Diverticulitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: DVR002 MIFTS: 43	Diverticulitis Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Diverticulitis

MalaCards integrated aliases for Diverticulitis:

Name: Diverticulitis ¹² ⁷⁴ ⁵⁴ ⁴³ ¹⁵ ¹⁷ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:7475

MeSH ⁴³ D004238

NCIt ⁴⁹ C26752

SNOMED-CT ⁶⁷ 18126004 307496006

EFO ¹⁷ EFO_1001460

UMLS ⁷¹ C0012813

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Summaries for Diverticulitis

Disease Ontology : ¹² An intestinal disease characterized by the formation and inflammation of diverticula within the bowel wall.

MalaCards based summary : Diverticulitis is related to diverticulitis of colon and appendicitis. An important gene associated with Diverticulitis is FAM155A (Family With Sequence Similarity 155 Member A), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Proteoglycans in cancer. The drugs Fentanyl and Ketorolac have been mentioned in the context of this disorder. Affiliated tissues include colon, appendix and kidney.

Wikipedia : ⁷⁴ Diverticulitis, specifically colonic diverticulitis, is a gastrointestinal disease characterized by... more...

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Related Diseases for Diverticulitis

Diseases related to Diverticulitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 477)

#	Related Disease	Score	Top Affiliating Genes
1	diverticulitis of colon	33.7	PHGR1 LAMB4 FAM155A CRP ACADS
2	appendicitis	31.8	TNF S100A9 MMP9 CRP
3	acute cystitis	31.0	TNF CRP CCR6
4	intestinal obstruction	31.0	TNF CRP ATP12A APOLD1
5	ulcerative colitis	30.9	TNFSF15 TNF CRP CCR6
6	crohn's disease	30.9	TNFSF15 TNF S100A9 CRP CCR6
7	intestinal perforation	30.8	TNF CRP ATP12A
8	intussusception	30.8	FGF2 CRP APOLD1
9	constipation	30.7	TNF CRP ATP12A APOLD1
10	pyoderma gangrenosum	30.7	TNF MMP9 CCR6
11	ischemic colitis	30.6	MMP9 CRP CCR6
12	peptic ulcer disease	30.5	TNF MUC5AC ATP12A
13	cellulitis	30.5	TNF CRP CCR6
14	anal fistula	30.4	TNF MMP9 APOLD1
15	pyoderma	30.4	TNF MMP9 CRP CCR6
16	bacterial meningitis	30.4	TNF MMP9 CRP
17	volvulus of midgut	30.4	CRP ATP12A APOLD1
18	peptic ulcer perforation	30.3	CRP ATP12A
19	gastroenteritis	30.3	TNF MMP9 CRP
20	intestinal disease	30.3	TNF SDC1 CRP CCR6
21	sarcoidosis 1	30.3	TNF S100A9 CRP CCR6
22	pustulosis of palm and sole	30.2	TNF CRP CCR6
23	leprosy 3	30.2	TNFSF15 TNF CCR6
24	pneumatosis cystoides intestinalis	30.2	CRP ATP12A
25	igg4-related disease	30.2	SDC1 CRP CCR6
26	urinary tract obstruction	30.1	TNF CRP CCR6
27	hyper ige syndrome	30.1	TNF MMP9 CCR6
28	vasculitis	30.0	TNF SERPINA1 S100A9 CRP
29	marginal zone b-cell lymphoma	30.0	SDC1 CCR6 ATP12A
30	colorectal adenoma	30.0	TNF MMP9 CRP
31	bronchiectasis	29.9	TNF SERPINA1 CRP
32	fibromyalgia	29.9	TNF SERPINA1 CRP
33	inflammatory bowel disease	29.8	TNFSF15 TNFRSF18 TNF S100A9 MUC5AC MMP9
34	toxic megacolon	29.8	TNF CRP CCR6 ATP12A
35	peripheral nervous system disease	29.8	TNF FGF2 CRP COLQ CCR6
36	granulomatosis with polyangiitis	29.7	TNF SERPINA1 CRP CCR6
37	autoimmune disease	29.7	TNFRSF18 TNF MMP9 CRP CCR6
38	proctitis	29.7	TNF FGF2 CRP CCR6 APOLD1
39	skin disease	29.7	TNF S100A9 FGF2 CRP CCR6
40	myeloma, multiple	29.6	TNF SDC1 MMP9 FGF2 CRP CCR6
41	respiratory failure	29.5	TNF SERPINA1 SDC1 MUC5AC CRP CCR6
42	pulmonary disease, chronic obstructive	29.4	TNF SERPINA1 MUC5AC MMP9 CRP CCR6
43	juvenile rheumatoid arthritis	29.3	TNF S100A9 CRP
44	meckel's diverticulitis	12.5
45	small intestine diverticulitis	12.4
46	peritonitis	11.8
47	colonic disease	11.6
48	autoimmune inner ear disease	10.6	TNF MMP9
49	ileus	10.6
50	drug reaction with eosinophilia and systemic symptoms	10.6	TNF CRP

