Disseminated Intravascular Coagulation

Categories: Immune diseases, Blood diseases

Aliases & Classifications for Disseminated Intravascular Coagulation

MalaCards integrated aliases for Disseminated Intravascular Coagulation:

Name: Disseminated Intravascular Coagulation 12 37 29 55 44 15 63 73
Diffuse or Disseminated Intravascular Coagulation 12
Defibrination Syndrome 12
Dic 12


External Ids:

Disease Ontology 12 DOID:11247
ICD10 33 D65
ICD9CM 35 286.6
MeSH 44 D004211
NCIt 50 C2992
SNOMED-CT 68 267563002 67406007
KEGG 37 H01587
UMLS 73 C0012739

Summaries for Disseminated Intravascular Coagulation

PubMed Health : 63 About disseminated intravascular coagulation: Disseminated intravascular coagulation (ko-ag-u-LA-shun), or DIC, is a condition in which blood clots form throughout the body's small blood vessels. These blood clots can reduce or block blood flow through the blood vessels, which can damage the body's organs.In DIC, the increased clotting uses up platelets (PLATE-lets) and clotting factors in the blood. Platelets are blood cell fragments that stick together to seal small cuts and breaks on blood vessel walls and stop bleeding. Clotting factors are proteins needed for normal blood clotting.With fewer platelets and clotting factors in the blood, serious bleeding can occur. DIC can cause internal and external bleeding.Internal bleeding occurs inside the body. External bleeding occurs underneath or from the skin or mucosa. (The mucosa is the tissue that lines some organs and body cavities, such as your nose and mouth.)DIC can cause life-threatening bleeding.

MalaCards based summary : Disseminated Intravascular Coagulation, also known as diffuse or disseminated intravascular coagulation, is related to purpura fulminans and protein c deficiency. An important gene associated with Disseminated Intravascular Coagulation is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Thrombin and Tranexamic Acid have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and endothelial, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and homeostasis/metabolism

Wikipedia : 76 Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the... more...

