MCID: DRG025
MIFTS: 21

Drug-Induced Hearing Loss

Categories: Ear diseases

Aliases & Classifications for Drug-Induced Hearing Loss

MalaCards integrated aliases for Drug-Induced Hearing Loss:

Name: Drug-Induced Hearing Loss 12 15
Drug Induced Hearing Loss 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0070310

Summaries for Drug-Induced Hearing Loss

Disease Ontology : 12 A nonsyndromic deafness that is characterized by cochlear or vestibular dysfunction resulting in loss of hearing caused by drug ototoxicity.

MalaCards based summary : Drug-Induced Hearing Loss, also known as drug induced hearing loss, is related to ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus and hypotrichosis-deafness syndrome. An important gene associated with Drug-Induced Hearing Loss is PSPN (Persephin), and among its related pathways/superpathways are GDNF-Family Ligands and Receptor Interactions and Gap junction trafficking. Affiliated tissues include brain.

Related Diseases for Drug-Induced Hearing Loss

Diseases related to Drug-Induced Hearing Loss via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)
# Related Disease Score Top Affiliating Genes
1 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.5
2 hypotrichosis-deafness syndrome 10.0 GJB3 GJB2
3 deafness, autosomal recessive 93 10.0 GJB3 GJB2
4 kid syndrome 10.0 GJB3 GJB2
5 pseudoainhum 10.0 GJB3 GJB2
6 deafness, autosomal recessive 28 10.0 GJB3 GJB2
7 hodgkin's lymphoma, nodular sclerosis 10.0 GJB3 GJB2
8 deafness, autosomal recessive 1a 9.9 GJB3 GJB2
9 mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma 9.9 GJB3 GJB2
10 knuckle pads 9.9 GJB3 GJB2
11 vestibular disease 9.9 GJB3 GJB2
12 deafness, aminoglycoside-induced 9.9
13 branchiootic syndrome 1 9.9
14 hearing loss, noise-induced 9.9
15 bacterial infectious disease 9.9
16 erythrokeratodermia variabilis et progressiva 1 9.9 GJB3 GJB2
17 deafness, autosomal recessive 67 9.9 GJB3 GJB2
18 clouston syndrome 9.9 GJB3 GJB2
19 palmoplantar keratosis 9.9 GJB3 GJB2
20 inner ear disease 9.8 GJB3 GJB2
21 auditory system disease 9.8 GJB3 GJB2
22 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 9.8 GJB3 GJB2
23 autosomal recessive non-syndromic sensorineural deafness type dfnb 9.7 GJB3 GJB2
24 megacolon 9.6 NRTN GFRA1
25 nonsyndromic deafness 9.6 GJB3 GJB2
26 thyroid carcinoma, familial medullary 9.5 PSPN GFRA1
27 hirschsprung disease 1 9.4 PSPN NRTN GFRA1
28 sensorineural hearing loss 9.4 GJB3 GJB2

Graphical network of the top 20 diseases related to Drug-Induced Hearing Loss:



Diseases related to Drug-Induced Hearing Loss

Symptoms & Phenotypes for Drug-Induced Hearing Loss

Drugs & Therapeutics for Drug-Induced Hearing Loss

Search Clinical Trials , NIH Clinical Center for Drug-Induced Hearing Loss

Genetic Tests for Drug-Induced Hearing Loss

Anatomical Context for Drug-Induced Hearing Loss

MalaCards organs/tissues related to Drug-Induced Hearing Loss:

41
Brain

Publications for Drug-Induced Hearing Loss

Articles related to Drug-Induced Hearing Loss:

(show top 50) (show all 53)
# Title Authors PMID Year
1
Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss. 38
31328162 2019
2
Pharmacological intervention in the field of ototoxicity. 38
30993373 2019
3
Otoprotectants: From Research to Clinical Application. 38
31036993 2019
4
Mitochondria-Targeted Antioxidants for Treatment of Hearing Loss: A Systematic Review. 38
31022870 2019
5
Outer hair cells isolation from postnatal Sprague-Dawley rats. 38
30775696 2019
6
Association of Glutathione s-transferase M1 and T1 gene polymorphisms with the susceptibility to acquired sensorineural hearing loss: a systematic review and meta-analysis. 38
30696891 2019
7
Protection of Hair Cells from Ototoxic Drug-Induced Hearing Loss. 38
30915699 2019
8
Avenanthramide-C prevents noise- and drug-induced hearing loss while protecting auditory hair cells from oxidative stress. 38
31312524 2019
9
Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies. 38
30559254 2018
10
Upregulation of HSP60 expression in the postnatal rat cochlea and rats with drug-induced hearing loss. 38
30196524 2018
11
Monitoring neonates for ototoxicity. 38
28949262 2018
12
Decreased disulphide/thiol ratio in patients with autosomal recessive non-syndromic hearing loss. 38
30055731 2018
13
Hearing vulnerability after noise exposure in a mouse model of reactive oxygen species overproduction. 38
29675997 2018
14
Novel SS-31 modified liposomes for improved protective efficacy of minocycline against drug-induced hearing loss. 38
29740652 2018
15
Ototoxicity: A Challenge in Diagnosis and Treatment. 38
29471610 2018
16
Tinnitus and hyperacusis: Contributions of paraflocculus, reticular formation and stress. 38
28286099 2017
17
[Modification factors associated with maternally inherited non-syndromic hearing loss]. 38
28635225 2017
18
Potential Mechanisms Underlying Inflammation-Enhanced Aminoglycoside-Induced Cochleotoxicity. 38
29209174 2017
19
Non-autonomous Cellular Responses to Ototoxic Drug-Induced Stress and Death. 38
28878625 2017
20
Is Hearing Impairment Associated with Rheumatoid Arthritis? A Review. 38
27053970 2016
21
Drug-induced hearing loss: Infection raises the odds. 38
26223298 2015
22
[Study of newborn hearing and genetic screening in Jinan]. 38
26178053 2015
23
A low-dose regimen of cisplatin before high-dose cisplatin potentiates ototoxicity. 38
25267530 2015
24
Age-related hearing impairment and the triad of acquired hearing loss. 38
26283913 2015
25
Reactive oxygen species, apoptosis, and mitochondrial dysfunction in hearing loss. 38
25874222 2015
26
Drug-induced hearing loss. 38
25629145 2014
27
Analysis of the heteroplasmy level and transmitted features in hearing-loss pedigrees with mitochondrial 12S rRNA A1555G mutation. 38
24533451 2014
28
Sound preconditioning therapy inhibits ototoxic hearing loss in mice. 38
24216513 2013
29
Intravenous administration of human mesenchymal stem cells after noise- or drug-induced hearing loss in rats. 38
22582790 2012
30
Activation of apoptotic pathways in the absence of cell death in an inner-ear immortomouse cell line. 38
22240458 2012
31
Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32. 38
21866174 2011
32
Transient ischemia/hypoxia enhances gentamicin ototoxicity via caspase-dependent cell death pathway. 38
21519324 2011
33
The role of ultrahigh-frequency audiometry in the early detection of systemic drug-induced hearing loss. 38
21563089 2011
34
Ototoxic drugs: difference in sensitivity between mice and guinea pigs. 38
20015469 2010
35
Auditory research involving antioxidants. 38
17823554 2007
36
Ototoxicity. 38
17653135 2007
37
Prevention of noise- and drug-induced hearing loss with D-methionine. 38
17224251 2007
38
[Neurotrophic factors of the GDNF family and their receptors are detectable in spiral ganglion cells of normal hearing as well as of deafened rats]. 38
16612752 2006
39
Understanding drug ototoxicity: molecular insights for prevention and clinical management. 38
16610968 2006
40
Sketches of otohistory. Part 11: Ototoxicity: drug-induced hearing loss. 38
16219991 2006
41
Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss. 38
16239342 2005
42
Moderate noise trauma in juvenile cats results in profound cortical topographic map changes in adulthood. 38
10748332 2000
43
Global problem of drug-induced hearing loss. 38
10842579 1999
44
The role of antioxidants in protection from impulse noise. 38
10842607 1999
45
First evidence of otoprotection against carboplatin-induced hearing loss with a two-compartment system in patients with central nervous system malignancy using sodium thiosulfate. 38
9655844 1998
46
[Reduced nutritional status enhances ototoxicity]. 38
8579670 1995
47
A new approach to serial monitoring of ultra-high frequency hearing. 38
1865730 1991
48
Auditory nerve and brain stem evoked response thresholds in infants treated with gentamicin as neonates. 38
2705702 1989
49
Molecular mechanisms of drug-induced hearing loss. 38
3015857 1986
50
Age-dependent changes in susceptibility to ototoxic hearing loss. 38
6524339 1984

Variations for Drug-Induced Hearing Loss

Expression for Drug-Induced Hearing Loss

Search GEO for disease gene expression data for Drug-Induced Hearing Loss.

Pathways for Drug-Induced Hearing Loss

Pathways related to Drug-Induced Hearing Loss according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.35 PSPN NRTN GFRA1
2
Show member pathways
11.15 GJB3 GJB2
3 10.37 PSPN NRTN GFRA1

GO Terms for Drug-Induced Hearing Loss

Cellular components related to Drug-Induced Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 8.96 GJB3 GJB2
2 connexin complex GO:0005922 8.62 GJB3 GJB2

Biological processes related to Drug-Induced Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.43 PSPN NRTN GFRA1
2 cell communication GO:0007154 9.16 GJB3 GJB2
3 MAPK cascade GO:0000165 9.13 PSPN NRTN GFRA1
4 axon guidance GO:0007411 8.8 PSPN NRTN GFRA1

Molecular functions related to Drug-Induced Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.16 PSPN NRTN
2 signaling receptor binding GO:0005102 9.13 PSPN NRTN GFRA1
3 gap junction channel activity GO:0005243 8.62 GJB3 GJB2

Sources for Drug-Induced Hearing Loss

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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