Graphical network of the top 20 diseases related to Diverticulitis:

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Symptoms & Phenotypes for Diverticulitis

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Drugs & Therapeutics for Diverticulitis

Drugs for Diverticulitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 122)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 4

437-38-7

3345

Ketorolac

Approved

Phase 4

66635-83-4, 74103-06-3

3826

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1

3821

Methadone

Approved

Phase 4

76-99-3

4095

Hydrocodone

Approved, Illicit, Investigational

Phase 4

125-29-1

5284569

Tramadol

Approved, Investigational

Phase 4

27203-92-5

33741

Hydromorphone

Approved, Illicit

Phase 4

466-99-9

5284570

Gabapentin

Approved, Investigational

Phase 4

60142-96-3

3446

Orphenadrine

Approved

Phase 4

83-98-7

4601

Guaifenesin

Approved, Investigational, Vet_approved

Phase 4

93-14-1

3516

Acetaminophen

Approved

Phase 4

103-90-2

1983

Ibuprofen

Approved

Phase 4

15687-27-1

3672

Rifaximin

Approved, Investigational

Phase 4

80621-81-4

6436173 46783403

Clavulanate

Approved, Vet_approved

Phase 4

58001-44-8

5280980

Amoxicillin

Approved, Vet_approved

Phase 4

26787-78-0

33613

Ceftriaxone

Approved

Phase 4

73384-59-5

5361919 5479530

Tigecycline

Approved

Phase 4

220620-09-7

5282044

Bupivacaine

Approved, Investigational

Phase 4

2180-92-9, 38396-39-3

2474

Epinephrine

Approved, Vet_approved

Phase 4

51-43-4

5816

Racepinephrine

Approved

Phase 4

329-65-7

838

Analgesics, Non-Narcotic

Phase 4

Antirheumatic Agents

Phase 4

Anti-Inflammatory Agents

Phase 4

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

Respiratory System Agents

Phase 4

Ketorolac Tromethamine

Phase 4

Acetaminophen, hydrocodone drug combination

Phase 4

Excitatory Amino Acid Antagonists

Phase 4

Antitussive Agents

Phase 4

Cholinergic Agents

Phase 4

Parasympatholytics

Phase 4

Anesthetics, Dissociative

Phase 4

Antiparkinson Agents

Phase 4

Anti-Anxiety Agents

Phase 4

Anesthetics, General

Phase 4

Psychotropic Drugs

Phase 4

Muscarinic Antagonists

Phase 4

Anesthetics, Intravenous

Phase 4

Cholinergic Antagonists

Phase 4

Chlorpheniramine, phenylpropanolamine drug combination

Phase 4

Anticonvulsants

Phase 4

Analgesics

Phase 4

Antipyretics

Phase 4

Cyclooxygenase Inhibitors

Phase 4

Cola

Phase 4

Gastrointestinal Agents

Phase 4

beta-Lactamase Inhibitors

Phase 4

Anesthetics

Phase 4

Anesthetics, Local

Phase 4

Narcotics

Phase 4

Interventional clinical trials:

(show top 50) (show all 151)

