Disseminated Intravascular Coagulation (DIC)

Categories: Blood diseases, Immune diseases, Skin diseases

Aliases & Classifications for Disseminated Intravascular Coagulation

MalaCards integrated aliases for Disseminated Intravascular Coagulation:

Name: Disseminated Intravascular Coagulation 12 36 29 54 44 15 62 70
Diffuse or Disseminated Intravascular Coagulation 12
Defibrination Syndrome 12
Dic 12


External Ids:

Disease Ontology 12 DOID:11247
KEGG 36 H01587
ICD9CM 34 286.6
MeSH 44 D004211
NCIt 50 C2992
SNOMED-CT 67 67406007
ICD10 32 D65
UMLS 70 C0012739

Summaries for Disseminated Intravascular Coagulation

PubMed Health : 62 About disseminated intravascular coagulation: Disseminated intravascular coagulation (ko-ag-u-LA-shun), or DIC, is a condition in which blood clots form throughout the body's small blood vessels. These blood clots can reduce or block blood flow through the blood vessels, which can damage the body's organs. In DIC, the increased clotting uses up platelets (PLATE-lets) and clotting factors in the blood. Platelets are blood cell fragments that stick together to seal small cuts and breaks on blood vessel walls and stop bleeding. Clotting factors are proteins needed for normal blood clotting. With fewer platelets and clotting factors in the blood, serious bleeding can occur. DIC can cause internal and external bleeding. Internal bleeding occurs inside the body. External bleeding occurs underneath or from the skin or mucosa. (The mucosa is the tissue that lines some organs and body cavities, such as your nose and mouth.) DIC can cause life-threatening bleeding.

MalaCards based summary : Disseminated Intravascular Coagulation, also known as diffuse or disseminated intravascular coagulation, is related to protein c deficiency and purpura fulminans. An important gene associated with Disseminated Intravascular Coagulation is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Heparin and Serine Proteinase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and bone marrow, and related phenotypes are Decreased viability and Decreased viability

KEGG : 36 Disseminated intravascular coagulation (DIC) is an acquired syndrome characterised by the intravascular activation of coagulation with loss of localisation arising from different causes. It can originate from and cause damage to the microvasculature, which if sufficiently severe, can produce organ dysfunction. DIC is not a disease entity on itself but is always associated to an underlying disease. The clinical conditions that may be associated with DIC include sepsis, trauma, malignancy, liver disease, obstetric disorders, envenomation, vascular anomalies, and major transfusion reactions. A diagnosis of DIC should be made only in the presence of a clinical condition (causative factor) supported by repeated laboratory tests for coagulation profile and clotting factors. Treatment of DIC is aimed at combating the underlying disorder followed by supportive management.

Wikipedia : 73 Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the... more...

