MCID: DVR006
MIFTS: 28

Diversion Colitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Diversion Colitis

MalaCards integrated aliases for Diversion Colitis:

Name: Diversion Colitis 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0060187
ICD9CM 34 558
ICD10 32 K52
UMLS 71 C0029512 C0267532

Summaries for Diversion Colitis

Disease Ontology : 12 A colitis caused by diversion of the fecal stream due to complication of ileostomy or colostomy.

MalaCards based summary : Diversion Colitis is related to colitis and ulcerative colitis. An important gene associated with Diversion Colitis is FFAR2 (Free Fatty Acid Receptor 2), and among its related pathways/superpathways are Peptide ligand-binding receptors and cAMP signaling pathway. Affiliated tissues include colon, spinal cord and appendix, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 74 Diversion colitis is an inflammation of the colon which can occur as a complication of ileostomy or... more...

Related Diseases for Diversion Colitis

Diseases related to Diversion Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 colitis 10.8
2 ulcerative colitis 10.4
3 crohn's disease 10.2
4 inflammatory bowel disease 10.2
5 proctitis 10.2
6 diverticulitis 10.2
7 lymphocytic colitis 10.1
8 rectum cancer 10.1
9 collagenous colitis 10.0
10 crohn's colitis 10.0
11 diarrhea 10.0
12 lipoid congenital adrenal hyperplasia 9.9
13 enterocolitis 9.9
14 megacystis-microcolon-intestinal hypoperistalsis syndrome 9.9
15 microcolon 9.9
16 androgen insensitivity syndrome 9.9
17 disease by infectious agent 9.9
18 microscopic colitis 9.9
19 ileocolitis 9.9
20 intestinal pseudo-obstruction 9.9
21 blind loop syndrome 9.9
22 constipation 9.9
23 vaginal discharge 9.9
24 appendicitis 9.9
25 ileus 9.9
26 spinal cord injury 9.9
27 pouchitis 9.9
28 gastrojejunal ulcer 9.6 PYY FFAR3 FFAR2
29 pellagra 9.5 SLC5A8 HCAR2 HCAR1

Graphical network of the top 20 diseases related to Diversion Colitis:



Diseases related to Diversion Colitis

Symptoms & Phenotypes for Diversion Colitis

GenomeRNAi Phenotypes related to Diversion Colitis according to GeneCards Suite gene sharing:

26 (show all 19)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-112 9.6 SLC16A1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-117 9.6 SLC16A1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-118 9.6 HCAR1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-129 9.6 SLC16A1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.6 HCAR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-148 9.6 FFAR3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-181 9.6 SLC16A1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.6 FFAR3
9 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.6 HCAR1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.6 FFAR3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.6 SLC16A1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.6 SLC16A1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.6 FFAR3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-72 9.6 SLC16A1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.6 HCAR1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-75 9.6 FFAR3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.6 HCAR1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-98 9.6 HCAR1 SLC16A1
19 Decreased viability ratio GR00368-A 9.35 FFAR2 FFAR3 HCAR1 HCAR2 PYY

Drugs & Therapeutics for Diversion Colitis

Search Clinical Trials , NIH Clinical Center for Diversion Colitis

Genetic Tests for Diversion Colitis

Anatomical Context for Diversion Colitis

MalaCards organs/tissues related to Diversion Colitis:

40
Colon, Spinal Cord, Appendix

Publications for Diversion Colitis

Articles related to Diversion Colitis:

(show top 50) (show all 159)
# Title Authors PMID Year
1
Evaluation of intestinal microbiota, short-chain fatty acids, and immunoglobulin a in diversion colitis. 61
33458259 2021
2
Spinal cord injuries and bowel stomas: timing and satisfaction with stoma formation and alterations in quality of life. 61
33536415 2021
3
The gut microbiota and colorectal surgery outcomes: facts or hype? A narrative review. 61
33579260 2021
4
[Progression of pathogenesis, diagnosis and treatment of diversion colitis]. 61
33212566 2020
5
The Impact of Rectal Stump Inflammation After Subtotal Colectomy on Pouch Outcomes in Ulcerative Colitis Patients. 61
32901798 2020
6
[Clinicopathological features of diversion colitis similar to ulcerative colitis]. 61
30955272 2019
7
The Role of Autologous Fecal Microbiota Transplantation in Diversion Colitis: A Case Report. 61
30534963 2019
8
EFFICACY OF CURCUMA LONGA IN THE TREATMENT OF DIVERSION COLITIS IN RATS. 61
31826083 2019
9
Effects of anti-TNF-α in experimental diversion colitis. 61
31851212 2019
10
Successful Long-term Treatment of Diversion Colitis with Topical Coconut Oil Application. 61
30353052 2018
11
[RETRACTED ARTICLE]: EVALUATION OF ENEMAS CONTAINING SUCRALFATE IN TISSUE CONTENT OF MUC-2 PROTEIN IN EXPERIMENTAL MODEL OF DIVERSION COLITIS. 61
30540117 2018
12
Bladder Mucosal Graft Vaginoplasty: A Case Report. 61
29929017 2018
13
Differential diagnosis of inflammatory bowel disease: imitations and complications. 61
30102183 2018
14
The surgical treatment of acute and severe diversion colitis mimicking ulcerative colitis: a case report. 61
30073476 2018
15
EVALUATION OF ENEMAS CONTAINING SUCRALFATE IN TISSUE CONTENT OF MUC-2 PROTEIN IN EXPERIMENTAL MODEL OF DIVERSION COLITIS. 61
30133683 2018
16
Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice. 61
30059029 2018
17
Diversion colitis and pouchitis: A mini-review. 61
29713128 2018
18
Chronic Colitis in Biopsy Samples: Is It Inflammatory Bowel Disease or Something Else? 61
29103536 2017
19
Diversion colitis 25 years later: the phenomenon of the disease. 61
28357500 2017
20
EVALUATION OF ENEMAS CONTAINING SUCRALFATE IN TISSUE CONTENT OF MUC-2 PROTEIN IN EXPERIMENTAL MODEL OF DIVERSION COLITIS. 61
29257850 2017
21
Anti-inflammatory effects of enemas containing an oily extract of curcumin in an experimental model of diversion colitis. 61
27237942 2017
22
Deviation of the Fecal Stream in Colonic Bowel Segments Results in Increased Numbers of Isolated Lymphoid Follicles in the Submucosal Compartment in a Novel Murine Model of Diversion Colitis. 61
28884123 2017
23
Refractory diversion neovaginitis in a sigmoid-colon-derived neovagina: clinical and histopathological considerations. 61
28839860 2016
24
Morphological spectrum of neovaginitis in autologous sigmoid transplant patients. 61
26479413 2016
25
Diversion neovaginitis after sigmoid vaginoplasty: endoscopic and clinical characteristics. 61
26632208 2016
26
Efficacy of Combined Mesalazine Plus Corticosteroid Enemas for Diversion Colitis after Subtotal Colectomy for Ulcerative Colitis. 61
27403119 2016
27
Noninfectious colitides. 61
26034404 2015
28
Successful autologous fecal transplantation for chronic diversion colitis. 61
25300242 2015
29
Pathophysiology, clinical presentation and management of diversion colitis: a review of current literature. 61
25150021 2014
30
Evaluation of the application of enemas containing sucralfate in tissue content of neutral and acid mucins in experimental model of diversion colitis. 61
25252200 2014
31
Intestinal vaginoplasty revisited: a review of surgical techniques, complications, and sexual function. 61
24697986 2014
32
A modified total colonic exclusion for elderly patients with severe slow transit constipation. 61
24435473 2014
33
Relationship between the severity of diversion colitis and the composition of colonic bacteria: a prospective study. 61
24672659 2014
34
Ascidian (chordate-tunicate) and mammalian heparin enemas attenuate experimental diversion colitis. 61
24287143 2014
35
Enemas with N-acetylcysteine can reduce the level of oxidative damage in cells of the colonic mucosa diverted from the faecal stream. 61
23828143 2013
36
Clostridium difficile and inflammatory bowel disease: role in pathogenesis and implications in treatment. 61
24282348 2013
37
[A case of diversion colitis successfully treated with 5-aminosalicylic acid]. 61
23912004 2013
38
Filiform polyps and filiform polyp-like lesions are common in defunctioned or diverted colorectum resection specimens. 61
23665087 2013
39
Factors related to the development of cat scratch colon during colonoscopy. 61
23780841 2013
40
E-cadherin expression in colonic mucosa with and without fecal stream. 61
23273176 2013
41
Relationship between diversion colitis and quality of life in rectal cancer. 61
23382634 2013
42
Colitides. 61
23208963 2012
43
Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis. 61
22969190 2012
44
Confocal laser endomicroscopy for the diagnosis of diversion colitis. 61
23012020 2012
45
Rectosigmoid vaginoplasty: clinical experience and outcomes in 86 cases. 61
21995738 2011
46
5-aminosalicylic acid (5-ASA) can reduce levels of oxidative DNA damage in cells of colonic mucosa with and without fecal stream. 61
21042854 2011
47
The importance of oxygen free radicals in the etiopathogenesis of diversion colitis in rats. 61
20877947 2010
48
Quantification by computerized morphometry of tissue levels of sulfomucins and sialomucins in diversion colitis in rats. 61
20498935 2010
49
The effects of oxidative DNA damage and mutations in the p53 protein on cells of the colonic mucosa with and without the fecal stream: an experimental study in rats. 61
20201715 2010
50
Inflammatory alterations in excluded colon in rats: a comparison with chemically induced colitis. 61
20017653 2010

Variations for Diversion Colitis

Expression for Diversion Colitis

Search GEO for disease gene expression data for Diversion Colitis.

Pathways for Diversion Colitis

GO Terms for Diversion Colitis

Cellular components related to Diversion Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.56 SLC5A8 SLC5A12 SLC16A1 S1PR4 HCAR2 HCAR1
2 apical plasma membrane GO:0016324 9.33 SLC5A8 SLC5A12 SLC16A1
3 plasma membrane GO:0005886 9.23 SLC5A8 SLC5A12 SLC16A1 S1PR4 HCAR2 HCAR1

Biological processes related to Diversion Colitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.89 S1PR4 HCAR2 HCAR1 FFAR3 FFAR2
2 G protein-coupled receptor signaling pathway GO:0007186 9.73 S1PR4 PYY HCAR2 HCAR1 FFAR3 FFAR2
3 positive regulation of chemokine production GO:0032722 9.48 FFAR3 FFAR2
4 cellular response to fatty acid GO:0071398 9.46 FFAR3 FFAR2
5 monocarboxylic acid transport GO:0015718 9.43 SLC5A8 SLC16A1
6 positive regulation of cytokine production involved in immune response GO:0002720 9.4 FFAR3 FFAR2
7 organic acid transmembrane transport GO:1903825 9.37 SLC5A8 SLC5A12
8 mucosal immune response GO:0002385 9.32 FFAR3 FFAR2
9 regulation of peptide hormone secretion GO:0090276 9.16 FFAR3 FFAR2
10 positive regulation of acute inflammatory response to non-antigenic stimulus GO:0002879 8.96 FFAR3 FFAR2
11 lactate transmembrane transport GO:0035873 8.8 SLC5A8 SLC5A12 SLC16A1

Molecular functions related to Diversion Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid binding GO:0008289 9.58 S1PR4 FFAR3 FFAR2
2 G protein-coupled receptor activity GO:0004930 9.55 S1PR4 HCAR2 HCAR1 FFAR3 FFAR2
3 transmembrane transporter activity GO:0022857 9.54 SLC5A8 SLC5A12 SLC16A1
4 symporter activity GO:0015293 9.43 SLC5A8 SLC5A12 SLC16A1
5 monocarboxylic acid transmembrane transporter activity GO:0008028 9.32 SLC5A8 SLC16A1
6 organic acid:sodium symporter activity GO:0005343 8.96 SLC5A8 SLC5A12
7 lactate transmembrane transporter activity GO:0015129 8.8 SLC5A8 SLC5A12 SLC16A1

Sources for Diversion Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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