#	Name	Status	NCT ID	Phase	Drugs
1	A Prospective, Multicenter, Open-Label, Randomized Clinical Study to Evaluate the Duration of Treatment With Ertapenem in Acute Attacks of Sigmoid Diverticulitis	Unknown status	NCT00097734	Phase 4	ertapenem
2	DIABOLO Trial: A Multicenter Randomized Clinical Trial Investigating the Cost-effectiveness of Treatment Strategies With or Without Antibiotics for Uncomplicated Acute Diverticulitis.	Unknown status	NCT01111253	Phase 4	Amoxicillin-clavulanate
3	Preoperative Assessment of Colon Tumor: A Prospective, Blinded Study.	Unknown status	NCT00114829	Phase 4
4	Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery as Part of an Enhanced Recovery After Surgery Protocol: A Randomized Prospective Single- Center Trial.	Unknown status	NCT02958566	Phase 4	Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
5	Randomized Trial Comparing Two Treatment Strategies for Acute Diverticulitis. Hospitalization or Ambulatory Antibiotic Treatment	Completed	NCT01081054	Phase 4
6	Prospective Randomized Clinical Trial Assessing the Efficacy of a Short Course of Intravenous Amoxicillin Plus Clavulanic Acid Followed by Oral Antibiotic in Patients With Uncomplicated Acute Diverticulitis	Completed	NCT00917592	Phase 4	amoxicillin plus clavulanic acid;amoxicillin plus clavulanic acid
7	Multicentre Controlled, Randomized Clinical Trial to Compare the Efficacy and Safety of Ambulatory Treatment of Mild Acute Diverticulitis Without Antibiotics With the Standard Treatment With Antibiotics	Completed	NCT02785549	Phase 4	Ibuprofen;Acetaminophen;Amoxicillin/clavulanic acid
8	Impact of Six Patient Information Leaflets (PIL) on Doctor Patient Communication and Adherence in Emergency Ward	Completed	NCT02246361	Phase 4
9	Laparoscopic Versus Open Sigmoid Colectomy for Diverticular Disease: A Prospective Randomized Single-Blind Trial	Completed	NCT00453830	Phase 4
10	A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection	Completed	NCT00195351	Phase 4	tigecycline;ceftriaxone sodium + metronidazole
11	Evaluation of Immunohistological Pattern in Patients With Uncomplicated Symptomatic Diverticular Disease and Correlation Between Intraluminal Bacterial Flora and Phlogosis	Completed	NCT02068482	Phase 4	Rifaximin
12	Compression Anastomosis: Initial Clinical Experience With the ColonRingTM	Completed	NCT01056913	Phase 4
13	A Multicenter, Open-Label, Randomized Comparative Study of Tigecycline vs Ceftriaxone Sodium Plus Metronidazole for the Treatment of Hospitalized Subjects With Complicated Intra-abdominal Infection	Completed	NCT00230971	Phase 4	tigecycline;ceftriaxone plus metronidazole
14	The Effect of Exparel on Post Operative Pain and Narcotic Use After Colon Surgery	Completed	NCT02052557	Phase 4	Bupivacaine;Bupivacaine liposome suspension
15	Phase 4 Study of Primary Use of the Vacuum Assisted Laparostomy in Treatment of Severe Peritonitis	Completed	NCT01531543	Phase 4
16	Laparoscopic Peritoneal Lavage or Resection for Generalised Peritonitis for Perforated Diverticulitis: a Nationwide Multicenter Randomised Trial	Unknown status	NCT01317485	Phase 3
17	Phase 3 Study of Lactobacillus Reuterii in Patients With Symptomatic Non-complicated Diverticular Disease	Unknown status	NCT01168154	Phase 3
18	Hartmann vs Resection With Anastomosis and Diverting Stoma for Peritonitis Caused by Perforated Left-sided Colon Diverticulitis: a Multicenter Prospective Randomized Study.	Completed	NCT01239927	Phase 2, Phase 3
