MCID: DVR001
MIFTS: 29

Diverticulitis of Colon

Categories: Gastrointestinal diseases

Aliases & Classifications for Diverticulitis of Colon

MalaCards integrated aliases for Diverticulitis of Colon:

Name: Diverticulitis of Colon 12 15
Diverticular Disease of Colon 73
Colonic Diverticular Disease 12
Diverticulitis, Colonic 44

Classifications:



External Ids:

Disease Ontology 12 DOID:13254
MeSH 44 D004239

Summaries for Diverticulitis of Colon

Disease Ontology : 12 A colonic disease characterized by the formation and inflammation of diverticula within the colon wall.

MalaCards based summary : Diverticulitis of Colon, also known as diverticular disease of colon, is related to diverticulitis and autoimmune encephalitis. An important gene associated with Diverticulitis of Colon is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1). The drugs Guaifenesin and Ketorolac have been mentioned in the context of this disorder. Affiliated tissues include colon and bone, and related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Diverticulitis of Colon

Graphical network of the top 20 diseases related to Diverticulitis of Colon:



Diseases related to Diverticulitis of Colon

Symptoms & Phenotypes for Diverticulitis of Colon

MGI Mouse Phenotypes related to Diverticulitis of Colon:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 ACADS BRD2 CNR1 KIT TACR1 TRPV1
2 homeostasis/metabolism MP:0005376 9.86 ACADS BRD2 CALCRL CNR1 KIT TACR1
3 integument MP:0010771 9.7 ACADS CALCRL CNR1 KIT TACR1 TRPV1
4 liver/biliary system MP:0005370 9.35 ACADS BRD2 KIT TRPV1 UCHL1
5 renal/urinary system MP:0005367 9.02 ACADS BRD2 KIT TRPV1 UCHL1

Drugs & Therapeutics for Diverticulitis of Colon

Drugs for Diverticulitis of Colon (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
2
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
3
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
4
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
5
Orphenadrine Approved Phase 4 83-98-7 4601
6
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
7
Morphine Approved, Investigational Phase 4 57-27-2 5288826
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
9
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
10
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
11
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
12
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
13
Acetaminophen Approved Phase 4 103-90-2 1983
14
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
15
Methadone Approved Phase 4 76-99-3 4095
16 Antipyretics Phase 4
17 Antitussive Agents Phase 4
18 Anti-Inflammatory Agents, Non-Steroidal Phase 4
19 Adjuvants, Anesthesia Phase 4
20 Anti-Arrhythmia Agents Phase 4
21 Anesthetics, Dissociative Phase 4
22 Cytochrome P-450 Enzyme Inhibitors Phase 4
23 Ketorolac Tromethamine Phase 4
24 Autonomic Agents Phase 4
25 Cholinergic Antagonists Phase 4
26 Anti-Anxiety Agents Phase 4
27 Analgesics Phase 4
28 Excitatory Amino Acids Phase 4
29 calcium channel blockers Phase 4
30 Anesthetics, Local Phase 4
31 Parasympatholytics Phase 4
32 Cyclooxygenase Inhibitors Phase 4
33 Antiparkinson Agents Phase 4
34 Anesthetics Phase 4
35 Antirheumatic Agents Phase 4
36 Acetaminophen, hydrocodone drug combination Phase 4
37 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
38 Excitatory Amino Acid Antagonists Phase 4
39 Diuretics, Potassium Sparing Phase 4
40 Anti-Inflammatory Agents Phase 4
41 Anesthetics, Intravenous Phase 4
42 Central Nervous System Depressants Phase 4
43 Sodium Channel Blockers Phase 4
44 Narcotics Phase 4
45 Tranquilizing Agents Phase 4
46 Calcium, Dietary Phase 4
47 Neuromuscular Agents Phase 4
48 Neurotransmitter Agents Phase 4
49 Cholinergic Agents Phase 4
50 Analgesics, Opioid Phase 4

