Disease of Mental Health disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: DSS008 MIFTS: 53	Disease of Mental Health Categories: Mental diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Disease of Mental Health

MalaCards integrated aliases for Disease of Mental Health:

Name: Disease of Mental Health ¹¹ ¹⁴

Mental Health ⁴¹ ¹⁶ ⁷⁵

Mental Disorders ⁴³ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Mental diseases Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³¹

Mental and behavioural disorders

Organic, including symptomatic, mental disorders

Other mental disorders due to brain damage and dysfunction and to physical disease

Other specified mental disorders due to brain damage and dysfunction and to physical disease

Unspecified mental disorder due to brain damage and dysfunction and to physical disease

Unspecified mental disorder

Mental disorder, not otherwise specified

External Ids:

Disease Ontology ¹¹ DOID:150

MeSH ⁴³ D001523

NCIt ⁴⁹ C2893

SNOMED-CT ⁶⁸ 74732009

ICD10 ³¹ F06.8 F06.9 F99 more

EFO ¹⁶ EFO_0003935

UMLS ⁷¹ C0004936

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Summaries for Disease of Mental Health

MedlinePlus: ⁴¹ What is mental health? Mental health includes our emotional, psychological, and social well-being. It affects how we think, feel, and act as we cope with life. It also helps determine how we handle stress, relate to others, and make choices. Mental health is important at every stage of life, from childhood and adolescence through adulthood and aging. What are mental disorders? Mental disorders are serious conditions which can affect your thinking, mood, and behavior. They may be occasional or long-lasting. They can affect your ability to relate to others and function each day. Mental disorders are common; more than half of all Americans will be diagnosed with one at some time in their life. But there are treatments. People with mental disorders can get better, and many of them recover completely. Why is mental health important? Mental health is important because it can help you to: Cope with the stresses of life Be physically healthy Have good relationships Make meaningful contributions to your community Work productively Realize your full potential Your mental health is also important because it can affect your physical health. For example, mental disorders can raise your risk for physical health problems such as stroke, type 2 diabetes, and heart disease. What can affect my mental health? There are many different factors that can affect your mental health, including: Biological factors, such as genes or brain chemistry Life experiences, such as trauma or abuse Family history of mental health problems Your lifestyle, such as diet, physical activity, and substance use You can also affect your mental health by taking steps to improve it, such as doing meditation, using relaxation techniques, and practicing gratitude. Can my mental health change over time? Over time, your mental health can change. For example, you may be dealing with a difficult situation, such as trying to manage a chronic illness, taking care of an ill relative, or facing money problems. The situation may wear you out and overwhelm your ability to cope with it. This can worsen your mental health. On the other hand, getting therapy may improve your mental health. What are the signs that I might have a mental health problem? When it comes to your emotions, it can be hard to know what is normal and what is not. There are warning signs that you may have a mental health problem, including: A change in your eating or sleeping habits Withdrawing from the people and activities you enjoy Having low or no energy Feeling numb or like nothing matters Having unexplained aches and pains Feeling helpless or hopeless Smoking, drinking, or using drugs more than usual Feeling unusually confused, forgetful, angry, upset, worried, or scared Having severe mood swings that cause problems in your relationships Having thoughts and memories that you can't get out of your head Hearing voices or believing things that are not true Thinking of harming yourself or others Not being able to perform daily tasks like taking care of your kids or getting to work or school What should I do if I think I have a mental health problem? If you think that you may have a mental health problem, get help. Talk therapy and/or medicines can treat mental disorders. If you don't know where to start, contact your primary care provider.

MalaCards based summary: Disease of Mental Health, also known as mental health, is related to post-traumatic stress disorder and bipolar disorder, and has symptoms including lethargy, agitation and forgetful. An important gene associated with Disease of Mental Health is BDNF-AS (BDNF Antisense RNA). The drugs Acetaminophen and Donepezil have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and prefrontal cortex.

Disease Ontology: ¹¹ A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture.

Wikipedia: ⁷⁵ Mental health encompasses emotional, psychological, and social well-being, influencing cognition,... more...

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Related Diseases for Disease of Mental Health

Diseases related to Disease of Mental Health via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1555)

