DIL
MCID: DRG013
MIFTS: 49

Drug-Induced Lupus Erythematosus (DIL)

Categories: Bone diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Drug-Induced Lupus Erythematosus

MalaCards integrated aliases for Drug-Induced Lupus Erythematosus:

Name: Drug-Induced Lupus Erythematosus 12 58 15 71
Dile 12 58
Dil 12

Characteristics:

Orphanet epidemiological data:

58
drug-induced lupus erythematosus
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare systemic and rhumatological diseases
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:0040093
NCIt 50 C114354
SNOMED-CT 67 80258006
ICD10 32 M32.0
ICD10 via Orphanet 33 M32.0
UMLS via Orphanet 72 C0263591
Orphanet 58 ORPHA231111
UMLS 71 C0263591

Summaries for Drug-Induced Lupus Erythematosus

Disease Ontology : 12 A lupus erythematosus caused by chronic use of certain drugs.

MalaCards based summary : Drug-Induced Lupus Erythematosus, also known as dile, is related to exanthem and pericarditis. An important gene associated with Drug-Induced Lupus Erythematosus is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. Affiliated tissues include skin, bone and smooth muscle, and related phenotypes are anemia and thrombocytopenia

Wikipedia : 74 Drug-induced lupus erythematosus is an autoimmune disorder caused by chronic use of certain drugs. These... more...

Related Diseases for Drug-Induced Lupus Erythematosus

Diseases related to Drug-Induced Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 835)
# Related Disease Score Top Affiliating Genes
1 exanthem 30.5 TNF IL6 IL1B IL10 H2AC18 CXCL8
2 pericarditis 30.5 TNF IL6 IL1B CXCL8
3 erythema multiforme 30.5 TNF IL6 IL4 CXCL8
4 pemphigus 30.5 TNF IL6 IL4 IL10
5 bacteriuria 30.3 IL6 H2AC18 CXCL8 ALB
6 cutaneous lupus erythematosus 30.3 TNF IL6 IL1B IL17A IL10
7 central nervous system disease 30.2 TNF IL6 IL1B IL17A H2AC18 ALB
8 arthritis 29.8 TNF IL6 IL4 IL1B IL17A IL10
9 vascular disease 29.8 TNF PECAM1 IL6 IL10 GAPDH CD4
10 systemic lupus erythematosus 29.6 TNF PTPRC IL6 IL4 IL1B IL17A
11 thrombocytopenia 29.5 TNF PECAM1 IL6 IL4 IL1B IL17A
12 inflammatory bowel disease 29.4 TNF PTPRC PECAM1 IL6 IL4 IL1B
13 immune deficiency disease 29.3 TNF PTPRC IL6 IL4 IL1B IL17A
14 nervous system disease 29.2 TNF IL6 IL4 IL1B IL17A IL10
15 external pathological resorption 10.5 TNF IL6
16 scorpion envenomation 10.5 TNF IL6
17 subacute glomerulonephritis 10.5 ALB ACTB
18 punctate inner choroidopathy 10.5 TNF IL10
19 staphylococcal toxic shock syndrome 10.5 TNF IL1B
20 prosthetic joint infection 10.5 IL6 IL1B
21 physiological polycythemia 10.5 TNF IL6 IL1B
22 periodontitis, chronic 10.5 IL6 IL1B
23 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 TNF IL6
24 ulcer of lower limbs 10.4 TNF IL6 IL1B
25 skin epithelioid hemangioma 10.4 PECAM1 CD34
26 multifocal choroiditis 10.4 TNF IL10
27 stachybotrys chartarum 10.4 TNF IL6 IL1B
28 vulvar vestibulitis syndrome 10.4 TNF IL1B
29 gingival recession 10.4 TNF IL6 IL1B
30 lupus erythematosus 10.4
31 cardiogenic shock 10.4 TNF IL6
32 spotted fever rickettsiosis 10.4 TNF IL10
33 laryngitis 10.4 TNF IL6 IL1B
34 lice infestation 10.4 H2AC18 ALB ACTB
35 asphyxia neonatorum 10.4 IL6 IL1B ALB
36 aortic malignant tumor 10.4 PECAM1 CD34
37 prostate angiosarcoma 10.4 PECAM1 CD34
38 kashin-beck disease 10.4 TNF IL1B
39 central nervous system angiosarcoma 10.4 PECAM1 CD34
40 intravascular angioleiomyoma 10.4 PECAM1 CD34
41 glossitis 10.4 TNF IL6 IL1B
42 erysipelas 10.4 TNF IL6 IL1B
43 coronary aneurysm 10.4 TNF IL6 ALB
44 tendinitis 10.4 TNF IL6 IL1B
45 heart aneurysm 10.4 TNF IL6 ALB
46 euthyroid sick syndrome 10.4 IL6 IL1B ALB
47 subacute thyroiditis 10.4 TNF IL6 IL1B
48 chronic recurrent multifocal osteomyelitis 10.4 TNF IL6 IL1B
49 central nervous system hemangioma 10.4 PECAM1 CD34
50 brain injury 10.4 IL6 IL1B ALB