Related Diseases for Disseminated Intravascular Coagulation

Diseases related to Disseminated Intravascular Coagulation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 969)
# Related Disease Score Top Affiliating Genes
1 protein c deficiency 32.1 THBD SERPINE1 SERPINC1 F9 F5 F2
2 purpura fulminans 32.1 THBD SERPINF2 SERPINC1 F5 F3 F2
3 hellp syndrome 31.9 THBD SERPINE1 SERPINC1 PLAT IL6 F5
4 toxic shock syndrome 31.8 SERPINC1 IL6 F3
5 dic in newborn 31.8 SERPINF2 SERPINE1 SERPINC1 F7 F3 F2
6 placental abruption 31.7 THBD SERPINC1 F5 F2
7 eclampsia 31.7 THBD SERPINC1 F2
8 purpura 31.6 THBD SERPINC1 IL6 F3 F2 ADAMTS13
9 thrombotic microangiopathy 31.6 THBD F3 ADAMTS13
10 acute kidney failure 31.6 PIK3C2A MB F2 ADAMTS13
11 meningococcemia 31.4 THBD SERPINE1 SERPINC1 F5
12 hemolytic-uremic syndrome 31.2 THBD PLG F3 F2 ADAMTS13
13 exanthem 31.2 PIK3C2A IL6 F3 F2
14 aortic aneurysm, familial abdominal, 1 31.2 SERPINE1 SERPINC1 PLG IL6 ELANE
15 infective endocarditis 31.2 SERPINE1 IL6 F2
16 pulmonary edema 31.2 SERPINC1 PIK3C2A F2
17 heparin-induced thrombocytopenia 31.2 SERPINC1 F3 F10
18 cardiogenic shock 31.2 PLAT IL6
19 waterhouse-friderichsen syndrome 31.1 SERPINC1 F3 F2
20 endocarditis 31.1 SERPINE1 SERPINC1 PLAT PIK3C2A IL6 F2
21 peritonitis 31.1 IL6 F2 ELANE
22 adult respiratory distress syndrome 31.1 THBD SERPINE1 PLG IL6 F5 F2
23 acute cholangitis 31.1 THBD IL6 F2
24 cholangitis 31.1 IL6 F3 F2
25 esophageal varix 31.0 SERPINC1 F3 F2
26 kidney cortex necrosis 30.9 PLG F2 ADAMTS13
27 respiratory failure 30.9 THBD PIK3C2A IL6 FGA F3 F2
28 osteonecrosis 30.9 SERPINE1 SERPINC1 PLG F2
29 typhoid fever 30.9 THBD IL6 F2
30 intracranial hypotension 30.8 SERPINC1 F3 F2
31 mediastinitis 30.8 F5 F3 F2
32 splenic infarction 30.8 SERPINC1 F3 F2
33 acute kidney tubular necrosis 30.8 PIK3C2A MB IL6 F2
34 syphilis 30.8 IL6 FN1 F2
35 severe pre-eclampsia 30.8 SERPINC1 FN1 F5
36 portal hypertension 30.8 F3 F2 ADAMTS13
37 leptospirosis 30.8 PIK3C2A IL6 F2
38 post-cardiac arrest syndrome 30.8 THBD PPIC IL6
39 anuria 30.8 PIK3C2A MB F3 F2 ADAMTS13
40 hemoglobinuria 30.8 THBD SERPINC1 MB F2
41 cellulitis 30.8 IL6 F3 F2
42 nephrosclerosis 30.8 F3 F2 ADAMTS13
43 pericardial effusion 30.7 PIK3C2A IL6 F3 F2
44 dengue hemorrhagic fever 30.7 IL6 F3 F2
45 liver cirrhosis 30.7 SERPINF2 SERPINC1 IL6 F3 F2 ADAMTS13
46 thrombotic thrombocytopenic purpura 30.7 THBD SERPINF2 SERPINC1 PLAT F3 ADAMTS13
47 ischemic colitis 30.7 SERPINE1 SERPINC1 F5 F2
48 nonbacterial thrombotic endocarditis 30.7 SERPINC1 PLG IL6 F3 F2 ADAMTS13
49 thrombocytosis 30.7 SERPINC1 IL6 FGA F3 F2
50 aplastic anemia 30.7 THBD SERPINE1 SERPINC1 IL6 FN1

Comorbidity relations with Disseminated Intravascular Coagulation via Phenotypic Disease Network (PDN): (show all 15)

Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Aortic Valve Disease 1 Cardiac Arrest
Chronic Kidney Disease Decubitus Ulcer
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Mitral Valve Disease
Prostate Cancer Protein-Energy Malnutrition
Respiratory Failure

Graphical network of the top 20 diseases related to Disseminated Intravascular Coagulation:

Diseases related to Disseminated Intravascular Coagulation

Symptoms & Phenotypes for Disseminated Intravascular Coagulation

GenomeRNAi Phenotypes related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.66 PIK3C2A
2 Decreased viability GR00055-A-2 9.66 PIK3C2A
3 Decreased viability GR00055-A-3 9.66 PIK3C2A
4 Decreased viability GR00221-A-1 9.66 PIK3C2A
5 Decreased viability GR00221-A-2 9.66 PIK3C2A
6 Decreased viability GR00221-A-4 9.66 PIK3C2A
7 Decreased viability GR00240-S-1 9.66 PIK3C2A
8 Decreased viability GR00249-S 9.66 F10 F5 F7 PIK3C2A SERPINE1
9 Decreased viability GR00342-S-1 9.66 PIK3C2A
10 Decreased viability GR00342-S-2 9.66 PIK3C2A
11 Decreased viability GR00342-S-3 9.66 PIK3C2A
12 Decreased viability GR00381-A-1 9.66 PLAT SERPINF2
13 Decreased viability GR00381-A-2 9.66 SERPINF2
14 Decreased viability GR00386-A-1 9.66 FGA MB PPIC
15 Decreased viability GR00402-S-2 9.66 FGA

