MCID: DVR006
MIFTS: 38

Diversion Colitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Diversion Colitis

MalaCards integrated aliases for Diversion Colitis:

Name: Diversion Colitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060187
ICD10 33 K52
ICD9CM 35 558 558.9

Summaries for Diversion Colitis

Disease Ontology : 12 A colitis caused_by diversion of the fecal stream due to complication of ileostomy or colostomy.

MalaCards based summary : Diversion Colitis is related to colitis and inflammatory bowel disease. An important gene associated with Diversion Colitis is S1PR4 (Sphingosine-1-Phosphate Receptor 4), and among its related pathways/superpathways are Akt Signaling and PAK Pathway. Affiliated tissues include colon, spinal cord and appendix, and related phenotypes are cellular and digestive/alimentary

Wikipedia : 76 Diversion colitis is an inflammation of the colon which can occur as a complication of ileostomy or... more...

Related Diseases for Diversion Colitis

Diseases related to Diversion Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 colitis 31.0 IL1B IL4 MUC2
2 inflammatory bowel disease 29.2 ICAM1 IL1B IL4 MUC2
3 focal segmental glomerulosclerosis 1 10.1 ICAM1 IL1B
4 actinic prurigo 10.1 ICAM1 IL1B
5 microinvasive gastric cancer 10.1 CDH1 MUC2
6 limbal stem cell deficiency 10.1 ICAM1 IL1B
7 gastric cancer, hereditary diffuse 10.1 CDH1 IL1B
8 crohn's colitis 10.1 CDH1 IL1B
9 signet ring cell adenocarcinoma 10.1 CDH1 MUC2
10 tubular adenocarcinoma 10.1 CDH1 MUC2
11 autoimmune vasculitis 10.1 IL1B IL4
12 papillary adenocarcinoma 10.1 CDH1 MUC2
13 bile duct adenocarcinoma 10.1 CDH1 MUC2
14 opisthorchiasis 10.1 IL1B IL4
15 bronchiolo-alveolar adenocarcinoma 10.1 CDH1 MUC2
16 epstein-barr virus-associated gastric carcinoma 10.1 CDH1 MUC2
17 primary systemic mycosis 10.1 IL1B IL4
18 chronic conjunctivitis 10.1 ICAM1 IL4
19 eales disease 10.1 IL1B IL4
20 vernal keratoconjunctivitis 10.1 ICAM1 IL4
21 bardet-biedl syndrome 15 10.1 ICAM1 IL4
22 poliomyelitis 10.1 ICAM1 IL4
23 lichen disease 10.1 ICAM1 IL4
24 lymphadenitis 10.0 CCR7 ICAM1 IL1B
25 q fever 10.0 IL1B IL4
26 stomach disease 10.0 CDH1 IL1B MUC2
27 intestinal disease 10.0 CDH1 IL1B MUC2
28 aphthous stomatitis 10.0 IL1B IL4
29 gastrointestinal system disease 10.0 CDH1 IL1B MUC2
30 ulcerative colitis 10.0
31 keratoconjunctivitis sicca 10.0 IL1B IL4
32 otitis media 10.0 IL1B IL4 MUC2
33 pulmonary fibrosis, idiopathic 10.0 CCR7 CDH1 IL1B
34 allergic conjunctivitis 10.0 ICAM1 IL4
35 pleural disease 10.0 CXCL13 IL1B
36 extrinsic cardiomyopathy 10.0 ICAM1 IL1B IL4
37 autoimmune uveitis 10.0 ICAM1 IL1B IL4
38 parasitic protozoa infectious disease 10.0 ICAM1 IL1B IL4
39 autoimmune disease of central nervous system 10.0 ICAM1 IL1B IL4
40 allergic contact dermatitis 10.0 ICAM1 IL1B IL4
41 contact dermatitis 10.0 ICAM1 IL1B IL4
42 upper respiratory tract disease 10.0 ICAM1 IL1B IL4
43 trypanosomiasis 10.0 ICAM1 IL1B IL4
44 immune system disease 10.0 ICAM1 IL1B IL4
45 proteasome-associated autoinflammatory syndrome 1 10.0 ICAM1 IL1B IL4
46 nasal cavity disease 9.9 ICAM1 IL4
47 neurosyphilis 9.9 CXCL13 CXCR5
48 somatoform disorder 9.9 IL1B IL4
49 large intestine cancer 9.9 CDH1 EIF2AK3 IL1B MUC2
50 nose disease 9.8 ICAM1 IL4

Graphical network of the top 20 diseases related to Diversion Colitis:



Diseases related to Diversion Colitis

Symptoms & Phenotypes for Diversion Colitis

MGI Mouse Phenotypes related to Diversion Colitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 CCR7 CDH1 CXCL13 CXCR5 EIF2AK3 ICAM1
2 digestive/alimentary MP:0005381 9.8 CCR7 CDH1 EIF2AK3 ICAM1 IL4 MUC2
3 hematopoietic system MP:0005397 9.76 CCR7 CXCL13 CXCR5 ICAM1 IL1B IL4
4 endocrine/exocrine gland MP:0005379 9.73 CCR7 CDH1 EIF2AK3 ICAM1 IL4 MUC2
5 immune system MP:0005387 9.61 CCR7 CDH1 CXCL13 CXCR5 EIF2AK3 ICAM1
6 neoplasm MP:0002006 9.02 CDH1 EIF2AK3 ICAM1 IL1B MUC2

