Diverticulitis of Colon disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: DVR001 MIFTS: 29	Diverticulitis of Colon Categories: Gastrointestinal diseases
Genes Tissues Related diseases Publications Drugs Expand all tables

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Aliases & Classifications for Diverticulitis of Colon

MalaCards integrated aliases for Diverticulitis of Colon:

Name: Diverticulitis of Colon ¹² ¹⁵

Diverticular Disease of Colon ⁷³

Colonic Diverticular Disease ¹²

Diverticulitis, Colonic ⁴⁴

Classifications:

MalaCards categories:
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:13254

MeSH ⁴⁴ D004239

UMLS ⁷³ C0012814 C0012819

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Summaries for Diverticulitis of Colon

Disease Ontology : ¹² A colonic disease characterized by the formation and inflammation of diverticula within the colon wall.

MalaCards based summary : Diverticulitis of Colon, also known as diverticular disease of colon, is related to diverticulitis and autoimmune encephalitis. An important gene associated with Diverticulitis of Colon is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1). The drugs Guaifenesin and Ketorolac have been mentioned in the context of this disorder. Affiliated tissues include colon and bone, and related phenotypes are behavior/neurological and homeostasis/metabolism

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Related Diseases for Diverticulitis of Colon

Diseases related to Diverticulitis of Colon via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)

#	Related Disease	Score	Top Affiliating Genes
1	diverticulitis	30.8	ACADS DCXR
2	autoimmune encephalitis	10.2	CNR1 TRPV1
3	lacrimal apparatus disease	10.2	DCXR TRPV1
4	dental pulp disease	10.2	NPS TRPV1
5	pain agnosia	10.1	CNR1 TRPV1
6	agnosia	10.1	CNR1 TRPV1
7	indeterminate leprosy	10.1	NPS UCHL1
8	cardiovascular organ benign neoplasm	10.1	KIT TRPV1
9	benign perivascular tumor	10.1	KIT TRPV1
10	neurogenic bowel	10.1	DCXR KIT
11	testicular infarct	10.1	KIT UCHL1
12	nervous system benign neoplasm	10.1	KIT TRPV1
13	nasal cavity disease	10.1	NPS TRPV1
14	nose disease	10.1	NPS TRPV1
15	disease of mental health	10.0	CNR1 NPS TRPV1
16	malignant mesenchymoma	10.0	KIT UCHL1
17	connective tissue cancer	10.0	KIT TRPV1
18	spinocerebellar ataxia 23	10.0	NPS TACR1
19	retinitis pigmentosa 68	10.0	NPS TACR1
20	diabetic neuropathy	10.0	CNR1 TRPV1
21	colorectal cancer	9.9
22	helicobacter pylori infection	9.9
23	irritable bowel syndrome	9.9
24	causalgia	9.9	NPS TACR1
25	peritonitis	9.9
26	enterovesical fistula	9.9
27	perry syndrome	9.8	NPS TACR1
28	migraine with or without aura 1	9.5	CALCRL CNR1 NPS TACR1 TRPV1

Graphical network of the top 20 diseases related to Diverticulitis of Colon:

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Symptoms & Phenotypes for Diverticulitis of Colon

MGI Mouse Phenotypes related to Diverticulitis of Colon:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.87	ACADS BRD2 CNR1 KIT TACR1 TRPV1
2	homeostasis/metabolism	MP:0005376	9.86	ACADS BRD2 CALCRL CNR1 KIT TACR1
3	integument	MP:0010771	9.7	ACADS CALCRL CNR1 KIT TACR1 TRPV1
4	liver/biliary system	MP:0005370	9.35	ACADS BRD2 KIT TRPV1 UCHL1
5	renal/urinary system	MP:0005367	9.02	ACADS BRD2 KIT TRPV1 UCHL1

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Drugs & Therapeutics for Diverticulitis of Colon

Drugs for Diverticulitis of Colon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Guaifenesin

