MCID: DVR006
MIFTS: 31

Diversion Colitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Diversion Colitis

MalaCards integrated aliases for Diversion Colitis:

Name: Diversion Colitis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0060187
ICD9CM 34 558
ICD10 32 K52
UMLS 71 C0029512 C0267532

Summaries for Diversion Colitis

Disease Ontology : 12 A colitis caused by diversion of the fecal stream due to complication of ileostomy or colostomy.

MalaCards based summary : Diversion Colitis is related to colitis and ulcerative colitis. An important gene associated with Diversion Colitis is FFAR2 (Free Fatty Acid Receptor 2), and among its related pathways/superpathways are Peptide ligand-binding receptors and cAMP signaling pathway. The drug Cola has been mentioned in the context of this disorder. Affiliated tissues include colon, spinal cord and appendix, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 74 Diversion colitis is an inflammation of the colon which can occur as a complication of ileostomy or... more...

Related Diseases for Diversion Colitis

Diseases related to Diversion Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 colitis 10.7
2 ulcerative colitis 10.2
3 crohn's disease 10.1
4 inflammatory bowel disease 10.1
5 proctitis 10.0
6 diverticulitis 10.0
7 lymphocytic colitis 9.9
8 diarrhea 9.9
9 rectum cancer 9.9
10 collagenous colitis 9.8
11 crohn's colitis 9.8
12 fibrosis of extraocular muscles, congenital, 1 9.7
13 lipoid congenital adrenal hyperplasia 9.7
14 enterocolitis 9.7
15 megacystis-microcolon-intestinal hypoperistalsis syndrome 9.7
16 microcolon 9.7
17 androgen insensitivity syndrome 9.7
18 microscopic colitis 9.7
19 ileocolitis 9.7
20 intestinal pseudo-obstruction 9.7
21 blind loop syndrome 9.7
22 constipation 9.7
23 vaginal discharge 9.7
24 appendicitis 9.7
25 ileus 9.7
26 spinal cord injury 9.7
27 pouchitis 9.7
28 pellagra 9.4 SLC5A8 HCAR2 HCAR1

Graphical network of the top 20 diseases related to Diversion Colitis:



Diseases related to Diversion Colitis

Symptoms & Phenotypes for Diversion Colitis

GenomeRNAi Phenotypes related to Diversion Colitis according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-112 9.6 SLC16A1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-117 9.6 SLC16A1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.6 HCAR1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-129 9.6 SLC16A1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.6 HCAR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.6 FFAR3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-181 9.6 SLC16A1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.6 FFAR3
9 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.6 HCAR1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.6 FFAR3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.6 SLC16A1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.6 SLC16A1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.6 FFAR3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.6 SLC16A1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.6 HCAR1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-75 9.6 FFAR3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.6 HCAR1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-98 9.6 HCAR1 SLC16A1

MGI Mouse Phenotypes related to Diversion Colitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.35 ATG16L1 FFAR2 FFAR3 SLC16A1 SLC5A8
2 homeostasis/metabolism MP:0005376 9.23 ATG16L1 FFAR2 FFAR3 HCAR1 HCAR2 PYY

Drugs & Therapeutics for Diversion Colitis

Drugs for Diversion Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Cola

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Benefiber-Added, Reduced-Osmolarity WHO-ORS in the Treatment of Cholera in Adults Completed NCT00672308 Phase 2
2 Risk Factors of Cat Scratch Colon Developing. Completed NCT01574547

Search NIH Clinical Center for Diversion Colitis

Genetic Tests for Diversion Colitis

Anatomical Context for Diversion Colitis

MalaCards organs/tissues related to Diversion Colitis:

40
Colon, Spinal Cord, Appendix

Publications for Diversion Colitis

Articles related to Diversion Colitis:

(show top 50) (show all 156)
# Title Authors PMID Year
1
Reply to HEP-20-0140 Letter to the Editors: Could Butyrate Be Incorporated With Farnesoid X Receptor Agonist Cilofexor to Enhance Primary Sclerosing Cholangitis Treatment? 61
32279334 2020
2
[Clinicopathological features of diversion colitis similar to ulcerative colitis]. 61
30955272 2019
3
The Role of Autologous Fecal Microbiota Transplantation in Diversion Colitis: A Case Report. 61
30534963 2019
4
EFFICACY OF CURCUMA LONGA IN THE TREATMENT OF DIVERSION COLITIS IN RATS. 61
31826083 2019
5
Effects of anti-TNF-α in experimental diversion colitis. 61
31851212 2019
6
Successful Long-term Treatment of Diversion Colitis with Topical Coconut Oil Application. 61
30353052 2018
7
[RETRACTED ARTICLE]: EVALUATION OF ENEMAS CONTAINING SUCRALFATE IN TISSUE CONTENT OF MUC-2 PROTEIN IN EXPERIMENTAL MODEL OF DIVERSION COLITIS. 61
30540117 2018
8
Bladder Mucosal Graft Vaginoplasty: A Case Report. 61
29929017 2018
9
Differential diagnosis of inflammatory bowel disease: imitations and complications. 61
30102183 2018
10
The surgical treatment of acute and severe diversion colitis mimicking ulcerative colitis: a case report. 61
30073476 2018
11
EVALUATION OF ENEMAS CONTAINING SUCRALFATE IN TISSUE CONTENT OF MUC-2 PROTEIN IN EXPERIMENTAL MODEL OF DIVERSION COLITIS. 61
30133683 2018
12
Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice. 61
30059029 2018
13
Diversion colitis and pouchitis: A mini-review. 61
29713128 2018
14
Chronic Colitis in Biopsy Samples: Is It Inflammatory Bowel Disease or Something Else? 61
29103536 2017
15
Diversion colitis 25 years later: the phenomenon of the disease. 61
28357500 2017
16
EVALUATION OF ENEMAS CONTAINING SUCRALFATE IN TISSUE CONTENT OF MUC-2 PROTEIN IN EXPERIMENTAL MODEL OF DIVERSION COLITIS. 61
29257850 2017
17
Anti-inflammatory effects of enemas containing an oily extract of curcumin in an experimental model of diversion colitis. 61
27237942 2017
18
Deviation of the Fecal Stream in Colonic Bowel Segments Results in Increased Numbers of Isolated Lymphoid Follicles in the Submucosal Compartment in a Novel Murine Model of Diversion Colitis. 61
28884123 2017
19
Refractory diversion neovaginitis in a sigmoid-colon-derived neovagina: clinical and histopathological considerations. 61
28839860 2016
20
Morphological spectrum of neovaginitis in autologous sigmoid transplant patients. 61
26479413 2016
21
Diversion neovaginitis after sigmoid vaginoplasty: endoscopic and clinical characteristics. 61
26632208 2016
22
Efficacy of Combined Mesalazine Plus Corticosteroid Enemas for Diversion Colitis after Subtotal Colectomy for Ulcerative Colitis. 61
27403119 2016
23
Noninfectious colitides. 61
26034404 2015
24
Successful autologous fecal transplantation for chronic diversion colitis. 61
25300242 2015
25
Pathophysiology, clinical presentation and management of diversion colitis: a review of current literature. 61
25150021 2014
26
Evaluation of the application of enemas containing sucralfate in tissue content of neutral and acid mucins in experimental model of diversion colitis. 61
25252200 2014
27
Intestinal vaginoplasty revisited: a review of surgical techniques, complications, and sexual function. 61
24697986 2014
28
A modified total colonic exclusion for elderly patients with severe slow transit constipation. 61
24435473 2014
29
Relationship between the severity of diversion colitis and the composition of colonic bacteria: a prospective study. 61
24672659 2014
30
Ascidian (chordate-tunicate) and mammalian heparin enemas attenuate experimental diversion colitis. 61
24287143 2014
31
Enemas with N-acetylcysteine can reduce the level of oxidative damage in cells of the colonic mucosa diverted from the faecal stream. 61
23828143 2013
32
Clostridium difficile and inflammatory bowel disease: role in pathogenesis and implications in treatment. 61
24282348 2013
33
[A case of diversion colitis successfully treated with 5-aminosalicylic acid]. 61
23912004 2013
34
Filiform polyps and filiform polyp-like lesions are common in defunctioned or diverted colorectum resection specimens. 61
23665087 2013
35
Factors related to the development of cat scratch colon during colonoscopy. 61
23780841 2013
36
E-cadherin expression in colonic mucosa with and without fecal stream. 61
23273176 2013
37
Relationship between diversion colitis and quality of life in rectal cancer. 61
23382634 2013
38
Colitides. 61
23208963 2012
39
Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis. 61
22969190 2012
40
Confocal laser endomicroscopy for the diagnosis of diversion colitis. 61
23012020 2012
41
Rectosigmoid vaginoplasty: clinical experience and outcomes in 86 cases. 61
21995738 2011
42
5-aminosalicylic acid (5-ASA) can reduce levels of oxidative DNA damage in cells of colonic mucosa with and without fecal stream. 61
21042854 2011
43
The importance of oxygen free radicals in the etiopathogenesis of diversion colitis in rats. 61
20877947 2010
44
Quantification by computerized morphometry of tissue levels of sulfomucins and sialomucins in diversion colitis in rats. 61
20498935 2010
45
The effects of oxidative DNA damage and mutations in the p53 protein on cells of the colonic mucosa with and without the fecal stream: an experimental study in rats. 61
20201715 2010
46
Inflammatory alterations in excluded colon in rats: a comparison with chemically induced colitis. 61
20017653 2010
47
Comparison of prophylactic and therapeutic use of short-chain fatty acid enemas in diversion colitis: a study in Wistar rats. 61
21340226 2010
48
Diversion colitis in a 19-year-old female with megacystis-microcolon-intestinal hypoperistalsis syndrome. 61
19582576 2009
49
An incidental enterocolic lymphocytic phlebitis pattern is seen commonly in the rectal stump of patients with diversion colitis superimposed on inflammatory bowel disease. 61
19147627 2009
50
A case of fulminant diversion pan-colitis presenting 19 years after colonic diversion for neuronal intestinal dysplasia. 61
22207874 2009