19	A Phase III, Randomised, Double-Blind, Dose-Response, Stratified, Placebo-Controlled Study Evaluating the Safety and Efficacy of SPD476 Versus Placebo Over 104 Weeks in the Prevention of Recurrence of Diverticulitis.	Completed	NCT00545740	Phase 3	SPD476 (1.2g);SPD476 (2.4 g);SPD476 (4.8 g);Placebo
20	A Phase III, Randomised, Double-Blind, Dose-Response, Stratified, Placebo-Controlled Study Evaluating the Safety and Efficacy of SPD476 Versus Placebo Over 104 Weeks in the Prevention of Recurrence of Diverticulitis.	Completed	NCT00545103	Phase 3	SPD476, MMX™ mesalazine, 1.2g extended release tablet;SPD476, MMX™ mesalazine, 1.2g extended release tablet;SPD476, MMX™ mesalazine, 1.2g extended release tablet;Placebo
21	Evaluation of Efficacy of Mesalamine in the Long-term Prevention of Diverticulitis Flares	Completed	NCT01120340	Phase 3	mesalamine
22	Assessment of the Probiotic Symprove as a Dietary Supplement in Patients With Symptomatic Diverticular Disease	Completed	NCT02115867	Phase 3
23	A Randomized Prospective Double Blind Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy: Standard Care Versus Either Colloid and Crystalloid	Completed	NCT00467922	Phase 3	Hextend;Lactated Ringers
24	Prospective Randomized Study Comparing the Results of Digital Rectal Examination in the Supine and Lateral Decubitus	Completed	NCT01727388	Phase 3
25	Hartmann's Versus Primary Anastomosis in Left-sided Colon Perforation - A Prospective Randomized Multicenter Trial	Completed	NCT01233713	Phase 2, Phase 3
26	Rifaximin Delayed Release (400 mg Tablet) for the Prevention of Recurrent Acute Diverticulitis and Diverticular Complications. A Phase II, Multicenter, Double-blind, Placebo-controlled, Randomized Clinical Trial	Active, not recruiting	NCT03469050	Phase 2, Phase 3	Rifaximin delayed released 400mg Tablet
27	Double-blind, Randomized, Placebo-controlled, Parallel Group, Multi-centre Phase III Clinical Study on the Efficacy and Tolerability of Mesalazine Granules vs. Placebo for the Prevention of Recurrence of Diverticulitis	Terminated	NCT00695643	Phase 3	Mesalazine;Placebo
28	Double-blind, Dose-response, Randomised, Placebo-controlled, Parallel Group, Multi-centre Phase III Clinical Study on the Efficacy and Tolerability of Mesalazine Granules vs. Placebo for the Prevention of Recurrence of Diverticulitis	Terminated	NCT01038739	Phase 3	Mesalazine;Mesalazine;Placebo
29	The Analgesic Efficacy of Perioperative Δ9-THC (Namisol®) in Patients Undergoing Major Abdominal Surgery: A Randomized, Double Blinded, Placebo-controlled, Parallel Design	Unknown status	NCT01790555	Phase 2	Namisol;Diazepam/placebo
30	A Randomised, Double-blind, Double-dummy, Multi-centre, Comparative Parallel-group Study to Evaluate the Efficacy of Oral Rifamycin SV-MMX® 400 mg b.i.d. vs. Rifamycin SV-MMX® 600 mg t.i.d. vs. Placebo in the Treatment of Acute Uncomplicated Diverticulitis	Completed	NCT01847664	Phase 2	Rifamycin SV-MMX® 400 mg b.i.d.;Rifamycin SV-MMX® 600 mg t.i.d.;Rifamycin SV-MMX® Placebo
31	A Randomized, Double-blind, Placebo-controlled Study to Assess the Safety and Efficacy of a 12 Week Treatment of Acute Diverticulitis With Asacol® 2.4 g/Day (400 mg Mesalamine Tablet), Followed by a 9 Month Treatment-free Observation Period	Completed	NCT00554099	Phase 2	Mesalamine;Probiotic;Placebo;Antibiotic for Diverticulitis
32	End-to-End Compression Anastomosis for Left-sided Colectomy Endo-CAR Study	Completed	NCT00497263	Phase 2
