DIL
MCID: DRG013
MIFTS: 50

Drug-Induced Lupus Erythematosus (DIL)

Categories: Bone diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Drug-Induced Lupus Erythematosus

MalaCards integrated aliases for Drug-Induced Lupus Erythematosus:

Name: Drug-Induced Lupus Erythematosus 12 60 15 74
Dile 12 60
Dil 12

Characteristics:

Orphanet epidemiological data:

60
drug-induced lupus erythematosus
Inheritance: Not applicable; Age of onset: All ages;

Classifications:



External Ids:

Disease Ontology 12 DOID:0040093
ICD10 34 M32.0
ICD10 via Orphanet 35 M32.0
UMLS via Orphanet 75 C0263591
Orphanet 60 ORPHA231111
UMLS 74 C0263591

Summaries for Drug-Induced Lupus Erythematosus

Disease Ontology : 12 A lupus erythematosus caused by chronic use of certain drugs.

MalaCards based summary : Drug-Induced Lupus Erythematosus, also known as dile, is related to lupus erythematosus and hemangioendothelioma. An important gene associated with Drug-Induced Lupus Erythematosus is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways. The drugs Infliximab and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes, and related phenotypes are arthralgia and dyspnea

Wikipedia : 77 Drug-induced lupus erythematosus (DIL or DILE) is an autoimmune disorder (similar to systemic lupus... more...

Related Diseases for Drug-Induced Lupus Erythematosus

Diseases related to Drug-Induced Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 lupus erythematosus 10.8
2 hemangioendothelioma 10.4 KDR PECAM1
3 pulmonary vein stenosis 10.3 KDR PECAM1
4 pemphigus foliaceus 10.3
5 angiokeratoma circumscriptum 10.2 KDR VEGFA
6 kaposiform hemangioendothelioma 10.2 KDR PECAM1 VWF
7 infiltrating angiolipoma 10.2 VEGFA VWF
8 skin hemangioma 10.2 KDR VEGFA
9 epithelioid hemangioendothelioma 10.2 KDR VEGFA
10 hydrocele 10.2 PECAM1 VEGFA
11 angiomatous meningioma 10.2 KDR VEGFA
12 hemangioma 10.2 KDR PECAM1 VEGFA
13 radiation proctitis 10.2 KDR PECAM1 VEGFA
14 capillary hemangioma 10.2 KDR PECAM1 VEGFA
15 leukostasis 10.2 KDR VEGFA
16 limb ischemia 10.1 KDR VEGFA VWF
17 epileptic encephalopathy, childhood-onset 10.1 KDR PROM1 VEGFA
18 lymphangioma 10.1 KDR VEGFA
19 supratentorial cancer 10.1 KDR PROM1 VEGFA
20 diffuse infiltrative lymphocytosis syndrome 10.1
21 cerebrum cancer 10.1 KDR PROM1 VEGFA
22 splenomegaly 10.1
23 ovarian hyperstimulation syndrome 10.1 CDH5 KDR VEGFA
24 syndromic x-linked intellectual disability snyder type 10.1 OLR1 SCARB1
25 gastrointestinal system cancer 10.1 KDR PROM1 VEGFA
26 angiosarcoma 10.0 KDR PECAM1 VEGFA VWF
27 bone squamous cell carcinoma 10.0 ENG KDR
28 melanoma metastasis 10.0 MCAM VEGFA
29 atrial standstill 1 10.0
30 aortic valve disease 1 10.0
31 progressive familial heart block, type ia 10.0
32 cardiac conduction defect 10.0
33 fabry disease 10.0
34 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
35 left bundle branch hemiblock 10.0
36 mitral valve insufficiency 10.0
37 acute cystitis 10.0
38 myocarditis 10.0
39 neuropathy 10.0
40 hypertrophic cardiomyopathy 10.0
41 cerebral aneurysms 10.0
42 arteries, anomalies of 9.9 OLR1 VEGFA VWF
43 cloacogenic carcinoma 9.9 F12 PTPRC
44 thrombocytopenia 9.9
45 lymphoma 9.9
46 cardiac tamponade 9.9
47 hypoglycemia 9.9
48 coats disease 9.9 KDR VEGFA
49 gallbladder adenocarcinoma 9.9 MCAM PROM1
50 juvenile nasopharyngeal angiofibroma 9.8 ENG PECAM1 VEGFA