MGI Mouse Phenotypes related to Disseminated Intravascular Coagulation:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.41 F10 F2 F3 F5 F7 F9
2 homeostasis/metabolism MP:0005376 10.38 ADAMTS13 ELANE F10 F2 F3 F5
3 hematopoietic system MP:0005397 10.28 ADAMTS13 ELANE F3 F9 FGA FN1
4 growth/size/body region MP:0005378 10.27 F2 F3 F5 F7 FN1 IL6
5 cellular MP:0005384 10.24 F2 F3 FGA FN1 IL6 MB
6 immune system MP:0005387 10.21 ADAMTS13 ELANE F2 F3 F9 FGA
7 embryo MP:0005380 10.18 F2 F3 F5 F9 FGA FN1
8 mortality/aging MP:0010768 10.11 ADAMTS13 ELANE F10 F2 F3 F5
9 integument MP:0010771 10.06 ELANE F2 F3 F5 FGA FN1
10 liver/biliary system MP:0005370 9.91 F5 F9 FGA FN1 IL6 PLG
11 nervous system MP:0003631 9.73 F2 F3 F5 FGA FN1 IL6
12 respiratory system MP:0005388 9.23 F2 F3 IL6 MB PLAT PLG

Drugs & Therapeutics for Disseminated Intravascular Coagulation

PubMed Health treatment related to Disseminated Intravascular Coagulation: 62

Treatment for disseminated intravascular coagulation (DIC) depends on its severity and cause. The main goals of treating DIC are to control bleeding and clotting problems and treat the underlying cause.

Drugs for Disseminated Intravascular Coagulation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Heparin Approved, Investigational Phase 3 9005-49-6 772 9812414
2 Serine Proteinase Inhibitors Phase 3
3 Antithrombin III Phase 3
protease inhibitors Phase 3
5 Antithrombins Phase 3
6 HIV Protease Inhibitors Phase 3
7 Anticoagulants Phase 3
8 Pharmaceutical Solutions Phase 3
9 calcium heparin Phase 3
10 Calcium, Dietary Phase 3
Serine Investigational, Nutraceutical Phase 3 56-45-1 5951
Calcium Nutraceutical Phase 3 7440-70-2 271
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
15 Nutrients Phase 2
16 Trace Elements Phase 2
17 Micronutrients Phase 2
18 Vitamins Phase 2
19 Fibrinolytic Agents Phase 2
20 Cyclooxygenase Inhibitors Phase 2
21 Analgesics, Non-Narcotic Phase 2
22 Analgesics Phase 2
23 Antirheumatic Agents Phase 2
24 Anti-Inflammatory Agents Phase 2
25 Calciferol Phase 2
26 Antipyretics Phase 2
27 Anti-Inflammatory Agents, Non-Steroidal Phase 2
28 Platelet Aggregation Inhibitors Phase 2
Protein C Approved
Vitamin K1 Approved, Investigational 84-80-0 5284607
Sodium citrate Approved, Investigational 68-04-2
Dalteparin Approved 9005-49-6
Adenosine Approved, Investigational 58-61-7 60961
Tinzaparin Approved 9041-08-1, 9005-49-6 25244225
Thrombin Approved, Investigational
Menadione Approved, Nutraceutical 58-27-5 4055
Citric acid Approved, Nutraceutical, Vet_approved 77-92-9 311
38 Menaquinone Investigational 1182-68-9
arachidonic acid Experimental 506-32-1 444899
40 Plasminogen
41 Plasminogen Activator Inhibitor 1
42 Plasminogen Inactivators
43 Vitamin K 1
44 Vitamin K
45 Antifibrinolytic Agents
46 naphthoquinone
47 Citrate
48 Heparin, Low-Molecular-Weight
49 Thromboplastin
50 Coagulants