Related Diseases for Disseminated Intravascular Coagulation

Diseases related to Disseminated Intravascular Coagulation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 385)
# Related Disease Score Top Affiliating Genes
1 purpura fulminans 32.9 F2 F3 SERPINC1 SERPINF2
2 protein c deficiency 31.4 F2 F5 F9 SERPINC1 THBD
3 thrombotic thrombocytopenic purpura 31.1 ADAMTS13 F3 THBD
4 hemorrhagic fever 31.1 F2 F3 SERPINC1
5 heparin-induced thrombocytopenia 31.0 F3 SERPINC1
6 osteonecrosis 30.9 F2 SERPINC1 SERPINE1
7 meningococcemia 30.9 F5 SERPINC1 SERPINE1 THBD
8 placenta disease 30.8 F3 F5 SERPINC1
9 placental abruption 30.7 F2 F5 SERPINC1 THBD
10 protein s deficiency 30.7 F2 F3 F5 SERPINC1
11 purpura 30.6 ADAMTS13 F2 F3 SERPINC1 THBD
12 liver cirrhosis 30.6 F2 SERPINC1 SERPINF2
13 antithrombin iii deficiency 30.6 F2 F5 SERPINC1
14 shwartzman phenomenon 30.5 F3 SERPINE1 THBD
15 pulmonary edema 30.3 F2 PIK3C2A SERPINC1
16 esophageal varix 30.3 F2 SERPINC1
17 blue toe syndrome 30.2 F2 F3 SERPINC1 SERPINE1
18 endocarditis 30.1 F2 PIK3C2A PLAT SERPINC1
19 compartment syndrome 30.1 F2 MB PIK3C2A
20 giant hemangioma 30.0 F2 F3 SERPINC1 SERPINF2
21 korean hemorrhagic fever 30.0 F2 F3 SERPINC1 SERPINF2
22 acute promyelocytic leukemia 30.0 ELANE F3 SERPINC1 SERPINF2 THBD
23 catastrophic antiphospholipid syndrome 29.9 ADAMTS13 F3 F5 SERPINE1
24 coronary thrombosis 29.9 F3 PLAT SERPINC1 SERPINE1
25 factor xiii deficiency 29.6 F3 F5 SERPINE1 SERPINF2
26 cardiac tamponade 29.6 F2 F9
27 portal vein thrombosis 29.2 F2 F5 F7 SERPINC1 SERPINE1
28 antiphospholipid syndrome 28.8 ADAMTS13 F2 F3 F5 PLAT SERPINC1
29 thrombophilia due to thrombin defect 28.8 F2 F3 F5 PLAT SERPINC1 SERPINE1
30 hemophilia 28.7 F2 F3 F7 F9
31 marantic endocarditis 28.6 F2 F3 PLAT SERPINC1 SERPINF2 THBD
32 hellp syndrome 28.3 ADAMTS13 F2 F3 F5 PLAT SERPINC1
33 thrombosis 28.2 F2 F3 F5 F9 PLAT SERPINC1
34 hemophilia b 28.1 F2 F3 F7 F9 SERPINC1
35 factor x deficiency 27.9 F2 F3 F5 F7 F9 SERPINC1
36 acute myocardial infarction 27.5 F3 MB PIK3C2A PLAT SERPINC1 SERPINE1
37 pulmonary embolism 27.1 F2 F3 F5 F9 PLAT SERPINC1
38 stroke, ischemic 26.1 F2 F3 F5 F7 FGA PLAT
39 hemorrhagic disease 25.7 ADAMTS13 F2 F3 F5 F7 F9
40 myocardial infarction 23.8 ADAMTS13 F2 F3 F5 F7 FGA
41 dic in newborn 11.7
42 acute monoblastic leukemia 11.5
43 kidney cortex necrosis 11.2
44 cerebral falx meningioma 10.9 F2 F3
45 blood protein disease 10.9 F2 SERPINC1
46 paracetamol poisoning 10.8 F2 F5
47 qualitative platelet defect 10.8 F2 F3
48 inferior vena cava interruption 10.8 F5 SERPINE1
49 von willebrand disease, type 1 10.8 F2 F3
50 amaurosis fugax 10.8 F5 SERPINE1

Comorbidity relations with Disseminated Intravascular Coagulation via Phenotypic Disease Network (PDN): (show all 15)

Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Aortic Valve Disease 1 Cardiac Arrest
Chronic Kidney Failure Decubitus Ulcer
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Mitral Valve Disease
Prostate Cancer Protein-Energy Malnutrition
Respiratory Failure

Graphical network of the top 20 diseases related to Disseminated Intravascular Coagulation:

Diseases related to Disseminated Intravascular Coagulation

Symptoms & Phenotypes for Disseminated Intravascular Coagulation

GenomeRNAi Phenotypes related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 PIK3C2A SERPINC1 SERPINE1 SERPINF2 THBD

MGI Mouse Phenotypes related to Disseminated Intravascular Coagulation:

# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.24 THBD PLAT SERPINC1 SERPINE1 SERPINF2 PIK3C2A
2 cardiovascular system MP:0005385 10.23 THBD PLAT SERPINC1 SERPINE1 F5 PIK3C2A
3 hematopoietic system MP:0005397 10.18 PIK3C2A THBD PLAT SERPINC1 SERPINE1 ADAMTS13
4 embryo MP:0005380 10.09 PIK3C2A THBD SERPINC1 F5 F9 F2
5 immune system MP:0005387 10.06 PIK3C2A THBD PLAT SERPINC1 SERPINE1 ADAMTS13
6 integument MP:0010771 9.8 THBD PLAT SERPINE1 F5 F2 FGA
7 mortality/aging MP:0010768 9.8 PIK3C2A THBD PLAT SERPINC1 SERPINE1 F5
8 liver/biliary system MP:0005370 9.63 THBD SERPINC1 SERPINE1 F5 F9 FGA
9 respiratory system MP:0005388 9.1 THBD PLAT SERPINE1 F2 F3 MB

Drugs & Therapeutics for Disseminated Intravascular Coagulation

PubMedHealth treatment related to Disseminated Intravascular Coagulation: 63

Treatment for disseminated intravascular coagulation (DIC) depends on its severity and cause. The main goals of treating DIC are to control bleeding and clotting problems and treat the underlying cause.

