Disseminated Chorioretinitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Disseminated Chorioretinitis

MalaCards integrated aliases for Disseminated Chorioretinitis:

Name: Disseminated Chorioretinitis ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the eye and adnexa

Disorders of choroid and retina

Chorioretinal inflammation

Disseminated chorioretinal inflammation

External Ids:

Disease Ontology ¹² DOID:8787

ICD9CM ³⁴ 363.1

SNOMED-CT ⁶⁷ 78769001

ICD10 ³² H30.1

UMLS ⁷¹ C0154879

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Summaries for Disseminated Chorioretinitis

MalaCards based summary : Disseminated Chorioretinitis is related to chorioretinitis and birdshot chorioretinopathy. An important gene associated with Disseminated Chorioretinitis is GNPTAB (N-Acetylglucosamine-1-Phosphate Transferase Subunits Alpha And Beta), and among its related pathways/superpathways are PAK Pathway and TRAF Pathway. Affiliated tissues include eye and retina, and related phenotypes are growth/size/body region and mortality/aging

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Related Diseases for Disseminated Chorioretinitis

Diseases related to Disseminated Chorioretinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)

#	Related Disease	Score	Top Affiliating Genes
1	chorioretinitis	29.8	TNFRSF1B MRAP
2	birdshot chorioretinopathy	10.5
3	posterior uveitis	10.5
4	non-infectious posterior uveitis	10.5
5	ankylosing spondylitis 1	10.2	TNFRSF1B GPT
6	granulomatous hepatitis	10.1	TNFRSF1B GPT
7	glaucomatocyclitic crisis	10.1	MRAP CYP11B1
8	fuchs' heterochromic uveitis	10.1	MRAP CYP11B1
9	nasopharyngitis	10.1	TNFRSF1B GPT
10	pharyngitis	10.0	TNFRSF1B GPT
11	intermediate uveitis	10.0	TGFBR3 MRAP
12	pericardium disease	10.0	TNFRSF1B GPT
13	anterior scleritis	10.0	TNFRSF1B MRAP
14	scleritis	10.0	TNFRSF1B MRAP
15	juvenile ankylosing spondylitis	10.0	TNFRSF1B MRAP
16	aneurysmal bone cysts	10.0	TNFSF11 TNFRSF11A
17	orbital plasma cell granuloma	10.0	TNFRSF1B MRAP
18	chronic orbital inflammation	9.9	TNFRSF1B MRAP
19	optic papillitis	9.9	TNFRSF1B MRAP
20	ankylosing spondylitis 3	9.9	TNFRSF1B MRAP
21	corneal dystrophy, band-shaped	9.9	TNFRSF1B MRAP
22	aortitis	9.9	TNFRSF1B MRAP
23	hypopyon	9.9	TNFRSF1B MRAP
24	tenosynovitis	9.9	TNFRSF1B MRAP
25	pustulosis of palm and sole	9.9	TNFRSF1B MRAP
26	chondromalacia	9.9	TNFRSF1B MRAP
27	scleral disease	9.9	TNFRSF1B MRAP
28	giant cell reparative granuloma	9.9	TNFSF11 TNFRSF11A
29	osteopetrosis, autosomal recessive 4	9.9	TNFSF11 GFER
30	bursitis	9.9	TNFRSF1B MRAP
31	enthesopathy	9.9	TNFRSF1B MRAP
32	iritis	9.9	TNFRSF1B MRAP
33	sapho syndrome	9.9	TNFRSF1B MRAP
34	osteopetrosis, autosomal recessive 6	9.9	TNFSF11 GFER
35	choroiditis	9.9	TNFRSF1B MRAP
36	tendinitis	9.9	TNFRSF1B MRAP
37	macular dystrophy, dominant cystoid	9.9	TNFRSF1B MRAP
38	retinal vasculitis	9.9	TNFRSF1B MRAP
39	histoplasmosis	9.9
40	periodontitis, chronic	9.8	TNFSF11 TNFRSF11B
41	multicentric reticulohistiocytosis	9.8	TNFSF11 TNFRSF11B
42	osteopetrosis, autosomal recessive 7	9.8	TNFSF11 TNFRSF11A GFER
43	chronic apical periodontitis	9.8	TNFSF11 TNFRSF11B
44	kummell's disease	9.8	TNFSF11 TNFRSF11B
45	periostitis	9.8	TNFRSF11B TNFRSF11A MRAP
46	iridocyclitis	9.7	TNFRSF1B MRAP CYP11B1
47	periapical periodontitis	9.7	TNFSF11 TNFRSF11B
48	poems syndrome	9.7	TNFSF11 TNFRSF11B
49	pigmented villonodular synovitis	9.7	TNFSF11 TNFRSF11B
50	gingival disease	9.6	TNFSF11 TNFRSF11B

