Disseminated Intravascular Coagulation (DIC)

Categories: Blood diseases, Immune diseases, Skin diseases

Aliases & Classifications for Disseminated Intravascular Coagulation

MalaCards integrated aliases for Disseminated Intravascular Coagulation:

Name: Disseminated Intravascular Coagulation 12 37 29 55 44 15 63 73
Diffuse or Disseminated Intravascular Coagulation 12
Defibrination Syndrome 12
Dic 12


External Ids:

Disease Ontology 12 DOID:11247
ICD10 33 D65
ICD9CM 35 286.6
MeSH 44 D004211
NCIt 50 C2992
SNOMED-CT 68 67406007
KEGG 37 H01587
UMLS 73 C0012739

Summaries for Disseminated Intravascular Coagulation

PubMed Health : 63 About disseminated intravascular coagulation: Disseminated intravascular coagulation (ko-ag-u-LA-shun), or DIC, is a condition in which blood clots form throughout the body's small blood vessels. These blood clots can reduce or block blood flow through the blood vessels, which can damage the body's organs.In DIC, the increased clotting uses up platelets (PLATE-lets) and clotting factors in the blood. Platelets are blood cell fragments that stick together to seal small cuts and breaks on blood vessel walls and stop bleeding. Clotting factors are proteins needed for normal blood clotting.With fewer platelets and clotting factors in the blood, serious bleeding can occur. DIC can cause internal and external bleeding.Internal bleeding occurs inside the body. External bleeding occurs underneath or from the skin or mucosa. (The mucosa is the tissue that lines some organs and body cavities, such as your nose and mouth.)DIC can cause life-threatening bleeding.

MalaCards based summary : Disseminated Intravascular Coagulation, also known as diffuse or disseminated intravascular coagulation, is related to purpura fulminans and protein c deficiency. An important gene associated with Disseminated Intravascular Coagulation is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Tranexamic Acid and Thrombin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and lung, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and homeostasis/metabolism

Wikipedia : 76 Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the... more...

Related Diseases for Disseminated Intravascular Coagulation

Diseases related to Disseminated Intravascular Coagulation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 465)
# Related Disease Score Top Affiliating Genes
1 purpura fulminans 33.1 F2 F3 SERPINC1 SERPINF2
2 protein c deficiency 32.2 F2 F5 F9 SERPINC1 THBD
3 hellp syndrome 32.2 ADAMTS13 F2 F3 F5 SERPINC1 SERPINE1
4 purpura 30.8 ADAMTS13 F2 F3 SERPINC1 THBD
5 placental abruption 30.8 F2 F5 SERPINC1 THBD
6 thrombotic thrombocytopenic purpura 30.7 ADAMTS13 F3 THBD
7 meningococcemia 30.7 F5 SERPINC1 SERPINE1 THBD
8 hemorrhagic fever 30.6 F2 F3 SERPINC1
9 acute promyelocytic leukemia 30.6 ELANE F3 SERPINC1 SERPINF2 THBD
10 endocarditis 30.5 F2 PIK3C2A PLAT SERPINC1
11 heparin-induced thrombocytopenia 30.5 F3 SERPINC1
12 liver cirrhosis 30.4 F2 F3 SERPINC1 SERPINF2
13 osteonecrosis 30.4 F2 SERPINC1 SERPINE1
14 protein s deficiency 30.4 F2 F3 F5 SERPINC1
15 hemolytic-uremic syndrome 30.4 ADAMTS13 F3 THBD
16 compartment syndrome 30.4 F2 MB PIK3C2A
17 esophageal varix 30.3 F2 SERPINC1
18 adult respiratory distress syndrome 30.2 ELANE F2 SERPINE1
19 korean hemorrhagic fever 30.2 F2 F3 SERPINC1 SERPINF2
20 antithrombin iii deficiency 30.1 F2 F5 SERPINC1
21 giant hemangioma 30.1 F2 F3 SERPINC1 SERPINF2
22 blue toe syndrome 30.0 F2 F3 SERPINC1 SERPINE1
23 ischemic colitis 30.0 F2 F5 SERPINC1 SERPINE1
24 catastrophic antiphospholipid syndrome 29.9 ADAMTS13 F3 F5 SERPINE1
25 coronary thrombosis 29.9 F3 PLAT SERPINC1 SERPINE1
26 portal vein thrombosis 29.8 F2 F5 F7 SERPINC1 SERPINE1
27 factor xiii deficiency 29.8 F3 F5 SERPINE1 SERPINF2
28 antiphospholipid syndrome 29.8 ADAMTS13 F2 F3 F5 PLAT SERPINC1
29 acquired hemophilia 29.8 F3 F5 F9
30 cardiac tamponade 29.8 F2 F9
31 marantic endocarditis 29.7 F2 F3 PLAT SERPINC1 SERPINF2 THBD
32 hemophilia 29.7 F2 F3 F7 F9
33 thrombophilia due to thrombin defect 29.7 F2 F3 F5 PLAT SERPINC1 SERPINE1
34 thrombosis 29.7 ADAMTS13 F2 F3 F5 F7 F9
35 pulmonary embolism 29.5 F2 F3 F5 F9 PLAT SERPINC1
36 von willebrand's disease 29.5 ADAMTS13 F2 F3 F5 F9
37 thrombophlebitis 29.4 F2 F5 PLAT SERPINC1 SERPINE1 SERPINF2
38 acute myocardial infarction 29.4 F3 MB PIK3C2A PLAT SERPINC1 SERPINE1
39 factor x deficiency 29.4 F2 F3 F5 F7 F9 SERPINC1
40 hemophilia b 29.3 F2 F3 F7 F9 SERPINC1
41 myocardial infarction 28.3 ADAMTS13 F2 F3 F5 F7 FGA
42 hemorrhagic disease 28.2 ADAMTS13 F2 F3 F5 F7 F9
43 dic in newborn 12.0
44 acute monoblastic leukemia 11.7
45 kidney cortex necrosis 11.3
46 leukemia 10.7
47 gastric cancer 10.5
48 aortic aneurysm 10.5
49 prostate cancer 10.5
50 acquired purpura fulminans 10.4

