DIC
MCID: DSS009
MIFTS: 58

Disseminated Intravascular Coagulation (DIC)

Categories: Blood diseases, Immune diseases, Skin diseases

Aliases & Classifications for Disseminated Intravascular Coagulation

MalaCards integrated aliases for Disseminated Intravascular Coagulation:

Name: Disseminated Intravascular Coagulation 12 38 30 56 45 15 74 64
Diffuse or Disseminated Intravascular Coagulation 12
Defibrination Syndrome 12
Dic 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11247
KEGG 38 H01587
ICD9CM 36 286.6
MeSH 45 D004211
NCIt 51 C2992
SNOMED-CT 69 67406007
ICD10 34 D65
UMLS 74 C0012739

Summaries for Disseminated Intravascular Coagulation

PubMed Health : 64 About disseminated intravascular coagulation: Disseminated intravascular coagulation (ko-ag-u-LA-shun), or DIC, is a condition in which blood clots form throughout the body's small blood vessels. These blood clots can reduce or block blood flow through the blood vessels, which can damage the body's organs.In DIC, the increased clotting uses up platelets (PLATE-lets) and clotting factors in the blood. Platelets are blood cell fragments that stick together to seal small cuts and breaks on blood vessel walls and stop bleeding. Clotting factors are proteins needed for normal blood clotting.With fewer platelets and clotting factors in the blood, serious bleeding can occur. DIC can cause internal and external bleeding.Internal bleeding occurs inside the body. External bleeding occurs underneath or from the skin or mucosa. (The mucosa is the tissue that lines some organs and body cavities, such as your nose and mouth.)DIC can cause life-threatening bleeding.

MalaCards based summary : Disseminated Intravascular Coagulation, also known as diffuse or disseminated intravascular coagulation, is related to purpura fulminans and hellp syndrome. An important gene associated with Disseminated Intravascular Coagulation is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Anti-inhibitor coagulant complex and Thrombin have been mentioned in the context of this disorder. Affiliated tissues include liver, skin and prostate, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and cardiovascular system

Wikipedia : 77 Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the... more...