Graphical network of the top 20 diseases related to Drug-Induced Lupus Erythematosus:



Diseases related to Drug-Induced Lupus Erythematosus

Symptoms & Phenotypes for Drug-Induced Lupus Erythematosus

Human phenotypes related to Drug-Induced Lupus Erythematosus:

58 31 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 anemia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001903
2 thrombocytopenia 58 31 hallmark (90%) Very frequent (99-80%) HP:0001873
3 elevated serum creatine kinase 58 31 hallmark (90%) Very frequent (99-80%) HP:0003236
4 hematuria 58 31 hallmark (90%) Very frequent (99-80%) HP:0000790
5 dyspnea 58 31 hallmark (90%) Very frequent (99-80%) HP:0002094
6 arthralgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002829
7 myalgia 58 31 hallmark (90%) Very frequent (99-80%) HP:0003326
8 pericarditis 58 31 hallmark (90%) Very frequent (99-80%) HP:0001701
9 petechiae 58 31 hallmark (90%) Very frequent (99-80%) HP:0000967
10 elevated c-reactive protein level 58 31 hallmark (90%) Very frequent (99-80%) HP:0011227
11 elevated erythrocyte sedimentation rate 58 31 hallmark (90%) Very frequent (99-80%) HP:0003565
12 pericardial effusion 58 31 hallmark (90%) Very frequent (99-80%) HP:0001698
13 decreased serum complement c3 58 31 hallmark (90%) Very frequent (99-80%) HP:0005421
14 antinuclear antibody positivity 58 31 hallmark (90%) Very frequent (99-80%) HP:0003493
15 malar rash 58 31 hallmark (90%) Very frequent (99-80%) HP:0025300
16 increased blood urea nitrogen 58 31 hallmark (90%) Very frequent (99-80%) HP:0003138
17 prolonged qtc interval 58 31 hallmark (90%) Very frequent (99-80%) HP:0005184
18 lupus anticoagulant 58 31 hallmark (90%) Very frequent (99-80%) HP:0025343
19 decreased serum complement c4 58 31 hallmark (90%) Very frequent (99-80%) HP:0045042
20 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
21 autoimmune antibody positivity 58 Very frequent (99-80%)
22 constitutional symptom 58 Occasional (29-5%)
23 serositis 58 Frequent (79-30%)

GenomeRNAi Phenotypes related to Drug-Induced Lupus Erythematosus according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 ACTB ALB CD34 CXCL8 GAPDH IL17A

MGI Mouse Phenotypes related to Drug-Induced Lupus Erythematosus:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.41 ACTB ALB AQP3 AVPR2 CD34 CD4
2 growth/size/body region MP:0005378 10.36 ACTB AQP3 AVPR2 CD4 GAPDH IL10
3 hematopoietic system MP:0005397 10.34 ACTB AVPR2 CD34 CD4 GAPDH IL10
4 immune system MP:0005387 10.33 ACTB ALB AQP3 CD34 CD4 IL10
5 cardiovascular system MP:0005385 10.31 ACTB ALB AQP3 GAPDH IL10 IL1B
6 mortality/aging MP:0010768 10.27 ACTB ALB AQP3 AVPR2 CD4 GAPDH
7 digestive/alimentary MP:0005381 10.26 ALB AQP3 CD4 IL10 IL17A IL4
8 integument MP:0010771 10.21 AVPR2 CD34 CD4 IL10 IL17A IL1B
9 liver/biliary system MP:0005370 10.1 ACTB ALB GAPDH IL10 IL4 IL6
10 muscle MP:0005369 9.92 ACTB ALB IL10 IL6 KDR LBX1
11 neoplasm MP:0002006 9.91 ACTB ALB CD34 IL10 IL1B IL6
12 no phenotypic analysis MP:0003012 9.76 ACTB CD4 IL10 IL17A IL4 KDR
13 renal/urinary system MP:0005367 9.61 ALB AQP3 AVPR2 GAPDH IL17A IL4
14 respiratory system MP:0005388 9.32 AQP3 IL10 IL17A IL4 IL6 KDR