Drugs & Therapeutics for Diversion Colitis

Search Clinical Trials , NIH Clinical Center for Diversion Colitis

Genetic Tests for Diversion Colitis

Anatomical Context for Diversion Colitis

MalaCards organs/tissues related to Diversion Colitis:

41
Colon, Spinal Cord, Appendix, Tonsil

Publications for Diversion Colitis

Articles related to Diversion Colitis:

(show top 50) (show all 79)
# Title Authors Year
1
Diversion colitis and pouchitis: A mini-review. ( 29713128 )
2018
2
The Role of Autologous Fecal Microbiota Transplantation in Diversion Colitis: A Case Report. ( 30534963 )
2018
3
[RETRACTED ARTICLE]: EVALUATION OF ENEMAS CONTAINING SUCRALFATE IN TISSUE CONTENT OF MUC-2 PROTEIN IN EXPERIMENTAL MODEL OF DIVERSION COLITIS. ( 30540117 )
2018
4
Successful Long-term Treatment of Diversion Colitis with Topical Coconut Oil Application. ( 30353052 )
2018
5
The surgical treatment of acute and severe diversion colitis mimicking ulcerative colitis: a case report. ( 30073476 )
2018
6
EVALUATION OF ENEMAS CONTAINING SUCRALFATE IN TISSUE CONTENT OF MUC-2 PROTEIN IN EXPERIMENTAL MODEL OF DIVERSION COLITIS. ( 30133683 )
2018
7
Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice. ( 30059029 )
2018
8
Deviation of the Fecal Stream in Colonic Bowel Segments Results in Increased Numbers of Isolated Lymphoid Follicles in the Submucosal Compartment in a Novel Murine Model of Diversion Colitis. ( 28884123 )
2017
9
EVALUATION OF ENEMAS CONTAINING SUCRALFATE IN TISSUE CONTENT OF MUC-2 PROTEIN IN EXPERIMENTAL MODEL OF DIVERSION COLITIS. ( 29257850 )
2017
10
Diversion colitis 25A years later: the phenomenon of the disease. ( 28357500 )
2017
11
Anti-inflammatory effects of enemas containing an oily extract of curcumin in an experimental model of diversion colitis. ( 27237942 )
2016
12
Efficacy of Combined Mesalazine Plus Corticosteroid Enemas for Diversion Colitis after Subtotal Colectomy for Ulcerative Colitis. ( 27403119 )
2016
13
Successful autologous fecal transplantation for chronic diversion colitis. ( 25300242 )
2014
14
Relationship between the severity of diversion colitis and the composition of colonic bacteria: a prospective study. ( 24672659 )
2014
15
Pathophysiology, clinical presentation and management of diversion colitis: A review of current literature. ( 25150021 )
2014
16
Ascidian (chordate-tunicate) and mammalian heparin enemas attenuate experimental diversion colitis. ( 24287143 )
2014
17
Evaluation of the application of enemas containing sucralfate in tissue content of neutral and acid mucins in experimental model of diversion colitis. ( 25252200 )
2014
18
Relationship between diversion colitis and quality of life in rectal cancer. ( 23382634 )
2013
19
Confocal laser endomicroscopy for the diagnosis of diversion colitis. ( 23012020 )
2012
20
Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis. ( 22969190 )
2012
21
The importance of oxygen free radicals in the etiopathogenesis of diversion colitis in rats. ( 20877947 )
2010
22
Quantification by computerized morphometry of tissue levels of sulfomucins and sialomucins in diversion colitis in rats. ( 20498935 )
2010
23
Comparison of prophylactic and therapeutic use of short-chain fatty acid enemas in diversion colitis: a study in Wistar rats. ( 21340226 )
2010
24
An incidental enterocolic lymphocytic phlebitis pattern is seen commonly in the rectal stump of patients with diversion colitis superimposed on inflammatory bowel disease. ( 19147627 )
2009
25
Diversion colitis in a 19-year-old female with megacystis-microcolon-intestinal hypoperistalsis syndrome. ( 19582576 )
2009
26
How to treat diversion colitis?--Current state of medical knowledge, own research and experience. ( 19069697 )
2008
27
Antegrade irrigations of a surgically reconstructed Hartmann's pouch to treat intractable diversion colitis. ( 18344801 )
2008
28
Microcarcinoids associated with diversion colitis in a patient with Crohn's disease. ( 21172219 )
2008
29
Diversion colitis presenting with massive rectal distension and bilateral ureteric obstruction. ( 18443804 )
2008
30
Ischaemia: a pathogenetic clue in diversion colitis? ( 17824976 )
2007
31
Noninfectious colitides: collagenous colitis, lymphocytic colitis, diversion colitis, and chemically induced colitis. ( 20011361 )
2007
32
Intraluminal irrigation with fibers improves mucosal inflammation and atrophy in diversion colitis. ( 14962686 )
2004
33
Diversion colitis in sigmoid neovagina. ( 15206977 )
2004
34
Diversion colitis with a mucosal tear on endoscopic insufflation. ( 12912883 )
2003
35
Diversion colitis in children with colovaginoplasty. ( 11412227 )
2001
36
Diversion Colitis. ( 11469982 )
2001
37
Diversion colitis in children: an iatrogenic appendix vermiformis? ( 10632750 )
2000
38
Diversion colitis as a trigger for ulcerative colitis. ( 10712080 )
2000
39
Diversion colitis: a trigger for ulcerative colitis in the instream colon. ( 10733317 )
2000
40
Diversion colitis in patients with myelopathy: clinical, endoscopic, and histopathological findings. ( 10914356 )
2000
41
Diversion colitis: a trigger for ulcerative colitis in the in-stream colon? ( 9895391 )
1999
42
Diversion colitis--new light through old windows. ( 9934577 )
1999
43
Diversion colitis: new light through old windows. ( 10383719 )
1999
44
Diversion colitis: new light through old windows ( 10383813 )
1999
45
Diversion colitis: a cause of abdominal discomfort in spinal cord injury patients with colostomy. ( 9196478 )
1997
46
Mucosal inflammation in pediatric diversion colitis: a quantitative analysis. ( 9285377 )
1997
47
Nitrate-reducing bacteria in diversion colitis: a clue to inflammation? ( 9440640 )
1997
48
A severe case of diversion colitis with large ulcerations. ( 7661179 )
1995
49
The new colitides, Collagenous, lymphocytic, and diversion colitis. ( 8809245 )
1995
50
Aphthoid ulceration in diversion colitis. ( 7868095 )
1994