Related Diseases for Disseminated Intravascular Coagulation

Diseases related to Disseminated Intravascular Coagulation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 533)
# Related Disease Score Top Affiliating Genes
1 purpura fulminans 33.1 F2 F3 SERPINC1 SERPINF2
2 hellp syndrome 32.1 ADAMTS13 F2 F3 F5 SERPINC1 SERPINE1
3 thrombotic thrombocytopenic purpura 31.0 ADAMTS13 F3 THBD
4 heparin-induced thrombocytopenia 31.0 F3 SERPINC1
5 purpura 31.0 ADAMTS13 F2 F3 SERPINC1 THBD
6 placental abruption 30.9 F2 F5 SERPINC1 THBD
7 eclampsia 30.9 F2 SERPINC1 THBD
8 hemolytic-uremic syndrome 30.9 ADAMTS13 F3 THBD
9 meningococcemia 30.8 F5 SERPINC1 SERPINE1 THBD
10 endocarditis 30.7 F2 PIK3C2A PLAT SERPINC1
11 adult respiratory distress syndrome 30.7 ELANE F2 SERPINE1
12 osteonecrosis 30.7 F2 SERPINC1 SERPINE1
13 acute promyelocytic leukemia 30.7 ELANE F3 SERPINC1 SERPINF2 THBD
14 liver cirrhosis 30.6 F2 F3 SERPINC1 SERPINF2
15 protein s deficiency 30.5 F2 F3 F5 SERPINC1
16 compartment syndrome 30.5 F2 MB PIK3C2A
17 antithrombin iii deficiency 30.3 F2 F5 SERPINC1
18 respiratory failure 30.2 ELANE F3 PIK3C2A
19 giant hemangioma 30.1 F2 F3 SERPINC1 SERPINF2
20 korean hemorrhagic fever 30.1 F2 F3 SERPINC1 SERPINF2
21 blue toe syndrome 30.1 F2 F3 SERPINC1 SERPINE1
22 ischemic colitis 30.1 F2 F5 SERPINC1 SERPINE1
23 catastrophic antiphospholipid syndrome 30.0 ADAMTS13 F3 F5 SERPINE1
24 coronary thrombosis 30.0 F3 PLAT SERPINC1 SERPINE1
25 acquired hemophilia 30.0 F3 F5 F9
26 thrombophilia due to thrombin defect 29.9 F2 F3 F5 PLAT SERPINC1 SERPINE1
27 cardiac tamponade 29.9 F2 F9
28 hemophilia 29.9 F2 F3 F7 F9
29 portal vein thrombosis 29.9 F2 F5 F7 SERPINC1 SERPINE1
30 factor xiii deficiency 29.8 F3 F5 SERPINE1 SERPINF2
31 protein c deficiency 29.8 F2 F5 F9 SERPINC1 THBD
32 antiphospholipid syndrome 29.7 ADAMTS13 F2 F3 F5 PLAT SERPINC1
33 pre-eclampsia 29.7 F2 F3 F5 SERPINC1 SERPINE1 THBD
34 marantic endocarditis 29.6 F2 F3 PLAT SERPINC1 SERPINF2 THBD
35 von willebrand's disease 29.5 ADAMTS13 F2 F3 F5 F9
36 thrombosis 29.4 ADAMTS13 F2 F3 F5 F7 F9
37 acute myocardial infarction 29.4 F3 MB PIK3C2A PLAT SERPINC1 SERPINE1
38 factor x deficiency 29.4 F2 F3 F5 F7 F9 SERPINC1
39 hemophilia b 29.4 F2 F3 F7 F9 SERPINC1
40 pulmonary embolism 29.3 F2 F3 F5 F9 PLAT SERPINC1
41 thrombophlebitis 29.3 F2 F5 PLAT SERPINC1 SERPINE1 SERPINF2
42 stroke, ischemic 28.1 ADAMTS13 F2 F3 F5 F7 FGA
43 myocardial infarction 27.8 ADAMTS13 F2 F3 F5 F7 FGA
44 hemorrhagic disease 27.6 ADAMTS13 F2 F3 F5 F7 F9
45 dic in newborn 12.0
46 acute monoblastic leukemia 11.7
47 kidney cortex necrosis 11.4
48 leukemia 10.8
49 aortic aneurysm 10.6
50 gastric cancer 10.6

Comorbidity relations with Disseminated Intravascular Coagulation via Phenotypic Disease Network (PDN): (show all 15)


Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Aortic Valve Disease 1 Cardiac Arrest
Chronic Kidney Failure Decubitus Ulcer
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Mitral Valve Disease
Prostate Cancer Protein-Energy Malnutrition
Respiratory Failure

Graphical network of the top 20 diseases related to Disseminated Intravascular Coagulation:



Diseases related to Disseminated Intravascular Coagulation

Symptoms & Phenotypes for Disseminated Intravascular Coagulation

GenomeRNAi Phenotypes related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 PIK3C2A SERPINC1 SERPINE1 SERPINF2 THBD

MGI Mouse Phenotypes related to Disseminated Intravascular Coagulation:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.29 F2 F3 F5 F7 F9 FGA
2 homeostasis/metabolism MP:0005376 10.27 ADAMTS13 ELANE F2 F3 F5 F7
3 hematopoietic system MP:0005397 10.22 ADAMTS13 ELANE F2 F3 F9 FGA
4 embryo MP:0005380 10.16 F2 F3 F5 F9 FGA FN1
5 growth/size/body region MP:0005378 10.13 F2 F3 F5 F7 FN1 MB
6 immune system MP:0005387 10.1 ADAMTS13 ELANE F2 F3 F9 FGA
7 integument MP:0010771 9.86 F2 F3 F5 FGA FN1 PLAT
8 mortality/aging MP:0010768 9.83 ADAMTS13 ELANE F2 F3 F5 F7
9 liver/biliary system MP:0005370 9.7 F5 F9 FGA FN1 SERPINC1 SERPINE1
10 nervous system MP:0003631 9.23 F2 F3 F5 FGA FN1 PLAT

Drugs & Therapeutics for Disseminated Intravascular Coagulation

PubMedHealth treatment related to Disseminated Intravascular Coagulation: 64

Treatment for disseminated intravascular coagulation (DIC) depends on its severity and cause. The main goals of treating DIC are to control bleeding and clotting problems and treat the underlying cause.