#	Related Disease	Score	Top Affiliating Genes
1	post-traumatic stress disorder	33.3	MIR124-1 H2AC18 BDNF
2	bipolar disorder	33.0	PRODH MIR132 KDM4C BDNF APOE
3	attention deficit-hyperactivity disorder	33.0	SERPINA3 PRODH MIR24-1 H2AC18 EPRS1 BDNF
4	substance abuse	32.9	SERPINA3 PRODH MIR9-1 H2AC18 CCR6 BDNF
5	psychotic disorder	32.7	SERPINA3 PRODH MIR9-1 MIR24-1 MIR22 MIR21
6	schizophrenia	32.7	SERPINA3 PRODH MIR9-1 MIR132 BLOC1S1 BDNF-AS
7	learning disability	32.7	PRODH MIR9-1 H2AC18 BDNF
8	mood disorder	32.6	SERPINA3 PRODH MIR9-1 MIR24-1 MIR132 MIR124-1
9	alcohol use disorder	32.6	SERPINA3 PRODH KDM4C H2AC18 CCR6 BDNF
10	pervasive developmental disorder	32.6	PRODH MIR9-1 MIR24-1 MIR132 KDM4C H2AC18
11	generalized anxiety disorder	32.5	PRODH H2AC18 BDNF
12	specific developmental disorder	32.5	SERPINA3 PRODH MIR9-1 MIR24-1 MIR21 MIR132
13	sleep disorder	32.5	H2AC18 BDNF APOE
14	dementia, lewy body	32.4	SERPINA3 MIR9-1 MIR22 MIR132 H2AC18 BDNF
15	schizoaffective disorder	32.4	SERPINA3 PRODH BDNF
16	social phobia	31.9	SERPINA3 PRODH BDNF
17	nutritional deficiency disease	31.9	SERPINA3 H2AC18 CCR6 BDNF
18	parkinson disease, late-onset	31.9	SERPINA3 PRODH MIR9-1 MIR24-1 MIR22 MIR21
19	body mass index quantitative trait locus 11	31.8	SERPINA3 PRODH MIR9-1 MIR22 MIR21 MIR142
20	multiple sclerosis	31.7	MIR21 MIR142 MIR132 CCR6 BDNF APOE
21	agoraphobia	31.7	PRODH MIR22 BDNF
22	cardiovascular system disease	31.7	SERPINA3 PRODH MIR9-1 MIR24-1 MIR22 MIR21
23	immune deficiency disease	31.7	SERPINA3 MIR9-1 MIR24-1 MIR22 MIR21 MIR142
24	heart disease	31.6	SERPINA3 PRODH MIR24-1 MIR21 MIR142 H2AC18
25	phobia, specific	31.6	PRODH H2AC18 BDNF
26	chronic fatigue syndrome	31.6	SERPINA3 MIR142 H2AC18 CCR6 BDNF
27	gastrointestinal system disease	31.6	SERPINA3 MIR9-1 MIR24-1 MIR22 MIR21 MIR142
28	substance dependence	31.6	SERPINA3 H2AC18 BDNF
29	mild cognitive impairment	31.6	SERPINA3 MIR22 MIR142 MIR132 BDNF APOE
30	alzheimer disease, familial, 1	31.6	SERPINA3 PRODH MIR9-1 MIR24-1 MIR22 MIR21
31	pulmonary disease, chronic obstructive	31.6	SERPINA3 MIR21 MIR142 H2AC18 CCR6
32	dermatitis, atopic	31.5	SERPINA3 MIR21 MIR142 CCR6 BDNF
33	speech and communication disorders	31.5	SERPINA3 PRODH BDNF APOE
34	skin disease	31.5	SERPINA3 PRODH MIR9-1 MIR24-1 MIR21 MIR142
35	respiratory failure	31.5	SERPINA3 MIR21 MIR142 H2AC18 CCR6
36	physical disorder	31.5	SERPINA3 PRODH MIR9-1 MIR24-1 MIR21 MIR142
37	cerebrovascular disease	31.5	SERPINA3 MIR9-1 MIR22 MIR21 MIR142 MIR132
38	fetal alcohol syndrome	31.4	MIR9-1 KDM4C H2AC18 BDNF
39	lung disease	31.4	SERPINA3 MIR21 MIR142 H2AC18 EPRS1 CCR6
40	migraine with or without aura 1	31.4	SERPINA3 H2AC18 BDNF APOE
41	type 2 diabetes mellitus	31.4	SERPINA3 PRODH MIR9-1 MIR22 MIR21 MIR142
42	severe covid-19	31.3	SERPINA3 MIR21 CCR6
43	lipid metabolism disorder	31.3	SERPINA3 MIR21 H2AC18 CCR6 APOE
44	huntington disease	31.3	SERPINA3 PRODH MIR9-1 MIR24-1 MIR22 MIR132
45	subjective cognitive decline	31.3	SERPINA3 BDNF APOE
46	amyotrophic lateral sclerosis 1	31.3	SERPINA3 PRODH MIR9-1 MIR24-1 MIR22 MIR142
47	arteriosclerosis	31.3	MIR24-1 MIR22 MIR21 MIR142 APOE
48	arteries, anomalies of	31.3	SERPINA3 MIR9-1 MIR24-1 MIR22 MIR21 MIR142
49	eye disease	31.2	SERPINA3 PRODH MIR9-1 MIR22 MIR21 MIR142
50	lipoprotein quantitative trait locus	31.2	SERPINA3 MIR24-1 MIR22 MIR21 MIR142 MIR132

Graphical network of the top 20 diseases related to Disease of Mental Health:

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Symptoms & Phenotypes for Disease of Mental Health

UMLS symptoms related to Disease of Mental Health:

lethargy; agitation; forgetful; decrease in appetite; nervousness; feeling jittery; symptoms; alexithymia; increased libido; numbness; psychiatric symptom; hallucinations, auditory; hallucinations, visual; numbness localized; feeling detached; feeling strange; feeling weightless; floating feeling; dejection emotional; depressed reaction; hallucinations, sensory; restless sleep; difficulty sleeping; excitability; depression aggravated; agitation mental; numb mouth; opiate withdrawal symptoms; clouded consciousness; trembling inside; sluggishness

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Drugs & Therapeutics for Disease of Mental Health

Drugs for Disease of Mental Health (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 430)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Acetaminophen

