MCID: DRG013
MIFTS: 28

Drug-Induced Lupus Erythematosus

Categories: Bone diseases, Skin diseases, Rare diseases

Aliases & Classifications for Drug-Induced Lupus Erythematosus

MalaCards integrated aliases for Drug-Induced Lupus Erythematosus:

Name: Drug-Induced Lupus Erythematosus 59 73
Dile 59

Characteristics:

Orphanet epidemiological data:

59
drug-induced lupus erythematosus
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



Summaries for Drug-Induced Lupus Erythematosus

MalaCards based summary : Drug-Induced Lupus Erythematosus, also known as dile, is related to lupus erythematosus and splenomegaly. The drugs Infliximab and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and smooth muscle, and related phenotypes are hematuria and petechiae

Wikipedia : 76 Drug-induced lupus erythematosus (DIL or DILE) is an autoimmune disorder (similar to systemic lupus... more...

Related Diseases for Drug-Induced Lupus Erythematosus

Diseases related to Drug-Induced Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 lupus erythematosus 10.7
2 splenomegaly 10.0
3 thrombocytopenia 9.8
4 lymphoma 9.8
5 cardiac tamponade 9.8
6 hypoglycemia 9.8

Graphical network of the top 20 diseases related to Drug-Induced Lupus Erythematosus:



Diseases related to Drug-Induced Lupus Erythematosus

Symptoms & Phenotypes for Drug-Induced Lupus Erythematosus

Human phenotypes related to Drug-Induced Lupus Erythematosus:

59 32 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hematuria 59 32 hallmark (90%) Very frequent (99-80%) HP:0000790
2 petechiae 59 32 hallmark (90%) Very frequent (99-80%) HP:0000967
3 pericardial effusion 59 32 hallmark (90%) Very frequent (99-80%) HP:0001698
4 pericarditis 59 32 hallmark (90%) Very frequent (99-80%) HP:0001701
5 thrombocytopenia 59 32 hallmark (90%) Very frequent (99-80%) HP:0001873
6 anemia 59 32 hallmark (90%) Very frequent (99-80%) HP:0001903
7 dyspnea 59 32 hallmark (90%) Very frequent (99-80%) HP:0002094
8 arthralgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0002829
9 increased blood urea nitrogen 59 32 hallmark (90%) Very frequent (99-80%) HP:0003138
10 elevated serum creatine phosphokinase 59 32 hallmark (90%) Very frequent (99-80%) HP:0003236
11 myalgia 59 32 hallmark (90%) Very frequent (99-80%) HP:0003326
12 antinuclear antibody positivity 59 32 hallmark (90%) Very frequent (99-80%) HP:0003493
13 elevated erythrocyte sedimentation rate 59 32 hallmark (90%) Very frequent (99-80%) HP:0003565
14 prolonged qtc interval 59 32 hallmark (90%) Very frequent (99-80%) HP:0005184
15 decreased serum complement c3 59 32 hallmark (90%) Very frequent (99-80%) HP:0005421
16 elevated c-reactive protein level 59 32 hallmark (90%) Very frequent (99-80%) HP:0011227
17 malar rash 59 32 hallmark (90%) Very frequent (99-80%) HP:0025300
18 lupus anticoagulant 59 32 hallmark (90%) Very frequent (99-80%) HP:0025343
19 decreased serum complement c4 59 32 hallmark (90%) Very frequent (99-80%) HP:0045042
20 fever 59 32 frequent (33%) Frequent (79-30%) HP:0001945
21 autoimmune antibody positivity 59 Very frequent (99-80%)
22 serositis 59 Frequent (79-30%)
23 constitutional symptom 59 Occasional (29-5%)

Drugs & Therapeutics for Drug-Induced Lupus Erythematosus

Drugs for Drug-Induced Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved 170277-31-3
2 Gastrointestinal Agents
3 Dermatologic Agents
4 Antirheumatic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 a Single-center Registered Clinical Research of Chinese Patients With Moderate to Severe Crohn's Disease Unknown status NCT02088944 Infliximab
2 Autoimmune Paradoxical Reactions in IBD Longitudinal Cohort Completed NCT02503514

Search NIH Clinical Center for Drug-Induced Lupus Erythematosus

Genetic Tests for Drug-Induced Lupus Erythematosus

Anatomical Context for Drug-Induced Lupus Erythematosus

MalaCards organs/tissues related to Drug-Induced Lupus Erythematosus:

41
Skin, Bone, Smooth Muscle, Testes, Skeletal Muscle

Publications for Drug-Induced Lupus Erythematosus

Articles related to Drug-Induced Lupus Erythematosus:

(show all 49)
# Title Authors Year
1
Response to: 'Drug-induced lupus erythematosus following immunotherapy with anti-programmed death-(ligand) 1' by Michot <i>et al</i>. ( 29934372 )
2018
2
Drug-induced lupus erythematosus secondary to pirfenidone. ( 29266198 )
2018
3
Drug-induced lupus erythematosus: an update on drugs and mechanisms. ( 29870500 )
2018
4
Drug-induced lupus erythematosus following immunotherapy with anti-programmed death-(ligand) 1. ( 29858173 )
2018
5
A case of lupus-like syndrome in a patient receiving adalimumab and a brief review of the literature on drug-induced lupus erythematosus. ( 28191663 )
2017
6
Drug-induced lupus erythematosus mimicking lymphoma on (18)F-FDG-PET/CT. ( 28420045 )
2017
7
Drug-Induced Lupus Erythematosus Associated with Antiretroviral Therapy in a Patient with Human Immunodeficiency Virus: A Case Report. ( 29147636 )
2017
8
A case of drug-induced lupus erythematosus secondary to trimethoprim/sulfamethoxazole presenting with pleural effusions and pericardial tamponade. ( 27357280 )
2016
9
Drug Induced Lupus Erythematosus Due to Capecitabine and Bevacizumab Treatment Presenting with Prolonged Thrombocytopenia. ( 26710505 )
2015
10
Drug-induced lupus erythematosus associated with donepezil: a case report. ( 26420637 )
2015
11
Drug-induced lupus erythematosus. ( 24819757 )
2014
12
Drug-Induced Lupus Erythematosus Presenting With Cardiac Tamponade: A Case Report and Literature Review. ( 24373757 )
2013
13
Drug-Induced Lupus Erythematosus. ( 24388458 )
2013
14
Drug-induced lupus erythematosus with emphasis on skin manifestations and the role of anti-TNFI+ agents. ( 22937775 )
2012
15
Drug-Induced Lupus Erythematosus. ( 23164669 )
2012
16
Drug-induced lupus erythematosus: incidence, management and prevention. ( 21513360 )
2011
17
Episcleritis Related to Drug-Induced Lupus Erythematosus following Infliximab Therapy: A Case Report. ( 21547267 )
2011
18
Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men. ( 20376687 )
2010
19
Drug reaction with herbal supplement: a possible case of drug induced lupus erythematosus. ( 25606196 )
2010
20
Drug-induced lupus erythematosus. ( 18797892 )
2009
21
Drug-induced lupus erythematosus in a patient treated with adalumimab. ( 17434034 )
2007
22
Drug-induced lupus erythematosus. ( 16373256 )
2005
23
Drug-induced lupus erythematosus. ( 15234017 )
2004
24
The utility of antihistone antibody screening in the diagnosis of drug-induced lupus erythematosus. ( 15096389 )
2004
25
Drug-induced lupus erythematosus secondary to nafcillin: the first reported case. ( 14658003 )
2004
26
Drug-induced lupus erythematosus by amiodarone. ( 11926860 )
2002
27
Chlorpromazine induces apoptosis in activated human lymphoblasts: a mechanism supporting the induction of drug-induced lupus erythematosus? ( 11014349 )
2000
28
Drug-induced lupus erythematosus. ( 9642530 )
1998
29
Antibodies to dsDNA in drug induced lupus erythematosus. ( 8006909 )
1994
30
Reticuloendothelial system Fc receptor function in the drug induced lupus erythematosus syndrome. ( 3772920 )
1986
31
Antihistone antibodies and drug-induced lupus erythematosus. ( 3947411 )
1986
32
The diagnostic value of antihistone antibodies in drug-induced lupus erythematosus. ( 3882094 )
1985
33
Reactive hypoglycemia and insulin autoantibodies in drug-induced lupus erythematosus. ( 6349454 )
1983
34
The heterogeneity of serologic findings and predisposing host factors in drug-induced lupus erythematosus. ( 6974553 )
1981
35
Drug-induced lupus erythematosus aggravated by oral zinc therapy. ( 92157 )
1979
36
Lymphocyte alteration by procainamide: relation to drug-induced lupus erythematosus syndrome. ( 90917 )
1979
37
Drug-induced lupus erythematosus. ( 421513 )
1979
38
Procainamide, acetylprocainamide, and drug-induced lupus erythematosus. ( 91813 )
1979
39
Drug-induced lupus erythematosus with in vivo lupus erythematosus cells in pleural fluid. ( 77754 )
1978
40
Drug induced lupus erythematosus--a case report. ( 687309 )
1978
41
Drug-induced lupus erythematosus. ( 68769 )
1977
42
Medical grand rounds--from the Medical College of Virginia. Drug-induced lupus erythematosus. ( 4545011 )
1974
43
Drug-induced lupus erythematosus syndrome. Immuno-pathological, electronmicroscopical and serological studies. ( 4138086 )
1974
44
Studies on drug-induced lupus erythematosus in mice. 3. Renal lesions and splenomegaly in drug-induced lupus erythematosus. ( 4273216 )
1973
45
Studies on drug-induced lupus erythematosus in mice. II. Drug-induced smooth muscle and skeletal muscle antibodies. ( 4587506 )
1973
46
Biologic false-positive FTA-ABS test in drug-induced lupus erythematosus. ( 4574098 )
1973
47
Drug-induced lupus erythematosus. ( 4803375 )
1973
48
Studies on drug induced lupus erythematosus in mice. I. Drug induced antinuclear antibodies (ANA). ( 4557182 )
1972
49
Drug-induced lupus erythematosus. ( 5473639 )
1970

Variations for Drug-Induced Lupus Erythematosus

Expression for Drug-Induced Lupus Erythematosus

Search GEO for disease gene expression data for Drug-Induced Lupus Erythematosus.

Pathways for Drug-Induced Lupus Erythematosus

GO Terms for Drug-Induced Lupus Erythematosus

Sources for Drug-Induced Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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