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 A Post-Marketing Clinical Pharmacokinetics Study of ART-123 in DIC Subjects With Renal Impairment Completed NCT01704001 Phase 4 ART-123
2 An Open-label Study of KW-3357 Compared to Plasma-derived Antithrombin for Disseminated Intravascular Coagulation (DIC) Associated With Infection Completed NCT01384903 Phase 3 KW-3357;Plasma-derived antithrombin
3 A Clinical Study of KW-3357 in Patients Diagnosed as Disseminated Intravascular Coagulation (DIC) by the Diagnostic Criteria for DIC Established by the Japanese Ministry of Health and Welfare Completed NCT01384396 Phase 3 KW-3357
4 Phase 3 Study of the Efficacy and Safety of Unfractionated Heparin in Patients With Severe Sepsis/Septic Shock With Suspected DIC Recruiting NCT02654561 Phase 3 Heparin Sodium;Saline
5 A Clinical Study of KW-3357 in Patients Diagnosed as Disseminated Intravascular Coagulation (DIC) by Japanese Association for Acute Medicine-defined DIC Criteria Terminated NCT01384409 Phase 3 KW-3357
6 A Randomized, Double-Blind, Placebo-Controlled, Phase-2B Study to Assess the Safety and Efficacy Effects of ART-123 on Subjects With Sepsis and Disseminated Intravascular Coagulation Completed NCT00487656 Phase 2 ART-123;placebo
7 The LEAD COVID-19 Trial: Low-risk, Early Aspirin and Vitamin D to Reduce COVID-19 Hospitalizations Not yet recruiting NCT04363840 Phase 2 Aspirin 81 mg
8 Exploratory Efficacy and Safety, Pharmacokinetics and Dose Finding Study of ATryn® (Antithrombin Alfa) in Patients With Disseminated Intravascular Coagulation Associated With Severe Sepsis Terminated NCT00506519 Phase 2 antithrombin alfa (INN name)
9 Incidence and Prognosis of Disseminated Intravscular Coagulation in Patients Severe Sepsis and Septic Shock; Association With 4G/5G Polymorphism of PAI-1 Gene Unknown status NCT01211899
10 Coagulation Assays in the Critically Ill Patient: a New Approach Using the Thrombomodulin-modified Thrombin Generation Assay (TGA-TM) Completed NCT04356144
11 Effect of Vitamin K in Critically Ill Patients With Spontaneously Increased Pro-thrombin Time Measured With Routine Coagulation Tests and Advanced Coagulation- and Vitamin K-assays Completed NCT03782025 Phytomenadione
12 Impaired Platelet Reactivity as an Early Biomarker for Sepsis-related Thrombocytopenia Completed NCT03716310
13 International Prospective Registry for the Diagnosis and Management of Disseminated Intravascular Coagulation in the Intensive Care Unit Recruiting NCT03577015
14 Rotational Thromboelastometry Versus The Disseminated Intravascular Coagulation Score in Sepsis (RODSS) Recruiting NCT04610853
15 Waveform Analysis In Snakebite Victims With Hematotoxicity Recruiting NCT03859154
16 ROTEM Guided and Hemostatic Drugs Algorithms vs Standard Coagulation Test and Hemocomponent for Massive Obstetric Hemorrhage Recruiting NCT03784794 Fibrinogen Concentrate Human;Prothrombin Complex Concentrates
17 International Observational Study on BLood Management for Mechanical Circulatory Support Using Extracorporeal Membrane Oxygenation (OBLEX) Recruiting NCT03714048
18 Prospective Evaluation of PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock Patients. Impact of Platelets Metabolism to Inflammatory Response. Recruiting NCT04107402
19 Thromboelastometry Guided Disseminated Intravascular Coagulation Prevention After Cesarean Section in Pregnant Women With Placenta Previa Recruiting NCT03266432
20 Prospective Randomized Versus Placebo Study Assessing Efficacy of Plasmatherapy in Septic Shock-induced Coagulopathy: Feasibility Study Active, not recruiting NCT04580563 OctaplasLG®;0.9% NaCl
21 Analysis of the Coagulopathy Developed by COVID-19 Infected Patients: Thrombin Generation Potential in COVID-19 Infected Patients Active, not recruiting NCT04356950
22 Exploratory Assessment of the Coagulation Changes Associated With Severe Inflammation in COVID-19 Patients Enrolling by invitation NCT04460664
23 Haemostatic Variables in Snakebite: a Regional Prospective Cohort to Identify the Role of Global Coagulation Assays and Serial Laboratory Testing in the Management of Snakebite Coagulopathy Not yet recruiting NCT04520282
24 Use of Whole Blood and Cell-rich Coagulation Assays for the Detection of Non-Overt DIC in Sepsis Terminated NCT00299949

Search NIH Clinical Center for Disseminated Intravascular Coagulation

Inferred drug relations via UMLS 70 / NDF-RT 51 :

Antithrombin III, Human

Cochrane evidence based reviews: disseminated intravascular coagulation

Genetic Tests for Disseminated Intravascular Coagulation

Genetic tests related to Disseminated Intravascular Coagulation:

# Genetic test Affiliating Genes
1 Disseminated Intravascular Coagulation 29

Anatomical Context for Disseminated Intravascular Coagulation

MalaCards organs/tissues related to Disseminated Intravascular Coagulation:

Liver, Bone, Bone Marrow, Endothelial, Kidney, Prostate, Myeloid

Publications for Disseminated Intravascular Coagulation

Articles related to Disseminated Intravascular Coagulation:

(show top 50) (show all 10186)
# Title Authors PMID Year
Platelet count and prothrombin time help distinguish thrombotic thrombocytopenic purpura-hemolytic uremic syndrome from disseminated intravascular coagulation in adults. 54 61
20154285 2010
Heparin-induced thrombocytopenia in two patients undergoing abdominal aortic aneurysm surgery. 61 54
19211578 2010
Acquired factor V inhibitor in a context of sepsis and disseminated intravascular coagulation. 61 54
20052744 2010
Study of protein C, protein S, and antithrombin III in newborns with sepsis. 61 54
19924026 2010
[Is venous thrombembolism during pregnancy an indication for routine assay of antithrombin activity and antithrombin supplementation?]. 54 61
20232702 2010
Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome and disseminated intravascular coagulation patients. 54 61
19487982 2010
Management and outcome of patients with acute traumatic subdural hematomas and pre-injury oral anticoagulation therapy. 54 61
19570326 2009
Recombinant human antithrombin expressed in the milk of non-transgenic goats exhibits high efficiency on rat DIC model. 61 54
19455283 2009
Hemostatic abnormalities in patients with closed head injuries and their role in predicting early mortality. 61 54
19697972 2009
Effects of antithrombin III in patients with disseminated intravascular coagulation diagnosed by newly developed diagnostic criteria for critical illness. 61 54
18840625 2009
Relationship between disseminated intravascular coagulation and levels of plasma thrombinogen segment 1+2, D-dimer, and thrombomodulin in patients with multiple injuries. 54 61
19635212 2009
Influence of antithrombin and argatroban on disseminated intravascular coagulation parameters in a patient with septic shock. 54 61
19062078 2009
Non-overt disseminated intravascular coagulation scoring for critically ill patients: the impact of antithrombin levels. 61 54
19350114 2009
[Severe sepsis and disseminated intravascular coagulation. Supplementation with antithrombin]. 61 54
19189066 2009
[Case of severe streptococcus pyogenes pneumonia with streptococcus toxic shock syndrome]. 54 61
18592996 2008
Severe liver disease in pregnancy. 61 54
18321514 2008
[Early postoperative systemic inflammatory response in patients with lower extremity atherosclerotic gangrene]. 54 61
18652169 2008
Life-threatening coagulopathy associated with use of Campath (alemtuzumab) in maintenance steroid-free renal transplant given before surgery. 54 61
18294351 2008
Serum thrombomodulin level relates to the clinical course of disseminated intravascular coagulation, multiorgan dysfunction syndrome, and mortality in patients with sepsis. 54 61
18431261 2008
Blood coagulation, inflammation, and malaria. 61 54
18260002 2008
Suppression of HUVEC tissue factor synthesis by antisense oligodeoxynucleotide. 61 54
17920661 2008
Redirection of the reaction between activated protein C and a serpin to the substrate pathway. 61 54
18045665 2008
Elevated factor VIII in hereditary haemorrhagic telangiectasia (HHT): association with venous thromboembolism. 54 61
18000608 2007
Update on hemostasis: neurosurgery. 54 61
18019938 2007
4G4G genotype of the plasminogen activator inhibitor-1 promoter polymorphism associates with disseminated intravascular coagulation in children with systemic meningococcemia. 61 54
17697137 2007
Decreased ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin type 1 repeats) is associated with a poor prognosis in sepsis-induced organ failure. 61 54
17944029 2007
Differences in antithrombin III activities by administration method in critical patients with disseminated intravascular coagulation: a pharmacokinetic study. 61 54
17515857 2007
Enoxaparin-induced skin necrosis: a fatal outcome. 54 61
17667218 2007
Mesenteric venous thrombosis. Associated systemic disorders and hypercoagulability status of 21 surgical patients. 61 54
17629043 2007
Crucial roles of GATA-2 and SP1 in adrenomedullin-affected expression of tissue factor pathway inhibitor in human umbilical vein endothelial cells exposed to lipopolysaccharide. 61 54
17479196 2007
The initial experience of antithrombin III in the management of neonates with necrotizing enterocolitis. 61 54
17448770 2007
Justifying the clinical use of fresh frozen plasma - an audit. 61 54
17462177 2007
[Place of antithrombin III concentrate in the intensive care of disseminated intravascular coagulation]. 54 61
17563999 2007
Serum albumin levels anticipate antithrombin III activities before and after antithrombin III agent in critical patients with disseminated intravascular coagulation. 54 61
17224787 2007
Double hazard of thrombophilia and bleeding in leukemia. 54 61
18024623 2007
Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a phase III, randomized, double-blind clinical trial. 54 61
17059423 2007
Anti-heparin/PF4 complexes by ELISA in patients with disseminated intravascular coagulation. 61 54
20224256 2007
Recombinant human antithrombin expressed in Chinese hamster ovary cells shows in vivo efficacy on rat DIC model similarly to plasma-derived antithrombin regardless of different N-glycosylation. 61 54
16844203 2007
Antithrombin and hypercoagulability in sepsis: insights from thrombelastography? 54 61
17331267 2007
Plasminogen activator inhibitor 1 promotes a poor prognosis in sepsis-induced disseminated intravascular coagulation. 61 54
17189219 2006
Haemostatic problems in acute promyelocytic leukaemia. 61 54
16757074 2006
A systematic review of antithrombin concentrate use in patients with disseminated intravascular coagulation of severe sepsis. 54 61
16988545 2006
Pathogenesis of thrombocytopenia in cyanotic congenital heart disease. 61 54
16828603 2006
Diagnosis and prognosis of overt disseminated intravascular coagulation in a general hospital -- meaning of the ISTH score system, fibrin monomers, and lipoprotein-C-reactive protein complex formation. 54 61
16680742 2006
Frequency of abnormal biphasic aPTT clot waveforms in patients with underlying disorders associated with disseminated intravascular coagulation. 54 61
16708120 2006
Polymorphism in the tissue factor region is associated with basal but not endotoxin-induced tissue factor-mRNA levels in leukocytes. 61 54
16634740 2006
Abdominal cluster transplantation and management of perioperative hemodynamic changes. 54 61
16481278 2006
Tissue factor in trauma and organ dysfunction. 54 61
16479462 2006
The Leiden mutation and activated protein C resistance as risk factors for disseminated intravascular coagulation in acutely poisoned patients. 61 54
16496494 2006
Treatment effects of high-dose antithrombin without concomitant heparin in patients with severe sepsis with or without disseminated intravascular coagulation. 61 54
16409457 2006