Approved

Phase 4

103-90-2

1983

Donepezil

Approved

Phase 4

120014-06-4

3152

Naltrexone

Approved, Investigational, Vet_approved

Phase 4

16590-41-3

5360515

Modafinil

Approved, Investigational

Phase 4

68693-11-8

4236

Metamfetamine

Approved, Illicit, Withdrawn

Phase 4

537-46-2

10836

Fluvoxamine

Approved, Investigational

Phase 4

54739-18-3

5324346 3404

Amitriptyline

Approved

Phase 4

50-48-6

2160

Norepinephrine

Approved

Phase 4

51-41-2

439260

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1, 1867-66-9

3821

Duloxetine

Approved

Phase 4

136434-34-9, 116539-59-4

60835

Histamine

Approved, Investigational

Phase 4

51-45-6

774

Mirtazapine

Approved

Phase 4

85650-52-8, 61337-67-5

4205

Paroxetine

Approved, Investigational

Phase 4

61869-08-7

43815

Lamotrigine

Approved, Investigational

Phase 4

84057-84-1

3878

Cyproheptadine

Approved

Phase 4

129-03-3

2913

Methylphenidate

Approved, Investigational

Phase 4

113-45-1

4158

Cinnarizine

Approved, Investigational

Phase 4

298-57-7

1547484

Diazepam

Approved, Illicit, Investigational, Vet_approved

Phase 4

439-14-5

3016

Metformin

Approved

Phase 4

1115-70-4, 657-24-9

4091

Perphenazine

Approved

Phase 4

58-39-9

4748

Clonazepam

Approved, Illicit

Phase 4

1622-61-3

2802

Simvastatin

Approved

Phase 4

79902-63-9

54454

Ferrous succinate

Approved

Phase 4

10030-90-7

Sibutramine

Approved, Illicit, Investigational, Withdrawn

Phase 4

106650-56-0

5210

Acetylcysteine

Approved, Investigational

Phase 4

616-91-1

581 12035

Propofol

Approved, Investigational, Vet_approved

Phase 4

2078-54-8

4943

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Sodium oxybate

Approved

Phase 4

502-85-2

23663870

Losartan

Approved

Phase 4

114798-26-4

3961

Angiotensin II

Approved, Investigational

Phase 4

68521-88-0, 11128-99-7, 4474-91-3

172198

Progesterone

Approved, Vet_approved

Phase 4

57-83-0

5994

Guanfacine

Approved, Investigational

Phase 4

29110-47-2

3519

Bupropion

Approved

Phase 4

31677-93-7, 34841-39-9, 34911-55-2

444

Dexmedetomidine

Approved, Experimental, Vet_approved

Phase 4

86347-14-0, 113775-47-6

68602 5311068

gamma-Aminobutyric acid

Approved, Investigational

Phase 4

56-12-2

119

Exenatide

Approved, Investigational

Phase 4

141758-74-9

45588096

Estradiol

Approved, Investigational, Vet_approved

Phase 4

50-28-2

5757

Polyestradiol phosphate

Approved

Phase 4

28014-46-2

Tocopherol

Approved, Investigational

Phase 4

1406-66-2

Coconut

Approved

Phase 4

Iodine

Approved, Investigational

Phase 4

7553-56-2

807

Glucagon

Approved

Phase 4

16941-32-5

16133228 16186314

Liraglutide

Approved

Phase 4

204656-20-2

44147092 16134956

Ethanol

Approved

Phase 4

64-17-5

702

Trazodone

Approved, Investigational

Phase 4

19794-93-5

5533

Sertraline

Approved

Phase 4

79617-96-2

68617

Citalopram

Approved

Phase 4

59729-32-7, 59729-33-8

2771

Galantamine

Approved

Phase 4

357-70-0, 1953-04-4

9651

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Interventional clinical trials:

(show top 50) (show all 3064)

