MCID: DSS006
MIFTS: 23

Disuse Amblyopia

Categories: Neuronal diseases

Aliases & Classifications for Disuse Amblyopia

MalaCards integrated aliases for Disuse Amblyopia:

Name: Disuse Amblyopia 12 15
Stimulus Deprivation Amblyopia 70
Deprivation Amblyopia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10378
ICD9CM 34 368.02
SNOMED-CT 67 193638002
ICD10 32 H53.01
UMLS 70 C0152189

Summaries for Disuse Amblyopia

MalaCards based summary : Disuse Amblyopia, also known as stimulus deprivation amblyopia, is related to amblyopia and esotropia. An important gene associated with Disuse Amblyopia is CRYAA (Crystallin Alpha A). Affiliated tissues include eye.

Related Diseases for Disuse Amblyopia

Diseases related to Disuse Amblyopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 amblyopia 30.6 PITX3 FOXE3 CRYGS CRYAA
2 esotropia 30.2 LCA5L FOXE3 CRYAA
3 cataract 29.4 TDRD7 PITX3 FYCO1 FOXE3 CRYGS CRYAA
4 suppression amblyopia 10.8
5 strabismus 10.3
6 mechanical strabismus 10.3
7 morgagni cataract 10.3 CRYGS CRYAA
8 early-onset lamellar cataract 10.3 CRYGS CRYAA
9 mature cataract 10.2 CRYGS CRYAA
10 retinal perforation 10.2 CRYGS CRYAA
11 presbyopia 10.2 CRYGS CRYAA
12 galactosemia ii 10.2 CRYGS CRYAA
13 congenital aphakia 10.2 FOXE3 CRYAA
14 cataract 44 10.2 FYCO1 CRYAA
15 monocular esotropia 10.2
16 refractive error 10.2
17 early-onset nuclear cataract 10.1 FYCO1 CRYAA
18 diabetic cataract 10.1 CRYGS CRYAA
19 sclerocornea 10.1 FOXE3 CRYAA
20 chronic closed-angle glaucoma 10.1 SPATA31A3 FOXE3
21 ocular dominance 10.1
22 ptosis 10.1
23 cycloplegia 10.1
24 anisometropia 10.1
25 pathologic nystagmus 10.1
26 senile cataract 10.1 CRYGS CRYAA
27 eye accommodation disease 10.1 FOXE3 CRYGS CRYAA
28 frontotemporal dementia and/or amyotrophic lateral sclerosis 7 10.1 CHMP4B CHMP4A
29 primary congenital glaucoma 10.0 FOXE3 CRYAA
30 cataract 32, multiple types 10.0 CRYAA CHMP4B CHMP4A
31 cataract 6, multiple types 10.0 CRYAA CHMP4B CHMP4A
32 cataract 31, multiple types 10.0 CRYAA CHMP4B CHMP4A
33 ayme-gripp syndrome 10.0 PITX3 CRYAA
34 yemenite deaf-blind hypopigmentation syndrome 9.9
35 astigmatism 9.9
36 congenital ptosis 9.9
37 alternating exotropia 9.9
38 exotropia 9.9
39 farsightedness 9.9
40 persistent hyperplastic primary vitreous 9.9 FOXE3 CRYGS
41 early-onset posterior polar cataract 9.9 PITX3 CHMP4B
42 aniseikonia 9.9 PITX3 FOXE3
43 anterior segment dysgenesis 2 9.9 PITX3 FOXE3
44 posterior polar cataract 9.8 PITX3 CRYAA CHMP4B
45 axenfeld-rieger syndrome, type 1 9.8 PITX3 FOXE3 CRYAA
46 iris disease 9.8 PITX3 FOXE3 CRYAA
47 aniridia 1 9.8 PITX3 FOXE3 CRYAA
48 anterior segment dysgenesis 1 9.8 PITX3 FOXE3
49 coloboma of macula 9.7 PITX3 FOXE3 CRYAA
50 peters-plus syndrome 9.7 PITX3 FOXE3 CRYAA

