MCID: DSS003
MIFTS: 26

Disseminated Eosinophilic Collagen Disease

Categories: Blood diseases

Aliases & Classifications for Disseminated Eosinophilic Collagen Disease

MalaCards integrated aliases for Disseminated Eosinophilic Collagen Disease:

Name: Disseminated Eosinophilic Collagen Disease 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:9499
SNOMED-CT 67 423486005
UMLS 71 C0263662

Summaries for Disseminated Eosinophilic Collagen Disease

MalaCards based summary : Disseminated Eosinophilic Collagen Disease is related to hypereosinophilic syndrome and collagen disease. An important gene associated with Disseminated Eosinophilic Collagen Disease is CHIC2 (Cysteine Rich Hydrophobic Domain 2), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Related phenotypes are Reduced mammosphere formation and hematopoietic system

Related Diseases for Disseminated Eosinophilic Collagen Disease

Diseases related to Disseminated Eosinophilic Collagen Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 hypereosinophilic syndrome 30.0 RNASE3 PDGFRA IL5RA IL5 IL3 IL2RA
2 collagen disease 10.6
3 pdgfra-associated chronic eosinophilic leukemia 10.3 PDGFRA FIP1L1
4 primary hypereosinophilic syndrome 10.3 PDGFRA FIP1L1
5 childhood-onset asthma 10.3 RNASE3 EPX
6 inflammatory bowel disease 4 10.3 RNASE3 EPX
7 myeloid and lymphoid neoplasms associated with pdgfra rearrangement 10.2 PDGFRA FIP1L1 CHIC2
8 sm-ahnmd 10.2 PDGFRA FIP1L1 CHIC2
9 loeffler syndrome 10.2 IL5 FIP1L1
10 loiasis 10.2 IL5 EPX
11 toxic oil syndrome 10.2 IL5 IL2RA
12 b cell prolymphocytic leukemia 10.2 IL2RA CD5
13 lymphoproliferative syndrome 1 10.2 IL2RA CD52
14 acute asthma 10.2 RNASE3 IL5
15 mansonelliasis 10.1 IL5 CCL17
16 vernal conjunctivitis 10.1 RNASE3 IL2RA EPX
17 chronic asthma 10.1 RNASE3 IL5
18 stevens-johnson syndrome/toxic epidermal necrolysis 10.1 IL5 CCL17
19 cough variant asthma 10.1 RNASE3 IL5
20 eosinophilia-myalgia syndrome 10.1 RNASE2 IL5 FIP1L1
21 patulous eustachian tube 10.1 RNASE3 IL5
22 timothy grass allergy 10.1 RNASE3 IL5
23 parapsoriasis 10.1 CD7 CD5
24 allergic bronchopulmonary aspergillosis 10.1 IL5 EPX CCL17
25 vernal keratoconjunctivitis 10.1 RNASE3 IL5
26 aspergillosis 10.1 IL5 EPX CCL17
27 pemphigoid gestationis 10.1 RNASE3 IL5
28 follicular mucinosis 10.1 CD7 CD5
29 esophagitis 10.1 RNASE3 IL5RA IL5
30 vasomotor rhinitis 10.1 RNASE3 IL5
31 t-cell prolymphocytic leukemia 10.1 CD7 CD52
32 toxocariasis 10.1 RNASE3 IL5 FIP1L1
33 elephantiasis 10.0 RNASE3 IL5
34 paragonimiasis 10.0 RNASE3 IL5 CCL17
35 conjunctivitis 10.0 RNASE3 IL5 EPX
36 red cell aplasia 10.0 IL2RA IFNA1
37 cryoglobulinemia, familial mixed 10.0 IFNA1 CD5
38 chronic rhinitis 10.0 RNASE3 IL5 EPX
39 rhinitis 10.0 RNASE3 IL5 EPX
40 allergic contact dermatitis 10.0 IL5 IL2RA CCL17
41 urinary schistosomiasis 10.0 RNASE3 IL5 EPX
42 echinococcosis 10.0 RNASE3 IL5 CCL17
43 aggressive systemic mastocytosis 10.0 PDGFRA IFNA1 FIP1L1
44 peripheral nervous system disease 10.0
45 neuropathy 10.0
46 wells syndrome 10.0 RNASE3 IL5 IL2RA
47 onchocerciasis 10.0 RNASE3 IL5 EPX
48 parasitic helminthiasis infectious disease 10.0 RNASE3 IL5 EPX
49 nail disorder, nonsyndromic congenital, 1 10.0 PDGFRA FIP1L1
50 food allergy 10.0 RNASE3 IL5 EPX

Graphical network of the top 20 diseases related to Disseminated Eosinophilic Collagen Disease:



Diseases related to Disseminated Eosinophilic Collagen Disease

Symptoms & Phenotypes for Disseminated Eosinophilic Collagen Disease

GenomeRNAi Phenotypes related to Disseminated Eosinophilic Collagen Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CD27 CD5 CD52 CD7 IL2RA IL5

MGI Mouse Phenotypes related to Disseminated Eosinophilic Collagen Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CCL17 CD27 CD5 CD7 CHIC2 EPX
2 immune system MP:0005387 9.36 CCL17 CD27 CD5 CD7 CHIC2 EPX

Drugs & Therapeutics for Disseminated Eosinophilic Collagen Disease

Search Clinical Trials , NIH Clinical Center for Disseminated Eosinophilic Collagen Disease