#	Name	Status	NCT ID	Phase	Drugs
1	Clinical Psychopharmacology Division Institute of Mental Health, Peking University	Unknown status	NCT03148535	Phase 4	Lithium Carbonate;lithium carbonate combined with SSRI antidepressant treatment
2	Clinical Psychopharmacology Division Institute of Mental Health, Peking University	Unknown status	NCT03148509	Phase 4	risperidone;aripiprazole;bupropion
3	Comparison of Paracetamol and Dexketoprofen Trometamol on Headache Treatment After Electroconvulsive Treatment	Unknown status	NCT03830398	Phase 4	Paracetamol;Deksketoprofen trometamol;Placebo
4	Determination of ED50 and ED95 of Single Bolus Dexmedetomidine in General Anesthesia Patients to Produce Acceptable Hemodynamic Outcomes	Unknown status	NCT03655847	Phase 4	Dexmedetomidine
5	Clozapine Versus Olanzapine as Treatment for Comorbid Psychotic Disorder and Substance Use Disorder	Unknown status	NCT03857581	Phase 4	Clozapine;Olanzapine
6	Open Flexible-dose Randomized Study of the Effectiveness of Second Generation Antipsychotics in First Episode Psychosis Patients: A 3-year Follow-up	Unknown status	NCT03090503	Phase 4	Aripiprazole;Risperidone
7	Clinical Utility of Pharmacogenomics of Psychotropic Medications	Unknown status	NCT03907124	Phase 4	Genetically-guided treatment with FDA-approved psychotropic drugs;Treatment as usual (TAU)
8	Neurocognitive Effectiveness in Treatment of First-episode Non-affective Psychosis: a Randomized Comparison of Aripiprazole and Risperidone Over 3 Years	Unknown status	NCT03883204	Phase 4	Aripiprazole;Risperidone
9	Determining the Efficacy and Tolerance of Quetiapine Extended Release (XR) for the Management of Psychotic Aggression or Agitation in Adult Acute Psychiatry	Unknown status	NCT00986167	Phase 4	Quetiapine XR
10	Open Flexible-dose Randomized Study of the Effectiveness of Second Generation Antipsychotics in First Episode Psychosis Patients: A 1-year Follow-up	Unknown status	NCT02532491	Phase 4	Aripiprazole;Risperidone
11	Tolerance and Effect of Antipsychotics in Children and Adolescents With Psychosis- An Investigator-initiated, Phase IV, Randomised Double-blind Multi-centre Trial of the Benefits and Harms of Aripiprazole Versus Quetiapine in Children and Adolescents With Psychosis	Unknown status	NCT01119014	Phase 4	Aripiprazole;Quetiapine
12	Effect of Slow-release Melatonin (Circadin®) Therapy on Idiopathic REM Sleep Behavior Disorder: a Pilot Study	Unknown status	NCT02836743	Phase 4	Circadin;Placebo
13	Reduction of Cardiovascular Risk in Severe Mental Illness Prescribing and Using Better and More Appropriated Drugs	Unknown status	NCT01182012	Phase 4
14	The Impact of Cholinesterase Inhibitors on Driving Ability in Healthy Older Adults: A Pilot Study	Completed	NCT00482001	Phase 4	donepezil;Placebo (cornstarch)
15	Study on the Effect of Combined Oral Contraceptive Therapy on Female Sexuality, Body Image and Mental Health	Completed	NCT02613039	Phase 4	Combined Estrogen-Progestin Oral Contraceptives
16	A DOUBLE-BLIND PILOT STUDY TO EVALUATE THE SAFETY AND EFFICACY OF PROVIGIL® (MODAFINIL) AT FIXED/FLEXIBLE DOSES, IN CONJUNCTION WITH IDENTIFIED SSRIs FOR THE TREATMENT OF EXCESSIVE SLEEPINESS IN PATIENTS WITH MILD TO MODERATE DEPRESSION WITH ATTENDANT SYMPTOMS OF SLEEPINESS AND FATIGUE	Completed	NCT00208715	Phase 4	Provigil
17	The Role of Vitamin D Supplementation on Well Being and Symptoms of Depression During the Winter Season in Health Service Staff	Completed	NCT01462058	Phase 4	Placebo
18	Memory and Mental Health in Aging: Psychopharmacological Augmentation of Memory Training in Older Adults	Completed	NCT02988908	Phase 4	Donepezil;Placebos
19	Retrospective Review of Ketamine Assisted Psychotherapy Program on Mental Health at Field Trip Health Centres in North America	Completed	NCT05604794	Phase 4
20	Joining Forces: Integrating Psychotropic Medication Into the Care of People With Mental Disorders in a Prayer Camp in Ghana	Completed	NCT02593734	Phase 4	olanzapine;risperidone;amitryptaline;fluoxetine
21	Brain Imaging and Mental Disorders of Aging Intervention	Completed	NCT00267163	Phase 4	donepezil;Placebo
22	Efficacy of Exposure and Response Prevention（ERP） and SSRIs, and Its Predictors in Obsessive-Compulsive Disorder	Completed	NCT02022709	Phase 4	Fluoxetine;Sertraline;Paroxetine;Citalopram;Fluvoxamine
23	A Double-Blind Placebo-Controlled Study of Combination Therapy in Children With ADHD	Completed	NCT01940978	Phase 4	Methylphenidate ER;Cyproheptadine
24	Naltrexone Treatment of Alcohol Abuse in Schizophrenia	Completed	NCT00145847	Phase 4	Naltrexone or Placebo
25	Post-marketing Clinical Study on PAXIL Tablet in Patients With Depression or Depressive Mood - A Study on Combination of PAXIL Tablet and Benzodiazepines	Completed	NCT00259883	Phase 4	paroxetine