Drugs for Disseminated Intravascular Coagulation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 122)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Thrombin Approved, Investigational Phase 4
Tranexamic Acid Approved Phase 4,Phase 3 1197-18-8 5526
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
Labetalol Approved Phase 4 36894-69-6 3869
Methyldopa Approved Phase 4 555-30-6 38853
Nifedipine Approved Phase 4 21829-25-4 4485
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
8 Calcium, Dietary Phase 4,Phase 3,Phase 2
9 Antifibrinolytic Agents Phase 4,Phase 3
10 Coagulants Phase 4,Phase 3
11 Factor VIII Phase 4
12 Hemostatics Phase 4,Phase 3
13 Liver Extracts Phase 4
14 Platelet Aggregation Inhibitors Phase 4
15 Prasugrel hydrochloride Phase 4 389574-19-0
16 Thromboplastin Phase 4,Not Applicable
17 Adrenergic Agents Phase 4,Not Applicable
18 Adrenergic Agonists Phase 4,Not Applicable
19 Adrenergic alpha-2 Receptor Agonists Phase 4
20 Adrenergic alpha-Agonists Phase 4,Not Applicable
21 Analgesics Phase 4,Phase 3
22 Analgesics, Non-Narcotic Phase 4
23 Central Nervous System Depressants Phase 4
24 Hypnotics and Sedatives Phase 4
25 Neurotransmitter Agents Phase 4,Not Applicable
26 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
27 Autonomic Agents Phase 4,Phase 3,Not Applicable
28 Adrenergic alpha-1 Receptor Antagonists Phase 4
29 Adrenergic alpha-Antagonists Phase 4
30 Adrenergic Antagonists Phase 4
31 Adrenergic beta-Antagonists Phase 4
32 Antihypertensive Agents Phase 4
33 calcium channel blockers Phase 4
34 Sympatholytics Phase 4
35 Tocolytic Agents Phase 4
36 Vasodilator Agents Phase 4
37 Anesthetics Phase 4,Not Applicable
38 Antigen-Antibody Complex Phase 4,Phase 2
39 Anti-Arrhythmia Agents Phase 4
40 Anticonvulsants Phase 4
Heparin Approved, Investigational Phase 3,Phase 2,Not Applicable 9005-49-6 772 46507594
Lenograstim Approved, Investigational Phase 2, Phase 3 135968-09-1
Arsenic trioxide Approved, Investigational Phase 3 1327-53-3 518740
Cytarabine Approved, Investigational Phase 3 147-94-4 6253
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
Idarubicin Approved Phase 3 58957-92-9 42890
Mitoxantrone Approved, Investigational Phase 3 65271-80-9 4212
Serine Approved, Nutraceutical Phase 2, Phase 3,Phase 3 56-45-1 5951
Tretinoin Approved, Investigational, Nutraceutical Phase 3 302-79-4 5538 444795
Vitamin A Approved, Nutraceutical, Vet_approved Phase 3 11103-57-4, 68-26-8 445354

Interventional clinical trials:

(show top 50) (show all 57)
# Name Status NCT ID Phase Drugs
1 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
2 Clinical Pharmacokinetics Study of ART-123 in Disseminated Intravascular Coagulation (DIC) Subjects With Renal Impairment Completed NCT01704001 Phase 4 ART-123
3 A Comparison Study of Bypassing Agent Therapy With and Without Tranexamic Acid in Haemophilia A Patients With Inhibitor Completed NCT01800435 Phase 4 aPCC, aPCC + TXA;rFVIIa, rFVIIa + TXA
4 The Role of the P2Y12 Receptor in Tissue Factor Induced Coagulation Completed NCT01099566 Phase 4 Prasugrel;Placebo
5 Dexmedetomidine for Sepsis in ICU Randomized Evaluation Trial Completed NCT01760967 Phase 4 Dexmedetomidine
6 Early Vascular Adjustments During Hypertensive Pregnancy Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
7 The Efficacy of Xuebijing Injection on Sepsis Recruiting NCT03238742 Phase 4 Xuebijing Injection;0.9% normal saline
8 Prevention of Postpartum Hemorrhage With TXA Recruiting NCT03326596 Phase 4 Tranexamic Acid 1000 mg/10ml normal saline infusion
9 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
10 Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock Trial. VIPER-Sepsis (EudraCT no. 2016-000707-81) Terminated NCT02875236 Phase 4 OctaplasLG®;Ringer-acetat
11 Efficacy and Safety of Unfractionated Heparin on Severe Sepsis With Suspected Disseminated Intravascular Coagulation Unknown status NCT02654561 Phase 3 Heparin Sodium;Saline
12 The Effect of Ulinastatin on Bronchoalveolar Lavage Fluid of Inflammatory Factors in Patients With Ventilator-associated Pneumonia Unknown status NCT01865266 Phase 2, Phase 3 Ulinaststin for injection;placebo
13 An Open-label Study of KW-3357 Completed NCT01384903 Phase 3 KW-3357;Plasma-derived antithrombin
14 A Clinical Study of KW-3357 in Patients With DIC Completed NCT01384396 Phase 3 KW-3357
15 Impact of Low Dose Unfractionated Heparin Treatment on Inflammation in Sepsis Completed NCT02135770 Phase 3 Unfractionated heparin
16 Heparin Binding Protein in Patients With Acute Respiratory Failure Treated With GCSF (Filgrastim) Completed NCT01713309 Phase 2, Phase 3 Filgrastim
17 Comparison of Topical and Intravenous Tranexamic Acid in Total Hip Arthroplasty Completed NCT02312440 Phase 3 0.9% sodium chloride;tranexamic acid;tranexamic acid
18 Comparison of Topical Versus Intravenous Tranexamic Acid in TKA Completed NCT02393300 Phase 3 normal saline;Tranexamic Acid;Tranexamic Acid
19 Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic Leukemia Recruiting NCT02339740 Phase 3 Arsenic Trioxide;Cytarabine;Dexamethasone;Idarubicin;Mitoxantrone Hydrochloride;Tretinoin
20 Nebulized Epinephrine and Oral Dexamethasone in Bronchiolitis Not yet recruiting NCT03567473 Phase 3 Oral dexamethasone;Nebulized Epinephrine;Oral placebo;Nebulized normal saline
21 A Phase 3 Clinical Study of KW-3357 in Patients With DIC Terminated NCT01384409 Phase 3 KW-3357
22 A Phase III Efficacy and Safety Study of Intravenous Retosiban Versus Placebo for Women in Spontaneous Preterm Labor Terminated NCT02377466 Phase 3 Retosiban IV infusion;Placebo IV infusion
23 Safety and Efficacy of ART-123 in Subjects With Sepsis and Disseminated Intravascular Coagulation Completed NCT00487656 Phase 2 ART-123;placebo
24 GR270773 In The Treatment Of Suspected Or Confirmed Gram-Negative Severe Sepsis In Adults Completed NCT00089986 Phase 2 Intravenous GR270773- Phospholipid Emulsion
25 Recombinant Vaccinia Virus Administered Intravenously in Patients With Metastatic, Refractory Colorectal Carcinoma Completed NCT01394939 Phase 1, Phase 2 Irinotecan
26 Safety and Efficacy of the ONCOlytic VIRus Armed for Local Chemotherapy, TG6002/5-FC, in Recurrent Glioblastoma Patients Recruiting NCT03294486 Phase 1, Phase 2 Combination of TG6002 and 5-flucytosine (5-FC, Ancotil®)
27 Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock (SHOCK) Trial Recruiting NCT03092245 Phase 2 OctaplasLG;Ringer-Acetate
28 Recombinant Human Antithrombin (ATryn®) in the Treatment of Patients With DIC Associated With Severe Sepsis Terminated NCT00506519 Phase 2 antithrombin alfa (INN name)
29 4G/5G Polymorphism of Plasminogen Activator Inhibitor-1 Gene and Disseminated Intravascular Coagulation in Severe Sepsis and Septic Shock Unknown status NCT01211899
30 Hypercoagulation Screening in Cancer Unknown status NCT02622815
31 Interest of the Balance of Pro-coagulating and Profibrinolytis Activities of the Microparticles (MP) in the Prognosis of Septic Shock Unknown status NCT02062970 Not Applicable
32 Coagulation Factor Changes Associated With Postpartum Hysterectomies Completed NCT00456547
33 Role of the Circulating Procoagulants Microparticles in the Hypercoagulability of MNP Ph1- Completed NCT02862366
34 Evaluation of Endothelial Dysfunction During Aortic Valvular Replacement by Bioprosthesis With and Without Extracorporeal Circulation Completed NCT03135496
35 Study of New Biological Markers for Prediction of Severe Acute Pancreatitis Completed NCT00786591
36 TC-325 (HEMOSPRAY™) VS. CURRENT STANDARD OF CARE IN MANAGING MALIGNANT GASTROINTESTINAL BLEEDING: A PILOT STUDY TO INFORM A RANDOMIZED CONTROLLED TRIAL. Completed NCT02135627 Not Applicable TC-325 monotherapy on initial endoscopy ± radiation therapy, angioembolization, and/or surgery.
37 Correlation Between Cytokines and the Severity of Meningococcal Disease Completed NCT01133834
38 The Use of the Bakri Postpartum Balloon in the Management of Postpartum Hemorrhage Refractory to Conservative Measures Completed NCT01844089
39 Impact of Monitoring Quality Indicators in Maternity Departments on Mother and Infant Health Completed NCT01459978
40 The Procalcitonin and Survival Study Completed NCT00271752 Not Applicable
41 Retrospective Longitudinal Study of Gestational Weight Gain Among Chinese Pregnant Women Completed NCT03154268
42 International Prospective Registry of Disseminated Intravascular Coagulation Recruiting NCT03577015
43 Thromboelastometry Guided DIC Prevention After Cesarean Section in Pregnant Women With Placenta Previa Recruiting NCT03266432 Not Applicable
44 Rotational Thromboelastometry for the Transfusion Management of Postpartum Hemorrhage After Vaginal or Cesarean Delivery Recruiting NCT03064152 Not Applicable
45 Prospective, Non-interventional Study to Evaluate the Safety and Effectiveness of Obizur in Real-life Practice Recruiting NCT03199794
46 Oxidative Stress and Endothelial Function in Pregnancy Complications Recruiting NCT02603913
47 Preeclampsia Ratio (sFlt-1/PlGF) Recruiting NCT03289611 Not Applicable
48 sFlt-1:PlGF Ratio in Diagnosing Superimposed Preeclampsia Recruiting NCT03441711
49 Fetal Pillow Randomized Controlled Trial Recruiting NCT03342508 Not Applicable
50 Erythrocyte Transfusion Based on the Measurement of Central Venous Oxygen Saturation in Postoperative Cardiac Surgery Recruiting NCT02963883 Not Applicable

Search NIH Clinical Center for Disseminated Intravascular Coagulation

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: disseminated intravascular coagulation

Genetic Tests for Disseminated Intravascular Coagulation

Genetic tests related to Disseminated Intravascular Coagulation:

# Genetic test Affiliating Genes
1 Disseminated Intravascular Coagulation 29

Anatomical Context for Disseminated Intravascular Coagulation

MalaCards organs/tissues related to Disseminated Intravascular Coagulation:

Skin, Liver, Endothelial, Bone, Prostate, Neutrophil, Testes

Publications for Disseminated Intravascular Coagulation

Articles related to Disseminated Intravascular Coagulation:

(show top 50) (show all 949)
# Title Authors Year
Risk factors for disseminated intravascular coagulation in patients with lung cancer. ( 29851300 )
Prediction of Disseminated Intravascular Coagulation by Liver Function Tests in Patients with Japanese Spotted Fever. ( 29021432 )
Clinical characteristics of disseminated intravascular coagulation in patients with solid and hematological cancers. ( 29703488 )
Management of disseminated intravascular coagulation: current insights on antithrombin and thrombomodulin treatments. ( 29343993 )
Genistein has the function of alleviating and treating disseminated intravascular coagulation caused by lipopolysaccharide. ( 29761425 )
Screening itself for disseminated intravascular coagulation may reduce mortality in sepsis: A nationwide multicenter registry in Japan. ( 29202320 )
Enterohemorrhagic colitis with disseminated intravascular coagulation. ( 29904297 )
How I treat disseminated intravascular coagulation. ( 29255070 )
<i>ALK</i>-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation. ( 29850298 )
Newly Proposed Sepsis-Induced Coagulopathy Precedes International Society on Thrombosis and Haemostasis Overt-Disseminated Intravascular Coagulation and Predicts High Mortality. ( 29720054 )
Pathogenesis and diagnosis of disseminated intravascular coagulation. ( 29741245 )
Thrombotic and hemorrhagic complications during visceral transplantation: risk factors, and association with intraoperative disseminated intravascular coagulation-like thromboelastographic qualities: a single-center retrospective study. ( 29786890 )
Bilateral orbital compartment syndrome in a patient with disseminated intravascular coagulation. ( 29308942 )
International Normalized Ratio Relevance to the Observed Coagulation Abnormalities in Warfarin Treatment and Disseminated Intravascular Coagulation. ( 29848060 )
Clinical Impact of Recombinant Soluble Thrombomodulin for Disseminated Intravascular Coagulation Associated with Severe Acute Cholangitis. ( 29699063 )
Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways. ( 29921614 )
Machine learning-based diagnosis for disseminated intravascular coagulation (DIC): Development, external validation, and comparison to scoring systems. ( 29718941 )
A rare variant of t(17;19) in a case of Philadelphia positive adult acute lymphoblastic leukemia presenting with disseminated intravascular coagulation. ( 29662872 )
Antithrombin concentrate use in disseminated intravascular coagulation of sepsis: meta-analyses revisited. ( 29316235 )
Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies-what intensivists need to know. ( 29895296 )
Recombinant Thrombomodulin Used to Successfully Treat Cronkhite-Canada Syndrome with Disseminated Intravascular Coagulation due to Sepsis in a Compromised Patient: A Case Report. ( 29877275 )
The disseminated intravascular coagulation score is a novel predictor for portal vein thrombosis in cirrhotic patients with hepatitis B. ( 29178991 )
A summary of the Japan septic disseminated intravascular coagulation study. ( 29657722 )
No impact of disseminated intravascular coagulation in kidney donors on long-term kidney transplantation outcome: A multicenter propensity-matched study. ( 29981217 )
Successful management of obstetric disseminated intravascular coagulation using a portable fibrinogen-measuring device. ( 29359377 )
Disseminated intravascular coagulation: is it fact or fancy? ( 29621007 )
Antithrombin concentrate use in sepsis-associated disseminated intravascular coagulation: re-evaluation of a 'pendulum effect' drug using a nationwide database. ( 29316251 )
Evaluation of disseminated intravascular coagulation scores in critically ill pediatric patients with septic shock. ( 29940405 )
Delayed disseminated intravascular coagulation revealed by spontaneous hematomas after conservative treatment of placenta percreta. ( 29804883 )
Impact of non-anticoagulant therapy on patients with sepsis-induced disseminated intravascular coagulation: A multicenter, case-control study. ( 29329022 )
Primary Hepatic Angiosarcoma Mimicking Multifocal Liver Abscess with Disseminated Intravascular Coagulation and Hemoperitoneum. ( 28680781 )
Effect of Thrombomodulin Alfa on Disseminated Intravascular Coagulation in Patients with Lung Cancer. ( 28717074 )
Dramatic response of acute disseminated intravascular coagulation to erlotinib in a patient with lung adenocarcinoma with activating EGFR mutation. ( 28730909 )
TAFRO Syndrome with Disseminated Intravascular Coagulation Successfully Treated with Tocilizumab and Recombinant Thrombomodulin. ( 29279488 )
Population pharmacokinetics of thrombomodulin alfa in pediatric patients with hematological malignancy and disseminated intravascular coagulation. ( 27734584 )
Reply to the editor- Disseminated intravascular coagulation as a cause of shock related to device extraction. ( 29180120 )
Low plasma FVII:C and activated FVII as predictive markers for overt disseminated intravascular coagulation. ( 28492702 )
Circulating syndecan-1 predicts the development of disseminated intravascular coagulation in patients with sepsis. ( 28843664 )
Acute exacerbation of chronic disseminated intravascular coagulation associated with thoracoabdominal aortic aneurysm after tooth extraction. ( 28766813 )
Prognostic significance of disseminated intravascular coagulation in patients with heat stroke in a nationwide registry. ( 29253838 )
Thrombotic Thrombocytopenic Purpura or Disseminated Intravascular Coagulation? ( 28904488 )
Disseminated intravascular coagulation with increased fibrinolysis during the early phase of isolated traumatic brain injury. ( 28826407 )
Atractylenolide a8 protects against lipopolysaccharide-induced disseminated intravascular coagulation by anti-inflammatory and anticoagulation effect. ( 28756923 )
Recurrent Early Coronary Stent Thrombosis under Chronic Disseminated Intravascular Coagulation. ( 29162782 )
Understanding and treating solid tumor-related disseminated intravascular coagulation in the &amp;quot;era&amp;quot; of targeted cancer therapies. ( 29318012 )
Erratum: Current Pathological and Laboratory Considerations in the Diagnosis of Disseminated Intravascular Coagulation. ( 27834077 )
Successful Treatment with 5-fluorouracil and Levofolinate Calcium in Advanced Gastric Cancer Patient with Disseminated Intravascular Coagulation. ( 29066681 )
To the Editor- Disseminated intravascular coagulation as a cause of shock related to device extraction. ( 29180121 )
Disseminated Intravascular Coagulation (DIC) ( 28722864 )
Platinum-based Doublet Chemotherapy for Advanced Gastric Cancer with Disseminated Intravascular Coagulation. ( 28011507 )

Variations for Disseminated Intravascular Coagulation

Expression for Disseminated Intravascular Coagulation

Search GEO for disease gene expression data for Disseminated Intravascular Coagulation.

Pathways for Disseminated Intravascular Coagulation

Pathways related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
12.97 F2 F3 F5 F7 F9 FGA
Show member pathways
12.58 F2 F3 F5 F7 F9 FGA
Show member pathways
4 11.84 F2 F3 F5 F7 F9 FGA
Show member pathways
11.67 F2 F7 F9
Show member pathways
11.57 F2 F3 F5 F7 F9 FGA
8 10.72 F2 F7 F9

GO Terms for Disseminated Intravascular Coagulation

Cellular components related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 ADAMTS13 ELANE F2 F3 F5 F7
2 cell surface GO:0009986 9.8 ADAMTS13 ELANE F3 FGA PLAT SERPINF2
3 blood microparticle GO:0072562 9.73 F2 FGA SERPINC1 SERPINF2
4 platelet alpha granule lumen GO:0031093 9.67 F5 FGA SERPINE1 SERPINF2
5 Golgi lumen GO:0005796 9.65 F2 F7 F9
6 endoplasmic reticulum lumen GO:0005788 9.5 ADAMTS13 F2 F5 F7 F9 FGA
7 platelet alpha granule GO:0031091 9.49 F5 FGA
8 fibrinogen complex GO:0005577 9.46 FGA SERPINF2
9 extracellular space GO:0005615 9.44 ADAMTS13 ELANE F2 F3 F5 F7
10 serine-type peptidase complex GO:1905286 9.4 F3 F7
11 plasma membrane GO:0005886 10.21 F2 F3 F5 F7 F9 FGA
12 extracellular exosome GO:0070062 10.06 ELANE F2 F3 F9 FGA MB

Biological processes related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.97 ADAMTS13 ELANE F2 F7 F9 PLAT
2 cellular protein metabolic process GO:0044267 9.85 F2 F5 FGA SERPINC1
3 ER to Golgi vesicle-mediated transport GO:0006888 9.83 F2 F5 F7 F9
4 negative regulation of endopeptidase activity GO:0010951 9.8 SERPINC1 SERPINE1 SERPINF2
5 negative regulation of peptidase activity GO:0010466 9.8 SERPINC1 SERPINE1 SERPINF2
6 platelet activation GO:0030168 9.79 ADAMTS13 F2 FGA
7 platelet degranulation GO:0002576 9.76 F5 FGA SERPINE1 SERPINF2
8 protein processing GO:0016485 9.74 ADAMTS13 F3 F7
9 blood coagulation GO:0007596 9.65 ADAMTS13 F2 F3 F5 F7 F9
10 positive regulation of collagen biosynthetic process GO:0032967 9.64 F2 SERPINF2
11 negative regulation of proteolysis GO:0045861 9.63 F2 PLAT
12 blood coagulation, intrinsic pathway GO:0007597 9.62 F2 F9
13 negative regulation of blood coagulation GO:0030195 9.61 SERPINE1 THBD
14 signal peptide processing GO:0006465 9.61 F2 F7 F9
15 plasminogen activation GO:0031639 9.6 FGA PLAT
16 regulation of blood coagulation GO:0030193 9.59 F2 SERPINC1
17 positive regulation of positive chemotaxis GO:0050927 9.58 F3 F7
18 negative regulation of platelet activation GO:0010544 9.58 F2 THBD
19 positive regulation of blood coagulation GO:0030194 9.58 F2 F7 SERPINE1
20 acute inflammatory response to antigenic stimulus GO:0002438 9.56 ELANE SERPINC1
21 negative regulation of fibrinolysis GO:0051918 9.56 F2 SERPINE1 SERPINF2 THBD
22 fibrinolysis GO:0042730 9.55 F2 FGA PLAT SERPINE1 SERPINF2
23 negative regulation of plasminogen activation GO:0010757 9.54 SERPINE1 SERPINF2
24 peptidyl-glutamic acid carboxylation GO:0017187 9.54 F2 F7 F9
25 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.51 F3 F7
26 blood coagulation, extrinsic pathway GO:0007598 9.5 F3 F7 F9
27 neutrophil mediated killing of gram-negative bacterium GO:0070945 9.48 ELANE F2
28 hemostasis GO:0007599 9.28 ADAMTS13 F2 F3 F5 F7 F9

Molecular functions related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.83 ADAMTS13 F2 F7 F9 THBD
2 peptidase activity GO:0008233 9.73 ADAMTS13 ELANE F2 F7 F9 PLAT
3 signaling receptor binding GO:0005102 9.72 F2 F7 FGA PLAT SERPINE1
4 heparin binding GO:0008201 9.65 ELANE F2 SERPINC1
5 peptidase inhibitor activity GO:0030414 9.63 SERPINC1 SERPINE1 SERPINF2
6 serine-type endopeptidase inhibitor activity GO:0004867 9.58 SERPINC1 SERPINE1 SERPINF2
7 serine-type peptidase activity GO:0008236 9.55 ELANE F2 F7 F9 PLAT
8 endopeptidase activity GO:0004175 9.54 ELANE F7 F9
9 serine-type endopeptidase activity GO:0004252 9.43 ELANE F2 F3 F7 F9 PLAT
10 protease binding GO:0002020 9.02 ELANE F3 SERPINC1 SERPINE1 SERPINF2

Sources for Disseminated Intravascular Coagulation

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
Loading form....