Comorbidity relations with Disseminated Intravascular Coagulation via Phenotypic Disease Network (PDN): (show all 15)

Acquired Thrombocytopenia Active Peptic Ulcer Disease
Acute Cystitis Acute Kidney Failure
Aortic Valve Disease 1 Cardiac Arrest
Chronic Kidney Failure Decubitus Ulcer
Deficiency Anemia Familial Atrial Fibrillation
Heart Disease Mitral Valve Disease
Prostate Cancer Protein-Energy Malnutrition
Respiratory Failure

Graphical network of the top 20 diseases related to Disseminated Intravascular Coagulation:

Diseases related to Disseminated Intravascular Coagulation

Symptoms & Phenotypes for Disseminated Intravascular Coagulation

GenomeRNAi Phenotypes related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 9.02 PIK3C2A SERPINC1 SERPINE1 SERPINF2 THBD

MGI Mouse Phenotypes related to Disseminated Intravascular Coagulation:

# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.24 ADAMTS13 ELANE F2 F3 F5 F7
2 cardiovascular system MP:0005385 10.23 F2 F3 F5 F7 F9 FGA
3 hematopoietic system MP:0005397 10.18 ADAMTS13 ELANE F2 F3 F9 FGA
4 embryo MP:0005380 10.09 F2 F3 F5 F9 FGA MB
5 immune system MP:0005387 10.06 ADAMTS13 ELANE F2 F3 F9 FGA
6 integument MP:0010771 9.8 F2 F3 F5 FGA PLAT SERPINE1
7 mortality/aging MP:0010768 9.8 ADAMTS13 ELANE F2 F3 F5 F7
8 liver/biliary system MP:0005370 9.63 F5 F9 FGA SERPINC1 SERPINE1 THBD
9 respiratory system MP:0005388 9.1 F2 F3 MB PLAT SERPINE1 THBD

Drugs & Therapeutics for Disseminated Intravascular Coagulation

PubMedHealth treatment related to Disseminated Intravascular Coagulation: 63

Treatment for disseminated intravascular coagulation (DIC) depends on its severity and cause. The main goals of treating DIC are to control bleeding and clotting problems and treat the underlying cause.

