MCID: DRG025
MIFTS: 22

Drug-Induced Hearing Loss

Categories: Ear diseases

Aliases & Classifications for Drug-Induced Hearing Loss

MalaCards integrated aliases for Drug-Induced Hearing Loss:

Name: Drug-Induced Hearing Loss 12 15
Drug Induced Hearing Loss 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0070310

Summaries for Drug-Induced Hearing Loss

Disease Ontology : 12 A nonsyndromic deafness that is characterized by cochlear or vestibular dysfunction resulting in loss of hearing caused by drug ototoxicity.

MalaCards based summary : Drug-Induced Hearing Loss, also known as drug induced hearing loss, is related to branchiootic syndrome 1 and deafness, aminoglycoside-induced. An important gene associated with Drug-Induced Hearing Loss is MT-RNR1 (Mitochondrially Encoded 12S RRNA). Affiliated tissues include brain, and related phenotype is hearing/vestibular/ear.

Related Diseases for Drug-Induced Hearing Loss

Diseases related to Drug-Induced Hearing Loss via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 branchiootic syndrome 1 30.2 SLC26A4 MYO7A GJB2
2 deafness, aminoglycoside-induced 29.8 UCN TRMU TFB1M MT-TS1 MT-TK MT-RNR2
3 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.6
4 congenital cytomegalovirus 10.5 MT-RNR1 GJB2
5 auditory neuropathy spectrum disorder 10.4 MYO7A MT-RNR1
6 deafness, autosomal dominant 51 10.4 MT-TS1 MT-RNR1
7 deafness, autosomal recessive 3 10.4 MYO7A GJB2
8 viral labyrinthitis 10.3 GJB2 ATOH1
9 optic atrophy 6 10.3 MT-ND6 MT-ND4
10 nonsyndromic hearing loss and deafness, mitochondrial 10.3 TRMU MT-TS1 MT-RNR1
11 deafness, autosomal dominant 1 10.3 MYO7A GJB2
12 toxic optic neuropathy 10.3 MT-ND6 MT-ND4
13 myopathy, lactic acidosis, and sideroblastic anemia 10.3 TRMU GTPBP3
14 optic atrophy 4 10.3 MT-ND6 MT-ND4
15 usher syndrome, type ic 10.3 MYO7A GJB2
16 deafness, autosomal recessive 77 10.2 SLC26A4 GJB2
17 deafness, autosomal dominant 56 10.2 SLC26A4 GJB2
18 thelaziasis 10.2 UCN MT-ND6
19 deafness, autosomal dominant 41 10.2 SLC26A4 GJB2
20 optic atrophy 5 10.2 MT-ND6 MT-ND4
21 deafness, autosomal dominant 11 10.2 MYO7A GJB2
22 deafness, autosomal recessive 83 10.2 SLC26A4 MYO7A
23 deafness, autosomal recessive 16 10.2 SLC26A4 GJB2
24 deafness, autosomal dominant 15 10.2 MYO7A ATOH1
25 leber optic atrophy and dystonia 10.2 MT-ND6 MT-ND4
26 deafness, autosomal dominant 36 10.2 SLC26A4 GJB2
27 cardiomyopathy, infantile hypertrophic 10.1 TRMU GTPBP3
28 sideroblastic anemia with b-cell immunodeficiency, periodic fevers, and developmental delay 10.1 TRMU GTPBP3
29 deafness, autosomal recessive 2 10.1 SLC26A4 MYO7A GJB2
30 otosclerosis 10.1 SLC26A4 MT-RNR1 GJB2
31 autosomal recessive nonsyndromic deafness 10.1 SLC26A4 MYO7A GJB2
32 autosomal recessive nonsyndromic deafness 3 10.1 SLC26A4 MYO7A GJB2
33 deafness, autosomal recessive 26 10.1 TFB1M MT-RNR1 GTPBP3 GJB2
34 deafness, autosomal dominant 6 10.1 SLC26A4 MYO7A GJB2
35 deafness, autosomal recessive 7 10.1 SLC26A4 MYO7A GJB2
36 deafness, autosomal recessive 9 10.1 SLC26A4 MYO7A GJB2
37 usher syndrome, type iia 10.1 SLC26A4 MYO7A GJB2
38 peripheral vertigo 10.1 SLC26A4 MYO7A GJB2
39 usher syndrome, type id 10.1 SLC26A4 MYO7A GJB2
40 deafness, autosomal recessive 12 10.1 SLC26A4 MYO7A GJB2
41 mitochondrial dna depletion syndrome 1 10.1 TFB1M MT-TK
42 usher syndrome type 2 10.1 SLC26A4 MYO7A GJB2
43 ear malformation 10.0 SLC26A4 GJB2 ATOH1
44 serous labyrinthitis 10.0 SLC26A4 GJB2 ATOH1
45 hypotrichosis-deafness syndrome 10.0 GJB3 GJB2
46 nonsyndromic hearing loss and deafness, dfnb1 10.0 GJB3 GJB2
47 pseudoainhum 10.0 GJB3 GJB2
48 hereditary lymphedema ic 10.0 GJB3 GJB2
49 palmoplantar keratoderma and congenital alopecia 1 10.0 GJB3 GJB2
50 erythrokeratoderma 10.0 GJB3 GJB2