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery Recruiting NCT02958566 Phase 4 Acetaminophen;Gabapentin;Orphenadrine;Lidocaine;Marcaine;Ketamine;Methadone;Tramadol;Ketorolac;Morphine Sulfate;Fentanyl;Dilaudid;Hydrocodone-Acetaminophen Tab 5-325 MG;Morphine Sulfate;Fentanyl;Dilaudid;HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET
2 Hartmann vs R/A in Peritonitis by Perforated Diverticulitis Completed NCT01239927 Phase 2, Phase 3
3 Antibiotic Therapy of Acute Uncomplicated Colonic Diverticulitis Completed NCT01008488 Not Applicable Antibiotic
4 The Out-patient, Non Antibiotic Management of Patients With Acute Uncomplicated Colonic Diverticulitis Completed NCT01515150
5 Occult Obscure Gastrointestinal Bleeding Completed NCT03464539 Not Applicable
6 Diagnostic Accuracy of Bedside Ultrasound in Suspected Acute Diverticulitis Completed NCT03279588
7 Primary vs. Secondary Anastomosis for Hinchey Stage III-IV Diverticulitis a Prospective Randomized Trial Completed NCT00692393 Not Applicable
8 Colonic Resections in Patients With Suspected Appendicitis Completed NCT00888888
9 Prevalence of Colon Cancer in Pyogenic Liver Abscess Completed NCT02032914
10 Laparoscopic-lavage Observational Study Recruiting NCT02662088
11 Laparoscopic Peritoneal Lavage vs Laparoscopic Sigmoidectomy in Perforated Acute Diverticulitis: a Multicenter Prospective Observational Study (STELLA Study) Recruiting NCT03008707
12 Seal-G MIST (Minimally Invasive Sealant/Spray Technology) System Safety Study [SEALAR Study] Not yet recruiting NCT03448874 Not Applicable
13 Intraoperative Testing of Colorectal Anastomosis - Air or Water (Methylene Blue)? Not yet recruiting NCT03316677 Not Applicable

Search NIH Clinical Center for Diverticulitis of Colon

Cochrane evidence based reviews: diverticulitis, colonic

Genetic Tests for Diverticulitis of Colon

Anatomical Context for Diverticulitis of Colon

MalaCards organs/tissues related to Diverticulitis of Colon:

41
Colon, Bone

Publications for Diverticulitis of Colon

Articles related to Diverticulitis of Colon:

(show all 16)
# Title Authors Year
1
LONG-TERM RESULTS OF SURGICAL TREATMENT OF DIVERTICULAR DISEASE OF COLON. ( 30427159 )
2016
2
Experience of managing complicated diverticulitis of colon: a retrospective case series from South Asian country. ( 24864634 )
2014
3
Pathophysiological aspects of diverticular disease of colon and role of large bowel motility. ( 14562365 )
2003
4
Long-term treatment with mesalazine and rifaximin versus rifaximin alone for patients with recurrent attacks of acute diverticulitis of colon. ( 12236485 )
2002
5
Diverticular disease of colon; Indian variant. ( 1949209 )
1991
6
Unusual cases of perforated diverticulitis of colon. ( 2230705 )
1990
7
Dietary fibre and prevention of diverticular disease of colon: evidence from rats. ( 6146851 )
1984
8
Diverticular disease of colon in China. A 60-year retrospective study. ( 6437755 )
1984
9
Case profile: unique uroradiographic manifestation of diverticulitis of colon. ( 7112836 )
1982
10
Emergency resection in treatment of diverticular disease of colon complicated by peritonitis. ( 5666803 )
1968
11
GENERALIZED PERITONITIS COMPLICATING ACUTE DIVERTICULITIS OF COLON. ( 14236316 )
1965
12
Surgical management in complications of diverticulitis of colon. ( 13661559 )
1959
13
Incidence and type of bleeding in diverticular disease of colon; analysis of 131 cases. ( 13609907 )
1958
14
Surgical treatment of diverticulitis of colon. ( 13227745 )
1955
15
Diverticulitis of colon and new aspects of its treatment with report of five cases. ( 14393950 )
1955
16
Intestinovesical fistula Report of three cases resulting from diverticulitis of colon. ( 14817551 )
1951

Variations for Diverticulitis of Colon

Expression for Diverticulitis of Colon

Search GEO for disease gene expression data for Diverticulitis of Colon.

Pathways for Diverticulitis of Colon

GO Terms for Diverticulitis of Colon

Cellular components related to Diverticulitis of Colon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.1 CALCRL CD1A CNR1 KIT TACR1 TRPV1

Biological processes related to Diverticulitis of Colon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual learning GO:0008542 9.16 KIT NPS
2 response to pain GO:0048265 8.96 TACR1 TRPV1
3 sensory perception of pain GO:0019233 8.8 CNR1 TRPV1 UCHL1

Molecular functions related to Diverticulitis of Colon according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 8.8 CALCRL KIT TRPV1

Sources for Diverticulitis of Colon

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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