Drugs for Disseminated Intravascular Coagulation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 150)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Anti-inhibitor coagulant complex Approved, Investigational Phase 4
2
Thrombin Approved, Investigational Phase 4,Not Applicable
3
Tranexamic Acid Approved Phase 4,Phase 3 1197-18-8 5526
4
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
5
Labetalol Approved Phase 4 36894-69-6 3869
6
Methyldopa Approved Phase 4 555-30-6 38853
7
Nifedipine Approved Phase 4 21829-25-4 4485
8
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
9
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Not Applicable 7440-70-2 271
10 Liver Extracts Phase 4
11 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
12 Antifibrinolytic Agents Phase 4,Phase 3
13 Factor VIII Phase 4
14 Coagulants Phase 4,Phase 3,Not Applicable
15 Hemostatics Phase 4,Phase 3,Not Applicable
16 Thromboplastin Phase 4,Not Applicable
17 Platelet Aggregation Inhibitors Phase 4
18 Prasugrel hydrochloride Phase 4 389574-19-0
19 Central Nervous System Depressants Phase 4
20 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
21 Adrenergic Agonists Phase 4,Phase 3,Not Applicable
22 Adrenergic alpha-2 Receptor Agonists Phase 4
23 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
24 Adrenergic Agents Phase 4,Phase 3,Not Applicable
25 Analgesics Phase 4,Phase 3
26 Adrenergic alpha-Agonists Phase 4,Phase 3,Not Applicable
27 Analgesics, Non-Narcotic Phase 4
28 Hypnotics and Sedatives Phase 4
29 Sympathomimetics Phase 4,Phase 3,Not Applicable
30 Autonomic Agents Phase 4,Phase 3,Not Applicable
31 Antihypertensive Agents Phase 4
32 Adrenergic alpha-Antagonists Phase 4
33 calcium channel blockers Phase 4
34 Sympatholytics Phase 4
35 Hormones Phase 4,Phase 3
36 Adrenergic alpha-1 Receptor Antagonists Phase 4
37 Adrenergic beta-Antagonists Phase 4
38 Tocolytic Agents Phase 4,Phase 3
39 Adrenergic Antagonists Phase 4
40 Vasodilator Agents Phase 4,Not Applicable
41 Anesthetics Phase 4,Not Applicable
42 Antigen-Antibody Complex Phase 4,Phase 2
43 Anticonvulsants Phase 4
44 Anti-Arrhythmia Agents Phase 4
45
Heparin Approved, Investigational Phase 3,Phase 2,Not Applicable 9005-49-6 772 46507594
46
Lenograstim Approved, Investigational Phase 2, Phase 3 135968-09-1
47
Sargramostim Approved, Investigational Phase 2, Phase 3 123774-72-1, 83869-56-1
48
Racepinephrine Approved Phase 3,Not Applicable 329-65-7 838
49
Epinephrine Approved, Vet_approved Phase 3,Not Applicable 51-43-4 5816
50
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743

Interventional clinical trials:

(show top 50) (show all 68)
# Name Status NCT ID Phase Drugs
1 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
2 Clinical Pharmacokinetics Study of ART-123 in Disseminated Intravascular Coagulation (DIC) Subjects With Renal Impairment Completed NCT01704001 Phase 4 ART-123
3 A Comparison Study of Bypassing Agent Therapy With and Without Tranexamic Acid in Haemophilia A Patients With Inhibitor Completed NCT01800435 Phase 4 aPCC, aPCC + TXA;rFVIIa, rFVIIa + TXA
4 The Role of the P2Y12 Receptor in Tissue Factor Induced Coagulation Completed NCT01099566 Phase 4 Prasugrel;Placebo
5 Dexmedetomidine for Sepsis in ICU Randomized Evaluation Trial Completed NCT01760967 Phase 4 Dexmedetomidine
6 Early Vascular Adjustments During Hypertensive Pregnancy Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
7 Prevention of Postpartum Hemorrhage With TXA Recruiting NCT03326596 Phase 4 Tranexamic Acid 1000 mg/10ml normal saline infusion
8 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
9 Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock Trial. VIPER-Sepsis (EudraCT no. 2016-000707-81) Terminated NCT02875236 Phase 4 OctaplasLG®;Ringer-acetat
10 Efficacy and Safety of Unfractionated Heparin on Severe Sepsis With Suspected Disseminated Intravascular Coagulation Unknown status NCT02654561 Phase 3 Heparin Sodium;Saline
11 The Effect of Ulinastatin on Bronchoalveolar Lavage Fluid of Inflammatory Factors in Patients With Ventilator-associated Pneumonia Unknown status NCT01865266 Phase 2, Phase 3 Ulinaststin for injection;placebo
12 An Open-label Study of KW-3357 Completed NCT01384903 Phase 3 KW-3357;Plasma-derived antithrombin
13 A Clinical Study of KW-3357 in Patients With DIC Completed NCT01384396 Phase 3 KW-3357
14 Impact of Low Dose Unfractionated Heparin Treatment on Inflammation in Sepsis Completed NCT02135770 Phase 3 Unfractionated heparin
15 Heparin Binding Protein in Patients With Acute Respiratory Failure Treated With GCSF (Filgrastim) Completed NCT01713309 Phase 2, Phase 3 Filgrastim
16 Comparison of Topical and Intravenous Tranexamic Acid in Total Hip Arthroplasty Completed NCT02312440 Phase 3 0.9% sodium chloride;tranexamic acid;tranexamic acid
17 Comparison of Topical Versus Intravenous Tranexamic Acid in TKA Completed NCT02393300 Phase 3 normal saline;Tranexamic Acid;Tranexamic Acid
18 Bronchiolitis in Infants Placebo Versus Dexamethasone Study Recruiting NCT03567473 Phase 3 Oral dexamethasone;Nebulized Epinephrine;Oral placebo;Nebulized normal saline
19 Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic Leukemia Recruiting NCT02339740 Phase 3 Arsenic Trioxide;Cytarabine;Dexamethasone;Idarubicin;Mitoxantrone Hydrochloride;Tretinoin
20 A Phase 3 Clinical Study of KW-3357 in Patients With DIC Terminated NCT01384409 Phase 3 KW-3357
21 A Phase III Efficacy and Safety Study of Intravenous Retosiban Versus Placebo for Women in Spontaneous Preterm Labor Terminated NCT02377466 Phase 3 Retosiban IV infusion;Placebo IV infusion
22 A Randomized Study Comparing the Efficacy and Safety of Retosiban Versus Atosiban for Women in Spontaneous Preterm Labour Terminated NCT02292771 Phase 3 Retosiban;Atosiban;Placebo matching retosiban;Placebo matching atosiban
23 Safety and Efficacy of ART-123 in Subjects With Sepsis and Disseminated Intravascular Coagulation Completed NCT00487656 Phase 2 ART-123;placebo
24 GR270773 In The Treatment Of Suspected Or Confirmed Gram-Negative Severe Sepsis In Adults Completed NCT00089986 Phase 2 Intravenous GR270773- Phospholipid Emulsion
25 Recombinant Vaccinia Virus Administered Intravenously in Patients With Metastatic, Refractory Colorectal Carcinoma Completed NCT01394939 Phase 1, Phase 2 Irinotecan
