DIL
MCID: DRG013
MIFTS: 47

Drug-Induced Lupus Erythematosus (DIL)

Categories: Bone diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Drug-Induced Lupus Erythematosus

MalaCards integrated aliases for Drug-Induced Lupus Erythematosus:

Name: Drug-Induced Lupus Erythematosus 12 59 15 73
Dile 12 59
Dil 12

Characteristics:

Orphanet epidemiological data:

59
drug-induced lupus erythematosus
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:0040093
ICD10 33 M32.0
Orphanet 59 ORPHA231111
UMLS via Orphanet 74 C0263591
ICD10 via Orphanet 34 M32.0
UMLS 73 C0263591

Summaries for Drug-Induced Lupus Erythematosus

Disease Ontology : 12 A lupus erythematosus caused by chronic use of certain drugs.

MalaCards based summary : Drug-Induced Lupus Erythematosus, also known as dile, is related to lupus erythematosus and pemphigus foliaceus. An important gene associated with Drug-Induced Lupus Erythematosus is KDR (Kinase Insert Domain Receptor), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Infliximab and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and brain, and related phenotypes are fever and arthralgia

Wikipedia : 76 Drug-induced lupus erythematosus (DIL or DILE) is an autoimmune disorder (similar to systemic lupus... more...

Related Diseases for Drug-Induced Lupus Erythematosus

Diseases related to Drug-Induced Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 lupus erythematosus 10.8
2 pemphigus foliaceus 10.2
3 spleen angiosarcoma 10.2 HBA1 VWF
4 kaposiform hemangioendothelioma 10.2 KDR VWF
5 senile angioma 10.2 HBA1 KDR
6 pediatric angiosarcoma 10.2 HBA1 VEGFA
7 angiokeratoma circumscriptum 10.2 KDR VEGFA
8 hypoglycemic coma 10.2 HBA1 VEGFA
9 infiltrating angiolipoma 10.2 VEGFA VWF
10 radiation proctitis 10.2 KDR VEGFA
11 epithelioid hemangioendothelioma 10.1 KDR VEGFA
12 liver angiosarcoma 10.1 HBA1 VWF
13 leukostasis 10.1 KDR VEGFA
14 vascular hemostatic disease 10.1 F12 HBA1
15 skin hemangioma 10.1 HBA1 KDR VEGFA
16 capillary hemangioma 10.1 HBA1 KDR VEGFA
17 angiomatous meningioma 10.1 HBA1 KDR VEGFA
18 lymphangioma 10.1 HBA1 KDR VEGFA
19 angiosarcoma 10.1 KDR VEGFA VWF
20 lymphangiosarcoma 10.1 HBA1 VEGFA VWF
21 diffuse infiltrative lymphocytosis syndrome 10.1
22 limb ischemia 10.1 KDR VEGFA VWF
23 retinal vascular disease 10.1 HBA1 KDR VEGFA
24 epileptic encephalopathy, childhood-onset 10.1 KDR PROM1 VEGFA
25 supratentorial cancer 10.1 KDR PROM1 VEGFA
26 cerebrum cancer 10.1 KDR PROM1 VEGFA
27 bone squamous cell carcinoma 10.1 ENG KDR
28 cloacogenic carcinoma 10.1 F12 HBA1
29 ovarian hyperstimulation syndrome 10.1 CDH5 KDR VEGFA
30 gastrointestinal system cancer 10.1 KDR PROM1 VEGFA
31 splenomegaly 10.1
32 syndromic x-linked intellectual disability snyder type 10.1 OLR1 SCARB1
33 spastic paraplegia 3, autosomal dominant 10.0 CDH5 HBA1
34 large intestine cancer 10.0 HBA1 KDR PROM1 VEGFA
35 glomeruloid hemangioma 10.0 ENG HBA1 VEGFA
36 angiodysplasia 10.0 ENG VEGFA VWF
37 arteriovenous malformations of the brain 10.0 ENG KDR VEGFA
38 progressive familial heart block, type ia 9.9
39 cardiac conduction defect 9.9
40 fabry disease 9.9
41 tropical calcific pancreatitis 9.9
42 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
43 left bundle branch hemiblock 9.9
44 acute cystitis 9.9
45 neuropathy 9.9
46 hypertrophic cardiomyopathy 9.9
47 cerebral aneurysms 9.9
48 coats disease 9.9 KDR VEGFA
49 telangiectasis 9.9 ENG VEGFA
50 thrombocytopenia 9.9

