GWD
MCID: DRC001
MIFTS: 36

Dracunculiasis (GWD)

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Dracunculiasis

MalaCards integrated aliases for Dracunculiasis:

Name: Dracunculiasis 12 73 20 58 3 44 15 17 70 32
Guinea Worm Disease 20 58 3
Parasitic Infection Caused by Dracunculus Medinensis 20
Infection by Dracunculus Medinensis 12
Guinea Worm Infection 20
Medina Worm Disease 58
Dracunculosis 58
Dracontiasis 12
Medinensis 58
Gwd 20

Characteristics:

Orphanet epidemiological data:

58
dracunculiasis
Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14418
ICD9CM 34 125.7
MeSH 44 D004320
NCIt 50 C84677
SNOMED-CT 67 48874008
ICD10 32 B72
MESH via Orphanet 45 D004320
ICD10 via Orphanet 33 B72
UMLS via Orphanet 71 C0013100
Orphanet 58 ORPHA231
UMLS 70 C0013100

Summaries for Dracunculiasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode Dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. The female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. The worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection.

MalaCards based summary : Dracunculiasis, also known as guinea worm disease, is related to variola major and smallpox. An important gene associated with Dracunculiasis is TXNL1 (Thioredoxin Like 1). Affiliated tissues include eye, spinal cord and skin, and related phenotypes are nausea and vomiting and skin ulcer

CDC : 3 Guinea worm disease, a Neglected Tropical Disease (NTD), is caused by the parasite Dracunculus medinensis. The disease affects poor communities in remote parts of Africa that do not have safe water to drink. There is neither a drug treatment for Guinea worm disease nor a vaccine to prevent it. Great progress has been made towards elimination of Guinea worm disease; the number of human cases annually has fallen from 3.5 million in the mid-1980s to 28 in 2018.

Wikipedia : 73 Dracunculiasis, also called Guinea-worm disease (GWD), is a parasitic infection by the Guinea worm. A... more...

Related Diseases for Dracunculiasis

Diseases related to Dracunculiasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 variola major 10.3
2 smallpox 10.3
3 schistosoma mansoni infection, susceptibility/ 10.2
4 schistosomiasis 10.2
5 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.1
6 onchocerciasis 10.1
7 volvulus of midgut 10.1
8 filariasis 10.1
9 paraplegia 10.0
10 hypereosinophilic syndrome 10.0
11 urinary tract obstruction 10.0
12 tetanus 10.0
13 ascaris lumbricoides infection 10.0
14 trachoma 10.0
15 filarial elephantiasis 10.0
16 ascaridiasis 10.0
17 poliomyelitis 10.0
18 yaws 10.0
19 elephantiasis 10.0
20 pediculus humanus corporis infestation 9.9 PPP1R14A MT-CO1
21 hypoascorbemia 9.9
22 tungiasis 9.9
23 epidural abscess 9.9
24 typhoid fever 9.9
25 yellow fever 9.9
26 bartonellosis 9.9 PPP1R14A MT-CO1
27 pleurisy 9.9
28 endomyocardial fibrosis 9.9
29 cytokine deficiency 9.9
30 yemenite deaf-blind hypopigmentation syndrome 9.9
31 cysticercosis 9.9
32 sparganosis 9.9
33 constrictive pericarditis 9.9
34 leiomyoma 9.9
35 echinococcosis 9.9
36 pericarditis 9.9
37 cellulitis 9.9
38 skin disease 9.9
39 burkitt lymphoma 9.8
40 sacral agenesis with vertebral anomalies 9.8
41 disease by infectious agent 9.8
42 benign teratoma 9.8
43 bacterial infectious disease 9.8
44 strongyloidiasis 9.8
45 trichuriasis 9.8
46 diarrhea 9.8
47 loiasis 9.8
48 cystic teratoma 9.8
49 mature teratoma 9.8
50 muscular atrophy 9.8

Graphical network of the top 20 diseases related to Dracunculiasis:



Diseases related to Dracunculiasis

Symptoms & Phenotypes for Dracunculiasis

Human phenotypes related to Dracunculiasis:

58 31 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 nausea and vomiting 58 31 hallmark (90%) Very frequent (99-80%) HP:0002017
2 skin ulcer 58 31 hallmark (90%) Very frequent (99-80%) HP:0200042
3 subcutaneous nodule 58 31 hallmark (90%) Very frequent (99-80%) HP:0001482
4 skin rash 58 31 hallmark (90%) Very frequent (99-80%) HP:0000988
5 pruritus 58 31 hallmark (90%) Very frequent (99-80%) HP:0000989
6 abnormal blistering of the skin 58 31 hallmark (90%) Very frequent (99-80%) HP:0008066
7 diarrhea 58 31 hallmark (90%) Very frequent (99-80%) HP:0002014
8 low-grade fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0011134
9 arthritis 58 31 frequent (33%) Frequent (79-30%) HP:0001369
10 cellulitis 58 31 frequent (33%) Frequent (79-30%) HP:0100658
11 recurrent cutaneous abscess formation 58 31 frequent (33%) Frequent (79-30%) HP:0100838
12 limitation of joint mobility 58 31 frequent (33%) Frequent (79-30%) HP:0001376
13 immunologic hypersensitivity 58 31 frequent (33%) Frequent (79-30%) HP:0100326
14 flexion contracture 58 31 occasional (7.5%) Occasional (29-5%) HP:0001371
15 gangrene 58 31 occasional (7.5%) Occasional (29-5%) HP:0100758

GenomeRNAi Phenotypes related to Dracunculiasis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.1 RPE
2 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.1 RPE SP2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.1 RPE
4 Increased shRNA abundance (Z-score > 2) GR00366-A-51 9.1 SP2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.1 RPE

Drugs & Therapeutics for Dracunculiasis

Search Clinical Trials , NIH Clinical Center for Dracunculiasis

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Thiabendazole

Cochrane evidence based reviews: dracunculiasis

Genetic Tests for Dracunculiasis

Anatomical Context for Dracunculiasis

MalaCards organs/tissues related to Dracunculiasis:

40
Eye, Spinal Cord, Skin

Publications for Dracunculiasis

Articles related to Dracunculiasis:

(show top 50) (show all 542)
# Title Authors PMID Year
1
Dracunculiasis in a domestic dog in Brazil. 61
33624148 2021
2
A mathematical model of Guinea worm disease in Chad with fish as intermediate transport hosts. 61
33744311 2021
3
Dracunculiasis X in Vietnam: Emerging public health threat or exotic gem? 61
33610782 2021
4
Lessons learned for surveillance strategies for trachoma elimination as a public health problem, from the evaluation of approaches utilised by Guinea worm and onchocerciasis programmes: A literature review. 61
33507903 2021
5
Parasitosis of the vertebral canal mimicking lumbar intervertebral disc herniation: a case report. 61
33402141 2021
6
Development of a Multiplex Bead Assay for the Detection of Canine IgG4 Antibody Responses to Guinea Worm. 61
33124546 2021
7
Challenges in the last mile of the global guinea worm eradication program. 61
32946140 2020
8
Investigation of Dracunculiasis Transmission among Humans, Chad, 2013-2017. 61
33289475 2020
9
Development of a Multiplex Bead Assay for the Detection of IgG Antibody Responses to Guinea Worm. 61
32901602 2020
10
Agent-Based Simulation for Seasonal Guinea Worm Disease in Chad Dogs. 61
32901603 2020
11
Setback for campaign to eradicate Guinea worm disease. 61
33188099 2020
12
Progress Toward Global Eradication of Dracunculiasis, January 2019-June 2020. 61
33119555 2020
13
A One Health Approach for Guinea Worm Disease Control: Scope and Opportunities. 61
33066254 2020
14
Identifying correlates of Guinea worm (Dracunculus medinensis) infection in domestic dog populations. 61
32925916 2020
15
Prevalence and pattern of waterborne parasitic infections in eastern Africa: A systematic scoping review. 61
32995583 2020
16
Ecology of domestic dogs (Canis familiaris) as a host for Guinea worm (Dracunculus medinensis) infection in Ethiopia. 61
32615005 2020
17
Cooking copepods: The survival of cyclopoid copepods (Crustacea: Copepoda) in simulated provisioned water containers and implications for the Guinea Worm Eradication Program in Chad, Africa. 61
32173575 2020
18
Guinea worm in domestic dogs in Chad: A description and analysis of surveillance data. 61
32463811 2020
19
Ecology of domestic dogs Canis familiaris as an emerging reservoir of Guinea worm Dracunculus medinensis infection. 61
32310976 2020
20
Dogs and the classic route of Guinea Worm transmission: an evaluation of copepod ingestion. 61
31996759 2020
21
Erratum: Vol. 68, No. 43. 61
31774742 2019
22
Progress Toward Global Eradication of Dracunculiasis - January 2018-June 2019. 61
31671082 2019
23
Dracunculiasis-a case study for infection eradication. 61
31657767 2019
24
Dracunculiasis: water-borne anthroponosis vs. food-borne zoonosis. 61
31434586 2019
25
Guinea worm disease eradication: a moving target. 61
30938302 2019
26
Guinea-worm (Dracunculus medinensis) infection presenting as a diabetic foot abscess: A case report from Kerala. 61
31823935 2019
27
Achieving the endgame: Integrated NTD case searches. 61
30571758 2018
28
A mathematical study to control Guinea worm disease: a case study on Chad. 61
30325272 2018
29
Progress Toward Global Eradication of Dracunculiasis - January 2017-June 2018. 61
30439874 2018
30
Population genetic analysis of Chadian Guinea worms reveals that human and non-human hosts share common parasite populations. 61
30286084 2018
31
Dracunculiasis Eradication: Are We There Yet? 61
29869608 2018
32
New challenges to eradicating Guinea worm disease. 61
30064676 2018
33
Why Funding for Neglected Tropical Diseases Should Be a Global Priority. 61
29688342 2018
34
Slaying little dragons: the impact of the Guinea Worm Eradication Program on dracunculiasis disability averted from 1990 to 2016. 61
30234196 2018
35
What It Means to Be Guinea Worm Free: An Insider's Account from Ghana's Northern Region. 61
29557333 2018
36
African Countries Move Closer to Eradicating Guinea Worm Disease. 61
29362803 2018
37
Human Parasitology and Parasitic Diseases: Heading Towards 2050. 61
29753341 2018
38
Progress Toward Global Eradication of Dracunculiasis, January 2016-June 2017. 61
29216028 2017
39
WHO delays guinea-worm disease eradication to 2020: are dogs the sole culprits? 61
29115265 2017
40
Patent landscape of neglected tropical diseases: an analysis of worldwide patent families. 61
29137663 2017
41
Heterogeneity in schistosomiasis transmission dynamics. 61
28823529 2017
42
The Golden Age of parasitology-1875-1925: the Scottish contributions. 61
27628769 2017
43
Glasgow encounters with tropical diseases. 61
28673370 2017
44
Guinea worm: from Robert Leiper to eradication. 61
28653590 2017
45
The cost-effectiveness of an eradication programme in the end game: Evidence from guinea worm disease. 61
28981510 2017
46
Recurrence of Guinea Worm Disease in Chad after a 10-Year Absence: Risk Factors for Human Cases Identified in 2010-2011. 61
28722616 2017
47
Dracunculiasis eradication: global surveillance summary, 2016. 61
28530374 2017
48
The painting of St. Roch in the picture gallery of Bari (15th century): An ancient representation of dracunculiasis? 61
28189713 2017
49
Zero Cases of Guinea Worm Disease in Mali. 61
28324099 2017
50
Unexpected hosts: imaging parasitic diseases. 61
27882478 2017

Variations for Dracunculiasis

Expression for Dracunculiasis

Search GEO for disease gene expression data for Dracunculiasis.

Pathways for Dracunculiasis

GO Terms for Dracunculiasis

Sources for Dracunculiasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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