Genetic Tests for Disseminated Eosinophilic Collagen Disease

Anatomical Context for Disseminated Eosinophilic Collagen Disease

Publications for Disseminated Eosinophilic Collagen Disease

Articles related to Disseminated Eosinophilic Collagen Disease:

(show all 15)
# Title Authors PMID Year
1
[Disseminated eosinophilic collagen disease]. 61
11212817 2000
2
[Recurrent eosinophilic pneumonia. Bibliographical review, nosographic, pathogenetic and unitary setting reflections on the disease]. 61
3574733 1987
3
[Case of disseminated eosinophilic collagen disease with peripheral neuropathy and increase in the serum immune complexes]. 61
6327135 1983
4
Serum IgE and IgE antibody levels in patients with bronchial asthma, atopic dermatitis, eosinophilic granulomas of the soft tissue (Kimura's disease) and other diseases. 61
6600385 1983
5
[Dermal lesions in hematological diseases and their care - nursing of a patient with disseminated eosinophilic collagen disease]. 61
259119 1979
6
[A case of disseminated eosinophilic collagen disease (author's transl)]. 61
422899 1979
7
Hypereosinophilic multiple thrombosis. A proposal of a new designation of disseminated eosinophilic "collagen disease". 61
869293 1977
8
[Dry coughs and exertion-induced dyspnea (thoracic radiography and eosinophil count): (disseminated eosinophilic collagen disease)]. 61
611208 1977
9
[A case of disseminated eosinophilic collagen disease (author's transl)]. 61
1034750 1976
10
[A case of disseminated eosinophilic collagen disease (author's transl)]. 61
1240981 1975
11
Clinicopathologic conference: Disseminated eosinophilic collagen disease. 61
4812077 1974
12
[Eosinophilic leukemia or disseminated eosinophilic collagen disease? (apropos of severe nonparasitic eosinophilia)]. 61
5498872 1970
13
Disseminated eosinophilic collagen disease. 61
6023068 1967
14
EOSINOPHILIC LEUKEMIA AND DISSEMINATED EOSINOPHILIC COLLAGEN DISEASE--A DISEASE ENTITY? 61
14279494 1965
15
Disseminated eosinophilic collagen disease; a clinical and pathological study of a clinical entity related to Löffler's syndromes. 61
13301467 1956

Variations for Disseminated Eosinophilic Collagen Disease

Expression for Disseminated Eosinophilic Collagen Disease

Search GEO for disease gene expression data for Disseminated Eosinophilic Collagen Disease.

Pathways for Disseminated Eosinophilic Collagen Disease

Pathways related to Disseminated Eosinophilic Collagen Disease according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.86 RNASE3 RNASE2 PDGFRA IL5RA IL5 IL3
2
Show member pathways
13.5 PDGFRA IL5RA IL5 IL3 IL2RA IFNA1
3
Show member pathways
13.2 PDGFRA IL5RA IL5 IL3 IL2RA CD27
4
Show member pathways
13.15 PDGFRA IL5RA IL5 IL3 IL2RA IFNA1
5
Show member pathways
13.09 PDGFRA IL5RA IL5 IL3 IL2RA CD27
6 12.46 PDGFRA IL5RA IL5 IL3 IL2RA IFNA1
7
Show member pathways
12.44 RNASE3 PDGFRA IL5 IL3 IL2RA IFNA1
8
Show member pathways
12.27 PDGFRA IL5RA IL5 IL2RA
9
Show member pathways
12.01 PDGFRA IL5 IL3 IL2RA IFNA1
10
Show member pathways
11.92 IL5RA IL5 IL3 IL2RA
11
Show member pathways
11.85 IL5RA IL5 IL2RA
12
Show member pathways
11.83 PDGFRA IL5RA IL5 IL3 IL2RA IFNA1
13 11.69 IL5 IL3 IL2RA CD5
14 11.62 IL5 IL2RA CD7
15
Show member pathways
11.58 IL5 IL3 IL2RA
16 11.3 IL5 IL2RA CCL17
17 11.1 IL5RA IL5 IL3 IL2RA CD7 CD5
18 11.06 IL5RA IL5 IL2RA

GO Terms for Disseminated Eosinophilic Collagen Disease

Cellular components related to Disseminated Eosinophilic Collagen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 RNASE3 RNASE2 IL5 IL3 IFNA1 EPX
2 extracellular space GO:0005615 9.61 RNASE3 RNASE2 IL5RA IL5 IL3 IFNA1
3 external side of plasma membrane GO:0009897 9.1 PDGFRA IL5RA IL2RA FCGRT CD5 CD27

Biological processes related to Disseminated Eosinophilic Collagen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 9.56 RNASE3 RNASE2 PDGFRA CCL17
2 cytokine-mediated signaling pathway GO:0019221 9.55 IL5RA IL5 IL3 IL2RA IFNA1
3 RNA catabolic process GO:0006401 9.43 RNASE3 RNASE2
4 inflammatory response to antigenic stimulus GO:0002437 9.4 IL5RA IL2RA
5 positive regulation of T cell differentiation GO:0045582 9.37 IL2RA CD27
6 MAPK cascade GO:0000165 9.35 PDGFRA IL5RA IL5 IL3 IL2RA
7 induction of bacterial agglutination GO:0043152 9.32 RNASE3 RNASE2
8 immune response GO:0006955 9.1 IL5 IL3 IL2RA FCGRT CD7 CCL17

Molecular functions related to Disseminated Eosinophilic Collagen Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 IL5 IL3 IFNA1 CCL17

Sources for Disseminated Eosinophilic Collagen Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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