Drugs & Therapeutics for Drug-Induced Lupus Erythematosus

Search Clinical Trials , NIH Clinical Center for Drug-Induced Lupus Erythematosus

Genetic Tests for Drug-Induced Lupus Erythematosus

Anatomical Context for Drug-Induced Lupus Erythematosus

MalaCards organs/tissues related to Drug-Induced Lupus Erythematosus:

40
Skin, Bone, Smooth Muscle, Skeletal Muscle, Cervix

Publications for Drug-Induced Lupus Erythematosus

Articles related to Drug-Induced Lupus Erythematosus:

(show top 50) (show all 165)
# Title Authors PMID Year
1
Tofacitinib-induced subacute cutaneous lupus erythematosus in a patient with rheumatoid arthritis. 61
33492185 2021
2
Antithyroid Drug-Induced Lupus Erythematosus and Immunoglobulin A Deficiency. 61
33349625 2020
3
Antinuclear antibody (ANA) monitoring in drug-induced lupus erythematosus (DILE). 61
33367860 2020
4
Complication of Mycobacterium tuberculosis treatment: Isoniazid-induced pneumonitis. 61
32987178 2020
5
The Effect of Biological Agents on Antinuclear Antibody Status in Patients with Psoriasis: A Single-Center Study. 61
33344337 2020
6
Association Between Drug Use and Subsequent Diagnosis of Lupus Erythematosus. 61
32876672 2020
7
Discoid drug-induced lupus erythematosus induced by antitumor necrosis factor agents is a very rare subtype of cutaneous lupus: Three cases and literature review. 61
32239589 2020
8
Discoid Lupus Erythematosus Lesions Associated with Systemic Fluorouracil Agents: A Case Report and Review. 61
32467803 2020
9
Acute interstitial nephritis and drug-induced systemic lupus erythematosus due to chlorthalidone and amiodarone: A case report. 61
32166031 2020
10
Response to: 'Drug-induced lupus erythematosus following immunotherapy with anti-programmed death-(ligand) 1' by Michot et al and 'Checkpoint inhibitor-associated immune arthritis' by Arnaud et al. 61
29934372 2019
11
Drug-induced lupus erythematosus following immunotherapy with anti-programmed death-(ligand) 1. 61
29858173 2019
12
Carbamazepine-induced systemic lupus erythematosus: A case-based review. 61
30388076 2019
13
When Chest Pain Reveals More: A Case of Hydrochlorothiazide-Induced Systemic Lupus Erythematosus. 61
30613100 2019
14
Lamotrigine-induced Systemic Lupus Erythematosus: A Diagnostic Dilemma. 61
30505789 2018
15
Hydralazine-associated vasculitis: Overlapping features of drug-induced lupus and vasculitis. 61
29519741 2018
16
Drug-induced lupus erythematosus: an update on drugs and mechanisms. 61
29870500 2018
17
Drug-induced lupus erythematosus secondary to pirfenidone. 61
29266198 2018
18
Drug-induced Subacute Cutaneous Lupus Erythematosus Caused by a Topical Beta Blocker - Timolol. 61
29782299 2018
19
[Secukinumab-induced subacute-cutaneous lupus erythematosus]. 61
29075868 2018
20
Drug-Induced Lupus Erythematosus Associated with Antiretroviral Therapy in a Patient with Human Immunodeficiency Virus: A Case Report. 61
29147636 2017
21
Drug-Induced by Systemic Lupus Erythematosus Presenting as Recurrent Pericardial Effusion After Mitral Valve Repair. 61
29202555 2017
22
Drug-induced lupus erythematosus mimicking lymphoma on 18F-FDG-PET/CT. 61
28420045 2017
23
A case of lupus-like syndrome in a patient receiving adalimumab and a brief review of the literature on drug-induced lupus erythematosus. 61
