Aliases & Classifications for Disuse Amblyopia

MalaCards integrated aliases for Disuse Amblyopia:

Name: Disuse Amblyopia 12 15
Stimulus Deprivation Amblyopia 73
Deprivation Amblyopia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10378
ICD10 33 H53.01
ICD9CM 35 368.02
SNOMED-CT 68 193638002 21457000
UMLS 73 C0152189

Summaries for Disuse Amblyopia

MalaCards based summary : Disuse Amblyopia, also known as stimulus deprivation amblyopia, is related to anisometropia and septopreoptic holoprosencephaly. An important gene associated with Disuse Amblyopia is PLXNA2 (Plexin A2), and among its related pathways/superpathways are Pathways in cancer and Hedgehog Pathway. Affiliated tissues include eye, and related phenotypes are behavior/neurological and cellular

Related Diseases for Disuse Amblyopia

Diseases related to Disuse Amblyopia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 anisometropia 10.6 CHN1 DPT
2 septopreoptic holoprosencephaly 10.5 GLI2 SHH
3 midline interhemispheric variant of holoprosencephaly 10.5 GLI2 SHH
4 alobar holoprosencephaly 10.4 GLI2 SHH
5 marcus gunn phenomenon 10.3 CHN1 FOS
6 spastic paraplegia 25, autosomal recessive 10.3 FGF13 FGF2
7 clivus chordoma 10.2 FGF13 FGF2
8 pallister-hall syndrome 10.2 GLI2 SHH
9 cerebral hypoxia 10.2 FOS NOS1
10 amblyopia 10.1
11 diffuse glomerulonephritis 10.0 FGF13 FGF2
12 cataract 10.0
13 asthenopia 10.0 CADM1 SDCBP
14 lobar holoprosencephaly 9.8 GLI2 SHH
15 ametropic amblyopia 9.8 CADM1 CHN1 DPT SDCBP

Graphical network of the top 20 diseases related to Disuse Amblyopia:



Diseases related to Disuse Amblyopia

Symptoms & Phenotypes for Disuse Amblyopia

MGI Mouse Phenotypes related to Disuse Amblyopia:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.36 FGF2 FOS FOXA2 GLI2 GRM1 NOS1
2 cellular MP:0005384 10.31 NOS1 PLXNA2 SHH SLC2A1 ATP7B CADM1
3 growth/size/body region MP:0005378 10.26 ATP7B CADM1 CHN1 DPT FOS FOXA2
4 mortality/aging MP:0010768 10.25 FOXA2 GLI2 GRM1 NOS1 SHH SLC2A1
5 homeostasis/metabolism MP:0005376 10.2 GLI2 GRM1 NOS1 SHH SLC2A1 ATP7B
6 nervous system MP:0003631 10.2 ATP7B CADM1 CHN1 EPHA2 FGF13 FGF2
7 muscle MP:0005369 9.95 ATP7B CHN1 FGF2 GLI2 GRM1 NOS1
8 normal MP:0002873 9.86 CHN1 EPHA2 FOS FOXA2 GLI2 NOS1
9 neoplasm MP:0002006 9.85 FGF2 FOS FOXA2 GRM1 SHH EPHA2
10 reproductive system MP:0005389 9.85 ATP7B CADM1 CSAD FGF2 FOS FOXA2
11 skeleton MP:0005390 9.61 CHN1 EPHA2 FGF2 FOS FOXA2 GLI2
12 vision/eye MP:0005391 9.32 DPT EPHA2 FGF2 FOS FOXA2 GLI2

Drugs & Therapeutics for Disuse Amblyopia

Search Clinical Trials , NIH Clinical Center for Disuse Amblyopia

Genetic Tests for Disuse Amblyopia

Anatomical Context for Disuse Amblyopia

MalaCards organs/tissues related to Disuse Amblyopia:

41
Eye

Publications for Disuse Amblyopia

Articles related to Disuse Amblyopia:

# Title Authors Year
1
Deprivation amblyopia and congenital hereditary cataract. ( 24138041 )
2013
2
Spectral-domain optical coherence tomography analysis in deprivational amblyopia: a pilot study with unilateral pediatric cataract patients. ( 24146271 )
2013
3
The effect of video game training on the vision of adults with bilateral deprivation amblyopia. ( 23193607 )
2012
4
Protection against deprivation amblyopia depends on relative not absolute daily binocular exposure. ( 21680647 )
2011

Variations for Disuse Amblyopia

Expression for Disuse Amblyopia

Search GEO for disease gene expression data for Disuse Amblyopia.

Pathways for Disuse Amblyopia

GO Terms for Disuse Amblyopia

Cellular components related to Disuse Amblyopia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 8.92 NOS1 SDCBP SHH SLC2A1

Biological processes related to Disuse Amblyopia according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.73 FGF2 FOS FOXA2 GLI2 NOS1 SHH
2 ephrin receptor signaling pathway GO:0048013 9.61 CHN1 EPHA2 SDCBP
3 dopaminergic neuron differentiation GO:0071542 9.58 FOXA2 SHH
4 anatomical structure formation involved in morphogenesis GO:0048646 9.57 GLI2 SHH
5 hindbrain development GO:0030902 9.56 GLI2 SHH
6 spinal cord motor neuron differentiation GO:0021522 9.54 GLI2 SHH
7 cell fate specification GO:0001708 9.52 FOXA2 SHH
8 osteoblast development GO:0002076 9.51 GLI2 SHH
9 prostate gland development GO:0030850 9.49 GLI2 SHH
10 embryonic morphogenesis GO:0048598 9.48 FGF2 SHH
11 dorsal/ventral neural tube patterning GO:0021904 9.46 GLI2 SHH
12 limb bud formation GO:0060174 9.4 PLXNA2 SHH
13 positive regulation of T cell differentiation in thymus GO:0033089 9.37 GLI2 SHH
14 spinal cord dorsal/ventral patterning GO:0021513 9.32 GLI2 SHH
15 hindgut morphogenesis GO:0007442 9.16 GLI2 SHH
16 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 8.96 GLI2 SHH
17 ventral midline development GO:0007418 8.62 GLI2 SHH
18 positive regulation of transcription by RNA polymerase II GO:0045944 10.02 FGF2 FOS FOXA2 GLI2 NOS1 SHH

Sources for Disuse Amblyopia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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