26	Receptor Occupancy Determined by PET Neuroimaging of [11C]Mirtazapine in Healthy Humans	Completed	NCT00288782	Phase 4	Mirtazapine
27	Preparing Those With Significant and Persistent Mental Illness to Quit Smoking	Completed	NCT01783912	Phase 4	Nicotine Patch
28	Therapeutic Effect Between Quetiapine and Haloperidol on the Treatment of Methamphetamine - Induced Psychosis	Completed	NCT01939093	Phase 4	Diazepam;Stugeron
29	A 16-Week Open-Label Study of the Effects of Treatment With Pimavanserin on Activities of Daily Living in Subjects With Parkinson's Disease Psychosis	Completed	NCT04292223	Phase 4	Pimavanserin
30	Improving Metabolic Parameters of Antipsychotic Child Treatment (IMPACT)	Completed	NCT00806234	Phase 4	Aripiprazole or Perphenazine;Metformin;Olanzapine, quetiapine, risperidone, ziprasidone, aripiprazole, asenapine, iloperidone, lurasidone, paliperidone, or olanzapine/fluoxetine
31	An Open, Multicenter, Non-Comparative Study To Assess The Efficacy And Tolerability Of Intramuscular Ziprasidone Followed By Oral Ziprasidone In Patients With Acute Psychosis	Completed	NCT00644800	Phase 4	Ziprasidone
32	Efficacy and Safety of Risperidone Oral Solution Combination Clonazepam Versus Haloperidol IM Injection for Treatment of Acute Psychotic Agitation in Schizophrenia	Completed	NCT00859872	Phase 4	risperidone oral solution;haloperidol
33	A Single-arm Evaluation of the Safety of Paliperidone Extended-Release (ER) in Subjects With Schizophrenia or Schizoaffective Disorder With Hepatic Disease	Completed	NCT00535145	Phase 4	Treatment as usual (TAU), Paliperidone ER
34	A Phase IV STudy of the Effectiveness of Quetiapine Extended Release 600mg Once a Day to Control the Symptoms of Manic Phase of Bipolar Disorder.	Completed	NCT00521365	Phase 4	Quetiapine 600mg
35	Randomized, Controlled Study of Iron Supplementation of Infants With Birth Weights 2000-2500 g	Completed	NCT00558454	Phase 4	Iron
36	Indicated Prevention With Omega-3 Fatty Acids in Adolescents With 'At-Risk-Mental-State' for Psychosis: A Randomised, Double Blind, Placebo-Controlled Treatment Trial	Completed	NCT00396643	Phase 4	Omega 3 fatty acids
37	Phase IV Study of the Effectiveness of Aripiprazole, Quetiapine, and Ziprasidone in the Treatment of First Episode of Non-affective Psychosis Individuals Included in the First Episode Psychosis Clinical Program II (PAFIP II)	Completed	NCT02305823	Phase 4	Aripiprazole;Quetiapine;Ziprasidone
38	Cannabis and Schizophrenia: Effects of Clozapine	Completed	NCT00498550	Phase 4	Clozapine;Treatment as usual
39	Injectable Versus Oral Naltrexone Treatment of Alcohol Dependence In Serious Mental Illness (SMI): A Pilot Study	Completed	NCT00453804	Phase 4	injectable naltrexone;oral naltrexone
40	Injectable Naltrexone Treatment of Alcohol Dependence in Serious Mental Illness (SMI): An Open Prospective Pilot Trial	Completed	NCT00453609	Phase 4	long-lasting injectable naltrexone
41	Antipsychotic Discontinuation in Alzheimer's Disease	Completed	NCT00417482	Phase 4	risperidone
42	Is Premorbid Functioning a Predictor of Outcome in Patients With Early Onset Psychosis Treated With Risperdal Consta?	Completed	NCT00369239	Phase 4	risperidone long acting injectable
43	Single-arm, Open-label and Multicenter Phase IV Study: Efficacy and Safety of Quetiapine in Treating Affective Symptoms of Patients With First-episode Psychosis - a Pilot Study	Completed	NCT00511277	Phase 4	Seroquel®
44	The Cognitive Effects of Risperidone and Olanzapine	Completed	NCT00108368	Phase 4	Risperidone;Olanzapine
45	The Assessment of a Anti-Obesity Agent for the Treatment of Olanzapine-Associated Weight Gain in Patients With Schizophrenia, Schizophreniform Disorder, Schizoaffective Disorder and Bipolar I Disorder	Completed	NCT00044187	Phase 4	Sibutramine
46	Treatment of Agitation/Psychosis in Dementia/Parkinsonism (TAP/DAP)	Completed	NCT00043849	Phase 4	Quetiapine
47	Interventions for Cardiovascular Disease: "Real-World" Effectiveness of Combined Pharmacotherapy and Behavioural Counseling for Smoking Cessation	Completed	NCT01623505	Phase 4	Champix;Transdermal Nicoderm patch combined with gum or inhaler;Transdermal Nicoderm patch
48	A Multicentre, 8-week, Single-arm, Open-label, Pragmatic Trial to Explore Acceptance and Performance of Using a Digital Medicine System With Healthcare Professionals and Adult Subjects With Schizophrenia, Schizoaffective Disorder, or First Episode Psychosis on an Oral Atypical Antipsychotic (Aripiprazole, Olanzapine, Quetiapine, or Risperidone)	Completed	NCT03568500	Phase 4	Aripiprazole;Olanzapine;Quetiapine;Risperidone
49	Pimozide Augmentation of Clozapine in Schizophrenia	Completed	NCT00158223	Phase 4	Pimozide;Placebo
50	Efficacy of Quetiapine in Treating Patients With Active Substance Use Disorder and Schizophrenia	Completed	NCT00156715	Phase 4	Quetiapine

