MCID: DBL002
MIFTS: 49

Double Outlet Right Ventricle

Categories: Rare diseases, Cardiovascular diseases, Fetal diseases

Aliases & Classifications for Double Outlet Right Ventricle

MalaCards integrated aliases for Double Outlet Right Ventricle:

Name: Double Outlet Right Ventricle 12 76 53 29 6 44 15
Double Outlet Right Ventricle with Subpulmonary Ventricular Septal Defect 12 59
Double Outlet Right Ventricle with Transposition of the Great Arteries 59
Taussig-Bing Syndrome or Defect 12
Dextrotransposition of Aorta 12
Dorv with Subpulmonary Vsd 59
Taussig-Bing Syndrome 59
Dorv-Tga 59

Characteristics:

Orphanet epidemiological data:

59

Classifications:



External Ids:

Disease Ontology 12 DOID:6406
ICD10 33 Q20.1
ICD9CM 35 745.11
MeSH 44 D004310
NCIt 50 C98916
Orphanet 59 ORPHA99045
ICD10 via Orphanet 34 Q20.1
UMLS via Orphanet 74 C1956412 C1956413
UMLS 73 C0013069

Summaries for Double Outlet Right Ventricle

MalaCards based summary : Double Outlet Right Ventricle, also known as double outlet right ventricle with subpulmonary ventricular septal defect, is related to conotruncal heart malformations and transposition of the great arteries. An important gene associated with Double Outlet Right Ventricle is GDF1 (Growth Differentiation Factor 1), and among its related pathways/superpathways are Mesodermal Commitment Pathway and Signaling pathways regulating pluripotency of stem cells. The drugs diuretics and Tin Fluorides have been mentioned in the context of this disorder. Affiliated tissues include heart and bone, and related phenotypes are cellular and cardiovascular system

Wikipedia : 76 Double outlet right ventricle (DORV) is a form of congenital heart disease where both of the great... more...

Related Diseases for Double Outlet Right Ventricle

Diseases related to Double Outlet Right Ventricle via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 conotruncal heart malformations 32.9 CFC1 GATA6 GDF1 NKX2-5 NKX2-6 TBX1
2 transposition of the great arteries 31.1 GDF1 NKX2-5 ZFPM2 ZIC3
3 ventricular septal defect 30.3 GATA4 GATA6 GDF1 ISL1 NKX2-5 NKX2-6
4 visceral heterotaxy 30.0 CFC1 GDF1 ZIC3
5 hypoplastic left heart syndrome 29.5 HAND1 NKX2-5 NKX2-6 TBX20
6 atrioventricular septal defect 29.0 CRELD1 GATA4 GATA6 GDF1 NKX2-5 NKX2-6
7 tricuspid atresia 28.7 CRELD1 GDF1 MESP1 NKX2-5 NKX2-6 ZFPM2
8 atrial heart septal defect 27.7 CFC1 CRELD1 GATA4 GATA6 GDF1 NKX2-5
9 tetralogy of fallot 26.0 CERS1 CRELD1 GATA4 GATA6 GDF1 HAND1
10 heart disease 25.4 CFC1 CRELD1 GATA4 GATA6 GDF1 HAND1
11 double outlet right ventricle with subaortic or doubly committed ventricular septal defect with pulmonary stenosis 12.7
12 double outlet right ventricle with non-committed subpulmonary ventricular septal defect 12.5
13 double outlet right ventricle with atrioventricular septal defect, pulmonary stenosis, heterotaxy 12.4
14 beemer ertbruggen syndrome 11.7
15 ritscher-schinzel syndrome 1 11.3
16 congenital heart defects, multiple types, 6 11.3
17 diaphragmatic hernia 3 10.7 ZFPM2 ZFPM2-AS1
18 46,xy sex reversal 9 10.7 ZFPM2 ZFPM2-AS1
19 epilepsy, progressive myoclonic, 8 10.5 CERS1 GDF1
20 isolated congenitally uncorrected transposition of the great arteries 10.5 CFC1 ZIC3
21 46,xy partial gonadal dysgenesis 10.4 GATA4 ZFPM2
22 complete atrioventricular canal 10.4
23 pulmonic stenosis 10.4
24 dextrocardia 10.3
25 pulmonary valve stenosis 10.3 GATA4 NKX2-6
26 diaphragmatic hernia, congenital 10.3 GATA4 GATA6 ZFPM2
27 aortopulmonary window 10.3
28 esophageal atresia/tracheoesophageal fistula 10.3 NKX2-6 TBX1
29 patent foramen ovale 10.3 GATA4 NKX2-5 TBX20
30 situs inversus 10.2
31 pentalogy of cantrell 10.2
32 cor triatriatum 10.2
33 double discordia 10.2
34 aneurysm 10.2
35 ectopia cordis 10.2
36 complete atrioventricular canal-tetralogy of fallot syndrome 10.1 CRELD1 GATA4
37 familial atrial fibrillation 10.1 GATA4 GATA6 NKX2-5 NKX2-6
38 heterotaxy 10.1
39 complete atrioventricular canal-left heart obstruction syndrome 10.1 CRELD1 GATA4
40 total anomalous pulmonary venous return 1 10.1 CRELD1 GDF1 NKX2-6
41 dextro-looped transposition of the great arteries 10.1 CFC1 GDF1 NKX2-6 ZIC3
42 atrial septal defect 4 10.1 GATA4 GATA6 NKX2-5 TBX20
43 heterotaxy, visceral, 1, x-linked 10.0
44 mitral atresia 10.0
45 criss-cross heart 10.0
46 partial atrioventricular canal 10.0 CRELD1 GATA4 GATA6
47 complete atrioventricular canal-ventricle hypoplasia syndrome 10.0 CRELD1 GATA4 GATA6
48 holt-oram syndrome 9.9
49 jacobsen syndrome 9.9
50 moebius syndrome 9.9