Graphical network of the top 20 diseases related to Drug-Induced Lupus Erythematosus:



Diseases related to Drug-Induced Lupus Erythematosus

Symptoms & Phenotypes for Drug-Induced Lupus Erythematosus

Human phenotypes related to Drug-Induced Lupus Erythematosus:

60 33 (show all 24)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 60 33 hallmark (90%) Very frequent (99-80%) HP:0002829
2 dyspnea 60 33 hallmark (90%) Very frequent (99-80%) HP:0002094
3 anemia 60 33 hallmark (90%) Very frequent (99-80%) HP:0001903
4 thrombocytopenia 60 33 hallmark (90%) Very frequent (99-80%) HP:0001873
5 myalgia 60 33 hallmark (90%) Very frequent (99-80%) HP:0003326
6 hematuria 60 33 hallmark (90%) Very frequent (99-80%) HP:0000790
7 pericarditis 60 33 hallmark (90%) Very frequent (99-80%) HP:0001701
8 petechiae 60 33 hallmark (90%) Very frequent (99-80%) HP:0000967
9 elevated c-reactive protein level 60 33 hallmark (90%) Very frequent (99-80%) HP:0011227
10 elevated erythrocyte sedimentation rate 60 33 hallmark (90%) Very frequent (99-80%) HP:0003565
11 antinuclear antibody positivity 60 33 hallmark (90%) Very frequent (99-80%) HP:0003493
12 pericardial effusion 60 33 hallmark (90%) Very frequent (99-80%) HP:0001698
13 increased blood urea nitrogen 60 33 hallmark (90%) Very frequent (99-80%) HP:0003138
14 prolonged qtc interval 60 33 hallmark (90%) Very frequent (99-80%) HP:0005184
15 decreased serum complement c3 60 33 hallmark (90%) Very frequent (99-80%) HP:0005421
16 malar rash 60 33 hallmark (90%) Very frequent (99-80%) HP:0025300
17 lupus anticoagulant 60 33 hallmark (90%) Very frequent (99-80%) HP:0025343
18 decreased serum complement c4 60 33 hallmark (90%) Very frequent (99-80%) HP:0045042
19 elevated serum creatine kinase 33 hallmark (90%) HP:0003236
20 fever 60 33 frequent (33%) Frequent (79-30%) HP:0001945
21 elevated serum creatine phosphokinase 60 Very frequent (99-80%)
22 autoimmune antibody positivity 60 Very frequent (99-80%)
23 constitutional symptom 60 Occasional (29-5%)
24 serositis 60 Frequent (79-30%)

MGI Mouse Phenotypes related to Drug-Induced Lupus Erythematosus:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.17 CDH5 ENG KDR KLKB1 MCAM OLR1
2 homeostasis/metabolism MP:0005376 10.15 CDH5 ENG F12 KDR KLKB1 MCAM
3 hematopoietic system MP:0005397 10.06 CDH5 ENG KDR MCAM PECAM1 PTPRC
4 immune system MP:0005387 9.97 CDH5 KDR MCAM OLR1 PECAM1 PTPRC
5 liver/biliary system MP:0005370 9.73 CDH5 KDR PECAM1 PTPRC SCARB1 VEGFA
6 muscle MP:0005369 9.55 ENG KDR OLR1 PECAM1 VEGFA
7 no phenotypic analysis MP:0003012 9.43 KDR MCAM PROM1 PTPRC VEGFA VWF
8 normal MP:0002873 9.23 CDH5 ENG F12 KDR OLR1 PROM1