Variations for Diversion Colitis

Expression for Diversion Colitis

Search GEO for disease gene expression data for Diversion Colitis.

Pathways for Diversion Colitis

GO Terms for Diversion Colitis

Cellular components related to Diversion Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.76 SLC5A8 SLC5A12 SLC16A1 S1PR4 HCAR2 HCAR1
2 plasma membrane GO:0005886 9.23 SLC5A8 SLC5A12 SLC16A1 S1PR4 HCAR2 HCAR1
3 apical plasma membrane GO:0016324 9.13 SLC5A8 SLC5A12 SLC16A1

Biological processes related to Diversion Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.85 S1PR4 PYY HCAR2 HCAR1 FFAR3 FFAR2
2 cellular response to fatty acid GO:0071398 9.48 FFAR3 FFAR2
3 positive regulation of chemokine production GO:0032722 9.46 FFAR3 FFAR2
4 monocarboxylic acid transport GO:0015718 9.43 SLC5A8 SLC16A1
5 positive regulation of cytokine production involved in immune response GO:0002720 9.4 FFAR3 FFAR2
6 mucosal immune response GO:0002385 9.32 FFAR3 FFAR2
7 organic acid transmembrane transport GO:1903825 9.26 SLC5A8 SLC5A12
8 regulation of peptide hormone secretion GO:0090276 9.16 FFAR3 FFAR2
9 positive regulation of acute inflammatory response to non-antigenic stimulus GO:0002879 8.96 FFAR3 FFAR2
10 lactate transmembrane transport GO:0035873 8.8 SLC5A8 SLC5A12 SLC16A1

Molecular functions related to Diversion Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.55 S1PR4 HCAR2 HCAR1 FFAR3 FFAR2
2 lipid binding GO:0008289 9.54 S1PR4 FFAR3 FFAR2
3 symporter activity GO:0015293 9.43 SLC5A8 SLC5A12 SLC16A1
4 monocarboxylic acid transmembrane transporter activity GO:0008028 9.32 SLC5A8 SLC16A1
5 organic acid:sodium symporter activity GO:0005343 8.96 SLC5A8 SLC5A12
6 lactate transmembrane transporter activity GO:0015129 8.8 SLC5A8 SLC5A12 SLC16A1

Sources for Diversion Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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