Variations for Disseminated Intravascular Coagulation

Expression for Disseminated Intravascular Coagulation

Search GEO for disease gene expression data for Disseminated Intravascular Coagulation.

Pathways for Disseminated Intravascular Coagulation

Pathways related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
Show member pathways
Show member pathways
Show member pathways
Show member pathways
11.86 F9 F7 F2 F10
7 11.85 THBD SERPINE1 IL6 FN1 F3
Show member pathways
11.73 FN1 FGA F2
12 11.47 PLG PLAT FN1 FGA
14 11.2 PLG FN1 F2
15 10.88 F9 F7 F2 F10

GO Terms for Disseminated Intravascular Coagulation

Cellular components related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 10.18 SERPINF2 SERPINE1 SERPINC1 PPIC PLG PLAT
2 extracellular region GO:0005576 10.16 SERPINF2 SERPINE1 SERPINC1 PLG PLAT IL6
3 cell surface GO:0009986 10.03 THBD SERPINF2 PLG PLAT FGA F3
4 blood microparticle GO:0072562 9.88 SERPINF2 SERPINC1 PLG FN1 FGA F2
5 endoplasmic reticulum lumen GO:0005788 9.85 SERPINC1 IL6 FN1 FGA F9 F7
6 platelet alpha granule lumen GO:0031093 9.8 SERPINF2 SERPINE1 PLG FN1 FGA F5
7 Golgi lumen GO:0005796 9.78 F9 F7 F2 F10
8 collagen-containing extracellular matrix GO:0062023 9.73 SERPINF2 SERPINE1 SERPINC1 PLG PLAT FN1
9 fibrinogen complex GO:0005577 9.63 SERPINF2 FN1 FGA
10 extracellular space GO:0005615 9.55 THBD SERPINF2 SERPINE1 SERPINC1 PLG PLAT
11 platelet alpha granule GO:0031091 9.52 FGA F5
12 intrinsic component of external side of plasma membrane GO:0031233 9.51 F3 F10
13 serine-type peptidase complex GO:1905286 9.49 F7 F3

