MCID: DSP001
MIFTS: 21

Displacement of Cardia Through Esophageal Hiatus

Categories: Gastrointestinal diseases

Aliases & Classifications for Displacement of Cardia Through Esophageal Hiatus

MalaCards integrated aliases for Displacement of Cardia Through Esophageal Hiatus:

Name: Displacement of Cardia Through Esophageal Hiatus 12 15
Congenital Hiatus Hernia 12 32

Classifications:



External Ids:

Disease Ontology 12 DOID:12641
ICD9CM 34 750.6
SNOMED-CT 67 47028006
ICD10 32 Q40.1
UMLS 71 C0158674

Summaries for Displacement of Cardia Through Esophageal Hiatus

MalaCards based summary : Displacement of Cardia Through Esophageal Hiatus, also known as congenital hiatus hernia, is related to gastroesophageal reflux and postgastrectomy syndrome. An important gene associated with Displacement of Cardia Through Esophageal Hiatus is GAST (Gastrin), and among its related pathways/superpathways is Secretion of Hydrochloric Acid in Parietal Cells. Related phenotype is digestive/alimentary.

Related Diseases for Displacement of Cardia Through Esophageal Hiatus

Diseases related to Displacement of Cardia Through Esophageal Hiatus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 gastroesophageal reflux 29.3 GAST ATP4A ATP12A
2 postgastrectomy syndrome 9.9 GAST ATP12A
3 vagus nerve disease 9.9 ATP4A ATP12A
4 hemangioma of intra-abdominal structure 9.9 ATP4A ATP12A
5 acquired gastric outlet stenosis 9.9 ATP4A ATP12A
6 angiodysplasia of intestine 9.9 ATP4A ATP12A
7 angiodysplasia 9.9 ATP4A ATP12A
8 benzylpenicillin allergy 9.9 ATP4A ATP12A
9 penicillin allergy 9.9 ATP4A ATP12A
10 bacterial esophagitis 9.9 ATP4A ATP12A
11 lingual goiter 9.9 ATP4A ATP12A
12 cascade stomach 9.9 ATP4A ATP12A
13 gastrojejunal ulcer 9.9 ATP4A ATP12A
14 median arcuate ligament syndrome 9.9 ATP4A ATP12A
15 laryngeal tuberculosis 9.9 ATP4A ATP12A
16 fungal esophagitis 9.9 ATP4A ATP12A
17 dieulafoy lesion 9.9 ATP4A ATP12A
18 esophagus melanoma 9.8 ATP4A ATP12A
19 emphysematous cholecystitis 9.8 ATP4A ATP12A
20 necrotizing gastritis 9.8 ATP4A ATP12A
21 cervix erosion 9.8 ATP4A ATP12A
22 pneumatosis cystoides intestinalis 9.8 ATP4A ATP12A
23 superior mesenteric artery syndrome 9.8 ATP4A ATP12A
24 chronic laryngitis 9.8 ATP4A ATP12A
25 laryngitis 9.8 ATP4A ATP12A
26 cefuroxime allergy 9.8 ATP4A ATP12A
27 polyposis, skin pigmentation, alopecia, and fingernail changes 9.8 ATP4A ATP12A
28 chronic intestinal vascular insufficiency 9.8 ATP4A ATP12A
29 rumination disorder 9.8 ATP4A ATP12A
30 blind loop syndrome 9.8 ATP4A ATP12A
31 acute laryngitis 9.8 ATP4A ATP12A
32 gastric hemangioma 9.8 ATP4A ATP12A
33 internal hemorrhoid 9.8 ATP4A ATP12A
34 hemorrhoid 9.8 ATP4A ATP12A
35 gastric dilatation 9.8 ATP4A ATP12A
36 scalp dermatosis 9.8 ATP4A ATP12A
37 central nervous system origin vertigo 9.8 ATP4A ATP12A
38 diclofenac allergy 9.8 ATP4A ATP12A
39 lymphocytic gastritis 9.8 ATP4A ATP12A
40 x-linked chondrodysplasia punctata 1 9.8 ATP4A ATP12A
41 gastroduodenal crohn's disease 9.8 ATP4A ATP12A
42 eosinophilic gastritis 9.8 ATP4A ATP12A
43 duodenal obstruction 9.8 ATP4A ATP12A
44 functional diarrhea 9.8 ATP4A ATP12A
45 diarrhea 1, secretory chloride, congenital 9.8 ATP4A ATP12A
46 barbiturate abuse 9.8 ATP4A ATP12A
47 epidermolysis bullosa simplex, ogna type 9.8 ATP4A ATP12A
48 mediastinitis 9.8 ATP4A ATP12A
49 aspiration pneumonitis 9.8 ATP4A ATP12A
50 outlet dysfunction constipation 9.8 ATP4A ATP12A

Graphical network of the top 20 diseases related to Displacement of Cardia Through Esophageal Hiatus:



Diseases related to Displacement of Cardia Through Esophageal Hiatus

Symptoms & Phenotypes for Displacement of Cardia Through Esophageal Hiatus

MGI Mouse Phenotypes related to Displacement of Cardia Through Esophageal Hiatus:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 ATP12A ATP4A GAST IHH

Drugs & Therapeutics for Displacement of Cardia Through Esophageal Hiatus

Search Clinical Trials , NIH Clinical Center for Displacement of Cardia Through Esophageal Hiatus

Genetic Tests for Displacement of Cardia Through Esophageal Hiatus

Anatomical Context for Displacement of Cardia Through Esophageal Hiatus

Publications for Displacement of Cardia Through Esophageal Hiatus

Articles related to Displacement of Cardia Through Esophageal Hiatus:

# Title Authors PMID Year
1
Congenital hiatus hernia: A case series. 61
31297485 2019
2
Congenital hiatus hernia identified retrospectively on pediatric pertechnetate imaging. 61
20305425 2010
3
[Congenital hiatus hernia associated with reflux esophageal stenosis]. 61
15615465 2004
4
Congenital hiatus hernia. 61
6074850 1967
5
[Morphology and pathogenesis of congenital hiatus hernia and thoracic stomach with congenitally short esophagus]. 61
13551025 1958
6
[Congenital hiatus hernia with short esophagus in children]. 61
14859975 1951
7
Congenital hiatus hernia. 61
15394801 1949

Variations for Displacement of Cardia Through Esophageal Hiatus

Expression for Displacement of Cardia Through Esophageal Hiatus

Search GEO for disease gene expression data for Displacement of Cardia Through Esophageal Hiatus.

Pathways for Displacement of Cardia Through Esophageal Hiatus

Pathways related to Displacement of Cardia Through Esophageal Hiatus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.32 GAST ATP4A

GO Terms for Displacement of Cardia Through Esophageal Hiatus

Biological processes related to Displacement of Cardia Through Esophageal Hiatus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proton transmembrane transport GO:1902600 9.37 ATP4A ATP12A
2 potassium ion import across plasma membrane GO:1990573 9.32 ATP4A ATP12A
3 cellular sodium ion homeostasis GO:0006883 9.26 ATP4A ATP12A
4 sodium ion export across plasma membrane GO:0036376 9.16 ATP4A ATP12A
5 cellular potassium ion homeostasis GO:0030007 8.96 ATP4A ATP12A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP4A ATP12A

Molecular functions related to Displacement of Cardia Through Esophageal Hiatus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Displacement of Cardia Through Esophageal Hiatus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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