MCID: DBL002
MIFTS: 50

Double Outlet Right Ventricle

Categories: Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Double Outlet Right Ventricle

MalaCards integrated aliases for Double Outlet Right Ventricle:

Name: Double Outlet Right Ventricle 12 76 53 29 6 44 15
Double Outlet Right Ventricle with Subpulmonary Ventricular Septal Defect 12 59
Double Outlet Right Ventricle with Transposition of the Great Arteries 59
Taussig-Bing Syndrome or Defect 12
Dextrotransposition of Aorta 12
Dorv with Subpulmonary Vsd 59
Taussig-Bing Syndrome 59
Dorv-Tga 59

Characteristics:

Orphanet epidemiological data:

59

Classifications:



External Ids:

Disease Ontology 12 DOID:6406
ICD10 33 Q20.1
ICD9CM 35 745.11
MeSH 44 D004310
NCIt 50 C98916
SNOMED-CT 68 7484005
Orphanet 59 ORPHA99045
ICD10 via Orphanet 34 Q20.1
UMLS via Orphanet 74 C1956412 C1956413
UMLS 73 C0013069

Summaries for Double Outlet Right Ventricle

MalaCards based summary : Double Outlet Right Ventricle, also known as double outlet right ventricle with subpulmonary ventricular septal defect, is related to conotruncal heart malformations and transposition of the great arteries. An important gene associated with Double Outlet Right Ventricle is GDF1 (Growth Differentiation Factor 1), and among its related pathways/superpathways are fMLP Pathway and Human Embryonic Stem Cell Pluripotency. The drugs diuretics and Tin Fluorides have been mentioned in the context of this disorder. Affiliated tissues include heart and bone, and related phenotypes are cellular and cardiovascular system

Wikipedia : 76 Double outlet right ventricle (DORV) is a form of congenital heart disease where both of the great... more...

Related Diseases for Double Outlet Right Ventricle

Diseases related to Double Outlet Right Ventricle via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 conotruncal heart malformations 33.7 GATA6 GDF1 NKX2-5 NKX2-6 TBX1 ZFPM2
2 transposition of the great arteries 31.2 GDF1 NKX2-5 ZIC3
3 ventricular septal defect 30.5 GATA4 GATA6 GDF1 HAND1 ISL1 NKX2-5
4 atrioventricular septal defect 30.1 CRELD1 GATA4 GATA6 GDF1 NKX2-5 NKX2-6
5 hypoplastic left heart syndrome 29.8 HAND1 NKX2-5 NKX2-6 TBX20
6 tricuspid atresia 29.6 CRELD1 GDF1 MESP1 NKX2-6 ZFPM2
7 visceral heterotaxy 29.5 CFC1 CRELD1 GDF1 NKX2-6 ZIC3
8 tetralogy of fallot 29.3 CERS1 CRELD1 GATA4 GATA6 GDF1 HAND1
9 atrial heart septal defect 29.2 CFC1 CRELD1 GATA4 GATA6 GDF1 NKX2-5
10 heart disease 28.5 CFC1 CRELD1 GATA4 GATA6 GDF1 HAND1
11 double outlet right ventricle with subaortic or doubly committed ventricular septal defect with pulmonary stenosis 12.8
12 double outlet right ventricle with non-committed subpulmonary ventricular septal defect 12.7
13 double outlet right ventricle with atrioventricular septal defect, pulmonary stenosis, heterotaxy 12.5
14 beemer ertbruggen syndrome 11.9
15 congenital heart defects, multiple types, 6 11.6
16 ritscher-schinzel syndrome 1 11.4
17 complete atrioventricular canal 10.5
18 pulmonic stenosis 10.5
19 dextrocardia 10.5
20 situs inversus 10.4
21 aortopulmonary window 10.4
22 pentalogy of cantrell 10.4
23 cor triatriatum 10.3
24 double discordia 10.3
25 ectopia cordis 10.3
26 heterotaxy 10.2
27 diaphragmatic hernia 3 10.2 ZFPM2 ZFPM2-AS1
28 46,xy sex reversal 9 10.2 ZFPM2 ZFPM2-AS1
29 epilepsy, progressive myoclonic, 8 10.2 CERS1 GDF1
30 46,xy partial gonadal dysgenesis 10.2 GATA4 ZFPM2
31 heterotaxy, visceral, 1, x-linked 10.2
32 thoracoabdominal syndrome 10.2
33 pulmonary hypertension 10.2
34 mitral atresia 10.2
35 criss-cross heart 10.2
36 esophageal atresia/tracheoesophageal fistula 10.1 NKX2-6 TBX1
37 isolated congenitally uncorrected transposition of the great arteries 10.1 CFC1 ZIC3
38 arrhythmogenic right ventricular dysplasia, familial, 5 10.1 MEF2C NKX2-5
39 diaphragmatic hernia, congenital 10.1 GATA4 GATA6 ZFPM2
40 ebstein anomaly 10.1 GATA4 GDF1 NKX2-5 NKX2-6
41 familial atrial fibrillation 10.0 GATA4 GATA6 NKX2-5 NKX2-6
42 holt-oram syndrome 10.0
43 jacobsen syndrome 10.0
44 moebius syndrome 10.0
45 pulmonary hypertension, primary, 1 10.0
46 down syndrome 10.0
47 right atrial isomerism 10.0
48 cleft larynx, posterior 10.0
49 epiphyseal dysplasia, multiple, with early-onset diabetes mellitus 10.0
50 hypoplastic left heart syndrome 1 10.0