Approved, Investigational, Vet_approved

Phase 4

93-14-1

3516

Ketorolac

Approved

Phase 4

66635-83-4, 74103-06-3

3826

Tramadol

Approved, Investigational

Phase 4

27203-92-5

33741

Oxycodone

Approved, Illicit, Investigational

Phase 4

76-42-6

5284603

Orphenadrine

Approved

Phase 4

83-98-7

4601

Gabapentin

Approved, Investigational

Phase 4

60142-96-3

3446

Morphine

Approved, Investigational

Phase 4

57-27-2

5288826

Fentanyl

Approved, Illicit, Investigational, Vet_approved

Phase 4

437-38-7

3345

Hydromorphone

Approved, Illicit

Phase 4

466-99-9

5284570

Ketamine

Approved, Vet_approved

Phase 4

6740-88-1

3821

Hydrocodone

Approved, Illicit, Investigational

Phase 4

125-29-1

5284569

Bupivacaine

Approved, Investigational

Phase 4

2180-92-9, 38396-39-3

2474

Acetaminophen

Approved

Phase 4

103-90-2

1983

Lidocaine

Approved, Vet_approved

Phase 4

137-58-6

3676

Methadone

Approved

Phase 4

76-99-3

4095

Antipyretics

Phase 4

Antitussive Agents

Phase 4

Anti-Inflammatory Agents, Non-Steroidal

Phase 4

Adjuvants, Anesthesia

Phase 4

Anti-Arrhythmia Agents

Phase 4

Anesthetics, Dissociative

Phase 4

Cytochrome P-450 Enzyme Inhibitors

Phase 4

Ketorolac Tromethamine

Phase 4

Autonomic Agents

Phase 4

Cholinergic Antagonists

Phase 4

Anti-Anxiety Agents

Phase 4

Analgesics

Phase 4

Excitatory Amino Acids

Phase 4

calcium channel blockers

Phase 4

Anesthetics, Local

Phase 4

Parasympatholytics

Phase 4

Cyclooxygenase Inhibitors

Phase 4

Antiparkinson Agents

Phase 4

Anesthetics

Phase 4

Antirheumatic Agents

Phase 4

Acetaminophen, hydrocodone drug combination

Phase 4

Chlorpheniramine, phenylpropanolamine drug combination

Phase 4

Excitatory Amino Acid Antagonists

Phase 4

Diuretics, Potassium Sparing

Phase 4

Anti-Inflammatory Agents

Phase 4

Anesthetics, Intravenous

Phase 4

Central Nervous System Depressants

Phase 4

Sodium Channel Blockers

Phase 4

Narcotics

Phase 4

Tranquilizing Agents

Phase 4

Calcium, Dietary

Phase 4

Neuromuscular Agents

Phase 4

Neurotransmitter Agents

Phase 4

Cholinergic Agents

Phase 4

Analgesics, Opioid

Phase 4

Interventional clinical trials:

(show all 13)

#	Name	Status	NCT ID	Phase	Drugs
1	Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery	Recruiting	NCT02958566	Phase 4	Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
2	Hartmann vs R/A in Peritonitis by Perforated Diverticulitis	Completed	NCT01239927	Phase 2, Phase 3
3	Antibiotic Therapy of Acute Uncomplicated Colonic Diverticulitis	Completed	NCT01008488	Not Applicable	Antibiotic
4	The Out-patient, Non Antibiotic Management of Patients With Acute Uncomplicated Colonic Diverticulitis	Completed	NCT01515150
5	Occult Obscure Gastrointestinal Bleeding	Completed	NCT03464539	Not Applicable
6	Diagnostic Accuracy of Bedside Ultrasound in Suspected Acute Diverticulitis	Completed	NCT03279588
7	Primary vs. Secondary Anastomosis for Hinchey Stage III-IV Diverticulitis a Prospective Randomized Trial	Completed	NCT00692393	Not Applicable
8	Colonic Resections in Patients With Suspected Appendicitis	Completed	NCT00888888
9	Prevalence of Colon Cancer in Pyogenic Liver Abscess	Completed	NCT02032914
10	Laparoscopic-lavage Observational Study	Recruiting	NCT02662088
11	Laparoscopic Peritoneal Lavage vs Laparoscopic Sigmoidectomy in Perforated Acute Diverticulitis: a Multicenter Prospective Observational Study (STELLA Study)	Recruiting	NCT03008707
12	Seal-G MIST (Minimally Invasive Sealant/Spray Technology) System Safety Study [SEALAR Study]	Not yet recruiting	NCT03448874	Not Applicable
13	Intraoperative Testing of Colorectal Anastomosis - Air or Water (Methylene Blue)?	Not yet recruiting	NCT03316677	Not Applicable

Search NIH Clinical Center for Diverticulitis of Colon

Cochrane evidence based reviews: diverticulitis, colonic

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Genetic Tests for Diverticulitis of Colon

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Anatomical Context for Diverticulitis of Colon

MalaCards organs/tissues related to Diverticulitis of Colon:

⁴¹

Colon, Bone

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Publications for Diverticulitis of Colon

Articles related to Diverticulitis of Colon:

(show all 16)