33	Restoration of Bowel Function After Laparoscopic Colorectal Surgery: Effect of Intravenous Lidocaine	Completed	NCT01155440	Phase 2	Lidocaine
34	Spinal Analgesia for Colonic Resection Using an Enhanced Recovery After Surgery (ERAS) Program	Completed	NCT01477190	Phase 1, Phase 2	Spinal analgesia;Patient Control Analgesia (PCA) Morphine
35	Polyp Detection With The Peerscope System™: A Randomized Tandem Colonoscopy Study	Completed	NCT01549535	Phase 2
36	MANAGEMENT OF THE PATIENT WITH ACUTE ABDOMEN SUBMITTED TO URGENT ABDOMINAL SURGERY: a Pilot Randomized Multicentre Study	Completed	NCT01911702	Phase 2
37	Effectiveness of Interleukin-6 Receptor Inhibitors in the Management of Patients With Severe SARS-CoV-2 Pneumonia: An Open-Label, Multicenter Sequential and Cluster Randomized Trial	Recruiting	NCT04322773	Phase 2	RoActemra iv;RoActemra sc;Kevzara sc
38	Use of Autologous Adult Adipose-Derived Stem/Stromal Cells in Inflammatory Bowel Disease	Recruiting	NCT02952131	Phase 1, Phase 2
39	Phase II Trial on the Efficacy and Safety of Sclerotherapy Using 3% Polidocanol Foam to Treat Second-degree Hemorrhoidal Disease	Recruiting	NCT03791775	Phase 2	Polidocanol foam (Atossisclerol® 3%)
40	A Pilot Study of Immune Checkpoint Inhibition (Durvalumab With or Without Tremelimumab) in Combination With Radiation Therapy in Patients With Unresectable Pancreatic Cancer	Active, not recruiting	NCT02311361	Phase 1, Phase 2
41	BARICIVID-19 STUDY: MultiCentre, Randomised, Phase IIa Clinical Trial Evaluating Efficacy and Tolerability of Baricitinib as add-on Treatment of In-patients With COVID-19 Compared to Standard Therapy	Not yet recruiting	NCT04393051	Phase 2	Baricitinib Oral Tablet
42	A Randomized, Double-Blind, Placebo-Controlled Study Evaluating Asimadoline on the Duration of POI in Subjects Undergoing Laparoscopic/Hand-Assisted Lap Segmental Colonic Resection Secondary to Colon Cancer, Polypectomy or Diverticulitis	Terminated	NCT00443040	Phase 2	Asimadoline;Placebo
43	A Phase II Study of Pevonedistat (MLN4924, TAK924) and Azacitidine as Maintenance Therapy After Allogeneic Stem Cell Transplantation for Non-Remission Acute Myelogenous Leukemia	Terminated	NCT03709576	Phase 2	Pevonedistat;Azacitidine
44	Open Label Clinical Study to Demonstrate the Utility of Intra-operative Perfusion Assessment Using NIR Fluorescence Angiography With the PINPOINT® Endoscopic Fluorescence Imaging System and to Assess the Impact of PINPOINT on the Surgical Decision Making Process and on Surgical Outcomes in Laparoscopic Left Anterior Resection Procedures	Completed	NCT01560377	Phase 1
45	Phase I Study of the Humanized Mik-Beta-1 Monoclonal Antibody Directed Toward IL-2/IL-15R Beta (CD122) That Blocks IL-15 Action In Patients With Refractory Celiac Disease	Completed	NCT01893775	Phase 1
46	An Open-Label Trial of Tocilizumab in Schizophrenia	Completed	NCT01696929	Phase 1	Tocilizumab
47	Predictive Value of C-Reactive Protein in Acute Diverticulitis	Unknown status	NCT01825967
48	Procalcitonin REveals Good Recovery After Acute Diverticulitis: the PREGRAD Study	Unknown status	NCT02817854
49	Natural History of Sigmoid Diverticulitis: The Geneva Cohort Study	Unknown status	NCT01015378
50	Multicenter Randomized Study Comparing Morbidity and Quality of Life Associated in the Treatment by Surgical Resection and the Conservative Treatment, After Favorable Evolution of Purulent Peritonitis That Originates From Diverticulitis Treated by Mini-invasive Surgery.	Unknown status	NCT01837342