Graphical network of the top 20 diseases related to Double Outlet Right Ventricle:



Diseases related to Double Outlet Right Ventricle

Symptoms & Phenotypes for Double Outlet Right Ventricle

MGI Mouse Phenotypes related to Double Outlet Right Ventricle:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.43 ISL1 NKX2-5 LIMS1 HAND1 MESP1 GATA6
2 cardiovascular system MP:0005385 10.41 ISL1 NKX2-5 LIMS1 HAND1 MESP1 CRELD1
3 growth/size/body region MP:0005378 10.33 ISL1 NKX2-5 LIMS1 HAND1 MESP1 GATA6
4 embryo MP:0005380 10.32 NKX2-5 LIMS1 HAND1 MESP1 ISL1 CRELD1
5 mortality/aging MP:0010768 10.3 ISL1 NKX2-5 LIMS1 HAND1 MESP1 GATA6
6 homeostasis/metabolism MP:0005376 10.25 MESP1 ISL1 LIMS1 HAND1 CERS1 GATA6
7 craniofacial MP:0005382 10.16 MESP1 ISL1 HAND1 CRELD1 GDF1 GPC3
8 digestive/alimentary MP:0005381 10.1 ZIC3 ISL1 HAND1 GDF1 GATA4 GPC3
9 muscle MP:0005369 10.02 MESP1 ISL1 LIMS1 HAND1 GATA6 GATA4
10 nervous system MP:0003631 10 ZIC3 MESP1 ISL1 HAND1 CERS1 CRELD1
11 normal MP:0002873 9.97 ISL1 NKX2-5 LIMS1 HAND1 MESP1 GATA6
12 limbs/digits/tail MP:0005371 9.95 ZIC3 ISL1 HAND1 GATA6 GATA4 GPC3
13 respiratory system MP:0005388 9.77 NKX2-5 LIMS1 HAND1 MESP1 GDF1 GATA4
14 skeleton MP:0005390 9.32 MESP1 MOSPD1 ISL1 HAND1 GDF1 GATA4

Drugs & Therapeutics for Double Outlet Right Ventricle

Drugs for Double Outlet Right Ventricle (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 diuretics
2 Tin Fluorides

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Controlled Trial:Treatments on Infundibular Ventricular Septal Defect Completed NCT02361008 Not Applicable
2 Genes Causing Ebstein's Anomaly Completed NCT00497705
3 Surgical Planning for Reconstruction of Complex Heart Defects Recruiting NCT00972608
4 Stress Echo 2020 - The International Stress Echo Study Recruiting NCT03049995
5 Adult Pulmonary Valve Replacement: A Simple and Reproducible Technique Terminated NCT00384163

