MCID: DVR001
MIFTS: 24

Diverticulitis of Colon

Categories: Gastrointestinal diseases

Aliases & Classifications for Diverticulitis of Colon

MalaCards integrated aliases for Diverticulitis of Colon:

Name: Diverticulitis of Colon 12 15
Diverticular Disease of Colon 71
Colonic Diverticular Disease 12
Diverticulitis, Colonic 44

Classifications:



External Ids:

Disease Ontology 12 DOID:13254
MeSH 44 D004239
SNOMED-CT 67 111359004
UMLS 71 C0012814 C0012819

Summaries for Diverticulitis of Colon

Disease Ontology : 12 A colonic disease characterized by the formation and inflammation of diverticula within the colon wall.

MalaCards based summary : Diverticulitis of Colon, also known as diverticular disease of colon, is related to diverticulitis and constipation. An important gene associated with Diverticulitis of Colon is PHGR1 (Proline, Histidine And Glycine Rich 1). The drugs Ertapenem and Methadone have been mentioned in the context of this disorder. Affiliated tissues include colon.

Related Diseases for Diverticulitis of Colon

Diseases related to Diverticulitis of Colon via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 diverticulitis 29.2 PHGR1 LAMB4 FAM155A CRP ARHGAP15
2 constipation 10.3
3 irritable bowel syndrome 10.3
4 colorectal adenoma 10.1
5 polycystic kidney disease 10.1
6 kidney disease 10.1
7 adenoma 10.1
8 intestinal obstruction 10.1
9 ileus 10.1
10 autosomal dominant polycystic kidney disease 10.1
11 peritonitis 10.1
12 colorectal cancer 10.0
13 celiac disease 1 10.0
14 helicobacter pylori infection 10.0
15 cardiac conduction disease with or without dilated cardiomyopathy 10.0
16 inflammatory bowel disease 10.0
17 urinary tract infection 10.0
18 diarrhea 10.0
19 toxic shock syndrome 10.0
20 basal cell carcinoma 10.0
21 lipomatosis 10.0
22 intestinal disease 10.0
23 end stage renal disease 10.0
24 appendicitis 10.0
25 paralytic ileus 10.0
26 actinomycosis 10.0
27 ulcerative colitis 10.0
28 vasculitis 10.0
29 overgrowth syndrome 10.0
30 urticaria 9.9
31 crohn's disease 9.9
32 migraine with or without aura 1 9.7 CRP CALCB

Graphical network of the top 20 diseases related to Diverticulitis of Colon:



Diseases related to Diverticulitis of Colon

Symptoms & Phenotypes for Diverticulitis of Colon

Drugs & Therapeutics for Diverticulitis of Colon

Drugs for Diverticulitis of Colon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
2
Methadone Approved Phase 4 76-99-3 4095
3
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
4
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
5
Acetaminophen Approved Phase 4 103-90-2 1983
6
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
7
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
8
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
9
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
10
Morphine Approved, Investigational Phase 4 57-27-2 5288826
11
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
12
Orphenadrine Approved Phase 4 83-98-7 4601
13
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
14
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
15
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
16 Ketorolac Tromethamine Phase 4
17 Parasympatholytics Phase 4
18 Respiratory System Agents Phase 4
19 Anesthetics Phase 4
20 Anti-Inflammatory Agents Phase 4
21 Anticonvulsants Phase 4
22 Narcotics Phase 4
23 Cytochrome P-450 Enzyme Inhibitors Phase 4
24 Sodium Channel Blockers Phase 4
25 Analgesics, Non-Narcotic Phase 4
26 Cyclooxygenase Inhibitors Phase 4
27 Acetaminophen, hydrocodone drug combination Phase 4
28 Antiparkinson Agents Phase 4
29 Analgesics, Opioid Phase 4
30 Muscarinic Antagonists Phase 4
31 Anti-Inflammatory Agents, Non-Steroidal Phase 4
32 Excitatory Amino Acid Antagonists Phase 4
33 Cholinergic Antagonists Phase 4
34 Anesthetics, Dissociative Phase 4
35 Antitussive Agents Phase 4
36 Neurotransmitter Agents Phase 4
37 Analgesics Phase 4
38 Psychotropic Drugs Phase 4
39 Anesthetics, Local Phase 4
40 Diuretics, Potassium Sparing Phase 4
41 Antirheumatic Agents Phase 4
42 Anesthetics, Intravenous Phase 4
43 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
44 Anti-Anxiety Agents Phase 4
45 Anesthetics, General Phase 4
46 Antipyretics Phase 4
47 Anti-Arrhythmia Agents Phase 4
48 Cholinergic Agents Phase 4
49
Methylene blue Approved, Investigational 61-73-4
50 Anti-Infective Agents

