MCID: DRG024
MIFTS: 40

Drug Allergy

Categories: Immune diseases

Aliases & Classifications for Drug Allergy

MalaCards integrated aliases for Drug Allergy:

Name: Drug Allergy 12 15 17
Drug Allergies 62
Allergy Drug 54

Classifications:



External Ids:

Disease Ontology 12 DOID:0060500

Summaries for Drug Allergy

Disease Ontology : 12 An allergic disease that is triggered by a drug.

MalaCards based summary : Drug Allergy, also known as drug allergies, is related to carbapenem allergy and oxirane allergy. An important gene associated with Drug Allergy is TPT1 (Tumor Protein, Translationally-Controlled 1), and among its related pathways/superpathways are Innate Lymphoid Cell Differentiation Pathways and IL4-mediated signaling events. The drugs Amoxicillin and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and lung, and related phenotype is digestive/alimentary.

Wikipedia : 73 A drug allergy is an allergy to a drug, most commonly a medication, and is a form of adverse drug... more...

Related Diseases for Drug Allergy

Diseases related to Drug Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 631)
# Related Disease Score Top Affiliating Genes
1 carbapenem allergy 31.8 IL13 ENPP3
2 oxirane allergy 31.8 ENPP3 CD63 ALB
3 cephalosporin allergy 31.6 MRGPRX2 ENPP3
4 chlorhexidine allergy 31.6 ENPP3 CD63 ACE
5 beta-lactam allergy 31.6 IL4R IL13 IGHE ENPP3
6 diclofenac allergy 31.3 ENPP3 CD63 ATP4A ATP12A ALB
7 allergic disease 31.0 IL5 IL4R IL13 IGHE
8 penicillin allergy 30.7 IL4R IL13 IGHE
9 angioedema 30.3 IL5 IGHE CRP ACE
10 ige responsiveness, atopic 30.3 IL5 IL4R IL13 IGHE
11 amoxicillin allergy 30.2 IGHE ENPP3 CD63
12 latex allergy 30.1 IL5 IL13 IGHE
13 peanut allergy 30.0 IL5 IL13 IGHE
14 conjunctivitis 29.8 IL5 IL13 IGHE
15 dermatitis 29.7 IL5 IL4R IL13 IGHE CD4
16 rhinitis 29.7 TPT1 IL5 IL4R IL13 IGHE CYP3A4
17 bronchitis 29.7 IL5 IL13 CRP ALB
18 food allergy 29.6 TPT1 IL5 IL4R IL13 IGHE ENPP3
19 active peptic ulcer disease 29.6 CRP ATP4A ATP12A ALB
20 otitis media 29.6 IL5 IGHE CRP ALB
21 allergic rhinitis 29.5 TPT1 IL5 IL4R IL13 IGHE
22 chorioretinitis 29.5 CRP CD4 ACE
23 iridocyclitis 29.5 CRP CD4 ACE
24 interstitial lung disease 29.4 IL5 IL13 CRP ALB
25 anxiety 29.4 INS CYP3A4 CRP ACE
26 pulmonary edema 29.4 IL13 CRP ACE
27 pancytopenia 29.2 TPMT CRP CD4 ACE
28 pneumonia 29.2 IL5 IL13 CRP ALB ACE
29 cystic fibrosis 29.2 INS IL5 IL13 CRP CD4 ALB
30 exanthem 29.1 GPT CYP3A4 CRP CD4 ATP4A ATP12A
31 asthma 29.1 TPT1 INS IL5 IL4R IL13 IGHE
32 inherited metabolic disorder 29.0 INS GPT CRP ALB ACE
33 dermatitis, atopic 29.0 TPMT IL5 IL4R IL13 IGHE CD4
34 severe cutaneous adverse reaction 29.0 TPMT MRGPRX2 GPT CYP3A4 CRP CD4
35 nephrotic syndrome 28.9 IL4R IL13 CRP ALB ACE
36 skin disease 28.8 INS IL5 IL13 CRP CD4 ALB
37 dysentery 28.8 GPT CRP CD4 ATP4A ATP12A ALB
38 syphilis 28.8 GPT CRP CD4 ALB ACE
39 lung disease 28.8 INS IL5 IL13 CRP ALB ACE
40 body mass index quantitative trait locus 11 28.4 INS GPT CYP3A4 CRP CD4 ALB
41 inflammatory bowel disease 28.3 TPMT IL5 IL4R IL13 CRP ALB
42 urticaria 28.3 TPT1 MRGPRX2 IL5 IL13 IGHE ENPP3
43 systemic lupus erythematosus 28.2 INS IL5 IL13 CRP CD4 ALB
44 chronic urticaria 28.2 TPT1 MRGPRX2 IL13 IGHE ENPP3 CRP
45 respiratory failure 28.2 IL5 IL13 GPT CRP CD4 ALB
46 sulfonamide allergy 11.0
47 aspirin allergy 11.0
48 carbamazepine allergy 11.0
49 abacavir allergy 11.0
50 isoniazide allergy 11.0

Graphical network of the top 20 diseases related to Drug Allergy:



Diseases related to Drug Allergy

Symptoms & Phenotypes for Drug Allergy

MGI Mouse Phenotypes related to Drug Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.32 ALB ATP12A ATP4A CD4 CD63 ENPP3

Drugs & Therapeutics for Drug Allergy

Drugs for Drug Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
2
Metronidazole Approved Phase 4 443-48-1 4173
3 Anti-Bacterial Agents Phase 4
4 Antibiotics, Antitubercular Phase 4
5 Anti-Infective Agents Phase 4
6 Cephalosporins Phase 4
7 Antitubercular Agents Phase 4
8
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
9
Ketotifen Approved Phase 3 34580-13-7, 34580-14-8 3827
10 Anti-Allergic Agents Phase 3
11 Neurotransmitter Agents Phase 3
12 Histamine Antagonists Phase 3
13
Histamine Phosphate Phase 3 51-74-1 65513
14 Histamine H1 Antagonists Phase 3
15 Dermatologic Agents Phase 3
16
Omalizumab Approved, Investigational Phase 1 242138-07-4
17 Respiratory System Agents Phase 1
18 Anti-Asthmatic Agents Phase 1
19
Cetirizine Approved 83881-51-0 2678
20
Ephedrine Approved 299-42-3 9294
21
Pseudoephedrine Approved 90-82-4 7028
22
Clindamycin Approved, Vet_approved 18323-44-9 29029
23
Quinine Approved 130-95-0 8549 3034034
24
Piperaquine Approved, Experimental, Investigational 4085-31-8 5079497
25 Anesthetics
26 Central Nervous System Stimulants
27 Nasal Decongestants
28 Adrenergic Agents
29 Histamine H1 Antagonists, Non-Sedating
30 Sympathomimetics
31 Bronchodilator Agents
32 Vasoconstrictor Agents
33 Red Cinchona
34 Antiparasitic Agents
35 Antiprotozoal Agents
36 Clindamycin phosphate
37 Clindamycin palmitate
38 Antimalarials
39 penicillins
40 beta-Lactams
41 Lactams

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Partial Oral Antibiotic Treatment for Bacterial Brain Abscess: An Open-label Randomised Non-inferiority Trial Recruiting NCT04140903 Phase 4 Early transition to oral antibiotics;Standard treatment of intravenous antibiotics
2 Improving Safety by Basic Computerizing Outpatient Prescribing Completed NCT01091038 Phase 2, Phase 3
3 A Multi-Center, Randomized, Double-Masked, Placebo-Controlled Evaluation of the Efficacy and Safety of an Anti-Allergy Drug With a Contact Lens as Compared to Placebo in the Prevention of Allergic Conjunctivitis in a Population of Allergic Contact Lens Wearers Completed NCT00445874 Phase 3 Ketotifen with a Contact Lens (no generic name)
4 A Multi-Center, Randomized, Double-Masked, Placebo-Controlled Evaluation of the Efficacy and Safety of an Anti-Allergy Drug With a Contact Lens as Compared to Placebo in the Prevention of Allergic Conjunctivitis in a Population of Allergic Contact Lens Wearers Completed NCT00432757 Phase 3 Ketotifen with a Contact Lens (generic name not yet established)
5 A Multi-Center, Randomized, Double-Masked, Placebo-Controlled, Parallel-Group Study Evaluating the Safety of a Novel Contact Lens Used Daily in Healthy, Normal Volunteers Completed NCT00569777 Phase 3
6 Study of Omalizumab as Adjuvant Therapy in Chemotherapy Desensitization Completed NCT02118987 Phase 1 Omalizumab
7 The Multicenter Registry of Patients With Severe Cutaneous Adverse Reactions Among Tertiary Medical Institutes in Thailand Unknown status NCT02574988
8 The Clinical Study on Pseudo-allergic Reaction to Anesthetic Drugs During General Anesthesia Unknown status NCT03157180
9 Improved Basophil Activation Test (BAT) in the Diagnostics of IgE-mediated Drug Allergy Unknown status NCT03164044
10 The Optimized Diagnostic Methods for the Confirmation of Beta-lactam Hypersensitivity in Thailand Completed NCT01667055
11 Multiple Drug Hypersensitivity Syndrome in a Large Database Completed NCT03784482
12 Quality of Life of Patients With a History of Drug Allergy in Thailand Completed NCT01666470
13 Designing Predictive Models for Betalactam Allergy Using the Drug Allergy and Hypersensitivity Database® Completed NCT03076749
14 An Investigation to Evaluate the Technique of MRI as an Assessment of the Effect of Anti-allergy Drug Treatment on Internal Nasal and Sinus Mucosal Anatomy Following Intranasal Allergen Challenge in Subjects With Seasonal Allergic Rhinitis. Completed NCT00517946 pseudoephedrine hydrochloride;cetirizine hydrochloride
15 Compact Biophotonic Platform for Drug Allergy Diagnosis Recruiting NCT02839811
16 Operational Evaluation of Mass Screening and Treatment Using Ultrasensitive Rapid Detection Tests to Reduce P. Falciparum Incidence in a Malaria Elimination Program in Eastern Kayin State, Myanmar Recruiting NCT04093765 Antimalarials
17 Diagnostic De-labeling of Patients With False Diagnosis of Penicillin Allergy: A Tool for Improving Antimicrobial Treatment and Reducing Antimicrobial Resistance Recruiting NCT03581604
18 Drug Allergy Labels in Different Electronic Health Records After Drug Allergy Investigation Not yet recruiting NCT04827602
19 Safety and Efficacy of an Oral Penicillin Challenge in Low Risk Hospitalized Patients Not yet recruiting NCT04408508 Amoxicillin 250 MG

Search NIH Clinical Center for Drug Allergy

Genetic Tests for Drug Allergy

Anatomical Context for Drug Allergy

MalaCards organs/tissues related to Drug Allergy:

40
Skin, Heart, Lung, Liver, Kidney, Bone, T Cells

Publications for Drug Allergy

Articles related to Drug Allergy:

(show top 50) (show all 2217)
# Title Authors PMID Year
1
Drug-specific in vitro release of IL-2, IL-5, IL-13 and IFN-gamma in patients with delayed-type drug hypersensitivity. 54 61
19254289 2009
2
Pharmacogenetic determinants of immediate and delayed reactions of drug hypersensitivity. 54 61
18991696 2008
3
Detection of serum histamine-releasing factors in a patient with idiopathic anaphylaxis and multiple drug allergy syndrome. 61 54
17460952 2007
4
[Pharmacogenetics: Important aspects for dermatology]. 54 61
15645192 2005
5
Sera from patients with multiple drug allergy syndrome contain circulating histamine-releasing factors. 54 61
12876410 2003
6
The role of immunoglobulin E in allergy and asthma. 61 54
11704610 2001
7
In vitro drug allergy detection system incorporating human liver microsomes in chlorazepate-induced skin rash: drug-specific proliferation associated with interleukin-5 secretion. 61 54
11251565 2001
8
Distinct serum cytokine levels in drug- and measles-induced exanthema. 61 54
10592468 1999
9
Humanization of a mouse anti-human IgE antibody: a potential therapeutic for IgE-mediated allergies. 61 54
8309946 1993
10
[The determination of specific IgE in allergy diagnosis. The clinical significance of specific IgE in drug allergies]. 61 54
2151433 1990
11
Reported drug allergies among patients with opioid use disorder: Role for allergy evaluation and intervention. 61
33387617 2021
12
Obesity markers in patients with drug allergy and body fat as a predictor. 61
33771681 2021
13
Health Disparities in Allergic and Immunologic Conditions in Racial and Ethnic Underserved Populations: A Work Group Report of the AAAAI Committee on the Underserved. 61
33713767 2021
14
Methimazole Drug Allergy: A Possible Solution Using a "Methimazole Solution". 61
33645515 2021
15
Editorial - Special Issue on in vitro detection of drug allergy. 61
33684438 2021
16
Excipient Hypersensitivity masquerading as Multi Drug Allergy. 61
33811872 2021
17
Single-dose prolonged drug provocation test, without previous skin testing, is safe for diagnosing children with mild non-immediate reactions to beta-lactams. 61
33650109 2021
18
Spanish Society vision of Drug challenge tests. 61
33653682 2021
19
Lymphocyte transformation test: History and current approaches. 61
33745950 2021
20
Economic impact of pharmacist interventions in pediatric ambulatory care clinics. 61
33358098 2021
21
Severe cutaneous adverse drug reactions: diagnostic approach and genetic study in a Brazilian case series. 61
33728835 2021
22
Antibiotics dispensing practice in community pharmacies: results of a cross sectional study in Italy. 61
33781998 2021
23
Triflusal in Patients with Acute Coronary Syndrome and Acetylsalicylic Acid Hypersensitivity. 61
33756460 2021
24
PEG That Reaction: A Case Series of Allergy to Polyethylene Glycol. 61
33543766 2021
25
Drug hypersensitivity in children: a retrospective analysis of 101 pharmacovigilance reports. 61
33155108 2021
26
Descriptive analysis of a simplified approach to low-risk drug hypersensitivity reactions. 61
32896639 2021
27
Drug allergy to CFTR modulator therapy associated with lumacaftor-specific CD4+ T lymphocytes. 61
32526307 2021
28
Drug Allergy Labels Lost in Translation: From Patient to Charts and Backwards. 61
33607342 2021
29
Safety, Efficacy, and Effectiveness of Delabeling in Patients with Multiple Drug Allergy Labels. 61
32966878 2021
30
Polyethylene Glycol-Induced Systemic Allergic Reactions (Anaphylaxis). 61
33011299 2021
31
Severe liver injury associated with glecaprevir plus pibrentasvir therapy in a patient with treatment-naïve hepatitis C virus infection. 61
33612683 2021
32
Skin eruptions in children: Drug hypersensitivity vs viral exanthema. 61
33621365 2021
33
Safety and efficacy of edaravone for patients with acute stroke: A protocol for randomized clinical trial. 61
33663100 2021
34
Breastfeeding duration modified the effects of neonatal and familial risk factors on childhood asthma and allergy: a population-based study. 61
33549112 2021
35
Association of Maternal History of Allergic Features with Preterm Pregnancy Outcomes in the Japan Environment and Children's Study. 61
33601376 2021
36
Vancomycin Hypersensitivity Reactions Documented in Electronic Health Records. 61
33011300 2021
37
Management of Allergic Diseases During COVID-19 Outbreak. 61
33560451 2021
38
Current Perspective Regarding the Immunopathogenesis of Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms (DIHS/DRESS). 61
33670052 2021
39
Clinical characteristics of 182 pediatric COVID-19 patients with different severities and allergic status. 61
32524611 2021
40
Immune-related cutaneous adverse events due to checkpoint inhibitors. 61
33609771 2021
41
Refractoriness to drugs in migraine may be the result of developing anti-drug antibodies. 61
33360448 2021
42
Maternal known drug allergy and long-term neurological hospitalizations of the offspring. 61
32869378 2021
43
Descriptive Analysis of Cross-Reactive Anaphylaxis as a Different Clinical Subtype of Nonsteroidal Anti-Inflammatory Drug (NSAID) Hypersensitivity. 61
32957109 2021
44
Cutaneous eruption in COVID-19-infected patients in Thailand: An observational descriptive study. 61
33180327 2021
45
Documentation of Adverse Drug Reactions to Opioids in an Electronic Health Record. 61
33465262 2021
46
[MANAGEMENT OF DRUG ALLERGY-AN UPDATE]. 61
33692277 2021
47
Maternal known drug allergy and long-term dermatological morbidity of the offspring. 61
33025676 2021
48
Relational professional identity: How do pharmacy students see themselves in relation to others? 61
33598058 2021
49
Factors Associated with Self-Reported Drug Allergies in a Large Chronic Spontaneous Urticaria Cohort. 61
33006537 2021
50
Synchronous Telemedicine in Allergy: Lessons Learned and Transformation of Care During the COVID-19 Pandemic. 61
33091636 2021

Variations for Drug Allergy

Expression for Drug Allergy

Search GEO for disease gene expression data for Drug Allergy.

Pathways for Drug Allergy

GO Terms for Drug Allergy

Cellular components related to Drug Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 INS IL5 IL4R IL13 IGHE ENPP3
2 external side of plasma membrane GO:0009897 9.55 IL13 IGHE ENPP3 CD4 ACE
3 extracellular space GO:0005615 9.36 TPT1 INS IL5 IL4R IL13 GPT

Biological processes related to Drug Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.72 IL5 IL4R IL13 IGHE CD4
2 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.37 ATP4A ATP12A
3 cytokine-mediated signaling pathway GO:0019221 9.35 IL5 IL4R IL13 IGHE CD4
4 positive regulation of mast cell degranulation GO:0043306 9.26 IL4R IL13
5 negative regulation of NAD(P)H oxidase activity GO:0033861 9.16 INS IL13
6 positive regulation of immunoglobulin production GO:0002639 8.8 IL5 IL4R IL13

Molecular functions related to Drug Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Drug Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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