MCID: DBL004
MIFTS: 23

Double Discordia

Categories: Rare diseases

Aliases & Classifications for Double Discordia

MalaCards integrated aliases for Double Discordia:

Name: Double Discordia 52
Atrio-Ventricular and Ventriculo-Arterial Double Discordia 52
Corrected Transposition 52

Classifications:



Summaries for Double Discordia

MalaCards based summary : Double Discordia, also known as atrio-ventricular and ventriculo-arterial double discordia, is related to congenitally corrected transposition of the great arteries and dextro-looped transposition of the great arteries. The drugs Tadalafil and Phosphodiesterase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include heart, atrioventricular node and lung.

Wikipedia : 74 Transposition of the great vessels (TGV) is a group of congenital heart defects involving an abnormal... more...

Related Diseases for Double Discordia

Diseases related to Double Discordia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 congenitally corrected transposition of the great arteries 13.0
2 dextro-looped transposition of the great arteries 11.1
3 heart septal defect 10.9
4 ventricular septal defect 10.9
5 tricuspid valve insufficiency 10.6
6 situs inversus 10.6
7 atrioventricular block 10.6
8 dextrocardia 10.6
9 atrial heart septal defect 10.5
10 congestive heart failure 10.4
11 mitral valve insufficiency 10.3
12 single ventricular heart 10.3
13 cyanosis, transient neonatal 10.3
14 pulmonic stenosis 10.3
15 pulmonary valve stenosis 10.3
16 dextrocardia with situs inversus 10.3
17 levocardia 10.3
18 aortic valve insufficiency 10.2
19 pulmonary hypertension 10.2
20 double outlet right ventricle 10.2
21 mesocardia 10.2
22 cardiac arrest 10.2
23 endocarditis 10.2
24 subpulmonary stenosis 10.1
25 syncope 10.1
26 coarctation of aorta 10.1
27 patent ductus arteriosus 1 10.1
28 infective endocarditis 10.1
29 ebstein anomaly 10.1
30 cor triatriatum 10.1
31 isolated levocardia 10.1
32 aortic valve disease 1 10.0
33 ventricular fibrillation, paroxysmal familial, 1 10.0
34 pulmonary edema 10.0
35 patent foramen ovale 10.0
36 univentricular heart 10.0
37 arteries, anomalies of 10.0
38 progressive familial heart block, type ia 10.0
39 tetralogy of fallot 10.0
40 wolff-parkinson-white syndrome 10.0
41 hyperlipoproteinemia, type iii 10.0
42 lipoprotein quantitative trait locus 10.0
43 sinoatrial node disease 10.0
44 left bundle branch hemiblock 10.0
45 sick sinus syndrome 10.0
46 ischemia 10.0
47 tricuspid valve stenosis 10.0
48 aortic arch interruption 10.0
49 aneurysm 10.0
50 pulmonary hypertension, primary, 1 9.9

Graphical network of the top 20 diseases related to Double Discordia:



Diseases related to Double Discordia

Symptoms & Phenotypes for Double Discordia

Drugs & Therapeutics for Double Discordia

Drugs for Double Discordia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tadalafil Approved, Investigational Phase 3 171596-29-5 110635
2 Phosphodiesterase Inhibitors Phase 3
3 Phosphodiesterase 5 Inhibitors Phase 3
4 Vasodilator Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Phosphodiesterase-5 Inhibition With Tadalafil on SystEmic Right VEntricular Size and Function - a Multi-center, Double-blind, Randomized, Placebo-controlled Clinical Trial - SERVE Trial Active, not recruiting NCT03049540 Phase 3 Tadalafil 20 MG;Placebo 20 MG
2 Study of Adaptation of the Right Ventricle to Systemic Afterload Completed NCT02066506
3 Pacemaker Therapy in Adults With Congenital Heart Defects Completed NCT00303511
4 Computer Modeling of Congenital Heart Disease Completed NCT00366847
5 Follow up of Adults With Congenitally Malformed Hearts With Focus on Computer-Based Education and Psychosocial Support Completed NCT01234753
6 Sudden Cardiac Death in Congenital Heart Diseases With a Systemic Right Ventricle Recruiting NCT03833843
7 Evaluation Of Performance & Complications of Pacemakers in Children Not yet recruiting NCT04163770