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 A Prospective, Multicenter, Open-Label, Randomized Clinical Study to Evaluate the Duration of Treatment With Ertapenem in Acute Attacks of Sigmoid Diverticulitis Unknown status NCT00097734 Phase 4 ertapenem
2 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery as Part of an Enhanced Recovery After Surgery Protocol: A Randomized Prospective Single- Center Trial. Unknown status NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
3 Hartmann vs Resection With Anastomosis and Diverting Stoma for Peritonitis Caused by Perforated Left-sided Colon Diverticulitis: a Multicenter Prospective Randomized Study. Completed NCT01239927 Phase 2, Phase 3
4 Randomized Multicentric Controlled Clinical Trial of Parallel Groups to Evaluate the Non-therapeutic Inferiority of a Free Diet With a Progressive Diet, in the Treatment of Non-complicated Acute Diverticulitis Completed NCT03496090
5 Multicentric Point of Care UltraSound by Surgeons Trial Completed NCT02682368
6 Management of Patients With Uncomplicated Diverticulitis as Out-patient and Without Antibiotics Completed NCT01515150
7 Operative and Conservative Treatment in Right Colon Diverticulitis Patients Completed NCT04746326
8 Is Antibiotic Therapy Mandatory for Treatment of Uncomplicated Acute Colonic Diverticulitis: a Randomized Clinical Trial Completed NCT01008488 Antibiotic
9 PREDICtors for Health Related Quality of Life After Elective Sigmoidectomy for DIVerticular Disease: The PREDIC-DIV Study Recruiting NCT03527706
10 Prevalence of Segmental Colitis Associated With Colic Diverticulosis (SCAD): an Observational Study Recruiting NCT04279821
11 Clinical Trial for the Determination of Advanced Colonic Neoplasia Prevalence and the Need for Colonoscopy in Complicated and Uncomplicated Acute Diverticulitis Recruiting NCT03557216
12 Scandinavian Diverticulitis Trial SCANDIV II: Treatment of Acute Complicated Diverticulitis: a Prospective Observational Study Recruiting NCT04254224
13 Management and Evolution of Acute Diverticulitis With Pericolic Free Gas - a Multicentre Observational Study Recruiting NCT04311385
14 Prospective and Multicentre Study on Clinical-biological Factors Predictive of Chronic Colon DIverticulitis Recruiting NCT04407793
15 Safety and Feasibility of ActivSightTM Laser Speckle Imaging in Visualization of Tissue Perfusion and Vasculature in Human Enrolling by invitation NCT04633512
16 Intraoperative Testing of Colorectal Anastomosis - Air or Water (Methylene Blue)? Not yet recruiting NCT03316677
17 Seal-G MIST System Safety Study [SEALAR Study] Withdrawn NCT03448874

Search NIH Clinical Center for Diverticulitis of Colon

Cochrane evidence based reviews: diverticulitis, colonic

Genetic Tests for Diverticulitis of Colon

Anatomical Context for Diverticulitis of Colon

MalaCards organs/tissues related to Diverticulitis of Colon:

40
Colon

Publications for Diverticulitis of Colon

Articles related to Diverticulitis of Colon:

(show all 23)
# Title Authors PMID Year
1
Laparoscopic lavage and drainage for Hinchey III diverticulitis: review of technical aspects. 61
30097970 2019
2
Pharmacobezoar: An Unusual Cause of Large Bowel Obstruction. 61
29118874 2017
3
William Arbuthnot Lane (1856-1943): Surgical Innovator and His Theory of Autointoxication. 61
28234103 2017
4
Contemporary Review of Risk-Stratified Management in Acute Uncomplicated and Complicated Diverticulitis. 61
27206400 2016
5
Diverticulosis and Diverticulitis. 61
27156370 2016
6
A comparison of outcomes of emergent, urgent, and elective surgical treatment of diverticulitis. 61
26116319 2015
7
Experience of managing complicated diverticulitis of colon: a retrospective case series from South Asian country. 61
24864634 2014
8
Resection and primary anastomosis in acute complicated diverticulitis, a systematic review of the literature. 61
16437211 2007
9
Long-term treatment with mesalazine and rifaximin versus rifaximin alone for patients with recurrent attacks of acute diverticulitis of colon. 61
12236485 2002
10
[Standardization in sigmoid diverticulitis surgery planning: indications based on evaluation with the Hughes classification]. 61
9574354 1997
11
Unusual cases of perforated diverticulitis of colon. 61
2230705 1990
12
[A case of vesicosigmoidal fistula secondary to diverticulitis of the colon]. 61
3618434 1987
13
Case profile: unique uroradiographic manifestation of diverticulitis of colon. 61
7112836 1982
14
[Colonic localization of Crohn's disease. New case reports. Rectocolic Crohn's disease. Colonic Crohn's disease and sigmoid diverticulitis. Colonic Crohn's disease]. 61
5562841 1971
15
[Diverticulitis, colonic diverticulosis]. 61
5772002 1969
16
GENERALIZED PERITONITIS COMPLICATING ACUTE DIVERTICULITIS OF COLON. 61
14236316 1965
17
Surgical management in complications of diverticulitis of colon. 61
13661559 1959
18
[Diverticulitis of colon]. 61
13375325 1956
19
Diverticulitis of colon and new aspects of its treatment with report of five cases. 61
14393950 1955
20
Surgical treatment of diverticulitis of colon. 61
13227745 1955
21
[Anatomopathological and clinical experiences with stenotic diverticulitis of colon, with special reference to therapeutic problems]. 61
13331051 1955
22
Intestinovesical fistula Report of three cases resulting from diverticulitis of colon. 61
14817551 1951
23
[Clinical aspects of diverticulitis of colon and sigmoid]. 61
14800610 1950

Variations for Diverticulitis of Colon

Expression for Diverticulitis of Colon

Search GEO for disease gene expression data for Diverticulitis of Colon.

Pathways for Diverticulitis of Colon

GO Terms for Diverticulitis of Colon

Sources for Diverticulitis of Colon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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