Graphical network of the top 20 diseases related to Double Outlet Right Ventricle:



Diseases related to Double Outlet Right Ventricle

Symptoms & Phenotypes for Double Outlet Right Ventricle

MGI Mouse Phenotypes related to Double Outlet Right Ventricle:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.43 CERS1 CRELD1 GATA4 GATA6 GDF1 GPC3
2 cardiovascular system MP:0005385 10.41 CRELD1 GATA4 GATA6 GDF1 GPC3 HAND1
3 growth/size/body region MP:0005378 10.33 CERS1 GATA4 GATA6 GDF1 GPC3 HAND1
4 embryo MP:0005380 10.32 CRELD1 GATA4 GATA6 GDF1 GPC3 HAND1
5 mortality/aging MP:0010768 10.3 CERS1 CRELD1 GATA4 GATA6 GDF1 GPC3
6 craniofacial MP:0005382 10.21 CRELD1 GDF1 GPC3 HAND1 ISL1 MEF2C
7 homeostasis/metabolism MP:0005376 10.21 CERS1 GATA4 GATA6 GPC3 HAND1 ISL1
8 digestive/alimentary MP:0005381 10.1 GATA4 GDF1 GPC3 HAND1 ISL1 NKX2-5
9 nervous system MP:0003631 10.03 CERS1 CRELD1 GATA4 GDF1 HAND1 ISL1
10 muscle MP:0005369 10.02 GATA4 GATA6 HAND1 ISL1 MEF2C MESP1
11 limbs/digits/tail MP:0005371 10.01 GATA4 GATA6 GPC3 HAND1 ISL1 MEF2C
12 normal MP:0002873 9.97 GATA4 GATA6 GDF1 HAND1 ISL1 MEF2C
13 respiratory system MP:0005388 9.77 GATA4 GATA6 GDF1 GPC3 HAND1 MEF2C
14 skeleton MP:0005390 9.36 GATA4 GDF1 GPC3 HAND1 ISL1 MEF2C

Drugs & Therapeutics for Double Outlet Right Ventricle

Drugs for Double Outlet Right Ventricle (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 diuretics
2 Tin Fluorides

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal Defect Completed NCT02361008 Not Applicable
2 Genes Causing Ebstein's Anomaly Completed NCT00497705
3 Surgical Planning for Reconstruction of Complex Heart Defects Recruiting NCT00972608
4 Stress Echo 2020 - The International Stress Echo Study Recruiting NCT03049995
5 Adult Pulmonary Valve Replacement: A Simple and Reproducible Technique Terminated NCT00384163

Search NIH Clinical Center for Double Outlet Right Ventricle

Cochrane evidence based reviews: double outlet right ventricle

Genetic Tests for Double Outlet Right Ventricle

Genetic tests related to Double Outlet Right Ventricle:

# Genetic test Affiliating Genes
1 Double Outlet Right Ventricle 29

Anatomical Context for Double Outlet Right Ventricle

MalaCards organs/tissues related to Double Outlet Right Ventricle:

41
Heart, Bone

Publications for Double Outlet Right Ventricle

Articles related to Double Outlet Right Ventricle:

(show top 50) (show all 450)
# Title Authors Year
1
A Novel MEF2C Loss-of-Function Mutation Associated with Congenital Double Outlet Right Ventricle. ( 29468350 )
2018
2
Double outlet right ventricle with subpulmonary ventricular septal defect (Taussig-Bing anomaly) and other complex congenital cardiac malformations in an American Quarter Horse foal. ( 29174590 )
2018
3
Essential Modifiers of Double Outlet Right Ventricle: Revisit With Endocardial Surface Images and 3-Dimensional Print Models. ( 29855425 )
2018
4
Single-stage repair of double outlet right ventricle with subpulmonic ventricular septal defect (Taussig-Bing anomaly). ( 29485771 )
2018
5
Iatrogenic Gerbode-type defect after surgical correction of double-outlet right ventricle. ( 29984816 )
2018
6
Situs Inversus Double Outlet Right Ventricle With Restrictive Interventricular Communication: Role of Transesophageal Echocardiography. ( 30017592 )
2018
7
Coronary artery anomalies on preoperative cardiac CT in children with tetralogy of Fallot or Fallot type of double outlet right ventricle: comparison with surgical findings. ( 30051301 )
2018
8
An Infant With Neonatal Diabetes and Double Outlet Right Ventricle - Wolcott- Rallison syndrome. ( 30514997 )
2018
9
Surgical Treatment of Double Outlet Right Ventricle with Absent Pulmonary Valve and Bronchiarctia. ( 28345557 )
2017
10
Surgical management of double outlet right ventricle with aortopulmonary window. ( 28247470 )
2017
11
MESP1 lossa89ofa89function mutation contributes to double outlet right ventricle. ( 28677747 )
2017
12
3D Printing in Surgical Management of Double Outlet Right Ventricle. ( 29379778 )
2017
13
Molecular cytogenetic characterization of Jacobsen syndrome (11q23.3-q25 deletion) in a fetus associated with double outlet right ventricle, hypoplastic left heart syndrome and ductus venosus agenesis on prenatal ultrasound. ( 28254208 )
2017
14
Surgical planning for a complex double-outlet right ventricle using 3D printing. ( 28317159 )
2017
15
HAND1 loss-of-function mutation contributes to congenital double outlet right ventricle. ( 28112363 )
2017
16
The independence of the infundibular building blocks in the setting of double-outlet right ventricle. ( 28555539 )
2017
17
Echocardiographic Classification and Surgical Approaches to Double-Outlet Right Ventricle for Great Arteries Arising Almost Exclusively from the Right Ventricle. ( 28878577 )
2017
18
Double outlet right ventricle with absent infundibular septum and common ventriculo-arterial valve. ( 28421590 )
2017
19
Conuses and discontinuities: To be or not to be in double-outlet right ventricle. ( 28477947 )
2017
20
Xq26.1-26.3 duplication including MOSPD1 and GPC3 identified in boy with short stature and double outlet right ventricle. ( 28636109 )
2017
21
Double-outlet right ventricle revisited. ( 28528718 )
2017
22
Catheter Ablation of Peri-Conduit Ventricular Tachycardia in a Patient with Rastelli Procedure for Double Outlet Right Ventricle with Malposition of Great Arteries. ( 28765748 )
2017
23
Biventricular Repair of Double Outlet Right Ventricle: Preoperative Echocardiography and Surgical Outcomes. ( 29148310 )
2017
24
Surgical Treatment of Double Outlet Right Ventricle Complicated by Pulmonary Hypertension. ( 28218213 )
2017
25
Double Outlet Right Ventricle With Right-Sided Aorta From the Left-Sided Morphologically Right Ventricle in the Setting of Discordant Atrioventricular Connections. ( 28933246 )
2017
26