Graphical network of the top 20 diseases related to Disuse Amblyopia:



Diseases related to Disuse Amblyopia

Symptoms & Phenotypes for Disuse Amblyopia

Drugs & Therapeutics for Disuse Amblyopia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Optical Coherence Tomography Angiography Analysis After Childhood Lensectomy Recruiting NCT04217772

Search NIH Clinical Center for Disuse Amblyopia

Genetic Tests for Disuse Amblyopia

Anatomical Context for Disuse Amblyopia

MalaCards organs/tissues related to Disuse Amblyopia:

40
Eye

Publications for Disuse Amblyopia

Articles related to Disuse Amblyopia:

(show all 47)
# Title Authors PMID Year
1
Prevalence and pattern of amblyopia in a rural hospital in Ghana. 61
32627626 2020
2
Occlusion for stimulus deprivation amblyopia. 61
32203629 2020
3
Prevalence of amblyopia in Bulgaria. 61
30325246 2018
4
Occlusion for stimulus deprivation amblyopia. 61
24504975 2014
5
Prevalence and etiology of amblyopia in Southern India: results from screening of school children aged 5-15 years. 61
23865603 2013
6
[Functional amblyopia]. 61
24844030 2013
7
Congenital ptosis and amblyopia. 61
20349903 2010
8
Refractive error, strabismus and amblyopia in congenital ptosis. 61
21180220 2010
9
Charlie Brown, amblyopia, and me: A (not so short) personal history of the past forty years of diagnosing and treating amblyopia. 61
21061887 2010
10
Assessing amblyogenic factors in 100 patients with congenital ptosis. 61
22553585 2010
11
Causes of amblyopia in children coming to ophthalmology out patient department Khyber Teaching Hospital, Peshawar. 61
18517116 2008
12
The use of reinforced adhesive tape in supporting pendulous upper eyelid lesions. 61
17452849 2007
13
Interventions for stimulus deprivation amblyopia. 61
16856079 2006
14
Visual outcome of cataract surgery in children with congenital rubella syndrome. 61
12736620 2003
15
Congenital ptosis and amblyopia: a retrospective study of 130 cases. 61
12148555 2002
16
The present and potential impact of research on animal models for clinical treatment of stimulus deprivation amblyopia. 61
11952391 2002
17
Stimulus deprivation amblyopia in human congenital ptosis: a study of 100 patients. 61
11262686 2000
18
[Visual evoked potentials in patients with refraction amblyopia in the presence of high myopia]. 61
9148557 1996
19
[Amblyopia, refractive errors and strabismus in congenital ptosis]. 61
8963129 1996
20
Modulation of amblyopia therapy following early surgery for unilateral congenital cataracts. 61
7488596 1995
21
Small and large field grating acuity versus recognition acuity in different groups of amblyopic patients. 61
21314519 1994
22
Corticosteroids in the management of adnexal hemangiomas in infancy and childhood. 61
1543320 1992
23
Amblyopia and strabismus in congenital ptosis. 61
3256499 1988
24
A comparison of the spectral sensitivities of monkeys with anisometropic and stimulus deprivation amblyopia. 61
3790234 1986
25
Central and peripheral residual vision in humans with bilateral deprivation amblyopia. 61
3709711 1986
26
Preferential looking grating acuities of infants at risk of amblyopia. 61
3868885 1985
27
Stimulus deprivation amblyopia in children. Sensitivity, plasticity, and elasticity (SPE). 61
6743080 1984
28
Stimulus deprivation amblyopia. Simultaneous recording of local macular electroretinogram and visual evoked response. 61
6743095 1984
29
Effects of enucleation of the nondeprived eye on stimulus deprivation amblyopia in monkeys. 61
6698724 1984
30
Cataracts and ketotic hypoglycemia. 61
7177578 1982
31
Perforating injuries of cornea and sclera. 61
6763391 1982
32
Prentice-Memorial Lecture: Is the animal model for stimulus deprivation amblyopia in children valid or useful? 61
6808843 1982
33
Psychophysical investigations of the temporal modulation sensitivity function in amblyopia: uniform field flicker. 61
7061220 1982
34
New clinical aspects of stimulus deprivation amblyopia. 61
7294102 1981
35
Behavioral studies of stimulus deprivation amblyopia in monkeys. 61
7314454 1981
36
Residual vision in humans who have been monocularly deprived of pattern stimulation in early life. 61
7308343 1981
37
Visual functions following bilateral surgery of congenital cataracts in children. 61
458528 1979
38
Recovery from monocular stimulus deprivation amblyopia in the kitten. 61
353621 1978
39
Management of cataracts in infancy and childhood. 61
271384 1977
40
Persistent hyperplastic primary vitreous: roto-extraction and other surgical experience. 61
402128 1977
41
Modification of visual function by early visual experience. 61
825172 1976
42
[Stimulus deprivation amblyopia (author's transl)]. 61
966574 1976
43
Stimulus deprivation amblyopia. 61
4675094 1972
44
Receptive field function in stimulus deprivation amblyopia. 61
5089870 1971
45
Experimental amblyopia in monkeys. I. Behavioral studies of stimulus deprivation amblyopia. 61
4988775 1970
46
Clinical observations on stimulus-deprivation amblyopia (amblyopia ex anopsia). 61
5636023 1968
47
Clinical observations on stimulus-deprivation amblyopia (amblyopia ex anopsia). 61
5299903 1967

