MCID: DRG025
MIFTS: 22

Drug-Induced Hearing Loss

Categories: Ear diseases

Aliases & Classifications for Drug-Induced Hearing Loss

MalaCards integrated aliases for Drug-Induced Hearing Loss:

Name: Drug-Induced Hearing Loss 12 15
Drug Induced Hearing Loss 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0070310

Summaries for Drug-Induced Hearing Loss

Disease Ontology : 12 A nonsyndromic deafness that is characterized by cochlear or vestibular dysfunction resulting in loss of hearing caused by drug ototoxicity.

MalaCards based summary : Drug-Induced Hearing Loss, also known as drug induced hearing loss, is related to hearing loss, noise-induced and branchiootic syndrome 1. An important gene associated with Drug-Induced Hearing Loss is CDH23 (Cadherin Related 23), and among its related pathways/superpathways is Platinum Pathway, Pharmacokinetics/Pharmacodynamics. Affiliated tissues include brain, and related phenotype is hearing/vestibular/ear.

Related Diseases for Drug-Induced Hearing Loss

Diseases related to Drug-Induced Hearing Loss via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 hearing loss, noise-induced 30.2 GSTM1 CDH23
2 branchiootic syndrome 1 29.8 MYO7A CDH23
3 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.6
4 retinitis pigmentosa-deafness syndrome 10.3 MYO7A CDH23
5 usher syndrome, type ih 10.3 MYO7A CDH23
6 deafness, autosomal recessive 83 10.3 MYO7A CDH23
7 autosomal recessive nonsyndromic deafness 3 10.3 MYO7A CDH23
8 usher syndrome, type ij 10.3 MYO7A CDH23
9 usher syndrome, type iid 10.2 MYO7A CDH23
10 deafness, autosomal dominant 36 10.2 TMC2 CDH23
11 deafness, autosomal recessive 2 10.2 MYO7A CDH23
12 deafness, autosomal recessive 48 10.2 TMC2 MYO7A
13 deafness, autosomal recessive 23 10.2 MYO7A CDH23
14 dfnb1 10.2 MYO7A GJB3
15 usher syndrome, type if 10.1 MYO7A CDH23
16 deafness, autosomal recessive 7 10.1 TMC2 CDH23
17 usher syndrome, type iic 10.1 MYO7A CDH23
18 usher syndrome, type i 10.1 TMC2 MYO7A CDH23
19 usher syndrome, type ic 10.1 TMC2 MYO7A CDH23
20 autosomal recessive nonsyndromic deafness 10.1 TMC2 MYO7A CDH23
21 usher syndrome, type id 10.0 MYO7A CDH23
22 hodgkin's lymphoma, nodular sclerosis 10.0 MYO7A GJB3 CDH23
23 vestibular disease 10.0 MYO7A GJB3 CDH23
24 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 10.0 MYO7A GJB3 CDH23
25 autosomal recessive non-syndromic sensorineural deafness type dfnb 10.0 MYO7A GJB3 CDH23
26 inner ear disease 10.0 MYO7A GJB3 CDH23
27 deafness, autosomal recessive 12 10.0 MYO7A CDH23
28 deafness, autosomal dominant 1 9.9 POU4F3 MYO7A
29 diaphragmatic hernia, congenital 9.9
30 deafness, aminoglycoside-induced 9.9
31 bacterial infectious disease 9.9
32 impotence 9.9
33 deafness, autosomal dominant 20 9.9 POU4F3 CDH23
34 deafness, autosomal dominant 9 9.8 POU4F3 MYO7A
35 deafness, autosomal dominant 6 9.8 POU4F3 MYO7A
36 deafness, autosomal dominant 15 9.8 POU4F3 MYO7A
37 deafness, autosomal dominant 11 9.7 POU4F3 MYO7A CDH23
38 autosomal dominant non-syndromic sensorineural deafness type dfna 9.6 POU4F3 MYO7A GJB3
39 sensorineural hearing loss 9.3 POU4F3 MYO7A GJB3 CDH23
40 auditory system disease 9.1 TMC2 POU4F3 MYO7A GJB3 CDH23
41 autosomal dominant nonsyndromic deafness 9.1 TMC2 POU4F3 MYO7A GJB3 CDH23
42 nonsyndromic deafness 8.7 TMC2 POU4F3 MYO7A GTPBP3 GJB3 CDH23