26 Safety and Efficacy of the ONCOlytic VIRus Armed for Local Chemotherapy, TG6002/5-FC, in Recurrent Glioblastoma Patients Recruiting NCT03294486 Phase 1, Phase 2 Combination of TG6002 and 5-flucytosine (5-FC, Ancotil®)
27 Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock (SHOCK) Trial Recruiting NCT03092245 Phase 2 OctaplasLG;Ringer-Acetate
28 Recombinant Human Antithrombin (ATryn®) in the Treatment of Patients With DIC Associated With Severe Sepsis Terminated NCT00506519 Phase 2 antithrombin alfa (INN name)
29 4G/5G Polymorphism of Plasminogen Activator Inhibitor-1 Gene and Disseminated Intravascular Coagulation in Severe Sepsis and Septic Shock Unknown status NCT01211899
30 Interest of the Balance of Pro-coagulating and Profibrinolytis Activities of the Microparticles (MP) in the Prognosis of Septic Shock Unknown status NCT02062970 Not Applicable
31 Oxidative Stress and Endothelial Function in Pregnancy Complications Unknown status NCT02603913
32 IMproved PRegnancy Outcome by Early Detection Unknown status NCT01891240
33 Coagulation Factor Changes Associated With Postpartum Hysterectomies Completed NCT00456547
34 Role of the Circulating Procoagulants Microparticles in the Hypercoagulability of MNP Ph1- Completed NCT02862366
35 Study of New Biological Markers for Prediction of Severe Acute Pancreatitis Completed NCT00786591
36 TC-325 (HEMOSPRAY™) VS. CURRENT STANDARD OF CARE IN MANAGING MALIGNANT GASTROINTESTINAL BLEEDING: A PILOT STUDY TO INFORM A RANDOMIZED CONTROLLED TRIAL. Completed NCT02135627 Not Applicable TC-325 monotherapy on initial endoscopy ± radiation therapy, angioembolization, and/or surgery.
37 Correlation Between Cytokines and the Severity of Meningococcal Disease Completed NCT01133834
38 Platelet Reactivity in Septic Shock Completed NCT03716310
39 The Use of the Bakri Postpartum Balloon in the Management of Postpartum Hemorrhage Refractory to Conservative Measures Completed NCT01844089
40 Impact of Monitoring Quality Indicators in Maternity Departments on Mother and Infant Health Completed NCT01459978
41 The Procalcitonin and Survival Study Completed NCT00271752 Not Applicable
42 Retrospective Longitudinal Study of Gestational Weight Gain Among Chinese Pregnant Women Completed NCT03154268
43 International Prospective Registry of Disseminated Intravascular Coagulation Recruiting NCT03577015
44 Thromboelastometry Guided DIC Prevention After Cesarean Section in Pregnant Women With Placenta Previa Recruiting NCT03266432 Not Applicable
45 Rotational Thromboelastometry for the Transfusion Management of Postpartum Hemorrhage After Vaginal or Cesarean Delivery Recruiting NCT03064152 Not Applicable
46 Evaluation of Endothelial Dysfunction During Aortic Valvular Replacement by Bioprosthesis With and Without Extracorporeal Circulation Recruiting NCT03135496
47 Hypercoagulation Screening in Cancer Recruiting NCT02622815
48 Randomizated Open-label Control Trial to Evaluate if the Incorporation of sFlt1/PlGF Ratio in the Diagnosis and Classification of PE Improves Maternal and Perinatal Outcomes in Women With the Suspicion of the Disease Recruiting NCT03231657 Not Applicable
49 Patient Blood Management for Massive Obstetric Hemorrhage Recruiting NCT03784794 Not Applicable Fibrinogen Concentrate Human;Prothrombin Complex Concentrates
50 Esomeprazole With Sildenafil Citrate in Women With Early-onset Preeclampsia Recruiting NCT03724838 Not Applicable Esomeprazole with Sildenafil Citrate;Sildenafil Citrate;Placebo to Esomeprazole;Placebo to Sildenafil Citrate