Anatomical Classifications of the Coronary Arteries in Complete Transposition of the Great Arteries and Double Outlet Right Ventricle with Subpulmonary Ventricular Septal Defect. ( 26935177 )
2017
27
How should we diagnose and differentiate hearts with double-outlet right ventricle? ( 27641710 )
2017
28
Utility and Scope of Rapid Prototyping in Patients with Complex Muscular Ventricular Septal Defects or Double-Outlet Right Ventricle: Does it Alter Management Decisions? ( 27837304 )
2017
29
The concept of double inlet-double outlet right ventricle: a distinct congenital heart disease. ( 27866077 )
2017
30
Point catheter ablation of macro-re-entrant ventricular tachycardia in a patient after surgical repair for double-outlet right ventricle. ( 28077188 )
2017
31
Double-outlet right ventricle with an intact interventricular septum and concurrent hypoplastic left ventricle in a calf. ( 28111139 )
2017
32
Anaesthetic management in a patient of uncorrected double outlet right ventricle for emergency surgery. ( 28216717 )
2017
33
Atypical Circular Shunt and Diffuse Emphysema in a Fetus with Double-Outlet Right Ventricle and Absent Pulmonary Valve. ( 30062290 )
2017
34
Double-Outlet Right Ventricle With Noncommitted Ventricular Septal Defect and 2 Adequate Ventricles: Is Anatomical Repair Advantageous? ( 27568139 )
2016
35
Double Outlet Right Ventricle with Noncommitted Ventricular Septal Defect and Two Adequate Ventricles: is Anatomical Repair Advantageous? ( 27568140 )
2016
36
Clinical Application and Multidisciplinary Assessment of Three Dimensional Printing in Double Outlet Right Ventricle With Remote Ventricular Septal Defect. ( 27142402 )
2016
37
Application of Virtual Three-Dimensional Models for Simultaneous Visualization of Intracardiac Anatomic Relationships in Double Outlet Right Ventricle. ( 26254102 )
2016
38
Double Outlet Right Ventricle With Intact Ventricular Septum: Avulsion or Exclusion. ( 26603090 )
2016
39
Surgically Constructed Double-Outlet Right Ventricle. ( 26903020 )
2016
40
Complete transposition of the great arteries with double outlet right ventricle in a dog. ( 26936424 )
2016
41
GATA5 mutation homozygosity linked to a double outlet right ventricle phenotype in a Lebanese patient. ( 27066509 )
2016
42
Anesthetic management for cesarean section in a patient with uncorrected double-outlet right ventricle. ( 27069835 )
2016
43
Aortic Root Translocation with Arterial Switch for Transposition of the Great Arteries or Double Outlet Right Ventricle with Ventricular Septal Defect and Pulmonary Stenosis. ( 27298797 )
2016
44
Impact of anatomic characteristics and initial biventricular surgical strategy on outcomes in various forms of double-outlet right ventricle. ( 27345579 )
2016
45
Three-Dimensional Reconstruction of Intracardiac Anatomy Using CTA and Surgical Planning for Double Outlet Right Ventricle: Early Experience at a Tertiary Care Congenital Heart Center. ( 27358302 )
2016
46
Letter by Murakami et al Regarding Article, "Surgically Constructed Double-Outlet Right Ventricle". ( 27436886 )
2016
47
Double Outlet Right Ventricle: Where are we Now? ( 27568141 )
2016
48
Right ventricular outflow tract stenting in double outlet right ventricle with critical pulmonary stenosis and hypoplastic pulmonary arteries. ( 27625692 )
2016
49
Surgical Treatment for Double Outlet Right Ventricle With Pulmonary Outflow Tract Obstruction. ( 27834760 )
2016
50
Surgical approach to a rare case of double-outlet right ventricle and aortopulmonary window. ( 25737002 )
2015

