PNES
MCID: DSS025
MIFTS: 26

Dissociative Seizures (PNES)

Categories: Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Dissociative Seizures

MalaCards integrated aliases for Dissociative Seizures:

Name: Dissociative Seizures 52
Dissociative Convulsions 71 32
Psychogenic Nonepileptic Seizures 52
Non-Epileptic Attack Disorder 52
Psychogenic Seizures 52
Functional Seizures 52
Psychogenic Seizure 71
Pseudoseizures 52
Pnes 52

Classifications:



External Ids:

ICD10 32 F44.5
UMLS 71 C0349245 C1142430

Summaries for Dissociative Seizures

NIH Rare Diseases : 52 Dissociative or psychogenic nonepileptic seizures (PNES) are involuntary episodes of movement, sensation, or behaviors (vocalizations, crying, and other expressions of emotion) that do not result from abnormal brain discharges. The seizures can look like any kind of epileptic seizure. They are somatic manifestations (physical symptoms) of psychologic distress. Psychiatric conditions associated with PNES include depression, anxiety, somatoform disorder , posttraumatic stress disorder , dissociative disorder , and personality disorders . Treatment depends on the cause of the psychologic distress, and may involve cognitive behavioral therapy or psychotherapy , as well as antidepressive medication.

MalaCards based summary : Dissociative Seizures, also known as dissociative convulsions, is related to ewing sarcoma and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, and has symptoms including seizures The drugs Sertraline and Serotonin Uptake Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include brain, amygdala and spinal cord.

Wikipedia : 74 Psychogenic non-epileptic seizures (PNES) are events resembling an epileptic seizure, but without the... more...

Related Diseases for Dissociative Seizures

Diseases related to Dissociative Seizures via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 ewing sarcoma 11.3
2 diffuse idiopathic pulmonary neuroendocrine cell hyperplasia 11.2
3 pudendal neuralgia 11.2
4 neuronal migration disorders 10.8
5 movement disease 10.4
6 visual epilepsy 10.4
7 seizure disorder 10.4
8 stuttering 10.4
9 psychotic disorder 10.4
10 traumatic brain injury 10.4
11 low compliance bladder 10.4
12 generalized anxiety disorder 10.3
13 disease of mental health 10.3
14 47,xyy 10.3
15 dissociative disorder 10.3
16 status epilepticus 10.3
17 mood disorder 10.3
18 alacrima, achalasia, and mental retardation syndrome 10.2
19 neurogenic bladder 10.2
20 borderline personality disorder 10.2
21 factitious disorder 10.2
22 attention deficit-hyperactivity disorder 10.1
23 autism 10.1
24 persistent mullerian duct syndrome, types i and ii 10.1
25 schizophrenia 6 10.1
26 inflammatory bowel disease 10.1
27 persistent mullerian duct syndrome 10.1
28 autism spectrum disorder 10.1
29 aphasia 10.1
30 allergic hypersensitivity disease 10.1
31 eclampsia 10.1
32 encephalomalacia 10.1
33 craniosynostosis 10.1
34 toxic encephalopathy 10.1
35 insulinoma 10.1
36 brain injury 10.1
37 fainting 10.1
38 headache 10.1
39 substance abuse 10.1
40 bipolar disorder 10.1
41 somatoform disorder 10.1
42 panic disorder 10.1
43 severe combined immunodeficiency 10.1
44 syncope 10.1
45 major depressive disorder 10.1
46 mental depression 10.1
47 fibromyalgia 10.1
48 chronic fatigue syndrome 10.1
49 depression 10.1
50 chronic pain 10.1

Graphical network of the top 20 diseases related to Dissociative Seizures:



Diseases related to Dissociative Seizures

Symptoms & Phenotypes for Dissociative Seizures

UMLS symptoms related to Dissociative Seizures:


seizures

Drugs & Therapeutics for Dissociative Seizures

Drugs for Dissociative Seizures (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sertraline Approved Phase 4 79617-96-2 68617
2 Serotonin Uptake Inhibitors Phase 4
3 Serotonin Agents Phase 4
4 Antidepressive Agents Phase 4
5
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
6
Caffeine Approved 58-08-2 2519
7 Psychotropic Drugs
8 Neurotransmitter Agents
9 Central Nervous System Stimulants
10 Phosphodiesterase Inhibitors