28191663 2017
24
[Relationship between the environmental factors and the CPUE (catch per unit effort) of Pseudocarcharias kamoharai in tropical Atlantic Ocean based on the GAM-Tweedie model]. 61
29745167 2017
25
A case of drug-induced lupus erythematosus secondary to trimethoprim/sulfamethoxazole presenting with pleural effusions and pericardial tamponade. 61
27357280 2017
26
Treatment of antiviral-resistant recurrent erythema multiforme with dapsone. 61
27860166 2017
27
Drug-induced systemic lupus erythematosus in a child after 3 years of treatment with carbamazepine. 61
26424435 2017
28
Hydralazine Induced Lupus Syndrome Presenting with Recurrent Pericardial Effusion and a Negative Antinuclear Antibody. 61
28194293 2017
29
ANA-Negative Hydralazine-Induced Pericardial Effusion. 61
29391867 2017
30
Isoniazid Induced Lupus Presenting as Oral Mucosal Ulcers with Pancytopenia. 61
27891378 2016
31
Coexistence of Fetal Cardiac Malformation and Maternal Drug-Induced Lupus: Is Lamotrigine Safe? 61
26418583 2016
32
A simple estimation of ideal profile of essential amino acids and metabolizable energy for growing Japanese quail. 61
26671312 2016
33
A proposed mechanism for the adverse effects of acebutolol: CES2 and CYP2C19-mediated metabolism and antinuclear antibody production. 61
26408002 2015
34
Drug-induced lupus erythematosus associated with donepezil: a case report. 61
26420637 2015
35
Spondyloarthropathy in inflammatory bowel disease patients on TNF inhibitors. 61
26337851 2015
36
Systemic lupus erythematosus in Crohn's disease: drug-induced or idiopathic? 61
26126856 2015
37
Drug Induced Lupus Erythematosus Due to Capecitabine and Bevacizumab Treatment Presenting with Prolonged Thrombocytopenia. 61
26710505 2015
38
Adalimumab-Induced Cutaneous Lupus Erythematosus in a 16-Year-Old Girl with Juvenile Idiopathic Arthritis. 61
25845414 2015
39
Isoniazid in autoimmunity: a trigger for multiple sclerosis? 61
25342979 2014
40
Drug-induced lupus erythematosus. 61
24819757 2014
41
Hydralazine-induced toxic epidermal necrolysis in a patient on continuous ambulatory peritoneal dialysis. 61
24588409 2014
42
Autoantibodies in psoriatic patients treated with anti-TNF-α therapy. 61
24797746 2014
43
Drug-induced lupus: Including anti-tumour necrosis factor and interferon induced. 61
24557776 2014
44
Drug-induced lupus erythematosus presenting with cardiac tamponade: a case report and literature review. 61
24373757 2014
45
Drug-induced lupus erythematosus. 61
23164669 2014
46
Drug-induced subacute cutaneous lupus erythematosus associated with nab-paclitaxel therapy. 61
24155645 2013
47
Vasotocin analogues with selective natriuretic, kaliuretic and antidiuretic effects in rats. 61
23835093 2013
48
Tumor necrosis factor-α antagonists: Side effects and their management. 61
23974693 2013
49
[Development of lupus erythematosus during infliximab therapy]. 61
23567877 2013
50
An unexpected side-effect of a commonly used drug. 61
24282922 2013

Variations for Drug-Induced Lupus Erythematosus

Expression for Drug-Induced Lupus Erythematosus

Search GEO for disease gene expression data for Drug-Induced Lupus Erythematosus.