Drugs for Disseminated Intravascular Coagulation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 145)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Tranexamic Acid Approved Phase 4,Phase 3 1197-18-8 5526
Thrombin Approved, Investigational Phase 4
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
Labetalol Approved Phase 4 36894-69-6 3869
Methyldopa Approved Phase 4 555-30-6 38853
Nifedipine Approved Phase 4 21829-25-4 4485
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
8 Liver Extracts Phase 4
9 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
10 Antifibrinolytic Agents Phase 4,Phase 3
11 Coagulants Phase 4,Phase 3
12 Feiba Phase 4
13 Hemostatics Phase 4,Phase 3
14 Factor VIII Phase 4
15 Thromboplastin Phase 4,Not Applicable
16 Prasugrel hydrochloride Phase 4 389574-19-0
17 Platelet Aggregation Inhibitors Phase 4
18 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
19 Adrenergic alpha-Agonists Phase 4,Phase 3,Not Applicable
20 Adrenergic Agonists Phase 4,Phase 3,Not Applicable
21 Central Nervous System Depressants Phase 4
22 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
23 Hypnotics and Sedatives Phase 4
24 Adrenergic Agents Phase 4,Phase 3,Not Applicable
25 Adrenergic alpha-2 Receptor Agonists Phase 4
26 Analgesics, Non-Narcotic Phase 4
27 Analgesics Phase 4,Phase 3
28 Sympathomimetics Phase 4,Phase 3,Not Applicable
29 Autonomic Agents Phase 4,Phase 3,Not Applicable
30 Adrenergic alpha-1 Receptor Antagonists Phase 4
31 Tocolytic Agents Phase 4,Phase 3
32 Adrenergic alpha-Antagonists Phase 4
33 Sympatholytics Phase 4
34 Adrenergic Antagonists Phase 4
35 Antihypertensive Agents Phase 4
36 Adrenergic beta-Antagonists Phase 4
37 calcium channel blockers Phase 4
38 Vasodilator Agents Phase 4,Not Applicable
39 Anesthetics Phase 4,Not Applicable
40 Antigen-Antibody Complex Phase 4,Phase 2
41 Anti-Arrhythmia Agents Phase 4
42 Anticonvulsants Phase 4
Heparin Approved, Investigational Phase 3,Phase 2,Not Applicable 9005-49-6 772 46507594
Lenograstim Approved, Investigational Phase 2, Phase 3 135968-09-1
Epinephrine Approved, Vet_approved Phase 3,Not Applicable 51-43-4 5816
Racepinephrine Approved Phase 3,Not Applicable 329-65-7 838
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
Cytarabine Approved, Investigational Phase 3 147-94-4 6253
Mitoxantrone Approved, Investigational Phase 3 65271-80-9 4212

Interventional clinical trials:

(show top 50) (show all 68)
# Name Status NCT ID Phase Drugs
1 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
2 Clinical Pharmacokinetics Study of ART-123 in Disseminated Intravascular Coagulation (DIC) Subjects With Renal Impairment Completed NCT01704001 Phase 4 ART-123
3 A Comparison Study of Bypassing Agent Therapy With and Without Tranexamic Acid in Haemophilia A Patients With Inhibitor Completed NCT01800435 Phase 4 aPCC, aPCC + TXA;rFVIIa, rFVIIa + TXA
4 The Role of the P2Y12 Receptor in Tissue Factor Induced Coagulation Completed NCT01099566 Phase 4 Prasugrel;Placebo
5 Dexmedetomidine for Sepsis in ICU Randomized Evaluation Trial Completed NCT01760967 Phase 4 Dexmedetomidine
6 Early Vascular Adjustments During Hypertensive Pregnancy Recruiting NCT02531490 Phase 4 Labetalol;Nifedipine;Methyldopa
7 Prevention of Postpartum Hemorrhage With TXA Recruiting NCT03326596 Phase 4 Tranexamic Acid 1000 mg/10ml normal saline infusion
8 Different Schemes of Magnesium Sulfate for Preeclampsia Terminated NCT02396030 Phase 4 Magnesium sulfate 50% - 1g/h;Magnesium sulfate 50% - 2g/h
9 Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock Trial. VIPER-Sepsis (EudraCT no. 2016-000707-81) Terminated NCT02875236 Phase 4 OctaplasLG®;Ringer-acetat
10 Efficacy and Safety of Unfractionated Heparin on Severe Sepsis With Suspected Disseminated Intravascular Coagulation Unknown status NCT02654561 Phase 3 Heparin Sodium;Saline
11 The Effect of Ulinastatin on Bronchoalveolar Lavage Fluid of Inflammatory Factors in Patients With Ventilator-associated Pneumonia Unknown status NCT01865266 Phase 2, Phase 3 Ulinaststin for injection;placebo
12 An Open-label Study of KW-3357 Completed NCT01384903 Phase 3 KW-3357;Plasma-derived antithrombin
13 A Clinical Study of KW-3357 in Patients With DIC Completed NCT01384396 Phase 3 KW-3357
14 Impact of Low Dose Unfractionated Heparin Treatment on Inflammation in Sepsis Completed NCT02135770 Phase 3 Unfractionated heparin
15 Heparin Binding Protein in Patients With Acute Respiratory Failure Treated With GCSF (Filgrastim) Completed NCT01713309 Phase 2, Phase 3 Filgrastim
16 Comparison of Topical and Intravenous Tranexamic Acid in Total Hip Arthroplasty Completed NCT02312440 Phase 3 0.9% sodium chloride;tranexamic acid;tranexamic acid
17 Comparison of Topical Versus Intravenous Tranexamic Acid in TKA Completed NCT02393300 Phase 3 normal saline;Tranexamic Acid;Tranexamic Acid
18 Bronchiolitis in Infants Placebo Versus Dexamethasone Study Recruiting NCT03567473 Phase 3 Oral dexamethasone;Nebulized Epinephrine;Oral placebo;Nebulized normal saline
19 Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic Leukemia Recruiting NCT02339740 Phase 3 Arsenic Trioxide;Cytarabine;Dexamethasone;Idarubicin;Mitoxantrone Hydrochloride;Tretinoin
20 Detection of False Positives From First-trimester Preeclampsia Screening (StopPRE) at the Second-trimester of Pregnancy Not yet recruiting NCT03741179 Phase 3 ASA-withdrawn group
21 A Phase 3 Clinical Study of KW-3357 in Patients With DIC Terminated NCT01384409 Phase 3 KW-3357
22 A Phase III Efficacy and Safety Study of Intravenous Retosiban Versus Placebo for Women in Spontaneous Preterm Labor Terminated NCT02377466 Phase 3 Retosiban IV infusion;Placebo IV infusion
23 A Randomized Study Comparing the Efficacy and Safety of Retosiban Versus Atosiban for Women in Spontaneous Preterm Labour Terminated NCT02292771 Phase 3 Retosiban;Atosiban;Placebo matching retosiban;Placebo matching atosiban
24 Safety and Efficacy of ART-123 in Subjects With Sepsis and Disseminated Intravascular Coagulation Completed NCT00487656 Phase 2 ART-123;placebo