Search NIH Clinical Center for Double Outlet Right Ventricle

Cochrane evidence based reviews: double outlet right ventricle

Genetic Tests for Double Outlet Right Ventricle

Genetic tests related to Double Outlet Right Ventricle:

# Genetic test Affiliating Genes
1 Double Outlet Right Ventricle 29

Anatomical Context for Double Outlet Right Ventricle

MalaCards organs/tissues related to Double Outlet Right Ventricle:

41
Heart, Bone

Publications for Double Outlet Right Ventricle

Articles related to Double Outlet Right Ventricle:

(show top 50) (show all 417)
# Title Authors Year
1
A Novel MEF2C Loss-of-Function Mutation Associated with Congenital Double Outlet Right Ventricle. ( 29468350 )
2018
2
Double outlet right ventricle with subpulmonary ventricular septal defect (Taussig-Bing anomaly) and other complex congenital cardiac malformations in an American Quarter Horse foal. ( 29174590 )
2018
3
Essential Modifiers of Double Outlet Right Ventricle: Revisit With Endocardial Surface Images and 3-Dimensional Print Models. ( 29855425 )
2018
4
Single-stage repair of double outlet right ventricle with subpulmonic ventricular septal defect (Taussig-Bing anomaly). ( 29485771 )
2018
5
Surgical Treatment of Double Outlet Right Ventricle with Absent Pulmonary Valve and Bronchiarctia. ( 28345557 )
2017
6
Surgical management of double outlet right ventricle with aortopulmonary window. ( 28247470 )
2017
7
MESP1 lossa89ofa89function mutation contributes to double outlet right ventricle. ( 28677747 )
2017
8
3D Printing in Surgical Management of Double Outlet Right Ventricle. ( 29379778 )
2017
9
Molecular cytogenetic characterization of Jacobsen syndrome (11q23.3-q25 deletion) in a fetus associated with double outlet right ventricle, hypoplastic left heart syndrome and ductus venosus agenesis on prenatal ultrasound. ( 28254208 )
2017
10
Surgical planning for a complex double-outlet right ventricle using 3D printing. ( 28317159 )
2017
11
HAND1 loss-of-function mutation contributes to congenital double outlet right ventricle. ( 28112363 )
2017
12
The independence of the infundibular building blocks in the setting of double-outlet right ventricle. ( 28555539 )
2017
13
Echocardiographic Classification and Surgical Approaches to Double-Outlet Right Ventricle for Great Arteries Arising Almost Exclusively from the Right Ventricle. ( 28878577 )
2017
14
Double outlet right ventricle with absent infundibular septum and common ventriculo-arterial valve. ( 28421590 )
2017
15
Conuses and discontinuities: To be or not to be in double-outlet right ventricle. ( 28477947 )
2017
16
Xq26.1-26.3 duplication including MOSPD1 and GPC3 identified in boy with short stature and double outlet right ventricle. ( 28636109 )
2017
17
Double-outlet right ventricle revisited. ( 28528718 )
2017
18
Catheter Ablation of Peri-Conduit Ventricular Tachycardia in a Patient with Rastelli Procedure for Double Outlet Right Ventricle with Malposition of Great Arteries. ( 28765748 )
2017
19
Biventricular Repair of Double Outlet Right Ventricle: Preoperative Echocardiography and Surgical Outcomes. ( 29148310 )
2017
20
Surgical Treatment of Double Outlet Right Ventricle Complicated by Pulmonary Hypertension. ( 28218213 )
2017
21
Double Outlet Right Ventricle With Right-Sided Aorta From the Left-Sided Morphologically Right Ventricle in the Setting of Discordant Atrioventricular Connections. ( 28933246 )
2017
22
Double-Outlet Right Ventricle With Noncommitted Ventricular Septal Defect and 2 Adequate Ventricles: Is Anatomical Repair Advantageous? ( 27568139 )
2016
23
Double Outlet Right Ventricle with Noncommitted Ventricular Septal Defect and Two Adequate Ventricles: is Anatomical Repair Advantageous? ( 27568140 )