Search NIH Clinical Center for Diverticulitis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Scopolamine

Scopolamine Hydrobromide

Cochrane evidence based reviews: diverticulitis

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Genetic Tests for Diverticulitis

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Anatomical Context for Diverticulitis

MalaCards organs/tissues related to Diverticulitis:

⁴⁰

Colon, Appendix, Kidney, Liver, Lung, Small Intestine, Heart

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Publications for Diverticulitis

Articles related to Diverticulitis:

(show top 50) (show all 6408)

#	Title	Authors	PMID	Year
1	Increased distribution of collagen type III and reduced expression of matrix metalloproteinase 1 in patients with diverticular disease. ⁵⁴ ⁶¹	Stumpf M...Schumpelick V	11686522	2001
2	[Sensitivity and specificity of alpha-1-antitrypsin and acid alpha-1-glycoprotein in colorectal carcinoma]. ⁶¹ ⁵⁴	Putzki H...Hafner O	1725848	1991
3	Incidence Trends, Comorbidities, and Outcomes of Pyogenic Liver Abscess Among Children: A Nationwide Population-based Analysis. ⁶¹	Thavamani A...Radhakrishnan K	32142002	2020
4	MDCT in the Setting of Suspected Colonic Diverticulitis: Prevalence and Diagnostic Yield for Diverticulitis and Alternative Diagnoses. ⁶¹	Weinrich JM...Henes FO	32319796	2020
5	Laparoscopic Sigmoid Resection for Diverticulitis. ⁶¹	Bello BL	32496334	2020
6	Immune checkpoint inhibitors-induced acute diverticulitis. ⁶¹	Tursi A	32472816	2020
7	Family History Is Associated With Recurrent Diverticulitis After an Episode of Diverticulitis Managed Nonoperatively. ⁶¹	Almalki T...Boutros M	32217858	2020
8	Acute diverticulitis: Key features for guiding clinical management. ⁶¹	Sugi MD...Choi HH	32422553	2020
9	Observational versus antibiotic treatment for uncomplicated diverticulitis: an individual-patient data meta-analysis. ⁶¹	van Dijk ST...Smedh K	32073652	2020
10	Utility of point-of-care ultrasound in patients with suspected diverticulitis in the emergency department. ⁶¹	Shokoohi H...Boniface K	32357249	2020
11	Can we better predict readmission for dehydration following creation of a diverting loop ileostomy: development and validation of a prediction model and web-based risk calculator. ⁶¹	Alqahtani M...Boutros M	31451920	2020
12	Initial clinical experience of single-incision robotic colorectal surgery with da Vinci SP platform. ⁶¹	Noh GT...Kim KH	32048755	2020
13	Emergency CT of abdominal complications of ingested fish bones: what not to miss. ⁶¹	E Silva GS...D'Ippolito G	32504281	2020
14	Study protocol for daiobotanpito combined with antibiotic therapy for treatment of acute diverticulitis: a study protocol for a randomized controlled trial. ⁶¹	Ogawa-Ochiai K...Ishikawa H	32546262	2020
15	Systematic review and meta-analysis comparing primary resection and anastomosis versus Hartmann's procedure for the management of acute perforated diverticulitis with generalised peritonitis. ⁶¹	Ryan OK...Winter DC	32124112	2020
16	Sigmoid resection with primary anastomosis versus the Hartmann's procedure for perforated diverticulitis with purulent or fecal peritonitis: a systematic review and meta-analysis. ⁶¹	Lambrichts DP...Lange JF	32504331	2020
17	Comparison of American Association for the Surgery of Trauma grading scale with modified Hinchey classification in acute colonic diverticulitis: A pilot study. ⁶¹	Ebersole J...Dennis B	32118825	2020
18	Cost-effectiveness of sigmoid resection with primary anastomosis or end colostomy for perforated diverticulitis: an analysis of the randomized Ladies trial. ⁶¹	Lambrichts DPV...Lange JF	32521053	2020
19	Opportunistic use of radiological measures of visceral adiposity for assessment of risk of colorectal adenoma. ⁶¹	Ng ZQ...Theophilus M	32501646	2020
20	Segmental colectomy for ulcerative colitis: is there a place in selected patients without active colitis ? An international multicentric retrospective study in 72 patients. ⁶¹	Frontali A...Panis Y	32498084	2020
21	Distinguishing features between patients with acute diverticulitis and diverticular bleeding: Results from the REMAD registry. ⁶¹	Carabotti M...REMAD group	32553704	2020
22	Computed tomography diagnosed first time diverticulitis and colorectal cancer. ⁶¹	Fogelstrom A...Pekkari K	32524190	2020