Pathways for Drug-Induced Lupus Erythematosus

Pathways related to Drug-Induced Lupus Erythematosus according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.07 TNF PTPRC PECAM1 IL6 IL4 IL1B
2
Show member pathways
13.86 TNF KDR IL6 IL4 IL1B IL17A
3
Show member pathways
13.71 TNF KDR IL6 IL4 IL1B IL17A
4
Show member pathways
13.58 TNF KDR IL6 IL4 IL1B IL17A
5
Show member pathways
13.48 TNF KDR IL6 IL4 IL1B IL17A
6
Show member pathways
13.4 TNF IL6 IL4 IL1B IL17A IL10
7
Show member pathways
13.37 TNF PTPRC KDR IL6 IL4 IL1B
8
Show member pathways
12.91 TNF IL6 IL4 IL1B IL17A IL10
9
Show member pathways
12.84 TNF PTPRC IL6 IL1B GAPDH CXCL8
10
Show member pathways
12.69 TNF PTPRC IL6 IL4 IL1B IL17A
11
Show member pathways
12.68 TNF IL6 IL1B IL17A IL10 CD4
12
Show member pathways
12.68 TNF IL6 IL4 IL1B IL17A IL10
13
Show member pathways
12.67 TNF PTPRC IL4 IL10 CD4
14 12.64 TNF PTPRC PECAM1 IL4 IL1B IL17A
15
Show member pathways
12.43 TNF IL6 IL4 IL1B IL17A CXCL8
16
Show member pathways
12.41 TNF IL6 IL4 IL1B ALB
17
Show member pathways
12.36 TNF IL6 IL10 CXCL8
18
Show member pathways
12.35 TNF KDR IL6 IL4 IL1B IL17A
19
Show member pathways
12.29 TNF IL4 IL1B IL10
20
Show member pathways
12.28 TNF IL6 IL4 IL1B CXCL8
21 12.27 TNF IL6 IL1B CXCL8
22 12.27 TNF IL6 IL1B IL10
23
Show member pathways
12.25 TNF IL6 IL1B IL10
24 12.23 TNF TLX3 IL6 IL1B IL10 GAPDH
25 12.19 TNF PECAM1 KDR IL1B ACTB
26 12.17 PTPRC PECAM1 CD4 CD34
27 12.12 TNF IL6 IL4 IL1B CXCL8
28 12.11 TNF IL6 IL1B IL10 CXCL8 CD4
29 12.03 TNF IL6 IL1B IL10 CXCL8
30 12.03 TNF IL6 IL4 IL1B CD4 CD34
31 12.01 TNF PTPRC IL6 IL4 IL10 CD4
32 11.98 TNF IL6 IL1B CXCL8
33 11.98 TNF IL6 IL1B IL17A CXCL8
34 11.97 TNF IL6 IL4 IL1B IL17A IL10
35
Show member pathways
11.96 IL6 IL4 IL1B IL17A CD4
36 11.86 TNF IL6 IL1B IL10 CXCL8
37
Show member pathways
11.81 TNF IL6 IL1B IL17A IL10 CD4
38 11.79 TNF IL6 IL4 IL10
39
Show member pathways
11.78 TNF IL4 CXCL8
40
Show member pathways
11.77 TNF IL6 IL1B CXCL8
41 11.77 TNF IL6 IL4 IL1B CXCL8
42 11.71 TNF IL6 IL1B CXCL8
43 11.57 TNF PTPRC IL6 IL1B IL10 CD4
44 11.56 TNF IL1B ACTB
45 11.54 IL4 IL10 CD4
46 11.53 TNF IL6 IL1B
47 11.5 TNF IL6 IL1B IL10
48 11.5 TNF PECAM1 IL6 IL1B IL10 CXCL8
49 11.47 TNF IL6 IL1B IL10
50 11.42 TNF IL6 IL4 IL1B IL10 CXCL8

GO Terms for Drug-Induced Lupus Erythematosus

Cellular components related to Drug-Induced Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.85 TNF KDR IL6 IL4 IL1B IL17A
2 external side of plasma membrane GO:0009897 9.65 TNF PTPRC IL17A CD4 CD34
3 membrane raft GO:0045121 9.35 TNF PTPRC PECAM1 KDR CD4
4 extracellular space GO:0005615 9.32 TNF PECAM1 IL6 IL4 IL1B IL17A