Graphical network of the top 20 diseases related to Drug-Induced Hearing Loss:



Diseases related to Drug-Induced Hearing Loss

Symptoms & Phenotypes for Drug-Induced Hearing Loss

MGI Mouse Phenotypes related to Drug-Induced Hearing Loss:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.17 ATOH1 GJB2 GJB3 MYO7A NOX3 SLC26A4

Drugs & Therapeutics for Drug-Induced Hearing Loss

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Prospective Cross-sectional Study Analysing the Utility of Novel Tablet-based Audiometry and an Interactive Web-based Hearing App as Screening Tools for Drug-induced Ototoxicity in Adult Cystic Fibrosis Completed NCT04400955

Search NIH Clinical Center for Drug-Induced Hearing Loss

Genetic Tests for Drug-Induced Hearing Loss

Anatomical Context for Drug-Induced Hearing Loss

MalaCards organs/tissues related to Drug-Induced Hearing Loss:

40
Brain

Publications for Drug-Induced Hearing Loss

Articles related to Drug-Induced Hearing Loss:

(show top 50) (show all 57)
# Title Authors PMID Year
1
Drug-induced hearing loss: a case/non-case study in the French pharmacovigilance database. 61
31912913 2020
2
An Ototoxicity Grading System Within a Mobile App (OtoCalc) for a Resource-Limited Setting to Guide Grading and Management of Drug-Induced Hearing Loss in Patients With Drug-Resistant Tuberculosis: Prospective, Cross-Sectional Case Series. 61
31934875 2020
3
Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies. 61
30559254 2019
4
Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss. 61
31328162 2019
5
Pharmacological intervention in the field of ototoxicity. 61
30993373 2019
6
Otoprotectants: From Research to Clinical Application. 61
31036993 2019
7
Mitochondria-Targeted Antioxidants for Treatment of Hearing Loss: A Systematic Review. 61
31022870 2019
8
Outer hair cells isolation from postnatal Sprague-Dawley rats. 61
30775696 2019
9
Association of Glutathione s-transferase M1 and T1 gene polymorphisms with the susceptibility to acquired sensorineural hearing loss: a systematic review and meta-analysis. 61
30696891 2019
10
Analysis of drug-induced hearing loss by using a spontaneous reporting system database. 61
31593579 2019
11
[Drug-induced hearing loss as a manifestation of drug-induced ototoxicity]. 61
31579063 2019
12
Protection of Hair Cells from Ototoxic Drug-Induced Hearing Loss. 61
30915699 2019
13
Avenanthramide-C prevents noise- and drug-induced hearing loss while protecting auditory hair cells from oxidative stress. 61
31312524 2019
14
Upregulation of HSP60 expression in the postnatal rat cochlea and rats with drug-induced hearing loss. 61
30196524 2018
15
Decreased disulphide/thiol ratio in patients with autosomal recessive non-syndromic hearing loss. 61
30055731 2018
16
Monitoring neonates for ototoxicity. 61
28949262 2018
17
Hearing vulnerability after noise exposure in a mouse model of reactive oxygen species overproduction. 61
29675997 2018
18
Novel SS-31 modified liposomes for improved protective efficacy of minocycline against drug-induced hearing loss. 61
29740652 2018
19
Ototoxicity: A Challenge in Diagnosis and Treatment. 61
29471610 2018
20
Tinnitus and hyperacusis: Contributions of paraflocculus, reticular formation and stress. 61
28286099 2017
21
[Modification factors associated with maternally inherited non-syndromic hearing loss]. 61
28635225 2017
22
Non-autonomous Cellular Responses to Ototoxic Drug-Induced Stress and Death. 61
28878625 2017
23
Potential Mechanisms Underlying Inflammation-Enhanced Aminoglycoside-Induced Cochleotoxicity. 61
29209174 2017
24
Is Hearing Impairment Associated with Rheumatoid Arthritis? A Review. 61