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Medication and Psychotherapy Treatment Trial for Psychogenic Nonepileptic Seizures Completed NCT00835627 Phase 4 sertraline
2 Treatment for Psychogenic Nonepileptic Seizures: A Pilot, 12 Week, Prospective, Randomized, Placebo-controlled, Double-blind, Clinical Trial of Sertraline in the Treatment of Comorbid Psychiatric Disorders in NES Completed NCT00159965 Phase 4 sertraline;placebo
3 Assessment and Prognostic Factors of Quality of Life in Patients With Psychogenic Nonepileptic Seizures Unknown status NCT02821208
4 Cognitive Behavioural Therapy in Dissociative Seizures: A Randomised Controlled Trial Unknown status NCT00688727
5 Evaluation d'un Dispositif de Suivi téléphonique Sur la Qualité de Vie Dans Les Crises Psychogènes Non Epileptiques. Unknown status NCT02311829
6 COgnitive Behavioural Therapy Versus Standardised Medical Care for Adults With Dissociative Non-Epileptic Seizures: A Multicentre Randomised Controlled Trial (CODES) Completed NCT02325544
7 Motivational Interviewing to Enhance Adherence of Patients With Psychogenic Non-epileptic Seizures: A Model of Patient Engagement in Functional Neurological Symptom Disorders Completed NCT02598076
8 Neuroimaging Biomarker for Seizures Recruiting NCT03441867
9 Pilot Study of Cognitive Behavioral Therapy-Informed Physical Therapy Intervention in Functional Neurological Disorders Recruiting NCT03731078
10 The Feasibility of Project UPLIFT for the Treatment of Psychogenic Non-Epileptic Seizures Recruiting NCT03329703
11 Neuroimaging Biomarkers of Prognosis in Motor Functional Neurological Disorders Recruiting NCT03398070
12 Treatment Outcomes of Cognitive-behavioral Therapy for Psychogenic Non-epileptic Seizures (PNES) Recruiting NCT02801136
13 VECU EMOTIONNEL CHEZ LES PATIENTES SOUFFRANT DE CRISES NON EPILEPTIQUES PSYCHOGENES : ETUDE EN IMAGERIE PAR RESONANCE MAGNETIQUE FONCTIONNELLE-ETUDE EMOCRISES Recruiting NCT02976545
14 Safety and Feasibility of Virtual Reality Therapy for Functional Neurological Symptom/Conversion Disorder Recruiting NCT02764476
15 Neurobiological Studies of Functional Movement Disorders and Non-Epileptic Seizures Recruiting NCT00500994
16 Automated Identification of Psychogenic Nonepileptic Seizures Active, not recruiting NCT03013348
17 Detecting PNES With Single-channel sEMG Active, not recruiting NCT03313362
18 An Exploratory Trial Using sEMG to Differentiate PNES From Epileptic Seizures Active, not recruiting NCT03169751
19 The Efficacy of Transcranial Magnetic Stimulation in the Treatment of Non-epileptic Seizures Enrolling by invitation NCT02796924

Search NIH Clinical Center for Dissociative Seizures

Genetic Tests for Dissociative Seizures

Anatomical Context for Dissociative Seizures

MalaCards organs/tissues related to Dissociative Seizures:

40
Brain, Amygdala, Spinal Cord, Heart, Temporal Lobe, Tongue

Publications for Dissociative Seizures

Articles related to Dissociative Seizures:

(show all 41)
# Title Authors PMID Year
1
International multicenter studies on psychogenic nonepileptic seizures: A systematic review. 61
32014624 2020
2
Predicting first attendance at psychiatry appointments in patients with dissociative seizures. 61
31869756 2020
3
Reduced left amygdala volume in patients with dissociative seizures (psychogenic nonepileptic seizures). 61
31874358 2019
4
The aetiology of psychogenic non-epileptic seizures: risk factors and comorbidities. 61
31843732 2019
5
Characteristics of 698 patients with dissociative seizures: A UK multicenter study. 61
31608436 2019
6
What are non-epileptic seizures, and why do people have them? 61
31707888 2019
7
Impaired emotional and behavioural awareness and control in patients with dissociative seizures. 61
31625504 2019
8
A tiered strategy for investigating status epilepticus. 61
31706706 2019
9
Neurologists' experiences of participating in the CODES study-A multicentre randomised controlled trial comparing cognitive behavioural therapy vs standardised medical care for dissociative seizures. 61
31158560 2019
10
Dissociative (non-epileptic) seizures: tackling common challenges after the diagnosis. 61
30878972 2019
11
Explaining dissociative seizures: a neuropsychological perspective. 61
30755460 2019
12
Exploring psychiatrists' perspectives of working with patients with dissociative seizures in the UK healthcare system as part of the CODES trial: a qualitative study. 61
31072856 2019
13
Abnormal sleep in patients with epileptic or dissociative (non-epileptic) seizures: a polysomnography study. 61
30168895 2019
14
A case of dissociative convulsions presented as frequent epilepsy-like seizures. 61
31552382 2019
15
Functional neurological disorders: acute presentations and management. 61
30287439 2018
16
Emergency hospital care for adults with suspected seizures in the NHS in England 2007-2013: a cross-sectional study. 61
30344177 2018
17
Research on dissociative seizures: A bibliometric analysis and visualization of the scientific landscape. 61
29705627 2018
18
Autonomic and subjective responsivity to emotional images in people with dissociative seizures. 61
29285879 2018
19
A Case of Dissociative Seizures Presented like Myoclonic Epilepsy. 61
29736136 2018
20
Implicit attentional bias for facial emotion in dissociative seizures: Additional evidence. 61
29402630 2018
21
[Differential diagnosis of dissociative seizures]. 61
28871346 2017
22
COgnitive behavioural therapy versus standardised medical care for adults with Dissociative non-Epileptic Seizures (CODES): statistical and economic analysis plan for a randomised controlled trial. 61
28587649 2017
23
Dissociation in patients with dissociative seizures: relationships with trauma and seizure symptoms. 61
28065191 2017
24
Response to eperisone in patients of therapy-resistant dissociative convulsions: A report of two cases. 61
28458436 2017
25
Explicit Facial Emotion Processing in Patients With Dissociative Seizures. 61
27187848 2016
26
Functional Disorders in Neurology: Case Studies. 61
27445247 2016
27
Emotion and dissociative seizures: A phenomenological analysis of patients' perspectives. 61
26799918 2016
28
Dissociative seizures--a critical review and perspective. 61
24090778 2013
29
Dissociative seizures: a challenge for neurologists and psychotherapists. 61
23667393 2013
30
[Dissociative seizures: a manual for neurologists for communicating the diagnosis]. 61
22328103 2013
31
[Assessment and treatment of patients with nonepileptic dissociative seizures in a department of epileptology]. 61
21971696 2011
32
Dissociative disorders in a psychiatric institute in India--a selected review and patterns over a decade. 61
19762410 2010
33
[Dissociative seizures: a diagnostic and therapeutic challenge on the borderline between psychiatry and neurology]. 61
19039572 2009
34
[When patients can not tell you what is bothering them--the impossibility of explicite communication with patients suffering from conversion disorder]. 61
18214209 2007
35
Behavior therapy in dissociative convulsions disorder. 61
16756783 2006
36
Ictal symptoms of anxiety, avoidance behaviour, and dissociation in patients with dissociative seizures. 61
16614021 2006
37
The approach to patients with "non-epileptic seizures". 61
16085740 2005
38
An evaluation of cognitive behavioral therapy as a treatment for dissociative seizures: a pilot study. 61
15209224 2004
39
[Dissociative convulsions]. 61
12877038 2003
40
Dissociative disorders in the Sultanate of Oman. 61
11008853 2000
41
Limited utility of ICD-10 and DSM-IV classification of dissociative and conversion disorders in India. 61
9111849 1997

Variations for Dissociative Seizures

Expression for Dissociative Seizures

Search GEO for disease gene expression data for Dissociative Seizures.

Pathways for Dissociative Seizures

GO Terms for Dissociative Seizures

Sources for Dissociative Seizures

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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