Drugs & Therapeutics for Drug-Induced Lupus Erythematosus

Drugs for Drug-Induced Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved 170277-31-3
2 Dermatologic Agents
3 Antirheumatic Agents
4 Gastrointestinal Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 a Single-center Registered Clinical Research of Chinese Patients With Moderate to Severe Crohn's Disease Unknown status NCT02088944 Infliximab
2 Autoimmune Paradoxical Reactions in IBD Longitudinal Cohort Completed NCT02503514

Search NIH Clinical Center for Drug-Induced Lupus Erythematosus

Genetic Tests for Drug-Induced Lupus Erythematosus

Anatomical Context for Drug-Induced Lupus Erythematosus

MalaCards organs/tissues related to Drug-Induced Lupus Erythematosus:

42
Skin, Bone, Testes, Smooth Muscle, Skeletal Muscle

Publications for Drug-Induced Lupus Erythematosus

Articles related to Drug-Induced Lupus Erythematosus:

(show all 50)
# Title Authors Year
1
Response to: 'Drug-induced lupus erythematosus following immunotherapy with anti-programmed death-(ligand) 1' by Michot <i>et al</i>. ( 29934372 )
2018
2
Drug-induced lupus erythematosus secondary to pirfenidone. ( 29266198 )
2018
3
Drug-induced lupus erythematosus: an update on drugs and mechanisms. ( 29870500 )
2018
4
Drug-induced lupus erythematosus following immunotherapy with anti-programmed death-(ligand) 1. ( 29858173 )
2018
5
A case of lupus-like syndrome in a patient receiving adalimumab and a brief review of the literature on drug-induced lupus erythematosus. ( 28191663 )
2017
6
Drug-induced lupus erythematosus mimicking lymphoma on (18)F-FDG-PET/CT. ( 28420045 )
2017
7
Drug-Induced Lupus Erythematosus Associated with Antiretroviral Therapy in a Patient with Human Immunodeficiency Virus: A Case Report. ( 29147636 )
2017
8
A case of drug-induced lupus erythematosus secondary to trimethoprim/sulfamethoxazole presenting with pleural effusions and pericardial tamponade. ( 27357280 )
2016
9
Drug Induced Lupus Erythematosus Due to Capecitabine and Bevacizumab Treatment Presenting with Prolonged Thrombocytopenia. ( 26710505 )
2015
10
Drug-induced lupus erythematosus associated with donepezil: a case report. ( 26420637 )
2015
11
Drug-induced lupus erythematosus. ( 24819757 )
2014
12
Drug-Induced Lupus Erythematosus Presenting With Cardiac Tamponade: A Case Report and Literature Review. ( 24373757 )
2013
13
Drug-Induced Lupus Erythematosus. ( 24388458 )
2013
14
Drug-induced lupus erythematosus with emphasis on skin manifestations and the role of anti-TNFI+ agents. ( 22937775 )
2012
15
Drug-Induced Lupus Erythematosus. ( 23164669 )
2012
16
Drug-induced lupus erythematosus: incidence, management and prevention. ( 21513360 )
2011
17
Episcleritis Related to Drug-Induced Lupus Erythematosus following Infliximab Therapy: A Case Report. ( 21547267 )
2011
18
Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men. ( 20376687 )
2010
19
Drug reaction with herbal supplement: a possible case of drug induced lupus erythematosus. ( 25606196 )
2010
20
Drug-induced lupus erythematosus. ( 18797892 )
2009
21
Drug-induced lupus erythematosus in a patient treated with adalumimab. ( 17434034 )
2007
22
Drug-induced lupus erythematosus. ( 16373256 )
2005
23
Drug-induced lupus erythematosus. ( 15234017 )
2004
24