Search NIH Clinical Center for Double Discordia

Genetic Tests for Double Discordia

Anatomical Context for Double Discordia

MalaCards organs/tissues related to Double Discordia:

40
Heart, Atrioventricular Node, Lung, Testes, Brain, Bone Marrow, Bone

Publications for Double Discordia

Articles related to Double Discordia:

(show top 50) (show all 1348)
# Title Authors PMID Year
1
Serial changes of tricuspid regurgitation after anatomic repair for congenitally corrected transposition. 61
32048707 2020
2
Mechanisms for heart failure in systemic right ventricle. 61
31853794 2020
3
Commentary: No pain no gain-what is the best retraining pathway for patients with corrected transposition? 61
31839229 2020
4
The Cardiac Genome Clinic: implementing genome sequencing in pediatric heart disease. 61
32037394 2020
5
Left ventricular retraining in corrected transposition: Relationship between pressure and mass. 61
31761342 2020
6
Surgical Outcomes of Anatomical Repair for Congenitally Corrected Transposed Great Arteries. 61
31085133 2020
7
Radiofrequency ablation for the pre-excitation syndrome of functionally corrected transposition of great arteries. 61
32176362 2020
8
Adverse impact of univentricular pacing for the patient with functional single ventricle: successful conversion to cardiac resynchronization therapy. 61
32405970 2020
9
The Author's Contributions to Echocardiography Literature (Part II-1991-2020). 61
32294978 2020
10
Incidental congenitally corrected transposition of the great arteries (ccTGA) in an adult with suspected coronary artery disease: review on radiological features and pathophysiology. 61
32327461 2020
11
Implantable cardiac electronic device therapy for patients with a systemic right ventricle. 61
32269130 2020
12
A de novo splicing variant supports the candidacy of TLL1 in ASD pathogenesis. 61
31570783 2020
13
Atrial tachycardia eliminated at the ventricular side in patients with congenitally corrected transposition of the great arteries: Electrophysiological findings and anatomical concerns. 61
32201269 2020
14
Permanent conduction system pacing for congenitally corrected transposition of the great arteries: A Pediatric and Congenital Electrophysiology Society (PACES)/International Society for Adult Congenital Heart Disease (ISACHD) Collaborative Study. 61
32243875 2020
15
IgA Vasculitis Triggered by Infective Endocarditis of Pulmonary Artery with Congenitally Corrected Transposition of the Great Arteries. 61
32173704 2020
16
Congenitally corrected transposition of the great arteries. 61
32274202 2020
17
Congenitally corrected transposition of the great arteries in a 69-year-old woman. 61
31302072 2020
18
Effectiveness of Bidirectional Glenn Shunt Placement for Palliation in Complex Congenitally Corrected Transposed Great Arteries. 61
32148447 2020
19
Does Echocardiography Have a Role in the Cardiologist's Diagnosis of Innocent Murmurs in Childhood? 61
30876810 2020
20
Congenitally corrected transposition of the great arteries, coronary anomaly and transplant. 61
32107147 2020
21
Permanent Conduction System Pacing for Congenitally Corrected Transposition of the Great Arteries. 61
32244058 2020
22
Late Presentation of a Congenitally Corrected Transposition of Great Arteries and Hemodynamically Balanced Ventricles Associated with a Large Ventricular Septal Defect and Severe Pulmonary Stenosis: A Case Report and a Multi-Imaging Approach. 61
32111814 2020
23
Congenitally corrected transposition of the great arteries: is it really a transposition? An anatomical study of the right ventricular septal surface. 61
31657020 2020
24
A unique indication for the senning procedure: Atrioventricular discordance with ventriculoarterial concordance. 61
31793037 2020
25
Global longitudinal strain correlates to systemic right ventricular function. 61
31987049 2020
26
Urgent double switch operation in a patient with congenitally corrected transposition of great arteries and an untrained systemic ventricle. 61
32175162 2020
27
