MCID: DBL004
MIFTS: 23

Double Discordia

Categories: Rare diseases

Aliases & Classifications for Double Discordia

MalaCards integrated aliases for Double Discordia:

Name: Double Discordia 52
Atrio-Ventricular and Ventriculo-Arterial Double Discordia 52
Corrected Transposition 52

Classifications:



Summaries for Double Discordia

MalaCards based summary : Double Discordia, also known as atrio-ventricular and ventriculo-arterial double discordia, is related to congenitally corrected transposition of the great arteries and dextro-looped transposition of the great arteries. The drugs Tadalafil and Vasodilator Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and bone.

Wikipedia : 74 Transposition of the great vessels (TGV) is a group of congenital heart defects involving an abnormal... more...

Related Diseases for Double Discordia

Diseases related to Double Discordia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 congenitally corrected transposition of the great arteries 13.0
2 dextro-looped transposition of the great arteries 11.1
3 heart septal defect 10.9
4 ventricular septal defect 10.9
5 tricuspid valve insufficiency 10.6
6 situs inversus 10.6
7 atrioventricular block 10.6
8 dextrocardia 10.6
9 atrial heart septal defect 10.5
10 congestive heart failure 10.4
11 mitral valve insufficiency 10.3
12 single ventricular heart 10.3
13 pulmonic stenosis 10.3
14 cyanosis, transient neonatal 10.3
15 dextrocardia with situs inversus 10.3
16 levocardia 10.3
17 pulmonary valve stenosis 10.2
18 aortic valve insufficiency 10.2
19 pulmonary hypertension 10.2
20 double outlet right ventricle 10.2
21 mesocardia 10.2
22 cardiac arrest 10.2
23 endocarditis 10.1
24 coronary artery anomaly 10.1
25 subpulmonary stenosis 10.1
26 coarctation of aorta 10.1
27 patent ductus arteriosus 1 10.1
28 syncope 10.1
29 ebstein anomaly 10.1
30 cor triatriatum 10.1
31 isolated levocardia 10.1
32 aortic valve disease 1 10.0
33 pulmonary edema 10.0
34 patent foramen ovale 10.0
35 univentricular heart 10.0
36 progressive familial heart block, type ia 10.0
37 tetralogy of fallot 10.0
38 wolff-parkinson-white syndrome 10.0
39 ventricular fibrillation, paroxysmal familial, 1 10.0
40 sinoatrial node disease 10.0
41 infective endocarditis 10.0
42 left bundle branch hemiblock 10.0
43 heart disease 10.0
44 sick sinus syndrome 10.0
45 ischemia 10.0
46 tricuspid valve stenosis 10.0
47 aortic arch interruption 10.0
48 aneurysm 10.0
49 arteries, anomalies of 9.9
50 pulmonary hypertension, primary, 1 9.9

Graphical network of the top 20 diseases related to Double Discordia:



Diseases related to Double Discordia

Symptoms & Phenotypes for Double Discordia

Drugs & Therapeutics for Double Discordia

Drugs for Double Discordia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tadalafil Approved, Investigational Phase 3 171596-29-5 110635
2 Vasodilator Agents Phase 3
3 Phosphodiesterase 5 Inhibitors Phase 3
4 Phosphodiesterase Inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Phosphodiesterase-5 Inhibition With Tadalafil on SystEmic Right VEntricular Size and Function - a Multi-center, Double-blind, Randomized, Placebo-controlled Clinical Trial - SERVE Trial Active, not recruiting NCT03049540 Phase 3 Tadalafil 20 MG;Placebo 20 MG
2 Study of Adaptation of the Right Ventricle to Systemic Afterload Completed NCT02066506
3 Pacemaker Therapy in Adults With Congenital Heart Defects Completed NCT00303511
4 Computer Modeling of Congenital Heart Disease Completed NCT00366847
5 Follow up of Adults With Congenitally Malformed Hearts With Focus on Computer-Based Education and Psychosocial Support Completed NCT01234753
6 Sudden Cardiac Death in Congenital Heart Diseases With a Systemic Right Ventricle Recruiting NCT03833843
7 Evaluation Of Performance & Complications of Pacemakers in Children Not yet recruiting NCT04163770