Graphical network of the top 20 diseases related to Drug-Induced Hearing Loss:



Diseases related to Drug-Induced Hearing Loss

Symptoms & Phenotypes for Drug-Induced Hearing Loss

MGI Mouse Phenotypes related to Drug-Induced Hearing Loss:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 9.1 CDH23 GJB3 MYO7A NOX3 POU4F3 TMC2

Drugs & Therapeutics for Drug-Induced Hearing Loss

Search Clinical Trials , NIH Clinical Center for Drug-Induced Hearing Loss

Genetic Tests for Drug-Induced Hearing Loss

Anatomical Context for Drug-Induced Hearing Loss

MalaCards organs/tissues related to Drug-Induced Hearing Loss:

40
Brain

Publications for Drug-Induced Hearing Loss

Articles related to Drug-Induced Hearing Loss:

(show top 50) (show all 57)
# Title Authors PMID Year
1
Drug-induced hearing loss: a case/non-case study in the French pharmacovigilance database. 61
31912913 2020
2
An Ototoxicity Grading System Within a Mobile App (OtoCalc) for a Resource-Limited Setting to Guide Grading and Management of Drug-Induced Hearing Loss in Patients With Drug-Resistant Tuberculosis: Prospective, Cross-Sectional Case Series. 61
31934875 2020
3
Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies. 61
30559254 2019
4
Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss. 61
31328162 2019
5
Pharmacological intervention in the field of ototoxicity. 61
30993373 2019
6
Otoprotectants: From Research to Clinical Application. 61
31036993 2019
7
Mitochondria-Targeted Antioxidants for Treatment of Hearing Loss: A Systematic Review. 61
31022870 2019
8
Outer hair cells isolation from postnatal Sprague-Dawley rats. 61
30775696 2019
9
Association of Glutathione s-transferase M1 and T1 gene polymorphisms with the susceptibility to acquired sensorineural hearing loss: a systematic review and meta-analysis. 61
30696891 2019
10
Analysis of drug-induced hearing loss by using a spontaneous reporting system database. 61
31593579 2019
11
[Drug-induced hearing loss as a manifestation of drug-induced ototoxicity]. 61
31579063 2019
12
Protection of Hair Cells from Ototoxic Drug-Induced Hearing Loss. 61
30915699 2019
13
Avenanthramide-C prevents noise- and drug-induced hearing loss while protecting auditory hair cells from oxidative stress. 61
31312524 2019
14
Upregulation of HSP60 expression in the postnatal rat cochlea and rats with drug-induced hearing loss. 61
30196524 2018
15
Decreased disulphide/thiol ratio in patients with autosomal recessive non-syndromic hearing loss. 61
30055731 2018
16
Monitoring neonates for ototoxicity. 61
28949262 2018
17
Hearing vulnerability after noise exposure in a mouse model of reactive oxygen species overproduction. 61
29675997 2018
18
Novel SS-31 modified liposomes for improved protective efficacy of minocycline against drug-induced hearing loss. 61
29740652 2018
19
Ototoxicity: A Challenge in Diagnosis and Treatment. 61
29471610 2018
20
Tinnitus and hyperacusis: Contributions of paraflocculus, reticular formation and stress. 61
28286099 2017
21
[Modification factors associated with maternally inherited non-syndromic hearing loss]. 61
28635225 2017
22
Non-autonomous Cellular Responses to Ototoxic Drug-Induced Stress and Death. 61
28878625 2017
23
Potential Mechanisms Underlying Inflammation-Enhanced Aminoglycoside-Induced Cochleotoxicity. 61
29209174 2017
24
Is Hearing Impairment Associated with Rheumatoid Arthritis? A Review. 61
27053970 2016
25
Drug-induced hearing loss: Infection raises the odds. 61
26223298 2015
26
[Study of newborn hearing and genetic screening in Jinan]. 61
26178053 2015
27
A low-dose regimen of cisplatin before high-dose cisplatin potentiates ototoxicity. 61
25267530 2015
28
Age-related hearing impairment and the triad of acquired hearing loss. 61
26283913 2015
29
Reactive oxygen species, apoptosis, and mitochondrial dysfunction in hearing loss. 61
25874222 2015
30
Drug-induced hearing loss. 61
25629145 2014
31
Analysis of the heteroplasmy level and transmitted features in hearing-loss pedigrees with mitochondrial 12S rRNA A1555G mutation. 61
24533451 2014
32
Sound preconditioning therapy inhibits ototoxic hearing loss in mice. 61
24216513 2013
33
Intravenous administration of human mesenchymal stem cells after noise- or drug-induced hearing loss in rats. 61
22582790 2012
34
Activation of apoptotic pathways in the absence of cell death in an inner-ear immortomouse cell line. 61
22240458 2012
35
Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32. 61
21866174 2011
36
Transient ischemia/hypoxia enhances gentamicin ototoxicity via caspase-dependent cell death pathway. 61
21519324 2011
37
The role of ultrahigh-frequency audiometry in the early detection of systemic drug-induced hearing loss. 61
21563089 2011
38
Ototoxic drugs: difference in sensitivity between mice and guinea pigs. 61
20015469 2010
39
Ototoxicity. 61
17653135 2007
40
Auditory research involving antioxidants. 61
17823554 2007
41
Prevention of noise- and drug-induced hearing loss with D-methionine. 61
17224251 2007
42
[Neurotrophic factors of the GDNF family and their receptors are detectable in spiral ganglion cells of normal hearing as well as of deafened rats]. 61
16612752 2006
43
Understanding drug ototoxicity: molecular insights for prevention and clinical management. 61
16610968 2006
44
Sketches of otohistory. Part 11: Ototoxicity: drug-induced hearing loss. 61
16219991 2006
45
Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss. 61
16239342 2005
46
Moderate noise trauma in juvenile cats results in profound cortical topographic map changes in adulthood. 61
10748332 2000
47
The role of antioxidants in protection from impulse noise. 61
10842607 1999
48
Global problem of drug-induced hearing loss. 61
10842579 1999
49
First evidence of otoprotection against carboplatin-induced hearing loss with a two-compartment system in patients with central nervous system malignancy using sodium thiosulfate. 61
9655844 1998
50
[Reduced nutritional status enhances ototoxicity]. 61
8579670 1995

