Disseminated Chorioretinitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Disseminated Chorioretinitis

MalaCards integrated aliases for Disseminated Chorioretinitis:

Name: Disseminated Chorioretinitis ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the eye and adnexa

Disorders of choroid and retina

Chorioretinal inflammation

Disseminated chorioretinal inflammation

External Ids:

Disease Ontology ¹² DOID:8787

ICD9CM ³⁴ 363.1

SNOMED-CT ⁶⁷ 78769001

ICD10 ³² H30.1

UMLS ⁷¹ C0154879

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Summaries for Disseminated Chorioretinitis

MalaCards based summary : Disseminated Chorioretinitis is related to periostitis and periodontitis, chronic. An important gene associated with Disseminated Chorioretinitis is GNPTAB (N-Acetylglucosamine-1-Phosphate Transferase Subunits Alpha And Beta), and among its related pathways/superpathways are TRAF Pathway and RANK Signaling in Osteoclasts. Affiliated tissues include eye and retina, and related phenotypes are craniofacial and immune system

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Related Diseases for Disseminated Chorioretinitis

Diseases related to Disseminated Chorioretinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)

#	Related Disease	Score	Top Affiliating Genes
1	periostitis	10.1	TNFRSF11B TNFRSF11A
2	periodontitis, chronic	10.1	TNFSF11 TNFRSF11B
3	multicentric reticulohistiocytosis	10.1	TNFSF11 TNFRSF11B
4	chronic apical periodontitis	10.1	TNFSF11 TNFRSF11B
5	craniometaphyseal dysplasia, autosomal dominant	10.0	TNFSF11 TNFRSF11B
6	aneurysmal bone cysts	10.0	TNFSF11 TNFRSF11A
7	giant cell reparative granuloma	10.0	TNFSF11 TNFRSF11A
8	glucocorticoid-induced osteoporosis	10.0	TNFSF11 TNFRSF11B
9	tooth resorption	10.0	TNFSF11 TNFRSF11A
10	osteopetrosis, autosomal recessive 7	10.0	TNFSF11 TNFRSF11A
11	renal osteodystrophy	10.0	TNFSF11 TNFRSF11B
12	ischemic bone disease	10.0	TNFSF11 TNFRSF11A
13	ankylosis	10.0	TNFSF11 TNFRSF11B
14	cellulitis	9.9	TNFSF11 GPT
15	fibrous dysplasia	9.9	TNFSF11 TNFRSF11A
16	osteonecrosis	9.9	TNFSF11 TNFRSF11B
17	histoplasmosis	9.9
18	chorioretinitis	9.9
19	polyarticular onset juvenile idiopathic arthritis	9.9	TNFSF11 TNFRSF11B TNFRSF11A
20	hemophilic arthropathy	9.9	TNFSF11 TNFRSF11B TNFRSF11A
21	arthropathy	9.8	TNFSF11 TNFRSF11B TNFRSF11A
22	paget disease of bone 5, juvenile-onset	9.8	TNFSF11 TNFRSF11B TNFRSF11A
23	multicentric carpotarsal osteolysis syndrome	9.8	TNFSF11 TNFRSF11B TNFRSF11A
24	root resorption	9.8	TNFSF11 TNFRSF11B TNFRSF11A
25	familial expansile osteolysis	9.8	TNFSF11 TNFRSF11B TNFRSF11A
26	benign giant cell tumor	9.8	TNFSF11 TNFRSF11B TNFRSF11A
27	mammary paget's disease	9.8	TNFSF11 TNFRSF11B TNFRSF11A
28	paget's disease of bone	9.8	TNFSF11 TNFRSF11B TNFRSF11A
29	bone resorption disease	9.8	TNFSF11 TNFRSF11B TNFRSF11A
30	bone remodeling disease	9.8	TNFSF11 TNFRSF11B TNFRSF11A
31	spondyloarthropathy 1	9.8	TNFSF11 TNFRSF11B
32	osteopetrosis	9.8	TNFSF11 TNFRSF11B TNFRSF11A
33	brittle bone disorder	9.8	TNFSF11 TNFRSF11B TNFRSF11A
34	far eastern spotted fever	9.8	SDHB GPT
35	bone disease	9.8	TNFSF11 TNFRSF11B TNFRSF11A
36	endosteal hyperostosis, autosomal dominant	9.7	TNFSF11 TNFRSF11B
37	myoglobinuria	9.7	SDHB GPT
38	scoliosis	9.6	TNFSF11 TNFRSF11B TNFRSF11A

Graphical network of the top 20 diseases related to Disseminated Chorioretinitis:

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Symptoms & Phenotypes for Disseminated Chorioretinitis

MGI Mouse Phenotypes related to Disseminated Chorioretinitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial	MP:0005382	9.65	GNPTAB TGFBR3 TNFRSF11A TNFRSF11B TNFSF11
2	immune system	MP:0005387	9.63	GNPTAB SDHB TGFBR3 TNFRSF11A TNFRSF11B TNFSF11
3	limbs/digits/tail	MP:0005371	9.35	GNPTAB TGFBR3 TNFRSF11A TNFRSF11B TNFSF11
4	skeleton	MP:0005390	9.1	GNPTAB GPT TGFBR3 TNFRSF11A TNFRSF11B TNFSF11