Search NIH Clinical Center for Disease of Mental Health

Cochrane evidence based reviews: mental disorders

Sources

Genetic Tests for Disease of Mental Health

Sources

Anatomical Context for Disease of Mental Health

Organs/tissues related to Disease of Mental Health:

MalaCards : Brain, Heart, Prefrontal Cortex, Pituitary, Eye, Spinal Cord, Breast

Sources

Publications for Disease of Mental Health

Articles related to Disease of Mental Health:

(show top 50) (show all 30003)

#	Title	Authors	PMID	Year
1	Mental Health Chatbot for Young Adults With Depressive Symptoms During the COVID-19 Pandemic: Single-Blind, Three-Arm Randomized Controlled Trial. ⁴¹	He Y...Tian T	36355633	2022
2	Mediators of measurement-based care implementation in community mental health settings: results from a mixed-methods evaluation. ⁴¹	Lewis CC...Albright K	36271404	2022
3	The Effect of Healthy Lifestyle Changes on Work Ability and Mental Health Symptoms: A Randomized Controlled Trial. ⁴¹	Shiri R...Borg P	36293787	2022
4	Childhood Abuse and Neglect, Exposure to Domestic Violence and Sibling Violence: Profiles and Associations With Sociodemographic Variables and Mental Health Indicators. ⁶²	Sharratt K...Wager NM	35445607	2023
5	Synaptic plasticity and mental health: methods, challenges and opportunities. ⁶²	Appelbaum LG...Daskalakis Z	35810199	2023
6	"Don't Just Study our Distress, Do Something": Implementing and Evaluating a Modified Stepped-Care Model for Health Care Worker Mental Health During the COVID-19 Pandemic. ⁶²	Sheehan KA...Berkhout SG	35854421	2023
7	The (un)learning of social functions and its significance for mental health. ⁶²	Flechsenhar A...Bertsch K	36216722	2022
8	Mental Health before and during the COVID-19 Pandemic: The Role of Partnership and Parenthood Status in Growing Disparities between Types of Families. ⁶²	Hiekel N...Kuhn M	35837870	2022
9	Competing against COVID-19: what about the mental health problems of athletes with disabilities? ⁶²	Denerel N...Lima Y	34961402	2022
10	Associations among Self-Reported Mental Health, Physical Activity, and Diet during the COVID-19 Pandemic. ⁶²	Andersen JA...McElfish PA	35234099	2022
11	Prevalence of parental mental health conditions among children aged 0-16 years in Denmark: A nationwide register-based cross-sectional study. ⁶²	Christesen AMS...Heuckendorff S	34609273	2022
12	Mental health consequences of COVID-19 pandemic among college students and coping approaches adapted by higher education institutions: A scoping review. ⁶²	Pandya A...Lodha P	35665095	2022
13	Measuring the quality of mental health services from the patient perspective in China: psychometric evaluation of the Chinese version of the World Health Organization responsiveness performance questionnaire. ⁶²	Zhou W...Liu X	35289731	2022
14	Insomnia and poor sleep quality during peripartum: a family issue with potential long term consequences on mental health. ⁶²	Baglioni C...Palagini L	33267621	2022
15	You're carrying so many people's stories: vicarious trauma among fly-in fly-out mental health service providers in Canada. ⁶²	Roberts C...van Bruggen R	35195506	2022
16	Acute relationships between mental health and cognitive function during the COVID-19 pandemic: Longitudinal evidence from middle-aged and older US adults. ⁶²	Kobayashi LC...Finlay JM	35434675	2022
17	Adolescent Mental Health and Family Economic Hardships: The Roles of Adverse Childhood Experiences and Family Conflict. ⁶²	Barnhart S...Karcher NR	35997913	2022
18	Daily stressors and mental health following disaster: A school-based assessment of adolescent disaster survivors in China and Nepal. ⁶²	Newnham EA...Leaning J	36067255	2022
19	Idioms of resilience: Mental health and migration in India. ⁶²	Raghavan R...Heblikar D	34461755	2022
20	Antibiotics and mental health: The good, the bad and the ugly. ⁶²	Dinan K...Dinan T	35819136	2022
21	Characteristics of the ideal healthcare services to meet adolescents' mental health needs: A qualitative study of adolescents' perspectives. ⁶²	Meldahl LG...Viksveen P	36074720	2022
22	Factors associated with prolonged episodes of mechanical restraint in mental health hospitalization units in Andalusia. ⁶²	Guzman-Parra J...Mayoral-Cleries F	35088924	2022
23	The impact of the COVID-19 pandemic on the mental health of women seeking treatment for postpartum depression. ⁶²	Chang O...Van Lieshout RJ	34882058	2022