Variations for Double Outlet Right Ventricle

ClinVar genetic disease variations for Double Outlet Right Ventricle:

6 (show all 13)
# Gene Variation Type Significance SNP ID Assembly Location
1 ZFPM2 NM_012082.3(ZFPM2): c.89A> G (p.Glu30Gly) single nucleotide variant Likely benign rs121908601 GRCh37 Chromosome 8, 106431420: 106431420
2 ZFPM2 NM_012082.3(ZFPM2): c.89A> G (p.Glu30Gly) single nucleotide variant Likely benign rs121908601 GRCh38 Chromosome 8, 105419192: 105419192
3 ZFPM2 NM_012082.3(ZFPM2): c.2107A> C (p.Met703Leu) single nucleotide variant Pathogenic rs121908603 GRCh37 Chromosome 8, 106814417: 106814417
4 ZFPM2 NM_012082.3(ZFPM2): c.2107A> C (p.Met703Leu) single nucleotide variant Pathogenic rs121908603 GRCh38 Chromosome 8, 105802189: 105802189
5 GDF1 NM_001492.5(GDF1): c.800G> A (p.Cys267Tyr) single nucleotide variant Pathogenic rs121434423 GRCh37 Chromosome 19, 18979725: 18979725
6 GDF1 NM_001492.5(GDF1): c.800G> A (p.Cys267Tyr) single nucleotide variant Pathogenic rs121434423 GRCh38 Chromosome 19, 18868916: 18868916
7 NKX2-5 NKX2-5, 3-BP DEL, 871AAC deletion Pathogenic
8 ZFPM2 NM_012082.3(ZFPM2): c.681T> G (p.Ile227Met) single nucleotide variant Pathogenic rs397514520 GRCh37 Chromosome 8, 106801094: 106801094
9 ZFPM2 NM_012082.3(ZFPM2): c.681T> G (p.Ile227Met) single nucleotide variant Pathogenic rs397514520 GRCh38 Chromosome 8, 105788866: 105788866
10 ZFPM2 NM_012082.3(ZFPM2): c.2209A> G (p.Lys737Glu) single nucleotide variant Pathogenic rs397514521 GRCh37 Chromosome 8, 106814519: 106814519
11 ZFPM2 NM_012082.3(ZFPM2): c.2209A> G (p.Lys737Glu) single nucleotide variant Pathogenic rs397514521 GRCh38 Chromosome 8, 105802291: 105802291
12 MYCN NM_005378.5(MYCN): c.1226C> T (p.Pro409Leu) single nucleotide variant Uncertain significance GRCh37 Chromosome 2, 16086050: 16086050
13 MYCN NM_005378.5(MYCN): c.1226C> T (p.Pro409Leu) single nucleotide variant Uncertain significance GRCh38 Chromosome 2, 15945928: 15945928

Expression for Double Outlet Right Ventricle

Search GEO for disease gene expression data for Double Outlet Right Ventricle.

Pathways for Double Outlet Right Ventricle

GO Terms for Double Outlet Right Ventricle

Cellular components related to Double Outlet Right Ventricle according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.8 GATA4 GATA6 HAND1 ISL1 MEF2C MESP1
2 RNA polymerase II transcription factor complex GO:0090575 8.8 GATA4 HAND1 NKX2-5