Variations for Disuse Amblyopia

Expression for Disuse Amblyopia

Search GEO for disease gene expression data for Disuse Amblyopia.

Pathways for Disuse Amblyopia

GO Terms for Disuse Amblyopia

Cellular components related to Disuse Amblyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic side of plasma membrane GO:0009898 9.26 CHMP4B CHMP4A
2 multivesicular body GO:0005771 9.16 CHMP4B CHMP4A
3 membrane coat GO:0030117 8.96 CHMP4B CHMP4A
4 ESCRT III complex GO:0000815 8.62 CHMP4B CHMP4A

Biological processes related to Disuse Amblyopia according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 mitotic metaphase plate congression GO:0007080 9.55 CHMP4B CHMP4A
2 multivesicular body assembly GO:0036258 9.54 CHMP4B CHMP4A
3 viral life cycle GO:0019058 9.52 CHMP4B CHMP4A
4 nucleus organization GO:0006997 9.51 CHMP4B CHMP4A
5 viral budding via host ESCRT complex GO:0039702 9.49 CHMP4B CHMP4A
6 vacuolar transport GO:0007034 9.48 CHMP4B CHMP4A
7 negative regulation of autophagosome assembly GO:1902902 9.46 CHMP4B CHMP4A
8 midbody abscission GO:0061952 9.43 CHMP4B CHMP4A
9 vesicle budding from membrane GO:0006900 9.4 CHMP4B CHMP4A
10 protein polymerization GO:0051258 9.37 CHMP4B CHMP4A
11 lens morphogenesis in camera-type eye GO:0002089 9.32 TDRD7 PITX3
12 lens fiber cell differentiation GO:0070306 9.26 TDRD7 PITX3
13 late endosome to vacuole transport via multivesicular body sorting pathway GO:0032511 9.16 CHMP4B CHMP4A
14 posttranslational protein targeting to endoplasmic reticulum membrane GO:0006620 8.96 CHMP4B CHMP4A
15 lens development in camera-type eye GO:0002088 8.8 PITX3 FOXE3 CRYGS

Molecular functions related to Disuse Amblyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of eye lens GO:0005212 8.62 CRYGS CRYAA

Sources for Disuse Amblyopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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