Graphical network of the top 20 diseases related to Drug-Induced Lupus Erythematosus:



Diseases related to Drug-Induced Lupus Erythematosus

Symptoms & Phenotypes for Drug-Induced Lupus Erythematosus

Human phenotypes related to Drug-Induced Lupus Erythematosus:

59 32 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 59 32 frequent (33%) Frequent (79-30%) HP:0001945
2 arthralgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002829
3 dyspnea 59 32 hallmark (90%) Very frequent (99-80%) HP:0002094
4 elevated serum creatine phosphokinase 59 32 hallmark (90%) Very frequent (99-80%) HP:0003236
5 anemia 59 32 hallmark (90%) Very frequent (99-80%) HP:0001903
6 thrombocytopenia 59 32 hallmark (90%) Very frequent (99-80%) HP:0001873
7 myalgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0003326
8 hematuria 59 32 hallmark (90%) Very frequent (99-80%) HP:0000790
9 pericarditis 59 32 hallmark (90%) Very frequent (99-80%) HP:0001701
10 petechiae 59 32 hallmark (90%) Very frequent (99-80%) HP:0000967
11 elevated c-reactive protein level 59 32 hallmark (90%) Very frequent (99-80%) HP:0011227
12 elevated erythrocyte sedimentation rate 59 32 hallmark (90%) Very frequent (99-80%) HP:0003565
13 antinuclear antibody positivity 59 32 hallmark (90%) Very frequent (99-80%) HP:0003493
14 pericardial effusion 59 32 hallmark (90%) Very frequent (99-80%) HP:0001698
15 increased blood urea nitrogen 59 32 hallmark (90%) Very frequent (99-80%) HP:0003138
16 prolonged qtc interval 59 32 hallmark (90%) Very frequent (99-80%) HP:0005184
17 decreased serum complement c3 59 32 hallmark (90%) Very frequent (99-80%) HP:0005421
18 malar rash 59 32 hallmark (90%) Very frequent (99-80%) HP:0025300
19 lupus anticoagulant 59 32 hallmark (90%) Very frequent (99-80%) HP:0025343
20 decreased serum complement c4 59 32 hallmark (90%) Very frequent (99-80%) HP:0045042
21 autoimmune antibody positivity 59 Very frequent (99-80%)
22 constitutional symptom 59 Occasional (29-5%)
23 serositis 59 Frequent (79-30%)

MGI Mouse Phenotypes related to Drug-Induced Lupus Erythematosus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 ABCA1 CDH5 ENG KDR KLKB1 MCAM
2 homeostasis/metabolism MP:0005376 10 ABCA1 CDH5 ENG F12 KDR KLKB1
3 hematopoietic system MP:0005397 9.92 ABCA1 CDH5 ENG KDR MCAM SCARB1
4 immune system MP:0005387 9.76 ABCA1 CDH5 KDR MCAM OLR1 SCARB1
5 muscle MP:0005369 9.43 ABCA1 ENG KDR OLR1 SCARB1 VEGFA
6 normal MP:0002873 9.17 CDH5 ENG F12 KDR OLR1 PROM1

Drugs & Therapeutics for Drug-Induced Lupus Erythematosus

Drugs for Drug-Induced Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved 170277-31-3
2 Antirheumatic Agents
3 Dermatologic Agents
4 Gastrointestinal Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 a Single-center Registered Clinical Research of Chinese Patients With Moderate to Severe Crohn's Disease Unknown status NCT02088944 Infliximab
2 Autoimmune Paradoxical Reactions in IBD Longitudinal Cohort Completed NCT02503514

Search NIH Clinical Center for Drug-Induced Lupus Erythematosus

Genetic Tests for Drug-Induced Lupus Erythematosus

Anatomical Context for Drug-Induced Lupus Erythematosus

MalaCards organs/tissues related to Drug-Induced Lupus Erythematosus:

41
Skin, Bone, Brain, Liver, Heart, Breast, Spleen

Publications for Drug-Induced Lupus Erythematosus

Articles related to Drug-Induced Lupus Erythematosus:

(show all 49)
# Title Authors Year
1
Response to: 'Drug-induced lupus erythematosus following immunotherapy with anti-programmed death-(ligand) 1' by Michot <i>et al</i>. ( 29934372 )
2018
2
Drug-induced lupus erythematosus secondary to pirfenidone. ( 29266198 )
2018
3
Drug-induced lupus erythematosus: an update on drugs and mechanisms. ( 29870500 )
2018
4
Drug-induced lupus erythematosus following immunotherapy with anti-programmed death-(ligand) 1. ( 29858173 )
2018
5
A case of lupus-like syndrome in a patient receiving adalimumab and a brief review of the literature on drug-induced lupus erythematosus. ( 28191663 )
2017
6
Drug-induced lupus erythematosus mimicking lymphoma on (18)F-FDG-PET/CT. ( 28420045 )
2017
7
Drug-Induced Lupus Erythematosus Associated with Antiretroviral Therapy in a Patient with Human Immunodeficiency Virus: A Case Report. ( 29147636 )
2017
8
A case of drug-induced lupus erythematosus secondary to trimethoprim/sulfamethoxazole presenting with pleural effusions and pericardial tamponade. ( 27357280 )
2016
9
Drug Induced Lupus Erythematosus Due to Capecitabine and Bevacizumab Treatment Presenting with Prolonged Thrombocytopenia. ( 26710505 )
2015
10
Drug-induced lupus erythematosus associated with donepezil: a case report. ( 26420637 )
2015
11
Drug-induced lupus erythematosus. ( 24819757 )
2014
12
Drug-Induced Lupus Erythematosus Presenting With Cardiac Tamponade: A Case Report and Literature Review. ( 24373757 )
2013
13
Drug-induced lupus erythematosus with emphasis on skin manifestations and the role of anti-TNFI+ agents. ( 22937775 )
2012
14
Drug-Induced Lupus Erythematosus. ( 23164669 )
2012
15
Drug-induced lupus erythematosus: incidence, management and prevention. ( 21513360 )
2011
16
Episcleritis Related to Drug-Induced Lupus Erythematosus following Infliximab Therapy: A Case Report. ( 21547267 )
2011
17
Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men. ( 20376687 )
2010
18
Drug reaction with herbal supplement: a possible case of drug induced lupus erythematosus. ( 25606196 )
2010
19
Drug-induced lupus erythematosus. ( 18797892 )
2009
20
Drug-induced lupus erythematosus in a patient treated with adalumimab. ( 17434034 )
2007
21
Drug-induced lupus erythematosus. ( 16373256 )
2005
22
Drug-induced lupus erythematosus. ( 15234017 )
2004
23
The utility of antihistone antibody screening in the diagnosis of drug-induced lupus erythematosus. ( 15096389 )
2004
24
Drug-induced lupus erythematosus secondary to nafcillin: the first reported case. ( 14658003 )
2004
25
Drug-induced lupus erythematosus by amiodarone. ( 11926860 )
2002
26
Chlorpromazine induces apoptosis in activated human lymphoblasts: a mechanism supporting the induction of drug-induced lupus erythematosus? ( 11014349 )
2000
27
Drug-induced lupus erythematosus. ( 9642530 )
1998
28
Antibodies to dsDNA in drug induced lupus erythematosus. ( 8006909 )
1994
29
Reticuloendothelial system Fc receptor function in the drug induced lupus erythematosus syndrome. ( 3772920 )
1986
30
Antihistone antibodies and drug-induced lupus erythematosus. ( 3947411 )
1986
31
The diagnostic value of antihistone antibodies in drug-induced lupus erythematosus. ( 3882094 )
1985
32
Reactive hypoglycemia and insulin autoantibodies in drug-induced lupus erythematosus. ( 6349454 )
1983
33
The heterogeneity of serologic findings and predisposing host factors in drug-induced lupus erythematosus. ( 6974553 )
1981
34
Drug-induced lupus erythematosus aggravated by oral zinc therapy. ( 92157 )
1979
35
Lymphocyte alteration by procainamide: relation to drug-induced lupus erythematosus syndrome. ( 90917 )
1979
36
Drug-induced lupus erythematosus. ( 421513 )
1979
37
Procainamide, acetylprocainamide, and drug-induced lupus erythematosus. ( 91813 )
1979
38
Drug-induced lupus erythematosus with in vivo lupus erythematosus cells in pleural fluid. ( 77754 )
1978
39
Drug induced lupus erythematosus--a case report. ( 687309 )
1978
40
Drug-induced lupus erythematosus. ( 68769 )
1977
41
Medical grand rounds--from the Medical College of Virginia. Drug-induced lupus erythematosus. ( 4545011 )
1974
42
Drug-induced lupus erythematosus syndrome. Immuno-pathological, electronmicroscopical and serological studies. ( 4138086 )
1974
43
Studies on drug-induced lupus erythematosus in mice. 3. Renal lesions and splenomegaly in drug-induced lupus erythematosus. ( 4273216 )
1973
44
Studies on drug-induced lupus erythematosus in mice. II. Drug-induced smooth muscle and skeletal muscle antibodies. ( 4587506 )
1973
45
Biologic false-positive FTA-ABS test in drug-induced lupus erythematosus. ( 4574098 )
1973
46
Drug-induced lupus erythematosus. ( 4803375 )
1973
47
Studies on drug induced lupus erythematosus in mice. I. Drug induced antinuclear antibodies (ANA). ( 4557182 )
1972
48
Drug-induced lupus erythematosus. ( 5473639 )
1970
49
Atresia of the intrahepatic dile ducts. ( 14891320 )
1951