Variations for Diversion Colitis

Expression for Diversion Colitis

Search GEO for disease gene expression data for Diversion Colitis.

Pathways for Diversion Colitis

Pathways related to Diversion Colitis according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.14 CCR7 CXCL13 CXCR5 IL1B IL4
2
Show member pathways
12.7 CCR7 CDH1 CXCL13 CXCR5 IL1B IL4
3
Show member pathways
12.39 CXCL13 CXCR5 ICAM1 IL1B IL4
4
Show member pathways
12.09 ICAM1 IL1B IL4
5
Show member pathways
11.95 CCR7 CXCL13 ICAM1 IL1B
6 11.73 ICAM1 IL1B IL4
7
Show member pathways
11.72 CDH1 ICAM1 IL1B IL4
8
Show member pathways
11.71 EIF2AK3 ICAM1 IL1B IL4 NXT2
9
Show member pathways
11.7 CCR7 CXCL13 CXCR5
10 11.67 ICAM1 IL1B IL4
11 11.45 CXCR5 IL1B IL4
12 11.35 CXCL13 IL1B IL4
13 11.16 ICAM1 IL1B
14 11.13 ICAM1 IL1B
15 11.07 IL1B IL4
16 11.02 IL1B IL4
17 10.93 CXCL13 IL1B IL4
18 10.91 ICAM1 IL1B
19 10.82 ICAM1 IL1B IL4
20 10.74 CDH1 CXCL13 IL1B IL4
21 10.7 ICAM1 IL1B

GO Terms for Diversion Colitis

Biological processes related to Diversion Colitis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.71 CCR7 ICAM1 IL1B
2 response to lipopolysaccharide GO:0032496 9.61 CCR7 ICAM1 IL1B
3 cellular response to lipopolysaccharide GO:0071222 9.58 CXCL13 ICAM1 IL1B
4 positive regulation of nitric oxide biosynthetic process GO:0045429 9.56 ICAM1 IL1B
5 cellular response to organic substance GO:0071310 9.55 ICAM1 IL1B
6 chemotaxis GO:0006935 9.54 CCR7 CXCL13 CXCR5
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.52 ICAM1 IL4
8 B cell activation GO:0042113 9.51 CXCR5 IL4
9 calcium-mediated signaling GO:0019722 9.5 CCR7 CXCR5 EIF2AK3
10 positive regulation of vascular endothelial growth factor production GO:0010575 9.49 EIF2AK3 IL1B
11 leukocyte chemotaxis GO:0030595 9.48 CXCL13 CXCR5
12 positive regulation of neutrophil chemotaxis GO:0090023 9.46 CCR7 IL1B
13 cell chemotaxis GO:0060326 9.43 CCR7 CXCL13 CXCR5
14 immune response GO:0006955 9.43 CCR7 CXCL13 CXCR5 IL1B IL4 S1PR4
15 chemokine-mediated signaling pathway GO:0070098 9.33 CCR7 CXCL13 CXCR5
16 positive regulation of cytosolic calcium ion concentration GO:0007204 9.02 CCR7 CXCL13 CXCR5 IL1B S1PR4

Molecular functions related to Diversion Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.43 CXCL13 IL1B IL4
2 chemokine binding GO:0019956 9.16 CCR7 CXCR5
3 C-C chemokine binding GO:0019957 8.96 CCR7 CXCR5
4 C-C chemokine receptor activity GO:0016493 8.62 CCR7 CXCR5

Sources for Diversion Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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