MCID: DBL004
MIFTS: 23

Double Discordia

Categories: Rare diseases

Aliases & Classifications for Double Discordia

MalaCards integrated aliases for Double Discordia:

Name: Double Discordia 53
Atrio-Ventricular and Ventriculo-Arterial Double Discordia 53
Corrected Transposition 53

Classifications:



Summaries for Double Discordia

MalaCards based summary : Double Discordia, also known as atrio-ventricular and ventriculo-arterial double discordia, is related to congenitally corrected transposition of the great arteries and transposition of the great arteries. The drugs Tadalafil and Phosphodiesterase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include heart, atrioventricular node and lung.

Wikipedia : 75 Transposition of the great vessels (TGV) is a group of congenital heart defects involving an abnormal... more...

Related Diseases for Double Discordia

Diseases related to Double Discordia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 congenitally corrected transposition of the great arteries 13.0
2 transposition of the great arteries 11.2
3 heart septal defect 10.9
4 ventricular septal defect 10.9
5 tricuspid valve insufficiency 10.6
6 situs inversus 10.6
7 atrioventricular block 10.6
8 dextrocardia 10.6
9 atrial heart septal defect 10.5
10 congestive heart failure 10.4
11 mitral valve insufficiency 10.3
12 single ventricular heart 10.3
13 pulmonic stenosis 10.3
14 cyanosis, transient neonatal 10.3
15 levocardia 10.3
16 pulmonary valve stenosis 10.2
17 dextrocardia with situs inversus 10.2
18 aortic valve insufficiency 10.2
19 aortic coarctation 10.2
20 pulmonary hypertension 10.2
21 cardiac arrest 10.2
22 double outlet right ventricle 10.2
23 endocarditis 10.2
24 mesocardia 10.2
25 coronary artery anomaly 10.1
26 subpulmonary stenosis 10.1
27 patent ductus arteriosus 1 10.1
28 syncope 10.1
29 ebstein anomaly 10.1
30 cor triatriatum 10.1
31 isolated levocardia 10.1
32 aortic valve disease 1 10.0
33 pulmonary edema 10.0
34 patent foramen ovale 10.0
35 univentricular heart 10.0
36 progressive familial heart block, type ia 10.0
37 tetralogy of fallot 10.0
38 wolff-parkinson-white syndrome 10.0
39 ventricular fibrillation, paroxysmal familial, 1 10.0
40 sinoatrial node disease 10.0
41 left bundle branch hemiblock 10.0
42 sick sinus syndrome 10.0
43 ischemia 10.0
44 tricuspid valve stenosis 10.0
45 aortic arch interruption 10.0
46 aneurysm 10.0
47 arteries, anomalies of 9.9
48 pulmonary hypertension, primary, 1 9.9
49 heart block, congenital 9.9
50 atrioventricular septal defect 9.9

Graphical network of the top 20 diseases related to Double Discordia:



Diseases related to Double Discordia

Symptoms & Phenotypes for Double Discordia

Drugs & Therapeutics for Double Discordia

Drugs for Double Discordia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tadalafil Approved, Investigational Phase 3 171596-29-5 110635
2 Phosphodiesterase Inhibitors Phase 3
3 Phosphodiesterase 5 Inhibitors Phase 3
4 Vasodilator Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Phosphodiesterase-5 Inhibition With Tadalafil on SystEmic Right VEntricular Size and Function - a Multi-center, Double-blind, Randomized, Placebo-controlled Clinical Trial - SERVE Trial Active, not recruiting NCT03049540 Phase 3 Tadalafil 20 MG;Placebo 20 MG
2 Study of Adaptation of the Right Ventricle to Systemic Afterload Completed NCT02066506
3 Pacemaker Therapy in Adults With Congenital Heart Defects Completed NCT00303511
4 Computer Modeling of Congenital Heart Disease Completed NCT00366847
5 Follow up of Adults With Congenitally Malformed Hearts With Focus on Computer-Based Education and Psychosocial Support Completed NCT01234753
6 Sudden Cardiac Death in Congenital Heart Diseases With a Systemic Right Ventricle Recruiting NCT03833843