Search NIH Clinical Center for Disseminated Intravascular Coagulation

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: disseminated intravascular coagulation

Genetic Tests for Disseminated Intravascular Coagulation

Genetic tests related to Disseminated Intravascular Coagulation:

# Genetic test Affiliating Genes
1 Disseminated Intravascular Coagulation 30

Anatomical Context for Disseminated Intravascular Coagulation

MalaCards organs/tissues related to Disseminated Intravascular Coagulation:

42
Liver, Skin, Prostate, Endothelial, Testes, Bone, Placenta

Publications for Disseminated Intravascular Coagulation

Articles related to Disseminated Intravascular Coagulation:

(show top 50) (show all 2557)
# Title Authors Year
1
A case of recurrent angiosarcoma with isolated bone marrow metastasis presented as acute disseminated intravascular coagulation. ( 30887676 )
2019
2
Successful surgical management of non-perforating acute appendicitis with septic disseminated intravascular coagulation: A case report and review of the literature. ( 30716702 )
2019
3
Multicenter clinical experience with recombinant soluble thrombomodulin for disseminated intravascular coagulation associated with severe acute cholecystitis. ( 30780007 )
2019
4
Predicting mortality in patients with disseminated intravascular coagulation after cardiopulmonary bypass surgery by utilizing two scoring systems. ( 30431447 )
2019
5
Evaluation the combined diagnostic value of TAT, PIC, tPAIC, and sTM in disseminated intravascular coagulation: A multi-center prospective observational study. ( 30458338 )
2019
6
The prognosis of disseminated intravascular coagulation associated with hematologic malignancy and its response to recombinant human thrombomodulin. ( 30472436 )
2019
7
A multicenter, prospective evaluation of the Chinese Society of Thrombosis and Hemostasis Scoring System for disseminated intravascular coagulation. ( 30529391 )
2019
8
Comparison of gabexate mesilate and nafamostat mesilate for disseminated intravascular coagulation associated with hematological malignancies. ( 30536180 )
2019
9
Twin pregnancy complicated by disseminated intravascular coagulation following single fetal demise. ( 30573227 )
2019
10
Anticoagulant Therapy for Disseminated Intravascular Coagulation After Gastrointestinal Surgery. ( 30591437 )
2019
11
Differential diagnoses for sepsis-induced disseminated intravascular coagulation: communication from the SSC of the ISTH. ( 30618150 )
2019
12
The Elusive Diagnosis of Disseminated Intravascular Coagulation: Does a Diagnosis of DIC Exist Anymore? ( 30634199 )
2019
13
Successful treatment for disseminated intravascular coagulation (DIC) corresponding to phenotype changes in a heat stroke patient. ( 30675362 )
2019
14
Repeat dose exposure of PM2.5 triggers the disseminated intravascular coagulation (DIC) in SD rats. ( 30711591 )
2019
15
Changes in Mannose-Binding Lectin and Collectin Kidney 1 Levels in Sepsis Patients With and Without Disseminated Intravascular Coagulation. ( 30808212 )
2019
16
Usefulness of Measuring Changes in SOFA Score for the Prediction of 28-Day Mortality in Patients With Sepsis-Associated Disseminated Intravascular Coagulation. ( 30808223 )
2019
17
Impact of Antithrombin Supplementation and Concomitant Anticoagulation Therapy in Pediatric Patients With Disseminated Intravascular Coagulation. ( 30836769 )
2019
18
Optimal Timing and Early Intervention With Anticoagulant Therapy for Sepsis-Induced Disseminated Intravascular Coagulation. ( 30841721 )
2019
19
Four-extremity amputation following disseminated intravascular coagulation and purpura fulminans. ( 30898966 )
2019
20
Biomarkers of disseminated intravascular coagulation in pediatric intensive care unit in Thailand. ( 30208259 )
2019
21
Risk factors for disseminated intravascular coagulation in patients with lung cancer. ( 29851300 )
2018
22
Prediction of Disseminated Intravascular Coagulation by Liver Function Tests in Patients with Japanese Spotted Fever. ( 29021432 )
2018
23
Clinical characteristics of disseminated intravascular coagulation in patients with solid and hematological cancers. ( 29703488 )
2018
24
Management of disseminated intravascular coagulation: current insights on antithrombin and thrombomodulin treatments. ( 29343993 )
2018
25
Genistein has the function of alleviating and treating disseminated intravascular coagulation caused by lipopolysaccharide. ( 29761425 )
2018
26
Screening itself for disseminated intravascular coagulation may reduce mortality in sepsis: A nationwide multicenter registry in Japan. ( 29202320 )
2018
27
Enterohemorrhagic colitis with disseminated intravascular coagulation. ( 29904297 )
2018
28
How I treat disseminated intravascular coagulation. ( 29255070 )
2018
29
<i>ALK</i>-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation. ( 29850298 )
2018
30
Newly Proposed Sepsis-Induced Coagulopathy Precedes International Society on Thrombosis and Haemostasis Overt-Disseminated Intravascular Coagulation and Predicts High Mortality. ( 29720054 )
2018
31
Pathogenesis and diagnosis of disseminated intravascular coagulation. ( 29741245 )
2018
32
Thrombotic and hemorrhagic complications during visceral transplantation: risk factors, and association with intraoperative disseminated intravascular coagulation-like thromboelastographic qualities: a single-center retrospective study. ( 29786890 )
2018
33
Bilateral orbital compartment syndrome in a patient with disseminated intravascular coagulation. ( 29308942 )
2018
34
International Normalized Ratio Relevance to the Observed Coagulation Abnormalities in Warfarin Treatment and Disseminated Intravascular Coagulation. ( 29848060 )
2018
35
Clinical Impact of Recombinant Soluble Thrombomodulin for Disseminated Intravascular Coagulation Associated with Severe Acute Cholangitis. ( 29699063 )
2018
36
Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways. ( 29921614 )
2018
37
Machine learning-based diagnosis for disseminated intravascular coagulation (DIC): Development, external validation, and comparison to scoring systems. ( 29718941 )
2018
38
A rare variant of t(17;19) in a case of Philadelphia positive adult acute lymphoblastic leukemia presenting with disseminated intravascular coagulation. ( 29662872 )
2018
39
Antithrombin concentrate use in disseminated intravascular coagulation of sepsis: meta-analyses revisited. ( 29316235 )
2018
40
Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies-what intensivists need to know. ( 29895296 )
2018
41
Recombinant Thrombomodulin Used to Successfully Treat Cronkhite-Canada Syndrome with Disseminated Intravascular Coagulation due to Sepsis in a Compromised Patient: A Case Report. ( 29877275 )
2018
42
The disseminated intravascular coagulation score is a novel predictor for portal vein thrombosis in cirrhotic patients with hepatitis B. ( 29178991 )
2018
43
A summary of the Japan septic disseminated intravascular coagulation study. ( 29657722 )
2018
44
No impact of disseminated intravascular coagulation in kidney donors on long-term kidney transplantation outcome: A multicenter propensity-matched study. ( 29981217 )
2018
45
Successful management of obstetric disseminated intravascular coagulation using a portable fibrinogen-measuring device. ( 29359377 )
2018
46
Disseminated intravascular coagulation: is it fact or fancy? ( 29621007 )
2018
47
Antithrombin concentrate use in sepsis-associated disseminated intravascular coagulation: re-evaluation of a 'pendulum effect' drug using a nationwide database. ( 29316251 )
2018
48
Evaluation of disseminated intravascular coagulation scores in critically ill pediatric patients with septic shock. ( 29940405 )
2018
49
Delayed disseminated intravascular coagulation revealed by spontaneous hematomas after conservative treatment of placenta percreta. ( 29804883 )
2018
50
Impact of non-anticoagulant therapy on patients with sepsis-induced disseminated intravascular coagulation: A multicenter, case-control study. ( 29329022 )
2018