The utility of antihistone antibody screening in the diagnosis of drug-induced lupus erythematosus. ( 15096389 )
2004
25
Drug-induced lupus erythematosus secondary to nafcillin: the first reported case. ( 14658003 )
2004
26
Drug-induced lupus erythematosus by amiodarone. ( 11926860 )
2002
27
Chlorpromazine induces apoptosis in activated human lymphoblasts: a mechanism supporting the induction of drug-induced lupus erythematosus? ( 11014349 )
2000
28
Drug-induced lupus erythematosus. ( 9642530 )
1998
29
Antibodies to dsDNA in drug induced lupus erythematosus. ( 8006909 )
1994
30
Reticuloendothelial system Fc receptor function in the drug induced lupus erythematosus syndrome. ( 3772920 )
1986
31
Antihistone antibodies and drug-induced lupus erythematosus. ( 3947411 )
1986
32
The diagnostic value of antihistone antibodies in drug-induced lupus erythematosus. ( 3882094 )
1985
33
Reactive hypoglycemia and insulin autoantibodies in drug-induced lupus erythematosus. ( 6349454 )
1983
34
The heterogeneity of serologic findings and predisposing host factors in drug-induced lupus erythematosus. ( 6974553 )
1981
35
Drug-induced lupus erythematosus aggravated by oral zinc therapy. ( 92157 )
1979
36
Lymphocyte alteration by procainamide: relation to drug-induced lupus erythematosus syndrome. ( 90917 )
1979
37
Drug-induced lupus erythematosus. ( 421513 )
1979
38
Procainamide, acetylprocainamide, and drug-induced lupus erythematosus. ( 91813 )
1979
39
Drug-induced lupus erythematosus with in vivo lupus erythematosus cells in pleural fluid. ( 77754 )
1978
40
Drug induced lupus erythematosus--a case report. ( 687309 )
1978
41
Drug-induced lupus erythematosus. ( 68769 )
1977
42
Medical grand rounds--from the Medical College of Virginia. Drug-induced lupus erythematosus. ( 4545011 )
1974
43
Drug-induced lupus erythematosus syndrome. Immuno-pathological, electronmicroscopical and serological studies. ( 4138086 )
1974
44
Studies on drug-induced lupus erythematosus in mice. 3. Renal lesions and splenomegaly in drug-induced lupus erythematosus. ( 4273216 )
1973
45
Studies on drug-induced lupus erythematosus in mice. II. Drug-induced smooth muscle and skeletal muscle antibodies. ( 4587506 )
1973
46
Biologic false-positive FTA-ABS test in drug-induced lupus erythematosus. ( 4574098 )
1973
47
Drug-induced lupus erythematosus. ( 4803375 )
1973
48
Studies on drug induced lupus erythematosus in mice. I. Drug induced antinuclear antibodies (ANA). ( 4557182 )
1972
49
Drug-induced lupus erythematosus. ( 5473639 )
1970
50
Atresia of the intrahepatic dile ducts. ( 14891320 )
1951

Variations for Drug-Induced Lupus Erythematosus

Expression for Drug-Induced Lupus Erythematosus

Search GEO for disease gene expression data for Drug-Induced Lupus Erythematosus.

Pathways for Drug-Induced Lupus Erythematosus

Pathways related to Drug-Induced Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 F12 KLKB1 OLR1 PECAM1 VEGFA VWF
2
Show member pathways
12.29 CDH5 KDR PECAM1 VEGFA
3
Show member pathways
11.9 F12 KLKB1 VWF
4
Show member pathways
11.85 KDR PECAM1 VWF
5 11.81 CDH5 PECAM1 PTPRC
6 11.78 F12 KLKB1 VWF
7 11.73 KDR PROM1 VEGFA
8
Show member pathways
11.6 CDH5 KDR VEGFA
9 11.6 CDH5 KDR PECAM1 VEGFA
10
Show member pathways
11.4 CDH5 KDR VEGFA
11 11.07 KDR VEGFA
12 10.97 CDH5 ENG KDR PECAM1 VWF
13 10.95 F12 KDR KLKB1 VEGFA
14 10.89 KDR VEGFA