Monitored Anesthesia Care of Two Patients with Highly Elevated Subpulmonic Ventricular Pressure due to Adult Congenital Heart Disease. 61
32395353 2020
28
A Rare Case of Congenital Heart Disease- Congenitally Corrected Transposition of Great Arteries (CC-TGA) with Infective Endocarditis and Stroke. 61
31979603 2020
29
Prenatal Diagnosis and Outcome of Congenital Corrected Transposition of the Great Arteries - A Multicenter Report of 69 Cases. 61
31995816 2020
30
Three-dimensional mapping-guided permanent His bundle pacing in a patient with corrected transposition of great arteries. 61
31890586 2019
31
In congenitally corrected transposition of great arteries following Fontan surgery, a left ventricle with suprasystemic systolic and high end-diastolic pressures paradoxically preserves right ventricular and tricuspid valve function. 61
31666144 2019
32
Prenatal diagnosis of congenitally corrected transposition of the great arteries. 61
32021715 2019
33
EDUCATIONAL SERIES IN CONGENITAL HEART DISEASE: Echocardiographic assessment of transposition of the great arteries and congenitally corrected transposition of the great arteries 61
31729212 2019
34
Ventricular fibrillation in congenitally corrected transposition of great arteries treated with pacing: a case report. 61
32123788 2019
35
Systematic Evaluation of Systemic Right Ventricular Function. 61
31906129 2019
36
Ventricular assist device implantation in patients with a failing systemic right ventricle: a call to expand current practice. 61
31420818 2019
37
A Case of Transposition of Great Arteries with Ventricular Septal Defect and Mesocardia Presenting for Neurosurgery. 61
31831995 2019
38
Successful ablation for premature ventricular contraction originating from moderator band of morphologic right ventricle in congenitally corrected transposition of great arteries. 61
31376744 2019
39
Exploring the Prognostic Value of Novel Markers in Adults With a Systemic Right Ventricle. 61
31431113 2019
40
Postoperative and short-term atrial tachyarrhythmia burdens after transcatheter vs surgical pulmonary valve replacement among congenital heart disease patients. 61
31282099 2019
41
A case of 15-year misdiagnosed heart failure: congenitally corrected transposition of the great arteries. 61
31660510 2019
42
Virtual dissection and endocast three-dimensional reconstructions: maximizing computed tomographic data for procedural planning of an obstructed pulmonary venous baffle. 61
31347481 2019
43
Successful staged tricuspid valve replacement following cardiac resynchronization therapy in a congenitally corrected transposition of the great arteries. 61
31428373 2019
44
Acute Appendicitis in a Patient with Situs Inversus Totalis, Intestinal Malrotation, and Congenitally Corrected Transposition of the Great Arteries. 61
31560326 2019
45
L-looped Transposition of the Great Arteries in a Patient with Marfanoid Habitus: First Reported Case in Literature. 61
31632869 2019
46
Hemodynamically balanced congenitally corrected transposition of the great arteries with a large ventricular septal defect, and subvalvular pulmonic stenosis: a case report. 61
31319891 2019
47
The impact of pulmonary artery banding and cardiac resynchronization therapy for the adult patient with congenitally corrected transposition of the great arteries. 61
31286415 2019
48
Ventricular assist device in a patient with congenitally corrected transposition of the great arteries and situs inversus totalis. 61
30630389 2019
49
Congenitally corrected transposition of the great vessels: evaluation with cardiac magnetic resonance imaging after double-switch repair. 61
30527267 2019
50
3D Printing to Model Surgical Repair of Complex Congenitally Corrected Transposition of the Great Arteries. 61
28825385 2019

Variations for Double Discordia

Expression for Double Discordia

Search GEO for disease gene expression data for Double Discordia.

Pathways for Double Discordia

GO Terms for Double Discordia

Sources for Double Discordia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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