25 GR270773 In The Treatment Of Suspected Or Confirmed Gram-Negative Severe Sepsis In Adults Completed NCT00089986 Phase 2 Intravenous GR270773- Phospholipid Emulsion
26 Recombinant Vaccinia Virus Administered Intravenously in Patients With Metastatic, Refractory Colorectal Carcinoma Completed NCT01394939 Phase 1, Phase 2 Irinotecan
27 Safety and Efficacy of the ONCOlytic VIRus Armed for Local Chemotherapy, TG6002/5-FC, in Recurrent Glioblastoma Patients Recruiting NCT03294486 Phase 1, Phase 2 Combination of TG6002 and 5-flucytosine (5-FC, Ancotil®)
28 Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock (SHOCK) Trial Recruiting NCT03092245 Phase 2 OctaplasLG;Ringer-Acetate
29 Recombinant Human Antithrombin (ATryn®) in the Treatment of Patients With DIC Associated With Severe Sepsis Terminated NCT00506519 Phase 2 antithrombin alfa (INN name)
30 4G/5G Polymorphism of Plasminogen Activator Inhibitor-1 Gene and Disseminated Intravascular Coagulation in Severe Sepsis and Septic Shock Unknown status NCT01211899
31 Interest of the Balance of Pro-coagulating and Profibrinolytis Activities of the Microparticles (MP) in the Prognosis of Septic Shock Unknown status NCT02062970 Not Applicable
32 Oxidative Stress and Endothelial Function in Pregnancy Complications Unknown status NCT02603913
33 IMproved PRegnancy Outcome by Early Detection Unknown status NCT01891240
34 Coagulation Factor Changes Associated With Postpartum Hysterectomies Completed NCT00456547
35 Role of the Circulating Procoagulants Microparticles in the Hypercoagulability of MNP Ph1- Completed NCT02862366
36 Study of New Biological Markers for Prediction of Severe Acute Pancreatitis Completed NCT00786591
37 TC-325 (HEMOSPRAY™) VS. CURRENT STANDARD OF CARE IN MANAGING MALIGNANT GASTROINTESTINAL BLEEDING: A PILOT STUDY TO INFORM A RANDOMIZED CONTROLLED TRIAL. Completed NCT02135627 Not Applicable TC-325 monotherapy on initial endoscopy ± radiation therapy, angioembolization, and/or surgery.
38 Correlation Between Cytokines and the Severity of Meningococcal Disease Completed NCT01133834
39 Platelet Reactivity in Septic Shock Completed NCT03716310
40 The Use of the Bakri Postpartum Balloon in the Management of Postpartum Hemorrhage Refractory to Conservative Measures Completed NCT01844089
41 Impact of Monitoring Quality Indicators in Maternity Departments on Mother and Infant Health Completed NCT01459978
42 The Procalcitonin and Survival Study Completed NCT00271752 Not Applicable
43 Retrospective Longitudinal Study of Gestational Weight Gain Among Chinese Pregnant Women Completed NCT03154268
44 International Prospective Registry of Disseminated Intravascular Coagulation Recruiting NCT03577015
45 Thromboelastometry Guided DIC Prevention After Cesarean Section in Pregnant Women With Placenta Previa Recruiting NCT03266432 Not Applicable
46 Rotational Thromboelastometry for the Transfusion Management of Postpartum Hemorrhage After Vaginal or Cesarean Delivery Recruiting NCT03064152 Not Applicable
47 Evaluation of Endothelial Dysfunction During Aortic Valvular Replacement by Bioprosthesis With and Without Extracorporeal Circulation Recruiting NCT03135496
48 Hypercoagulation Screening in Cancer Recruiting NCT02622815
49 Randomizated Open-label Control Trial to Evaluate if the Incorporation of sFlt1/PlGF Ratio in the Diagnosis and Classification of PE Improves Maternal and Perinatal Outcomes in Women With the Suspicion of the Disease Recruiting NCT03231657 Not Applicable
50 Patient Blood Management for Massive Obstetric Hemorrhage Recruiting NCT03784794 Not Applicable Fibrinogen Concentrate Human;Prothrombin Complex Concentrates