24	How does the British public understand mental health? A qualitative analysis of open-text responses. ⁶²	Arnot M...Greenwood E	34694185	2022
25	Sex-related differences in violence exposure, neural reactivity to threat, and mental health. ⁶²	Dark HE...Knight DC	36030316	2022
26	Medical students' perception towards mental health recovery: a descriptive qualitative study. ⁶²	Kuek JHL...Goh YS	35894690	2022
27	Mental health symptoms 1 year after the COVID-19 outbreak in Spain: The role of pre-existing mental disorders and their type. ⁶²	Monistrol-Mula A...Haro JM	36058361	2022
28	Self-reported mental health symptoms, quality of life and coping strategies in French health sciences students during the early stage of the COVID-19 pandemic: An online survey. ⁶²	Leaune E...Poulet E	34625216	2022
29	Differential Impact of COVID-19 on the Use of Tele-mental Health Among Veterans Living in Urban or Rural Areas. ⁶²	Hogan J...Ecker AH	35652189	2022
30	Sleep quality of Singapore residents: findings from the 2016 Singapore mental health study. ⁶²	Lee YY...Subramaniam M	35243325	2022
31	Outdoor Community Ambulation Interventions to Improve Physical and Mental Health in Older Adults: A Systematic Review and Meta-Analysis. ⁶²	Bhatia D...Barclay R	35418512	2022
32	Practitioner and researcher perspectives on the utility of ecological momentary assessment in mental health care: A survey study. ⁶²	Piot M...Bos FM	36193339	2022
33	Association of Mental Health Burden With Prenatal Cannabis Exposure From Childhood to Early Adolescence: Longitudinal Findings From the Adolescent Brain Cognitive Development (ABCD) Study. ⁶²	Baranger DAA...Bogdan R	36094599	2022
34	Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses. ⁶²	Kalman JL...Papiol S	35146571	2022
35	A time for self-care? Frontline health workers' strategies for managing mental health during the COVID-19 pandemic. ⁶²	Lewis S...Smallwood N	34913042	2022
36	Associations Between Changes in Loneliness and Social Connections, and Mental Health During the COVID-19 Pandemic: The Women's Health Initiative. ⁶²	Goveas JS...Anderson GL	34915558	2022
37	Factors associated with work performance and mental health of healthcare workers during pandemics: a systematic review and meta-analysis. ⁶²	Nowrouzi-Kia B...Ott M	34056663	2022
38	Correction to: Families in the COVID‑19 pandemic: parental stress, parent mental health and the occurrence of adverse childhood experiences-results of a representative survey in Germany. ⁶²	Calvano C...Winter SM	34159498	2022
39	Australian Aboriginal and Torres Strait Islander people at risk of declining mental health due to failure to attend for referred follow-up mental health appointments during COVID-19. ⁶²	Usher K...Sibbritt D	36070004	2022
40	Should I write about mental health on my med school app? Examining medical school admissions committee members' biases regarding mental health conditions. ⁶²	Abraham AE...Cooper KM	35900355	2022
41	The role of self-compassion in the mental health of adults with ADHD. ⁶²	Beaton DM...Milne E	35334113	2022
42	Mental health problems and risk assessment in football players infected with SARS-CoV-2: a cross-sectional study. ⁶²	Lima Y...Rice S	35191288	2022
43	Mental health nursing and autism: I am a mental health nurse so why did it take me so long to realize I'm autistic? ⁶²	Sweetmore V	33866640	2022
44	Probable COVID-19 infection is associated with subsequent poorer mental health and greater loneliness in the UK COVID-19 Mental Health and Wellbeing study. ⁶²	Wilding S...O'Connor RC	36460665	2022
45	The mental health impact of COVID-19-related stressors among treatment-seeking trauma-exposed veterans. ⁶²	McLean CP...Cloitre M	36065487	2022
46	Association of sleep with mental health in Chinese high school students: a cross-sectional study. ⁶²	Xue B...Zhang C	35879019	2022
47	A nation-wide Swedish study of opioid analgesic prescribing patterns during pregnancy and associated preexisting mental health conditions. ⁶²	Sujan AC...D'Onofrio BM	33441038	2022
48	Food Insufficiency, Adverse Childhood Events and Mental Health: Results of the Singapore Mental Health Study 2016. ⁶²	Subramaniam M...Chong SA	36451283	2022
49	Self-reported fears and mental health in elementary school children across Europe. ⁶²	Husky MM...Kovess-Masfety V	34125282	2022
50	The Perfect Storm: A Developmental-Sociocultural Framework for the Role of Social Media in Adolescent Girls' Body Image Concerns and Mental Health. ⁶²	Choukas-Bradley S...Nesi J	35841501	2022