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Drugs & Therapeutics for Disseminated Chorioretinitis

Search Clinical Trials , NIH Clinical Center for Disseminated Chorioretinitis

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Genetic Tests for Disseminated Chorioretinitis

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Anatomical Context for Disseminated Chorioretinitis

MalaCards organs/tissues related to Disseminated Chorioretinitis:

⁴⁰

Eye, Retina

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Publications for Disseminated Chorioretinitis

Articles related to Disseminated Chorioretinitis:

#	Title	Authors	PMID	Year
1	Choroidal Manifestation of Systemic Non-Tuberculous Mycobacterial Infection: A Case Series. ⁶¹	Sinner V...Todorova M	32219781	2020
2	Advantages and limitations of the spatially adaptive program SAPRO in clinical perimetry. ⁶¹	Fankhauser F...Kwasniewska S	3755124	1986
3	Subacute sclerosing panencephalitis (SSPE). A case report. ⁶¹	Brudet-Wickel CL...de Wolff-Rouendaal D	7067595	1982
4	[Recurrent disseminated chorioretinitis due to acquired histoplasmosis (author's transl)]. ⁶¹	Bernardczykowa A...Ziobrowski S	672116	1978

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Genes for Disseminated Chorioretinitis

Genes related to Disseminated Chorioretinitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GNPTAB	N-Acetylglucosamine-1-Phosphate Transferase Subunits Alpha And Beta	Protein Coding	6.58	DISEASES inferred ¹⁵
2	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	5.07	DISEASES inferred ¹⁵
3	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	4.95	DISEASES inferred ¹⁵
4	TNFRSF11A	TNF Receptor Superfamily Member 11a	Protein Coding	4.89	DISEASES inferred ¹⁵
5	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	4.39	DISEASES inferred ¹⁵
6	A2M	Alpha-2-Macroglobulin	Protein Coding	4.33	DISEASES inferred ¹⁵
7	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	4.12	DISEASES inferred ¹⁵
8	TNFSF11	TNF Superfamily Member 11	Protein Coding	3.59	DISEASES inferred ¹⁵

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Variations for Disseminated Chorioretinitis

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Expression for Disseminated Chorioretinitis

Search GEO for disease gene expression data for Disseminated Chorioretinitis.

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Pathways for Disseminated Chorioretinitis

Pathways related to Disseminated Chorioretinitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	TRAF Pathway ⁶³ Show member pathways 14-3-3 Induced Apoptosis ⁶³ TNF Superfamily Pathway ⁶³ Toll-Like Receptors Pathway ⁶³	12.11	TNFSF11 TNFRSF11B TNFRSF11A
2	RANK Signaling in Osteoclasts ⁶³ Show member pathways Apoptosis and survival APRIL and BAFF signaling ²³ APRIL Pathway ⁶³ BAFF in B-Cell Signaling ⁶³ RANK Pathway ⁶³ RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway ¹	11.94	TNFSF11 TNFRSF11B TNFRSF11A
3	Osteoclast differentiation ³⁶	11.54	TNFSF11 TNFRSF11B TNFRSF11A
4	IL6-mediated signaling events ¹ Show member pathways IL-6 signaling pathway ¹	11.39	TNFSF11 A2M
5	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway ²³ Show member pathways Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway ²³	11.3	TNFSF11 TNFRSF11A
6	TNF Superfamily Pathway: Human Ligand-Receptor Interactions and their Associated Functions ⁶⁴ Show member pathways TNFs bind their physiological receptors ⁶⁵	11.25	TNFSF11 TNFRSF11B TNFRSF11A
7	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²³	10.79	TNFSF11 TNFRSF11B TNFRSF11A
8	Osteoblast Signaling ¹	10.47	TNFSF11 TNFRSF11B
9	Osteoclast Signaling ¹	10	TNFSF11 TNFRSF11B TNFRSF11A

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GO Terms for Disseminated Chorioretinitis

Cellular components related to Disseminated Chorioretinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.02	TNFSF11 TNFRSF11B TGFBR3 GPT A2M

Biological processes related to Disseminated Chorioretinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	monocyte chemotaxis	GO:0002548	9.43	TNFSF11 TNFRSF11A
2	tumor necrosis factor-mediated signaling pathway	GO:0033209	9.43	TNFSF11 TNFRSF11B TNFRSF11A
3	osteoclast differentiation	GO:0030316	9.4	TNFSF11 TNFRSF11A
4	positive regulation of bone resorption	GO:0045780	9.37	TNFSF11 TNFRSF11A
5	mammary gland alveolus development	GO:0060749	9.32	TNFSF11 TNFRSF11A
6	TNFSF11-mediated signaling pathway	GO:0071847	9.16	TNFSF11 TNFRSF11A
7	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling	GO:0071848	8.96	TNFSF11 TNFRSF11A
8	positive regulation of fever generation by positive regulation of prostaglandin secretion	GO:0071812	8.62	TNFSF11 TNFRSF11A

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Sources for Disseminated Chorioretinitis

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