Variations for Disseminated Intravascular Coagulation

Expression for Disseminated Intravascular Coagulation

Search GEO for disease gene expression data for Disseminated Intravascular Coagulation.

Pathways for Disseminated Intravascular Coagulation

Pathways related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.01 F2 F3 F5 F7 F9 FGA
2
Show member pathways
12.58 F2 F3 F5 F7 F9 FGA
3
Show member pathways
12.13 F2 F7 PLAT SERPINE1
4 11.84 F2 F3 F5 F7 F9 FGA
5
Show member pathways
11.82 F2 FN1 PLAT
6
Show member pathways
11.75 F2 F7 F9
7 11.73 FN1 PLAT SERPINE1
8 11.71 F3 FN1 SERPINE1 THBD
9
Show member pathways
11.68 F2 FGA FN1
10
Show member pathways
11.57 F2 F3 F5 F7 F9 FGA
11 11.44 FN1 PLAT SERPINE1
12 11.32 FGA FN1 PLAT
13 11.29 ELANE FN1 PLAT
14 10.72 F2 F7 F9
15 10.61 PLAT SERPINE1 SERPINF2

GO Terms for Disseminated Intravascular Coagulation

Cellular components related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.83 F2 FGA FN1 SERPINC1 SERPINF2
2 endoplasmic reticulum lumen GO:0005788 9.76 ADAMTS13 F2 F5 F7 F9 FGA
3 platelet alpha granule lumen GO:0031093 9.72 F5 FGA FN1 SERPINE1 SERPINF2
4 Golgi lumen GO:0005796 9.67 F2 F7 F9
5 fibrinogen complex GO:0005577 9.58 FGA FN1 SERPINF2
6 collagen-containing extracellular matrix GO:0062023 9.56 ELANE F3 FGA FN1 PLAT SERPINC1
7 platelet alpha granule GO:0031091 9.51 F5 FGA
8 serine-type peptidase complex GO:1905286 9.48 F3 F7
9 extracellular space GO:0005615 9.47 ADAMTS13 ELANE F2 F3 F5 F7
10 extracellular exosome GO:0070062 10.11 ELANE F2 F9 FGA FN1 MB
11 extracellular region GO:0005576 10.07 ADAMTS13 ELANE F2 F3 F5 F7
12 cell surface GO:0009986 10 ADAMTS13 ELANE F3 FGA PLAT SERPINF2