2016
24
Clinical Application and Multidisciplinary Assessment of Three Dimensional Printing in Double Outlet Right Ventricle With Remote Ventricular Septal Defect. ( 27142402 )
2016
25
Surgical approach to a rare case of double-outlet right ventricle and aortopulmonary window. ( 25737002 )
2015
26
The Triply Twisted Heart: Cyanosis in an Adult With Situs Inversus, Levocardia, Double Outlet Right Ventricle, and Malposition of the Great Arteries. ( 28197259 )
2015
27
Biventricular repair for double outlet right ventricle with non-committed ventricular septal defecta8 ( 25612745 )
2015
28
Ectopia cordis with a double outlet right ventricle, large ventricular septal defect, malposed great arteries and left ventricular hypoplasia. ( 25409882 )
2015
29
A case of pentalogy of Cantrell with double outlet right ventricle. ( 26458354 )
2015
30
Biventricular repair of double-outlet right ventricle and closing ventricular septal defect. ( 25555952 )
2015
31
TBX20 loss-of-function mutation contributes to double outlet right ventricle. ( 25625280 )
2015
32
Perioperative management of combined surgery for phaeochromocytoma and double outlet right ventricle: A rare combination. ( 26195836 )
2015
33
Persistent 5th aortic arch with coexisting discontinuous pulmonary arteries, double-outlet right ventricle, and complete atrioventricular septal defect. ( 25873812 )
2015
34
De Novo interstitial deletion 13q33.3q34 in a male patient with double outlet right ventricle, microcephaly, dysmorphic craniofacial findings, and motor and developmental delay. ( 25810372 )
2015
35
Use of 3-dimensional printing to demonstrate complex intracardiac relationships in double-outlet right ventricle for surgical planning. ( 25904574 )
2015
36
Reply: Anatomically corrected malposition or double outlet right ventricle? ( 24668995 )
2014
37
Surgical outcomes of 380 patients with double outlet right ventricle who underwent biventricular repair. ( 24997522 )
2014
38
Double outlet right ventricle, atrioventricular canal defect with severe pulmonary artery stenosis: a rare cyanotic congenital heart disease. ( 25252539 )
2014
39
Challenges of classifying double outlet right ventricle: importance for genotype-phenotype analyses. ( 24664979 )
2014
40
Double outlet right ventricle with intact ventricular septum. ( 24643154 )
2014
41
Anatomically corrected malposition or double outlet right ventricle? ( 24668994 )
2014
42
Management of Pentalogy of Cantrell with complete ectopia cordis and Double Outlet Right Ventricle. ( 25385246 )
2014
43
Identification of novel significant variants of ZFPM2/FOG2 in non-syndromic Tetralogy of Fallot and double outlet right ventricle in a Chinese Han population. ( 24469719 )
2014
44
From Marfan's Syndrome to Double Outlet Right Ventricle-And Everything in Between. ( 25104837 )
2014
45
Accessory tricuspid valve leaflet and an anomalous muscle bundle in the right ventricular outflow tract in a patient with double-outlet right ventricle: a rare case report. ( 24646094 )
2014
46
Successful biventricular repair of double-outlet right ventricle with transposition of the great arteries, pulmonary stenosis, and straddling mitral valve. ( 24694423 )
2014
47
Aortopulmonary window and double outlet right ventricle: a rare combination. ( 24994739 )
2014
48
Abnormal origin of the left subclavian artery from the left pulmonary artery in a patient with double outlet right ventricle. ( 24570863 )
2014
49
Case of double-outlet right ventricle after repair with pulmonary arteriovenous malformations using cardiac CT. ( 24998091 )
2014
50
Combined obstructive hypertrophic cardiomyopathy and double outlet right ventricle in an infant with Down syndrome. ( 24222815 )
2013