Sources

Genes for Disease of Mental Health

Genes related to Disease of Mental Health (0 elite genes):

(show top 50) (show all 122)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	BDNF-AS	BDNF Antisense RNA	RNA Gene	155.53	Experimental evidence: Expression ³⁷ DISEASES inferred ¹⁴	23831425
2	MCHR2-AS1	MCHR2 Antisense RNA 1	RNA Gene	152.9	Experimental evidence ³⁷ DISEASES inferred ¹⁴	26461262
3	SNRNP70	Small Nuclear Ribonucleoprotein U1 Subunit 70	Protein Coding	14.12	DISEASES inferred ¹⁴ GeneCards inferred via : Summaries (show sections)
4	PRODH	Proline Dehydrogenase 1	Protein Coding	13.84	DISEASES inferred ¹⁴ ¹⁴
5	H2AC18	H2A Clustered Histone 18	Protein Coding	13.09	DISEASES inferred ¹⁴ ¹⁴
6	SERPINA3	Serpin Family A Member 3	Protein Coding	12.94	DISEASES inferred ¹⁴ ¹⁴
7	MIR132	MicroRNA 132	RNA Gene	11.89	DISEASES inferred ¹⁴ ¹⁴
8	MIR9-1	MicroRNA 9-1	RNA Gene	11.45	DISEASES inferred ¹⁴ ¹⁴
9	EPRS1	Glutamyl-Prolyl-TRNA Synthetase 1	Protein Coding	10.98	DISEASES inferred ¹⁴ ¹⁴
10	MIR24-1	MicroRNA 24-1	RNA Gene	10.26	DISEASES inferred ¹⁴ ¹⁴
11	MIR124-1	MicroRNA 124-1	RNA Gene	10.2	DISEASES inferred ¹⁴ ¹⁴
12	ERCC6	ERCC Excision Repair 6, Chromatin Remodeling Factor	Protein Coding	10.16	DISEASES inferred ¹⁴ ¹⁴
13	MIR21	MicroRNA 21	RNA Gene	10.04	DISEASES inferred ¹⁴ ¹⁴
14	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	9.99	DISEASES inferred ¹⁴
15	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	9.94	DISEASES inferred ¹⁴ ¹⁴
16	KDM4C	Lysine Demethylase 4C	Protein Coding	9.94	DISEASES inferred ¹⁴ ¹⁴
17	APOE	Apolipoprotein E	Protein Coding	9.81	DISEASES inferred ¹⁴
18	BLOC1S1	Biogenesis Of Lysosomal Organelles Complex 1 Subunit 1	Protein Coding	9.78	DISEASES inferred ¹⁴ ¹⁴
19	MIR142	MicroRNA 142	RNA Gene	9.71	DISEASES inferred ¹⁴ ¹⁴
20	MIR22	MicroRNA 22	RNA Gene	9.69	DISEASES inferred ¹⁴ ¹⁴
21	APP	Amyloid Beta Precursor Protein	Protein Coding	9.61	DISEASES inferred ¹⁴
22	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	9.59	DISEASES inferred ¹⁴
23	MIRLET7D	MicroRNA Let-7d	RNA Gene	9.58	DISEASES inferred ¹⁴ ¹⁴
24	MAPT	Microtubule Associated Protein Tau	Protein Coding	9.49	DISEASES inferred ¹⁴
25	MIR212	MicroRNA 212	RNA Gene	9.38	DISEASES inferred ¹⁴ ¹⁴
26	OXT	Oxytocin/Neurophysin I Prepropeptide	Protein Coding	9.38	DISEASES inferred ¹⁴
27	SLC6A3	Solute Carrier Family 6 Member 3	Protein Coding	9.36	DISEASES inferred ¹⁴
28	MIR140	MicroRNA 140	RNA Gene	9.36	DISEASES inferred ¹⁴ ¹⁴
29	SNCA	Synuclein Alpha	Protein Coding	9.36	DISEASES inferred ¹⁴
30	FMR1	Fragile X Messenger Ribonucleoprotein 1	Protein Coding	9.35	DISEASES inferred ¹⁴
31	MIR126	MicroRNA 126	RNA Gene	9.32	DISEASES inferred ¹⁴ ¹⁴
32	DRD2	Dopamine Receptor D2	Protein Coding	9.32	DISEASES inferred ¹⁴
33	MECP2	Methyl-CpG Binding Protein 2	Protein Coding	9.31	DISEASES inferred ¹⁴
34	MIR15B	MicroRNA 15b	RNA Gene	9.3	DISEASES inferred ¹⁴ ¹⁴
35	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	9.3	DISEASES inferred ¹⁴
36	MIR128-1	MicroRNA 128-1	RNA Gene	9.26	DISEASES inferred ¹⁴ ¹⁴
37	MIRLET7B	MicroRNA Let-7b	RNA Gene	9.25	DISEASES inferred ¹⁴ ¹⁴
38	MIR29A	MicroRNA 29a	RNA Gene	9.22	DISEASES inferred ¹⁴ ¹⁴
39	MIR17	MicroRNA 17	RNA Gene	9.22	DISEASES inferred ¹⁴ ¹⁴
40	MIR155	MicroRNA 155	RNA Gene	9.2	DISEASES inferred ¹⁴ ¹⁴
41	COMT	Catechol-O-Methyltransferase	Protein Coding	9.19	DISEASES inferred ¹⁴
42	IL6	Interleukin 6	Protein Coding	9.16	DISEASES inferred ¹⁴
43	HTR2A	5-Hydroxytryptamine Receptor 2A	Protein Coding	9.16	DISEASES inferred ¹⁴
44	MIR144	MicroRNA 144	RNA Gene	9.14	DISEASES inferred ¹⁴ ¹⁴
45	MIR106B	MicroRNA 106b	RNA Gene	9.14	DISEASES inferred ¹⁴ ¹⁴
46	HCRT	Hypocretin Neuropeptide Precursor	Protein Coding	9.13	DISEASES inferred ¹⁴
47	MIR199A1	MicroRNA 199a-1	RNA Gene	9.12	DISEASES inferred ¹⁴ ¹⁴
48	MIR146A	MicroRNA 146a	RNA Gene	9.1	DISEASES inferred ¹⁴ ¹⁴
49	INS	Insulin	Protein Coding	9.1	DISEASES inferred ¹⁴
50	MIR223	MicroRNA 223	RNA Gene	9.09	DISEASES inferred ¹⁴ ¹⁴

Sources

Variations for Disease of Mental Health

Sources

Expression for Disease of Mental Health

Search GEO for disease gene expression data for Disease of Mental Health.

Sources

Pathways for Disease of Mental Health

Pathways directly related to Disease of Mental Health:

#	Pathway	Source
1	Defective MAOA causes BRUNS	Reactome ⁶⁶

Sources

GO Terms for Disease of Mental Health

Cellular components related to Disease of Mental Health according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	RISC complex	GO:0016442	9.47	MIR9-1 MIR24-1 MIR22 MIR21 MIR142 MIR132
2	extracellular vesicle	GO:1903561	9.35	MIR24-1 MIR22 MIR21 APOE

Biological processes related to Disease of Mental Health according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	miRNA-mediated gene silencing	GO:0035195	9.73	MIR9-1 MIR24-1 MIR22 MIR21 MIR142 MIR132
2	negative regulation of endothelial cell proliferation	GO:0001937	9.62	MIR22 MIR21 APOE
3	negative regulation of blood vessel endothelial cell migration	GO:0043537	9.46	MIR24-1 MIR132 APOE
4	negative regulation of NIK/NF-kappaB signaling	GO:1901223	9.43	MIR9-1 MIR21 MIR132
5	miRNA-mediated gene silencing by inhibition of translation	GO:0035278	8.92	MIR9-1 MIR24-1 MIR21 MIR132