Biological processes related to Drug-Induced Lupus Erythematosus according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.32 PECAM1 IL6 IL4 IL1B IL10 CXCL8
2 positive regulation of transcription, DNA-templated GO:0045893 10.16 TNF IL6 IL4 IL1B IL10 CD4
3 inflammatory response GO:0006954 10.08 TNF IL6 IL1B IL17A CXCL8
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 10 TNF PTPRC KDR CD4
5 negative regulation of cell proliferation GO:0008285 10 LBX1 IL6 IL1B IL10 CXCL8 AVPR2
6 positive regulation of angiogenesis GO:0045766 9.94 KDR IL1B CXCL8 CD34
7 negative regulation of tumor necrosis factor production GO:0032720 9.89 IL4 IL10 CD34
8 regulation of insulin secretion GO:0050796 9.89 TNF IL6 IL1B
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.88 TNF IL6 IL4
10 positive regulation of MAPK cascade GO:0043410 9.88 PTPRC KDR IL6 CD4
11 positive regulation of protein phosphorylation GO:0001934 9.88 TNF PECAM1 KDR IL1B CD4
12 response to glucocorticoid GO:0051384 9.87 TNF IL6 IL10
13 positive regulation of protein kinase activity GO:0045860 9.87 TNF PTPRC CD4
14 positive regulation of gene expression GO:0010628 9.87 TNF IL6 IL4 IL1B CXCL8 CD34
15 positive regulation of interleukin-8 production GO:0032757 9.86 TNF IL6 IL1B
16 positive regulation of DNA-binding transcription factor activity GO:0051091 9.86 TNF IL6 IL1B IL10
17 positive regulation of interleukin-1 beta production GO:0032731 9.85 TNF IL6 IL17A
18 positive regulation of cytokine production GO:0001819 9.85 TNF IL10 GAPDH
19 T cell activation GO:0042110 9.82 PTPRC IL4 CD4
20 protein kinase B signaling GO:0043491 9.81 TNF KDR IL1B
21 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.81 PTPRC PECAM1 IL6 CD4
22 positive regulation of interleukin-10 production GO:0032733 9.8 IL6 IL4 CD34
23 negative regulation of endothelial cell apoptotic process GO:2000352 9.8 KDR IL4 IL10
24 positive regulation of interleukin-6 production GO:0032755 9.8 TNF IL6 IL1B IL17A
25 cellular response to lipopolysaccharide GO:0071222 9.8 TNF IL6 IL1B IL10 CXCL8
26 positive regulation of JAK-STAT cascade GO:0046427 9.77 TNF IL6 IL10
27 immune response GO:0006955 9.76 TNF IL6 IL4 IL1B IL17A IL10
28 positive regulation of interleukin-2 production GO:0032743 9.75 PTPRC IL1B CD4
29 maintenance of permeability of blood-brain barrier GO:0035633 9.74 PECAM1 IL6 ACTB
30 negative regulation of neurogenesis GO:0050768 9.72 TNF IL6 IL1B
31 regulation of establishment of endothelial barrier GO:1903140 9.71 TNF IL1B
32 positive regulation of isotype switching to IgG isotypes GO:0048304 9.71 PTPRC IL4
33 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.71 TNF IL6 IL17A
34 negative regulation of lipid storage GO:0010888 9.7 TNF IL6
35 endothelial cell apoptotic process GO:0072577 9.7 TNF IL10
36 vascular wound healing GO:0061042 9.69 KDR CD34
37 positive regulation of mononuclear cell migration GO:0071677 9.67 TNF IL4
38 positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 9.67 TNF PTPRC
39 negative regulation of cytokine production involved in immune response GO:0002719 9.67 TNF IL10
40 type 2 immune response GO:0042092 9.66 IL4 IL10
41 positive regulation of fever generation GO:0031622 9.65 TNF IL1B
42 endothelium development GO:0003158 9.65 KDR CD34
43 sequestering of triglyceride GO:0030730 9.64 TNF IL1B
44 positive regulation of glial cell proliferation GO:0060252 9.63 TNF IL6 IL1B
45 glomerular endothelium development GO:0072011 9.62 PECAM1 CD34
46 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 TNF IL1B
47 regulation of isotype switching GO:0045191 9.61 IL4 IL10
48 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 TNF IL1B IL10
49 positive regulation of T cell mediated immunity GO:0002711 9.6 PTPRC IL1B
50 positive regulation of neuroinflammatory response GO:0150078 9.54 TNF IL6 IL1B

Molecular functions related to Drug-Induced Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.96 TNF TLX3 PTPRC PECAM1 LBX1 KDR
2 cytokine activity GO:0005125 9.17 TNF IL6 IL4 IL1B IL17A IL10

Sources for Drug-Induced Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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