HS3
MCID: DNS008
MIFTS: 18

Dna, Satellite, Iii (HS3)

Aliases & Classifications for Dna, Satellite, Iii

MalaCards integrated aliases for Dna, Satellite, Iii:

Name: Dna, Satellite, Iii 58 56
Hs3 58

External Ids:

OMIM 58 126370

Summaries for Dna, Satellite, Iii

MalaCards based summary : Dna, Satellite, Iii, also known as hs3, is related to spherocytosis, type 3 and retinoblastoma. An important gene associated with Dna, Satellite, Iii is MYC (MYC Proto-Oncogene, BHLH Transcription Factor). The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include breast.

Description from OMIM: 126370

Related Diseases for Dna, Satellite, Iii

Diseases in the Dna, Satellite, Iii family:

Dna, Satellite, Alpha Type

Diseases related to Dna, Satellite, Iii via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 spherocytosis, type 3 11.4
2 retinoblastoma 10.2
3 thalassemia 10.2
4 burkitt lymphoma 10.1
5 beta-thalassemia 10.1

Graphical network of the top 20 diseases related to Dna, Satellite, Iii:



Diseases related to Dna, Satellite, Iii

Symptoms & Phenotypes for Dna, Satellite, Iii

Clinical features from OMIM:

126370

Drugs & Therapeutics for Dna, Satellite, Iii

Drugs for Dna, Satellite, Iii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2 1177-87-3
3
Racepinephrine Approved Phase 4,Phase 2 329-65-7 838
4
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
5 Autonomic Agents Phase 4,Phase 2
6 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
7 Adrenergic Agonists Phase 4,Phase 2
8 Bronchodilator Agents Phase 4,Phase 2
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
10 Sympathomimetics Phase 4,Phase 2
11 Epinephryl borate Phase 4,Phase 2
12 Adrenergic alpha-Agonists Phase 4,Phase 2
13 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
14 BB 1101 Phase 4,Phase 2
15 Hormone Antagonists Phase 4,Phase 2
16 Adrenergic Agents Phase 4,Phase 2
17 Gastrointestinal Agents Phase 4,Phase 2
18 Adrenergic beta-Agonists Phase 4,Phase 2
19 Neurotransmitter Agents Phase 4,Phase 2
20 HIV Protease Inhibitors Phase 4,Phase 2
21 glucocorticoids Phase 4,Phase 2
22 Antiemetics Phase 4,Phase 2
23 Antineoplastic Agents, Hormonal Phase 4,Phase 2
24 Hormones Phase 4,Phase 2
25 Respiratory System Agents Phase 4,Phase 2
26 Vasoconstrictor Agents Phase 4,Phase 2
27 Mydriatics Phase 4,Phase 2
28
protease inhibitors Phase 4,Phase 2
29 Anti-Asthmatic Agents Phase 4,Phase 2
30 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
31
Diclofenac Approved, Vet_approved Phase 3 15307-86-5 3033
32
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
33 Antirheumatic Agents Phase 3,Phase 2
34 Analgesics Phase 3,Phase 2
35 Central Nervous System Depressants Phase 3
36 Analgesics, Non-Narcotic Phase 3,Phase 2
37 Cyclooxygenase Inhibitors Phase 3
38 Anti-Arrhythmia Agents Phase 3
39 Anti-Inflammatory Agents, Non-Steroidal Phase 3,Phase 2
40 Anesthetics, Local Phase 3
41 Anesthetics Phase 3
42 Diuretics, Potassium Sparing Phase 3
43 Sodium Channel Blockers Phase 3
44
Benzocaine Approved, Investigational Phase 1, Phase 2 1994-09-7, 94-09-7 2337
45
tannic acid Approved Phase 1, Phase 2 1401-55-4
46
Curcumin Approved, Experimental, Investigational Phase 2 458-37-7 969516
47 Arginine Vasopressin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Epinephrine, Dexamethasone, and Hypertonic Saline in Bronchiolitis, Randomised Clinical Trial of Efficacy and Safety Completed NCT01834820 Phase 4 Epinephrine and Dexamethasone;Hypertonic Saline;Normal Saline
2 Diclofenac Potassium With Lidocaine Cream in Reducing Pain During HSG Completed NCT02709590 Phase 3 diclofenac potassium + lidocaine;placebo
3 Epinephrine, Dexamethasone and Hypertonic Saline in Bronchiolitis Unknown status NCT02585531 Phase 2 Hypertonic Saline 3%;Epinephrine and Dexamethasone
4 Safety and Feasibility of Hypertonic Saline Solution After Aneurysmal Subarachnoid Hemorrhage: Unknown status NCT02432157 Phase 1, Phase 2 HTS 3%;Standard fluid management
5 Micellar Curcumin and Metabolic Syndrome Biomarkers Completed NCT01925547 Phase 2
6 Influence of the Nebulizer on the Clinical Efficacy of Hypertonic Saline 3% in Children Aged Less Than 18 Months and Hospitalized With Acute Viral Bronchiolitis Unknown status NCT01295398 Not Applicable
7 High Sensitive Troponin T (hsTnT) and Copeptin as Prognostic Parameters in Patients With Elective Total Endoprosthesis Unknown status NCT01335815