Biological processes related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.99 ADAMTS13 ELANE F2 F7 F9 PLAT
2 post-translational protein modification GO:0043687 9.92 F5 FGA FN1 SERPINC1
3 ER to Golgi vesicle-mediated transport GO:0006888 9.84 F2 F5 F7 F9
4 negative regulation of endopeptidase activity GO:0010951 9.81 SERPINC1 SERPINE1 SERPINF2
5 negative regulation of peptidase activity GO:0010466 9.8 SERPINC1 SERPINE1 SERPINF2
6 cellular protein metabolic process GO:0044267 9.8 F2 F5 FGA FN1 SERPINC1
7 platelet activation GO:0030168 9.79 ADAMTS13 F2 FGA
8 cell-matrix adhesion GO:0007160 9.77 ADAMTS13 FGA FN1
9 platelet degranulation GO:0002576 9.72 F5 FGA FN1 SERPINE1 SERPINF2
10 protein processing GO:0016485 9.7 ADAMTS13 F3 F7
11 blood coagulation GO:0007596 9.65 ADAMTS13 F2 F3 F5 F7 F9
12 negative regulation of proteolysis GO:0045861 9.64 F2 PLAT
13 positive regulation of collagen biosynthetic process GO:0032967 9.64 F2 SERPINF2
14 blood coagulation, intrinsic pathway GO:0007597 9.62 F2 F9
15 negative regulation of blood coagulation GO:0030195 9.61 SERPINE1 THBD
16 acute-phase response GO:0006953 9.61 F2 FN1 SERPINF2
17 regulation of blood coagulation GO:0030193 9.6 F2 SERPINC1
18 positive regulation of positive chemotaxis GO:0050927 9.58 F3 F7
19 plasminogen activation GO:0031639 9.58 FGA PLAT
20 negative regulation of platelet activation GO:0010544 9.57 F2 THBD
21 acute inflammatory response to antigenic stimulus GO:0002438 9.56 ELANE SERPINC1
22 negative regulation of fibrinolysis GO:0051918 9.56 F2 SERPINE1 SERPINF2 THBD
23 negative regulation of plasminogen activation GO:0010757 9.55 SERPINE1 SERPINF2
24 fibrinolysis GO:0042730 9.55 F2 FGA PLAT SERPINE1 SERPINF2
25 positive regulation of blood coagulation GO:0030194 9.54 F2 F7 SERPINE1
26 blood coagulation, extrinsic pathway GO:0007598 9.49 F3 F7
27 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.48 F3 F7
28 neutrophil mediated killing of gram-negative bacterium GO:0070945 9.46 ELANE F2
29 hemostasis GO:0007599 9.28 ADAMTS13 F2 F3 F5 F7 F9

Molecular functions related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.88 ADAMTS13 F2 F7 F9 THBD
2 peptidase activity GO:0008233 9.8 ADAMTS13 ELANE F2 F7 F9 PLAT
3 signaling receptor binding GO:0005102 9.73 F2 F7 FGA FN1 PLAT SERPINE1
4 peptidase inhibitor activity GO:0030414 9.67 SERPINC1 SERPINE1 SERPINF2
5 heparin binding GO:0008201 9.67 ELANE F2 FN1 SERPINC1
6 serine-type endopeptidase inhibitor activity GO:0004867 9.61 SERPINC1 SERPINE1 SERPINF2
7 endopeptidase activity GO:0004175 9.58 ELANE F7 F9
8 serine-type peptidase activity GO:0008236 9.55 ELANE F2 F7 F9 PLAT
9 serine-type endopeptidase activity GO:0004252 9.43 ELANE F2 F3 F7 F9 PLAT
10 protease binding GO:0002020 9.1 ELANE F3 FN1 SERPINC1 SERPINE1 SERPINF2
11 protein binding GO:0005515 10.3 ADAMTS13 ELANE F2 F3 F5 F7

Sources for Disseminated Intravascular Coagulation

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
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