MCID: DRG024
MIFTS: 43

Drug Allergy

Categories: Immune diseases

Aliases & Classifications for Drug Allergy

MalaCards integrated aliases for Drug Allergy:

Name: Drug Allergy 12 15 17
Drug Allergies 62
Allergy Drug 54

Classifications:



External Ids:

Disease Ontology 12 DOID:0060500

Summaries for Drug Allergy

Disease Ontology : 12 A hypersensitivity reaction type I disease triggered by a drug.

MalaCards based summary : Drug Allergy, also known as drug allergies, is related to oxirane allergy and beta-lactam allergy. An important gene associated with Drug Allergy is TPT1 (Tumor Protein, Translationally-Controlled 1), and among its related pathways/superpathways are Folate Metabolism and B Cell Development Pathways. The drugs Morphine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and liver, and related phenotypes are Decreased HIV-LTR-beta-galactosidase protein expression and homeostasis/metabolism

Wikipedia : 74 A drug allergy is an allergy to a drug, most commonly a medication, and is a form of adverse drug... more...

Related Diseases for Drug Allergy

Diseases related to Drug Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 665)
# Related Disease Score Top Affiliating Genes
1 oxirane allergy 32.0 ENPP3 CD63 ALB
2 beta-lactam allergy 32.0 KAT8 IL4R IGHE ENPP3
3 corticosteroid allergy 31.9 IL5 CD4 ALB
4 diclofenac allergy 31.4 ENPP3 CD63 ATP4A ATP12A ALB
5 ige responsiveness, atopic 30.9 IL5 IL4R IGHE
6 allergic hypersensitivity disease 30.8 TPT1 IL5 IL4R IGHE ENPP3 CD4
7 amoxicillin allergy 30.4 IGHE ENPP3 CD63
8 penicillin allergy 30.3 KAT8 IL4R IGHE ATP12A
9 urticaria 30.2 TPT1 IL5 IGHE ENPP3 CRP CD40LG
10 allergic rhinitis 30.2 TPT1 IL5 IL4R IGHE
11 atopic keratoconjunctivitis 30.2 IL5 IGHE
12 food allergy 30.1 TPT1 IL5 IL4R IGHE ENPP3 ALB
13 peptic ulcer disease 30.0 ATP4A ATP12A ALB
14 pollen allergy 30.0 IL5 IL4R ENPP3 CD63
15 bullous skin disease 29.9 IL5 CD40LG CD4
16 egg allergy 29.9 IL5 IGHE ENPP3 CD63
17 angioedema 29.9 IL5 IGHE CRP CD40LG ACE
18 rhinitis 29.8 TPT1 IL5 IL4R IGHE CYP3A4 ALB
19 severe acute respiratory syndrome 29.6 GPT CRP CD40LG
20 autoimmune disease 29.5 TPMT INS IL5 CRP CD40LG
21 bronchitis 29.4 IL5 IGHE CRP CD40LG ALB
22 interstitial lung disease 29.4 IL5 CRP CD40LG ALB
23 chorioretinitis 29.4 CD40LG CD4 ACE
24 acquired immunodeficiency syndrome 29.4 IL4R CRP CD40LG CD4 ALB
25 congestive heart failure 29.4 INS CRP ALB ACE
26 otitis media 29.2 IL5 IGHE CRP CD40LG ALB
27 diarrhea 29.2 IL5 GPT CYP3A4 CD40LG ALB
28 skin disease 29.2 IL5 CRP CD40LG CD4 ALB
29 acute kidney failure 29.1 GPT F2 ALB
30 iridocyclitis 29.1 CRP CD40LG CD4 ACE
31 collagen disease 29.1 CRP CD40LG CD4 ACE
32 severe cutaneous adverse reaction 29.0 TPMT GPT CYP3A4 CRP CD40LG CD4
33 pulmonary edema 28.8 F2 CRP ACE
34 pancytopenia 28.8 TPMT CRP CD40LG CD4 ACE
35 liver disease 28.8 INS GPT F2 CYP3A4 ALB
36 active peptic ulcer disease 28.7 F2 CRP ATP4A ATP12A ALB
37 lung disease 28.7 INS IL5 CRP CD40LG ALB ACE
38 dysentery 28.7 CRP CD40LG CD4 ATP4A ATP12A ALB
39 thrombocytopenia 28.7 GPT F2 CRP CD40LG ALB
40 purpura 28.6 F2 CRP CD40LG ACE
41 connective tissue disease 28.5 INS CRP CD40LG CD4 ALB ACE
42 dermatitis, atopic 28.3 TPMT IL5 IL4R IGHE ENPP3 CD63
43 inherited metabolic disorder 28.1 INS GPT F2 CRP ALB ACE
44 asthma 28.1 TPT1 INS IL5 IL4R IGHE F2
45 syphilis 28.0 IGHE GPT CRP CD40LG CD4 ALB
46 pneumonia 27.8 IL5 GPT F2 CRP CD40LG ALB
47 systemic lupus erythematosus 27.7 INS IL5 F2 CRP CD40LG CD4
48 inflammatory bowel disease 27.7 TPMT IL5 IL4R F2 CRP CD40LG
49 respiratory failure 27.6 IL5 GPT F2 CRP CD4 ALB
50 exanthem 27.5 GPT F2 CYP3A4 CRP CD40LG CD4

Graphical network of the top 20 diseases related to Drug Allergy:



Diseases related to Drug Allergy

Symptoms & Phenotypes for Drug Allergy

GenomeRNAi Phenotypes related to Drug Allergy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased HIV-LTR-beta-galactosidase protein expression GR00224-A-1 8.92 CD4 CYP3A4 F2 TPT1

MGI Mouse Phenotypes related to Drug Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10 ACE ALB ATP12A ATP4A CD4 CD40LG
2 digestive/alimentary MP:0005381 9.96 ALB ATP12A ATP4A CD4 CD63 ENPP3
3 immune system MP:0005387 9.7 ACE ALB ATP4A CD4 CD40LG CRP
4 mortality/aging MP:0010768 9.44 ACE ALB ATP4A CD4 CD40LG ENPP3

Drugs & Therapeutics for Drug Allergy

Drugs for Drug Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 202)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Morphine Approved, Investigational Phase 4 57-27-2 5288826
2
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
3
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
5
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
6
Orlistat Approved, Investigational Phase 4 96829-58-2 3034010
7
Liraglutide Approved Phase 4 204656-20-2 44147092
8
Empagliflozin Approved Phase 4 864070-44-0
9
Linagliptin Approved Phase 4 668270-12-0 10096344
10
Canagliflozin Approved Phase 4 842133-18-0
11
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
12
Metronidazole Approved Phase 4 443-48-1 4173
13 Analgesics Phase 4
14 Narcotics Phase 4
15 Analgesics, Opioid Phase 4
16 Cathartics Phase 4
17 Viscosupplements Phase 4
18 Adjuvants, Immunologic Phase 4
19 Protective Agents Phase 4
20 Laxatives Phase 4
21 Carboxymethylcellulose Sodium Phase 4
22 Immunologic Factors Phase 4
23 Hormones Phase 4
24 Anti-Inflammatory Agents Phase 4
25 Autonomic Agents Phase 4
26 Antiemetics Phase 4
27 HIV Protease Inhibitors Phase 4
28
protease inhibitors Phase 4
29 Gastrointestinal Agents Phase 4
30 Hormone Antagonists Phase 4
31 BB 1101 Phase 4
32 Antineoplastic Agents, Hormonal Phase 4
33 glucocorticoids Phase 4
34 Incretins Phase 4
35 Anti-Obesity Agents Phase 4
36 Sitagliptin Phosphate Phase 4
37 Sodium-Glucose Transporter 2 Inhibitors Phase 4
38 Dipeptidyl-Peptidase IV Inhibitors Phase 4
39 Hypoglycemic Agents Phase 4
40 Lipid Regulating Agents Phase 4
41 Antibiotics, Antitubercular Phase 4
42 Anti-Bacterial Agents Phase 4
43 Anti-Infective Agents Phase 4
44 Antitubercular Agents Phase 4
45 Cephalosporins Phase 4
46
Cisplatin Approved Phase 2, Phase 3 15663-27-1 84093 441203 2767
47
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
48
Capecitabine Approved, Investigational Phase 2, Phase 3 154361-50-9 60953
49 Ethiodized oil Approved, Investigational Phase 2, Phase 3 8008-53-5
50
Ketotifen Approved Phase 3 34580-13-7, 34580-14-8 3827

Interventional clinical trials:

(show top 50) (show all 76)
# Name Status NCT ID Phase Drugs
1 A Clinical Trial of Danhong Injection in Treating Acute Ischemic Stroke Unknown status NCT02152280 Phase 4 Danhong Injection;Normal Saline
2 Efficacy of Transverses Abdominis -Plane Block With Bupivacaine Versus Bupivacaine With Morphine in Patients Undergoing Major Abdominal Cancer Surgery Completed NCT02566096 Phase 4 transversus abdominis-plane block with local anesthetic 20 ml of bupivacaine 0.5% + 10 mg morphine
3 Basophil Activation Test (BAT) Sensitivity in Child Food Allergy Completed NCT01966640 Phase 4
4 Hyaluronic Acid-Carboxymethylcellulose Reduced Postoperative Bowel Adhesions Following Laparoscopic Urologic Pelvic Surgery: a Prospective, Randomized, Controlled, Single-Blind Study Completed NCT02773251 Phase 4 hyaluronic acid-carboxymethylcellulose
5 Roux-en-Y Gastric Bypass for BMI 27-32 Type 2 Diabetes vs Best Medical Treatment Recruiting NCT02041234 Phase 4 Incretin analogues;Xenical;SGLT2 inhibitors;DPP-4 Inhibitors
6 Comparision of Addition of Dexamethasone vs Bicarbonate to Intracuff Lignocaine 2% in Terms of Extubation Characteristics and Patient Satisfaction Undergoing General Anaesthesia Recruiting NCT03833947 Phase 4 lignocaine+bicarbonate;lignocaine+dexamethasone
7 Partial Oral Antibiotic Treatment for Bacterial Brain Abscess: An Open-label Randomised Non-inferiority Trial Not yet recruiting NCT04140903 Phase 4 Early transition to oral antibiotics;Standard treatment of intravenous antibiotics
8 The Use of Valsartan for the Management of Blood Pressure in Acute Stroke: Affects on Cerebral Blood Flow Withdrawn NCT01400256 Phase 4 Valsartan
9 Randomized Control Trial (RCT) of Transarterial Chemoembolization (TACE) Versus TACE and Oral Drug Therapy in the Treatment of Unresectable Hepatocellular Carcinoma Unknown status NCT00522405 Phase 2, Phase 3
10 Improving Safety by Basic Computerizing Outpatient Prescribing Completed NCT01091038 Phase 2, Phase 3
11 A Multi-Center, Randomized, Double-Masked, Placebo-Controlled Evaluation of the Efficacy and Safety of an Anti-Allergy Drug With a Contact Lens as Compared to Placebo in the Prevention of Allergic Conjunctivitis in a Population of Allergic Contact Lens Wearers Completed NCT00445874 Phase 3 Ketotifen with a Contact Lens (no generic name)
12 A Multi-Center, Randomized, Double-Masked, Placebo-Controlled Evaluation of the Efficacy and Safety of an Anti-Allergy Drug With a Contact Lens as Compared to Placebo in the Prevention of Allergic Conjunctivitis in a Population of Allergic Contact Lens Wearers Completed NCT00432757 Phase 3 Ketotifen with a Contact Lens (generic name not yet established)
13 A Multi-Center, Randomized, Double-Masked, Placebo-Controlled, Parallel-Group Study Evaluating the Safety of a Novel Contact Lens Used Daily in Healthy, Normal Volunteers Completed NCT00569777 Phase 3
14 A Phase III, Randomized, Open-label, Multicenter Study of the Safety and Efficacy of Efavirenz Versus Tenofovir When Administered in Combination With the Abacavir/Lamivudine Fixed-dose Combination Tablet as a Once-daily Regimen in Antiretroviral-naive HIV-1 Infected Subjects. Completed NCT00053638 Phase 3 efavirenz;tenofovir;abacavir/lamivudine
15 Effectiveness of 3 Day Amoxycillin Versus 5 Day co-Trimoxazole in the Treatment of Non-Severe Pneumonia in Children Aged 2- 59 Months of Age: - A Multi-Centric Open Labeled Trial Completed NCT00396526 Phase 3 Oral Co-trimoxazole (8mg/kg/day trimithoprim) twice a day for five days vs. oral amoxycillin (20 mg/kg/day) thrice a day for three days.
16 Efficacy and Safety of Ketamine Added to Local Anesthetic in Modified Pectoral Block for Management of Postoperative Pain in Patients Undergoing Modified Radical Mastectomy Completed NCT02620371 Phase 3
17 Randomized Double Blind Placebo Controlled Trial of Amoxycillin in the Treatment of Non-Severe Pneumonia With Wheeze in Children Aged 2- 59 Months of Age: A Multi-Centric Study Completed NCT00407394 Phase 3 Amoxycillin
18 Efficacy of Chloroquine (CQ) Alone Compared to Concomitant CQ and Primaquine (PQ) for the Treatment of Uncomplicated Plasmodium Vivax Infection Completed NCT02691910 Phase 2, Phase 3 Chloroquine;Primaquine
19 Evaluation of the Effects of Two Types of Fluid in the Recovery From Anaesthesia. Completed NCT01122459 Phase 3
20 Aspirin on CTCs of Advanced Breast and Colorectal Cancer Unknown status NCT02602938 Phase 2 Aspirin
21 Two and Three Dimensional Contrast-Enhanced Ultrasound for Screening of Renal Cell Carcinoma Recurrence Following Cryoablation Completed NCT02440334 Phase 2 Optison
22 Combination of Hydroxyurea and Verapamil for Refractory Meningiomas Completed NCT00706810 Phase 2 Hydroxyurea;Verapamil
23 Efficacy of Dexmedetomidine as an Adjuvant to Local Anesthetic Agent in Scalp Block and Scalp Infiltration to Control Post Craniotomy Pain Completed NCT02866409 Phase 2 Dexmedetomidine;Bupivacaine
24 Evaluation of Obatoclax Mesylate as Therapy for Patients With Systemic Mastocytosis Terminated NCT00918931 Phase 2 Obatoclax Mesylate
25 Study of Omalizumab as Adjuvant Therapy in Chemotherapy Desensitization Completed NCT02118987 Phase 1 Omalizumab
26 Role of Airway Tissue Temperature in Asthma Exacerbation Recruiting NCT02401074 Phase 1
27 Drug Challenges Without Prior Skin Testing Active, not recruiting NCT03158831 Phase 1 Placebo-Controlled Graded Drug Challenge
28 The Clinical Study on Pseudo-allergic Reaction to Anesthetic Drugs During General Anesthesia Unknown status NCT03157180
29 Improved Management Based on Pathophysiology of Drug Hypersensitivity in Childhood Unknown status NCT02031120
30 To Effect and Safety of Continuous Venovenous Hemofiltration (CVVH) Versus Conventional Treatment for Acute Severe Hypernatremia in Critical Ill Patients: A Randomized Clinical Trial Unknown status NCT02449382 Control group
31 Efficacy of Prevention for Postoperative Nausea and Vomiting After Intrathecal Morphine in Cesarean Section: a Randomized Comparison of Metoclopramide or Ondansetron Alone or in the Combination With Dexamethasone. Unknown status NCT00892996 dexamethasone;dexamethasone 5 mg
32 Levels of Serum Resistin in Asthmatics as a Potential Marker of Systemic Inflammation and Disease State. Unknown status NCT00339703
33 Serum Interleukin -21 Level in Patients With Severe Adverse Cutaneous Drug Reaction and Correlation With Disease Severity. Unknown status NCT03166241
34 Effect of Periprosthetic Fracture on Hip Function After Femoral Neck-preserving Total Hip Arthroplasty: a Prospective, Single-center, Self-controlled Trial With 2-year Follow-up Unknown status NCT02981823
35 Digital Navigation Enhances Cervical Pedicle Screw Placement Accuracy and Safety: A Randomized Controlled Trial Unknown status NCT02880839
36 Porous Tantalum Rods Improve the Hip Joint Function of Patients With Avascular Necrosis of the Femoral Head After Femoral Neck Fracture Surgery: a Randomized Controlled Trial Unknown status NCT02877472
37 Supercapsular Percutaneously Assisted Total Hip Approach for the Elderly With Femoral Neck Fractures: a Prospective, Open-label, Randomized, Controlled Clinical Trial Unknown status NCT03134664
38 Cobalt Alloy Pedicle Screw Implantation for Severe Kyphosis Deformity in Spinal Tuberculosis: a Selfcontrolled Trial Unknown status NCT02971644
39 Impact of Clinical Pharmacy Consultations in Patients With Cancer Treated With Oral Anti-cancer Therapies on the Rate of Serious Adverse Events Unknown status NCT02733965
40 Clinical Trial in Assigning of Tacrolimus Dosage Regimen According to CYP3A5 Genotype in Kidney Transplant Recipients Unknown status NCT03173820
41 The Optimized Diagnostic Methods for the Confirmation of Beta-lactam Hypersensitivity in Thailand Completed NCT01667055
42 Extended Open Challenge in Patients With a History of Drug Eruption Following Beta-lactam Treatment Completed NCT01520181 Beta-lactam oral challenge
43 Quality of Life of Patients With a History of Drug Allergy in Thailand Completed NCT01666470
44 Multiple Drug Hypersensitivity Syndrome in a Large Database Completed NCT03784482
45 Immunological and Viral Parameters in Patients Receiving Anti-epileptic Drugs Completed NCT02556320 anti-epileptic drug
46 An Investigation to Evaluate the Technique of MRI as an Assessment of the Effect of Anti-allergy Drug Treatment on Internal Nasal and Sinus Mucosal Anatomy Following Intranasal Allergen Challenge in Subjects With Seasonal Allergic Rhinitis. Completed NCT00517946 pseudoephedrine hydrochloride;cetirizine hydrochloride
47 Designing Predictive Models for Betalactam Allergy Using the Drug Allergy and Hypersensitivity Database® Completed NCT03076749
48 One-time Spray of Epinephrine (1cc) Plus 4% Lidocaine (4cc) is Sufficient Pretreatment Method for the Preparation of Transnasal Endoscopy Completed NCT01708967
49 The Factors Affecting Intentions of Medical Staff to Use Personal Health Record in Northern Hospitals of Taiwan Completed NCT01124084
50 A Randomized Controlled Trial Embedded in an Electronic Medical Record (myHERO). Completed NCT00972348

Search NIH Clinical Center for Drug Allergy

Genetic Tests for Drug Allergy

Anatomical Context for Drug Allergy

MalaCards organs/tissues related to Drug Allergy:

40
Testes, Skin, Liver, T Cells, Heart, Bone, Lung

Publications for Drug Allergy

Articles related to Drug Allergy:

(show top 50) (show all 2077)
# Title Authors PMID Year
1
Drug-specific in vitro release of IL-2, IL-5, IL-13 and IFN-gamma in patients with delayed-type drug hypersensitivity. 54 61
19254289 2009
2
Pharmacogenetic determinants of immediate and delayed reactions of drug hypersensitivity. 54 61
18991696 2008
3
Detection of serum histamine-releasing factors in a patient with idiopathic anaphylaxis and multiple drug allergy syndrome. 54 61
17460952 2007
4
[Pharmacogenetics: Important aspects for dermatology]. 54 61
15645192 2005
5
Sera from patients with multiple drug allergy syndrome contain circulating histamine-releasing factors. 54 61
12876410 2003
6
The role of immunoglobulin E in allergy and asthma. 54 61
11704610 2001
7
In vitro drug allergy detection system incorporating human liver microsomes in chlorazepate-induced skin rash: drug-specific proliferation associated with interleukin-5 secretion. 54 61
11251565 2001
8
Distinct serum cytokine levels in drug- and measles-induced exanthema. 54 61
10592468 1999
9
Humanization of a mouse anti-human IgE antibody: a potential therapeutic for IgE-mediated allergies. 54 61
8309946 1993
10
[The determination of specific IgE in allergy diagnosis. The clinical significance of specific IgE in drug allergies]. 54 61
2151433 1990
11
Pneumocystis jiroveci. 61
32000290 2020
12
Penicillin Allergy in Pregnancy: Moving From "Rash" Decisions to Accurate Diagnosis. 61
31977783 2020
13
Diagnostic confirmation of amoxicillin allergy in children treated at the Division of Pediatric Allergy. 61
31984698 2020
14
Implications of electronic health record transition on drug allergy labels. 61
31351188 2020
15
Drug Allergy in Children: What Should We Know? 61
32024327 2020
16
A novel whole blood based method for lymphocyte transformation test in drug allergies. 61
31958448 2020
17
Physicians prescribe adrenaline autoinjectors, do parents use them when needed? 61
31611040 2020
18
Spanish Guidelines for Diagnosis, Management, Treatment and Prevention of DRESS syndrome. 61
31932268 2020
19
Clinical study of argatroban for preventing vascular thrombosis in the early period after pediatric living-related donor liver transplantation. 61
31944491 2020
20
Multiple Drug Hypersensitivity Syndrome in a Large Database. 61
31238162 2020
21
The patient who reports a drug allergy. 61
31937572 2020
22
Protocols for drug allergy desensitization in children. 61
31771366 2020
23
Epidemiology and drug allergy results in children investigated in allergy unit of a tertiary-care paediatric hospital setting. 61
31924232 2020
24
Drug allergy is associated with the development of extraintestinal manifestations in patients with ulcerative colitis. 61
31594293 2020
25
Aetiopathogenesis of severe cutaneous adverse reactions (SCARs) in children: A 9-year experience in a tertiary care paediatric hospital setting. 61
31608511 2020
26
Enzalutamide and Apalutamide: In Vitro Chemical Reactivity Studies and Activity in a Mouse Drug Allergy Model. 61
31538772 2020
27
The Journal of Allergy and Clinical Immunology: In Practice 2019 Highlights. 61
31980411 2020
28
Drug Hypersensitivity Reactions. 61
31757230 2020
29
Post-marketing safety-related regulatory actions on first-in-class drugs: A double-cohort study. 61
31846100 2019
30
How well is the electronic health record supporting the clinical tasks of hospital physicians? A survey of physicians at three Norwegian hospitals. 61
31801518 2019
31
Perioperative anaphylaxis and investigations: a local study in Hong Kong. 61
31788702 2019
32
Risk factors and prevention for perioperative anaphylaxis: a nested case-control study. 61
31531816 2019
33
Treatment with Tumor Necrosis Factor-α Inhibitors, History of Allergy, and Hypercalcemia Are Risk Factors of Immune Reconstitution Inflammatory Syndrome in HIV-Negative Pulmonary Tuberculosis Patients. 61
31905985 2019
34
The efficacy of perampanel in young children with drug-resistant epilepsy. 61
31901668 2019
35
Longitudinal progression of aspirin-exacerbated respiratory disease: analysis of a national insurance claims database. 61
31442000 2019
36
Drug reactions in children with rheumatic diseases receiving parenteral therapies: 9 years' experience of a tertiary pediatric rheumatology center. 61
31865444 2019
37
Food and drug allergy, and anaphylaxis in EAACI journals (2018). 61
31539176 2019
38
Incidence of teicoplanin adverse drug reactions among patients with vancomycin-associated adverse drug reactions and its risk factors. 61
31722513 2019
39
Should known allergy status be included as a medication administration 'right'? 61
31714835 2019
40
Towards a more precise diagnosis of hypersensitivity to beta-lactams - an EAACI position paper. 61
31749148 2019
41
Treatment practices for aspirin-exacerbated respiratory disease: analysis of a national insurance claims database. 61
31693796 2019
42
Electronic Consultations in Allergy/Immunology. 61
31170540 2019
43
A Multicenter Retrospective Study on Hypersensitivity Reactions to Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) in Children: A Report from the European Network on Drug Allergy (ENDA) Group. 61
31785410 2019
44
Quality of Life in Patients with Allergic Reactions to Medications: Influence of a Drug Allergy Evaluation. 61
31129076 2019
45
Risks and management of antiepileptic drug induced skin reactions in the adult out-patient setting. 61
31708349 2019
46
Drug allergy. 61
31690398 2019
47
Development and validation of the parent-reported Drug Hypersensitivity Quality of Life Questionnaire. 61
31594298 2019
48
Hypersensitivity Reactions to Iodinated Contrast Media: A Multicenter Study of 196 081 Patients. 61
31478801 2019
49
Pediatric Drug Allergies: Updates on Beta-Lactam, Nonsteroidal Anti-Inflammatory Drug, and Chemotherapeutic Reactions. 61
31466678 2019
50
Life Threatening Anaphylaxis With Co-Amoxiclav Despite Having A Previous Tolerant Exposure To The Antibiotic. 61
31965776 2019

Variations for Drug Allergy

Expression for Drug Allergy

Search GEO for disease gene expression data for Drug Allergy.

Pathways for Drug Allergy

Pathways related to Drug Allergy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12 INS F2 CRP ALB
2 11.22 IL4R CD40LG CD4
3 11.1 IL5 IL4R CD4
4 10.98 INS F2 ALB
5 10.72 IL5 IL4R IGHE CD40LG
6 10.65 IL5 IL4R CD40LG

GO Terms for Drug Allergy

Cellular components related to Drug Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.9 INS IL5 IL4R IGHE F2 ENPP3
2 external side of plasma membrane GO:0009897 9.43 IGHE F2 ENPP3 CD40LG CD4 ACE
3 extracellular space GO:0005615 9.4 TPT1 INS IL5 IL4R GPT F2

Biological processes related to Drug Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of blood vessel diameter GO:0097756 9.26 INS CRP
2 negative regulation of protein oligomerization GO:0032460 9.16 INS ALB
3 acute-phase response GO:0006953 9.13 INS F2 CRP
4 immune response GO:0006955 9.1 IL5 IL4R IGHE ENPP3 CD40LG CD4

Molecular functions related to Drug Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Drug Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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