect of GSK2646264 in Cutaneous Lupus Erythematosus Patients Active, not recruiting NCT02927457 Phase 1 GSK2646264 1%;Placebo
17 Autologous Polyclonal Tregs for Lupus Active, not recruiting NCT02428309 Phase 1
18 Safety Study of AMG 811 in Subjects With Discoid Lupus Erythematosus Terminated NCT01164917 Phase 1 AMG811;AMG811 Placebo
19 Comparing the Therapeutic Efficacy of Pimecrolimus Cream With Betamethasone Cream for Discoid Lupus Erythematosus Completed NCT00608673 Not Applicable Pimecrolimus 1% cream;betamethasone valerate 0.1% cream
20 Pilot Tape Harvesting Study Completed NCT02125695
21 Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia Completed NCT00691769
22 A Non-drug Study Profiling Cutaneous Lupus Completed NCT01923415
23 A Study of Skin and Systemic Biomarkers In Patients With Active Cutaneous Lupus Erythematosus And In Healthy Volunteers Completed NCT02034344
24 A Pooled Analysis of the HGS1006-C1056 (BLISS-52) and HGS1006-C1057 (BLISS-76) Studies Completed NCT01858792 Belimumab 1 mg/kg;Belimumab 10 mg/kg
25 Oral Tofacitinib in Adult Subjects With Discoid Lupus Erythematosus (DLE) and Systemic Lupus Erythematosus (SLE) Recruiting NCT03159936 Early Phase 1
26 Trichoscopy in Diagnosis of Immunobollous Diseases Not yet recruiting NCT03478072
27 Cutaneous Lupus Erythematosus and Elidel Withdrawn NCT00222183 Not Applicable Elidel (pimecrolimus)

Search NIH Clinical Center for Discoid Lupus Erythematosus

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Discoid Lupus Erythematosus

Anatomical Context for Discoid Lupus Erythematosus

MalaCards organs/tissues related to Discoid Lupus Erythematosus:

41
Skin, T Cells, B Cells, Testes, Lung, Liver, Tongue

Publications for Discoid Lupus Erythematosus

Articles related to Discoid Lupus Erythematosus:

(show top 50) (show all 585)
# Title Authors Year
1
Computerized planimetry to assess clinical responsiveness in a phase II randomized trial of topical R333 for discoid lupus erythematosus. ( 29336019 )
2018
2
X-linked TLR7 gene polymorphisms are associated with diverse immunological conditions but not with discoid lupus erythematosus in Polish patients. ( 29599669 )
2018
3
Discoid lupus erythematosus following herpes zoster. ( 29894527 )
2018
4
Verrucous Disseminated Discoid Lupus Erythematosus with Plantar and Oral Lesions in the Absence of Systemic Lupus Erthyematosus. ( 29644204 )
2018
5
Pulsed-dye laser as an adjuvant treatment for discoid lupus erythematosus: a randomized, controlled trial. ( 29676592 )
2018
6
A case report of lupus erythematosus tumidus converted from discoid lupus erythematosus. ( 29668590 )
2018
7
JAK-STAT signaling pathway inhibition: a role for treatment of discoid lupus erythematosus and dermatomyositis. ( 29873082 )
2018
8
A rare case with prominent features of both discoid lupus erythematosus and pemphigus foliaceus. ( 29858874 )
2018
9
Multiple primary squamous cell carcinomas of the lower lip and tongue arising in discoid lupus erythematosus: a case report. ( 28967499 )
2018
10
Is chloroquine neuromyotoxicity in a patient with refractory discoid lupus erythematosus potentiated by concomitant use of mepacrine? ( 29808483 )
2018
11
S-1 induced discoid lupus erythematosus-like lesions and long-term complete response for para-aortic lymph node recurrence of pancreatic ductal adenocarcinoma: a case report. ( 29882080 )
2018
12
Intravenous Immunoglobulins as a new opportunity to treat discoid lupus erythematosus: A case report and review of the literature. ( 29885539 )
2018
13
Clinical and dermoscopic spectrum of discoid lupus erythematosus: novel observations from lips and oral mucosa. ( 29700807 )
2018
14
Rare cause of periorbital and eyelids lesions: Discoid lupus erythematosus misdiagnosed as allergy. ( 29102423 )
2017
15
Bilateral malar milia en plaque as primary presentation of discoid lupus erythematosus. ( 28337470 )
2017
16
Verrucous discoid lupus erythematosus in a child. ( 28194816 )
2017
17
Diagnostic value of immunohistochemistry staining of Bcl-2, CD34, CD20 and CD3 for distinction between discoid lupus erythematosus and lichen planus in the skin. ( 28631630 )
2017
18
White rosettes in discoid lupus erythematosus: a new dermoscopic observation. ( 29214102 )
2017
19
Incidental Focal Acantholytic Dyskeratosis in a Patient with Discoid Lupus Erythematosus: A Possible Role for SPCA1 in the Pathogenesis of the Disease. ( 28966534 )
2017
20
Blue-White Veil as Novel Dermatoscopic Feature in Discoid Lupus Erythematosus in 2 African-American Patients. ( 29177151 )
2017
21
Eruptive Keratoacanthoma-Like Discoid Lupus Erythematosus. ( 28816744 )
2017
22
Discoid Lupus Erythematosus Presenting as Upper Eyelid Edema and Erythema. ( 28918619 )
2017
23
Classifying discoid lupus erythematosus: background, gaps, and difficulties. ( 28492042 )
2017
24
Intense Pulsed Light and Q-Switched 1,064-nm Neodymium-Doped Yttrium Aluminum Garnet Laser Treatment for the Scarring Lesion of Discoid Lupus Erythematosus. ( 28566911 )
2017
25
High Prevalence of Metabolic Syndrome in Patients with Discoid Lupus Erythematosus: A Cross-Sectional, Case-Control Study. ( 28127570 )
2017
26
Discoid lupus erythematosus: when a superficial injury is a red herring of underlying disease. ( 29038195 )
2017
27
Successful treatment of recalcitrant discoid lupus erythematosus with ustekinumab. ( 28329473 )
2017
28
A Rare Case of Lupus Vulgaris with Papulonecrotic Tuberculid and Discoid Lupus Erythematosus. ( 28836565 )
2017
29
Discoid Lupus Erythematosus Complicated with Pregnancy-induced Hemophagocytic Syndrome. ( 28626188 )
2017
30
Drugs for discoid lupus erythematosus. ( 28476075 )
2017
31
Development of classification criteria for discoid lupus erythematosus: Results of a Delphi exercise. ( 28606712 )
2017
32
Brief Report: Pharmacodynamics, Safety, and Clinical Efficacy of AMG 811, a Human Anti-Interferon-I^ Antibody, in Patients With Discoid Lupus Erythematosus. ( 28118537 )
2017
33
A rare case of unilateral discoid lupus erythematosus mimicking lupus vulgaris. ( 29122902 )
2017
34
Linear cutaneous lupus erythematosus/discoid lupus erythematosus in an adult. ( 28507499 )
2017
35
Reply to: Direct Immunofluorescence Findings in Discoid Lupus Erythematosus and Bullous Pemphigoid. ( 28323786 )
2017
36
Disseminated discoid lupus erythematosus with a linear lesion on the forearm and hand: A rare presentation and review of literature. ( 28707650 )
2017
37
Generalized Discoid Lupus Erythematosus as the Presenting Sign of Small Cell Lung Carcinoma. ( 28705287 )
2017
38
A retrospective study comparing histopathological and immunopathological features of nasal planum dermatitis in 20 dogs with discoid lupus erythematosus or leishmaniosis. ( 28133824 )
2017
39
Familial discoid lupus erythematosus evolving to systemic lupus erythematosus with lung involvement after more than a decade in older adults. ( 28960709 )
2017
40
Antiphospholipid syndrome with subsequent chronic discoid lupus erythematosus: a case report. ( 27068596 )
2016
41
Direct Immunofluorescence Findings in Discoid Lupus Erythematosus and Bullous Pemphigoid. ( 26981743 )
2016
42
Early discoid lupus erythematosus protects against renal disease in patients with systemic lupus erythematosus: longitudinal data from a large Latin American cohort. ( 27230554 )
2016
43
Microarray study reveals a TGFI^-Dependent mechanism of fibrosis in discoid lupus erythematosus. ( 26972571 )
2016
44
Mutilating Squamous Cell Carcinoma: A Rare Complication of an Early Plaque of Discoid Lupus Erythematosus. ( 27617504 )
2016
45
Clinical and microscopic features of generalized discoid lupus erythematosus in dogs (10 cases). ( 27747960 )
2016
46
Indicators for Differentiating Atypical Discoid Lupus Erythematosus from Epifolliculitis with Dermoscopy. ( 27174341 )
2016
47
Podoplanin Expression Is Correlated With the Progression of Chronic Discoid Lupus Erythematosus to Lip Squamous Cell Carcinoma. ( 27240861 )
2016
48
The Relationship Between Disease Severity in Discoid Lupus Erythematosus and Quality of Life. ( 27943235 )
2016
49
Squamous cell carcinoma on the lip arising from discoid lupus erythematosus: a case report and review of Japanese patients. ( 27046922 )
2016
50
Changes in T cell and B cell composition in discoid lupus erythematosus skin at different stages. ( 27964878 )
2016

Variations for Discoid Lupus Erythematosus

Expression for Discoid Lupus Erythematosus

Search GEO for disease gene expression data for Discoid Lupus Erythematosus.

Pathways for Discoid Lupus Erythematosus

GO Terms for Discoid Lupus Erythematosus

Cellular components related to Discoid Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 APOH ENO3 IFNA1 IFNA2 IL10 KRT10
2 intermediate filament GO:0005882 9.13 FLG KRT10 KRT16
3 cornified envelope GO:0001533 8.8 FLG IVL KRT10

Biological processes related to Discoid Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.7 IVL KRT10 KRT16
2 aging GO:0007568 9.65 ENO3 IL10 KRT16
3 response to exogenous dsRNA GO:0043330 9.54 IFNA1 IFNA2
4 regulation of type I interferon-mediated signaling pathway GO:0060338 9.51 IFNA1 IFNA2
5 B cell differentiation GO:0030183 9.5 IFNA1 IFNA2 IL10
6 negative regulation of interferon-gamma production GO:0032689 9.49 HLA-DRB1 IL10
7 T cell activation involved in immune response GO:0002286 9.46 IFNA1 IFNA2
8 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.43 IFNA1 IFNA2
9 peptide cross-linking GO:0018149 9.43 FLG IVL KRT10
10 establishment of skin barrier GO:0061436 9.4 FLG KRT16
11 natural killer cell activation involved in immune response GO:0002323 9.37 IFNA1 IFNA2
12 B cell proliferation GO:0042100 9.33 IFNA1 IFNA2 IL10
13 cornification GO:0070268 9.26 FLG IVL KRT10 KRT16
14 keratinocyte differentiation GO:0030216 8.92 FLG IVL KRT10 KRT16

Molecular functions related to Discoid Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.5 IFNA1 IFNA2 IL10
2 cytokine receptor binding GO:0005126 9.26 IFNA1 IFNA2
3 type I interferon receptor binding GO:0005132 9.16 IFNA1 IFNA2
4 structural constituent of epidermis GO:0030280 8.96 FLG KRT10
5 structural molecule activity GO:0005198 8.92 FLG IVL KRT10 KRT16

Sources for Discoid Lupus Erythematosus

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69 SNOMED-CT via HPO
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74 UMLS via Orphanet
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