Search NIH Clinical Center for Dna, Satellite, Iii

Genetic Tests for Dna, Satellite, Iii

Anatomical Context for Dna, Satellite, Iii

MalaCards organs/tissues related to Dna, Satellite, Iii:

42
Breast

Publications for Dna, Satellite, Iii

Articles related to Dna, Satellite, Iii:

(show all 27)
# Title Authors Year
1
O-Antigens of Escherichia coli Strains O81 and HS3-104 Are Structurally and Genetically Related, Except O-Antigen Glucosylation in E. coli HS3-104. ( 29738687 )
2018
2
Dust Impacts on the 2012 Hurricane Nadine Track during the NASA HS3 Field Campaign. ( 30344342 )
2018
3
Towards Polysulfuric Acids: The Hydrogentrisulfate Anion [HS3 O10 ]- in A[HS3 O10 ] (A=Na, K, Rb). ( 27529393 )
2016
4
Hb S/β+-thalassemia due to Hb sickle and a novel deletion of DNase I hypersensitive sites HS3 and HS4 of the β locus control region. ( 25682598 )
2015
5
The plastidic DEAD-box RNA helicase 22, HS3, is essential for plastid functions both in seed development and in seedling growth. ( 23803517 )
2013
6
Changing the conversation--the occupational health nurse's role in integrated HS3. ( 19639861 )
2009
7
Expression of green fluorescent protein under the regulation of human locus control region elements HS2 and HS3 in transgenic mice. ( 18512117 )
2008
8
Activation of the c-myc p1 promoter in Burkitt's lymphoma by the hs3 immunoglobulin heavy-chain gene enhancer. ( 17287852 )
2007
9
The polymorphism of the locus control region lying downstream the human IgH locus is restricted to hs1,2 but not to hs3 and hs4 enhancers. ( 15234538 )
2004
10
Locus control region elements HS2 and HS3 in combination with chromatin boundaries confer high-level expression of a human beta-globin transgene in a centromeric region. ( 15507116 )
2004
11
Beta-globin locus control region HS2 and HS3 interact structurally and functionally. ( 12582237 )
2003
12
Yin Yang 1 is a lipopolysaccharide-inducible activator of the murine 3' Igh enhancer, hs3. ( 12759432 )
2003
13
Effects of human locus control region elements HS2 and HS3 on human beta-globin gene expression in transgenic mouse. ( 14636653 )
2003
14
Functional and binding studies of HS3.2 of the beta-globin locus control region. ( 11867225 )
2002
15
Human satellite 3 (HS3) binding protein from the nuclear matrix: isolation and binding properties. ( 10903425 )
2000
16
The roles of 5'-HS2, 5'-HS3, and the gamma-globin TATA, CACCC, and stage selector elements in suppression of beta-globin expression in early development. ( 10196210 )
1999
17
Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletion. ( 9632803 )
1998
18
Dyad symmetry within the mouse 3' IgH regulatory region includes two virtually identical enhancers (C alpha3'E and hs3). ( 9144492 )
1997
19
Identification of a homolog of the C alpha 3'/hs3 enhancer and of an allelic variant of the 3'IgH/hs1,2 enhancer downstream of the human immunoglobulin alpha 1 gene. ( 9394827 )
1997
20
Partial repression of human gamma-globin genes by LCR element HS3 when linked to beta-globin genes and LCR element HS2 in MEL cells. ( 8619403 )
1996
21
Role of DNA sequences outside the cores of DNase hypersensitive sites (HSs) in functions of the beta-globin locus control region. Domain opening and synergism between HS2 and HS3. ( 8662652 )
1996
22
Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4. ( 8543153 )
1995
23
The position of integration affects expression of the A gamma-globin-encoding gene linked to HS3 in transgenic mice. ( 7642090 )
1995
24
Comparative analysis of the locus control region of the rabbit beta-like gene cluster: HS3 increases transient expression of an embryonic epsilon-globin gene. ( 8464710 )
1993
25
A modification of the HS3 thoracic Alpha Cradle for breast/chestwall patients. ( 2340083 )
1990
26
Recharacterization of fungal dinucleoside polyphosphate (HS3). ( 647443 )
1978
27
Possible regulation of macromolecular biosynthesis in mammalian cells by a novel dinucleoside polyphosphate (HS3) produced during step-down growth conditions. ( 591567 )
1977

Variations for Dna, Satellite, Iii

Expression for Dna, Satellite, Iii

Search GEO for disease gene expression data for Dna, Satellite, Iii.

Pathways for Dna, Satellite, Iii

GO Terms for Dna, Satellite, Iii

Sources for Dna, Satellite, Iii

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63 PubMed
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70 SNOMED-CT via HPO
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72 TGDB
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74 UMLS
75 UMLS via Orphanet
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