Search NIH Clinical Center for Double Discordia

Genetic Tests for Double Discordia

Anatomical Context for Double Discordia

MalaCards organs/tissues related to Double Discordia:

41
Heart, Atrioventricular Node, Lung, Testes, Brain, Bone, Bone Marrow

Publications for Double Discordia

Articles related to Double Discordia:

(show top 50) (show all 1311)
# Title Authors PMID Year
1
Exploring the Prognostic Value of Novel Markers in Adults With a Systemic Right Ventricle. 38
31431113 2019
2
Ventricular assist device implantation in patients with a failing systemic right ventricle: a call to expand current practice. 38
31420818 2019
3
Successful staged tricuspid valve replacement following cardiac resynchronization therapy in a congenitally corrected transposition of the great arteries. 38
31428373 2019
4
Congenitally corrected transposition of the great arteries in a 69-year-old woman. 38
31302072 2019
5
Postoperative and short-term atrial tachyarrhythmia burdens after transcatheter vs surgical pulmonary valve replacement among congenital heart disease patients. 38
31282099 2019
6
Hemodynamically balanced congenitally corrected transposition of the great arteries with a large ventricular septal defect, and subvalvular pulmonic stenosis: a case report. 38
31319891 2019
7
The impact of pulmonary artery banding and cardiac resynchronization therapy for the adult patient with congenitally corrected transposition of the great arteries. 38
31286415 2019
8
Successful ablation for premature ventricular contraction originating from moderator band of morphologic right ventricle in congenitally corrected transposition of great arteries. 38
31376744 2019
9
Virtual dissection and endocast three-dimensional reconstructions: maximizing computed tomographic data for procedural planning of an obstructed pulmonary venous baffle. 38
31347481 2019
10
Ventricular assist device in a patient with congenitally corrected transposition of the great arteries and situs inversus totalis. 38
30630389 2019
11
3D Printing to Model Surgical Repair of Complex Congenitally Corrected Transposition of the Great Arteries. 38
28825385 2019
12
Congenitally corrected transposition of the great vessels: evaluation with cardiac magnetic resonance imaging after double-switch repair. 38
30527267 2019
13
Catheter ablation of supraventricular tachycardia in patients with dextrocardia and situs inversus. 38
30661266 2019
14
Pulmonary Artery Banding for Congenitally Corrected Transposition of the Great Arteries With Hydrops Fetalis: A Case Report. 38
31018764 2019
15
Medical Therapy for Systemic Right Ventricles: A Systematic Review (Part 1) for the 2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. 38
30586770 2019
16
Medical Therapy for Systemic Right Ventricles: A Systematic Review (Part 1) for the 2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. 38
30121238 2019
17
Surgical Outcomes of Anatomical Repair for Congenitally Corrected Transposed Great Arteries. 38
31085133 2019
18
Fate of the Left Ventricular Outflow Tract After Rastelli With Selective Infundibular Muscle Resection. 38
30529669 2019
19
[Congenitally Corrected Transposition of the Great Arteries( TGA) in Adult]. 38
31266912 2019
20
Tricuspid Valve Imaging and Intervention in Pediatric and Adult Patients With Congenital Heart Disease. 38
30947906 2019
21
[Valve Replacement for Tricuspid Regurgitation with Congenitally Corrected Transposition of the Great Arteries]. 38
30923295 2019
22
Successful Left Ventricular Lead Placement in Congenitally Corrected Transposition of the Great Arteries and Situs Inversus. 38
30898247 2019
23
Long-term clinical outcomes of valsartan in patients with a systemic right ventricle: Follow-up of a multicenter randomized controlled trial. 38
30449692 2019
24
Clinical Evaluation of Exercise Capacity in Adults with Systemic Right Ventricle. 38
30833832 2019
25
Does Echocardiography Have a Role in the Cardiologist's Diagnosis of Innocent Murmurs in Childhood? 38
30876810 2019
26
Management of the Adult Patient With Congenitally Corrected Transposition: Challenges and Uncertainties. 38
31027566 2019
27
Mechanical Support for Patients With Congenitally Corrected Transposition of the Great Arteries and End-Stage Ventricular Dysfunction. 38
31027567 2019
28
Congenitally Corrected Transposition of the Great Arteries: Anatomic, Physiologic Repair, and Palliation. 38
31027562 2019
29
Bridge to Transplantation With Long-Term Mechanical Assist Devices in Adults With Transposition of the Great Arteries. 38
30129258 2019
30
Congenitally Corrected Transposition Presenting in the First Year of Life: Survival and Fate of the Systemic Right Ventricle. 38
30760124 2019
31
Corrected Transposition: Anatomic Repair Using the Hemi-Mustard Atrial Baffle and Bidirectional Superior Cavopulmonary Connection. 38
31027564 2019
32
Anatomic Repair of Corrected Transposition of the Great Arteries: The Double Switch. 38
31027565 2019
33
Left Ventricular Re-training: Feasibility and Effectiveness-What Are the Limits? 38
31027563 2019
34
Cardiac resynchronization therapy in congenital heart disease: Results from the German National Register for Congenital Heart Defects. 38
30297188 2018
35
Implantation techniques and outcomes after cardiac resynchronization therapy for congenitally corrected transposition of the great arteries. 38
30125719 2018
36
Utility of a super-flexible three-dimensional printed heart model in congenital heart surgery. 38
29846596 2018
37
Ventricular arrhythmia burden after transcatheter versus surgical pulmonary valve replacement. 38
29636402 2018
38
Making complex pathology simple: added value of 3D transthoracic echocardiography in an adult patient with congenitally corrected transposition of great arteries and severe tricuspid regurgitation. 38
30016399 2018
39
Cryoablation for Perinodal Arrhythmia Substrates in Patients With Congenital Heart Disease and Displaced Atrioventricular Conduction Systems. 38
30336879 2018
40
A Rare Combination of Congenitally Corrected Transposition of the Great Arteries with Pulmonary Artery Aneurysm. 38
30370391 2018
41
High-Sensitive Cardiac Troponin T and Systemic Right Ventricular Area Predict Outcomes in Adults With Congenitally Corrected Transposition. 38
30170667 2018
42
Outcomes of the anatomical repair in patients with congenitally corrected transposition of the great arteries: lessons learned in a high-volume centre. 38
29566142 2018
43
Inter- and intra-ventricular dyssynchrony in the systemic right ventricle is a surrogate marker of major cardiac events in mildly symptomatic patients. 38
29492650 2018
44
Live-Born Major Congenital Heart Disease in Denmark: Incidence, Detection Rate, and Termination of Pregnancy Rate From 1996 to 2013. 38
30027209 2018
45
Late recovery of sinus rhythm following perioperative complete atrioventricular block in a child with congenitally corrected transposition. 38
30271020 2018
46
Continuous-Flow Left Ventricular Assist Device Therapy in Adults with Transposition of the Great Vessels. 38
30101823 2018
47
Unusual association between corrected transposition of great arteries and supracardiac total anomalous pulmonary venous connection: a rare combination never reported before. 38
29972112 2018
48
Response to: 'Contemporary management and outcomes in congenitally corrected transposition of the great arteries' by Kutty et al. 38
29945948 2018
49
Contemporary management and outcomes in congenitally corrected transposition of the great arteries. 38
29326110 2018
50
Anatomy of the ventricular septal defect in congenital heart defects: a random association? 38
30021599 2018

Variations for Double Discordia

Expression for Double Discordia

Search GEO for disease gene expression data for Double Discordia.

Pathways for Double Discordia

GO Terms for Double Discordia

Sources for Double Discordia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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