Diverticulitis of Colon disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: DVR001 MIFTS: 34	Diverticulitis of Colon Categories: Gastrointestinal diseases
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Aliases & Classifications for Diverticulitis of Colon

MalaCards integrated aliases for Diverticulitis of Colon:

Name: Diverticulitis of Colon ¹² ¹⁵

Diverticular Disease of Colon ⁷³

Colonic Diverticular Disease ¹²

Diverticulitis, Colonic ⁴⁴

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:13254

ICD9CM ³⁵ 562.12

MeSH ⁴⁴ D004239

UMLS ⁷³ C0156168 C0012819

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Summaries for Diverticulitis of Colon

Disease Ontology : ¹² A colonic disease characterized by the formation and inflammation of diverticula within the colon wall.

MalaCards based summary : Diverticulitis of Colon, also known as diverticular disease of colon, is related to diverticulitis and autoimmune encephalitis. An important gene associated with Diverticulitis of Colon is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1). The drugs Acetaminophen and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and testes, and related phenotypes are behavior/neurological and integument

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Related Diseases for Diverticulitis of Colon

Diseases related to Diverticulitis of Colon via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)

#	Related Disease	Score	Top Affiliating Genes
1	diverticulitis	31.1	ACADS DCXR
2	autoimmune encephalitis	10.5	CNR1 TRPV1
3	lacrimal apparatus disease	10.5	DCXR TRPV1
4	dental pulp disease	10.4	NPS TRPV1
5	pain agnosia	10.3	CNR1 TRPV1
6	agnosia	10.3	CNR1 TRPV1
7	indeterminate leprosy	10.2	NPS UCHL1
8	spinocerebellar ataxia 23	10.1	NPS TACR1
9	nasal cavity disease	10.1	NPS TRPV1
10	neurogenic bowel	10.1	DCXR KIT
11	retinitis pigmentosa 68	10.1	NPS TACR1
12	testicular infarct	10.1	KIT UCHL1
13	disease of mental health	10.0	CNR1 NPS TRPV1
14	malignant mesenchymoma	9.9	KIT UCHL1
15	perry syndrome	9.8	NPS TACR1
16	connective tissue cancer	9.7	KIT TRPV1
17	peritonitis	9.7
18	enterovesical fistula	9.7
19	cystitis	9.6	TACR1 TRPV1
20	migraine with or without aura 1	9.3	CNR1 NPS TACR1 TRPV1

Graphical network of the top 20 diseases related to Diverticulitis of Colon:

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Symptoms & Phenotypes for Diverticulitis of Colon

MGI Mouse Phenotypes related to Diverticulitis of Colon:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.7	ACADS BRD2 CNR1 KIT TACR1 TRPV1
2	integument	MP:0010771	9.43	UCHL1 ACADS CNR1 KIT TACR1 TRPV1
3	liver/biliary system	MP:0005370	9.02	ACADS BRD2 KIT TRPV1 UCHL1

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Drugs & Therapeutics for Diverticulitis of Colon

Drugs for Diverticulitis of Colon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Acetaminophen