Graphical network of the top 20 diseases related to Disseminated Chorioretinitis:

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Symptoms & Phenotypes for Disseminated Chorioretinitis

MGI Mouse Phenotypes related to Disseminated Chorioretinitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	9.97	CHL1 CYP11B1 GFER GNPTAB TGFBR3 TNFRSF11A
2	mortality/aging	MP:0010768	9.96	CYP11B1 GFER GNPTAB MRAP SDHB TGFBR3
3	craniofacial	MP:0005382	9.95	CHL1 GNPTAB TGFBR3 TNFRSF11A TNFRSF11B TNFRSF1B
4	endocrine/exocrine gland	MP:0005379	9.91	CYP11B1 GNPTAB MRAP SDHB TNFRSF11A TNFRSF1B
5	neoplasm	MP:0002006	9.55	GFER SDHB TNFRSF11A TNFRSF1B TNFSF11
6	respiratory system	MP:0005388	9.43	CHL1 GNPTAB MRAP TNFRSF11A TNFRSF1B TNFSF11
7	skeleton	MP:0005390	9.17	GNPTAB GPT TGFBR3 TNFRSF11A TNFRSF11B TNFRSF1B

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Drugs & Therapeutics for Disseminated Chorioretinitis

Search Clinical Trials , NIH Clinical Center for Disseminated Chorioretinitis

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Genetic Tests for Disseminated Chorioretinitis

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Anatomical Context for Disseminated Chorioretinitis

MalaCards organs/tissues related to Disseminated Chorioretinitis:

⁴⁰

Eye, Retina

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Publications for Disseminated Chorioretinitis

Articles related to Disseminated Chorioretinitis:

#	Title	Authors	PMID	Year
1	Choroidal Manifestation of Systemic Non-Tuberculous Mycobacterial Infection: A Case Series. ⁶¹	Sinner V...Todorova M	32219781	2020
2	Advantages and limitations of the spatially adaptive program SAPRO in clinical perimetry. ⁶¹	Fankhauser F...Kwasniewska S	3755124	1986
3	Subacute sclerosing panencephalitis (SSPE). A case report. ⁶¹	Brudet-Wickel CL...de Wolff-Rouendaal D	7067595	1982
4	[Recurrent disseminated chorioretinitis due to acquired histoplasmosis (author's transl)]. ⁶¹	Bernardczykowa A...Ziobrowski S	672116	1978

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Genes for Disseminated Chorioretinitis