Search NIH Clinical Center for Disseminated Intravascular Coagulation

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: disseminated intravascular coagulation

Genetic Tests for Disseminated Intravascular Coagulation

Genetic tests related to Disseminated Intravascular Coagulation:

# Genetic test Affiliating Genes
1 Disseminated Intravascular Coagulation 29

Anatomical Context for Disseminated Intravascular Coagulation

MalaCards organs/tissues related to Disseminated Intravascular Coagulation:

Skin, Liver, Lung, Prostate, Bone, Endothelial, Heart

Publications for Disseminated Intravascular Coagulation

Articles related to Disseminated Intravascular Coagulation:

(show top 50) (show all 1287)
# Title Authors Year
Risk factors for disseminated intravascular coagulation in patients with lung cancer. ( 29851300 )
Prediction of Disseminated Intravascular Coagulation by Liver Function Tests in Patients with Japanese Spotted Fever. ( 29021432 )
Clinical characteristics of disseminated intravascular coagulation in patients with solid and hematological cancers. ( 29703488 )
Management of disseminated intravascular coagulation: current insights on antithrombin and thrombomodulin treatments. ( 29343993 )
Genistein has the function of alleviating and treating disseminated intravascular coagulation caused by lipopolysaccharide. ( 29761425 )
Screening itself for disseminated intravascular coagulation may reduce mortality in sepsis: A nationwide multicenter registry in Japan. ( 29202320 )
Enterohemorrhagic colitis with disseminated intravascular coagulation. ( 29904297 )
How I treat disseminated intravascular coagulation. ( 29255070 )
<i>ALK</i>-Negative Anaplastic Large Cell Lymphoma Presenting as Disseminated Intravascular Coagulation and Hemophagocytic Lymphohistiocytosis: A Potentially Fatal Presentation. ( 29850298 )
Newly Proposed Sepsis-Induced Coagulopathy Precedes International Society on Thrombosis and Haemostasis Overt-Disseminated Intravascular Coagulation and Predicts High Mortality. ( 29720054 )
Pathogenesis and diagnosis of disseminated intravascular coagulation. ( 29741245 )
Thrombotic and hemorrhagic complications during visceral transplantation: risk factors, and association with intraoperative disseminated intravascular coagulation-like thromboelastographic qualities: a single-center retrospective study. ( 29786890 )
Bilateral orbital compartment syndrome in a patient with disseminated intravascular coagulation. ( 29308942 )
International Normalized Ratio Relevance to the Observed Coagulation Abnormalities in Warfarin Treatment and Disseminated Intravascular Coagulation. ( 29848060 )
Clinical Impact of Recombinant Soluble Thrombomodulin for Disseminated Intravascular Coagulation Associated with Severe Acute Cholangitis. ( 29699063 )
Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways. ( 29921614 )
Machine learning-based diagnosis for disseminated intravascular coagulation (DIC): Development, external validation, and comparison to scoring systems. ( 29718941 )
A rare variant of t(17;19) in a case of Philadelphia positive adult acute lymphoblastic leukemia presenting with disseminated intravascular coagulation. ( 29662872 )
Antithrombin concentrate use in disseminated intravascular coagulation of sepsis: meta-analyses revisited. ( 29316235 )
Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies-what intensivists need to know. ( 29895296 )
Recombinant Thrombomodulin Used to Successfully Treat Cronkhite-Canada Syndrome with Disseminated Intravascular Coagulation due to Sepsis in a Compromised Patient: A Case Report. ( 29877275 )
The disseminated intravascular coagulation score is a novel predictor for portal vein thrombosis in cirrhotic patients with hepatitis B. ( 29178991 )
A summary of the Japan septic disseminated intravascular coagulation study. ( 29657722 )
No impact of disseminated intravascular coagulation in kidney donors on long-term kidney transplantation outcome: A multicenter propensity-matched study. ( 29981217 )
Successful management of obstetric disseminated intravascular coagulation using a portable fibrinogen-measuring device. ( 29359377 )
Disseminated intravascular coagulation: is it fact or fancy? ( 29621007 )
Antithrombin concentrate use in sepsis-associated disseminated intravascular coagulation: re-evaluation of a 'pendulum effect' drug using a nationwide database. ( 29316251 )
Evaluation of disseminated intravascular coagulation scores in critically ill pediatric patients with septic shock. ( 29940405 )
Delayed disseminated intravascular coagulation revealed by spontaneous hematomas after conservative treatment of placenta percreta. ( 29804883 )
Efficacy of Combined Thrombomodulin and Antithrombin in Anticoagulant Therapy for Acute Cholangitis-induced Disseminated Intravascular Coagulation. ( 30449812 )
Disseminated Intravascular Coagulation in a Patient with Advanced Lung Adenocarcinoma. ( 30368413 )
Menstruation-related disseminated intravascular coagulation in an adenomyosis patient: case report and review of the literature. ( 30044152 )
Disseminated Intravascular Coagulation After Embolization to Treat Acutely Bleeding Bilateral Massive Angiomyolipoma: A Case Report. ( 30065960 )
Management of disseminated intravascular coagulation in a patient with hepatic angiosarcoma: A case report. ( 30461646 )
Disseminated Intravascular Coagulation and Acute Liver Injury from Ethanol Embolization of an Arteriovenous Malformation. ( 29455883 )
A Proposal of the Modification of Japanese Society on Thrombosis and Hemostasis (JSTH) Disseminated Intravascular Coagulation (DIC) Diagnostic Criteria for Sepsis-Associated DIC. ( 28747069 )
Successful Resuscitation of Maternal Cardiac Arrest With Disseminated Intravascular Coagulation Guided by Rotational Thromboelastometry and Transesophageal Echocardiography: A Case Report. ( 29077660 )
Impact of non-anticoagulant therapy on patients with sepsis-induced disseminated intravascular coagulation: A multicenter, case-control study. ( 29329022 )
Concomitant Versus Individual Administration of Antithrombin and Thrombomodulin for Sepsis-Induced Disseminated Intravascular Coagulation: A Nationwide Japanese Registry Study. ( 29471674 )
Whole genome analysis of a multidrug-resistant Streptococcus pneumoniae isolate from a patient with invasive pneumococcal infection developing disseminated intravascular coagulation. ( 29496334 )
Retrospective analysis on the clinical outcomes of recombinant human soluble thrombomodulin for disseminated intravascular coagulation syndrome associated with solid tumors. ( 29511940 )
Optimal Antithrombin Activity Threshold for Initiating Antithrombin Supplementation in Patients With Sepsis-Induced Disseminated Intravascular Coagulation: A Multicenter Retrospective Observational Study. ( 29514467 )
Platelet function in disseminated intravascular coagulation: A systematic review. ( 29517400 )
Evaluation of the diagnostic utility of individual parameters in the disseminated intravascular coagulation (DIC) panel for use in underresourced settings. ( 29532646 )
Clinical Investigation of Coagulation Markers for Early Detection of Sepsis-Induced Disseminated Intravascular Coagulation: A Single-Center, Prospective Observational Study. ( 29552913 )
Disseminated intravascular coagulation: an update on pathogenesis and diagnosis. ( 29999440 )
Differences and similarities between disseminated intravascular coagulation and thrombotic microangiopathy. ( 30008620 )
Comparison of a new criteria for sepsis-induced coagulopathy and International Society on Thrombosis and Haemostasis disseminated intravascular coagulation score in critically ill patients with sepsis 3.0: a retrospective study. ( 30015646 )
Radical treatment of primary type B aortic dissection or after thoracic endovascular aortic repair to manage disseminated intravascular coagulation. ( 30069381 )
Performance of 5 disseminated intravascular coagulation score systems in predicting mortality in patients with severe trauma. ( 30113490 )

