Disseminated Eosinophilic Collagen Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Disseminated Eosinophilic Collagen Disease

MalaCards integrated aliases for Disseminated Eosinophilic Collagen Disease:

Name: Disseminated Eosinophilic Collagen Disease ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Blood diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:9499

SNOMED-CT ⁶⁷ 423486005

UMLS ⁷¹ C0263662

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Summaries for Disseminated Eosinophilic Collagen Disease

MalaCards based summary : Disseminated Eosinophilic Collagen Disease is related to hypereosinophilic syndrome and collagen disease. An important gene associated with Disseminated Eosinophilic Collagen Disease is FIP1L1 (Factor Interacting With PAPOLA And CPSF1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Related phenotypes are Reduced mammosphere formation and hematopoietic system

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Related Diseases for Disseminated Eosinophilic Collagen Disease

Diseases related to Disseminated Eosinophilic Collagen Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)

#	Related Disease	Score	Top Affiliating Genes
1	hypereosinophilic syndrome	30.1	RNASE3 PDGFRA IL5RA IL5 IL3 IL2RA
2	collagen disease	10.5
3	pdgfra-associated chronic eosinophilic leukemia	10.5	PDGFRA FIP1L1
4	primary hypereosinophilic syndrome	10.4	PDGFRA FIP1L1
5	myeloid and lymphoid neoplasms associated with pdgfra rearrangement	10.3	PDGFRA FIP1L1 CHIC2
6	sm-ahnmd	10.3	PDGFRA FIP1L1 CHIC2
7	loeffler syndrome	10.3	IL5 FIP1L1
8	inflammatory bowel disease 4	10.3	RNASE3 EPX
9	toxic oil syndrome	10.2	IL5 IL2RA
10	b cell prolymphocytic leukemia	10.2	IL2RA CD5
11	stevens-johnson syndrome/toxic epidermal necrolysis	10.2	IL5 CCL17
12	vernal conjunctivitis	10.2	RNASE3 IL2RA EPX
13	autoimmune lymphoproliferative syndrome, type v	10.2	CD52 CD5
14	lymphoproliferative syndrome 1	10.2	IL2RA CD52
15	eosinophilia-myalgia syndrome	10.2	RNASE2 IL5 FIP1L1
16	cough variant asthma	10.1	RNASE3 IL5
17	allergic bronchopulmonary aspergillosis	10.1	IL5 EPX CCL17
18	aspergillosis	10.1	IL5 EPX CCL17
19	vernal keratoconjunctivitis	10.1	RNASE3 IL5
20	pemphigoid gestationis	10.1	RNASE3 IL5
21	toxocariasis	10.1	RNASE3 IL5 FIP1L1
22	red cell aplasia	10.1	IL2RA IFNA1
23	paragonimiasis	10.1	RNASE3 IL5 CCL17
24	vasomotor rhinitis	10.1	RNASE3 IL5
25	conjunctivitis	10.1	RNASE3 IL5 EPX
26	wells syndrome	10.1	RNASE3 IL5 IL2RA
27	chronic rhinitis	10.1	RNASE3 IL5 EPX
28	rhinitis	10.0	RNASE3 IL5 EPX
29	echinococcosis	10.0	RNASE3 IL5 CCL17
30	aggressive systemic mastocytosis	10.0	PDGFRA IFNA1 FIP1L1
31	urinary schistosomiasis	10.0	RNASE3 IL5 EPX
32	schistosomiasis	10.0	RNASE3 IL5 EPX
33	parapsoriasis	10.0	CD7 CD5
34	onchocerciasis	10.0	RNASE3 IL5 EPX
35	elephantiasis	10.0	RNASE3 IL5
36	cryoglobulinemia, familial mixed	10.0	IFNA1 CD5
37	eosinophilic gastritis	10.0	RNASE2 IL5 FIP1L1 EPX
38	bullous pemphigoid	10.0	RNASE3 IL5 CCL17
39	food allergy	10.0	RNASE3 IL5 EPX
40	autoimmune disease of blood	10.0	IL5 CD52 CD5
41	leukemia	9.9
42	peripheral nervous system disease	9.9
43	neuropathy	9.9
44	t-cell adult acute lymphocytic leukemia	9.9	CD7 CD52 CD5
45	myeloid and lymphoid neoplasms associated with fgfr1 abnormalities	9.9	IL3 IL2RA
46	bell's palsy	9.9	IL2RA IFNA1
47	chronic mucocutaneous candidiasis	9.8	IL5 IL2RA IFNA1
48	allergic rhinitis	9.8	RNASE3 IL5 EPX CCL17
49	conjunctival disease	9.8	RNASE3 IL5 IFNA1
50	aggressive nk-cell leukemia	9.8	CD7 CD5

Graphical network of the top 20 diseases related to Disseminated Eosinophilic Collagen Disease:

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Symptoms & Phenotypes for Disseminated Eosinophilic Collagen Disease