GO Terms for Drug-Induced Lupus Erythematosus

Cellular components related to Drug-Induced Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.95 ENG F12 KLKB1 MCAM PECAM1 PROM1
2 extracellular exosome GO:0070062 9.86 ARL8A F12 KLKB1 PECAM1 PROM1 PTPRC
3 membrane raft GO:0045121 9.67 KDR OLR1 PECAM1 PTPRC
4 external side of plasma membrane GO:0009897 9.55 CDH5 ENG MCAM PECAM1 PTPRC
5 cell periphery GO:0071944 9.5 CDH5 PECAM1 PTPRC
6 microvillus membrane GO:0031528 9.43 PROM1 SCARB1
7 cell surface GO:0009986 9.43 CDH5 ENG PROM1 PTPRC SCARB1 VEGFA
8 plasma membrane GO:0005886 9.4 ARL8A CDH5 ENG F12 KDR KLKB1
9 extracellular region GO:0005576 10 F12 KDR KLKB1 MCAM OLR1 VEGFA

Biological processes related to Drug-Induced Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.91 ARL8A OLR1 PECAM1 PTPRC
2 blood coagulation GO:0007596 9.81 F12 KLKB1 VWF
3 positive regulation of protein phosphorylation GO:0001934 9.8 ENG KDR VEGFA
4 platelet degranulation GO:0002576 9.73 PECAM1 VEGFA VWF
5 vasculogenesis GO:0001570 9.65 ENG KDR VEGFA
6 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.64 KDR VEGFA
7 sprouting angiogenesis GO:0002040 9.63 ENG VEGFA
8 hemostasis GO:0007599 9.63 F12 KLKB1 VWF
9 cell adhesion GO:0007155 9.63 CDH5 ENG MCAM OLR1 PECAM1 VWF
10 branching involved in blood vessel morphogenesis GO:0001569 9.62 ENG VEGFA
11 positive regulation of angiogenesis GO:0045766 9.62 CDH5 ENG KDR VEGFA
12 leukocyte cell-cell adhesion GO:0007159 9.61 PECAM1 PTPRC
13 positive regulation of focal adhesion assembly GO:0051894 9.6 KDR VEGFA
14 artery morphogenesis GO:0048844 9.59 ENG VEGFA
15 calcium-mediated signaling using intracellular calcium source GO:0035584 9.58 KDR PTPRC
16 fibrinolysis GO:0042730 9.58 F12 KLKB1
17 positive regulation of endothelial cell migration GO:0010595 9.58 KDR SCARB1 VEGFA
18 cell migration involved in sprouting angiogenesis GO:0002042 9.57 KDR VEGFA
19 vascular endothelial growth factor signaling pathway GO:0038084 9.55 KDR VEGFA
20 zymogen activation GO:0031638 9.54 F12 KLKB1
21 positive regulation of positive chemotaxis GO:0050927 9.52 KDR VEGFA
22 negative regulation of protein autophosphorylation GO:0031953 9.51 ENG PTPRC
23 regulation of phagocytosis GO:0050764 9.49 PTPRC SCARB1
24 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.43 KDR VEGFA
25 positive regulation of fibrinolysis GO:0051919 9.37 F12 KLKB1
26 angiogenesis GO:0001525 9.35 ENG KDR MCAM PECAM1 VEGFA
27 Factor XII activation GO:0002542 9.26 F12 KLKB1
28 blood coagulation, intrinsic pathway GO:0007597 8.8 F12 KLKB1 VWF

Molecular functions related to Drug-Induced Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.77 ARL8A CDH5 ENG F12 KDR KLKB1
2 protein homodimerization activity GO:0042803 9.17 CDH5 ENG PECAM1 PTPRC SCARB1 VEGFA

Sources for Drug-Induced Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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