Variations for Drug-Induced Lupus Erythematosus

Expression for Drug-Induced Lupus Erythematosus

Search GEO for disease gene expression data for Drug-Induced Lupus Erythematosus.

Pathways for Drug-Induced Lupus Erythematosus

GO Terms for Drug-Induced Lupus Erythematosus

Cellular components related to Drug-Induced Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 ARL8A F12 HBA1 KLKB1 PROM1 SCARB1
2 extracellular space GO:0005615 9.8 ENG F12 HBA1 KLKB1 MCAM PROM1
3 extracellular region GO:0005576 9.76 F12 HBA1 KDR KLKB1 MCAM OLR1
4 plasma membrane GO:0005886 9.7 ABCA1 ARL8A CDH5 ENG F12 KDR
5 external side of plasma membrane GO:0009897 9.62 ABCA1 CDH5 ENG MCAM
6 microvillus membrane GO:0031528 9.4 PROM1 SCARB1
7 cell surface GO:0009986 9.1 ABCA1 CDH5 ENG PROM1 SCARB1 VEGFA

Biological processes related to Drug-Induced Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.88 CDH5 ENG MCAM OLR1 VWF
2 blood coagulation GO:0007596 9.79 F12 KLKB1 VWF
3 positive regulation of protein phosphorylation GO:0001934 9.78 ENG KDR VEGFA
4 angiogenesis GO:0001525 9.76 ENG KDR MCAM VEGFA
5 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.62 KDR VEGFA
6 sprouting angiogenesis GO:0002040 9.61 ENG VEGFA
7 vasculogenesis GO:0001570 9.61 ENG KDR VEGFA
8 branching involved in blood vessel morphogenesis GO:0001569 9.6 ENG VEGFA
9 cholesterol transport GO:0030301 9.59 ABCA1 SCARB1
10 positive regulation of focal adhesion assembly GO:0051894 9.58 KDR VEGFA
11 cholesterol efflux GO:0033344 9.58 ABCA1 SCARB1
12 hemostasis GO:0007599 9.58 F12 KLKB1 VWF
13 artery morphogenesis GO:0048844 9.57 ENG VEGFA
14 fibrinolysis GO:0042730 9.56 F12 KLKB1
15 cell migration involved in sprouting angiogenesis GO:0002042 9.55 KDR VEGFA
16 reverse cholesterol transport GO:0043691 9.54 ABCA1 SCARB1
17 vascular endothelial growth factor signaling pathway GO:0038084 9.52 KDR VEGFA
18 zymogen activation GO:0031638 9.51 F12 KLKB1
19 positive regulation of endothelial cell migration GO:0010595 9.5 KDR SCARB1 VEGFA
20 positive regulation of positive chemotaxis GO:0050927 9.49 KDR VEGFA
21 positive regulation of angiogenesis GO:0045766 9.46 CDH5 ENG KDR VEGFA
22 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.37 KDR VEGFA
23 positive regulation of fibrinolysis GO:0051919 9.26 F12 KLKB1
24 Factor XII activation GO:0002542 8.96 F12 KLKB1
25 blood coagulation, intrinsic pathway GO:0007597 8.8 F12 KLKB1 VWF

Molecular functions related to Drug-Induced Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.97 ABCA1 ARL8A CDH5 ENG F12 HBA1
2 protein homodimerization activity GO:0042803 9.72 CDH5 ENG SCARB1 VEGFA VWF
3 apolipoprotein binding GO:0034185 9.26 ABCA1 SCARB1
4 high-density lipoprotein particle binding GO:0008035 8.96 ABCA1 SCARB1
5 apolipoprotein A-I binding GO:0034186 8.62 ABCA1 SCARB1

Sources for Drug-Induced Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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