Variations for Disseminated Intravascular Coagulation

Expression for Disseminated Intravascular Coagulation

Search GEO for disease gene expression data for Disseminated Intravascular Coagulation.

Pathways for Disseminated Intravascular Coagulation

Pathways related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
12.97 F2 F3 F5 F7 F9 FGA
Show member pathways
12.58 F2 F3 F5 F7 F9 FGA
Show member pathways
4 11.84 F2 F3 F5 F7 F9 FGA
Show member pathways
11.67 F2 F7 F9
Show member pathways
11.57 F2 F3 F5 F7 F9 FGA
8 10.72 F2 F7 F9

GO Terms for Disseminated Intravascular Coagulation

Cellular components related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.93 ADAMTS13 ELANE F2 F3 F5 F7
2 cell surface GO:0009986 9.87 ADAMTS13 ELANE F3 FGA PLAT SERPINF2
3 endoplasmic reticulum lumen GO:0005788 9.8 ADAMTS13 F2 F5 F7 F9 FGA
4 blood microparticle GO:0072562 9.76 F2 FGA SERPINC1 SERPINF2
5 platelet alpha granule lumen GO:0031093 9.71 F5 FGA SERPINE1 SERPINF2
6 Golgi lumen GO:0005796 9.67 F2 F7 F9
7 platelet alpha granule GO:0031091 9.51 F5 FGA
8 collagen-containing extracellular matrix GO:0062023 9.5 ELANE F3 FGA PLAT SERPINC1 SERPINE1
9 fibrinogen complex GO:0005577 9.48 FGA SERPINF2
10 extracellular space GO:0005615 9.44 ADAMTS13 ELANE F2 F3 F5 F7
11 serine-type peptidase complex GO:1905286 9.43 F3 F7
12 plasma membrane GO:0005886 10.22 F2 F3 F5 F7 F9 FGA
13 extracellular exosome GO:0070062 10.07 ELANE F2 F9 FGA MB PIK3C2A