Variations for Double Outlet Right Ventricle

ClinVar genetic disease variations for Double Outlet Right Ventricle:

6
(show all 11)
# Gene Variation Type Significance SNP ID Assembly Location
1 ZFPM2 NM_012082.3(ZFPM2): c.2107A> C (p.Met703Leu) single nucleotide variant Pathogenic rs121908603 GRCh37 Chromosome 8, 106814417: 106814417
2 ZFPM2 NM_012082.3(ZFPM2): c.2107A> C (p.Met703Leu) single nucleotide variant Pathogenic rs121908603 GRCh38 Chromosome 8, 105802189: 105802189
3 GDF1 NM_001492.5(GDF1): c.800G> A (p.Cys267Tyr) single nucleotide variant Pathogenic rs121434423 GRCh37 Chromosome 19, 18979725: 18979725
4 GDF1 NM_001492.5(GDF1): c.800G> A (p.Cys267Tyr) single nucleotide variant Pathogenic rs121434423 GRCh38 Chromosome 19, 18868916: 18868916
5 NKX2-5 NKX2-5, 3-BP DEL, 871AAC deletion Pathogenic
6 ZFPM2 NM_012082.3(ZFPM2): c.681T> G (p.Ile227Met) single nucleotide variant Pathogenic rs397514520 GRCh37 Chromosome 8, 106801094: 106801094
7 ZFPM2 NM_012082.3(ZFPM2): c.681T> G (p.Ile227Met) single nucleotide variant Pathogenic rs397514520 GRCh38 Chromosome 8, 105788866: 105788866
8 ZFPM2 NM_012082.3(ZFPM2): c.2209A> G (p.Lys737Glu) single nucleotide variant Pathogenic rs397514521 GRCh37 Chromosome 8, 106814519: 106814519
9 ZFPM2 NM_012082.3(ZFPM2): c.2209A> G (p.Lys737Glu) single nucleotide variant Pathogenic rs397514521 GRCh38 Chromosome 8, 105802291: 105802291
10 MYCN NM_005378.5(MYCN): c.1226C> T (p.Pro409Leu) single nucleotide variant Uncertain significance GRCh37 Chromosome 2, 16086050: 16086050
11 MYCN NM_005378.5(MYCN): c.1226C> T (p.Pro409Leu) single nucleotide variant Uncertain significance GRCh38 Chromosome 2, 15945928: 15945928

Expression for Double Outlet Right Ventricle

Search GEO for disease gene expression data for Double Outlet Right Ventricle.

Pathways for Double Outlet Right Ventricle

GO Terms for Double Outlet Right Ventricle

Cellular components related to Double Outlet Right Ventricle according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II transcription factor complex GO:0090575 8.8 GATA4 HAND1 NKX2-5

