MCID: DSC013
MIFTS: 23

Discrimination, Two-Point, Reduction in

Aliases & Classifications for Discrimination, Two-Point, Reduction in

MalaCards integrated aliases for Discrimination, Two-Point, Reduction in:

Name: Discrimination, Two-Point, Reduction in 56
Sensory Discrimination 56

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
discrimination, two-point, reduction in:
Inheritance autosomal dominant inheritance


External Ids:

OMIM 56 126180
MedGen 41 C1852074
SNOMED-CT via HPO 68 263681008 88425004

Summaries for Discrimination, Two-Point, Reduction in

MalaCards based summary : Discrimination, Two-Point, Reduction in, also known as sensory discrimination, is related to back pain and dystonia. The drugs Fluorodeoxyglucose F18 and Dextroamphetamine have been mentioned in the context of this disorder. Affiliated tissues include cortex, brain and testes, and related phenotype is abnormality of the nervous system.

More information from OMIM: 126180

Related Diseases for Discrimination, Two-Point, Reduction in

Diseases related to Discrimination, Two-Point, Reduction in via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)
# Related Disease Score Top Affiliating Genes
1 back pain 10.1
2 dystonia 10.0
3 autism 9.9
4 focal hand dystonia 9.9
5 dysphagia 9.9
6 swallowing disorders 9.9
7 hair whorl 9.7
8 huntington disease 9.7
9 attention deficit-hyperactivity disorder 9.7
10 syringomyelia, noncommunicating isolated 9.7
11 stroke, ischemic 9.7
12 anxiety 9.7
13 focal dystonia 9.7
14 spasmodic dystonia 9.7
15 cerebral palsy 9.7
16 syringomyelia 9.7
17 peripheral nervous system disease 9.7
18 neuropathy 9.7
19 trichorhinophalangeal syndrome 9.7
20 spasmodic dysphonia 9.7
21 chronic pain 9.7
22 benign idiopathic neonatal seizures 9.7

Graphical network of the top 20 diseases related to Discrimination, Two-Point, Reduction in:



Diseases related to Discrimination, Two-Point, Reduction in

Symptoms & Phenotypes for Discrimination, Two-Point, Reduction in

Human phenotypes related to Discrimination, Two-Point, Reduction in:

31
# Description HPO Frequency HPO Source Accession
1 abnormality of the nervous system 31 HP:0000707

Symptoms via clinical synopsis from OMIM:

56
Neuro:
reduced two-point discrimination

Clinical features from OMIM:

126180

Drugs & Therapeutics for Discrimination, Two-Point, Reduction in

Drugs for Discrimination, Two-Point, Reduction in (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fluorodeoxyglucose F18 Phase 4
2
Dextroamphetamine Approved, Illicit Phase 2 51-64-9 5826
3
Amphetamine Approved, Illicit, Investigational Phase 2 300-62-9 5826 3007
4
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
5 Excitatory Amino Acid Antagonists Phase 2
6 Central Nervous System Stimulants Phase 2
7 Catechol Phase 2
8 Adrenergic Agents Phase 2
9 Antiparkinson Agents Phase 2
10 Neurotransmitter Agents Phase 2
11 Sympathomimetics Phase 2
12 Dopamine Agents Phase 2
13
Oxymetazoline Approved, Investigational 1491-59-4 4636

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective Single Arm Pilot Study to Investigate the Dynamic Brain and Multifidus Muscle Imaging in Response to Multifidus Stimulation in Patients With Low Back Pain Undergoing Reactiv8 Implant Not yet recruiting NCT04327817 Phase 4
2 Pharmacologic Augmentation of Neurocognition and Cognitive Training in Psychosis Recruiting NCT02634684 Phase 2 Dextroamphetamine;Placebo
3 A Follow-up Comparison of Sensory Discrimination in Patients With Low Back Pain: a Randomized Control Trial Completed NCT03760887
4 A Randomized Controlled Trial of Manual Therapy as a Form of Sensory Discrimination in Chronic Low Back Pain Completed NCT02757378
5 Accelerating Motor Learning in Pediatrics Completed NCT03193580
6 The Effects of Lower Extremity Sensory Retraining Treatment in Individuals With Post-stroke Sensory Impairment Completed NCT01988220
7 Behavioral and Brain Connectivity Analysis of Upper Limb Sensorimotor Rehabilitation Post Stroke: a Randomized Controlled Trial Completed NCT03236376
8 The Relationship Between Temporal Discrimination and Cortical Excitability in Humans Completed NCT00726050
9 Early Physiotherapy, Mandibular Motion and Sensorial Recovery After Orthognathic Surgery Recruiting NCT03465033
10 Investigation of Human Laryngeal Evoked Brainstem Potentials Active, not recruiting NCT02803359

Search NIH Clinical Center for Discrimination, Two-Point, Reduction in

Genetic Tests for Discrimination, Two-Point, Reduction in

Anatomical Context for Discrimination, Two-Point, Reduction in

MalaCards organs/tissues related to Discrimination, Two-Point, Reduction in:

40
Cortex, Brain, Testes, Cerebellum, Prefrontal Cortex, Thalamus, Olfactory Bulb

Publications for Discrimination, Two-Point, Reduction in

Articles related to Discrimination, Two-Point, Reduction in:

(show top 50) (show all 437)
# Title Authors PMID Year
1
Essential role for neuronal nitric oxide synthase in acute ethanol-induced motor impairment. 61
32278831 2020
2
Attention control: The missing link between sensory discrimination and intelligence. 61
32514663 2020
3
Neuroscience: From Sensory Discrimination to Choice in Gustatory Cortex. 61
32428476 2020
4
Sensory discrimination between aversive salty and bitter tastes in an haematophagous insect. 61
32048391 2020
5
Spoilage Potential of Pseudomonas (P. fragi, P. putida) and LAB (Leuconostoc mesenteroides, Lactobacillus sakei) Strains and Their Volatilome Profile During Storage of Sterile Pork Meat Using GC/MS and Data Analytics. 61
32423080 2020
6
A combined DTI and resting state functional MRI study in patients with postherpetic neuralgia. 61
32067145 2020
7
Normal Temporal Discrimination in Musician's Dystonia Is Linked to Aberrant Sensorimotor Processing. 61
31930574 2020
8
Effects of modified-release fampridine on upper limb impairment in patients with Multiple Sclerosis. 61
32062444 2020
9
Fundamental bounds on the fidelity of sensory cortical coding. 61
32238928 2020
10
Suboptimal learning of tactile-spatial predictions in patients with complex regional pain syndrome. 61
31651574 2020
11
Neurotized Free Tissue Transfer for Foot Reconstruction: A Systematic Review. 61
31450252 2020
12
Distributed representations of temporal stimulus associations across regular-firing and fast-spiking neurons in rat medial prefrontal cortex. 61
31851558 2020
13
A Brain to Spine Interface for Transferring Artificial Sensory Information. 61
31964948 2020
14
Alcohol and nicotine co-Administration during pregnancy and lactation periods alters sensory discrimination of adult NMRI mice offspring. 61
31682889 2020
15
Applied cognitive strategy behaviours in people with parkinson's disease during daily activities: A cross-sectional study. 61
31820814 2019
16
Predictive value of laryngeal adductor reflex testing in patients with dysphagia due to a cerebral vascular accident. 61
30301381 2019
17
Fine-Grained Mapping of Cortical Somatotopies in Chronic Complex Regional Pain Syndrome. 61
31570533 2019
18
Weber's Law: A Mechanistic Foundation after Two Centuries. 61
31629634 2019
19
Mismatch negativity reveals plasticity in cortical dynamics after 1-hour of auditory training exercises. 61
31176741 2019
20
Childhood leukemia survivors exhibit deficiencies in sensory and cognitive processes, as reflected by event-related brain potentials after completion of curative chemotherapy: A preliminary investigation. 61
31156064 2019
21
Creating a neuroprosthesis for active tactile exploration of textures. 61
31591224 2019
22
Sensory characterization and acceptance of coffee brews of C. arabica and C. canephora blended with steamed defective coffee. 61
31466646 2019
23
Response to "Fallacies of Mice Experiments". 61
31377994 2019
24
Somatosensory Discrimination in People With Autism Spectrum Disorder: A Scoping Review. 61
31484025 2019
25
Brain moderators supporting the relationship between depressive mood and pain. 61
31095097 2019
26
Prefrontal Cortex Regulates Sensory Filtering through a Basal Ganglia-to-Thalamus Pathway. 61
31202541 2019
27
Tablet-based sensorimotor home-training system for amnestic mild cognitive impairments in the elderly: design of a randomised clinical trial. 61
31377702 2019
28
Best Evidence Rehabilitation for Chronic Pain Part 3: Low Back Pain. 61
31331087 2019
29
Continuous 2D control via state-machine triggered by endogenous sensory discrimination and a fast brain switch. 61
31075785 2019
30
Awake Mouse Imaging: From Two-Photon Microscopy to Blood Oxygen Level-Dependent Functional Magnetic Resonance Imaging. 61
30691968 2019
31
Deficits in auditory sensory discrimination among children with attention-deficit/hyperactivity disorder. 61
30229307 2019
32
Mechanisms of Sensory Discrimination: Insights from Drosophila Olfaction. 61
30786228 2019
33
Using sensory discrimination in a foraging-style task to evaluate human upper-limb sensorimotor performance. 61
30967581 2019
34
STarT Back Tool risk stratification is associated with changes in movement profile and sensory discrimination in low back pain: A study of 290 patients. 61
30582876 2019
35
Visuospatial working memory, auditory discrimination, and attention. 61
30306828 2019
36
Modulation of fear generalization by the zona incerta. 61
30967506 2019
37
Heterogeneity of cough neurobiology: Clinical implications. 61
30763726 2019
38
Initial Studies of Validity of the Sensory Processing 3-Dimensions Scale. 61
29465281 2019
39
Timing Is of the Essence: Improvement in Perception During Active Sensing. 61
31143104 2019
40
Minocycline Prevents the Development of Mechanical Allodynia in Mouse Models of Vincristine-Induced Peripheral Neuropathy. 61
31316337 2019
41
Does Sensory Retraining Improve Sensation and Sensorimotor Function Following Stroke: A Systematic Review and Meta-Analysis. 61
31114472 2019
42
Efficient inference for time-varying behavior during learning. 61
31244514 2018
43
A cortico-cerebellar loop for motor planning. 61
30333626 2018
44
Somatosensory and auditory deviance detection for outcome prediction during postanoxic coma. 61
30250859 2018
45
Brain motor functional changes after somatosensory discrimination training. 61
28861843 2018
46
Measuring dexterity in the podiatrist population: a cross-sectional comparison of novice students and experienced podiatrists. 61
30071848 2018
47
Sensory dissociation in chronic low back pain: Two case reports. 61
29324082 2018
48
Home-Based Tactile Discrimination Training Reduces Phantom Limb Pain. 61
29105971 2018
49
Postnatal Ablation of Synaptic Retinoic Acid Signaling Impairs Cortical Information Processing and Sensory Discrimination in Mice. 61
29760176 2018
50
Alterations in post-movement beta event related synchronization throughout the migraine cycle: A controlled, longitudinal study. 61
28478712 2018

Variations for Discrimination, Two-Point, Reduction in

Expression for Discrimination, Two-Point, Reduction in

Search GEO for disease gene expression data for Discrimination, Two-Point, Reduction in.

Pathways for Discrimination, Two-Point, Reduction in

GO Terms for Discrimination, Two-Point, Reduction in

Sources for Discrimination, Two-Point, Reduction in

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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