23	Human neutrophils activated by TLR8 agonists, with or without IFNγ, synthesize and release EBI3, but not IL-12, IL-27, IL-35, or IL-39. ⁶¹	Cassatella MA...Tamassia N	32480433	2020
24	Comparison of clinical and pathological findings of patients undergoing elective colectomy for uncomplicated diverticulitis. ⁶¹	Pesce A...Puleo S	32483125	2020
25	Acute Colonic Diverticulitis and Cirrhosis: Outcomes of Laparoscopic Colectomy Compared with an Open Approach. ⁶¹	Kazi A...Coimbra R	32229299	2020
26	Acute diverticulitis: old challenge, current trends, open questions. ⁶¹	Costi R...Violi V	32550727	2020
27	Acute Diverticulitis in Elderly Patients: Does Age Really Matter? ⁶¹	Covino M...Alfieri S	32485716	2020
28	Dietary Fiber and the Risk of Acute Diverticulitis. ⁶¹	Fung BM...Tabibian JH	31913190	2020
29	Diagnosis of appendiceal diverticulitis by multidetector computed tomography. ⁶¹	Fukata K...Fujino M	32172468	2020
30	Safety and efficacy of outpatient management for elderly patients with uncomplicated acute diverticulitis. ⁶¹	Juszczyk K...Hollington P	32199730	2020
31	Management of acute perforated diverticulitis with generalized peritonitis: is this the end of the Hartmann's era? ⁶¹	Binda GA	32277305	2020
32	Short- and Long-Term Outcomes of Right-Sided Diverticulitis: Over 15 Years of North American Experience. ⁶¹	Zuckerman J...Boutros M	32100064	2020
33	Disparities influencing rates of urgent/emergent surgery for diverticulitis in the state of Florida. ⁶¹	Lemini R...Colibaseanu DT	31526510	2020
34	Should diverticulitis be managed in primary care? An audit on the management of diverticulitis in primary care. ⁶¹	Kiandee M...Sripada R	32554687	2020
35	Validation of the Adapted Clavien-Dindo in Trauma (ACDiT) Classifications in Medical and Surgical Management of Acute Diverticulitis. ⁶¹	Wei S...Kao LS	32568744	2020
36	Surgical resection for diverticulitis using robotic natural orifice intracorporeal anastomosis and transrectal extraction approach: the NICE procedure. ⁶¹	Minjares RO...Haas EM	31506878	2020
37	The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Left-Sided Colonic Diverticulitis. ⁶¹	Hall J...Prepared on behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons	32384404	2020
38	Task-based characterization of a deep learning image reconstruction and comparison with filtered back-projection and a partial model-based iterative reconstruction in abdominal CT: A phantom study. ⁶¹	Racine D...Rotzinger DC	32574999	2020
39	No need to watch the clock: persistence during laparoscopic sigmoidectomy for diverticular disease. ⁶¹	Williams J...Valente M	32556770	2020
40	Pseudosarcomatous myofibroblastic proliferation of the appendix with an abdominal abscess due to diverticulum perforation: a case report. ⁶¹	Tanaka T...Yoshimura A	32572649	2020
41	The retro-ileal pull-through technique for colorectal and coloanal anastomosis. ⁶¹	Kent I...Wexner SD	32506342	2020
42	A systematic review and meta-analysis of disease severity and risk of recurrence in young versus elderly patients with left-sided acute diverticulitis. ⁶¹	van Dijk ST...Boermeester MA	31972659	2020
43	Can American College of Surgeons NSQIP Data Tell Whether We are Using Hartmann's or Primary Anastomosis for Emergent Surgical Management of Acute Diverticulitis?: In Reply to Garfinkle and Boutros. ⁶¹	Lee JM...Kaafarani H	32334745	2020
44	Systematic Review and Meta-analysis on Colorectal Cancer Findings on Colonic Evaluation After CT-Confirmed Acute Diverticulitis. ⁶¹	Koo CH...Mathew R	32271220	2020
45	Swiss experience of atezolizumab for platinum-pretreated urinary tract carcinoma: the SAUL study in real-world practice. ⁶¹	Cathomas R...Stenner F	32399958	2020
46	Expression of CA2 and CA9 carbonic anhydrases in ulcerative colitis and ulcerative colitis-associated colorectal cancer. ⁶¹	Nakada N...Murakumo Y	32410301	2020
47	Robotic Inguinal Hernia Repair. ⁶¹	Edelman DS	32432334	2020
48	Imaging Findings of Acute Abdomen due to Complications of Meckel Diverticulum. ⁶¹	Ichikawa S...Motosugi U	32063019	2020
49	The safety of baricitinib in patients with rheumatoid arthritis. ⁶¹	Honda S...Harigai M	32174196	2020
50	Hot Pockets: The Adverse Admixture of Obesity and Diverticulitis. ⁶¹	Rangan V...Nee J	32382900	2020