Biological processes related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 10.03 PLG PLAT F9 F7 F2 F10
2 post-translational protein modification GO:0043687 9.96 SERPINC1 IL6 FN1 FGA F5
3 extracellular matrix organization GO:0030198 9.94 SERPINE1 FN1 FGA ADAMTS13
4 leukocyte migration GO:0050900 9.91 THBD FN1 F2 ELANE
5 ER to Golgi vesicle-mediated transport GO:0006888 9.91 F9 F7 F5 F2 F10
6 cellular protein metabolic process GO:0044267 9.87 SERPINC1 PLG IL6 FN1 FGA F5
7 platelet degranulation GO:0002576 9.85 SERPINF2 SERPINE1 PLG FN1 FGA F5
8 cell-matrix adhesion GO:0007160 9.83 FN1 FGA ADAMTS13
9 platelet activation GO:0030168 9.83 IL6 FGA F2 ADAMTS13
10 protein processing GO:0016485 9.79 F7 F3 ADAMTS13
11 positive regulation of interleukin-8 production GO:0032757 9.78 SERPINE1 IL6 F3 ELANE
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.77 SERPINF2 IL6 ELANE
13 acute-phase response GO:0006953 9.76 SERPINF2 IL6 FN1 F2
14 hemostasis GO:0007599 9.7 THBD SERPINC1 PLG FGA F9 F7
15 positive regulation of blood coagulation GO:0030194 9.67 SERPINE1 F7 F2
16 negative regulation of blood coagulation GO:0030195 9.65 THBD SERPINE1
17 positive regulation of leukocyte chemotaxis GO:0002690 9.65 IL6 F7
18 negative regulation of fibrinolysis GO:0051918 9.65 THBD SERPINF2 SERPINE1 PLG F2
19 regulation of blood coagulation GO:0030193 9.64 SERPINC1 F2
20 positive regulation of positive chemotaxis GO:0050927 9.63 F7 F3
21 negative regulation of chemokine production GO:0032682 9.63 IL6 ELANE
22 fibrinolysis GO:0042730 9.63 SERPINF2 SERPINE1 PLG PLAT FGA F2
23 plasminogen activation GO:0031639 9.62 PLAT FGA
24 negative regulation of platelet activation GO:0010544 9.61 THBD F2
25 acute inflammatory response to antigenic stimulus GO:0002438 9.59 SERPINC1 ELANE
26 blood coagulation, fibrin clot formation GO:0072378 9.58 FN1 FGA
27 negative regulation of plasminogen activation GO:0010757 9.58 SERPINF2 SERPINE1
28 blood coagulation, extrinsic pathway GO:0007598 9.58 F7 F3 F10
29 interaction with symbiont GO:0051702 9.57 PLG FN1
30 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.55 F7 F3
31 neutrophil mediated killing of gram-negative bacterium GO:0070945 9.54 F2 ELANE
32 blood coagulation GO:0007596 9.4 THBD SERPINC1 PLG PLAT FGA F9

Molecular functions related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 10.06 PLG PLAT F9 F7 F2 F10
2 calcium ion binding GO:0005509 9.91 THBD F9 F7 F2 F10 ADAMTS13
3 signaling receptor binding GO:0005102 9.91 SERPINE1 PLG PLAT FN1 FGA F7
4 peptidase activity GO:0008233 9.86 PLG PLAT F9 F7 F2 F10
5 endopeptidase activity GO:0004175 9.72 PLG F9 F7 ELANE ADAMTS13
6 heparin binding GO:0008201 9.71 SERPINC1 FN1 F2 ELANE
7 serine-type endopeptidase inhibitor activity GO:0004867 9.65 SERPINF2 SERPINE1 SERPINC1
8 protease binding GO:0002020 9.63 SERPINF2 SERPINE1 SERPINC1 FN1 F3 ELANE
9 serine-type peptidase activity GO:0008236 9.5 PLG PLAT F9 F7 F2 F10
10 serine-type endopeptidase activity GO:0004252 9.23 PLG PLAT F9 F7 F3 F2

Sources for Disseminated Intravascular Coagulation

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
69 Tocris
71 UMLS via Orphanet
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