Search NIH Clinical Center for Double Discordia

Genetic Tests for Double Discordia

Anatomical Context for Double Discordia

MalaCards organs/tissues related to Double Discordia:

40
Heart, Lung, Bone, Atrioventricular Node, Testes, Brain, Bone Marrow

Publications for Double Discordia

Articles related to Double Discordia:

(show top 50) (show all 1330)
# Title Authors PMID Year
1
Does Echocardiography Have a Role in the Cardiologist's Diagnosis of Innocent Murmurs in Childhood? 61
30876810 2020
2
The Cardiac Genome Clinic: implementing genome sequencing in pediatric heart disease. 61
32037394 2020
3
Congenitally corrected transposition of the great arteries: is it really a transposition? An anatomical study of the right ventricular septal surface. 61
31657020 2020
4
A unique indication for the senning procedure: Atrioventricular discordance with ventriculoarterial concordance. 61
31793037 2020
5
Global longitudinal strain correlates to systemic right ventricular function. 61
31987049 2020
6
A Rare Case of Congenital Heart Disease- Congenitally Corrected Transposition of Great Arteries (CC-TGA) with Infective Endocarditis and Stroke. 61
31979603 2020
7
Prenatal Diagnosis and Outcome of Congenital Corrected Transposition of the Great Arteries - A Multicenter Report of 69 Cases. 61
31995816 2020
8
Three-dimensional mapping-guided permanent His bundle pacing in a patient with corrected transposition of great arteries. 61
31890586 2019
9
In congenitally corrected transposition of great arteries following Fontan surgery, a left ventricle with suprasystemic systolic and high end-diastolic pressures paradoxically preserves right ventricular and tricuspid valve function. 61
31666144 2019
10
Prenatal diagnosis of congenitally corrected transposition of the great arteries. 61
32021715 2019
11
EDUCATIONAL SERIES IN CONGENITAL HEART DISEASE: Echocardiographic assessment of transposition of the great arteries and congenitally corrected transposition of the great arteries 61
31729212 2019
12
Systematic Evaluation of Systemic Right Ventricular Function. 61
31906129 2019
13
Mechanisms for heart failure in systemic right ventricle. 61
31853794 2019
14
Ventricular assist device implantation in patients with a failing systemic right ventricle: a call to expand current practice. 61
31420818 2019
15
Commentary: No pain no gain-what is the best retraining pathway for patients with corrected transposition? 61
31839229 2019
16
Left ventricular retraining in corrected transposition: Relationship between pressure and mass. 61
31761342 2019
17
A Case of Transposition of Great Arteries with Ventricular Septal Defect and Mesocardia Presenting for Neurosurgery. 61
31831995 2019
18
Successful ablation for premature ventricular contraction originating from moderator band of morphologic right ventricle in congenitally corrected transposition of great arteries. 61
31376744 2019
19
Postoperative and short-term atrial tachyarrhythmia burdens after transcatheter vs surgical pulmonary valve replacement among congenital heart disease patients. 61
31282099 2019
20
A de novo splicing variant supports the candidacy of TLL1 in ASD pathogenesis. 61
31570783 2019
21
Exploring the Prognostic Value of Novel Markers in Adults With a Systemic Right Ventricle. 61
31431113 2019
22
A case of 15-year misdiagnosed heart failure: congenitally corrected transposition of the great arteries. 61
31660510 2019
23
Virtual dissection and endocast three-dimensional reconstructions: maximizing computed tomographic data for procedural planning of an obstructed pulmonary venous baffle. 61
31347481 2019
24
Acute Appendicitis in a Patient with Situs Inversus Totalis, Intestinal Malrotation, and Congenitally Corrected Transposition of the Great Arteries. 61
31560326 2019
25
Successful staged tricuspid valve replacement following cardiac resynchronization therapy in a congenitally corrected transposition of the great arteries. 61
31428373 2019
26
L-looped Transposition of the Great Arteries in a Patient with Marfanoid Habitus: First Reported Case in Literature. 61
31632869 2019
27
Hemodynamically balanced congenitally corrected transposition of the great arteries with a large ventricular septal defect, and subvalvular pulmonic stenosis: a case report. 61
31319891 2019
28
Congenitally corrected transposition of the great arteries in a 69-year-old woman. 61
31302072 2019
29
The impact of pulmonary artery banding and cardiac resynchronization therapy for the adult patient with congenitally corrected transposition of the great arteries. 61
31286415 2019
30
Ventricular assist device in a patient with congenitally corrected transposition of the great arteries and situs inversus totalis. 61
30630389 2019
31
Congenitally corrected transposition of the great vessels: evaluation with cardiac magnetic resonance imaging after double-switch repair. 61
30527267 2019
32
3D Printing to Model Surgical Repair of Complex Congenitally Corrected Transposition of the Great Arteries. 61
28825385 2019
33
Surgical Outcomes of Anatomical Repair for Congenitally Corrected Transposed Great Arteries. 61
31085133 2019
34
Catheter ablation of supraventricular tachycardia in patients with dextrocardia and situs inversus. 61
30661266 2019
35
[Congenitally Corrected Transposition of the Great Arteries( TGA) in Adult]. 61
31266912 2019
36
Tricuspid Valve Imaging and Intervention in Pediatric and Adult Patients With Congenital Heart Disease. 61
30947906 2019
37
Pulmonary Artery Banding for Congenitally Corrected Transposition of the Great Arteries With Hydrops Fetalis: A Case Report. 61
31018764 2019
38
Medical Therapy for Systemic Right Ventricles: A Systematic Review (Part 1) for the 2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. 61
30586770 2019
39
Medical Therapy for Systemic Right Ventricles: A Systematic Review (Part 1) for the 2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. 61
30121238 2019
40
Fate of the Left Ventricular Outflow Tract After Rastelli With Selective Infundibular Muscle Resection. 61
30529669 2019
41
Long-term clinical outcomes of valsartan in patients with a systemic right ventricle: Follow-up of a multicenter randomized controlled trial. 61
30449692 2019
42
[Valve Replacement for Tricuspid Regurgitation with Congenitally Corrected Transposition of the Great Arteries]. 61
30923295 2019
43
Successful Left Ventricular Lead Placement in Congenitally Corrected Transposition of the Great Arteries and Situs Inversus. 61
30898247 2019
44
Clinical Evaluation of Exercise Capacity in Adults with Systemic Right Ventricle. 61
30833832 2019
45
Corrected Transposition: Anatomic Repair Using the Hemi-Mustard Atrial Baffle and Bidirectional Superior Cavopulmonary Connection. 61
31027564 2019
46
Left Ventricular Re-training: Feasibility and Effectiveness-What Are the Limits? 61
31027563 2019
47
Congenitally Corrected Transposition Presenting in the First Year of Life: Survival and Fate of the Systemic Right Ventricle. 61
30760124 2019
48
Congenitally Corrected Transposition of the Great Arteries: Anatomic, Physiologic Repair, and Palliation. 61
31027562 2019
49
Anatomic Repair of Corrected Transposition of the Great Arteries: The Double Switch. 61
31027565 2019
50
Bridge to Transplantation With Long-Term Mechanical Assist Devices in Adults With Transposition of the Great Arteries. 61
30129258 2019

Variations for Double Discordia

Expression for Double Discordia

Search GEO for disease gene expression data for Double Discordia.

Pathways for Double Discordia

GO Terms for Double Discordia

Sources for Double Discordia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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