Sources

Genes for Diverticulitis

Genes related to Diverticulitis (0 elite genes):

(show all 25)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	FAM155A	Family With Sequence Similarity 155 Member A	Protein Coding	13.06	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	TNF	Tumor Necrosis Factor	Protein Coding	12.66	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	LAMB4	Laminin Subunit Beta 4	Protein Coding	12.64	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	TNFSF15	TNF Superfamily Member 15	Protein Coding	12.19	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	ARHGAP15	Rho GTPase Activating Protein 15	Protein Coding	12.08	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	COLQ	Collagen Like Tail Subunit Of Asymmetric Acetylcholinesterase	Protein Coding	11.63	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	FGF2	Fibroblast Growth Factor 2	Protein Coding	10.55	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	MMP9	Matrix Metallopeptidase 9	Protein Coding	10.53	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	SDC1	Syndecan 1	Protein Coding	10.33	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	9.71	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	TNFRSF18	TNF Receptor Superfamily Member 18	Protein Coding	9.68	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	CRP	C-Reactive Protein	Protein Coding	7.63	DISEASES inferred ¹⁵
13	ACADS	Acyl-CoA Dehydrogenase Short Chain	Protein Coding	6.95	DISEASES inferred ¹⁵
14	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	6.91	DISEASES inferred ¹⁵ ¹⁵
15	RIOK3	RIO Kinase 3	Protein Coding	6.7	DISEASES inferred ¹⁵
16	APOLD1	Apolipoprotein L Domain Containing 1	Protein Coding	6.67	DISEASES inferred ¹⁵
17	PHGR1	Proline, Histidine And Glycine Rich 1	Protein Coding	6.32	DISEASES inferred ¹⁵
18	S100A9	S100 Calcium Binding Protein A9	Protein Coding	6.3	GeneCards inferred via : Publications (show sections)
19	ATP12A	ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit	Protein Coding	6.29	DISEASES inferred ¹⁵
20	SERPINA1	Serpin Family A Member 1	Protein Coding	6.29	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	1725848
21	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	6.28	DISEASES inferred ¹⁵
22	DCXR	Dicarbonyl And L-Xylulose Reductase	Protein Coding	6.24	DISEASES inferred ¹⁵
23	MMP13	Matrix Metallopeptidase 13	Protein Coding	5.93	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	11686522
24	IL6	Interleukin 6	Protein Coding	5.93	DISEASES inferred ¹⁵
25	ALB	Albumin	Protein Coding	5.86	DISEASES inferred ¹⁵

Sources

Variations for Diverticulitis

Sources

Expression for Diverticulitis

Search GEO for disease gene expression data for Diverticulitis.

Sources

Pathways for Diverticulitis

Pathways related to Diverticulitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	11.79	TNF S100A9 MUC5AC MMP9
2	Proteoglycans in cancer ³⁶	11.57	TNF SDC1 MMP9 FGF2
3	TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions ⁶⁴ Show member pathways TNFs bind their physiological receptors ⁶⁵	11.35	TNFSF15 TNFRSF18 TNF
4	Lung fibrosis ¹	10.72	TNF SERPINA1 MMP9 FGF2

Sources

GO Terms for Diverticulitis

Cellular components related to Diverticulitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.61	TNFSF15 TNF SERPINA1 S100A9 MUC5AC MMP9
2	extracellular region	GO:0005576	9.4	TNFSF15 TNFRSF18 TNF SERPINA1 SDC1 S100A9

Biological processes related to Diverticulitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix organization	GO:0030198	9.56	TNF MMP9 FGF2 COLQ
2	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:0006919	9.5	TNFSF15 TNF S100A9
3	leukocyte migration involved in inflammatory response	GO:0002523	9.16	S100A9 CCR6
4	negative regulation of lipid storage	GO:0010888	8.96	TNF CRP
5	positive regulation of vascular smooth muscle cell proliferation	GO:1904707	8.8	TNF MMP9 FGF2

Sources

Sources for Diverticulitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Diverticulitis

Aliases & Classifications for Diverticulitis

MalaCards integrated aliases for Diverticulitis:

Classifications:

External Ids:

Summaries for Diverticulitis

Related Diseases for Diverticulitis

Diseases related to Diverticulitis via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Diverticulitis:

Symptoms & Phenotypes for Diverticulitis

Drugs & Therapeutics for Diverticulitis

Drugs for Diverticulitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Cochrane evidence based reviews: diverticulitis

Genetic Tests for Diverticulitis

Anatomical Context for Diverticulitis

MalaCards organs/tissues related to Diverticulitis:

Publications for Diverticulitis

Articles related to Diverticulitis:

Genes for Diverticulitis

Genes related to Diverticulitis (0 elite genes):

Variations for Diverticulitis

Expression for Diverticulitis

Pathways for Diverticulitis

Pathways related to Diverticulitis according to GeneCards Suite gene sharing:

GO Terms for Diverticulitis

Cellular components related to Diverticulitis according to GeneCards Suite gene sharing:

Biological processes related to Diverticulitis according to GeneCards Suite gene sharing:

Sources for Diverticulitis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :