MCID: DRG025
MIFTS: 31

Drug-Induced Hearing Loss

Categories: Ear diseases

Aliases & Classifications for Drug-Induced Hearing Loss

MalaCards integrated aliases for Drug-Induced Hearing Loss:

Name: Drug-Induced Hearing Loss 12 15
Drug Induced Hearing Loss 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0070310

Summaries for Drug-Induced Hearing Loss

Disease Ontology : 12 A nonsyndromic deafness that is characterized by cochlear or vestibular dysfunction resulting in loss of hearing caused by drug ototoxicity.

MalaCards based summary : Drug-Induced Hearing Loss, also known as drug induced hearing loss, is related to ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus and hypotrichosis-deafness syndrome. An important gene associated with Drug-Induced Hearing Loss is PSPN (Persephin), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Spinal Cord Injury. Affiliated tissues include spinal cord and thyroid, and related phenotypes are Decreased influenza A H1N1 (A/WSN/33) virus numbers and behavior/neurological

Related Diseases for Drug-Induced Hearing Loss

Graphical network of the top 20 diseases related to Drug-Induced Hearing Loss:



Diseases related to Drug-Induced Hearing Loss

Symptoms & Phenotypes for Drug-Induced Hearing Loss

GenomeRNAi Phenotypes related to Drug-Induced Hearing Loss according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased influenza A H1N1 (A/WSN/33) virus numbers GR00195-A-2 8.8 ARTN HSPD1 JUN

MGI Mouse Phenotypes related to Drug-Induced Hearing Loss:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.19 BDNF GDNF GFRA1 HMOX1 HSPD1 JUN
2 cellular MP:0005384 10.18 BDNF GDNF GFRA1 GJB2 HMOX1 HSPD1
3 mortality/aging MP:0010768 10.18 BDNF GDNF GFRA1 GJB2 GJB3 HMOX1
4 homeostasis/metabolism MP:0005376 10.14 BDNF GJB2 GJB3 HMOX1 JUN MAPK8
5 nervous system MP:0003631 10.1 ARTN BDNF GDNF GFRA1 GJB2 HSPD1
6 endocrine/exocrine gland MP:0005379 10.03 BDNF GDNF HMOX1 JUN MAPK8 NRTN
7 digestive/alimentary MP:0005381 10 BDNF GDNF GFRA1 MAPK8 NRTN SERPINH1
8 muscle MP:0005369 9.87 GDNF GFRA1 HMOX1 HSPD1 MAPK8 NOX4
9 reproductive system MP:0005389 9.81 BDNF GDNF GJB2 HMOX1 HSPD1 MAPK8
10 respiratory system MP:0005388 9.5 BDNF HMOX1 JUN MAPK8 NOX4 NTRK2
11 vision/eye MP:0005391 9.17 ARTN BDNF GJB2 JUN MAPK8 NRTN

Drugs & Therapeutics for Drug-Induced Hearing Loss

Search Clinical Trials , NIH Clinical Center for Drug-Induced Hearing Loss

Genetic Tests for Drug-Induced Hearing Loss

Anatomical Context for Drug-Induced Hearing Loss

MalaCards organs/tissues related to Drug-Induced Hearing Loss:

41
Spinal Cord, Thyroid

Publications for Drug-Induced Hearing Loss

Articles related to Drug-Induced Hearing Loss:

(show all 13)
# Title Authors Year
1
Novel SS-31 modified liposomes for improved protective efficacy of minocycline against drug-induced hearing loss. ( 29740652 )
2018
2
Upregulation of HSP60 expression in the postnatal rat cochlea and rats with drug-induced hearing loss. ( 30196524 )
2018
3
Drug-induced hearing loss: Infection raises the odds. ( 26223298 )
2015
4
Drug-induced hearing loss. ( 25629145 )
2014
5
Intravenous administration of human mesenchymal stem cells after noise- or drug-induced hearing loss in rats. ( 22582790 )
2012
6
The role of ultrahigh-frequency audiometry in the early detection of systemic drug-induced hearing loss. ( 21563089 )
2011
7
Prevention of noise- and drug-induced hearing loss with D-methionine. ( 17224251 )
2007
8
Sketches of otohistory. Part 11: Ototoxicity: drug-induced hearing loss. ( 16219991 )
2006
9
Global problem of drug-induced hearing loss. ( 10842579 )
1999
10
Molecular mechanisms of drug-induced hearing loss. ( 3015857 )
1986
11
Protecting the elderly against drug-induced hearing loss. ( 7227822 )
1981
12
Familial occurrence of drug-induced hearing loss. ( 4810278 )
1974
13
Noise-and drug-induced hearing loss in monkeys. ( 4196999 )
1973

Variations for Drug-Induced Hearing Loss

Expression for Drug-Induced Hearing Loss

Search GEO for disease gene expression data for Drug-Induced Hearing Loss.

Pathways for Drug-Induced Hearing Loss

GO Terms for Drug-Induced Hearing Loss

Cellular components related to Drug-Induced Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 9.02 BDNF GJB2 HMOX1 NOX4 NTRK2
2 connexin complex GO:0005922 8.96 GJB2 GJB3

Biological processes related to Drug-Induced Hearing Loss according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.91 GDNF HSPD1 JUN MAPK8 NTRK2
2 regulation of signaling receptor activity GO:0010469 9.89 ARTN BDNF GDNF NRTN PSPN
3 nervous system development GO:0007399 9.8 BDNF GDNF GFRA1 NRTN NTRK2 PSPN
4 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.71 BDNF NRTN NTRK2
5 MAPK cascade GO:0000165 9.65 ARTN GDNF GFRA1 NRTN PSPN
6 response to hydrogen peroxide GO:0042542 9.63 HMOX1 HSPD1 JUN
7 positive regulation of apoptotic process GO:0043065 9.63 HMOX1 HRK HSPD1 JUN MAPK8 NOX4
8 cellular response to cadmium ion GO:0071276 9.58 HMOX1 JUN MAPK8
9 neurotrophin TRK receptor signaling pathway GO:0048011 9.56 BDNF NTRK2
10 protein maturation GO:0051604 9.55 HSPD1 SERPINH1
11 peripheral nervous system development GO:0007422 9.54 ARTN BDNF GDNF
12 nerve development GO:0021675 9.52 BDNF NRTN
13 positive regulation of non-membrane spanning protein tyrosine kinase activity GO:1903997 9.48 BDNF NTRK2
14 brain-derived neurotrophic factor receptor signaling pathway GO:0031547 9.43 BDNF NTRK2
15 axon guidance GO:0007411 9.43 ARTN BDNF GDNF GFRA1 NRTN PSPN
16 negative regulation of neuron apoptotic process GO:0043524 9.1 BDNF GDNF HMOX1 HSPD1 JUN NTRK2

Molecular functions related to Drug-Induced Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.55 ARTN GDNF GFRA1 NRTN PSPN
2 growth factor activity GO:0008083 9.35 ARTN BDNF GDNF NRTN PSPN
3 gap junction channel activity GO:0005243 9.26 GJB2 GJB3
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.02 ARTN GDNF GFRA1 NRTN PSPN

Sources for Drug-Induced Hearing Loss

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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