Biological processes related to Double Outlet Right Ventricle according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.87 GATA4 GATA6 GPC3
2 anterior/posterior pattern specification GO:0009952 9.87 CFC1 TBX1 ZIC3
3 BMP signaling pathway GO:0030509 9.86 CFC1 GDF1 NKX2-5
4 lung development GO:0030324 9.86 GPC3 ZFPM2 ZIC3
5 determination of left/right symmetry GO:0007368 9.85 CFC1 TBX1 ZIC3
6 outflow tract morphogenesis GO:0003151 9.84 ISL1 NKX2-5 TBX1 TBX20
7 cell development GO:0048468 9.83 GATA4 GATA6 GDF1
8 pattern specification process GO:0007389 9.83 TBX1 UNCX ZIC3
9 heart morphogenesis GO:0003007 9.83 ISL1 MESP1 NKX2-5 TBX1
10 digestive tract development GO:0048565 9.82 GATA4 GATA6 NKX2-6
11 positive regulation of cardiac muscle cell proliferation GO:0060045 9.81 GATA6 TBX20 ZFPM2
12 positive regulation of BMP signaling pathway GO:0030513 9.81 GATA4 GATA6 GPC3
13 cardiac muscle cell differentiation GO:0055007 9.78 GATA4 GATA6 MESP1 NKX2-5
14 cardiac muscle tissue development GO:0048738 9.77 GATA6 NKX2-5 ZFPM2
15 embryonic heart tube development GO:0035050 9.76 HAND1 NKX2-5 NKX2-6 TBX20
16 cardiac right ventricle morphogenesis GO:0003215 9.74 GATA4 ISL1 TBX20
17 pharyngeal system development GO:0060037 9.73 ISL1 NKX2-5 NKX2-6 TBX1
18 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.7 HAND1 ISL1
19 anatomical structure formation involved in morphogenesis GO:0048646 9.7 GATA4 GATA6
20 cardiac muscle tissue morphogenesis GO:0055008 9.7 NKX2-5 TBX20
21 endocardial cushion morphogenesis GO:0003203 9.69 ISL1 TBX20
22 cardiac septum development GO:0003279 9.68 CRELD1 TBX20
23 endocardial cushion development GO:0003197 9.68 CRELD1 GATA4
24 ventricular cardiac muscle cell development GO:0055015 9.68 NKX2-5 NKX2-6
25 cardiac ventricle morphogenesis GO:0003208 9.67 GATA4 NKX2-5
26 secondary heart field specification GO:0003139 9.67 ISL1 MESP1
27 positive regulation of cardioblast differentiation GO:0051891 9.67 GATA4 GATA6 NKX2-5
28 embryonic heart tube morphogenesis GO:0003143 9.66 MESP1 TBX20
29 intestinal epithelial cell differentiation GO:0060575 9.65 GATA4 GATA6
30 cardiac ventricle formation GO:0003211 9.65 MESP1 NKX2-5
31 atrial cardiac muscle cell development GO:0055014 9.63 NKX2-5 NKX2-6
32 heart looping GO:0001947 9.63 GATA4 HAND1 MESP1 NKX2-5 TBX20 ZIC3
33 visceral motor neuron differentiation GO:0021524 9.62 ISL1 TBX20
34 cardiac vascular smooth muscle cell differentiation GO:0060947 9.62 GATA6 MESP1
35 atrial septum morphogenesis GO:0060413 9.62 GATA4 ISL1 NKX2-5 TBX20
36 cardiac cell fate determination GO:0060913 9.61 ISL1 MESP1
37 heart development GO:0007507 9.61 CFC1 GATA4 GATA6 HAND1 ISL1 NKX2-5
38 right ventricular cardiac muscle tissue morphogenesis GO:0003221 9.6 NKX2-5 ZFPM2
39 outflow tract septum morphogenesis GO:0003148 9.1 GATA6 ISL1 NKX2-5 TBX1 TBX20 ZFPM2
40 regulation of transcription, DNA-templated GO:0006355 10.33 GATA4 GATA6 HAND1 ISL1 MESP1 NKX2-5
41 transcription, DNA-templated GO:0006351 10.32 GATA4 GATA6 HAND1 ISL1 MESP1 NKX2-6
42 multicellular organism development GO:0007275 10.21 CFC1 HAND1 ISL1 MESP1 NKX2-5 NKX2-6
43 cell differentiation GO:0030154 10.19 HAND1 ISL1 MOSPD1 NKX2-5 NKX2-6 UNCX
44 negative regulation of transcription by RNA polymerase II GO:0000122 10.15 GATA6 HAND1 ISL1 MOSPD1 NKX2-5 TBX20
45 negative regulation of transcription, DNA-templated GO:0045892 10.1 GATA6 HAND1 LIMS1 MESP1 NKX2-5 TBX20
46 transcription by RNA polymerase II GO:0006366 10.06 GATA4 GATA6 HAND1 ISL1 MESP1 NKX2-5
47 positive regulation of transcription, DNA-templated GO:0045893 10.02 GATA4 GATA6 HAND1 MESP1 NKX2-5 TBX1
48 positive regulation of transcription by RNA polymerase II GO:0045944 10 GATA4 GATA6 HAND1 ISL1 MESP1 MOSPD1

Molecular functions related to Double Outlet Right Ventricle according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.85 GATA4 GATA6 HAND1 NKX2-5 ZFPM2
2 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.83 ISL1 MESP1 NKX2-5 TBX20 ZIC3
3 transcription regulatory region DNA binding GO:0044212 9.77 GATA4 GATA6 HAND1 MESP1 NKX2-5
4 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.7 GATA6 HAND1 ISL1 MESP1 NKX2-5 TBX20
5 RNA polymerase II transcription factor binding GO:0001085 9.62 GATA4 GATA6 TBX20 ZFPM2
6 sequence-specific DNA binding GO:0043565 9.61 GATA4 GATA6 HAND1 ISL1 NKX2-5 NKX2-6
7 bHLH transcription factor binding GO:0043425 9.49 HAND1 ISL1
8 enhancer sequence-specific DNA binding GO:0001158 9.48 GATA4 ISL1
9 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.4 GATA4 GATA6 HAND1 ISL1 MESP1 NKX2-5
10 DNA binding GO:0003677 10.03 GATA4 GATA6 HAND1 ISL1 MESP1 NKX2-5
11 DNA binding transcription factor activity GO:0003700 10.01 GATA4 GATA6 MESP1 NKX2-5 NKX2-6 TBX1

Sources for Double Outlet Right Ventricle

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....