GenomeRNAi Phenotypes related to Disseminated Eosinophilic Collagen Disease according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Reduced mammosphere formation	GR00396-S	9.17	CD27 CD5 CD52 CD7 IL2RA IL5

MGI Mouse Phenotypes related to Disseminated Eosinophilic Collagen Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.73	CCL17 CD27 CD5 CD7 CHIC2 EHD1
2	immune system	MP:0005387	9.36	CCL17 CD27 CD5 CD7 CHIC2 EPX

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Drugs & Therapeutics for Disseminated Eosinophilic Collagen Disease

Search Clinical Trials , NIH Clinical Center for Disseminated Eosinophilic Collagen Disease

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Genetic Tests for Disseminated Eosinophilic Collagen Disease

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Anatomical Context for Disseminated Eosinophilic Collagen Disease

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Publications for Disseminated Eosinophilic Collagen Disease

Articles related to Disseminated Eosinophilic Collagen Disease:

(show all 16)

#	Title	Authors	PMID	Year
1	[Disseminated eosinophilic collagen disease]. ⁶¹	Sakane T...Nagafuchi H	11212817	2000
2	[Disseminated eosinophilic collagen disease]. ⁶¹	Ishiyama T...Tomoyasu S	9833449	1998
3	[Recurrent eosinophilic pneumonia. Bibliographical review, nosographic, pathogenetic and unitary setting reflections on the disease]. ⁶¹	Curiale B	3574733	1987
4	[Case of disseminated eosinophilic collagen disease with peripheral neuropathy and increase in the serum immune complexes]. ⁶¹	Nakano T...Shindo Y	6327135	1983
5	Serum IgE and IgE antibody levels in patients with bronchial asthma, atopic dermatitis, eosinophilic granulomas of the soft tissue (Kimura's disease) and other diseases. ⁶¹	Okudaira H...Miyamoto T	6600385	1983
6	[Dermal lesions in hematological diseases and their care - nursing of a patient with disseminated eosinophilic collagen disease]. ⁶¹	Oshima Y	259119	1979
7	[A case of disseminated eosinophilic collagen disease (author's transl)]. ⁶¹	Kage M...Tanigawa K	422899	1979
8	Hypereosinophilic multiple thrombosis. A proposal of a new designation of disseminated eosinophilic "collagen disease". ⁶¹	Ishii T...Takahashi R	869293	1977
9	[Dry coughs and exertion-induced dyspnea (thoracic radiography and eosinophil count): (disseminated eosinophilic collagen disease)]. ⁶¹	Ishibashi T...Sugiyama K	611208	1977
10	[A case of disseminated eosinophilic collagen disease (author's transl)]. ⁶¹	Sarai T...Ofuji T	1034750	1976
11	[A case of disseminated eosinophilic collagen disease (author's transl)]. ⁶¹	Tsuda T...Shiokawa Y	1240981	1975
12	Clinicopathologic conference: Disseminated eosinophilic collagen disease. ⁶¹		4812077	1974
13	[Eosinophilic leukemia or disseminated eosinophilic collagen disease? (apropos of severe nonparasitic eosinophilia)]. ⁶¹	Olmer J...Gevaudan MJ	5498872	1970
14	Disseminated eosinophilic collagen disease. ⁶¹	Pierce LE...Constantine AB	6023068	1967
15	EOSINOPHILIC LEUKEMIA AND DISSEMINATED EOSINOPHILIC COLLAGEN DISEASE--A DISEASE ENTITY? ⁶¹	ODEBERG B	14279494	1965
16	Disseminated eosinophilic collagen disease; a clinical and pathological study of a clinical entity related to Löffler's syndromes. ⁶¹	ENGFELDT B...ZETTERSTROM R	13301467	1956

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Genes for Disseminated Eosinophilic Collagen Disease

Genes related to Disseminated Eosinophilic Collagen Disease (0 elite genes):

(show all 18)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FIP1L1	Factor Interacting With PAPOLA And CPSF1	Protein Coding	5.42	DISEASES inferred ¹⁵
2	CHIC2	Cysteine Rich Hydrophobic Domain 2	Protein Coding	5.26	DISEASES inferred ¹⁵
3	IL5RA	Interleukin 5 Receptor Subunit Alpha	Protein Coding	5.02	DISEASES inferred ¹⁵
4	CD52	CD52 Molecule	Protein Coding	4.96	DISEASES inferred ¹⁵
5	CCL17	C-C Motif Chemokine Ligand 17	Protein Coding	4.79	DISEASES inferred ¹⁵
6	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	4.67	DISEASES inferred ¹⁵
7	EPX	Eosinophil Peroxidase	Protein Coding	4.65	DISEASES inferred ¹⁵
8	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	4.43	DISEASES inferred ¹⁵
9	RNASE2	Ribonuclease A Family Member 2	Protein Coding	4.38	DISEASES inferred ¹⁵
10	FCGRT	Fc Fragment Of IgG Receptor And Transporter	Protein Coding	4.36	DISEASES inferred ¹⁵
11	EHD1	EH Domain Containing 1	Protein Coding	4.19	DISEASES inferred ¹⁵
12	RNASE3	Ribonuclease A Family Member 3	Protein Coding	3.99	DISEASES inferred ¹⁵
13	IL5	Interleukin 5	Protein Coding	3.97	DISEASES inferred ¹⁵
14	CD7	CD7 Molecule	Protein Coding	3.95	DISEASES inferred ¹⁵
15	IFNA1	Interferon Alpha 1	Protein Coding	3.85	DISEASES inferred ¹⁵
16	CD27	CD27 Molecule	Protein Coding	3.63	DISEASES inferred ¹⁵
17	IL3	Interleukin 3	Protein Coding	3.47	DISEASES inferred ¹⁵
18	CD5	CD5 Molecule	Protein Coding	3.43	DISEASES inferred ¹⁵

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Variations for Disseminated Eosinophilic Collagen Disease

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Expression for Disseminated Eosinophilic Collagen Disease

Search GEO for disease gene expression data for Disseminated Eosinophilic Collagen Disease.

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Pathways for Disseminated Eosinophilic Collagen Disease

Pathways related to Disseminated Eosinophilic Collagen Disease according to GeneCards Suite gene sharing:

(show all 19)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.86	RNASE3 RNASE2 PDGFRA IL5RA IL5 IL3
2	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.5	PDGFRA IL5RA IL5 IL3 IL2RA IFNA1
3	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.23	PDGFRA IL5RA IL5 IL3 IL2RA CD27
4	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	13.15	PDGFRA IL5RA IL5 IL3 IL2RA IFNA1
5	Response to elevated platelet cytosolic Ca2+ ⁶⁵ Show member pathways Disinhibition of SNARE formation ⁶⁵ Hemostasis ⁶⁵ Platelet activation, signaling and aggregation ⁶⁵ Platelet degranulation ⁶⁵	13.14	IL5RA IL5 IL3 IL2RA IFNA1 EHD1
6	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.09	PDGFRA IL5RA IL5 IL3 IL2RA CD27
7	Pathways in cancer ³⁶	12.46	PDGFRA IL5RA IL5 IL3 IL2RA IFNA1
8	Apoptosis Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ NF-kappaB Pathway ⁷⁰	12.27	PDGFRA IL5RA IL5 IL2RA
9	Allograft rejection ¹ ³⁶ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.24	RNASE3 PDGFRA IL5 IL3 IL2RA IFNA1
10	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	12.03	PDGFRA IL5RA IL5 IL3 IL2RA IFNA1
11	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶³ Interferon alpha/beta signaling ⁶⁵ Regulation of IFNA signaling ⁶⁵	12.01	PDGFRA IL5 IL3 IL2RA IFNA1
12	G beta-gamma signalling through PI3Kgamma ⁶⁵ Show member pathways G-protein beta-gamma signalling ⁶⁵ GPVI-mediated activation cascade ⁶⁵	11.92	IL5RA IL5 IL3 IL2RA
13	MAPK Pathway ⁷⁰ Show member pathways Toll-like Receptor Pathway ⁷⁰	11.85	IL5RA IL5 IL2RA
14	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁴	11.69	IL5 IL3 IL2RA CD5
15	Innate Lymphoid Cells Differentiation ⁶⁴	11.6	IL5 IL2RA CD7
16	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.57	IL5 IL3 IL2RA
17	Th2 Differentiation ⁶⁴	11.3	IL5 IL2RA CCL17
18	Hematopoietic cell lineage ³⁶	11.1	IL5RA IL5 IL3 IL2RA CD7 CD5
19	Inflammatory Response Pathway ¹	11.06	IL5RA IL5 IL2RA

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GO Terms for Disseminated Eosinophilic Collagen Disease

Cellular components related to Disseminated Eosinophilic Collagen Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.76	RNASE3 IL5RA IL5 IL3 IFNA1 FCGRT
2	extracellular region	GO:0005576	9.61	RNASE3 RNASE2 IL5 IL3 IFNA1 EPX
3	external side of plasma membrane	GO:0009897	9.1	PDGFRA IL5RA IL2RA FCGRT CD5 CD27

Biological processes related to Disseminated Eosinophilic Collagen Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine-mediated signaling pathway	GO:0019221	9.55	IL5RA IL5 IL3 IL2RA IFNA1
2	MAPK cascade	GO:0000165	9.35	PDGFRA IL5RA IL5 IL3 IL2RA
3	positive regulation of T cell differentiation	GO:0045582	9.32	IL2RA CD27
4	induction of bacterial agglutination	GO:0043152	9.26	RNASE3 RNASE2
5	immune response	GO:0006955	9.1	IL5 IL3 IL2RA FCGRT CD7 CCL17

Molecular functions related to Disseminated Eosinophilic Collagen Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	8.92	IL5 IL3 IFNA1 CCL17

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