Biological processes related to Double Outlet Right Ventricle according to GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of canonical Wnt signaling pathway GO:0090090 9.89 GPC3 ISL1 NKX2-5
2 animal organ morphogenesis GO:0009887 9.88 GATA4 GATA6 GPC3
3 heart morphogenesis GO:0003007 9.88 ISL1 MESP1 NKX2-5 TBX1
4 outflow tract morphogenesis GO:0003151 9.88 ISL1 MEF2C NKX2-5 TBX1 TBX20
5 anterior/posterior pattern specification GO:0009952 9.87 CFC1 TBX1 ZIC3
6 lung development GO:0030324 9.87 GPC3 ZFPM2 ZIC3
7 BMP signaling pathway GO:0030509 9.86 CFC1 GDF1 NKX2-5
8 positive regulation of cardiac muscle cell proliferation GO:0060045 9.86 GATA6 MEF2C TBX20 ZFPM2
9 determination of left/right symmetry GO:0007368 9.85 CFC1 TBX1 ZIC3
10 pattern specification process GO:0007389 9.84 TBX1 UNCX ZIC3
11 negative regulation of epithelial cell proliferation GO:0050680 9.83 GPC3 ISL1 MEF2C
12 cell development GO:0048468 9.83 GATA4 GATA6 GDF1
13 embryonic heart tube development GO:0035050 9.81 HAND1 NKX2-5 NKX2-6 TBX20
14 pharyngeal system development GO:0060037 9.8 ISL1 NKX2-5 NKX2-6 TBX1
15 cardiac muscle cell differentiation GO:0055007 9.8 GATA4 GATA6 MEF2C MESP1 NKX2-5
16 positive regulation of BMP signaling pathway GO:0030513 9.79 GATA4 GATA6 GPC3
17 cardiac muscle tissue development GO:0048738 9.77 GATA6 NKX2-5 ZFPM2
18 cardiac right ventricle morphogenesis GO:0003215 9.77 GATA4 ISL1 TBX20
19 atrial septum morphogenesis GO:0060413 9.76 GATA4 ISL1 NKX2-5 TBX20
20 secondary heart field specification GO:0003139 9.74 ISL1 MEF2C MESP1
21 thyroid gland development GO:0030878 9.72 NKX2-5 TBX1
22 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.72 HAND1 ISL1
23 anatomical structure formation involved in morphogenesis GO:0048646 9.71 GATA4 GATA6
24 tissue development GO:0009888 9.71 GATA4 GATA6
25 aortic valve morphogenesis GO:0003180 9.71 GATA4 TBX20
26 cardiac muscle tissue morphogenesis GO:0055008 9.71 NKX2-5 TBX20
27 positive regulation of cardioblast differentiation GO:0051891 9.71 GATA4 GATA6 NKX2-5
28 endocardial cushion morphogenesis GO:0003203 9.7 ISL1 TBX20
29 cardiac muscle hypertrophy in response to stress GO:0014898 9.7 GATA6 MEF2C
30 cardiac ventricle formation GO:0003211 9.7 MEF2C MESP1 NKX2-5
31 cardiac septum development GO:0003279 9.69 CRELD1 TBX20
32 smooth muscle cell differentiation GO:0051145 9.69 GATA6 MEF2C
33 endocardial cushion development GO:0003197 9.68 CRELD1 GATA4
34 embryonic viscerocranium morphogenesis GO:0048703 9.68 MEF2C TBX1
35 cardiac ventricle morphogenesis GO:0003208 9.68 GATA4 NKX2-5
36 ventricular cardiac muscle cell development GO:0055015 9.67 NKX2-5 NKX2-6
37 embryonic heart tube morphogenesis GO:0003143 9.67 MESP1 TBX20
38 cartilage morphogenesis GO:0060536 9.65 HAND1 MEF2C
39 intestinal epithelial cell differentiation GO:0060575 9.65 GATA4 GATA6
40 atrial cardiac muscle cell development GO:0055014 9.64 NKX2-5 NKX2-6
41 cardiac cell fate determination GO:0060913 9.63 ISL1 MESP1
42 cardiac vascular smooth muscle cell differentiation GO:0060947 9.63 GATA6 MESP1
43 outflow tract septum morphogenesis GO:0003148 9.63 GATA6 ISL1 NKX2-5 TBX1 TBX20 ZFPM2
44 visceral motor neuron differentiation GO:0021524 9.62 ISL1 TBX20
45 right ventricular cardiac muscle tissue morphogenesis GO:0003221 9.61 NKX2-5 ZFPM2
46 heart looping GO:0001947 9.5 GATA4 HAND1 MEF2C MESP1 NKX2-5 TBX20
47 heart development GO:0007507 9.32 CFC1 GATA4 GATA6 HAND1 ISL1 MEF2C
48 regulation of transcription, DNA-templated GO:0006355 10.26 GATA4 GATA6 ISL1 MEF2C NKX2-5 NKX2-6
49 cell differentiation GO:0030154 10.2 HAND1 ISL1 MEF2C MOSPD1 NKX2-5 NKX2-6
50 negative regulation of transcription by RNA polymerase II GO:0000122 10.19 GATA6 HAND1 ISL1 MEF2C MOSPD1 NKX2-5

Molecular functions related to Double Outlet Right Ventricle according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.89 GATA4 GATA6 HAND1 NKX2-5 ZFPM2
2 transcription coactivator activity GO:0003713 9.88 GATA4 HAND1 ISL1 TBX20 ZFPM2
3 transcription regulatory region DNA binding GO:0044212 9.88 GATA4 GATA6 HAND1 MEF2C MESP1 NKX2-5
4 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 9.86 GATA4 GATA6 ISL1 MEF2C MESP1 NKX2-5
5 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.85 GATA4 MEF2C NKX2-6 TBX20 ZIC3
6 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.81 GATA4 GATA6 HAND1 ISL1 MEF2C MESP1
7 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.7 GATA6 MEF2C NKX2-5
8 RNA polymerase II transcription factor binding GO:0001085 9.69 GATA4 TBX20 ZFPM2
9 sequence-specific DNA binding GO:0043565 9.65 GATA4 GATA6 HAND1 ISL1 MEF2C NKX2-5
10 enhancer sequence-specific DNA binding GO:0001158 9.61 GATA4 GATA6 ISL1
11 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.44 GATA4 GATA6 HAND1 ISL1 MEF2C MESP1
12 DNA binding GO:0003677 10.13 GATA4 GATA6 HAND1 ISL1 MEF2C MESP1
13 DNA-binding transcription factor activity GO:0003700 10.02 GATA4 GATA6 MEF2C MESP1 NKX2-5 NKX2-6

Sources for Double Outlet Right Ventricle

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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