Approved

Phase 4

103-90-2

1983

Bupivacaine

Approved, Investigational

Phase 4

2180-92-9, 38396-39-3

2474

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 4

437-38-7

3345

Gabapentin

Approved, Investigational

Phase 4

60142-96-3

3446

Guaifenesin

Approved, Investigational, Vet_approved

Phase 4

93-14-1

3516

Hydrocodone

Approved, Illicit

Phase 4

125-29-1

5284569

Hydromorphone

Approved, Illicit

Phase 4

466-99-9

5284570

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1

3821

Ketorolac

Approved

Phase 4

74103-06-3, 66635-83-4

3826

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Methadone

Approved

Phase 4

76-99-3

4095

Morphine

Approved, Investigational

Phase 4

57-27-2

5288826

Orphenadrine

Approved

Phase 4

83-98-7

4601

Oxycodone

Approved, Illicit, Investigational

Phase 4

76-42-6

5284603

Tramadol

Approved, Investigational

Phase 4

27203-92-5

33741

Acetaminophen, hydrocodone drug combination

Phase 4

Adjuvants, Anesthesia

Phase 4

Analgesics

Phase 4

Analgesics, Non-Narcotic

Phase 4

Analgesics, Opioid

Phase 4

Anesthetics

Phase 4

Anesthetics, Dissociative

Phase 4

Anesthetics, General

Phase 4

Anesthetics, Intravenous

Phase 4

Anesthetics, Local

Phase 4

Anti-Anxiety Agents

Phase 4

Anti-Arrhythmia Agents

Phase 4

Anticonvulsants

Phase 4

Anti-Inflammatory Agents

Phase 4

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

Antimanic Agents

Phase 4

Antiparkinson Agents

Phase 4

Antipyretics

Phase 4

Antirheumatic Agents

Phase 4

Antitussive Agents

Phase 4

Autonomic Agents

Phase 4

calcium channel blockers

Phase 4

Calcium, Dietary

Phase 4

Central Nervous System Depressants

Phase 4

Chlorpheniramine, phenylpropanolamine drug combination

Phase 4

Cholinergic Agents

Phase 4

Cholinergic Antagonists

Phase 4

Cyclooxygenase Inhibitors

Phase 4

Cytochrome P-450 Enzyme Inhibitors

Phase 4

Diuretics, Potassium Sparing

Phase 4

Excitatory Amino Acid Antagonists

Phase 4

Excitatory Amino Acids

Phase 4

Ketorolac Tromethamine

Phase 4

Muscarinic Antagonists

Phase 4

Narcotics

Phase 4

Interventional clinical trials:

(show all 13)

#	Name	Status	NCT ID	Phase	Drugs
1	Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery	Recruiting	NCT02958566	Phase 4	Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
2	Hartmann vs R/A in Peritonitis by Perforated Diverticulitis	Completed	NCT01239927	Phase 2, Phase 3
3	Antibiotic Therapy of Acute Uncomplicated Colonic Diverticulitis	Completed	NCT01008488	Not Applicable	Antibiotic
4	The Out-patient, Non Antibiotic Management of Patients With Acute Uncomplicated Colonic Diverticulitis	Completed	NCT01515150
5	Occult Obscure Gastrointestinal Bleeding	Completed	NCT03464539	Not Applicable
6	Primary vs. Secondary Anastomosis for Hinchey Stage III-IV Diverticulitis a Prospective Randomized Trial	Completed	NCT00692393	Not Applicable
7	Colonic Resections in Patients With Suspected Appendicitis	Completed	NCT00888888
8	Prevalence of Colon Cancer in Pyogenic Liver Abscess	Completed	NCT02032914
9	Diagnostic Accuracy of Bedside Ultrasound in Suspected Acute Diverticulitis	Recruiting	NCT03279588
10	Laparoscopic-lavage Observational Study	Recruiting	NCT02662088
11	Laparoscopic Peritoneal Lavage vs Laparoscopic Sigmoidectomy in Perforated Acute Diverticulitis: a Multicenter Prospective Observational Study (STELLA Study)	Recruiting	NCT03008707
12	Seal-G MIST (Minimally Invasive Sealant/Spray Technology) System Safety Study [SEALAR Study]	Not yet recruiting	NCT03448874	Not Applicable
13	Intraoperative Testing of Colorectal Anastomosis - Air or Water (Methylene Blue)?	Not yet recruiting	NCT03316677	Not Applicable

Search NIH Clinical Center for Diverticulitis of Colon

Cochrane evidence based reviews: diverticulitis, colonic

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Genetic Tests for Diverticulitis of Colon

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Anatomical Context for Diverticulitis of Colon

MalaCards organs/tissues related to Diverticulitis of Colon:

⁴¹

Colon, Liver, Testes

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Publications for Diverticulitis of Colon

Articles related to Diverticulitis of Colon:

#	Title	Authors	Year
1	Experience of managing complicated diverticulitis of colon: a retrospective case series from South Asian country. ( 24864634 )	Gala T....Mirza M.	2014
2	Long-term treatment with mesalazine and rifaximin versus rifaximin alone for patients with recurrent attacks of acute diverticulitis of colon. ( 12236485 )	Tursi A....DaffinA R.	2002
3	Unusual cases of perforated diverticulitis of colon. ( 2230705 )	Terry J.H.	1990
4	Case profile: unique uroradiographic manifestation of diverticulitis of colon. ( 7112836 )	Finan B.F....Redman J.F.	1982
5	GENERALIZED PERITONITIS COMPLICATING ACUTE DIVERTICULITIS OF COLON. ( 14236316 )	ARONSON A.R....Altman K.A.	1965
6	Surgical management in complications of diverticulitis of colon. ( 13661559 )	WHITLEY M.E.	1959
7	Surgical treatment of diverticulitis of colon. ( 13227745 )	GILCHRIST R.K....ECONOMOU S.	1955
8	Diverticulitis of colon and new aspects of its treatment with report of five cases. ( 14393950 )	PICARD H.N.	1955
9	Intestinovesical fistula Report of three cases resulting from diverticulitis of colon. ( 14817551 )	CONROY T.F.	1951

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Genes for Diverticulitis of Colon

Genes related to Diverticulitis of Colon (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TRPV1	Transient Receptor Potential Cation Channel Subfamily V Member 1	Protein Coding	18.7	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	ACADS	Acyl-CoA Dehydrogenase Short Chain	Protein Coding	15.48	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	DCXR	Dicarbonyl And L-Xylulose Reductase	Protein Coding	14.64	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	CD1A	CD1a Molecule	Protein Coding	14.23	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	UCHL1	Ubiquitin C-Terminal Hydrolase L1	Protein Coding	14.22	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	CNR1	Cannabinoid Receptor 1	Protein Coding	14.19	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	NPS	Neuropeptide S	Protein Coding	14.15	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	BRD2	Bromodomain Containing 2	Protein Coding	13.87	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	KIT	KIT Proto-Oncogene Receptor Tyrosine Kinase	Protein Coding	13.28	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	STC1	Stanniocalcin 1	Protein Coding	5.12	DISEASES inferred ¹⁵
11	TACR1	Tachykinin Receptor 1	Protein Coding	4.73	DISEASES inferred ¹⁵

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Variations for Diverticulitis of Colon

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Expression for Diverticulitis of Colon

Search GEO for disease gene expression data for Diverticulitis of Colon.

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Pathways for Diverticulitis of Colon

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GO Terms for Diverticulitis of Colon

Cellular components related to Diverticulitis of Colon according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.02	CD1A CNR1 KIT TACR1 TRPV1

Biological processes related to Diverticulitis of Colon according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	learning or memory	GO:0007611	9.52	CNR1 TACR1
2	response to heat	GO:0009408	9.51	TACR1 TRPV1
3	visual learning	GO:0008542	9.49	KIT NPS
4	response to nicotine	GO:0035094	9.48	CNR1 TACR1
5	response to morphine	GO:0043278	9.46	CNR1 TACR1
6	eating behavior	GO:0042755	9.43	TACR1 UCHL1
7	positive regulation of blood pressure	GO:0045777	9.4	CNR1 TACR1
8	response to pain	GO:0048265	9.37	TACR1 TRPV1
9	positive regulation of synaptic transmission, GABAergic	GO:0032230	9.32	NPS TACR1
10	behavioral response to pain	GO:0048266	9.26	TACR1 TRPV1
11	positive regulation of action potential	GO:0045760	9.16	NPS TACR1
12	smooth muscle contraction involved in micturition	GO:0060083	8.96	TACR1 TRPV1
13	sensory perception of pain	GO:0019233	8.92	CNR1 TACR1 TRPV1 UCHL1

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Sources for Diverticulitis of Colon

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