27053970 2016
25
Drug-induced hearing loss: Infection raises the odds. 61
26223298 2015
26
[Study of newborn hearing and genetic screening in Jinan]. 61
26178053 2015
27
A low-dose regimen of cisplatin before high-dose cisplatin potentiates ototoxicity. 61
25267530 2015
28
Age-related hearing impairment and the triad of acquired hearing loss. 61
26283913 2015
29
Reactive oxygen species, apoptosis, and mitochondrial dysfunction in hearing loss. 61
25874222 2015
30
Drug-induced hearing loss. 61
25629145 2014
31
Analysis of the heteroplasmy level and transmitted features in hearing-loss pedigrees with mitochondrial 12S rRNA A1555G mutation. 61
24533451 2014
32
Sound preconditioning therapy inhibits ototoxic hearing loss in mice. 61
24216513 2013
33
Intravenous administration of human mesenchymal stem cells after noise- or drug-induced hearing loss in rats. 61
22582790 2012
34
Activation of apoptotic pathways in the absence of cell death in an inner-ear immortomouse cell line. 61
22240458 2012
35
Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32. 61
21866174 2011
36
Transient ischemia/hypoxia enhances gentamicin ototoxicity via caspase-dependent cell death pathway. 61
21519324 2011
37
The role of ultrahigh-frequency audiometry in the early detection of systemic drug-induced hearing loss. 61
21563089 2011
38
Ototoxic drugs: difference in sensitivity between mice and guinea pigs. 61
20015469 2010
39
Ototoxicity. 61
17653135 2007
40
Auditory research involving antioxidants. 61
17823554 2007
41
Prevention of noise- and drug-induced hearing loss with D-methionine. 61
17224251 2007
42
[Neurotrophic factors of the GDNF family and their receptors are detectable in spiral ganglion cells of normal hearing as well as of deafened rats]. 61
16612752 2006
43
Understanding drug ototoxicity: molecular insights for prevention and clinical management. 61
16610968 2006
44
Sketches of otohistory. Part 11: Ototoxicity: drug-induced hearing loss. 61
16219991 2006
45
Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss. 61
16239342 2005
46
Moderate noise trauma in juvenile cats results in profound cortical topographic map changes in adulthood. 61
10748332 2000
47
The role of antioxidants in protection from impulse noise. 61
10842607 1999
48
Global problem of drug-induced hearing loss. 61
10842579 1999
49
First evidence of otoprotection against carboplatin-induced hearing loss with a two-compartment system in patients with central nervous system malignancy using sodium thiosulfate. 61
9655844 1998
50
[Reduced nutritional status enhances ototoxicity]. 61
8579670 1995

Variations for Drug-Induced Hearing Loss

Expression for Drug-Induced Hearing Loss

Search GEO for disease gene expression data for Drug-Induced Hearing Loss.

Pathways for Drug-Induced Hearing Loss

GO Terms for Drug-Induced Hearing Loss

Cellular components related to Drug-Induced Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 8.96 GJB3 GJB2
2 connexin complex GO:0005922 8.62 GJB3 GJB2

Biological processes related to Drug-Induced Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inner ear auditory receptor cell differentiation GO:0042491 9.16 MYO7A ATOH1
2 inner ear development GO:0048839 9.13 MYO7A GJB2 ATOH1
3 sensory perception of sound GO:0007605 8.92 UCN SLC26A4 MYO7A GJB2

Molecular functions related to Drug-Induced Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction channel activity GO:0005243 8.62 GJB3 GJB2

Sources for Drug-Induced Hearing Loss

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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