#	Title	Authors	Year
1	LONG-TERM RESULTS OF SURGICAL TREATMENT OF DIVERTICULAR DISEASE OF COLON. ( 30427159 )	Pomazkin VI...Khodakov VV	2016
2	Experience of managing complicated diverticulitis of colon: a retrospective case series from South Asian country. ( 24864634 )	Gala T....Mirza M.	2014
3	Pathophysiological aspects of diverticular disease of colon and role of large bowel motility. ( 14562365 )	Bassotti G...Morelli A	2003
4	Long-term treatment with mesalazine and rifaximin versus rifaximin alone for patients with recurrent attacks of acute diverticulitis of colon. ( 12236485 )	Tursi A...Daffin? R	2002
5	Diverticular disease of colon; Indian variant. ( 1949209 )	Ibrarullah M...Awasthi S	1991
6	Unusual cases of perforated diverticulitis of colon. ( 2230705 )	Terry JH	1990
7	Dietary fibre and prevention of diverticular disease of colon: evidence from rats. ( 6146851 )	Berry CS...Hardy J	1984
8	Diverticular disease of colon in China. A 60-year retrospective study. ( 6437755 )	Pan GZ...Chang HC	1984
9	Case profile: unique uroradiographic manifestation of diverticulitis of colon. ( 7112836 )		1982
10	Emergency resection in treatment of diverticular disease of colon complicated by peritonitis. ( 5666803 )	Roxburgh RA...Yeo R	1968
11	GENERALIZED PERITONITIS COMPLICATING ACUTE DIVERTICULITIS OF COLON. ( 14236316 )	ARONSON A.R....Altman K.A.	1965
12	Surgical management in complications of diverticulitis of colon. ( 13661559 )		1959
13	Incidence and type of bleeding in diverticular disease of colon; analysis of 131 cases. ( 13609907 )	REIDER RA...MACK RE	1958
14	Surgical treatment of diverticulitis of colon. ( 13227745 )	GILCHRIST R.K....ECONOMOU S.	1955
15	Diverticulitis of colon and new aspects of its treatment with report of five cases. ( 14393950 )	PICARD H.N.	1955
16	Intestinovesical fistula Report of three cases resulting from diverticulitis of colon. ( 14817551 )	CONROY T.F.	1951

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Genes for Diverticulitis of Colon

Genes related to Diverticulitis of Colon (0 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TRPV1	Transient Receptor Potential Cation Channel Subfamily V Member 1	Protein Coding	18.56	DISEASES inferred ¹⁵ ¹⁵
2	ACADS	Acyl-CoA Dehydrogenase Short Chain	Protein Coding	15.38	DISEASES inferred ¹⁵
3	DCXR	Dicarbonyl And L-Xylulose Reductase	Protein Coding	14.5	DISEASES inferred ¹⁵
4	UCHL1	Ubiquitin C-Terminal Hydrolase L1	Protein Coding	14.14	DISEASES inferred ¹⁵
5	CNR1	Cannabinoid Receptor 1	Protein Coding	14.13	DISEASES inferred ¹⁵
6	CD1A	CD1a Molecule	Protein Coding	14.1	DISEASES inferred ¹⁵
7	NPS	Neuropeptide S	Protein Coding	14.08	DISEASES inferred ¹⁵
8	BRD2	Bromodomain Containing 2	Protein Coding	13.75	DISEASES inferred ¹⁵
9	KIT	KIT Proto-Oncogene Receptor Tyrosine Kinase	Protein Coding	13.16	DISEASES inferred ¹⁵
10	STC1	Stanniocalcin 1	Protein Coding	5.02	DISEASES inferred ¹⁵
11	TACR1	Tachykinin Receptor 1	Protein Coding	4.65	DISEASES inferred ¹⁵
12	CALCRL	Calcitonin Receptor Like Receptor	Protein Coding	3.82	DISEASES inferred ¹⁵

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Variations for Diverticulitis of Colon

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Expression for Diverticulitis of Colon

Search GEO for disease gene expression data for Diverticulitis of Colon.

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Pathways for Diverticulitis of Colon

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GO Terms for Diverticulitis of Colon

Cellular components related to Diverticulitis of Colon according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.1	CALCRL CD1A CNR1 KIT TACR1 TRPV1

Biological processes related to Diverticulitis of Colon according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	visual learning	GO:0008542	9.16	KIT NPS
2	response to pain	GO:0048265	8.96	TACR1 TRPV1
3	sensory perception of pain	GO:0019233	8.8	CNR1 TRPV1 UCHL1

Molecular functions related to Diverticulitis of Colon according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	transmembrane signaling receptor activity	GO:0004888	8.8	CALCRL KIT TRPV1

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Sources for Diverticulitis of Colon

¹ BioSystems

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³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

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⁴¹ MalaCards

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⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

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⁷⁶ Wikipedia