Biological processes related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.91 ADAMTS13 ELANE F2 F7 F9 PLAT
2 cellular protein metabolic process GO:0044267 9.84 F2 F5 FGA SERPINC1
3 ER to Golgi vesicle-mediated transport GO:0006888 9.8 F2 F5 F7 F9
4 negative regulation of endopeptidase activity GO:0010951 9.79 SERPINC1 SERPINE1 SERPINF2
5 negative regulation of peptidase activity GO:0010466 9.79 SERPINC1 SERPINE1 SERPINF2
6 platelet activation GO:0030168 9.77 ADAMTS13 F2 FGA
7 protein processing GO:0016485 9.69 ADAMTS13 F3 F7
8 platelet degranulation GO:0002576 9.67 F5 FGA SERPINE1 SERPINF2
9 blood coagulation GO:0007596 9.65 ADAMTS13 F2 F3 F5 F7 F9
10 negative regulation of proteolysis GO:0045861 9.63 F2 PLAT
11 positive regulation of collagen biosynthetic process GO:0032967 9.62 F2 SERPINF2
12 blood coagulation, intrinsic pathway GO:0007597 9.61 F2 F9
13 negative regulation of blood coagulation GO:0030195 9.6 SERPINE1 THBD
14 regulation of blood coagulation GO:0030193 9.58 F2 SERPINC1
15 positive regulation of positive chemotaxis GO:0050927 9.58 F3 F7
16 plasminogen activation GO:0031639 9.57 FGA PLAT
17 negative regulation of platelet activation GO:0010544 9.56 F2 THBD
18 negative regulation of fibrinolysis GO:0051918 9.56 F2 SERPINE1 SERPINF2 THBD
19 acute inflammatory response to antigenic stimulus GO:0002438 9.55 ELANE SERPINC1
20 fibrinolysis GO:0042730 9.55 F2 FGA PLAT SERPINE1 SERPINF2
21 negative regulation of plasminogen activation GO:0010757 9.52 SERPINE1 SERPINF2
22 positive regulation of blood coagulation GO:0030194 9.5 F2 F7 SERPINE1
23 blood coagulation, extrinsic pathway GO:0007598 9.48 F3 F7
24 positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 9.46 F3 F7
25 neutrophil mediated killing of gram-negative bacterium GO:0070945 9.4 ELANE F2
26 hemostasis GO:0007599 9.28 ADAMTS13 F2 F3 F5 F7 F9

Molecular functions related to Disseminated Intravascular Coagulation according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.83 ADAMTS13 F2 F7 F9 THBD
2 peptidase activity GO:0008233 9.73 ADAMTS13 ELANE F2 F7 F9 PLAT
3 signaling receptor binding GO:0005102 9.72 F2 F7 FGA PLAT SERPINE1
4 heparin binding GO:0008201 9.65 ELANE F2 SERPINC1
5 peptidase inhibitor activity GO:0030414 9.63 SERPINC1 SERPINE1 SERPINF2
6 serine-type endopeptidase inhibitor activity GO:0004867 9.58 SERPINC1 SERPINE1 SERPINF2
7 serine-type peptidase activity GO:0008236 9.55 ELANE F2 F7 F9 PLAT
8 endopeptidase activity GO:0004175 9.54 ELANE F7 F9
9 serine-type endopeptidase activity GO:0004252 9.43 ELANE F2 F3 F7 F9 PLAT
10 protease binding GO:0002020 9.02 ELANE F3 SERPINC1 SERPINE1 SERPINF2
11 protein binding GO:0005515 10.31 ADAMTS13 ELANE F2 F3 F5 F7

Sources for Disseminated Intravascular Coagulation

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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