Genes related to Disseminated Chorioretinitis (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GNPTAB	N-Acetylglucosamine-1-Phosphate Transferase Subunits Alpha And Beta	Protein Coding	6.42	DISEASES inferred ¹⁵
2	GFER	Growth Factor, Augmenter Of Liver Regeneration	Protein Coding	4.95	DISEASES inferred ¹⁵
3	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	4.89	DISEASES inferred ¹⁵
4	TNFRSF11A	TNF Receptor Superfamily Member 11a	Protein Coding	4.71	DISEASES inferred ¹⁵
5	CYP11B1	Cytochrome P450 Family 11 Subfamily B Member 1	Protein Coding	4.69	DISEASES inferred ¹⁵
6	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	4.33	DISEASES inferred ¹⁵
7	CHL1	Cell Adhesion Molecule L1 Like	Protein Coding	4.3	DISEASES inferred ¹⁵
8	A2M	Alpha-2-Macroglobulin	Protein Coding	4.27	DISEASES inferred ¹⁵
9	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	4.07	DISEASES inferred ¹⁵
10	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	3.87	DISEASES inferred ¹⁵
11	MRAP	Melanocortin 2 Receptor Accessory Protein	Protein Coding	3.54	DISEASES inferred ¹⁵
12	TNFSF11	TNF Superfamily Member 11	Protein Coding	3.53	DISEASES inferred ¹⁵
13	TNFRSF1B	TNF Receptor Superfamily Member 1B	Protein Coding	3.48	DISEASES inferred ¹⁵

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Variations for Disseminated Chorioretinitis

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Expression for Disseminated Chorioretinitis

Search GEO for disease gene expression data for Disseminated Chorioretinitis.

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Pathways for Disseminated Chorioretinitis

Pathways related to Disseminated Chorioretinitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	12.92	TNFSF11 TNFRSF1B TNFRSF11A TGFBR3 GFER
2	TRAF Pathway ⁶³ Show member pathways 14-3-3 Induced Apoptosis ⁶³ TNF Superfamily Pathway ⁶³ Toll-Like Receptors Pathway ⁶³	12.15	TNFSF11 TNFRSF1B TNFRSF11B TNFRSF11A
3	Apoptosis and Autophagy ⁴	11.88	TNFSF11 TNFRSF1B TNFRSF11A
4	Osteoclast differentiation ³⁶	11.69	TNFSF11 TNFRSF11B TNFRSF11A
5	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway ²² Show member pathways Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway ²²	11.3	TNFSF11 TNFRSF1B TNFRSF11A
6	TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions ⁶⁴ Show member pathways TNFs bind their physiological receptors ⁶⁵	11.17	TNFSF11 TNFRSF1B TNFRSF11B TNFRSF11A
7	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	10.99	TNFSF11 TNFRSF11B TNFRSF11A
8	Osteoblast Signaling ¹	10.51	TNFSF11 TNFRSF11B
9	Osteoclast Signaling ¹	10	TNFSF11 TNFRSF11B TNFRSF11A

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GO Terms for Disseminated Chorioretinitis

Cellular components related to Disseminated Chorioretinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.17	TNFSF11 TNFRSF1B TNFRSF11B TGFBR3 GFER CHL1

Biological processes related to Disseminated Chorioretinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.71	TNFSF11 TNFRSF1B TGFBR3 CYP11B1
2	osteoclast differentiation	GO:0030316	9.43	TNFSF11 TNFRSF11A
3	positive regulation of bone resorption	GO:0045780	9.37	TNFSF11 TNFRSF11A
4	mammary gland alveolus development	GO:0060749	9.32	TNFSF11 TNFRSF11A
5	TNFSF11-mediated signaling pathway	GO:0071847	9.26	TNFSF11 TNFRSF11A
6	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling	GO:0071848	9.16	TNFSF11 TNFRSF11A
7	positive regulation of fever generation by positive regulation of prostaglandin secretion	GO:0071812	8.96	TNFSF11 TNFRSF11A
8	tumor necrosis factor-mediated signaling pathway	GO:0033209	8.92	TNFSF11 TNFRSF1B TNFRSF11B TNFRSF11A

Molecular functions related to Disseminated Chorioretinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	tumor necrosis factor-activated receptor activity	GO:0005031	8.96	TNFRSF1B TNFRSF11A
2	tumor necrosis factor binding	GO:0043120	8.62	TNFRSF1B A2M

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