Variations for Drug-Induced Hearing Loss

Expression for Drug-Induced Hearing Loss

Search GEO for disease gene expression data for Drug-Induced Hearing Loss.

Pathways for Drug-Induced Hearing Loss

Pathways related to Drug-Induced Hearing Loss according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.09 SLC31A1 GSTM1

GO Terms for Drug-Induced Hearing Loss

Cellular components related to Drug-Induced Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.02 SLC31A1 MYO7A GCM2 ENDOG CDH23
2 stereocilium GO:0032420 8.96 MYO7A CDH23

Biological processes related to Drug-Induced Hearing Loss according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.58 POU4F3 MYO7A CDH23
2 sensory perception of sound GO:0007605 9.5 POU4F3 MYO7A CDH23
3 inner ear development GO:0048839 9.43 POU4F3 MYO7A
4 inner ear receptor cell stereocilium organization GO:0060122 9.37 MYO7A CDH23
5 sensory perception of light stimulus GO:0050953 9.26 MYO7A CDH23
6 inner ear receptor cell differentiation GO:0060113 9.16 POU4F3 MYO7A
7 equilibrioception GO:0050957 8.96 MYO7A CDH23
8 inner ear auditory receptor cell differentiation GO:0042491 8.62 POU4F3 MYO7A

Sources for Drug-Induced Hearing Loss

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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